Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow in Cardiology, Medicine, Duke University 1999 - 2003
  • Medical Resident, Medicine, University of Cincinnati 1996 - 1999
  • M.D., University of Cincinnati 1996
• 

  Previous Appointments & Affiliations

  • Associate Professor of Medicine, Medicine, Cardiology, Medicine 2016 - 2020
  • Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2011 - 2016
  • Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2004 - 2011
  • Associate in the Department of Medicine, Medicine, Cardiology, Medicine 2003 - 2004
  • Instructor, Temporary in the Department of Medicine, Medicine, Cardiology, Medicine 2003
• Research
• 

  Selected Grants

  • Depression and Heart Failure Disease Progression awarded by National Institutes of Health 2014 - 2019
  • Thrombosis and Hemostasis Centers Research and Prevention Network awarded by Centers for Disease Control and Prevention 2002 - 2013
  • Genetics Myocardial Adverse Outcomes/Graft Failure-CABG (Gene-Magic) awarded by National Institutes of Health 2004 - 2011
  • Integrated Program for Persons with Hemostatic Disorders awarded by Centers for Disease Control 2001 - 2007
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Lanfear, David E., Jasmine A. Luzum, Ruicong She, Hongsheng Gui, Mark P. Donahue, Christopher M. O’Connor, Kirkwood F. Adams, et al. “Polygenic Score for β-Blocker Survival Benefit in European Ancestry Patients With Reduced Ejection Fraction Heart Failure.” Circ Heart Fail 13, no. 12 (December 2020): e007012. https://doi.org/10.1161/CIRCHEARTFAILURE.119.007012.
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    • O’Malley, Patrick G., Michael J. Arnold, Cathy Kelley, Lance Spacek, Andrew Buelt, Sundar Natarajan, Mark P. Donahue, et al. “Management of Dyslipidemia for Cardiovascular Disease Risk Reduction: Synopsis of the 2020 Updated U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guideline.” Ann Intern Med 173, no. 10 (November 17, 2020): 822–29. https://doi.org/10.7326/M20-4648.
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    • Reston, James T., Andrew Buelt, Mark P. Donahue, Brian Neubauer, Elena Vagichev, and Kristy McShea. “Interventions to Improve Statin Tolerance and Adherence in Patients at Risk for Cardiovascular Disease : A Systematic Review for the 2020 U.S. Department of Veterans Affairs and U.S. Department of Defense Guidelines for Management of Dyslipidemia.” Ann Intern Med 173, no. 10 (November 17, 2020): 806–12. https://doi.org/10.7326/M20-4680.
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    • Rymer, Jennifer A., Colin I. O’Donnell, Mary E. Plomondon, Paul L. Hess, Mark Donahue, Paul L. Hebert, Adhir Shroff, et al. “Same-day discharge among patients undergoing elective PCI: Insights from the VA CART Program.” Am Heart J 218 (December 2019): 75–83. https://doi.org/10.1016/j.ahj.2019.09.003.
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    • Xu, Huichun, Gerald W. Dorn, Amol Shetty, Ankita Parihar, Tushar Dave, Shawn W. Robinson, Stephen S. Gottlieb, et al. “A Genome-Wide Association Study of Idiopathic Dilated Cardiomyopathy in African Americans.” J Pers Med 8, no. 1 (February 26, 2018). https://doi.org/10.3390/jpm8010011.
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    • Lewis, Lauren S., Kim M. Huffman, Ira J. Smith, Mark P. Donahue, Cris A. Slentz, Joseph A. Houmard, Monica J. Hubal, et al. “Genetic Variation in Acid Ceramidase Predicts Non-completion of an Exercise Intervention.” Front Physiol 9 (2018): 781. https://doi.org/10.3389/fphys.2018.00781.
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    • Sharma, Abhinav, Susanna R. Stevens, Joseph Lucas, Mona Fiuzat, Kirkwood F. Adams, David J. Whellan, Mark P. Donahue, et al. “Utility of Growth Differentiation Factor-15, A Marker of Oxidative Stress and Inflammation, in Chronic Heart Failure: Insights From the HF-ACTION Study.” Jacc Heart Fail 5, no. 10 (October 2017): 724–34. https://doi.org/10.1016/j.jchf.2017.07.013.
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    • Pokorney, Sean D., Jonathan P. Piccini, Susanna R. Stevens, Manesh R. Patel, Karen S. Pieper, Jonathan L. Halperin, Günter Breithardt, et al. “Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation: Data From ROCKET AF.” J Am Heart Assoc 5, no. 3 (March 8, 2016): e002197. https://doi.org/10.1161/JAHA.115.002197.
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    • Ahmad, Tariq, Jacob P. Kelly, Robert W. McGarrah, Anne S. Hellkamp, Mona Fiuzat, Jeffrey M. Testani, Teresa S. Wang, et al. “Prognostic Implications of Long-Chain Acylcarnitines in Heart Failure and Reversibility With Mechanical Circulatory Support.” J Am Coll Cardiol 67, no. 3 (January 26, 2016): 291–99. https://doi.org/10.1016/j.jacc.2015.10.079.
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    • Boggan, Joel C., Ryan D. Schulteis, Mark Donahue, and David L. Simel. “Guideline-based decision support has a small, non-sustained effect on transthoracic echocardiography ordering frequency.” Bmj Qual Saf 25, no. 1 (January 2016): 57–62. https://doi.org/10.1136/bmjqs-2015-004284.
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    • Kraus, William E., Christopher B. Granger, Michael H. Sketch, Mark P. Donahue, Geoffrey S. Ginsburg, Elizabeth R. Hauser, Carol Haynes, et al. “A Guide for a Cardiovascular Genomics Biorepository: the CATHGEN Experience.” J Cardiovasc Transl Res 8, no. 8 (November 2015): 449–57. https://doi.org/10.1007/s12265-015-9648-y.
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    • Ahmad, Tariq, Emily C. O’Brien, Phillip J. Schulte, Susanna R. Stevens, Mona Fiuzat, Dalane W. Kitzman, Kirkwood F. Adams, et al. “Evaluation of the Incremental Prognostic Utility of Increasingly Complex Testing in Chronic Heart Failure.” Circ Heart Fail 8, no. 4 (July 2015): 709–16. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001996.
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    • Ahmad, Tariq, Mona Fiuzat, Benjamin Neely, Megan L. Neely, Michael J. Pencina, William E. Kraus, Faiez Zannad, et al. “Biomarkers of myocardial stress and fibrosis as predictors of mode of death in patients with chronic heart failure.” Jacc Heart Fail 2, no. 3 (June 2014): 260–68. https://doi.org/10.1016/j.jchf.2013.12.004.
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    • Ahmad, Tariq, Mona Fiuzat, Daniel B. Mark, Ben Neely, Megan Neely, William E. Kraus, Dalane W. Kitzman, et al. “The effects of exercise on cardiovascular biomarkers in patients with chronic heart failure.” Am Heart J 167, no. 2 (February 2014): 193-202.e1. https://doi.org/10.1016/j.ahj.2013.10.018.
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    • Fiuzat, Mona, Phillip J. Schulte, Michael Felker, Tariq Ahmad, Megan Neely, Kirkwood F. Adams, Mark P. Donahue, et al. “Relationship between galectin-3 levels and mineralocorticoid receptor antagonist use in heart failure: analysis from HF-ACTION.” J Card Fail 20, no. 1 (January 2014): 38–44. https://doi.org/10.1016/j.cardfail.2013.11.011.
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    • Felker, G Michael, Mona Fiuzat, Vivian Thompson, Linda K. Shaw, Megan L. Neely, Kirkwood F. Adams, David J. Whellan, et al. “Soluble ST2 in ambulatory patients with heart failure: Association with functional capacity and long-term outcomes.” Circ Heart Fail 6, no. 6 (November 2013): 1172–79. https://doi.org/10.1161/CIRCHEARTFAILURE.113.000207.
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    • Fiuzat, Mona, Megan L. Neely, Aijing Z. Starr, William E. Kraus, G Michael Felker, Mark Donahue, Kirkwood Adams, Ileana L. Piña, David Whellan, and Christopher M. O’Connor. “Association between adrenergic receptor genotypes and beta-blocker dose in heart failure patients: analysis from the HF-ACTION DNA substudy.” Eur J Heart Fail 15, no. 3 (March 2013): 258–66. https://doi.org/10.1093/eurjhf/hfs175.
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    • Felker, G Michael, Mona Fiuzat, Linda K. Shaw, Robert Clare, David J. Whellan, Luca Bettari, Shailesh C. Shirolkar, et al. “Galectin-3 in ambulatory patients with heart failure: results from the HF-ACTION study.” Circ Heart Fail 5, no. 1 (January 2012): 72–78. https://doi.org/10.1161/CIRCHEARTFAILURE.111.963637.
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    • Felker, G Michael, David Whellan, William E. Kraus, Robert Clare, Faiez Zannad, Mark Donahue, Kirkwood Adams, et al. “N-terminal pro-brain natriuretic peptide and exercise capacity in chronic heart failure: data from the Heart Failure and a Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) study.” Am Heart J 158, no. 4 Suppl (October 2009): S37–44. https://doi.org/10.1016/j.ahj.2009.07.011.
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    • Sinnaeve, Peter R., Mark P. Donahue, Peter Grass, David Seo, Jacky Vonderscher, Salah-Dine Chibout, William E. Kraus, et al. “Gene expression patterns in peripheral blood correlate with the extent of coronary artery disease.” Plos One 4, no. 9 (September 14, 2009): e7037. https://doi.org/10.1371/journal.pone.0007037.
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    • Fiuzat, Mona, G Michael Felker, Mark P. Donahue, and Christopher M. O’Connor. “Using genetic information to select treatment for patients with heart failure: has the time come?” Per Med 6, no. 4 (July 2009): 385–92. https://doi.org/10.2217/pme.09.19.
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    • Sehnert, Amy J., Susan E. Daniels, Michael Elashoff, James A. Wingrove, Christopher R. Burrow, Benjamin Horne, Joseph B. Muhlestein, et al. “Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol.” J Am Coll Cardiol 52, no. 8 (August 19, 2008): 644–51. https://doi.org/10.1016/j.jacc.2008.05.022.
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    • Donahue, Mark P., and William E. Kraus. “Genetic association studies; the good, the bad, and the ugly.” Am Heart J 154, no. 4 (October 2007): 610–12. https://doi.org/10.1016/j.ahj.2007.06.022.
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    • Donahue, M. P., D. A. Marchuk, and H. A. Rockman. “Reply.” Journal of the American College of Cardiology 49, no. 10 (March 13, 2007): 1106–7. https://doi.org/10.1016/j.jacc.2006.12.019.
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    • Donahue, Mark P., Douglas A. Marchuk, and Howard A. Rockman. “Redefining heart failure: the utility of genomics.” J Am Coll Cardiol 48, no. 7 (October 3, 2006): 1289–98. https://doi.org/10.1016/j.jacc.2006.05.062.
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    • Donahue, Mark P., Keith Rose, Denis Hochstrasser, Jacky Vonderscher, Peter Grass, Salah-Dine Chibout, Charlotte L. Nelson, Peter Sinnaeve, Pascal J. Goldschmidt-Clermont, and Christopher B. Granger. “Discovery of proteins related to coronary artery disease using industrial-scale proteomics analysis of pooled plasma.” Am Heart J 152, no. 3 (September 2006): 478–85. https://doi.org/10.1016/j.ahj.2006.03.007.
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    • Bensimhon, Daniel R., William E. Kraus, and Mark P. Donahue. “Obesity and physical activity: a review.” Am Heart J 151, no. 3 (March 2006): 598–603. https://doi.org/10.1016/j.ahj.2005.03.005.
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    • DeWald, Tracy, Lalita Khaodhiar, Mark P. Donahue, and George Blackburn. “Pharmacological and surgical treatments for obesity.” Am Heart J 151, no. 3 (March 2006): 604–24. https://doi.org/10.1016/j.ahj.2005.03.007.
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    • Patel, Manesh R., Mark Donahue, Peter W. F. Wilson, and Robert M. Califf. “Clinical trial issues in weight-loss therapy.” Am Heart J 151, no. 3 (March 2006): 633–42. https://doi.org/10.1016/j.ahj.2005.03.006.
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    • Ginsburg, Geoffrey S., Mark P. Donahue, and L Kristin Newby. “Prospects for personalized cardiovascular medicine: the impact of genomics.” J Am Coll Cardiol 46, no. 9 (November 1, 2005): 1615–27. https://doi.org/10.1016/j.jacc.2005.06.075.
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    • Donahue, Mark P., and Andrew S. Allen. “Genetic association studies in cardiology.” Am Heart J 149, no. 6 (June 2005): 964–70. https://doi.org/10.1016/j.ahj.2005.03.011.
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    • Dery, Jean-Pierre, Adrian F. Hernandez, Joseph D. Kay, John L. Petersen, Sunil V. Rao, Abdallah G. Rebeiz, Kanwar P. Singh, Mark P. Donahue, and Mark P. American Heart Association. “Highlights from the American Heart Association annual scientific sessions 2002: November 17 to 20, 2002.” Am Heart J 145, no. 3 (March 2003): 554–62. https://doi.org/10.1067/mhj.2003.188.
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    • Le Corvoisier, P., H. Y. Park, K. M. Carlson, M. P. Donahue, D. A. Marchuk, and H. A. Rockman. “Impact of genetic polymorphisms on heart failure prognosis.” Arch Mal Coeur Vaiss 96, no. 3 (March 2003): 197–206.
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    • Donahue, Mark, William Kraus, and Christopher Granger. “Genetics in heart failure: practical incorporation of this new biologic dimension.” Am Heart J 144, no. 6 (December 2002): 938–40. https://doi.org/10.1067/mhj.2002.126738.
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    • Kandzari, David E., Joseph Kay, J Conor O’Shea, Benjamin H. Trichon, Mark Donahue, Lawrence Liao, and Sunil V. Rao. “Highlights from the American Heart Association annual scientific sessions 2001: November 11 to 14, 2001.” Am Heart J 143, no. 2 (February 2002): 217–28. https://doi.org/10.1067/mhj.2002.121794.
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    • Donahue, M., V. Fuster, and R. M. Califf. “Results of Expert Meetings: Obesity and Cardiovascular Disease. Introduction: Cardiologists should target obesity.” Am Heart J 142, no. 6 (December 2001): 1088–90. https://doi.org/10.1067/mhj.2001.119422.
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    • Rao, S. V., M. Donahue, F. X. Pi-Sunyer, and V. Fuster. “Results of Expert Meetings: Obesity and Cardiovascular Disease. Obesity as a risk factor in coronary artery disease.” Am Heart J 142, no. 6 (December 2001): 1102–7. https://doi.org/10.1067/mhj.2001.119419.
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    • Trichon, B. H., J. P. Zidar, T. M. Bashore, M. Donahue, and M. H. Sketch. “Acute myocardial infarction in a young female.” J Invasive Cardiol 13, no. 8 (August 2001): 597–99.
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