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Martin Fischer

Research Professor in the Department of Chemistry
Box 90346, Durham, NC 27708-0346
2216 French Science Center, 124 Science Drive, Durham, NC 27708


Dr. Fischer’s research focuses on exploring novel nonlinear optical contrast mechanisms for molecular imaging. Nonlinear optical microscopes can provide non-invasive, high-resolution, 3-dimensional images even in highly scattering environments such as biological tissue. Established contrast mechanisms, such as two-photon fluorescence or harmonic generation, can image a range of targets (such as autofluorescent markers or some connective tissue structure), but many of the most molecularly specific nonlinear interactions are harder to measure with power levels one might be willing to put on tissue. In order to use these previously inaccessible interactions as structural and molecular image contrasts we are developing ultrafast laser pulse shaping and pulse shape detection methods that dramatically enhance measurement sensitivity. Applications of these microscopy methods range from imaging biological tissue (mapping structure, endogenous tissue markers, or exogenous contrast agents) to characterization of nanomaterials (such as graphene and gold nanoparticles). The molecular contrast mechanisms we originally developed for biomedical imaging also provide pigment-specific signatures for paints used in historic artwork. Recently we have demonstrated that we can noninvasively image paint layers in historic paintings and we are currently developing microscopy techniques for use in art conservation and conservation science.

Dr. Fischer is also the director of the Advanced Light Imaging and Spectroscopy (ALIS) facility at Duke University.

Current Appointments & Affiliations

Research Professor in the Department of Chemistry · 2022 - Present Chemistry, Trinity College of Arts & Sciences
Research Professor of Physics · 2022 - Present Physics, Trinity College of Arts & Sciences
Faculty Network Member of the Duke Institute for Brain Sciences · 2008 - Present Duke Institute for Brain Sciences, University Institutes and Centers

Education, Training & Certifications

University of Texas, Austin · 2001 Ph.D.
University of Texas, Austin · 1993 M.A.