Mark Brian Skeen

Journal Article Mult Scler Relat Disord · January 2023 BACKGROUND: Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune neurological disorder associated with antibodies to aquaporin-4 (AQP4). NMOSD has been thought to follow a progressive disease course, with step-wise accumulation of disability ... Full text Open Access Link to item Cite

Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease: Presentation and outcomes of adults at a single center.

Journal Article J Neuroimmunol · December 15, 2022 BACKGROUND/INTRODUCTION: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a chronic demyelinating disorder that has been increasingly recognized since the serum antibody became commercially available in 2017. The most common clini ... Full text Open Access Link to item Cite

Biomarkers and Surrogate End points in Multiple Sclerosis Trials: Regulatory Issues.

Journal Article J Clin Neurophysiol · May 1, 2021 Evoked potentials have assisted in the diagnosis of multiple sclerosis for years, but the potential to demonstrate pathophysiologic change has prompted a reconsideration of their potential role as outcome measures in clinical trials of multiple sclerosis. ... Full text Link to item Cite

Changing Paradigms and Unmet Needs in Multiple Sclerosis: The Role of Clinical Neurophysiology.

Journal Article J Clin Neurophysiol · May 1, 2021 Our increasing understanding of the immunopathogenesis of multiple sclerosis has led to the development of many disease-modifying therapies that have revolutionized the care of patients with relapsing forms of the disease. Our understanding of the pathophy ... Full text Link to item Cite

The Use of Evoked Potentials in Multiple Sclerosis Clinical Trials.

Journal Article J Clin Neurophysiol · May 1, 2021 Full text Link to item Cite

Is Easier Better Than Harder? An Experiment on Choice Experiments for Benefit-Risk Tradeoff Preferences.

Journal Article Med Decis Making · February 2021 OBJECTIVES: To test the convergent validity of simple and more complex study designs in a discrete-choice experiment (DCE) of multiple sclerosis (MS) treatment preferences. METHODS: Five hundred US adults with MS completed an online DCE survey. Respondents ... Full text Link to item Cite

Rapid transfer of knowledge for multiple sclerosis clinical care during COVID-19: ECHO MS.

Journal Article Mult Scler Relat Disord · November 2020 BACKGROUND: Healthcare providers caring for people with multiple sclerosis (MS) have had significant concerns about the intersection of MS and COVID-19. As a result, there has been an urgency to understand and share information about how to best provide MS ... Full text Link to item Cite

The clinical presentation and treatment of MOG antibody disease at a single academic center: A case series.

Journal Article J Neuroimmunol · December 15, 2019 OBJECTIVES: To describe the clinical presentation of MOG antibody disease (MOG-AD) in a series of patients at a single academic center. METHODS: We performed a retrospective review of patients with MOG antibodies. RESULTS: We review the clinical presentati ... Full text Link to item Cite

Recurrent disseminated encephalomyelitis: A case report and literature review.

Journal Article Mult Scler Relat Disord · November 2018 BACKGROUND: Acute disseminated encephalomyelitis has been understood as a monophasic, often post-infectious illness that predominantly affects the pediatric population. Though that describes the majority of cases, exceptions do exist. In this case report, ... Full text Open Access Link to item Cite

Safety and efficacy of opicinumab in acute optic neuritis (RENEW): a randomised, placebo-controlled, phase 2 trial.

Journal Article Lancet Neurol · March 2017 BACKGROUND: The human monoclonal antibody opicinumab (BIIB033, anti-LINGO-1) has shown remyelinating activity in preclinical studies. We therefore assessed the safety and tolerability, and efficacy of opicinumab given soon after a first acute optic neuriti ... Full text Link to item Cite

Electroencephalography leads placed by nontechnologists using a template system produce signals equal in quality to technologist-applied, collodion disk leads.

Journal Article J Clin Neurophysiol · February 2012 The purpose of this study was to compare the quality of the electroencephalographic (EEG) data obtained with a BraiNet template in a practical use setting, to that obtained with standard 10/20 spaced, technologist-applied, collodion-based disk leads. Pairs ... Full text Link to item Cite

Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen.

Journal Article Lancet Neurol · January 2010 BACKGROUND: Some encephalitides or seizure disorders once thought idiopathic now seem to be immune mediated. We aimed to describe the clinical features of one such disorder and to identify the autoantigen involved. METHODS: 15 patients who were suspected t ... Full text Link to item Cite

Subacute combined degeneration due to copper deficiency.

Journal Article J Neuroimaging · October 2007 There is growing clinical evidence supporting a connection between copper deficiency and subacute combined degeneration. While nearly half of patients with copper deficiency myelopathy exhibit MRI abnormalities, signal changes are often ill-defined in dist ... Full text Link to item Cite

Hanging leg syndrome: combined bilateral femoral and sciatic neuropathies.

Journal Article Neurology · April 11, 2006 Full text Link to item Cite

Criteria to determine disability related to multiple sclerosis.

Journal Article Evid Rep Technol Assess (Summ) · May 2004 Link to item Cite

Neurologic manifestations of gastrointestinal disease.

Journal Article Neurol Clin · February 2002 Although previously considered rare, neurologic manifestations of gastrointestinal diseases are increasingly recognized. Understanding of Whipple disease and gluten sensitivity is in transition and these conditions are becoming the province of neurologists ... Full text Link to item Cite

Thoraconeuralgia gravidarum.

Journal Article Muscle Nerve · June 1999 Full text Link to item Cite

Magnetic resonance imaging evidence of hippocampal sclerosis in progression: a case report.

Journal Article Epilepsia · 1994 A 32-month-old child presented in status epilepticus (SE) involving the left side of the body. Fast spin-echo magnetic resonance imaging (FSE-MRI) with hippocampal volumetry performed < or = 24 h after the seizure showed increased T2 signal of the right hi ... Full text Link to item Cite