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Mark Chen

Medical Instructor in the Department of Radiation Oncology
Radiation Oncology

Current Duke Appointments & Affiliations


Medical Instructor in the Department of Radiation Oncology · 2026 - Present Radiation Oncology, Clinical Science Departments
Medical Instructor in the Department of Radiation Oncology Biomedical Engineering, Pratt School of Engineering
Medical Instructor in the Department of Radiation Oncology Pharmacology & Cancer Biology, Basic Science Departments
Medical Instructor in the Department of Radiation Oncology Radiation Oncology, Clinical Science Departments

Recent Scholarly Works


Finite Element Method-Based Hybrid MRI/CBCT Generation to Improve Liver Stereotactic Body Radiation Therapy Targets Localization Accuracy.

Journal article IEEE Trans Radiat Plasma Med Sci · March 2025 Cone-beam CT (CBCT) is commonly used in treatment imaging, but its limited soft tissue contrast presents challenges for liver tumor localization. As a result, indirect localization methods relying on the liver's boundary are commonly utilized, which have l ... Full text Link to item Cite

Radiation-Induced Phosphorylation of a Prion-Like Domain Regulates Transformation by FUS-CHOP.

Journal article Cancer Res · October 1, 2021 Chromosomal translocations generate oncogenic fusion proteins in approximately one-third of sarcomas, but how these proteins promote tumorigenesis is not well understood. Interestingly, some translocation-driven cancers exhibit dramatic clinical responses ... Full text Link to item Cite

Tumor genotype dictates radiosensitization after Atm deletion in primary brainstem glioma models.

Journal article J Clin Invest · January 4, 2021 Diffuse intrinsic pontine glioma (DIPG) kills more children than any other type of brain tumor. Despite clinical trials testing many chemotherapeutic agents, palliative radiotherapy remains the standard treatment. Here, we utilized Cre/loxP technology to s ... Full text Link to item Cite
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Recent Grants


Targeting oncogenic transcriptional regulation through biomolecular condensates

ResearchPrincipal Investigator · Awarded by American Society of Clinical Oncology · 2026 - 2027

Regulation of oncogenesis and tumor response to radiation therapy by phase separation

ResearchPI-Fellow · Awarded by American Society for Radiation Oncology · 2024 - 2026

Using CRISPR/Cas9 to dissect the role of FUS-CHOP in tumor response to radiation therapy

FellowshipPI-Fellow · Awarded by National Institutes of Health · 2016 - 2020

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Education


Duke University, School of Medicine · 2021 MD./PhD.