Overview
Pediatric and adult clinical pharmacology and clinical trials.
Current Appointments & Affiliations
Kiser-Arena Distinguished Professor
·
2020 - Present
Pediatrics, Infectious Diseases,
Pediatrics
Professor of Pediatrics
·
2017 - Present
Pediatrics, Infectious Diseases,
Pediatrics
Member in the Duke Clinical Research Institute
·
2007 - Present
Duke Clinical Research Institute,
Institutes and Centers
Recent Publications
Population Pharmacokinetics and Exposure-Safety Analysis of Furosemide in Preterm Infants.
Journal Article J Clin Pharmacol · April 2026 Furosemide is the most commonly used diuretic in preterm infants despite an incompletely understood relationship between dosing, exposure, and safety within this population. The goals of this study were to characterize furosemide population pharmacokinetic ... Full text Link to item CiteEvaluating the duration of post-discontinuation therapeutic ampicillin exposures in preterm infants.
Journal Article J Perinatol · March 13, 2026 OBJECTIVE: Determine if preterm infants have prolonged therapeutic post-discontinuation antibiotic exposures (PDAE) following empiric ampicillin. STUDY DESIGN: Prospective study of 27 infants ≤7 days and <37 weeks gestational age (GA) receiving ampicillin ... Full text Link to item CitePopulation Pharmacokinetics to Support Intravenous and Enteral Methadone Dosing in Children.
Journal Article J Clin Pharmacol · January 2026 Methadone is used in hospitalized children to treat pain and iatrogenic opiate withdrawal. Optimal pediatric dosing for both enteral and intravenous methadone is unknown. We conducted two prospective, multi-center, open-label studies to characterize the ph ... Full text Link to item CiteRecent Grants
INNOVATE (Integrated National Network for Obstetric and Pediatric AdVAncement in Therapeutic Education)
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2026 - 2031iPediHeart: Interdisciplinary Research Training Program for Pediatric Heart Disease
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2025 - 20302/3 CTSA K12 Program at Duke University
ResearchMentor · Awarded by National Institutes of Health · 2025 - 2030View All Grants
Education
University of North Carolina, Chapel Hill, School of Medicine ·
2012
Ph.D.
Universidad Central de Venezuela (Venezuela) ·
2001
M.D.