Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow in Nephrology, Medicine, Tufts University 1985 - 1989
  • Medical Resident, Medicine, University of Virginia 1982 - 1985
  • M.D., University of North Carolina at Chapel Hill 1982
• 

  Duke Appointment History

  • Associate Professor of Medicine, Medicine, Nephrology, Medicine 2001 - 2007
  • Instructor, Temporary in the Department of Medicine, Medicine, Nephrology, Medicine 2000
• Research
• 

  Selected Grants

  • Gene-Environment Collaboration in Autoimmune Disease awarded by National Institutes of Health 2017 - 2022
  • Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2022
  • Dual humanization to model gene-environment interactions in ANCA vasculitis 2017 - 2018
  • Duke O'Brien Center for Kidney Research awarded by National Institutes of Health 2012 - 2018
  • The role of dendritic cell-mediated T cell activation in hypertension awarded by National Institutes of Health 2017
  • Training Program in Inflammatory and Immunological Diseases awarded by National Institutes of Health 1980 - 2017
  • Mechanism of Silica-induced Autoimmunity awarded by National Institutes of Health 2014 - 2017
  • Novel Receptor-Ligand Interactions in Glomerulonephritis awarded by National Institutes of Health 2011 - 2017
  • Proximal Determinants of Nephritogenic Autoimmunity awarded by National Institutes of Health 1995 - 2012
  • IPA - Ting Yu awarded by Veterans Administration Medical Center 2010
  • IPA - Melissa Weston awarded by Veterans Administration Medical Center 2009
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Sadun, Rebecca E., and Mary H. Foster. “Déjà Vu But New: Using T Cells to Deplete B Cells to Treat Lupus..” Am J Kidney Dis, May 30, 2019. https://doi.org/10.1053/j.ajkd.2019.04.009.
       Full Text  Link to Item
    • Foster, Mary Helen, and Jeffrey Robinson Ord. “Emerging immunotherapies for autoimmune kidney disease..” Hum Vaccin Immunother 15, no. 4 (2019): 876–90. https://doi.org/10.1080/21645515.2018.1555569.
       Full Text  Link to Item
    • Clark, Amy G., Elizabeth S. Buckley, and Mary H. Foster. “Altered toll-like receptor responsiveness underlies a dominant heritable defect in B cell tolerance in autoimmune New Zealand Black mice..” Eur J Immunol 48, no. 3 (March 2018): 492–97. https://doi.org/10.1002/eji.201747287.
       Full Text  Link to Item
    • Clark, Amy G., Inge M. Worni-Schudel, Francesca M. Korte, and Mary H. Foster. “A murine Ig light chain transgene reveals IGKV3 gene contributions to anti-collagen types IV and II specificities..” Mol Immunol 91 (November 2017): 49–56. https://doi.org/10.1016/j.molimm.2017.08.015.
       Full Text  Link to Item
    • Foster, Mary H. “Basement membranes and autoimmune diseases..” Matrix Biol 57–58 (January 2017): 149–68. https://doi.org/10.1016/j.matbio.2016.07.008.
       Full Text  Link to Item
    • Foster, Mary H. “Optimizing the translational value of animal models of glomerulonephritis: insights from recent murine prototypes..” Am J Physiol Renal Physiol 311, no. 3 (September 1, 2016): F487–95. https://doi.org/10.1152/ajprenal.00275.2016.
       Full Text  Link to Item
    • Foster, Mary H., Elizabeth S. Buckley, Benny J. Chen, Kwan-Ki Hwang, and Amy G. Clark. “Uncommon structural motifs dominate the antigen binding site in human autoantibodies reactive with basement membrane collagen..” Mol Immunol 76 (August 2016): 123–33. https://doi.org/10.1016/j.molimm.2016.07.004.
       Full Text  Link to Item
    • Worni-Schudel, Inge M., Amy G. Clark, Tiffany Chien, Kwan-Ki Hwang, Benny J. Chen, and Mary H. Foster. “Recovery of a human natural antibody against the noncollagenous-1 domain of type IV collagen using humanized models..” J Transl Med 13 (June 6, 2015). https://doi.org/10.1186/s12967-015-0539-4.
       Full Text  Link to Item
    • Clark, Amy G., Melissa L. Weston, and Mary H. Foster. “Lack of galectin-1 or galectin-3 alters B cell deletion and anergy in an autoantibody transgene model..” Glycobiology 23, no. 7 (July 2013): 893–903. https://doi.org/10.1093/glycob/cwt026.
       Full Text  Link to Item
    • Clark, Amy G., Qihua Fan, Graham F. Brady, Katherine M. Mackin, Evan D. Coffman, Melissa L. Weston, and Mary H. Foster. “Regulation of basement membrane-reactive B cells in BXSB, (NZBxNZW)F1, NZB, and MRL/lpr lupus mice..” Autoimmunity 46, no. 3 (May 2013): 188–204. https://doi.org/10.3109/08916934.2012.746671.
       Full Text  Link to Item
    • Clark, Amy G., Katherine M. Mackin, and Mary H. Foster. “Genetic elimination of α3(IV) collagen fails to rescue anti-collagen B cells..” Immunol Lett 141, no. 1 (December 30, 2011): 134–39. https://doi.org/10.1016/j.imlet.2011.09.004.
       Full Text  Link to Item
    • Crowley, Steven D., Matthew P. Vasievich, Phillip Ruiz, Samantha K. Gould, Kelly K. Parsons, A Kathy Pazmino, Carie Facemire, et al. “Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis..” J Clin Invest 119, no. 4 (April 2009): 943–53. https://doi.org/10.1172/JCI34862.
       Full Text  Link to Item
    • Kelley, V. R., L. Morel, and M. H. Foster. “Systemic lupus erythematosus and the kidney,” December 1, 2008, 509–30. https://doi.org/10.1016/B978-1-4160-0252-9.50033-1.
       Full Text
    • Zhang, Ying, Susan C. Su, Douglas B. Hecox, Graham F. Brady, Katherine M. Mackin, Amy G. Clark, and Mary H. Foster. “Central tolerance regulates B cells reactive with Goodpasture antigen alpha3(IV)NC1 collagen..” J Immunol 181, no. 9 (November 1, 2008): 6092–6100. https://doi.org/10.4049/jimmunol.181.9.6092.
       Full Text  Link to Item
    • Foster, Mary H. “Novel targets for immunotherapy in glomerulonephritis..” Biologics 2, no. 3 (September 2008): 531–45.
       Link to Item
    • Clark, Amy G., Katherine M. Mackin, and Mary H. Foster. “Tracking Differential Gene Expression in MRL/MpJ Versus C57BL/6 Anergic B Cells: Molecular Markers of Autoimmunity..” Biomark Insights 3 (June 10, 2008): 335–50.
       Link to Item
    • Clark, Amy G., Sihong Chen, Hao Zhang, Graham F. Brady, Erica K. Ungewitter, Joanna K. Bradley, Faustina N. Sackey, and Mary H. Foster. “Multifunctional regulators of cell growth are differentially expressed in anergic murine B cells..” Mol Immunol 44, no. 6 (February 2007): 1274–85. https://doi.org/10.1016/j.molimm.2006.06.001.
       Full Text  Link to Item
    • Foster, Mary H. “T cells and B cells in lupus nephritis..” Semin Nephrol 27, no. 1 (January 2007): 47–58. https://doi.org/10.1016/j.semnephrol.2006.09.007.
       Full Text  Link to Item
    • Foster, Mary H., Ying Zhang, and Amy G. Clark. “Deconstructing B cell tolerance to basement membranes..” Arch Immunol Ther Exp (Warsz) 54, no. 4 (July 2006): 227–37. https://doi.org/10.1007/s00005-006-0027-x.
       Full Text  Link to Item
    • Amital, Howard, Michal Heilweil, Rina Ulmansky, Fanny Szafer, Ruth Bar-Tana, Laurence Morel, Mary H. Foster, et al. “Treatment with a laminin-derived peptide suppresses lupus nephritis..” J Immunol 175, no. 8 (October 15, 2005): 5516–23. https://doi.org/10.4049/jimmunol.175.8.5516.
       Full Text  Link to Item
    • Brady, G. F., K. L. Congdon, A. G. Clark, F. N. A. Sackey, E. H. Rudolph, M. Z. Radic, and M. H. Foster. “κ Editing Rescues Autoreactive B Cells Destined for Deletion in Mice Transgenic for a Dual Specific Anti-Laminin Ig.” Journal of Immunology 172, no. 9 (May 1, 2004): 5313–21.
    • Brady, Graham F., Kendra L. Congdon, Amy G. Clark, Faustina N. A. Sackey, Earl H. Rudolph, Marko Z. Radic, and Mary H. Foster. “Kappa editing rescues autoreactive B cells destined for deletion in mice transgenic for a dual specific anti-laminin Ig..” J Immunol 172, no. 9 (May 1, 2004): 5313–21. https://doi.org/10.4049/jimmunol.172.9.5313.
       Full Text  Link to Item
    • Foster, Mary Helen. “Taking HAART in HIVAN: will protease inhibitor sparing regimens alter renal outcome?.” Kidney Int 65, no. 3 (March 2004): 1105–6. https://doi.org/10.1111/j.1523-1755.2004.00527.x.
       Full Text  Link to Item
    • Clark, A. G., G. F. Brady, F. N. Sackey, and M. H. Foster. “Defining immune tolerance through gene expression profiling..” Journal of the American Society of Nephrology 13 (September 1, 2002): 348A-348A.
       Link to Item
    • Congdon, K. C., G. F. Brady, and M. H. Foster. “Complex tolerance phenotypes induced by lupus autoantigens..” Journal of the American Society of Nephrology 13 (September 1, 2002): 171A-171A.
       Link to Item
    • Sackey, F. N., and M. H. Foster. “Dissecting the biochemical basis of tolerance: Role for differential activation of MAPKs, NF-kB and NFAT..” Journal of the American Society of Nephrology 13 (September 1, 2002): 346A-346A.
       Link to Item
    • Rudolph, Earl H., Kendra L. Congdon, Faustina N. A. Sackey, Muriel M. Fitzsimons, and Mary H. Foster. “Humoral autoimmunity to basement membrane antigens is regulated in C57BL/6 and MRL/MpJ mice transgenic for anti-laminin Ig receptors..” J Immunol 168, no. 11 (June 1, 2002): 5943–53. https://doi.org/10.4049/jimmunol.168.11.5943.
       Full Text  Link to Item
    • Cooperstone, B. G., M. M. Rahman, E. H. Rudolph, and M. H. Foster. “In vitro and in vivo expression of a nephritogenic Ig heavy chain determinant: pathogenic autoreactivity requires permissive light chains..” Immunol Cell Biol 79, no. 3 (June 2001): 222–30. https://doi.org/10.1046/j.1440-1711.2001.01001.x.
       Full Text  Link to Item
    • Cohen, D. L., J. Post, A. A. Ferroggiaro, J. Perrone, and M. H. Foster. “Chronic salicylism resulting in noncardiogenic pulmonary edema requiring hemodialysis..” Am J Kidney Dis 36, no. 3 (September 2000). https://doi.org/10.1053/ajkd.2000.16223.
       Full Text  Link to Item
    • Fitzsimons, M. M., H. Chen, and M. H. Foster. “Diverse endogenous light chains contribute to basement membrane reactivity in nonautoimmune mice transgenic for an anti-laminin Ig heavy chain..” Immunogenetics 51, no. 1 (January 2000): 20–29.
       Link to Item
    • Kieber-Emmons, T., C. Lin, M. H. Foster, and T. R. Kleyman. “Antiidiotypic antibody recognizes an amiloride binding domain within the alpha subunit of the epithelial Na+ channel..” J Biol Chem 274, no. 14 (April 2, 1999): 9648–55. https://doi.org/10.1074/jbc.274.14.9648.
       Full Text  Link to Item
    • Foster, M. H., and V. R. Kelley. “Lupus nephritis: update on pathogenesis and disease mechanisms..” Semin Nephrol 19, no. 2 (March 1999): 173–81.
       Link to Item
    • Foster, M. H. “Relevance of systemic lupus erythematosus nephritis animal models to human disease..” Semin Nephrol 19, no. 1 (January 1999): 12–24.
       Link to Item
    • Rosas, S. E., J. E. Tomaszewski, H. I. Feldman, and M. H. Foster. “Membranoproliferative glomerulonephritis type I, mixed cryoglobulinemia and lymphoma in the absence of hepatitis C infection..” Am J Nephrol 19, no. 5 (1999): 599–604. https://doi.org/10.1159/000013527.
       Full Text  Link to Item
    • Foster, M. H., B. G. Cooperstone, and H. Chen. “Anti-idiotypic monoclonal Ig specific for an anti-laminin Ig heavy chain transgene variable region..” Hybridoma 17, no. 4 (August 1998): 323–29. https://doi.org/10.1089/hyb.1998.17.323.
       Full Text  Link to Item
    • Foster, M. H., and M. M. Fitzsimons. “Lupus-like nephrotropic autoantibodies in non-autoimmune mice harboring an anti-basement membrane/anti-DNA Ig heavy chain transgene..” Mol Immunol 35, no. 2 (February 1998): 83–94.
       Link to Item
    • Fitzsimons, M. M., and M. H. Foster. “The nephritogenic immune response..” Curr Opin Nephrol Hypertens 6, no. 3 (May 1997): 267–75.
       Link to Item
    • Madaio, M. P., K. Yanase, M. H. Foster, R. M. Smith, T. K. Emmons, M. Fabbi, A. Puccetti, and L. Jarett. “Nuclear localization of autoantibodies. Novel insights into protein translocation and cellular function..” Ann N Y Acad Sci 815 (April 5, 1997): 263–66. https://doi.org/10.1111/j.1749-6632.1997.tb52068.x.
       Full Text  Link to Item
    • Foster, M. H., Q. Liu, H. Chen, D. Nemazee, and B. G. Cooperstone. “Anti-laminin reactivity and glomerular immune deposition by in vitro recombinant antibodies..” Autoimmunity 26, no. 4 (1997): 231–43.
       Link to Item
    • Vargas, M. T., K. Gustilo, D. M. D’Andrea, R. Kalluri, M. H. Foster, and M. P. Madaio. “Structural features of nephritogenic lupus autoantibodies..” Methods 11, no. 1 (January 1997): 62–69. https://doi.org/10.1006/meth.1996.0388.
       Full Text  Link to Item
    • D’Andrea, D. M., B. Coupaye-Gerard, T. R. Kleyman, M. H. Foster, and M. P. Madaio. “Lupus autoantibodies interact directly with distinct glomerular and vascular cell surface antigens..” Kidney Int 49, no. 5 (May 1996): 1214–21.
       Link to Item
    • Yanase, K., R. M. Smith, B. Cĭzman, M. H. Foster, L. D. Peachey, L. Jarett, and M. P. Madaio. “A subgroup of murine monoclonal anti-deoxyribonucleic acid antibodies traverse the cytoplasm and enter the nucleus in a time-and temperature- dependent manner..” Lab Invest 71, no. 1 (July 1994): 52–60.
       Link to Item
    • Lin, C., T. Kieber-Emmons, A. P. Villalobos, M. H. Foster, C. Wahlgren, and T. R. Kleyman. “Topology of an amiloride-binding protein..” J Biol Chem 269, no. 4 (January 28, 1994): 2805–13.
       Link to Item
    • Foster, M. H., T. Kieber-Emmons, M. Ohliger, and M. P. Madaio. “Molecular and structural analysis of nuclear localizing anti-DNA lupus antibodies..” Immunol Res 13, no. 2–3 (1994): 186–206.
       Link to Item
    • Kieber-Emmons, T., M. H. Foster, W. V. Williams, and M. P. Madaio. “Structural properties of a subset of nephritogenic anti-DNA antibodies..” Immunol Res 13, no. 2–3 (1994): 172–85.
       Link to Item
    • Foster, M. H., B. Cizman, and M. P. Madaio. “Nephritogenic autoantibodies in systemic lupus erythematosus: immunochemical properties, mechanisms of immune deposition, and genetic origins..” Lab Invest 69, no. 5 (November 1993): 494–507.
       Link to Item
    • Foster, M. H., J. Sabbaga, S. R. Line, K. S. Thompson, K. J. Barrett, and M. P. Madaio. “Molecular analysis of spontaneous nephrotropic anti-laminin antibodies in an autoimmune MRL-lpr/lpr mouse..” J Immunol 151, no. 2 (July 15, 1993): 814–24.
       Link to Item
    • Katz, M. S., M. H. Foster, and M. P. Madaio. “Independently derived murine glomerular immune deposit-forming anti-DNA antibodies are encoded by near-identical VH gene sequences..” J Clin Invest 91, no. 2 (February 1993): 402–8. https://doi.org/10.1172/JCI116214.
       Full Text  Link to Item
    • Vlahakos, D. V., M. H. Foster, S. Adams, M. Katz, A. A. Ucci, K. J. Barrett, S. K. Datta, and M. P. Madaio. “Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites..” Kidney Int 41, no. 6 (June 1992): 1690–1700.
       Link to Item
    • Foster, M. H., M. P. Madaio, and K. J. Barrett. “Variable region sequence analysis of anti-DNA antibodies: evidence for a family of closely related germ-line VH genes encoding lupus autoantibodies..” Dna Cell Biol 11, no. 3 (April 1992): 175–82. https://doi.org/10.1089/dna.1992.11.175.
       Full Text  Link to Item
    • Vlahakos, D., M. H. Foster, A. A. Ucci, K. J. Barrett, S. K. Datta, and M. P. Madaio. “Murine monoclonal anti-DNA antibodies penetrate cells, bind to nuclei, and induce glomerular proliferation and proteinuria in vivo..” J Am Soc Nephrol 2, no. 8 (February 1992): 1345–54.
       Link to Item
    • Foster, M. H., M. MacDonald, K. J. Barrett, and M. P. Madaio. “VH gene analysis of spontaneously activated B cells in adult MRL-lpr/lpr mice. J558 bias is not limited to classic lupus autoantibodies..” J Immunol 147, no. 5 (September 1, 1991): 1504–11.
       Link to Item
    • Foster, M. H., G. R. Sant, J. F. Donohoe, and J. T. Harrington. “Prolonged survival with a remnant kidney..” Am J Kidney Dis 17, no. 3 (March 1991): 261–65.
       Link to Item

  • Conference Papers

    • Ord, Jeffrey R., Amy G. Clark, and Mary H. Foster. “Shared Genetic Origins Among Anti-Proteinase 3 and Anti-Glomerular Basement Membrane Double-Positive Human Autoantibodies.” In Arthritis & Rheumatology, Vol. 70. WILEY, 2018.
       Link to Item
    • Brady, G. F., G. T. Mixon, A. G. Clark, and M. H. Foster. “Tracking immune tolerance in autoimmune susceptible mice..” In Journal of the American Society of Nephrology, 14:383A-383A. LIPPINCOTT WILLIAMS & WILKINS, 2003.
       Link to Item
    • Foster, M. H., G. F. Brady, E. K. Lobenhofer, and A. G. Clark. “Unique gene expression patterns in MRL and B6 tolerant B cells revealed by microarray.” In Faseb Journal, 17:C180–C180. FEDERATION AMER SOC EXP BIOL, 2003.
       Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.