Michael Bradley Datto | Scholars@Duke

Michael Bradley Datto
Associate Professor of Pathology

Dr. Datto is an AP/CP/MGP board certified pathologist who specializes in molecular pathology. He is the Medical Director for Duke University Health System Clinical Laboratories. He also directs the Duke University Health System Clinical Molecular Diagnostics Laboratory. In these roles, he is responsible for maintaining the standards of the College of American Pathologists and CLIA/CMS within all Clinical Laboratories at Duke. Specifically, Dr. Datto oversees clinical testing and reporting, develops quality management systems and proficiency testing programs, provides consultation with ordering physicians, ensures educational programs, develops strategic plans that are in line with the needs of our patient population, physicians and health system leadership, coordinates research and development, ensures adequate and appropriately trained personnel, and provides profession interpretation for molecular diagnostic testing including the wide range of PCR, quantitative PCR, sequencing and FISH based tests for inherited genetic diseases, hematologic malignancies, solid tumors and infectious diseases.

Dr. Datto also has an independent research program developing and evaluating multigene assays to determine cancer patient specific prognoses in the context of breast, ovary and colon cancer. The ultimate goal of this work is to produce improved molecular diagnostic assays that incorporate genome wide prognostic and diagnostic molecular profiling into the clinical laboratories for routine patient care. This involves the study of factors that affect the precision and accuracy of array-based and next-generation sequencing based approaches, as well as the discovery of novel diagnostic molecular makers. Finally, Dr. Datto has a strong research interest in resident and medical student education, specifically the development of web-base community tools for anatomic and clinical pathology education.

Current Appointments & Affiliations

Associate Professor of Pathology, Pathology, Clinical Science Departments 2012
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1995

Contact Information

Dept Of Pathology, Durham, NC 27710
Duke Box 3712, Durham, NC 27710
michael.datto@duke.edu (919) 684-6965
DukeMolecular
Pathologypics

Background
Education, Training, & Certifications
- Resident, Pathology, Duke University 2000 - 2004
- Post-Doctoral Fellow, Pharmacology, Duke University 1999 - 2000
- M.D., Duke University 1999
- Ph.D., Duke University 1998
- B.A., Johns Hopkins University 1991
Duke Appointment History
- Assistant Professor of Pathology, Pathology, Clinical Science Departments 2004 - 2012
- Instructor, Temporary of Pathology, Pathology, Clinical Science Departments 2004
Research
Selected Grants
- Non Muscle Myosin II Contractility Putatively Regulates Scar Contracture awarded by National Institutes of Health 2008 - 2013
- Programs in Clinical Effectiveness of Cancer Pharmacogenomics awarded by National Institutes of Health 2009 - 2012
- Validating Molecular Signature Risk Models of NSCLC awarded by National Institutes of Health 2006 - 2012
- Intellectual Property Challenges for the Development of Genomic Diagnostics awarded by National Institutes of Health 2009 - 2012
- Gene Targeted Therapy of Brain Tumors awarded by National Institutes of Health 2009 - 2012
- Prospective Validation of Genomic Signatures of Chemosensitivity in NSCLC awarded by National Institutes of Health 2009 - 2010
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Korkut, A, Zaidi, S, Kanchi, RS, Rao, S, Gough, NR, Schultz, A, Li, X, Lorenzi, PL, Berger, AC, Robertson, G, Kwong, LN, Datto, M, Roszik, J, Ling, S, Ravikumar, V, Manyam, G, Rao, A, Shelley, S, Liu, Y, Ju, Z, Hansel, D, de Velasco, G, Pennathur, A, Andersen, JB, O'Rourke, CJ, Ohshiro, K, Jogunoori, W, Nguyen, B-N, Li, S, Osmanbeyoglu, HU, Ajani, JA, Mani, SA, Houseman, A, Wiznerowicz, M, Chen, J, Gu, S, Ma, W, Zhang, J, Tong, P, Cherniack, AD, Deng, C, Resar, L, Cancer Genome Atlas Research Network, , Weinstein, JN, Mishra, L, and Akbani, R. "A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily." Cell Systems 7, no. 4 (October 2018): 422-437.e7. Full Text
  - Jug, RC, Datto, MB, and Jiang, XS. "Molecular testing for indeterminate thyroid nodules: Performance of the Afirma gene expression classifier and ThyroSeq panel." Cancer Cytopathology (April 10, 2018). Full Text
  - Li, MM, Datto, M, Duncavage, EJ, Kulkarni, S, Lindeman, NI, Roy, S, Tsimberidou, AM, Vnencak-Jones, CL, Wolff, DJ, Younes, A, and Nikiforova, MN. "Authors' Reply." The Journal of molecular diagnostics : JMD 20, no. 1 (January 2018): 125-126. (Letter) Full Text
  - Jiang, XS, Harrison, GP, and Datto, MB. "Reply to Young Investigator Challenge: Molecular testing in noninvasive follicular thyroid neoplasm with papillary-like nuclear features." Cancer Cytopathology 125, no. 4 (April 2017): 293-294. (Letter) Full Text
  - Li, MM, Datto, M, Duncavage, EJ, Kulkarni, S, Lindeman, NI, Roy, S, Tsimberidou, AM, Vnencak-Jones, CL, Wolff, DJ, Younes, A, and Nikiforova, MN. "Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer: A Joint Consensus Recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists." The Journal of Molecular Diagnostics : Jmd 19, no. 1 (January 2017): 4-23. (Review) Full Text
  - Jiang, XS, Harrison, GP, and Datto, MB. "Young Investigator Challenge: Molecular testing in noninvasive follicular thyroid neoplasm with papillary-like nuclear features." Cancer Cytopathology 124, no. 12 (December 2016): 893-900. Full Text
  - Tafe, LJ, Datto, MB, Palomaki, GE, Lacbawan, FL, and CAP/ACMG Biochemical and Molecular Genetics Resource Committee, . "Molecular testing for the BRCA1 and BRCA2 Ashkenazi Jewish founder mutations: a report on the College of American Pathologists proficiency testing surveys." Genetics in Medicine : Official Journal of the American College of Medical Genetics 17, no. 1 (January 2015): 58-62. Full Text
  - McCall, CM, Mosier, S, Thiess, M, Debeljak, M, Pallavajjala, A, Beierl, K, Deak, KL, Datto, MB, Gocke, CD, Lin, M-T, and Eshleman, JR. "False positives in multiplex PCR-based next-generation sequencing have unique signatures." The Journal of Molecular Diagnostics : Jmd 16, no. 5 (September 2014): 541-549. Full Text
  - Stevenson, M, Christensen, J, Shoemaker, D, Foster, T, Barry, WT, Tong, BC, Wahidi, M, Shofer, S, Datto, M, Ginsburg, G, Crawford, J, D'Amico, T, and Ready, N. "Tumor acquisition for biomarker research in lung cancer." Cancer investigation 32, no. 6 (July 2014): 291-298. Full Text
  - Haga, SB, Mills, R, Pollak, KI, Rehder, C, Buchanan, AH, Lipkus, IM, Crow, JH, and Datto, M. "Developing patient-friendly genetic and genomic test reports: formats to promote patient engagement and understanding." Genome medicine 6, no. 7 (January 2014): 58-. Full Text
  - Landi, D, Lockhart, E, Miller, SE, Datto, M, Rehder, C, Kanaly, A, and Thornburg, CD. "Report of a young girl with MYH9 mutation and review of the literature." J Pediatr Hematol Oncol 34, no. 7 (October 2012): 538-540. (Review) Full Text Link to Item
  - Kim, MK, Osada, T, Barry, WT, Yang, XY, Freedman, JA, Tsamis, KA, Datto, M, Clary, BM, Clay, T, Morse, MA, Febbo, PG, Lyerly, HK, and Hsu, DS. "Characterization of an oxaliplatin sensitivity predictor in a preclinical murine model of colorectal cancer." Molecular Cancer Therapeutics 11, no. 7 (July 2012): 1500-1509. Full Text
  - Hutchinson, CB, Stoecker, M, Wang, FF, Papalas, J, Sebastian, S, Burchette, J, Datto, M, and Wang, E. "Molecular detection of circulating Sezary cells in patients with mycosis fungoides: could it predict future development of secondary Sezary syndrome? A single-institution experience." Leuk Lymphoma 53, no. 5 (May 2012): 868-877. Full Text Link to Item
  - Kernagis, DN, Hall, AHS, and Datto, MB. "Genes with bimodal expression are robust diagnostic targets that define distinct subtypes of epithelial ovarian cancer with different overall survival." The Journal of Molecular Diagnostics : Jmd 14, no. 3 (May 2012): 214-222. Full Text
  - Lanasa, MC, Davis, PH, Datto, M, Li, Z, Gockerman, JP, Moore, JO, DeCastro, CM, Friedman, DR, Diehl, LF, Rehder, C, Cook, H, Daugherty, FJ, Matta, KMB, Weinberg, JB, and Rizzieri, D. "Phase II study of cenersen, an antisense inhibitor of p53, in combination with fludarabine, cyclophosphamide and rituximab for high-risk chronic lymphocytic leukemia." Leuk Lymphoma 53, no. 2 (February 2012): 218-224. Full Text Link to Item
  - Weck, KE, Zehnbauer, B, Datto, M, and Schrijver, I. "Molecular genetic testing for fragile X syndrome: Laboratory performance on the College of American Pathologists proficiency surveys (2001-2009)." Genetics in Medicine 14, no. 3 (2012): 306-312. Full Text
  - Gatza, CE, Holtzhausen, A, Kirkbride, KC, Morton, A, Gatza, ML, Datto, MB, and Blobe, GC. "Type III TGF-β receptor enhances colon cancer cell migration and anchorage-independent growth." Neoplasia 13, no. 8 (August 2011): 758-770. Link to Item
  - Wang, E, Hutchinson, CB, Huang, Q, Lu, CM, Crow, J, Wang, FF, Sebastian, S, Rehder, C, Lagoo, A, Horwitz, M, Rizzieri, D, Yu, J, Goodman, B, Datto, M, and Buckley, P. "Donor cell-derived leukemias/myelodysplastic neoplasms in allogeneic hematopoietic stem cell transplant recipients: a clinicopathologic study of 10 cases and a comprehensive review of the literature." American Journal of Clinical Pathology 135, no. 4 (April 2011): 525-540. (Review) Full Text
  - Wang, E, Papalas, J, Hutchinson, CB, Kulbacki, E, Huang, Q, Sebastian, S, Rehder, C, Silbermins, D, Moore, J, and Datto, M. "Sequential development of histiocytic sarcoma and diffuse large b-cell lymphoma in a patient with a remote history of follicular lymphoma with genotypic evidence of a clonal relationship: a divergent (bilineal) neoplastic transformation of an indolent B-cell lymphoma in a single individual." Am J Surg Pathol 35, no. 3 (March 2011): 457-463. Full Text Link to Item
  - Crow, J, Youens, K, Michalowski, S, Perrine, G, Emhart, C, Johnson, F, Gerling, A, Kurtzberg, J, Goodman, BK, Sebastian, S, Rehder, CW, and Datto, MB. "Donor cell leukemia in umbilical cord blood transplant patients: a case study and literature review highlighting the importance of molecular engraftment analysis." J Mol Diagn 12, no. 4 (July 2010): 530-537. (Review) Full Text Link to Item
  - Barry, W, Acharya, C, Datto, MB, Dressman, HK, Marcom, PK, Ready, N, Ginsburg, GS, Potti, A, and Nevins, JR. "Utilization of genomic signatures for chemotherapy response in prospective clinical studies." Journal of Clinical Oncology 28, no. 15_suppl (May 20, 2010): 10513-10513. Full Text
  - Pan, H, Ding, E, Hu, M, Lagoo, AS, Datto, MB, and Lagoo-Deenadayalan, SA. "SMAD4 is required for development of maximal endotoxin tolerance." J Immunol 184, no. 10 (May 15, 2010): 5502-5509. Full Text Link to Item
  - Barry, WT, Kernagis, DN, Dressman, HK, Griffis, RJ, Hunter, JD, Olson, JA, Marks, JR, Ginsburg, GS, Marcom, PK, Nevins, JR, Geradts, J, and Datto, MB. "Intratumor heterogeneity and precision of microarray-based predictors of breast cancer biology and clinical outcome." Journal of Clinical Oncology 28, no. 13 (May 2010): 2198-2206. Full Text
  - Gatza, ML, Lucas, JE, Barry, WT, Kim, JW, Wang, Q, Crawford, MD, Datto, MB, Kelley, M, Mathey-Prevot, B, Potti, A, and Nevins, JR. "A pathway-based classification of human breast cancer." Proceedings of the National Academy of Sciences of the United States of America 107, no. 15 (April 2010): 6994-6999. Full Text
  - Schilling, SH, Hjelmeland, AB, Radiloff, DR, Liu, IM, Wakeman, TP, Fielhauer, JR, Foster, EH, Lathia, JD, Rich, JN, Wang, X-F, and Datto, MB. "NDRG4 is required for cell cycle progression and survival in glioblastoma cells." The Journal of Biological Chemistry 284, no. 37 (September 2009): 25160-25169. Full Text
  - Horbinski, C, Dacic, S, McLendon, RE, Cieply, K, Datto, M, Brat, DJ, and Chu, CT. "Chordoid glioma: a case report and molecular characterization of five cases." Brain Pathol 19, no. 3 (July 2009): 439-448. Full Text Link to Item
  - Wooldridge, AA, Fortner, CN, Lontay, B, Akimoto, T, Neppl, RL, Facemire, C, Datto, MB, Kwon, A, McCook, E, Li, P, Wang, S, Thresher, RJ, Miller, SE, Perriard, J-C, Gavin, TP, Hickner, RC, Coffman, TM, Somlyo, AV, Yan, Z, and Haystead, TAJ. "Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle." The Journal of Biological Chemistry 283, no. 17 (April 2008): 11850-11859. Full Text
  - Ma, C, Rong, Y, Radiloff, DR, Datto, MB, Centeno, B, Bao, S, Cheng, AWM, Lin, F, Jiang, S, Yeatman, TJ, and Wang, X-F. "Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation." Genes & Development 22, no. 3 (February 2008): 308-321. Full Text
  - Kwiek, NC, Thacker, DF, Datto, MB, Megosh, HB, and Haystead, TAJ. "PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K." Cell Signal 18, no. 10 (October 2006): 1769-1778. Full Text Link to Item
  - Schilling, SH, Datto, MB, and Wang, X-F. "A phosphatase controls the fate of receptor-regulated Smads." Cell 125, no. 5 (June 2, 2006): 838-840. (Review) Full Text Link to Item
  - Robboy, SJ, and Datto, MB. "Synchronous endometrial and ovarian tumors: metastatic disease or independent primaries?." Hum Pathol 36, no. 6 (June 2005): 597-599. Full Text Link to Item
  - Datto, M, and Wang, X-F. "Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling." Cell 121, no. 1 (April 8, 2005): 2-4. Full Text Link to Item
  - "The proteome." (December 20, 2004): 153-178. (Chapter)
  - Moore-Maxwell, CA, Datto, MB, and Hulette, CM. "Chemotherapy-induced toxic leukoencephalopathy causes a wide range of symptoms: a series of four autopsies." Mod Pathol 17, no. 2 (February 2004): 241-247. Full Text Link to Item
  - Zhao, J, Shi, W, Wang, Y-L, Chen, H, Bringas, P, Datto, MB, Frederick, JP, Wang, X-F, and Warburton, D. "Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice." American Journal of Physiology. Lung Cellular and Molecular Physiology 282, no. 3 (March 2002): L585-L593. Full Text
  - Datto, MB, Moore-Maxwell, CA, and Hulette, C. "Chemotherapy induced leukoencephalopathy causes a wide range of symptoms: A series of three autopsies." MODERN PATHOLOGY 15, no. 1 (January 2002): 5A-5A. Link to Item
  - Datto, MB, Moore-Maxwell, CA, and Hulette, C. "Chemotherapy induced leukoencephalopathy causes a wide range of symptoms: A series of three autopsies." LABORATORY INVESTIGATION 82, no. 1 (January 2002): 5A-5A. Link to Item
  - Borton, AJ, Frederick, JP, Datto, MB, Wang, XF, and Weinstein, RS. "The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research 16, no. 10 (October 2001): 1754-1764. Full Text
  - Decesse, JT, Medjkane, S, Datto, MB, and Crémisi, CE. "RB regulates transcription of the p21/WAF1/CIP1 gene." Oncogene 20, no. 8 (February 22, 2001): 962-971. Full Text Link to Item
  - Borton, AJ, Frederick, JP, Datto, MB, Wang, X, and Weinstein, RS. "An essential role for Smad3 in bone formation through regulation of osteoblast differentiation." JOURNAL OF BONE AND MINERAL RESEARCH 15 (September 2000): S189-S189. Link to Item
  - Datto, M, and Wang, XF. "The Smads: transcriptional regulation and mouse models." Cytokine & Growth Factor Reviews 11, no. 1-2 (March 2000): 37-48. (Review) Full Text
  - Rich, JN, Zhang, M, Datto, MB, Bigner, DD, and Wang, XF. "Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines." The Journal of Biological Chemistry 274, no. 49 (December 1999): 35053-35058. Full Text
  - Kivinen, L, Tsubari, M, Haapajärvi, T, Datto, MB, Wang, XF, and Laiho, M. "Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites." Oncogene 18, no. 46 (November 1999): 6252-6261. Full Text
  - Billon, N, Carlisi, D, Datto, MB, van Grunsven, LA, Watt, A, Wang, XF, and Rudkin, BB. "Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation." Oncogene 18, no. 18 (May 6, 1999): 2872-2882. Full Text Link to Item
  - Datto, MB, Frederick, JP, Pan, L, Borton, AJ, Zhuang, Y, and Wang, XF. "Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction." Molecular and Cellular Biology 19, no. 4 (April 1999): 2495-2504. Full Text
  - Haapajärvi, T, Kivinen, L, Heiskanen, A, des Bordes, C, Datto, MB, Wang, XF, and Laiho, M. "UV radiation is a transcriptional inducer of p21(Cip1/Waf1) cyclin-kinase inhibitor in a p53-independent manner." Experimental Cell Research 248, no. 1 (April 1999): 272-279. Full Text
  - Liberati, NT, Datto, MB, Frederick, JP, Shen, X, Wong, C, Rougier-Chapman, EM, and Wang, XF. "Smads bind directly to the Jun family of AP-1 transcription factors." Proceedings of the National Academy of Sciences of the United States of America 96, no. 9 (April 1999): 4844-4849. Full Text
  - Wong, C, Rougier-Chapman, EM, Frederick, JP, Datto, MB, Liberati, NT, Li, JM, and Wang, XF. "Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta." Mol Cell Biol 19, no. 3 (March 1999): 1821-1830. Link to Item
  - Shen, X, Hu, PP, Liberati, NT, Datto, MB, Frederick, JP, and Wang, XF. "TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein." Molecular Biology of the Cell 9, no. 12 (December 1998): 3309-3319. Full Text
  - Hu, PP, Datto, MB, and Wang, XF. "Molecular mechanisms of transforming growth factor-beta signaling." Endocrine Reviews 19, no. 3 (June 1998): 349-363. (Review) Full Text
  - Li, JM, Datto, MB, Shen, X, Hu, PP, Yu, Y, and Wang, XF. "Sp1, but not Sp3, functions to mediate promoter activation by TGF-beta through canonical Sp1 binding sites." Nucleic Acids Res 26, no. 10 (May 15, 1998): 2449-2456. Link to Item
  - Frederick, JP, and Wang, XF. "TGF-β-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein." Molecular Biology of the Cell 9, no. 12 (January 1, 1998): 3309-3319. Full Text
  - Yingling, JM, Datto, MB, Wong, C, Frederick, JP, Liberati, NT, and Wang, XF. "Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein." Mol Cell Biol 17, no. 12 (December 1997): 7019-7028. Link to Item
  - Datto, MB, Hu, PP, Kowalik, TF, Yingling, J, and Wang, XF. "The viral oncoprotein E1A blocks transforming growth factor beta-mediated induction of p21/WAF1/Cip1 and p15/INK4B." Mol Cell Biol 17, no. 4 (April 1997): 2030-2037. Link to Item
  - Datto, MB, Bassing, CH, and Wang, X-F. "The TGFβ receptors and signaling pathways." (1996): 395-432. Full Text
  - Datto, MB, Yu, Y, and Wang, XF. "Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter." J Biol Chem 270, no. 48 (December 1, 1995): 28623-28628. Link to Item
  - Datto, MB, Li, Y, Panus, JF, Howe, DJ, Xiong, Y, and Wang, XF. "Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism." Proceedings of the National Academy of Sciences of the United States of America 92, no. 12 (June 1995): 5545-5549. Full Text
  - Schwarz, JK, Bassing, CH, Kovesdi, I, Datto, MB, Blazing, M, George, S, Wang, XF, and Nevins, JR. "Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression." Proc Natl Acad Sci U S A 92, no. 2 (January 17, 1995): 483-487. Link to Item
  - Frederick, JP, Wang, XF, and Warburton, D. "Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice." American Journal of Physiology Lung Cellular and Molecular Physiology 282, no. 3 26-3 (June 29, 2002).
- Book Sections
  - Datto, M, and Lundblad, RL. "DNA, RNA Chemical Properties (Including Sequencing and Next-Generation Sequencing)." In Encyclopedia of Cell Biology, 24-35.: Elsevier, 2016. Full Text
Teaching & Mentoring
Recent Courses
- PATHOL 793: Research Independent Study 2018

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles

Book Sections

Recent Courses