Mark Chen

Journal Article IEEE Transactions on Radiation and Plasma Medical Sciences · January 1, 2025 Cone-beam CT (CBCT) is commonly used in treatment imaging, but its limited soft tissue contrast presents challenges for liver tumor localization. As a result, indirect localization methods relying on the liver’s boundary are commonly utilized, which have l ... Full text Cite

Tumor genotype dictates radiosensitization after Atm deletion in primary brainstem glioma models.

Journal Article The Journal of clinical investigation · January 2021 Diffuse intrinsic pontine glioma (DIPG) kills more children than any other type of brain tumor. Despite clinical trials testing many chemotherapeutic agents, palliative radiotherapy remains the standard treatment. Here, we utilized Cre/loxP technology to s ... Full text Cite

Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous KrasG12D.

Journal Article Sci Rep · November 20, 2019 Cooperating gene mutations are typically required to transform normal cells enabling growth in soft agar or in immunodeficient mice. For example, mutations in Kras and transformation-related protein 53 (Trp53) are known to transform a variety of mesenchyma ... Full text Open Access Link to item Cite

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Recent Grants

Regulation of oncogenesis and tumor response to radiation therapy by phase separation

ResearchPI-Fellow · Awarded by American Society for Radiation Oncology · 2024 - 2025

Using CRISPR/Cas9 to dissect the role of FUS-CHOP in tumor response to radiation therapy

FellowshipPI-Fellow · Awarded by National Institutes of Health · 2016 - 2020

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