Overview
Dr. Michael W. Manning, MD, Ph.D., is an Associate Professor at Duke University Medical Center, within the Divisions of Cardiothoracic and General, Vascular, and Transplant anesthesia. He serves as the director of Enhanced Recovery after Surgery programs and the director of research for the Perioperative Medicine Fellowship at Duke. His clinical practice focuses on high-risk cardiac surgery, Heart, Lung, and Liver transplantation.
Dr. Manning earned a Ph.D. in cardiovascular physiology from the University of Kentucky, where he studied the role of Angiotensin II-mediated inflammation in the development of abdominal aortic aneurysms. After graduate school, Dr. Manning remained at the University of Kentucky, earning his MD degree. He completed a year of general surgery residency before switching to anesthesia. Following residency, Dr.
Manning continued his clinical training at Duke University with a one-year clinical fellowship in Adult Cardiothoracic Anesthesiology and a 2-year research fellowship. He joined the Duke faculty in 2014.
His current research interests are ERAS centered, specifically in the role of opioid-free anesthesia and goal-directed fluid therapy in cardiac surgery on renal outcomes.
Current Appointments & Affiliations
Recent Publications
Pain Trajectories After Cardiac Surgery Performed Via Midline Sternotomy.
Journal Article J Cardiothorac Vasc Anesth · December 2025 OBJECTIVES: Acute pain after cardiac surgery performed via midline sternotomy is reported to be moderate to severe in intensity in up to three-quarters of patients in the early postoperative period. This work was designed to describe different pain traject ... Full text Link to item CiteHow We Would Use Enhanced Recovery After Cardiac Surgery: What We Would Do for Ourselves During the Perioperative Period.
Journal Article J Cardiothorac Vasc Anesth · August 2025 Enhanced Recovery After Cardiac Surgery (ERACS) programs have grown from their humble beginnings as a "fast-track recovery" pathway that was first described in 1994 and have now evolved into patient-centered, multidisciplinary, multimodal, comprehensive, e ... Full text Link to item CiteERAS/STS 2024 Expert Consensus Statement on Perioperative Care in Cardiac Surgery: Continuing the Evolution of Optimized Patient Care and Recovery.
Journal Article J Cardiothorac Vasc Anesth · October 2024 Full text Open Access Link to item CiteRecent Grants
The Choice of Vasopressors to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery (VEGA-2)
ResearchPrincipal Investigator · Awarded by University of California - San Francisco · 2025 - 2026A PHASE II, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF THE EFFICACY AND SAFETY OF GDC-8264 IN PREVENTING CARDIAC SURGERY-ASSOCIATED ACUTE KIDNEY INJURY AND MAJOR ADVERSE KIDNEY EVENTS
Clinical TrialPrincipal Investigator · Awarded by Genentech, Inc. · 2024 - 2026Acute Inflammation, Fibrosis in Post Operative Atrial Fibrillation
ResearchPrincipal Investigator · Awarded by International Anesthesia Research Society · 2015 - 2017View All Grants