Matthew Waitkus | Scholars@Duke

Matthew Waitkus
Medical Instructor in the Department of Neurosurgery

Current Appointments & Affiliations

Medical Instructor in the Department of Neurosurgery, Neurosurgery, Neurosurgery 2020
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2020

Contact Information

203 Research Drive, Durham, NC 27705
DUMC 2600, 203 Research Drive, Room 155, Durham, NC 27710
matthew.waitkus@duke.edu (919) 613-3697

Background
Education, Training, & Certifications
- Ph.D., Cleveland State University 2014
Duke Appointment History
- Medical Instructor in the Department of Pathology, Pathology, Clinical Science Departments 2016 - 2020
Research
Selected Grants
- Synthetic lethal strategies for targeting ATRX deficiency and the Alternative Lengthening of Telomeres in Pediatric High-Grade Gliomas awarded by Uncle Kory Foundation 2020 - 2021
- Role of GLUD2 as a metabolic driver of gliomas with IDH1 mutations awarded by National Institutes of Health 2016 - 2021
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Waitkus, Matthew S., and Hai Yan. “Targeting Isocitrate Dehydrogenase Mutations in Cancer: Emerging Evidence and Diverging Strategies.” Clin Cancer Res 27, no. 2 (January 15, 2021): 383–88. https://doi.org/10.1158/1078-0432.CCR-20-1827.
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  - Wang, Zhaohui, Cheng Xu, Bill H. Diplas, Casey J. Moure, Chin-Pu Jason Chen, Lee H. Chen, Changzheng Du, et al. “Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib.” Mol Cancer Res 18, no. 7 (July 2020): 968–80. https://doi.org/10.1158/1541-7786.MCR-19-0507.
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  - Chen, Lee H., Changcun Pan, Bill H. Diplas, Cheng Xu, Landon J. Hansen, Yuliang Wu, Xin Chen, et al. “The integrated genomic and epigenomic landscape of brainstem glioma.” Nat Commun 11, no. 1 (June 17, 2020): 3077. https://doi.org/10.1038/s41467-020-16682-y.
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  - Moure, Casey J., Bill H. Diplas, Lee H. Chen, Rui Yang, Christopher J. Pirozzi, Zhaohui Wang, Ivan Spasojevic, Matthew S. Waitkus, Yiping He, and Hai Yan. “CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP.” Mol Cancer Res 17, no. 10 (October 2019): 2042–50. https://doi.org/10.1158/1541-7786.MCR-19-0309.
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  - Liu, Yang, Austin B. Carpenter, Christopher J. Pirozzi, Hsiangkuo Yuan, Matthew S. Waitkus, Zhengyuan Zhou, Landon Hansen, et al. “Non-invasive sensitive brain tumor detection using dual-modality bioimaging nanoprobe.” Nanotechnology 30, no. 27 (July 5, 2019): 275101. https://doi.org/10.1088/1361-6528/ab0e9c.
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  - Baig, Shahid Mahmood, Ambrin Fatima, Muhammad Tariq, Tahir Naeem Khan, Zafar Ali, Mohammad Faheem, Humera Mahmood, et al. “Hereditary brain tumor with a homozygous germline mutation in PMS2: pedigree analysis and prenatal screening in a family with constitutional mismatch repair deficiency (CMMRD) syndrome.” Fam Cancer 18, no. 2 (April 2019): 261–65. https://doi.org/10.1007/s10689-018-0112-4.
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  - Diplas, Bill H., Heng Liu, Rui Yang, Landon J. Hansen, Alexis L. Zachem, Fangping Zhao, Darell D. Bigner, et al. “Sensitive and rapid detection of TERT promoter and IDH mutations in diffuse gliomas.” Neuro Oncol 21, no. 4 (March 18, 2019): 440–50. https://doi.org/10.1093/neuonc/noy167.
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  - Waitkus, Matthew S., Bill H. Diplas, and Hai Yan. “Biological Role and Therapeutic Potential of IDH Mutations in Cancer.” Cancer Cell 34, no. 2 (August 13, 2018): 186–95. https://doi.org/10.1016/j.ccell.2018.04.011.
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  - Diplas, Bill H., Xujun He, Jacqueline A. Brosnan-Cashman, Heng Liu, Lee H. Chen, Zhaohui Wang, Casey J. Moure, et al. “The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma.” Nat Commun 9, no. 1 (May 25, 2018): 2087. https://doi.org/10.1038/s41467-018-04448-6.
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  - Waitkus, Matthew S., Christopher J. Pirozzi, Casey J. Moure, Bill H. Diplas, Landon J. Hansen, Austin B. Carpenter, Rui Yang, et al. “Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities.” Cancer Res 78, no. 1 (January 1, 2018): 36–50. https://doi.org/10.1158/0008-5472.CAN-17-1352.
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  - Yang, Rui, Lee H. Chen, Landon J. Hansen, Austin B. Carpenter, Casey J. Moure, Heng Liu, Christopher J. Pirozzi, et al. “Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation.” Cancer Res 77, no. 22 (November 15, 2017): 6097–6108. https://doi.org/10.1158/0008-5472.CAN-17-1018.
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  - Pirozzi, Christopher J., Austin B. Carpenter, Matthew S. Waitkus, Catherine Y. Wang, Huishan Zhu, Landon J. Hansen, Lee H. Chen, et al. “Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression.” Mol Cancer Res 15, no. 5 (May 2017): 507–20. https://doi.org/10.1158/1541-7786.MCR-16-0485.
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  - Waitkus, Matthew S., Bill H. Diplas, and Hai Yan. “Isocitrate dehydrogenase mutations in gliomas.” Neuro Oncol 18, no. 1 (January 2016): 16–26. https://doi.org/10.1093/neuonc/nov136.
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  - Boerckel, Joel D., Unnikrishnan M. Chandrasekharan, Matthew S. Waitkus, Emily G. Tillmaand, Rebecca Bartlett, and Paul E. Dicorleto. “Mitogen-activated protein kinase phosphatase-1 promotes neovascularization and angiogenic gene expression.” Arterioscler Thromb Vasc Biol 34, no. 5 (May 2014): 1020–31. https://doi.org/10.1161/ATVBAHA.114.303403.
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  - Waitkus, Matthew S., Unni M. Chandrasekharan, Belinda Willard, Thomas L. Tee, Jason K. Hsieh, Christopher G. Przybycin, Brian I. Rini, and Paul E. Dicorleto. “Signal integration and gene induction by a functionally distinct STAT3 phosphoform.” Mol Cell Biol 34, no. 10 (May 2014): 1800–1811. https://doi.org/10.1128/MCB.00034-14.
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  - Chandrasekharan, Unni M., Lisa Dechert, Uchechukwu I. Davidson, Matthew Waitkus, Lori Mavrakis, Katherine Lyons, Jordan R. Beach, et al. “Release of nonmuscle myosin II from the cytosolic domain of tumor necrosis factor receptor 2 is required for target gene expression.” Sci Signal 6, no. 284 (July 16, 2013): ra60. https://doi.org/10.1126/scisignal.2003743.
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  - Waitkus, Matthew S., Unni M. Chandrasekharan, Belinda Willard, S Jaharul Haque, and Paul E. DiCorleto. “STAT3-mediated coincidence detection regulates noncanonical immediate early gene induction.” J Biol Chem 288, no. 17 (April 26, 2013): 11988–3. https://doi.org/10.1074/jbc.M112.428516.
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  - Chandrasekharan, Unni M., Matthew Waitkus, Corttrell M. Kinney, Alicia Walters-Stewart, and Paul E. DiCorleto. “Synergistic induction of mitogen-activated protein kinase phosphatase-1 by thrombin and epidermal growth factor requires vascular endothelial growth factor receptor-2.” Arterioscler Thromb Vasc Biol 30, no. 10 (October 2010): 1983–89. https://doi.org/10.1161/ATVBAHA.110.212399.
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- Book Sections
  - Waitkus, Matthew S., Daniel P. Harris, and Paul E. DiCorleto. “Mechanisms of Endothelial Activation.” In Encyclopedia of Medical Immunology, 715–24. Springer New York, 2014. https://doi.org/10.1007/978-0-387-84828-0_183.
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Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles

Book Sections

Recent Courses