Overview
I am a physician scientist studying the molecular biology of interstitial lung diseases. The three main topics of my research program are 1) the roles of protein lipidation in pro-fibrotic TGF-beta receptor signaling, 2) lung metabolism of xenobiotics (i.e., drugs) by cytochrome P450 enzymes and 3) development of novel technologies to study protein lipidation including proteomics and genetic screening tools. My long-term goals are to unravel the molecular drivers of pulmonary fibrosis thus facilitating strategies to prevent and treat fibrotic lung diseases.
Current Duke Appointments & Affiliations
Medical Instructor in the Department of Medicine
·
2025 - Present
Medicine, Pulmonary, Allergy, and Critical Care Medicine,
Medicine
Recent Scholarly Works
Development and Validation of a Streamlined Workflow for Proteomic Analysis of Proteins and Post-translational Modifications from Dried Blood.
Journal article J Proteome Res · July 3, 2026 It is increasingly recognized that the 'omic analysis of whole blood has applications for precision medicine and disease phenotyping. Despite this realization, whole blood is generally viewed as a challenging analytical matrix in comparison to plasma or se ... Full text Link to item CiteAbstract 2021 Cytochrome P450 2B10 activates butylated hydroxytoluene (BHT) into a pro-apoptotic quinone methide: implications for human BHT exposure and chronic lung diseases
Conference Journal of Biological Chemistry · May 2026 Full text CiteTopology-driven discovery of transmembrane protein S-palmitoylation.
Journal article J Biol Chem · March 2025 Protein S-palmitoylation is a reversible lipophilic posttranslational modification regulating diverse signaling pathways. Within transmembrane proteins (TMPs), S-palmitoylation is implicated in conditions from inflammatory disorders to respiratory viral in ... Full text Link to item CiteRecent Grants
Role of Protein S-Palmitoylation in TGFbeta Signaling and Fibrotic Lung Disease
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2030View All Grants
Education
Duke University, School of Medicine ·
2010
M.D.
Duke University, School of Medicine ·
2009
Ph.D.