Current Appointments & Affiliations
Statistician III
Center for Population Health & Aging,
Duke Population Research Institute
Recent Publications
On Approaches to Improve Power in Analyses of Genetic Effects on Time-To-Event Outcomes in Longitudinal Studies
Conference GENETIC EPIDEMIOLOGY · November 1, 2015 Link to item CiteAltered stored calcium release in skeletal myotubes deficient of triadin and junctin.
Journal Article Cell calcium · January 2009 Triadin and junctin are integral sarcoplasmic reticulum membrane proteins that form a macromolecular complex with the skeletal muscle ryanodine receptor (RyR1) but their roles in skeletal muscle calcium homeostasis remain incompletely understood. Here we r ... Full text CiteKnocking down type 2 but not type 1 calsequestrin reduces calcium sequestration and release in C2C12 skeletal muscle myotubes.
Journal Article The Journal of biological chemistry · June 2006 We examined the roles of type 1 and type 2 calsequestrins (CSQ1 and CSQ2) in stored Ca2+ release of C2C12 skeletal muscle myotubes. Transduction of C2C12 myoblasts with CSQ1 or CSQ2 small interfering RNAs effectively reduced the expression of targeted CSQ ... Full text CiteRecent Grants
Leveraging population-based human data to uncover mechanisms connecting Alzheimer's disease and common infections and facilitate vaccines repurposing for AD prevention
ResearchStatistician · Awarded by National Institutes of Health · 2021 - 2026Understanding Alzheimer's Disease in the Context of the Aging
ResearchStatistician · Awarded by National Institutes of Health · 2019 - 2025Genetics of aging, health and longevity: focus on regulatory mechanisms and functional variants connecting aging and Alzheimer's disease"
ResearchStatistician · Awarded by National Institutes of Health · 2020 - 2025View All Grants