Michael Bradley Datto
Associate Professor of Pathology
Dr. Datto is an AP/CP/MGP board certified pathologist who specializes in molecular pathology. He is the Associate Vice President for Duke University Health System Clinical Laboratories, the Vice Chair for Clinical Pathology and Medical Director for Duke University Health System Clinical Laboratories.
In these roles, he is responsible for maintaining the standards of the College of American Pathologists and CLIA/CMS within all Clinical Laboratories at Duke. Specifically, Dr. Datto oversees clinical testing and reporting, develops quality management systems and proficiency testing programs, provides consultation with ordering physicians, ensures educational programs, develops strategic plans that are in line with the needs of our patient population, physicians and health system leadership, coordinates research and development, ensures adequate and appropriately trained personnel, and provides profession interpretation for molecular diagnostic testing including the wide range of PCR, quantitative PCR, sequencing and FISH based tests for inherited genetic diseases, hematologic malignancies, solid tumors and infectious diseases.
Dr. Datto also serves as the chair of the Accreditation Committee (AC) for the College of American Pathologists (CAP). The CAP is the largest accreditor of hospital based laboratories in the US and serves as a ‘deemed entity’ by the Center for Medicare Services. In his role of chair of the AC, Dr. Datto oversees the committee that makes clinical accreditation decisions for approximately 7,000 clinical domestic and international laboratories.
Finally, Dr. Datto has an active academic program developing data system to aggregate, normalize and utilize high complexity and high volume laboratory data. Dr. Datto and his team have developed the Molecular Registry of Tumors (Mr.T); a software solution that supports clinical trials matching, engagement with the AACR GENIE Project and the Molecular Tumor Board for Duke University Health System. The ultimate goal of this work is to ensure that the vast amount of laboratory data generated on our Duke patients can be put to use, driving better patient care, research and education.
Current Appointments & Affiliations
- Associate Professor of Pathology, Pathology, Clinical Science Departments 2012
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1995
Contact Information
- Dept of Pathology, Durham, NC 27710
- Duke Box 3712, Durham, NC 27710
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michael.datto@duke.edu
(919) 684-6965
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DukeMolecular
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Pathologypics
- Background
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Education, Training, & Certifications
- Resident, Pathology, Duke University 2000 - 2004
- Postdoctoral Fellow, Pharmacology, Duke University 1999 - 2000
- M.D., Duke University 1999
- Ph.D., Duke University 1998
- B.A., Johns Hopkins University 1991
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Previous Appointments & Affiliations
- Assistant Professor of Pathology, Pathology, Clinical Science Departments 2004 - 2012
- Instructor, Temporary of Pathology, Pathology, Clinical Science Departments 2004
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Leadership & Clinical Positions at Duke
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Director and Associate Vice President Duke Health System Clinical Laboratories
Vice Chair for Clinical Pathology, Duke University School of Medicine
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Director and Associate Vice President Duke Health System Clinical Laboratories
- Recognition
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In the News
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JAN 20, 2021 Pratt School of Engineering
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- Research
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Selected Grants
- Adapting K-MDS to detect KRAS-mutant ctDNA awarded by National Institutes of Health 2022 - 2025
- Cooperative Human Tissue Network Support through Duke's BioRepository & Precision Pathology Center awarded by National Institutes of Health 2019 - 2024
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Non Muscle Myosin II Contractility Putatively Regulates Scar Contracture awarded by National Institutes of Health 2008 - 2013
- Programs in Clinical Effectiveness of Cancer Pharmacogenomics awarded by National Institutes of Health 2009 - 2012
- Validating Molecular Signature Risk Models of NSCLC awarded by National Institutes of Health 2006 - 2012
- Intellectual Property Challenges for the Development of Genomic Diagnostics awarded by National Institutes of Health 2009 - 2012
- Gene Targeted Therapy of Brain Tumors awarded by National Institutes of Health 2009 - 2012
- Prospective Validation of Genomic Signatures of Chemosensitivity in NSCLC awarded by National Institutes of Health 2009 - 2010
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Van Egeren, Debra, Khushi Kohli, Jeremy L. Warner, Philippe L. Bedard, Gregory Riely, Eva Lepisto, Deborah Schrag, et al. “Genomic analysis of early-stage lung cancer reveals a role for TP53 mutations in distant metastasis.” Sci Rep 12, no. 1 (November 9, 2022): 19055. https://doi.org/10.1038/s41598-022-21448-1.Full Text Link to Item
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Scholl, Ashley Rose, Dimitrios Korentzelos, Taylor E. Forns, Ethan K. Brenneman, Matthew Kelm, Michael Datto, Sarah E. Wheeler, and Eric D. Carlsen. “Characterization of Casirivimab Plus Imdevimab, Sotrovimab, and Bamlanivimab Plus Etesevimab-Derived Interference in Serum Protein Electrophoresis and Immunofixation Electrophoresis.” J Appl Lab Med 7, no. 6 (October 29, 2022): 1379–87. https://doi.org/10.1093/jalm/jfac064.Full Text Link to Item
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Keefer, Laurel A., James R. White, Derrick E. Wood, Kelly M. R. Gerding, Kenneth C. Valkenburg, David Riley, Christopher Gault, et al. “Automated next-generation profiling of genomic alterations in human cancers.” Nat Commun 13, no. 1 (May 20, 2022): 2830. https://doi.org/10.1038/s41467-022-30380-x.Full Text Link to Item
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Kao, Chester, Eric Powers, Yuan Wu, Michael B. Datto, Michelle F. Green, John H. Strickler, Neal E. Ready, Tian Zhang, and Jeffrey M. Clarke. “Predictive Value of Combining Biomarkers for Clinical Outcomes in Advanced Non-Small Cell Lung Cancer Patients Receiving Immune Checkpoint Inhibitors.” Clinical Lung Cancer 22, no. 6 (November 2021): 500–509. https://doi.org/10.1016/j.cllc.2021.03.017.Full Text
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Deak, Kristen L., Jennifer B. Jackson, Kenneth C. Valkenburg, Laurel A. Keefer, Kelly M. Robinson Gerding, Samuel V. Angiuoli, Michael B. Datto, and Shannon J. McCall. “Next-Generation Sequencing Concordance Analysis of Comprehensive Solid Tumor Profiling between a Centralized Specialty Laboratory and the Decentralized Personal Genome Diagnostics elio Tissue Complete Kitted Solution.” J Mol Diagn 23, no. 10 (October 2021): 1324–33. https://doi.org/10.1016/j.jmoldx.2021.07.004.Full Text Link to Item
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Takeda, Kotaro, Rhonda Mittenzwei, Kim R. Geisinger, Michael B. Datto, and Lorita M. Rebellato. “Donor-Derived Neuroendocrine Carcinoma Transmission to Two Kidney Transplant Recipients Demonstrated by Short Tandem Repeat Analysis: A Case Report.” Transplant Proc 53, no. 4 (May 2021): 1337–41. https://doi.org/10.1016/j.transproceed.2021.03.002.Full Text Link to Item
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Lewis, Sarah S., Becky A. Smith, Ibukunoluwa C. Akinboyo, Jessica Seidelman, Cameron Wolfe, Allan B. Kirk, Gavin Martin, et al. “Early experience with universal preprocedural testing for SARS-CoV-2 in a relatively low-prevalence area.” Infect Control Hosp Epidemiol 42, no. 3 (March 2021): 341–43. https://doi.org/10.1017/ice.2020.398.Full Text Open Access Copy Link to Item
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Green, Michelle F., Jonathan L. Bell, Christopher B. Hubbard, Shannon J. McCall, Matthew S. McKinney, Jinny E. Riedel, Carolyn S. Menendez, James L. Abbruzzese, John H. Strickler, and Michael B. Datto. “Implementation of a Molecular Tumor Registry to Support the Adoption of Precision Oncology Within an Academic Medical Center: The Duke University Experience.” Jco Precision Oncology 5 (January 2021): PO.21.00030. https://doi.org/10.1200/po.21.00030.Full Text
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Watson, Catherine H., Gloria Broadwater, Janice Wong, Daniel Spinosa, Mary Katherine Montes de Oca, Michael Datto, Michelle Green, et al. “Results and Clinical Utilization of Foundation Medicine Molecular Tumor Profiling in Uterine and Ovarian Cancers.” Target Oncol 16, no. 1 (January 2021): 109–18. https://doi.org/10.1007/s11523-020-00785-z.Full Text Link to Item
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Polage, Christopher R., Mark J. Lee, Christopher Hubbard, Catherine Rehder, Diana Cardona, Thomas Denny, and Michael B. Datto. “Assessment of an Online Tool to Simulate the Effect of Pooled Testing for SARS-CoV-2 Detection in Asymptomatic and Symptomatic Populations.” Jama Netw Open 3, no. 12 (December 1, 2020): e2031517. https://doi.org/10.1001/jamanetworkopen.2020.31517.Full Text Open Access Copy Link to Item
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Denny, Thomas N., Laura Andrews, Mattia Bonsignori, Kyle Cavanaugh, Michael B. Datto, Anastasia Deckard, C Todd DeMarco, et al. “Implementation of a Pooled Surveillance Testing Program for Asymptomatic SARS-CoV-2 Infections on a College Campus - Duke University, Durham, North Carolina, August 2-October 11, 2020.” Mmwr Morb Mortal Wkly Rep 69, no. 46 (November 20, 2020): 1743–47. https://doi.org/10.15585/mmwr.mm6946e1.Full Text Open Access Copy Link to Item
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Tan, Irena, Thomas E. Stinchcombe, Neal E. Ready, Jeffrey Crawford, Michael B. Datto, Rebecca J. Nagy, Richard B. Lanman, Lin Gu, and Jeffrey M. Clarke. “Therapeutic outcomes in non-small cell lung cancer with BRAF mutations: a single institution, retrospective cohort study.” Transl Lung Cancer Res 8, no. 3 (June 2019): 258–67. https://doi.org/10.21037/tlcr.2019.04.03.Full Text Link to Item
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Altunel, Erdem, Abed Alhalim Aljamal, John Mantyh, Kristen Deak, Wayne Glover, Shannon J. McCall, Michael Datto, John Strickler, and David S. Hsu. “Characterization of the Epidermal Growth Factor Receptor T790M Mutation in Colorectal Cancer.” Jco Precis Oncol 2 (November 2018): 1–7. https://doi.org/10.1200/PO.18.00194.Full Text Link to Item
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Korkut, Anil, Sobia Zaidi, Rupa S. Kanchi, Shuyun Rao, Nancy R. Gough, Andre Schultz, Xubin Li, et al. “A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily.” Cell Syst 7, no. 4 (October 24, 2018): 422-437.e7. https://doi.org/10.1016/j.cels.2018.08.010.Full Text Link to Item
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Jug, Rachel C., Michael B. Datto, and Xiaoyin Sara Jiang. “Molecular testing for indeterminate thyroid nodules: Performance of the Afirma gene expression classifier and ThyroSeq panel.” Cancer Cytopathol 126, no. 7 (July 2018): 471–80. https://doi.org/10.1002/cncy.21993.Full Text Link to Item
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Li, Marilyn M., Michael Datto, Eric J. Duncavage, Shashikant Kulkarni, Neal I. Lindeman, Somak Roy, Apostolia M. Tsimberidou, et al. “Authors' Reply.” J Mol Diagn 20, no. 1 (January 2018): 125–26. https://doi.org/10.1016/j.jmoldx.2017.11.002.Full Text Link to Item
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Jiang, Xiaoyin Sara, Grant P. Harrison, and Michael B. Datto. “Reply to Young Investigator Challenge: Molecular testing in noninvasive follicular thyroid neoplasm with papillary-like nuclear features.” Cancer Cytopathol 125, no. 4 (April 2017): 293–94. https://doi.org/10.1002/cncy.21829.Full Text Link to Item
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Li, Marilyn M., Michael Datto, Eric J. Duncavage, Shashikant Kulkarni, Neal I. Lindeman, Somak Roy, Apostolia M. Tsimberidou, et al. “Standards and Guidelines for the Interpretation and Reporting of Sequence Variants in Cancer: A Joint Consensus Recommendation of the Association for Molecular Pathology, American Society of Clinical Oncology, and College of American Pathologists.” J Mol Diagn 19, no. 1 (January 2017): 4–23. https://doi.org/10.1016/j.jmoldx.2016.10.002.Full Text Link to Item
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Jiang, Xiaoyin Sara, Grant P. Harrison, and Michael B. Datto. “Young Investigator Challenge: Molecular testing in noninvasive follicular thyroid neoplasm with papillary-like nuclear features.” Cancer Cytopathol 124, no. 12 (December 2016): 893–900. https://doi.org/10.1002/cncy.21802.Full Text Link to Item
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Tafe, Laura J., Michael B. Datto, Glenn E. Palomaki, Felicitas L. Lacbawan, and Felicitas L. CAP/ACMG Biochemical and Molecular Genetics Resource Committee. “Molecular testing for the BRCA1 and BRCA2 Ashkenazi Jewish founder mutations: a report on the College of American Pathologists proficiency testing surveys.” Genet Med 17, no. 1 (January 2015): 58–62. https://doi.org/10.1038/gim.2014.77.Full Text Link to Item
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McCall, Chad M., Stacy Mosier, Michele Thiess, Marija Debeljak, Aparna Pallavajjala, Katie Beierl, Kristen L. Deak, et al. “False positives in multiplex PCR-based next-generation sequencing have unique signatures.” J Mol Diagn 16, no. 5 (September 2014): 541–49. https://doi.org/10.1016/j.jmoldx.2014.06.001.Full Text Link to Item
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Stevenson, Marvaretta, Jared Christensen, Debra Shoemaker, Traci Foster, William T. Barry, Betty C. Tong, Momen Wahidi, et al. “Tumor acquisition for biomarker research in lung cancer.” Cancer Invest 32, no. 6 (July 2014): 291–98. https://doi.org/10.3109/07357907.2014.911880.Full Text Link to Item
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Haga, Susanne B., Rachel Mills, Kathryn I. Pollak, Catherine Rehder, Adam H. Buchanan, Isaac M. Lipkus, Jennifer H. Crow, and Michael Datto. “Developing patient-friendly genetic and genomic test reports: formats to promote patient engagement and understanding.” Genome Med 6, no. 7 (2014): 58. https://doi.org/10.1186/s13073-014-0058-6.Full Text Link to Item
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Landi, Daniel, Evelyn Lockhart, Sara E. Miller, Michael Datto, Catherine Rehder, Angela Kanaly, and Courtney D. Thornburg. “Report of a young girl with MYH9 mutation and review of the literature.” J Pediatr Hematol Oncol 34, no. 7 (October 2012): 538–40. https://doi.org/10.1097/MPH.0b013e3182678fc9.Full Text Open Access Copy Link to Item
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Kim, Mickey K., Takuya Osada, William T. Barry, Xiao Yi Yang, Jennifer A. Freedman, Katherine A. Tsamis, Michael Datto, et al. “Characterization of an oxaliplatin sensitivity predictor in a preclinical murine model of colorectal cancer.” Mol Cancer Ther 11, no. 7 (July 2012): 1500–1509. https://doi.org/10.1158/1535-7163.MCT-11-0937.Full Text Link to Item
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Hutchinson, Charles Blake, Maggie Stoecker, Frances F. Wang, John Papalas, Siby Sebastian, James Burchette, Michael Datto, and Endi Wang. “Molecular detection of circulating Sezary cells in patients with mycosis fungoides: could it predict future development of secondary Sezary syndrome? A single-institution experience.” Leuk Lymphoma 53, no. 5 (May 2012): 868–77. https://doi.org/10.3109/10428194.2011.633408.Full Text Link to Item
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Weck, Karen E., Barbara Zehnbauer, Michael Datto, Iris Schrijver, and Iris CAP/ACMG Biochemical and Molecular Genetics Resource Committee. “Molecular genetic testing for fragile X syndrome: laboratory performance on the College of American Pathologists proficiency surveys (2001-2009).” Genet Med 14, no. 3 (March 2012): 306–12. https://doi.org/10.1038/gim.2011.11.Full Text Link to Item
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Lanasa, Mark C., Patricia H. Davis, Michael Datto, Zhiguo Li, Jon P. Gockerman, Joseph O. Moore, Carlos M. DeCastro, et al. “Phase II study of cenersen, an antisense inhibitor of p53, in combination with fludarabine, cyclophosphamide and rituximab for high-risk chronic lymphocytic leukemia.” Leuk Lymphoma 53, no. 2 (February 2012): 218–24. https://doi.org/10.3109/10428194.2011.610012.Full Text Link to Item
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Kernagis, Dawn N., Allison H. S. Hall, and Michael B. Datto. “Genes with bimodal expression are robust diagnostic targets that define distinct subtypes of epithelial ovarian cancer with different overall survival.” J Mol Diagn 14, no. 3 (2012): 214–22. https://doi.org/10.1016/j.jmoldx.2012.01.007.Full Text Link to Item
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Gatza, Catherine E., Alisha Holtzhausen, Kellye C. Kirkbride, Allyson Morton, Michael L. Gatza, Michael B. Datto, and Gerard C. Blobe. “Type III TGF-β receptor enhances colon cancer cell migration and anchorage-independent growth.” Neoplasia 13, no. 8 (August 2011): 758–70. https://doi.org/10.1593/neo.11528.Full Text Link to Item
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Wang, Endi, Charles Blake Hutchinson, Qin Huang, Chuanyi Mark Lu, Jennifer Crow, Frances F. Wang, Siby Sebastian, et al. “Donor cell-derived leukemias/myelodysplastic neoplasms in allogeneic hematopoietic stem cell transplant recipients: a clinicopathologic study of 10 cases and a comprehensive review of the literature.” Am J Clin Pathol 135, no. 4 (April 2011): 525–40. https://doi.org/10.1309/AJCPPJUQ9DNR1GHP.Full Text Link to Item
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Wang, Endi, John Papalas, Charles Blake Hutchinson, Evan Kulbacki, Qin Huang, Siby Sebastian, Catherine Rehder, Damian Silbermins, Joseph Moore, and Michael Datto. “Sequential development of histiocytic sarcoma and diffuse large b-cell lymphoma in a patient with a remote history of follicular lymphoma with genotypic evidence of a clonal relationship: a divergent (bilineal) neoplastic transformation of an indolent B-cell lymphoma in a single individual.” Am J Surg Pathol 35, no. 3 (March 2011): 457–63. https://doi.org/10.1097/PAS.0b013e3182098799.Full Text Link to Item
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Crow, Jennifer, Kenneth Youens, Susan Michalowski, Gail Perrine, Cassandra Emhart, Felicia Johnson, Amy Gerling, et al. “Donor cell leukemia in umbilical cord blood transplant patients: a case study and literature review highlighting the importance of molecular engraftment analysis.” J Mol Diagn 12, no. 4 (July 2010): 530–37. https://doi.org/10.2353/jmoldx.2010.090215.Full Text Open Access Copy Link to Item
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Barry, W., C. Acharya, M. B. Datto, H. K. Dressman, P. K. Marcom, N. Ready, G. S. Ginsburg, A. Potti, and J. R. Nevins. “Utilization of genomic signatures for chemotherapy response in prospective clinical studies.” Journal of Clinical Oncology 28, no. 15_suppl (May 20, 2010): 10513–10513. https://doi.org/10.1200/jco.2010.28.15_suppl.10513.Full Text
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Pan, Hongjie, Enyu Ding, Mai Hu, Anand S. Lagoo, Michael B. Datto, and Sandhya A. Lagoo-Deenadayalan. “SMAD4 is required for development of maximal endotoxin tolerance.” J Immunol 184, no. 10 (May 15, 2010): 5502–9. https://doi.org/10.4049/jimmunol.0901601.Full Text Link to Item
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Barry, William T., Dawn N. Kernagis, Holly K. Dressman, Ryan J. Griffis, J’vonne D. Hunter, John A. Olson, Jeff R. Marks, et al. “Intratumor heterogeneity and precision of microarray-based predictors of breast cancer biology and clinical outcome.” J Clin Oncol 28, no. 13 (May 1, 2010): 2198–2206. https://doi.org/10.1200/JCO.2009.26.7245.Full Text Link to Item
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Gatza, Michael L., Joseph E. Lucas, William T. Barry, Jong Wook Kim, Quanli Wang, Matthew D. Crawford, Michael B. Datto, et al. “A pathway-based classification of human breast cancer.” Proc Natl Acad Sci U S A 107, no. 15 (April 13, 2010): 6994–99. https://doi.org/10.1073/pnas.0912708107.Full Text Link to Item
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Schilling, Stephen H., Anita B. Hjelmeland, Daniel R. Radiloff, Irwin M. Liu, Timothy P. Wakeman, Jeffrey R. Fielhauer, Erika H. Foster, et al. “NDRG4 is required for cell cycle progression and survival in glioblastoma cells.” J Biol Chem 284, no. 37 (September 11, 2009): 25160–69. https://doi.org/10.1074/jbc.M109.012484.Full Text Link to Item
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Horbinski, Craig, Sanja Dacic, Roger E. McLendon, Kathy Cieply, Michael Datto, Daniel J. Brat, and Charleen T. Chu. “Chordoid glioma: a case report and molecular characterization of five cases.” Brain Pathol 19, no. 3 (July 2009): 439–48. https://doi.org/10.1111/j.1750-3639.2008.00196.x.Full Text Link to Item
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Wooldridge, Anne A., Christopher N. Fortner, Beata Lontay, Takayuki Akimoto, Ronald L. Neppl, Carie Facemire, Michael B. Datto, et al. “Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle.” J Biol Chem 283, no. 17 (April 25, 2008): 11850–59. https://doi.org/10.1074/jbc.M708628200.Full Text Link to Item
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Ma, Chaoyu, Yu Rong, Daniel R. Radiloff, Michael B. Datto, Barbara Centeno, Shideng Bao, Anthony Wai Ming Cheng, et al. “Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation.” Genes Dev 22, no. 3 (February 1, 2008): 308–21. https://doi.org/10.1101/gad.1632008.Full Text Link to Item
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Kwiek, Nicole C., Drew F. Thacker, Michael B. Datto, Heather B. Megosh, and Timothy A. J. Haystead. “PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K.” Cell Signal 18, no. 10 (October 2006): 1769–78. https://doi.org/10.1016/j.cellsig.2006.01.019.Full Text Link to Item
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Schilling, Stephen H., Michael B. Datto, and Xiao-Fan Wang. “A phosphatase controls the fate of receptor-regulated Smads.” Cell 125, no. 5 (June 2, 2006): 838–40. https://doi.org/10.1016/j.cell.2006.05.015.Full Text Link to Item
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Robboy, Stanley J., and Michael B. Datto. “Synchronous endometrial and ovarian tumors: metastatic disease or independent primaries?” Hum Pathol 36, no. 6 (June 2005): 597–99. https://doi.org/10.1016/j.humpath.2005.05.012.Full Text Link to Item
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Datto, M., and X. -. F. Wang. “Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling.” Cell 121, no. 1 (April 8, 2005): 2–4. https://doi.org/10.1016/j.cell.2005.03.017.Full Text Link to Item
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Datto, M. B., and T. A. J. Haystead. “The proteome,” December 20, 2004, 153–78.
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Moore-Maxwell, Crystal A., Michael B. Datto, and Christine M. Hulette. “Chemotherapy-induced toxic leukoencephalopathy causes a wide range of symptoms: a series of four autopsies.” Mod Pathol 17, no. 2 (February 2004): 241–47. https://doi.org/10.1038/modpathol.3800049.Full Text Link to Item
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Zhao, Jingsong, Wei Shi, Yan-Ling Wang, Hui Chen, Pablo Bringas, Michael B. Datto, Joshua P. Frederick, Xiao-Fan Wang, and David Warburton. “Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice.” Am J Physiol Lung Cell Mol Physiol 282, no. 3 (March 2002): L585–93. https://doi.org/10.1152/ajplung.00151.2001.Full Text Link to Item
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Datto, M. B., C. A. Moore-Maxwell, and C. Hulette. “Chemotherapy induced leukoencephalopathy causes a wide range of symptoms: A series of three autopsies.” Modern Pathology 15, no. 1 (January 1, 2002): 5A-5A.Link to Item
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Datto, M. B., C. A. Moore-Maxwell, and C. Hulette. “Chemotherapy induced leukoencephalopathy causes a wide range of symptoms: A series of three autopsies.” Laboratory Investigation 82, no. 1 (January 1, 2002): 5A-5A.Link to Item
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Borton, A. J., J. P. Frederick, M. B. Datto, X. F. Wang, and R. S. Weinstein. “The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis.” J Bone Miner Res 16, no. 10 (October 2001): 1754–64. https://doi.org/10.1359/jbmr.2001.16.10.1754.Full Text Link to Item
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Decesse, J. T., S. Medjkane, M. B. Datto, and C. E. Crémisi. “RB regulates transcription of the p21/WAF1/CIP1 gene.” Oncogene 20, no. 8 (February 22, 2001): 962–71. https://doi.org/10.1038/sj.onc.1204169.Full Text Link to Item
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Borton, A. J., J. P. Frederick, M. B. Datto, X. Wang, and R. S. Weinstein. “An essential role for Smad3 in bone formation through regulation of osteoblast differentiation.” Journal of Bone and Mineral Research 15 (September 1, 2000): S189–S189.Link to Item
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Datto, M., and X. F. Wang. “The Smads: transcriptional regulation and mouse models.” Cytokine Growth Factor Rev 11, no. 1–2 (2000): 37–48. https://doi.org/10.1016/s1359-6101(99)00027-1.Full Text Link to Item
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Rich, J. N., M. Zhang, M. B. Datto, D. D. Bigner, and X. F. Wang. “Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines.” J Biol Chem 274, no. 49 (December 3, 1999): 35053–58. https://doi.org/10.1074/jbc.274.49.35053.Full Text Link to Item
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Kivinen, L., M. Tsubari, T. Haapajärvi, M. B. Datto, X. F. Wang, and M. Laiho. “Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites.” Oncogene 18, no. 46 (November 4, 1999): 6252–61. https://doi.org/10.1038/sj.onc.1203000.Full Text Link to Item
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Billon, N., D. Carlisi, M. B. Datto, L. A. van Grunsven, A. Watt, X. F. Wang, and B. B. Rudkin. “Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation.” Oncogene 18, no. 18 (May 6, 1999): 2872–82. https://doi.org/10.1038/sj.onc.1202712.Full Text Link to Item
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Liberati, N. T., M. B. Datto, J. P. Frederick, X. Shen, C. Wong, E. M. Rougier-Chapman, and X. F. Wang. “Smads bind directly to the Jun family of AP-1 transcription factors.” Proc Natl Acad Sci U S A 96, no. 9 (April 27, 1999): 4844–49. https://doi.org/10.1073/pnas.96.9.4844.Full Text Link to Item
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Haapajärvi, T., L. Kivinen, A. Heiskanen, C. des Bordes, M. B. Datto, X. F. Wang, and M. Laiho. “UV radiation is a transcriptional inducer of p21(Cip1/Waf1) cyclin-kinase inhibitor in a p53-independent manner.” Exp Cell Res 248, no. 1 (April 10, 1999): 272–79. https://doi.org/10.1006/excr.1999.4403.Full Text Link to Item
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Datto, M. B., J. P. Frederick, L. Pan, A. J. Borton, Y. Zhuang, and X. F. Wang. “Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction.” Mol Cell Biol 19, no. 4 (April 1999): 2495–2504. https://doi.org/10.1128/MCB.19.4.2495.Full Text Link to Item
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Wong, C., E. M. Rougier-Chapman, J. P. Frederick, M. B. Datto, N. T. Liberati, J. M. Li, and X. F. Wang. “Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta.” Mol Cell Biol 19, no. 3 (March 1999): 1821–30. https://doi.org/10.1128/MCB.19.3.1821.Full Text Link to Item
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Shen, X., P. P. Hu, N. T. Liberati, M. B. Datto, J. P. Frederick, and X. F. Wang. “TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein.” Mol Biol Cell 9, no. 12 (December 1998): 3309–19. https://doi.org/10.1091/mbc.9.12.3309.Full Text Link to Item
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Hu, P. P., M. B. Datto, and X. F. Wang. “Molecular mechanisms of transforming growth factor-beta signaling.” Endocr Rev 19, no. 3 (June 1998): 349–63. https://doi.org/10.1210/edrv.19.3.0333.Full Text Link to Item
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Li, J. M., M. B. Datto, X. Shen, P. P. Hu, Y. Yu, and X. F. Wang. “Sp1, but not Sp3, functions to mediate promoter activation by TGF-beta through canonical Sp1 binding sites.” Nucleic Acids Res 26, no. 10 (May 15, 1998): 2449–56. https://doi.org/10.1093/nar/26.10.2449.Full Text Link to Item
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Yingling, J. M., M. B. Datto, C. Wong, J. P. Frederick, N. T. Liberati, and X. F. Wang. “Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein.” Mol Cell Biol 17, no. 12 (December 1997): 7019–28. https://doi.org/10.1128/MCB.17.12.7019.Full Text Link to Item
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Datto, M. B., P. P. Hu, T. F. Kowalik, J. Yingling, and X. F. Wang. “The viral oncoprotein E1A blocks transforming growth factor beta-mediated induction of p21/WAF1/Cip1 and p15/INK4B.” Mol Cell Biol 17, no. 4 (April 1997): 2030–37. https://doi.org/10.1128/MCB.17.4.2030.Full Text Link to Item
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Datto, M. B., C. H. Bassing, and X. F. Wang. “The TGFβ receptors and signaling pathways.” Growth Factors and Cytokines in Health and Disease 1, no. C (December 1, 1996): 395–432. https://doi.org/10.1016/S1874-5687(96)80017-6.Full Text
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Datto, M. B., Y. Yu, and X. F. Wang. “Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter.” J Biol Chem 270, no. 48 (December 1, 1995): 28623–28. https://doi.org/10.1074/jbc.270.48.28623.Full Text Link to Item
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Datto, M. B., Y. Li, J. F. Panus, D. J. Howe, Y. Xiong, and X. F. Wang. “Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.” Proc Natl Acad Sci U S A 92, no. 12 (June 6, 1995): 5545–49. https://doi.org/10.1073/pnas.92.12.5545.Full Text Link to Item
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Schwarz, J. K., C. H. Bassing, I. Kovesdi, M. B. Datto, M. Blazing, S. George, X. F. Wang, and J. R. Nevins. “Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression.” Proc Natl Acad Sci U S A 92, no. 2 (January 17, 1995): 483–87. https://doi.org/10.1073/pnas.92.2.483.Full Text Link to Item
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Book Sections
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Datto, M., and R. L. Lundblad. “DNA, RNA Chemical Properties (Including Sequencing and Next-Generation Sequencing).” In Encyclopedia of Cell Biology, 1:24–35, 2016. https://doi.org/10.1016/B978-0-12-394447-4.10006-9.Full Text
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