Matthew Waitkus
Assistant Professor in Neurosurgery
Current Appointments & Affiliations
- Assistant Professor in Neurosurgery, Neurosurgery, Neurosurgery 2021
- Assistant Professor of Pathology, Pathology, Clinical Science Departments 2021
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2020
Contact Information
- 203 Research Drive, Durham, NC 27705
- DUMC 2600, 203 Research Drive, Room 155, Durham, NC 27710
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matthew.waitkus@duke.edu
(919) 613-3697
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The Waitkus Lab at Duke
- Background
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Education, Training, & Certifications
- Ph.D., Cleveland State University 2014
- M.S., The Ohio State University College of Medicine 2009
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Previous Appointments & Affiliations
- Medical Instructor in the Department of Neurosurgery, Neurosurgery, Neurosurgery 2020 - 2021
- Medical Instructor in the Department of Pathology, Pathology, Clinical Science Departments 2016 - 2020
- Research
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Selected Grants
- The role of SMARCAL1 in glioma telomere maintenance. awarded by National Institutes of Health 2022 - 2025
- Synthetic lethal strategies for targeting ATRX deficiency and the Alternative Lengthening of Telomeres in Pediatric High-Grade Gliomas awarded by Uncle Kory Foundation 2020 - 2022
- Role of GLUD2 as a metabolic driver of gliomas with IDH1 mutations awarded by National Institutes of Health 2016 - 2020
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Waitkus, Matthew S., and Hai Yan. “Targeting Isocitrate Dehydrogenase Mutations in Cancer: Emerging Evidence and Diverging Strategies.” Clin Cancer Res 27, no. 2 (January 15, 2021): 383–88. https://doi.org/10.1158/1078-0432.CCR-20-1827.Full Text Link to Item
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Wang, Zhaohui, Cheng Xu, Bill H. Diplas, Casey J. Moure, Chin-Pu Jason Chen, Lee H. Chen, Changzheng Du, et al. “Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib.” Mol Cancer Res 18, no. 7 (July 2020): 968–80. https://doi.org/10.1158/1541-7786.MCR-19-0507.Full Text Link to Item
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Chen, Lee H., Changcun Pan, Bill H. Diplas, Cheng Xu, Landon J. Hansen, Yuliang Wu, Xin Chen, et al. “The integrated genomic and epigenomic landscape of brainstem glioma.” Nat Commun 11, no. 1 (June 17, 2020): 3077. https://doi.org/10.1038/s41467-020-16682-y.Full Text Link to Item
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Moure, Casey J., Bill H. Diplas, Lee H. Chen, Rui Yang, Christopher J. Pirozzi, Zhaohui Wang, Ivan Spasojevic, Matthew S. Waitkus, Yiping He, and Hai Yan. “CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP.” Mol Cancer Res 17, no. 10 (October 2019): 2042–50. https://doi.org/10.1158/1541-7786.MCR-19-0309.Full Text Link to Item
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Liu, Yang, Austin B. Carpenter, Christopher J. Pirozzi, Hsiangkuo Yuan, Matthew S. Waitkus, Zhengyuan Zhou, Landon Hansen, et al. “Non-invasive sensitive brain tumor detection using dual-modality bioimaging nanoprobe.” Nanotechnology 30, no. 27 (July 5, 2019): 275101. https://doi.org/10.1088/1361-6528/ab0e9c.Full Text Link to Item
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Baig, Shahid Mahmood, Ambrin Fatima, Muhammad Tariq, Tahir Naeem Khan, Zafar Ali, Mohammad Faheem, Humera Mahmood, et al. “Hereditary brain tumor with a homozygous germline mutation in PMS2: pedigree analysis and prenatal screening in a family with constitutional mismatch repair deficiency (CMMRD) syndrome.” Fam Cancer 18, no. 2 (April 2019): 261–65. https://doi.org/10.1007/s10689-018-0112-4.Full Text Link to Item
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Diplas, Bill H., Heng Liu, Rui Yang, Landon J. Hansen, Alexis L. Zachem, Fangping Zhao, Darell D. Bigner, et al. “Sensitive and rapid detection of TERT promoter and IDH mutations in diffuse gliomas.” Neuro Oncol 21, no. 4 (March 18, 2019): 440–50. https://doi.org/10.1093/neuonc/noy167.Full Text Link to Item
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Waitkus, Matthew S., Bill H. Diplas, and Hai Yan. “Biological Role and Therapeutic Potential of IDH Mutations in Cancer.” Cancer Cell 34, no. 2 (August 13, 2018): 186–95. https://doi.org/10.1016/j.ccell.2018.04.011.Full Text Link to Item
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Diplas, Bill H., Xujun He, Jacqueline A. Brosnan-Cashman, Heng Liu, Lee H. Chen, Zhaohui Wang, Casey J. Moure, et al. “The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma.” Nat Commun 9, no. 1 (May 25, 2018): 2087. https://doi.org/10.1038/s41467-018-04448-6.Full Text Link to Item
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Waitkus, Matthew S., Christopher J. Pirozzi, Casey J. Moure, Bill H. Diplas, Landon J. Hansen, Austin B. Carpenter, Rui Yang, et al. “Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities.” Cancer Res 78, no. 1 (January 1, 2018): 36–50. https://doi.org/10.1158/0008-5472.CAN-17-1352.Full Text Link to Item
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Yang, Rui, Lee H. Chen, Landon J. Hansen, Austin B. Carpenter, Casey J. Moure, Heng Liu, Christopher J. Pirozzi, et al. “Cic Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation.” Cancer Res 77, no. 22 (November 15, 2017): 6097–6108. https://doi.org/10.1158/0008-5472.CAN-17-1018.Full Text Link to Item
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Pirozzi, Christopher J., Austin B. Carpenter, Matthew S. Waitkus, Catherine Y. Wang, Huishan Zhu, Landon J. Hansen, Lee H. Chen, et al. “Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression.” Mol Cancer Res 15, no. 5 (May 2017): 507–20. https://doi.org/10.1158/1541-7786.MCR-16-0485.Full Text Link to Item
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Waitkus, Matthew S., Bill H. Diplas, and Hai Yan. “Isocitrate dehydrogenase mutations in gliomas.” Neuro Oncol 18, no. 1 (January 2016): 16–26. https://doi.org/10.1093/neuonc/nov136.Full Text Link to Item
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Boerckel, Joel D., Unnikrishnan M. Chandrasekharan, Matthew S. Waitkus, Emily G. Tillmaand, Rebecca Bartlett, and Paul E. Dicorleto. “Mitogen-activated protein kinase phosphatase-1 promotes neovascularization and angiogenic gene expression.” Arterioscler Thromb Vasc Biol 34, no. 5 (May 2014): 1020–31. https://doi.org/10.1161/ATVBAHA.114.303403.Full Text Link to Item
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Waitkus, Matthew S., Unni M. Chandrasekharan, Belinda Willard, Thomas L. Tee, Jason K. Hsieh, Christopher G. Przybycin, Brian I. Rini, and Paul E. Dicorleto. “Signal integration and gene induction by a functionally distinct STAT3 phosphoform.” Mol Cell Biol 34, no. 10 (May 2014): 1800–1811. https://doi.org/10.1128/MCB.00034-14.Full Text Link to Item
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Chandrasekharan, Unni M., Lisa Dechert, Uchechukwu I. Davidson, Matthew Waitkus, Lori Mavrakis, Katherine Lyons, Jordan R. Beach, et al. “Release of nonmuscle myosin II from the cytosolic domain of tumor necrosis factor receptor 2 is required for target gene expression.” Sci Signal 6, no. 284 (July 16, 2013): ra60. https://doi.org/10.1126/scisignal.2003743.Full Text Link to Item
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Waitkus, Matthew S., Unni M. Chandrasekharan, Belinda Willard, S Jaharul Haque, and Paul E. DiCorleto. “STAT3-mediated coincidence detection regulates noncanonical immediate early gene induction.” J Biol Chem 288, no. 17 (April 26, 2013): 11988–3. https://doi.org/10.1074/jbc.M112.428516.Full Text Link to Item
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Chandrasekharan, Unni M., Matthew Waitkus, Corttrell M. Kinney, Alicia Walters-Stewart, and Paul E. DiCorleto. “Synergistic induction of mitogen-activated protein kinase phosphatase-1 by thrombin and epidermal growth factor requires vascular endothelial growth factor receptor-2.” Arterioscler Thromb Vasc Biol 30, no. 10 (October 2010): 1983–89. https://doi.org/10.1161/ATVBAHA.110.212399.Full Text Link to Item
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Book Sections
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Waitkus, M., D. Harris, and P. DiCorleto. “Mechanisms of Endothelial Activation,” n.d. https://doi.org/10.1007/978-0-387-84828-0_183.Full Text
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- Teaching & Mentoring
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Recent Courses
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