Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of North Carolina - Chapel Hill 2014
• Research
• 

  Selected Grants

  • Occupational Medicine Program Area of the NC OSHERC awarded by University of North Carolina - Chapel Hill 2017 - 2027
  • Optimization of detection and monitoring of environmental fungal contamination to establish baseline contamination rates (BAA-75D301-22-R-72097 ) awarded by Centers for Disease Control and Prevention 2022 - 2024
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Seidelman, Jessica L., Sarah S. Lewis, Sonali D. Advani, Ibukunoluwa C. Akinboyo, Carol Epling, Matthew Case, Kristen Said, et al. “Universal masking is an effective strategy to flatten the severe acute respiratory coronavirus virus 2 (SARS-CoV-2) healthcare worker epidemiologic curve.” Infect Control Hosp Epidemiol 41, no. 12 (December 2020): 1466–67. https://doi.org/10.1017/ice.2020.313.
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    • Schwartz, Antony, Matthew Stiegel, Nicole Greeson, Andrea Vogel, Wayne Thomann, Monte Brown, Gregory D. Sempowski, et al. “Decontamination and Reuse of N95 Respirators with Hydrogen Peroxide Vapor to Address Worldwide Personal Protective Equipment Shortages During the SARS-CoV-2 (COVID-19) Pandemic.” Appl Biosaf 25, no. 2 (June 1, 2020): 67–70. https://doi.org/10.1177/1535676020919932.
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    • O’Lenick, Cassandra R., Joachim D. Pleil, Matthew A. Stiegel, Jon R. Sobus, and M Ariel Geer Wallace. “Detection and analysis of endogenous polar volatile organic compounds (PVOCs) in urine for human exposome research.” Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals 24, no. 3 (May 2019): 240–48. https://doi.org/10.1080/1354750x.2018.1548031.
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    • Greeson, Nicole Mh, William Mixon, Kirk Huslage, Matthew A. Stiegel, and Wayne R. Thomann. “Quality Control: Hand and Glove Sanitizing in Sterile Compounding, Part 1.” Int J Pharm Compd 23, no. 5 (2019): 387–91.
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    • Greeson, Nicole Mh, William Mixon, Kirk Huslage, Matthew A. Stiegel, and Wayne R. Thomann. “Quality Control: Hand and Glove Sanitizing in Sterile Compounding, Part 2.” Int J Pharm Compd 23, no. 6 (2019): 467–71.
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    • Reyes, Jeanette M., Heidi F. Hubbard, Matthew A. Stiegel, Joachim D. Pleil, and Marc L. Serre. “Predicting polycyclic aromatic hydrocarbons using a mass fraction approach in a geostatistical framework across North Carolina.” Journal of Exposure Science & Environmental Epidemiology 28, no. 4 (June 2018): 381–91. https://doi.org/10.1038/s41370-017-0009-6.
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    • Pleil, Joachim D., M Ariel Geer Wallace, Matthew A. Stiegel, and William E. Funk. “Human biomarker interpretation: the importance of intra-class correlation coefficients (ICC) and their calculations based on mixed models, ANOVA, and variance estimates.” Journal of Toxicology and Environmental Health. Part B, Critical Reviews 21, no. 3 (January 2018): 161–80. https://doi.org/10.1080/10937404.2018.1490128.
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    • Winters, Brett R., Joachim D. Pleil, Michelle M. Angrish, Matthew A. Stiegel, Terence H. Risby, and Michael C. Madden. “Standardization of the collection of exhaled breath condensate and exhaled breath aerosol using a feedback regulated sampling device.” Journal of Breath Research 11, no. 4 (November 2017): 047107. https://doi.org/10.1088/1752-7163/aa8bbc.
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    • Stiegel, Matthew A., Joachim D. Pleil, Jon R. Sobus, Tina Stevens, and Michael C. Madden. “Linking physiological parameters to perturbations in the human exposome: Environmental exposures modify blood pressure and lung function via inflammatory cytokine pathway.” Journal of Toxicology and Environmental Health. Part A 80, no. 9 (January 2017): 485–501. https://doi.org/10.1080/15287394.2017.1330578.
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    • Angrish, Michelle M., Joachim D. Pleil, Matthew A. Stiegel, Michael C. Madden, Virginia C. Moser, and David W. Herr. “Taxonomic applicability of inflammatory cytokines in adverse outcome pathway (AOP) development.” Journal of Toxicology and Environmental Health. Part A 79, no. 4 (January 2016): 184–96. https://doi.org/10.1080/15287394.2016.1138923.
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    • Stiegel, Matthew A., Joachim D. Pleil, Jon R. Sobus, and Michael C. Madden. “Inflammatory Cytokines and White Blood Cell Counts Response to Environmental Levels of Diesel Exhaust and Ozone Inhalation Exposures.” Plos One 11, no. 4 (January 2016): e0152458. https://doi.org/10.1371/journal.pone.0152458.
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    • Stiegel, M. A., J. D. Pleil, J. R. Sobus, M. K. Morgan, and M. C. Madden. “Corrigendum: Analysis of inflammatory cytokines in human blood, breath condensate, and urine using a multiplex immunoassay platform (Biomarkers (2014) 20, 01 DOI: 10.3109/1354750X.2014.988646).” Biomarkers 20, no. 1 (February 1, 2015): e97. https://doi.org/10.3109/1354750X.2015.1006911.
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    • Stiegel, Matthew A., Joachim D. Pleil, Jon R. Sobus, Marsha K. Morgan, and Michael C. Madden. “Analysis of inflammatory cytokines in human blood, breath condensate, and urine using a multiplex immunoassay platform.” Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals 20, no. 1 (February 2015): 35–46. https://doi.org/10.3109/1354750x.2014.988646.
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    • Fent, Kenneth W., Douglas E. Evans, Donald Booher, Joachim D. Pleil, Matthew A. Stiegel, Gavin P. Horn, and James Dalton. “Volatile Organic Compounds Off-gassing from Firefighters' Personal Protective Equipment Ensembles after Use.” Journal of Occupational and Environmental Hygiene 12, no. 6 (January 2015): 404–14. https://doi.org/10.1080/15459624.2015.1025135.
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    • Stiegel, M. A., J. D. Pleil, J. R. Sobus, M. M. Angrish, and M. K. Morgan. “Kidney injury biomarkers and urinary creatinine variability in nominally healthy adults.” Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals 20, no. 6–7 (January 2015): 436–52. https://doi.org/10.3109/1354750x.2015.1094136.
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    • Pleil, Joachim D., Matthew A. Stiegel, and Kenneth W. Fent. “Exploratory breath analyses for assessing toxic dermal exposures of firefighters during suppression of structural burns.” Journal of Breath Research 8, no. 3 (September 2014): 037107. https://doi.org/10.1088/1752-7155/8/3/037107.
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    • Fent, Kenneth W., Judith Eisenberg, John Snawder, Deborah Sammons, Joachim D. Pleil, Matthew A. Stiegel, Charles Mueller, Gavin P. Horn, and James Dalton. “Systemic exposure to PAHs and benzene in firefighters suppressing controlled structure fires.” The Annals of Occupational Hygiene 58, no. 7 (August 2014): 830–45. https://doi.org/10.1093/annhyg/meu036.
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    • Pleil, Joachim D., Jon R. Sobus, Matthew A. Stiegel, Di Hu, Karen D. Oliver, Cassandra Olenick, Mark Strynar, Mary Clark, Michael C. Madden, and William E. Funk. “Estimating common parameters of lognormally distributed environmental and biomonitoring data: harmonizing disparate statistics from publications.” Journal of Toxicology and Environmental Health. Part B, Critical Reviews 17, no. 6 (January 2014): 341–68. https://doi.org/10.1080/10937404.2014.956854.
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    • Pleil, Joachim D., and Matthew A. Stiegel. “Evolution of environmental exposure science: using breath-borne biomarkers for "discovery" of the human exposome.” Analytical Chemistry 85, no. 21 (November 2013): 9984–90. https://doi.org/10.1021/ac402306f.
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    • Ghimenti, S., F. Di Francesco, M. Onor, M. A. Stiegel, M. G. Trivella, C. Comite, N. Catania, R. Fuoco, and J. D. Pleil. “Post-operative elimination of sevoflurane anesthetic and hexafluoroisopropanol metabolite in exhaled breath: pharmacokinetic models for assessing liver function.” Journal of Breath Research 7, no. 3 (September 2013): 036001. https://doi.org/10.1088/1752-7155/7/3/036001.
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    • Pleil, Joachim D., Matthew A. Stiegel, and Terence H. Risby. “Clinical breath analysis: discriminating between human endogenous compounds and exogenous (environmental) chemical confounders.” Journal of Breath Research 7, no. 1 (March 2013): 017107. https://doi.org/10.1088/1752-7155/7/1/017107.
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    • Bereznicki, S. D., J. R. Sobus, A. F. Vette, M. A. Stiegel, and R. W. Williams. “Assessing spatial and temporal variability of VOCs and PM-components in outdoor air during the Detroit Exposure and Aerosol Research Study (DEARS).” Atmospheric Environment 61 (December 1, 2012): 159–68. https://doi.org/10.1016/j.atmosenv.2012.07.008.
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    • Pleil, Joachim D., Matthew A. Stiegel, Tzipporah M. Kormos, and Jon R. Sobus. “Breath analysis science at PittCon 2012, Orlando, Florida.” Journal of Breath Research 6, no. 3 (September 2012): 039001. https://doi.org/10.1088/1752-7155/6/3/039001.
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    • Pleil, Joachim D., Matthew A. Stiegel, and Jon R. Sobus. “Breath biomarkers in environmental health science: exploring patterns in the human exposome.” Journal of Breath Research 5, no. 4 (December 2011): 046005. https://doi.org/10.1088/1752-7155/5/4/046005.
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    • Pleil, Joachim D., Matthew A. Stiegel, Jon R. Sobus, Qian Liu, and Michael C. Madden. “Observing the human exposome as reflected in breath biomarkers: heat map data interpretation for environmental and intelligence research.” Journal of Breath Research 5, no. 3 (September 2011): 037104. https://doi.org/10.1088/1752-7155/5/3/037104.
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    • Pleil, Joachim D., Matthew A. Stiegel, Michael C. Madden, and Jon R. Sobus. “Heat map visualization of complex environmental and biomarker measurements.” Chemosphere 84, no. 5 (July 2011): 716–23. https://doi.org/10.1016/j.chemosphere.2011.03.017.
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    • Pleil, J. D., M. A. Stiegel, J. R. Sobus, S. Tabucchi, A. J. Ghio, and M. C. Madden. “Cumulative exposure assessment for trace-level polycyclic aromatic hydrocarbons (PAHs) using human blood and plasma analysis.” Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 878, no. 21 (July 2010): 1753–60. https://doi.org/10.1016/j.jchromb.2010.04.035.
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    • Alderman, T. S., M. A. Stiegel, R. A. Estes, and G. D. Sempowski. “Field-Testing Method for Loose-Fitting Powered Air-Purifying Respirators Equipped with HEPA Filters,,” n.d.
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  • Conference Papers

    • Pleil, Joachim D., Wolfram Miekisch, Matthew A. Stiegel, and Jonathan Beauchamp. “Extending breath analysis to the cellular level: current thoughts on the human microbiome and the expression of organic compounds in the human exposome.” In Journal of Breath Research, 8:029001, 2014. https://doi.org/10.1088/1752-7155/8/2/029001.
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    • Stiegel, Matthew A., Jon R. Sobus, Michael C. Madden, and Joachim D. Pleil. “Combining data visualization and statistical approaches for interpreting measurements and meta-data: Integrating heatmaps, variable clustering, and mixed regression models.” In Abstracts of Papers of the American Chemical Society, Vol. 248, 2014.
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    • Madden, M. C., T. Stevens, M. Case, J. Sobus, M. Stiegel, D. Diaz-Sanchez, W. Cascio, R. B. Devlin, and J. D. Pleil. “CONTROLLED EXPOSURES OF HUMAN VOLUNTEERS TO DIESEL ENGINE EXHAUST: BIOMARKERS OF EXPOSURE AND HEALTH OUTCOMES.” In Journal of Aerosol Medicine and Pulmonary Drug Delivery, 26:A6–7, 2013.
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