Scholars@Duke
Matthew Scott McCravy

Matthew Scott McCravy

Medical Instructor in the Department of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine

Selected Publications

Role of Paraoxonase 2 in Airway Epithelial Response to Oxidant Stress.

Journal Article Antioxidants (Basel, Switzerland) · October 2024 Asthma is a widespread chronic lung disease characterized by airway inflammation and hyperresponsiveness. This airway inflammation is classified by either the presence (T2-high) or absence (T2-low) of high levels of eosinophils. Because most therapies for ... Full text Open Access Cite

Predictive signature of murine and human host response to typical and atypical pneumonia.

Journal Article BMJ Open Respir Res · August 3, 2024 BACKGROUND: Pneumonia due to typical bacterial, atypical bacterial and viral pathogens can be difficult to clinically differentiate. Host response-based diagnostics are emerging as a complementary diagnostic strategy to pathogen detection. METHODS: We used ... Full text Link to item Cite

Vertical sleeve gastrectomy associates with airway hyperresponsiveness in a murine model of allergic airway disease and obesity.

Journal Article Front Endocrinol (Lausanne) · 2023 INTRODUCTION: Asthma is a chronic airway inflammatory disease marked by airway inflammation, remodeling and hyperresponsiveness to allergens. Allergic asthma is normally well controlled through the use of beta-2-adrenergic agonists and inhaled corticostero ... Full text Open Access Link to item Cite

Experience With Trauma-Induced ARDS: A Retrospective Study of US Wartime Casualties 2003-2015.

Journal Article J Spec Oper Med · December 16, 2022 BACKGROUND: The purpose of our study was to assess risks/ outcomes of acute respiratory distress syndrome (ARDS) in US combat casualties. We hypothesized that combat trauma patients with ARDS would have worse outcomes based on mechanism of injury (MOI) and ... Full text Link to item Cite

Exogenous leptin enhances markers of airway fibrosis in a mouse model of chronic allergic airways disease.

Journal Article Respir Res · May 24, 2022 BACKGROUND: Asthma patients with comorbid obesity exhibit increased disease severity, in part, due to airway remodeling, which is also observed in mouse models of asthma and obesity. A mediator of remodeling that is increased in obesity is leptin. We hypot ... Full text Open Access Link to item Cite

Wood smoke particle exposure in mice reduces the severity of influenza infection.

Journal Article Toxicol Appl Pharmacol · September 1, 2021 Elevated ambient temperatures and extreme weather events have increased the incidence of wildfires world-wide resulting in increased wood smoke particle (WSP). Epidemiologic data suggests that WSP exposure associates with exacerbations of respiratory disea ... Full text Open Access Link to item Cite

Dysregulated Metabolism in the Pathophysiology of Non-Allergic Obese Asthma.

Journal Article J Asthma Allergy · 2021 Asthma is an obstructive airway disease that is characterized by reversible airway obstruction and is classically associated with atopic, TH2 driven inflammation. Landmark studies in the second half of the twentieth century identified eosinophils as a key ... Full text Open Access Link to item Cite

Bronchoalveolar Tregs are associated with duration of mechanical ventilation in acute respiratory distress syndrome.

Journal Article J Transl Med · November 11, 2020 BACKGROUND: Foxp3+ regulatory T cells (Tregs) play essential roles in immune homeostasis and repair of damaged lung tissue. We hypothesized that patients whose lung injury resolves quickly, as measured by time to liberation from mechanical ventilation, hav ... Full text Open Access Link to item Cite