Scholars@Duke
Matthew Jacob Boyer

Matthew Jacob Boyer

Assistant Professor of Radiation Oncology
Radiation Oncology
matthew.boyer@duke.edu
Box 3085 Med Ctr, Durham, NC 27710
Duke Cancer Center, Medicine Circle, Box 3085, Durham, NC 27710

Selected Publications

Prognostic significance of magnetic resonance imaging-detected extraprostatic extension in localized prostate cancer.

Journal Article Cancer · December 1, 2025 BACKGROUND: Magnetic resonance imaging (MRI) findings are not currently included in prostate cancer (PC) staging. Yet the presence of MRI-detected extraprostatic extension (EPE) may indicate higher risk disease. The purpose of this study was to assess the ... Full text Link to item Cite

Impact of HIV status on overall survival in head and neck cancers by anatomical site and stage: A multi-center cohort study.

Journal Article Oral Oncol · August 2025 OBJECTIVES: People with human immunodeficiency virus (PWH) are at higher risk for head and neck cancer (HNC) than people without HIV (PWoH), but data on the survival effect of HIV are scarce. The objective is to compare survival for PWH vs. PWoH diagnosed ... Full text Link to item Cite

Genomic classifiers and prognosis of localized prostate cancer: a systematic review.

Journal Article Prostate Cancer Prostatic Dis · March 2025 BACKGROUND: Refinement of the risk classification for localized prostate cancer is warranted to aid in clinical decision making. A systematic analysis was undertaken to evaluate the prognostic ability of three genomic classifiers, Decipher, GPS, and Prolar ... Full text Link to item Cite

Impact of Genomic Classifiers on Risk Stratification and Treatment Intensity in Patients With Localized Prostate Cancer : A Systematic Review.

Journal Article Ann Intern Med · February 2025 BACKGROUND: Tissue-based genomic classifiers (GCs) have been developed to improve prostate cancer (PCa) risk assessment and treatment recommendations. PURPOSE: To summarize the impact of the Decipher, Oncotype DX Genomic Prostate Score (GPS), and Prolaris ... Full text Link to item Cite

Survival and recurrence rates following SBRT or surgery in medically operable Stage I NSCLC.

Journal Article Lung Cancer · November 2024 OBJECTIVES: Surgery is the standard of care for early-stage non-small cell lung cancer (NSCLC), with SBRT reserved for patients who are not surgical candidates. We hypothesized overall survival (OS), lung cancer-specific survival (LCSS), progression free s ... Full text Link to item Cite

Current Strengths and Weaknesses of ChatGPT as a Resource for Radiation Oncology Patients and Providers.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2024 PURPOSE: Chat Generative Pre-Trained Transformer (ChatGPT), an artificial intelligence program that uses natural language processing to generate conversational-style responses to questions or inputs, is increasingly being used by both patients and health c ... Full text Link to item Cite

Radiation technique and outcomes following moderately hypofractionated treatment of low risk prostate cancer: a secondary analysis of RTOG 0415.

Journal Article Prostate Cancer Prostatic Dis · March 2024 BACKGROUND: While moderately hypofractionated radiotherapy (MHRT) for prostate cancer (PC) is commonly delivered by intensity modulated radiation therapy, IMRT has not been prospectively compared to three-dimensional conformal radiotherapy (3D-CRT) in this ... Full text Link to item Cite

Impact of pre-treatment MRI capsular involvement and extraprostatic extension on metastasis free and overall survival in localized prostate cancer

Conference Journal of Clinical Oncology · January 1, 2024 Background: Multiparametric magnetic resonance imaging (mpMRI) is not currently included in prostate cancer (PC) staging. The purpose of this study was to test the association between mpMRI detected prostate capsule involvement and extraprostatic extension ... Full text Cite

Association of multiparametric magnetic resonance imaging findings with oncologic outcomes in non-palpable localized prostate cancer.

Conference Journal of Clinical Oncology · January 1, 2024 Background: Multiparametric magnetic resonance imaging (mpMRI) is becoming increasingly integrated into the evaluation and medical decision making for localized prostate cancer. However, mpMRI findings have not been correlated with prostate cancer outcomes ... Full text Cite

Patient Selection

Chapter · January 1, 2024 Stereotactic body radiotherapy (SBRT) and stereotactic radiosurgery (SRS) techniques can deliver highly conformal ablative doses of radiotherapy to relatively small target volumes. These techniques are associated with excellent rates of local disease contr ... Full text Cite

The 17-Gene Genomic Prostate Score Test Is Prognostic for Outcomes After Primary External Beam Radiation Therapy in Men With Clinically Localized Prostate Cancer.

Journal Article Int J Radiat Oncol Biol Phys · January 1, 2023 PURPOSE: The Oncotype DX Genomic Prostate Score (GPS) assay has been validated as a strong prognostic indicator of adverse pathology, biochemical recurrence, distant metastasis (DM), and prostate cancer (PCa)-related death (PCD) in men with localized PCa a ... Full text Link to item Cite

Toxicity and Outcomes of Moderately Hypofractionated Radiation for Prostate Cancer With Seminal Vesicle Involvement.

Journal Article Adv Radiat Oncol · 2023 PURPOSE: The aim of this study was to assess the toxicity and outcomes following treatment of prostate cancer with seminal vesicle involvement (SVI) evident on magnetic resonance imaging or clinical examination with moderately hypofractionated radiation th ... Full text Link to item Cite

Target Volume Delineation in Non-small Cell Lung Cancer

Chapter · January 1, 2023 Radiation therapy (RT) is an established treatment for all stages of non-small cell lung cancer (NSCLC), from definitive RT for early-stage disease to palliative RT for advanced and metastatic disease. Identifying the appropriate RT target for each patient ... Full text Cite

Comparing Outcomes of Oligometastases Treated with Hypofractionated Image-Guided Radiotherapy (HIGRT) with a Simultaneous Integrated Boost (SIB) Technique versus Metastasis Alone: A Multi-Institutional Analysis.

Journal Article Cancers (Basel) · May 13, 2022 PURPOSE: We previously reported on the clinical outcomes of treating oligometastases with radiation using an elective simultaneous integrated boost technique (SIB), delivering higher doses to known metastases and reduced doses to adjacent bone or nodal bas ... Full text Link to item Cite

Survival Advantage With Adjuvant Chemotherapy for Locoregionally Advanced Rectal Cancer: A Veterans Health Administration Analysis.

Journal Article J Natl Compr Canc Netw · January 2020 BACKGROUND: Adjuvant chemotherapy (AC) after chemoradiation (CRT) and surgery for locoregionally advanced rectal cancer (LARC) is a standard of care in the United States. This study examined the role, optimal regimen, and duration of AC using data from the ... Full text Link to item Cite

Long-term Clinical Outcomes of Nonoperative Management With Chemoradiotherapy for Locally Advanced Rectal Cancer in the Veterans Health Administration.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2019 PURPOSE: Standard therapy for locally advanced rectal cancer includes neoadjuvant chemoradiation and surgery. Complete response (CR) rates after chemoradiation can be as high as 29%, suggesting that nonoperative management (NOM) may be reasonable with appr ... Full text Link to item Cite

Increasing PET Use in Small Cell Lung Cancer: Survival Improvement and Stage Migration in the VA Central Cancer Registry.

Journal Article J Natl Compr Canc Netw · February 2019 Background: Accurate staging for small cell lung cancer (SCLC) is critical for determining appropriate therapy. The clinical impact of increasing PET adoption and stage migration is well described in non-small cell lung cancer but not in SCLC. The objectiv ... Full text Link to item Cite

Improved Survival of Stage I Non-Small Cell Lung Cancer: A VA Central Cancer Registry Analysis.

Journal Article J Thorac Oncol · December 2017 INTRODUCTION: The combined impact of advances in diagnosis and treatment of stage I NSCLC has not been assessed comprehensively. To define the survival impact of modern staging and treatment techniques for clinical stage I NSCLC, the Veterans Administratio ... Full text Link to item Cite

Toxicity and quality of life report of a phase II study of stereotactic body radiotherapy (SBRT) for low and intermediate risk prostate cancer.

Journal Article Radiat Oncol · January 13, 2017 BACKGROUND: Clinical data indicates that delivery of larger daily doses of radiation may improve the therapeutic ratio for prostate cancer compared to conventional fractionation. A phase II study of stereotactic body radiotherapy with real-time motion mana ... Full text Link to item Cite

Toxicity of definitive and post-operative radiation following ipilimumab in non-small cell lung cancer.

Journal Article Lung Cancer · August 2016 To determine the feasibility and toxicity of radiation therapy, delivered either as definitive treatment or following surgery, following neo-adjuvant immune checkpoint inhibition for locally advanced NSCLC sixteen patients who received neo-adjuvant chemoth ... Full text Link to item Cite

Ablative Approaches for Pulmonary Metastases.

Journal Article Thorac Surg Clin · February 2016 Pulmonary metastases are common in patients with cancer for which surgery is considered a standard approach in appropriately selected patients. A number of patients are not candidates for surgery due to a medical comorbidities or the extent of surgery requ ... Full text Link to item Cite

Palliative radiotherapy for prostate cancer.

Journal Article Oncology (Williston Park) · April 2014 Radiotherapy is an effective tool for the palliation of symptoms commonly caused by prostate cancer. The majority of painful bone metastases respond equally well to single or multiple fractions of external radiotherapy. Retreatment with a second course of ... Link to item Cite

Blood vessels engineered from human cells.

Journal Article Lancet · June 18, 2005 Tissue engineering has made considerable progress in the past decade, but advances have stopped short of clinical application for most tissues. We postulated that an obstacle in engineering human tissues is the limited replicative capacity of adult somatic ... Full text Link to item Cite

Human arteries engineered in vitro.

Journal Article EMBO Rep · June 2003 There is a pressing need to develop methods to engineer small-calibre arteries for bypass surgery. We hypothesized that the rate-limiting step that has thwarted previous attempts to engineer such vessels from non-neonatal tissues is the limited proliferati ... Full text Link to item Cite