Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellowship, Cardiovascular Medicine, Stony Brook University, Renaissance School of Medicine 2008 - 2011
  • Residency, Internal Medicine, Columbia University 2005 - 2008
  • M.D., Yeshiva University, Albert Einstein College of Medicine 2005
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2013 - 2019
  • Medical Instructor in the Department of Medicine, Medicine, Cardiology, Medicine 2011 - 2013
• Recognition
• 

  In the News

  • JAN 20, 2023

    Duke Health News

    Heart Disease: What Women Need to Know

  • FEB 5, 2015

    Poetry Prize; Black History Month: The Week at Duke {in 60 Seconds}
• Research
• 

  Selected Grants

  • Cardiomyopathy associated with Friedreich¿s Ataxia awarded by LEXEO Therapeutics, Inc 2022 - 2029
  • 4D MT - 4D-310_Follow Up - Taiwan awarded by 4D Molecular Therapeutics 2021 - 2028
  • Gene Therapy 4D-310 in Adult Males with Fabry Disease awarded by 4D Molecular Therapeutics 2020 - 2028
  • Coronary Artery Calcium in the PRagmatic EValuation of evENTs And Benefits of Lipid lowering in the Elderly: CAC PREVENTABLE Ancillary Study awarded by National Institutes of Health 2021 - 2026
  • Epidemiologic Determinants of Cardiac Structure and Function in Rural Residents: RURAL ECHO awarded by National Heart, Lung, and Blood Institute 2022 - 2025
  • Prospective Randomized Trial of the Optimal Evaluation of Cardiac Symptoms and Revascularization awarded by HeartFlow, Inc. 2019 - 2024
  • CF-301 Phase III awarded by ContraFect Corporation 2019 - 2023
  • CTEPH AI Project awarded by Bayer HealthCare, LLC 2020 - 2021
• 

  External Relationships

  • Lexeo Therapeutics
  • Zoll LIfeVest
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Lowenstern, Angela, Nicholas Ng, Hidenobu Takagi, Jennifer A. Rymer, Lynne M. Koweek, Pamela S. Douglas, Jessica M. Duran, et al. “Influence of Obesity on Coronary Artery Disease and Clinical Outcomes in the ADVANCE Registry.” Circ Cardiovasc Imaging 16, no. 5 (May 2023): e014850. https://doi.org/10.1161/CIRCIMAGING.122.014850.
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    • Cauwenberghs, Nicholas, Francois Haddad, Melissa A. Daubert, Ranee Chatterjee, Michael Salerno, Jessica L. Mega, Paul Heidenreich, et al. “Clinical and Echocardiographic Diversity Associated With Physical Fitness in the Project Baseline Health Study: Implications for Heart Failure Staging.” J Card Fail, April 26, 2023. https://doi.org/10.1016/j.cardfail.2023.04.008.
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    • Harrington, Josephine, Andrew B. Nixon, Melissa A. Daubert, Eric Yow, James Januzzi, Mona Fiuzat, David J. Whellan, et al. “Circulating Angiokines Are Associated With Reverse Remodeling and Outcomes in Chronic Heart Failure.” J Card Fail, January 8, 2023. https://doi.org/10.1016/j.cardfail.2022.12.011.
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    • Schwartz, Fides R., Melissa A. Daubert, Lior Molvin, Juan C. Ramirez-Giraldo, Ehsan Samei, Daniele Marin, and Tina D. Tailor. “Coronary Artery Calcium Evaluation Using New Generation Photon-counting Computed Tomography Yields Lower Radiation Dose Compared With Standard Computed Tomography.” J Thorac Imaging 38, no. 1 (January 1, 2023): 44–45. https://doi.org/10.1097/RTI.0000000000000685.
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    • Kolte, Dhaval, Bhaskar Bhardwaj, Michael Lu, Maria C. Alu, Jonathan J. Passeri, Ignacio Inglessis, Gus J. Vlahakes, et al. “Association Between Early Left Ventricular Ejection Fraction Improvement After Transcatheter Aortic Valve Replacement and 5-Year Clinical Outcomes.” Jama Cardiol 7, no. 9 (September 1, 2022): 934–44. https://doi.org/10.1001/jamacardio.2022.2222.
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    • Razavi, Alexander C., Arthur S. Agatston, Leslee J. Shaw, Carlo N. De Cecco, Marly van Assen, Laurence S. Sperling, Marcio S. Bittencourt, et al. “Evolving Role of Calcium Density in Coronary Artery Calcium Scoring and Atherosclerotic Cardiovascular Disease Risk.” Jacc Cardiovasc Imaging 15, no. 9 (September 2022): 1648–62. https://doi.org/10.1016/j.jcmg.2022.02.026.
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    • Haddad, Francois, Nicholas Cauwenberghs, Melissa A. Daubert, Yukari Kobayashi, Gerald S. Bloomfield, Dominik Fleischman, Lynne Koweek, et al. “Association of left ventricular diastolic function with coronary artery calcium score: A Project Baseline Health Study.” J Cardiovasc Comput Tomogr 16, no. 6 (2022): 498–508. https://doi.org/10.1016/j.jcct.2022.06.003.
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    • Pahuja, Mohit, Eric S. Leifer, John-Ross D. Clarke, Tariq Ahmad, Melissa A. Daubert, Daniel B. Mark, Lawton Cooper, et al. “Assessing race and ethnicity differences in outcomes based on GDMT and target NT-proBNP in patients with heart failure with reduced ejection fraction: An analysis of the GUIDE-IT study.” Prog Cardiovasc Dis 71 (2022): 79–85. https://doi.org/10.1016/j.pcad.2022.04.010.
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    • Blaha, Michael J., and Melissa A. Daubert. “Assessing the Impact of Coronary Plaque on the Relative and Absolute Risk Reduction With Statin Therapy.” Jacc Cardiovasc Imaging 14, no. 12 (December 2021): 2411–13. https://doi.org/10.1016/j.jcmg.2021.07.005.
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    • Mulrenin, Ian R., Julian E. Garcia, Muluneh M. Fashe, Matthew Shane Loop, Melissa A. Daubert, Rachel Peragallo Urrutia, and Craig R. Lee. “The Impact of Pregnancy on Antihypertensive Drug Metabolism and Pharmacokinetics: Current Status and Future Directions.” Expert Opin Drug Metab Toxicol 17, no. 11 (November 2021): 1261–79. https://doi.org/10.1080/17425255.2021.2002845.
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    • Daubert, Melissa A., Eric Yow, Huiman X. Barnhart, Ileana L. Piña, Tariq Ahmad, Eric Leifer, Lawton Cooper, et al. “Differences in NT-proBNP Response and Prognosis in Men and Women With Heart Failure With Reduced Ejection Fraction.” J Am Heart Assoc 10, no. 10 (May 18, 2021): e019712. https://doi.org/10.1161/JAHA.120.019712.
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    • Daubert, Melissa A., Tina Tailor, Olga James, Leslee J. Shaw, Pamela S. Douglas, and Lynne Koweek. “Multimodality cardiac imaging in the 21st century: evolution, advances and future opportunities for innovation.” Br J Radiol 94, no. 1117 (January 1, 2021): 20200780. https://doi.org/10.1259/bjr.20200780.
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    • Patel, Priyesh A., Cynthia L. Green, Yuliya Lokhnygina, Jared Christensen, Carmelo A. Milano, Joseph G. Rogers, Chetan B. Patel, Lynne M. Koweek, and Melissa A. Daubert. “Cardiac computed tomography improves the identification of cardiomechanical complications among patients with suspected left ventricular assist device malfunction.” J Cardiovasc Comput Tomogr 15, no. 3 (2021): 260–67. https://doi.org/10.1016/j.jcct.2020.08.008.
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    • Samei, Ehsan, Taylor Richards, William P. Segars, Melissa A. Daubert, Alex Ivanov, Geoffrey D. Rubin, Pamela S. Douglas, and Udo Hoffmann. “Task-dependent estimability index to assess the quality of cardiac computed tomography angiography for quantifying coronary stenosis.” J Med Imaging (Bellingham) 8, no. 1 (January 2021): 013501. https://doi.org/10.1117/1.JMI.8.1.013501.
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    • Daubert, Melissa A., Eric J. Velazquez, and Tracy Y. Wang. “Implications of ST Changes During Normal Echocardiography-Reply.” Jama Intern Med 180, no. 9 (September 1, 2020): 1257–58. https://doi.org/10.1001/jamainternmed.2020.1844.
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    • Gonzales, Holly, Pamela S. Douglas, Philippe Pibarot, Rebecca T. Hahn, Omar K. Khalique, Wael A. Jaber, Paul Cremer, et al. “Left Ventricular Hypertrophy and Clinical Outcomes Over 5 Years After TAVR: An Analysis of the PARTNER Trials and Registries.” Jacc Cardiovasc Interv 13, no. 11 (June 8, 2020): 1329–39. https://doi.org/10.1016/j.jcin.2020.03.011.
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    • Chau, Katherine H., Pamela S. Douglas, Philippe Pibarot, Rebecca T. Hahn, Omar K. Khalique, Wael A. Jaber, Paul Cremer, et al. “Regression of Left Ventricular Mass After Transcatheter Aortic Valve Replacement: The PARTNER Trials and Registries.” J Am Coll Cardiol 75, no. 19 (May 19, 2020): 2446–58. https://doi.org/10.1016/j.jacc.2020.03.042.
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    • Daubert, Melissa A., Jennifer A. White, Hussein R. Al-Khalidi, Eric J. Velazquez, Sunil V. Rao, Anna Lisa Crowley, Uwe Zeymer, et al. “Cardiac remodeling after large ST-elevation myocardial infarction in the current therapeutic era.” Am Heart J 223 (May 2020): 87–97. https://doi.org/10.1016/j.ahj.2020.02.017.
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    • Daubert, Melissa A., Joseph Sivak, Allison Dunning, Pamela S. Douglas, Brian Coyne, Tracy Y. Wang, Daniel B. Mark, and Eric J. Velazquez. “Implications of Abnormal Exercise Electrocardiography With Normal Stress Echocardiography.” Jama Intern Med 180, no. 4 (April 1, 2020): 494–502. https://doi.org/10.1001/jamainternmed.2019.6958.
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    • Daubert, Melissa A. “Diastolic Function in Heart Failure With Reduced Ejection Fraction: The Overlooked Prognosticator?” Jacc Heart Fail 7, no. 9 (September 2019): 818–20. https://doi.org/10.1016/j.jchf.2019.06.005.
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    • Daubert, Melissa A., and Pamela S. Douglas. “Primary Prevention of Heart Failure in Women.” Jacc Heart Fail 7, no. 3 (March 2019): 181–91. https://doi.org/10.1016/j.jchf.2019.01.011.
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    • Daubert, Melissa A., Kirkwood Adams, Eric Yow, Huiman X. Barnhart, Pamela S. Douglas, Susan Rimmer, Casey Norris, et al. “NT-proBNP Goal Achievement Is Associated With Significant Reverse Remodeling and Improved Clinical Outcomes in HFrEF.” Jacc Heart Fail 7, no. 2 (February 2019): 158–68. https://doi.org/10.1016/j.jchf.2018.10.014.
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    • Pagidipati, Neha J., Adrian Coles, Kshipra Hemal, Kerry L. Lee, Rowena J. Dolor, Patricia A. Pellikka, Daniel B. Mark, et al. “Sex differences in management and outcomes of patients with stable symptoms suggestive of coronary artery disease: Insights from the PROMISE trial.” Am Heart J 208 (February 2019): 28–36. https://doi.org/10.1016/j.ahj.2018.11.002.
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    • Artzner, Christoph, Melissa Daubert, Wendy Ehieli, David Kong, Joseph Mammarappallil, Konstantin Nikolaou, Daniel T. Boll, and Lynne Koweek. “Impact of computed tomography (CT)-derived fractional flow reserve on reader confidence for interpretation of coronary CT angiography.” Eur J Radiol 108 (November 2018): 242–48. https://doi.org/10.1016/j.ejrad.2018.09.035.
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    • Douglas, Pamela S., and Melissa A. Daubert. “A Tale of 2 Tests.” Jacc Cardiovasc Imaging 11, no. 9 (September 2018): 1298–1300. https://doi.org/10.1016/j.jcmg.2018.04.016.
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    • Daubert, Melissa A., David J. Whellan, Holger Woehrle, Gudaye Tasissa, Kevin J. Anstrom, JoAnn Lindenfeld, Adam Benjafield, et al. “Treatment of sleep-disordered breathing in heart failure impacts cardiac remodeling: Insights from the CAT-HF Trial.” Am Heart J 201 (July 2018): 40–48. https://doi.org/10.1016/j.ahj.2018.03.026.
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    • Bhavnani, Sanjeev P., Srikanth Sola, David Adams, Ashwin Venkateshvaran, P. K. Dash, Partho P. Sengupta, and Partho P. ASEF-VALUES Investigators. “A Randomized Trial of Pocket-Echocardiography Integrated Mobile Health Device Assessments in Modern Structural Heart Disease Clinics.” Jacc Cardiovasc Imaging 11, no. 4 (April 2018): 546–57. https://doi.org/10.1016/j.jcmg.2017.06.019.
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    • Daubert, Melissa A., Eric Yow, Gary Dunn, Sotir Marchev, Huiman Barnhart, Pamela S. Douglas, Christopher O’Connor, Sidney Goldstein, James E. Udelson, and Hani N. Sabbah. “Novel Mitochondria-Targeting Peptide in Heart Failure Treatment: A Randomized, Placebo-Controlled Trial of Elamipretide.” Circ Heart Fail 10, no. 12 (December 2017). https://doi.org/10.1161/CIRCHEARTFAILURE.117.004389.
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    • Daubert, Melissa A., Neil J. Weissman, Rebecca T. Hahn, Philippe Pibarot, Rupa Parvataneni, Michael J. Mack, Lars G. Svensson, et al. “Long-Term Valve Performance of TAVR and SAVR: A Report From the PARTNER I Trial.” Jacc Cardiovasc Imaging, December 8, 2016. https://doi.org/10.1016/j.jcmg.2016.11.004.
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    • Barnhart, Huiman X., Eric Yow, Anna Lisa Crowley, Melissa A. Daubert, Dawn Rabineau, Robert Bigelow, Michael Pencina, and Pamela S. Douglas. “Choice of agreement indices for assessing and improving measurement reproducibility in a core laboratory setting.” Stat Methods Med Res 25, no. 6 (December 2016): 2939–58. https://doi.org/10.1177/0962280214534651.
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    • Crowley, Anna Lisa, Eric Yow, Huiman X. Barnhart, Melissa A. Daubert, Robert Bigelow, Daniel C. Sullivan, Michael Pencina, and Pamela S. Douglas. “Critical Review of Current Approaches for Echocardiographic Reproducibility and Reliability Assessment in Clinical Research.” J Am Soc Echocardiogr 29, no. 12 (December 2016): 1144-1154.e7. https://doi.org/10.1016/j.echo.2016.08.006.
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    • Pagidipati, Neha J., Kshipra Hemal, Adrian Coles, Daniel B. Mark, Rowena J. Dolor, Patricia A. Pellikka, Udo Hoffmann, et al. “Sex Differences in Functional and CT Angiography Testing in Patients With Suspected Coronary Artery Disease.” J Am Coll Cardiol 67, no. 22 (June 7, 2016): 2607–16. https://doi.org/10.1016/j.jacc.2016.03.523.
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    • Hemal, Kshipra, Neha J. Pagidipati, Adrian Coles, Rowena J. Dolor, Daniel B. Mark, Patricia A. Pellikka, Udo Hoffmann, et al. “Sex Differences in Demographics, Risk Factors, Presentation, and Noninvasive Testing in Stable Outpatients With Suspected Coronary Artery Disease: Insights From the PROMISE Trial.” Jacc Cardiovasc Imaging 9, no. 4 (April 2016): 337–46. https://doi.org/10.1016/j.jcmg.2016.02.001.
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    • Daubert, Melissa A., Joseph Massaro, Lawrence Liao, Ashish Pershad, Suresh Mulukutla, Erik Magnus Ohman, Jeffrey Popma, William W. O’Neill, and Pamela S. Douglas. “High-risk percutaneous coronary intervention is associated with reverse left ventricular remodeling and improved outcomes in patients with coronary artery disease and reduced ejection fraction.” Am Heart J 170, no. 3 (September 2015): 550–58. https://doi.org/10.1016/j.ahj.2015.06.013.
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    • Daubert, Melissa A., Eric Yow, Huiman X. Barnhart, Dawn Rabineau, Anna Lisa Crowley, and Pamela S. Douglas. “Quality Improvement Implementation: Improving Reproducibility in the Echocardiography Laboratory.” J Am Soc Echocardiogr 28, no. 8 (August 2015): 959–68. https://doi.org/10.1016/j.echo.2015.03.004.
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    • Douglas, Pamela S., and Melissa A. Daubert. “Diagnostic accuracy of noninvasive testing: necessary but insufficient.” Circ Cardiovasc Imaging 8, no. 3 (March 2015). https://doi.org/10.1161/CIRCIMAGING.115.003138.
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    • Daubert, Melissa A., Joseph Massaro, Jeffrey Popma, Ashish Pershad, Suresh Mulukutla, Magnus Ohman, William O’Neill, and Pamela Douglas. “HIGH-RISK PERCUTANEOUS CORONARY INTERVENTION RESULTS IN SUBSTANTIAL REVERSE REMODELING OF THE LEFT VENTRICLE IN ISCHEMIC CARDIOMYOPATHY.” Journal of the American College of Cardiology 63, no. 12 (April 2014): A1572–A1572. https://doi.org/10.1016/s0735-1097(14)61575-8.
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    • Abramowicz, A. J., M. A. Daubert, V. Malhotra, S. Ferraro, J. Ring, R. Goldenberg, M. Kam, et al. “Computer-aided analysis of 64-slice coronary computed tomography angiography: A comparison with manual interpretation.” Heart International 8, no. 1 (January 1, 2013): 4–8. https://doi.org/10.4081/hi.2013.e2.
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    • Daubert, Melissa A., Huiman X. Barnhart, Eric Yow, Dawn Rabineau, and Pamela S. Douglas. “A Practical Approach to Quality Assurance Implementation in Clinical Echocardiographic Laboratories.” Circulation 126, no. 21 (November 20, 2012).
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    • Singer, Adam J., Anna Domingo, Henry C. Thode, Melissa Daubert, Alan F. Vainrib, Summer Ferraro, Amee Minton, Annie Poon, Mark C. Henry, and Michael Poon. “Utilization of coronary computed tomography angiography for exclusion of coronary artery disease in ED patients with low- to intermediate-risk chest pain: a 1-year experience.” Am J Emerg Med 30, no. 9 (November 2012): 1706–11. https://doi.org/10.1016/j.ajem.2012.01.025.
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    • Hellinger, Jeffrey C., Melissa Daubert, Edward Y. Lee, and Monica Epelman. “Congenital thoracic vascular anomalies: evaluation with state-of-the-art MR imaging and MDCT.” Radiol Clin North Am 49, no. 5 (September 2011): 969–96. https://doi.org/10.1016/j.rcl.2011.06.013.
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    • Daubert, Melissa A., Kathleen Stergiopoulos, and David L. Brown. “A caravanning cardiomyopathy.” Am J Med 124, no. 9 (September 2011): 824–26. https://doi.org/10.1016/j.amjmed.2011.02.004.
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    • Daubert, M. A., A. Jeremias, and D. L. Brown. “Diagnosis of Acute Myocardial Infarction,” December 1, 2010, 97–105. https://doi.org/10.1016/B978-1-4160-3773-6.10010-2.
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    • Daubert, Melissa A., and Allen Jeremias. “The utility of troponin measurement to detect myocardial infarction: review of the current findings.” Vasc Health Risk Manag 6 (September 7, 2010): 691–99. https://doi.org/10.2147/vhrm.s5306.
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  • Book Sections

    • Daubert, M. A., S. Kort, K. Axsom, and M. Saric. “Introduction and Etiology of Pulmonic Regurgitation.” In ASE’s Comprehensive Echocardiography, 529–35, 2015. https://doi.org/10.1016/B978-0-323-26011-4.09959-9.
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    • Daubert, M. A., A. Jeremias, and D. L. Brown. “Diagnosis of acute myocardial infarction.” In Cardiac Intensive Care: Expert Consult, 97–105, 2010. https://doi.org/10.1016/B978-1-4160-3773-6/10010-2.
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  • Conference Papers

    • Williams, Adam R., Joseph Nellis, Zachary Wegermann, Sharon McCartney, Mihai V. Podgoreanu, Sachin Mehta, Kyha D. Williams, et al. “Abstract P1017: Tissue Engineered Human Acellular Blood Vessels For Coronary Artery Bypass Grafting.” In Circulation Research, Vol. 131. Ovid Technologies (Wolters Kluwer Health), 2022. https://doi.org/10.1161/res.131.suppl_1.p1017.
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    • Cauwenberghs, N., M. A. Daubert, M. Salerno, F. Haddad, T. Kuznetsova, and P. S. Douglas. “Echocardiographic diversity associated with exercise capacity in heart failure precursor stage B: the Project Baseline Health Study.” In European Heart Journal, 43:924–924, 2022.
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    • Williams, Adam R., Joseph Nellis, Sharon McCartney, Sachin Mehta, Mihai V. Podgoreanu, Melissa A. Daubert, Robert Kirkton, et al. “Six Month Patency of Bioengineered Human Acellular Vessels in a Primate Model of Coronary Artery Bypass Grafting.” In Circulation, Vol. 146, 2022.
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    • Daubert, Melissa A., Amanda Stebbins, Rachel Urrutia, Karen Chiswell, Matthew Loop, Ceshae Harding, Thomas Price, Paula Miller, and Tracy Wang. “POSTPARTUM BLOOD PRESSURE SCREENING IN WOMEN WITH HYPERTENSIVE DISORDERS OF PREGNANCY.” In Journal of the American College of Cardiology, 77:3399–3399, 2021.
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    • Crowley, Anna Lisa, Eric Yow, Dawn Rabineau, Casey Norris, Jennifer White, Melissa A. Daubert, Eric J. Velazquez, et al. “The Impact of a Rigorous Quality Program on 3D Echocardiography Data Quality in an International Multisite Randomized Trial.” In Jacc Cardiovasc Imaging, 11:1918–20, 2018. https://doi.org/10.1016/j.jcmg.2018.05.024.
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    • Pristera, Nicole, Eric Yow, Pamela S. Douglas, Huiman X. Barnhart, Eric Leifer, Lawton Cooper, Patrice Desvigne-Nickens, et al. “Predictors and Outcomes of Reverse Remodeling in Heart Failure With Reduced Ejection Fraction.” In Circulation, Vol. 138, 2018.
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    • Daubert, Melissa A., Eric Yow, Huiman Barnhart, Pamela S. Douglas, Susan Rimmer, Casey Norris, Lawton Copper, et al. “Biomarker-Guided Heart Failure Therapy Results in Significant Reverse Left Ventricular Remodeling Among Patients Achieving NT-proBNP Goal: Insights From the GUIDE-IT Trial.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.
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    • Daubert, Melissa A., Eric Yow, Gary Dunn, Huiman Barnhart, Pamela Douglas, James Udelson, Christopher O’Connor, Sidney Goldstein, and Hani Sabbah. “EFFECTS OF A NOVEL TETRAPEPTIDE IN HEART FAILURE WITH REDUCED EJECTION FRACTION (HFREF): A PHASE I RANDOMIZED, PLACEBO-CONTROLLED TRIAL OF ELAMIPRETIDE.” In Journal of the American College of Cardiology, 67:1283–1283. Elsevier BV, 2016. https://doi.org/10.1016/s0735-1097(16)31284-0.
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    • Daubert, Melissa A., Philippe Pibarot, Rebecca Hahn, Neil Weissman, William Stewart, Justina Wu, Sammy Elmariah, et al. “TRANSCATHETER AORTIC VALVE REPLACEMENT RESULTS IN SIGNIFICANT REVERSE REMODELING IN PATIENTS WITH LEFT VENTRICULAR DILATION: A REPORT FROM THE PARTNER I TRIAL.” In Journal of the American College of Cardiology, 65:A1711–A1711. Elsevier BV, 2015. https://doi.org/10.1016/s0735-1097(15)61711-9.
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