Michael Wayne Manning | Scholars@Duke

Michael Wayne Manning
Associate Professor of Anesthesiology

Dr. Michael W. Manning, MD, PhD, is currently an Associate Professor at Duke University Medical Center, within the Divisions of Cardiothoracic and General, Vascular, Transplant anesthesia. He serves as the director of research for the Perioperative Medicine Fellowship at Duke. His clinical practice focuses on high risk cardiac surgery, Heart, Lung, and Liver transplantation.

Dr. Manning earned a PhD in cardiovascular physiology from the University of Kentucky where studied the role that Angiotensin II mediated inflammation plays in the development of abdominal aortic aneurysms. After graduate school, Dr. Manning remained at the University of Kentucky earning his MD degree. He completed a year of general surgery residency, before switching to anesthesia. Following residency, Dr.
Manning continued his clinical training at Duke University with a one-year clinical fellowship in Adult Cardiothoracic Anesthesiology and a 2-year research fellowship. He joined the Duke faculty in 2014.

His current research interests are ERAS centered, specifically in the areas of role of opioid-free anesthesia as well as goal directed fluid therapy in cardiac surgery on renal outcomes.

Office Hours

Wednesday 3pm - 5pm
Friday 3pm-5pm

Current Appointments & Affiliations

Associate Professor of Anesthesiology, Anesthesiology, General, Vascular, High Risk Transplant & Critical Care, Anesthesiology 2021

Contact Information

michael.manning@duke.edu

Background
Education, Training, & Certifications
- M.D., University of Kentucky, College of Medicine 2006
Medical Licensure
- 172242. North Carolina. 2020
- 43498. Kentucky. 2020
Previous Appointments & Affiliations
- Assistant Professor of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2021
- Assistant Professor of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2014 - 2020
- Medical Instructor in the Department of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2012 - 2014
Research
Selected Grants
- Acute Inflammation, Fibrosis in Post Operative Atrial Fibrillation awarded by International Anesthesia Research Society 2015 - 2017
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Mamoun, Negmeldeen, Mary Cooter Wright, Brandi Bottiger, Ryan Plichta, Rebecca Klinger, Michael Manning, Karthik Raghunathan, and Padma Gulur. “Pain Trajectories After Valve Surgeries Performed via Midline Sternotomy Versus Mini-Thoracotomy.” J Cardiothorac Vasc Anesth, May 10, 2022. https://doi.org/10.1053/j.jvca.2022.05.007.
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  - Maheshwari, Kamal, Gaurav Malhotra, Xiaodong Bao, Peiman Lahsaei, William R. Hand, Neal W. Fleming, Davinder Ramsingh, et al. “Assisted Fluid Management Software Guidance for Intraoperative Fluid Administration.” Anesthesiology 135, no. 2 (August 1, 2021): 273–83. https://doi.org/10.1097/ALN.0000000000003790.
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  - Barbas, Andrew S., Jacob N. Schroder, Deeplaxmi P. Borle, Arturo Suarez, Nader Abraham, Michael W. Manning, Timothy E. Miller, et al. “Planned Initiation of Venoarterial Extracorporeal Membrane Oxygenation Prior to Liver Transplantation in a Patient With Severe Portopulmonary Hypertension.” Liver Transpl 27, no. 5 (May 2021): 760–62. https://doi.org/10.1002/lt.25871.
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  - Manning, Michael W., Yi-Ju Li, Dean Linder, John C. Haney, Yi-Hung Wu, Mihai V. Podgoreanu, Madhav Swaminathan, et al. “Conventional Ultrafiltration During Elective Cardiac Surgery and Postoperative Acute Kidney Injury.” J Cardiothorac Vasc Anesth 35, no. 5 (May 2021): 1310–18. https://doi.org/10.1053/j.jvca.2020.11.036.
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  - Manning, Michael W., Priya A. Kumar, Kamal Maheshwari, and Harendra Arora. “Post-Reperfusion Syndrome in Liver Transplantation-An Overview.” J Cardiothorac Vasc Anesth 34, no. 2 (February 2020): 501–11. https://doi.org/10.1053/j.jvca.2019.02.050.
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  - Gregory, Alexander J., Michael C. Grant, Michael W. Manning, Albert T. Cheung, Joerg Ender, Michael Sander, Alexander Zarbock, et al. “Enhanced Recovery After Cardiac Surgery (ERAS Cardiac) Recommendations: An Important First Step-But There Is Much Work to Be Done.” J Cardiothorac Vasc Anesth 34, no. 1 (January 2020): 39–47. https://doi.org/10.1053/j.jvca.2019.09.002.
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  - Martin, Greg S., David A. Kaufman, Paul E. Marik, Nathan I. Shapiro, Denny Z. H. Levett, John Whittle, David B. MacLeod, et al. “Perioperative Quality Initiative (POQI) consensus statement on fundamental concepts in perioperative fluid management: fluid responsiveness and venous capacitance.” Perioper Med (Lond) 9 (2020): 12. https://doi.org/10.1186/s13741-020-00142-8.
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  - Dunkman, W Jonathan, Wendy Rycek, and Michael W. Manning. “What Does a Red Meat Allergy Have to Do With Anesthesia? Perioperative Management of Alpha-Gal Syndrome.” Anesth Analg 129, no. 5 (November 2019): 1242–48. https://doi.org/10.1213/ANE.0000000000003460.
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  - Fierro, Michael A., Benjamin Dunne, David N. Ranney, Mani A. Daneshmand, John C. Haney, Jacob A. Klapper, Matthew G. Hartwig, Desiree Bonadonna, Michael W. Manning, and Raquel R. Bartz. “Perioperative Anesthetic and Transfusion Management of Veno-Venous Extracorporeal Membrane Oxygenation Patients Undergoing Noncardiac Surgery: A Case Series of 21 Procedures.” J Cardiothorac Vasc Anesth 33, no. 7 (July 2019): 1855–62. https://doi.org/10.1053/j.jvca.2019.01.055.
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  - Suresh, Visakha, Muath Bishawi, Benjamin Bryner, Michael Manning, Chetan Patel, Carmelo Milano, Jacob Schroder, and Courtney Sommer. “Outcomes of Laparoscopic Cholecystectomy in Patients Supported with a Left Ventricular Assist Device.” J Laparoendosc Adv Surg Tech A 29, no. 4 (April 2019): 441–44. https://doi.org/10.1089/lap.2018.0431.
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  - Herrera, Marcela, Ting Yang, Matthew A. Sparks, Michael W. Manning, Beverly H. Koller, and Thomas M. Coffman. “Complex Role for E-Prostanoid 4 Receptors in Hypertension.” J Am Heart Assoc 8, no. 4 (February 19, 2019): e010745. https://doi.org/10.1161/JAHA.118.010745.
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  - Dunkman, W Jonathan, Michael W. Manning, John Whittle, John Hunting, Edward N. Rampersaud, Brant A. Inman, Julie K. Thacker, and Timothy E. Miller. “Impact of an enhanced recovery pathway on length of stay and complications in elective radical cystectomy: a before and after cohort study.” Perioper Med (Lond) 8 (2019): 9. https://doi.org/10.1186/s13741-019-0120-4.
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  - Dunkman, W Jonathan, and Michael W. Manning. “Enhanced Recovery After Surgery and Multimodal Strategies for Analgesia.” Surg Clin North Am 98, no. 6 (December 2018): 1171–84. https://doi.org/10.1016/j.suc.2018.07.005.
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  - Suresh, Visakha, Muath Bishawi, Michael W. Manning, Chetan Patel, Joseph Rogers, Carmelo Milano, Jacob Schroder, Mani Daneshmand, and David Powers. “Management of Patients With Left Ventricular Assist Devices Requiring Teeth Extraction: Is Halting Anticoagulation Appropriate?” J Oral Maxillofac Surg 76, no. 9 (September 2018): 1859–63. https://doi.org/10.1016/j.joms.2017.10.022.
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  - Kolarczyk, Lavinia M., Harendra Arora, Michael W. Manning, David A. Zvara, and Robert S. Isaak. “Defining Value-Based Care in Cardiac and Vascular Anesthesiology: The Past, Present, and Future of Perioperative Cardiovascular Care.” J Cardiothorac Vasc Anesth 32, no. 1 (February 2018): 512–21. https://doi.org/10.1053/j.jvca.2017.09.043.
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  - Koepke, Elena J., Erin L. Manning, Timothy E. Miller, Arun Ganesh, David G. A. Williams, and Michael W. Manning. “The rising tide of opioid use and abuse: the role of the anesthesiologist.” Perioper Med (Lond) 7 (2018): 16. https://doi.org/10.1186/s13741-018-0097-4.
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  - Williams, David G. A., Aaron J. Sandler, Elena Koepke, Erin L. Manning, Timothy E. Miller, and Michael W. Manning. “Fluid Management in the Elderly.” Current Anesthesiology Reports 7, no. 4 (December 2017): 357–63. https://doi.org/10.1007/s40140-017-0243-4.
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  - Manning, Michael W., Chandrika R. Garner, and Emily G. Teeter. “Combining Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blocker for Clinical Decision-making Lacks Vision.” Anesthesiology 127, no. 4 (October 2017): 720–21. https://doi.org/10.1097/ALN.0000000000001801.
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  - Manning, Michael W., William Jonathan Dunkman, and Timothy E. Miller. “Perioperative fluid and hemodynamic management within an enhanced recovery pathway.” J Surg Oncol 116, no. 5 (October 2017): 592–600. https://doi.org/10.1002/jso.24828.
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  - Karhausen, Jörn A., Alan M. Smeltz, Igor Akushevich, Mary Cooter, Mihai V. Podgoreanu, Mark Stafford-Smith, Susan M. Martinelli, Manuel L. Fontes, and Miklos D. Kertai. “Platelet Counts and Postoperative Stroke After Coronary Artery Bypass Grafting Surgery.” Anesth Analg 125, no. 4 (October 2017): 1129–39. https://doi.org/10.1213/ANE.0000000000002187.
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  - Manning, Michael W., Mary Cooter, Joseph Mathew, John Alexander, Eric Peterson, T Bruce Ferguson, Renato Lopes, and Mihai Podgoreanu. “Angiotensin Receptor Blockade Improves Cardiac Surgical Outcomes in Patients With Metabolic Syndrome.” Ann Thorac Surg 104, no. 1 (July 2017): 98–105. https://doi.org/10.1016/j.athoracsur.2016.10.021.
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  - Urbas, Aaron, Michael W. Manning, Alan Daugherty, Lisa A. Cassis, and Robert A. Lodder. “Near-infrared spectrometry of abdominal aortic aneurysm in the ApoE-/- mouse.” Anal Chem 75, no. 14 (July 15, 2003): 3650–55. https://doi.org/10.1021/ac034113n.
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  - Manning, Michael W., Lisa A. Cassis, and Alan Daugherty. “Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms.” Arterioscler Thromb Vasc Biol 23, no. 3 (March 1, 2003): 483–88. https://doi.org/10.1161/01.ATV.0000058404.92759.32.
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  - Manning, Michael W., Lisa A. Cassi, Jing Huang, Stephen J. Szilvassy, and Alan Daugherty. “Abdominal aortic aneurysms: fresh insights from a novel animal model of the disease.” Vasc Med 7, no. 1 (February 2002): 45–54. https://doi.org/10.1191/1358863x02vm413ra.
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  - Daugherty, A., M. W. Manning, and L. A. Cassis. “Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis.” Br J Pharmacol 134, no. 4 (October 2001): 865–70. https://doi.org/10.1038/sj.bjp.0704331.
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  - Cass, W. A., M. W. Manning, and S. L. Bailey. “Restorative effects of GDNF on striatal dopamine release in rats treated with neurotoxic doses of methamphetamine.” Ann N Y Acad Sci 914 (September 2000): 127–36. https://doi.org/10.1111/j.1749-6632.2000.tb05190.x.
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  - Daugherty, A., M. W. Manning, and L. A. Cassis. “Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice.” J Clin Invest 105, no. 11 (June 2000): 1605–12. https://doi.org/10.1172/JCI7818.
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  - Cass, W. A., and M. W. Manning. “Recovery of presynaptic dopaminergic functioning in rats treated with neurotoxic doses of methamphetamine.” J Neurosci 19, no. 17 (September 1, 1999): 7653–60.
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  - Cass, W. A., D. J. Walker, and M. W. Manning. “Augmented methamphetamine-induced overflow of striatal dopamine 1 day after GDNF administration.” Brain Res 827, no. 1–2 (May 8, 1999): 104–12. https://doi.org/10.1016/s0006-8993(99)01314-1.
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  - Cass, W. A., and M. W. Manning. “GDNF protection against 6-OHDA-induced reductions in potassium-evoked overflow of striatal dopamine.” J Neurosci 19, no. 4 (February 15, 1999): 1416–23.
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  - Cass, W. A., M. W. Manning, and M. T. Dugan. “Effects of neurotoxic doses of methamphetamine on potassium and amphetamine evoked overflow of dopamine in the striatum of awake rats.” Neurosci Lett 248, no. 3 (June 5, 1998): 175–78. https://doi.org/10.1016/s0304-3940(98)00374-7.
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- Conference Papers
  - Boom, Willem van den, Rebecca A. Schroeder, Michael W. Manning, Tracy L. Setji, Gic-Owens Fiestan, and David B. Dunson. “Effect of A1C and Glucose on Postoperative Mortality in Noncardiac and Cardiac Surgeries.” In Diabetes Care, 41:782–88, 2018. https://doi.org/10.2337/dc17-2232.
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  - Manning, Michael, Yi-Ju Li, Dean Linder, John Haney, Yi-Hung Wu, Mihai Podgoreanu, Jacob Schroder, et al. “Ultrafiltration on CPB Predicts AKI and Transfusion.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.
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  - Sigurdsson, Martin I., Nathan H. Waldron, Michael W. Manning, Quintin J. Quinones, Joseph P. Mathew, and Mihai V. Podgoreanu. “Genomic Classification of Permanent versus New-onset Postoperative Atrial Fibrillation Using Atrial Myocardial Gene Expression Profiling.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.
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  - Yang, Ting, Marcela Herrera, Matthew A. Sparks, Michael Manning, Beverly H. Koller, and Thomas M. Coffman. “Unexpected Actions of the Endothelial-EP4 Receptor for PGE(2) to Promote Hypertension.” In Hypertension, Vol. 68. LIPPINCOTT WILLIAMS & WILKINS, 2016.
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  - Manning, M. W., L. A. Cassis, and A. Daugherty. “The matrix metalloproteinase inhibitor doxycycline reduces the incidence and severity of angiotensin II-induced aortic aneurysms.” In Arteriosclerosis Thrombosis and Vascular Biology, 22:A70–A70. LIPPINCOTT WILLIAMS & WILKINS, 2002.
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  - Manning, M. W., S. J. Szilvassy, L. A. Cassis, and A. Daugherty. “Angiotensin AT1a receptors on bone marrow derived cells are critical for angiotensin II-induced aneurysm formation and progression of atherosclerosis.” In Arteriosclerosis Thrombosis and Vascular Biology, 21:711–711. LIPPINCOTT WILLIAMS & WILKINS, 2001.
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  - Cass, W. A., and M. W. Manning. “GDNF protection against 6-OHDA-induced reductions in evoked overflow of dopamine in the striatum.” In Experimental Neurology, 153:387–88. ACADEMIC PRESS INC, 1998.
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Scholarly, Clinical, & Service Activities
Service to Duke
- Institutional Review Board. August 2020 2020
Clinical Activities
- Faculty anesthesiologist caring for patients undergoing high risk non-cardiac surgery, cardiac surgery, and heart/lung/liver/kidney/intestinal transplants.

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Education, Training, & Certifications

Medical Licensure

Previous Appointments & Affiliations

Selected Grants

Selected Publications

Academic Articles

Conference Papers

Service to Duke

Clinical Activities