Michael Wayne Manning
Associate Professor of Anesthesiology
Dr. Michael W. Manning, MD, PhD, is currently an Associate Professor at Duke University Medical Center, within the Divisions of Cardiothoracic and General, Vascular, Transplant anesthesia. He serves as the director of research for the Perioperative Medicine Fellowship at Duke. His clinical practice focuses on high risk cardiac surgery, Heart, Lung, and Liver transplantation.
Dr. Manning earned a PhD in cardiovascular physiology from the University of Kentucky where studied the role that Angiotensin II mediated inflammation plays in the development of abdominal aortic aneurysms. After graduate school, Dr. Manning remained at the University of Kentucky earning his MD degree. He completed a year of general surgery residency, before switching to anesthesia. Following residency, Dr.
Manning continued his clinical training at Duke University with a one-year clinical fellowship in Adult Cardiothoracic Anesthesiology and a 2-year research fellowship. He joined the Duke faculty in 2014.
His current research interests are ERAS centered, specifically in the areas of role of opioid-free anesthesia as well as goal directed fluid therapy in cardiac surgery on renal outcomes.
Office Hours
Friday 3pm-5pm
Current Appointments & Affiliations
- Associate Professor of Anesthesiology, Anesthesiology, General, Vascular, High Risk Transplant & Critical Care, Anesthesiology 2021
Contact Information
- Background
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Education, Training, & Certifications
- M.D., University of Kentucky, College of Medicine 2006
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Medical Licensure
- 172242. North Carolina. 2020
- 43498. Kentucky. 2020
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Previous Appointments & Affiliations
- Assistant Professor of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2021
- Assistant Professor of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2014 - 2020
- Medical Instructor in the Department of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2012 - 2014
- Research
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Selected Grants
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Dunkman, W Jonathan, David A. Williams, and Michael W. Manning. “Bleeding Complications from Transesophageal Echocardiography for Liver Transplantation: A Systematic Review.” Semin Cardiothorac Vasc Anesth 26, no. 4 (December 2022): 304–9. https://doi.org/10.1177/10892532221122666.Full Text Link to Item
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Dunkman, W Jonathan, Michael W. Manning, and David A. Williams. “Patterns of Use in Transesophageal Echocardiography for Liver Transplantation: A Systematic Review.” Semin Cardiothorac Vasc Anesth 26, no. 4 (December 2022): 274–81. https://doi.org/10.1177/10892532221133247.Full Text Link to Item
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Mamoun, Negmeldeen, Mary Cooter Wright, Brandi Bottiger, Ryan Plichta, Rebecca Klinger, Michael Manning, Karthik Raghunathan, and Padma Gulur. “Pain Trajectories After Valve Surgeries Performed via Midline Sternotomy Versus Mini-Thoracotomy.” J Cardiothorac Vasc Anesth 36, no. 9 (September 2022): 3596–3602. https://doi.org/10.1053/j.jvca.2022.05.007.Full Text Link to Item
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Maheshwari, Kamal, Gaurav Malhotra, Xiaodong Bao, Peiman Lahsaei, William R. Hand, Neal W. Fleming, Davinder Ramsingh, et al. “Assisted Fluid Management Software Guidance for Intraoperative Fluid Administration.” Anesthesiology 135, no. 2 (August 1, 2021): 273–83. https://doi.org/10.1097/ALN.0000000000003790.Full Text Open Access Copy Link to Item
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Barbas, Andrew S., Jacob N. Schroder, Deeplaxmi P. Borle, Arturo Suarez, Nader Abraham, Michael W. Manning, Timothy E. Miller, et al. “Planned Initiation of Venoarterial Extracorporeal Membrane Oxygenation Prior to Liver Transplantation in a Patient With Severe Portopulmonary Hypertension.” Liver Transpl 27, no. 5 (May 2021): 760–62. https://doi.org/10.1002/lt.25871.Full Text Link to Item
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Manning, Michael W., Yi-Ju Li, Dean Linder, John C. Haney, Yi-Hung Wu, Mihai V. Podgoreanu, Madhav Swaminathan, et al. “Conventional Ultrafiltration During Elective Cardiac Surgery and Postoperative Acute Kidney Injury.” J Cardiothorac Vasc Anesth 35, no. 5 (May 2021): 1310–18. https://doi.org/10.1053/j.jvca.2020.11.036.Full Text Link to Item
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Manning, Michael W., Priya A. Kumar, Kamal Maheshwari, and Harendra Arora. “Post-Reperfusion Syndrome in Liver Transplantation-An Overview.” J Cardiothorac Vasc Anesth 34, no. 2 (February 2020): 501–11. https://doi.org/10.1053/j.jvca.2019.02.050.Full Text Link to Item
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Gregory, Alexander J., Michael C. Grant, Michael W. Manning, Albert T. Cheung, Joerg Ender, Michael Sander, Alexander Zarbock, et al. “Enhanced Recovery After Cardiac Surgery (ERAS Cardiac) Recommendations: An Important First Step-But There Is Much Work to Be Done.” J Cardiothorac Vasc Anesth 34, no. 1 (January 2020): 39–47. https://doi.org/10.1053/j.jvca.2019.09.002.Full Text Link to Item
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Martin, Greg S., David A. Kaufman, Paul E. Marik, Nathan I. Shapiro, Denny Z. H. Levett, John Whittle, David B. MacLeod, et al. “Perioperative Quality Initiative (POQI) consensus statement on fundamental concepts in perioperative fluid management: fluid responsiveness and venous capacitance.” Perioper Med (Lond) 9 (2020): 12. https://doi.org/10.1186/s13741-020-00142-8.Full Text Open Access Copy Link to Item
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Dunkman, W Jonathan, Wendy Rycek, and Michael W. Manning. “What Does a Red Meat Allergy Have to Do With Anesthesia? Perioperative Management of Alpha-Gal Syndrome.” Anesth Analg 129, no. 5 (November 2019): 1242–48. https://doi.org/10.1213/ANE.0000000000003460.Full Text Link to Item
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Fierro, Michael A., Benjamin Dunne, David N. Ranney, Mani A. Daneshmand, John C. Haney, Jacob A. Klapper, Matthew G. Hartwig, Desiree Bonadonna, Michael W. Manning, and Raquel R. Bartz. “Perioperative Anesthetic and Transfusion Management of Veno-Venous Extracorporeal Membrane Oxygenation Patients Undergoing Noncardiac Surgery: A Case Series of 21 Procedures.” J Cardiothorac Vasc Anesth 33, no. 7 (July 2019): 1855–62. https://doi.org/10.1053/j.jvca.2019.01.055.Full Text Link to Item
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Suresh, Visakha, Muath Bishawi, Benjamin Bryner, Michael Manning, Chetan Patel, Carmelo Milano, Jacob Schroder, and Courtney Sommer. “Outcomes of Laparoscopic Cholecystectomy in Patients Supported with a Left Ventricular Assist Device.” J Laparoendosc Adv Surg Tech A 29, no. 4 (April 2019): 441–44. https://doi.org/10.1089/lap.2018.0431.Full Text Link to Item
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Herrera, Marcela, Ting Yang, Matthew A. Sparks, Michael W. Manning, Beverly H. Koller, and Thomas M. Coffman. “Complex Role for E-Prostanoid 4 Receptors in Hypertension.” J Am Heart Assoc 8, no. 4 (February 19, 2019): e010745. https://doi.org/10.1161/JAHA.118.010745.Full Text Open Access Copy Link to Item
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Dunkman, W Jonathan, Michael W. Manning, John Whittle, John Hunting, Edward N. Rampersaud, Brant A. Inman, Julie K. Thacker, and Timothy E. Miller. “Impact of an enhanced recovery pathway on length of stay and complications in elective radical cystectomy: a before and after cohort study.” Perioper Med (Lond) 8 (2019): 9. https://doi.org/10.1186/s13741-019-0120-4.Full Text Open Access Copy Link to Item
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Dunkman, W Jonathan, and Michael W. Manning. “Enhanced Recovery After Surgery and Multimodal Strategies for Analgesia.” Surg Clin North Am 98, no. 6 (December 2018): 1171–84. https://doi.org/10.1016/j.suc.2018.07.005.Full Text Link to Item
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Suresh, Visakha, Muath Bishawi, Michael W. Manning, Chetan Patel, Joseph Rogers, Carmelo Milano, Jacob Schroder, Mani Daneshmand, and David Powers. “Management of Patients With Left Ventricular Assist Devices Requiring Teeth Extraction: Is Halting Anticoagulation Appropriate?” J Oral Maxillofac Surg 76, no. 9 (September 2018): 1859–63. https://doi.org/10.1016/j.joms.2017.10.022.Full Text Link to Item
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Kolarczyk, Lavinia M., Harendra Arora, Michael W. Manning, David A. Zvara, and Robert S. Isaak. “Defining Value-Based Care in Cardiac and Vascular Anesthesiology: The Past, Present, and Future of Perioperative Cardiovascular Care.” J Cardiothorac Vasc Anesth 32, no. 1 (February 2018): 512–21. https://doi.org/10.1053/j.jvca.2017.09.043.Full Text Link to Item
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Koepke, Elena J., Erin L. Manning, Timothy E. Miller, Arun Ganesh, David G. A. Williams, and Michael W. Manning. “The rising tide of opioid use and abuse: the role of the anesthesiologist.” Perioper Med (Lond) 7 (2018): 16. https://doi.org/10.1186/s13741-018-0097-4.Full Text Open Access Copy Link to Item
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Williams, David G. A., Aaron J. Sandler, Elena Koepke, Erin L. Manning, Timothy E. Miller, and Michael W. Manning. “Fluid Management in the Elderly.” Current Anesthesiology Reports 7, no. 4 (December 2017): 357–63. https://doi.org/10.1007/s40140-017-0243-4.Full Text Open Access Copy
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Manning, Michael W., Chandrika R. Garner, and Emily G. Teeter. “Combining Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blocker for Clinical Decision-making Lacks Vision.” Anesthesiology 127, no. 4 (October 2017): 720–21. https://doi.org/10.1097/ALN.0000000000001801.Full Text Link to Item
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Manning, Michael W., William Jonathan Dunkman, and Timothy E. Miller. “Perioperative fluid and hemodynamic management within an enhanced recovery pathway.” J Surg Oncol 116, no. 5 (October 2017): 592–600. https://doi.org/10.1002/jso.24828.Full Text Open Access Copy Link to Item
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Karhausen, Jörn A., Alan M. Smeltz, Igor Akushevich, Mary Cooter, Mihai V. Podgoreanu, Mark Stafford-Smith, Susan M. Martinelli, Manuel L. Fontes, and Miklos D. Kertai. “Platelet Counts and Postoperative Stroke After Coronary Artery Bypass Grafting Surgery.” Anesth Analg 125, no. 4 (October 2017): 1129–39. https://doi.org/10.1213/ANE.0000000000002187.Full Text Open Access Copy Link to Item
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Manning, Michael W., Mary Cooter, Joseph Mathew, John Alexander, Eric Peterson, T Bruce Ferguson, Renato Lopes, and Mihai Podgoreanu. “Angiotensin Receptor Blockade Improves Cardiac Surgical Outcomes in Patients With Metabolic Syndrome.” Ann Thorac Surg 104, no. 1 (July 2017): 98–105. https://doi.org/10.1016/j.athoracsur.2016.10.021.Full Text Link to Item
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Urbas, Aaron, Michael W. Manning, Alan Daugherty, Lisa A. Cassis, and Robert A. Lodder. “Near-infrared spectrometry of abdominal aortic aneurysm in the ApoE-/- mouse.” Anal Chem 75, no. 14 (July 15, 2003): 3650–55. https://doi.org/10.1021/ac034113n.Full Text Link to Item
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Manning, Michael W., Lisa A. Cassis, and Alan Daugherty. “Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms.” Arterioscler Thromb Vasc Biol 23, no. 3 (March 1, 2003): 483–88. https://doi.org/10.1161/01.ATV.0000058404.92759.32.Full Text Link to Item
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Manning, Michael W., Lisa A. Cassi, Jing Huang, Stephen J. Szilvassy, and Alan Daugherty. “Abdominal aortic aneurysms: fresh insights from a novel animal model of the disease.” Vasc Med 7, no. 1 (February 2002): 45–54. https://doi.org/10.1191/1358863x02vm413ra.Full Text Link to Item
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Daugherty, A., M. W. Manning, and L. A. Cassis. “Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis.” Br J Pharmacol 134, no. 4 (October 2001): 865–70. https://doi.org/10.1038/sj.bjp.0704331.Full Text Link to Item
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Cass, W. A., M. W. Manning, and S. L. Bailey. “Restorative effects of GDNF on striatal dopamine release in rats treated with neurotoxic doses of methamphetamine.” Ann N Y Acad Sci 914 (September 2000): 127–36. https://doi.org/10.1111/j.1749-6632.2000.tb05190.x.Full Text Link to Item
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Daugherty, A., M. W. Manning, and L. A. Cassis. “Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice.” J Clin Invest 105, no. 11 (June 2000): 1605–12. https://doi.org/10.1172/JCI7818.Full Text Link to Item
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Cass, W. A., and M. W. Manning. “Recovery of presynaptic dopaminergic functioning in rats treated with neurotoxic doses of methamphetamine.” J Neurosci 19, no. 17 (September 1, 1999): 7653–60. https://doi.org/10.1523/JNEUROSCI.19-17-07653.1999.Full Text Link to Item
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Cass, W. A., D. J. Walker, and M. W. Manning. “Augmented methamphetamine-induced overflow of striatal dopamine 1 day after GDNF administration.” Brain Res 827, no. 1–2 (May 8, 1999): 104–12. https://doi.org/10.1016/s0006-8993(99)01314-1.Full Text Link to Item
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Cass, W. A., and M. W. Manning. “GDNF protection against 6-OHDA-induced reductions in potassium-evoked overflow of striatal dopamine.” J Neurosci 19, no. 4 (February 15, 1999): 1416–23. https://doi.org/10.1523/JNEUROSCI.19-04-01416.1999.Full Text Link to Item
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Cass, W. A., M. W. Manning, and M. T. Dugan. “Effects of neurotoxic doses of methamphetamine on potassium and amphetamine evoked overflow of dopamine in the striatum of awake rats.” Neurosci Lett 248, no. 3 (June 5, 1998): 175–78. https://doi.org/10.1016/s0304-3940(98)00374-7.Full Text Link to Item
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Conference Papers
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Boom, Willem van den, Rebecca A. Schroeder, Michael W. Manning, Tracy L. Setji, Gic-Owens Fiestan, and David B. Dunson. “Effect of A1C and Glucose on Postoperative Mortality in Noncardiac and Cardiac Surgeries.” In Diabetes Care, 41:782–88, 2018. https://doi.org/10.2337/dc17-2232.Full Text Link to Item
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Manning, Michael, Yi-Ju Li, Dean Linder, John Haney, Yi-Hung Wu, Mihai Podgoreanu, Jacob Schroder, et al. “Ultrafiltration on CPB Predicts AKI and Transfusion.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.Link to Item
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Sigurdsson, Martin I., Nathan H. Waldron, Michael W. Manning, Quintin J. Quinones, Joseph P. Mathew, and Mihai V. Podgoreanu. “Genomic Classification of Permanent versus New-onset Postoperative Atrial Fibrillation Using Atrial Myocardial Gene Expression Profiling.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.Link to Item
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Yang, Ting, Marcela Herrera, Matthew A. Sparks, Michael Manning, Beverly H. Koller, and Thomas M. Coffman. “Unexpected Actions of the Endothelial-EP4 Receptor for PGE(2) to Promote Hypertension.” In Hypertension, Vol. 68. LIPPINCOTT WILLIAMS & WILKINS, 2016.Link to Item
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Manning, M. W., L. A. Cassis, and A. Daugherty. “The matrix metalloproteinase inhibitor doxycycline reduces the incidence and severity of angiotensin II-induced aortic aneurysms.” In Arteriosclerosis Thrombosis and Vascular Biology, 22:A70–A70. LIPPINCOTT WILLIAMS & WILKINS, 2002.Link to Item
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Manning, M. W., S. J. Szilvassy, L. A. Cassis, and A. Daugherty. “Angiotensin AT1a receptors on bone marrow derived cells are critical for angiotensin II-induced aneurysm formation and progression of atherosclerosis.” In Arteriosclerosis Thrombosis and Vascular Biology, 21:711–711. LIPPINCOTT WILLIAMS & WILKINS, 2001.Link to Item
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Cass, W. A., and M. W. Manning. “GDNF protection against 6-OHDA-induced reductions in evoked overflow of dopamine in the striatum.” In Experimental Neurology, 153:387–88. ACADEMIC PRESS INC, 1998.Link to Item
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- Scholarly, Clinical, & Service Activities
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Service to Duke
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Clinical Activities
- Faculty anesthesiologist caring for patients undergoing high risk non-cardiac surgery, cardiac surgery, and heart/lung/liver/kidney/intestinal transplants.
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