Overview
I am a physician scientist studying molecular mechanisms of fibroblast activation and pulmonary fibrosis. My research is at the intersection of signal transduction and protein-oriented technology developments. This include lipidation-oriented CRISPR screening tools and proteomic methodologies. My long-term goals are to discover drivers of pulmonary fibrosis leading to the development of novel treatment strategies.
Current Appointments & Affiliations
Medical Instructor in the Department of Medicine
·
2025 - Present
Medicine, Pulmonary, Allergy, and Critical Care Medicine,
Medicine
Recent Publications
Topology-driven discovery of transmembrane protein S-palmitoylation.
Journal Article J Biol Chem · March 2025 Protein S-palmitoylation is a reversible lipophilic posttranslational modification regulating diverse signaling pathways. Within transmembrane proteins (TMPs), S-palmitoylation is implicated in conditions from inflammatory disorders to respiratory viral in ... Full text Link to item CiteTopology-Driven Discovery of Transmembrane Protein S-Palmitoylation.
Journal Article bioRxiv · September 8, 2024 Protein S-palmitoylation is a reversible lipophilic posttranslational modification regulating a diverse number of signaling pathways. Within transmembrane proteins (TMPs), S-palmitoylation is implicated in conditions from inflammatory disorders to respirat ... Full text Link to item CiteAnalysis of Protein Cysteine Acylation Using a Modified Suspension Trap (Acyl-Trap).
Journal Article J Proteome Res · August 2, 2024 Proteins undergo reversible S-acylation via a thioester linkage in vivo. S-palmitoylation, modification by C16:0 fatty acid, is a common S-acylation that mediates critical protein-membrane and protein-protein interactions. The most widely used S-acylation ... Full text Link to item CiteEducation, Training & Certifications
Duke University, School of Medicine ·
2010
M.D.
Duke University, School of Medicine ·
2009
Ph.D.