Skip to main content

Megan Madonna

Assistant Research Professor in the Department of Biomedical Engineering
Biomedical Engineering
140 Science Dr., Gross Hall 379, Durham, NC 27708

Current Duke Appointments & Affiliations


Assistant Research Professor in the Department of Biomedical Engineering · 2023 - Present Biomedical Engineering, Pratt School of Engineering

Recent News Items


Published September 30, 2025
Duke Instructors are Changing the Narrative around Grading at Duke
Published March 28, 2025
Championing Innovative Grading and Assessment at Duke
Published May 8, 2024
Ignite Helps Students Illuminate—and Solve—Problems in Their Own Community

View All News Items

Recent Scholarly Works


In vivo imaging of metabolic heterogeneity across three endpoints relevant to aggressive breast cancer.

Journal article PNAS Nexus · March 2026 Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with poor prognosis and a high likelihood of recurrence. Residual disease after therapy is a key predictor of recurrence, often driven by intratumoral metabolic heterogeneity. A ... Full text Link to item Cite

Multi-probe Metabolic Fluorescence Microscopy Captures Poor Tumor Immunogenicity

Conference Optical Molecular Probes Imaging and Drug Delivery Omp 2025 in Proceedings Optica Biophotonics Congress 2025 Part of Optica Biophotonics Congress Optics in the Life Sciences · January 1, 2025 Visualizing complex tumor-immune metabolic interactions is imperative to understanding cancer progression. Cocultures of 4T1 tumor cells and CD8+ T cells were imaged for glucose uptake and mitochondrial metabolism. Results point to poor immunogenic tumor p ... Full text Cite

Ignite: Place-based Community-centered Design to Promote Biomedical Engineering Efficacy

Conference ASEE Annual Conference and Exposition Conference Proceedings · January 1, 2025 This study evaluates the impact of Ignite’s Health programming, an informal engineering experience designed for middle and high school students and facilitated by Duke University undergraduate students. Participants design health-related projects such as p ... Full text Cite
View All Scholarly Works

Recent Grants


A single shot therapy will accelerate the elimination of breast cancer

ResearchResearch Scientist · Awarded by United States Army Medical Research Acquisition Activity · 2024 - 2028

Development of CapCell Scope for Metabolic Imaging of Tissue Heterogeneity and Therapy Response

ResearchCo Investigator · Awarded by National Institute of Biomedical Imaging and Bioengineering · 2019 - 2028

Ignite: Place-Based Human Centered Design Framework to Promote Engineering and Community-Identity

ResearchPrincipal Investigator · Awarded by Burroughs Wellcome Fund · 2024 - 2027

View All Grants

Education


Duke University · 2020 Ph.D.