Scholars@Duke
Michael B Rothberg

Michael B Rothberg

Assistant Professor of Urology
Urology

Selected Publications

Genetic ancestry concordant RNA splicing in prostate cancer involves oncogenic genes and associates with recurrence.

Journal Article NPJ Precis Oncol · January 29, 2025 Black men suffer disproportionately from prostate cancer (PCa) compared to men of other races and ethnicities. Comparing the molecular landscape of PCa among Black and White patients has the potential to identify targets for development of new precision me ... Full text Link to item Cite

Staging Imaging for Focal Therapy of Prostate Cancer

Chapter · January 1, 2025 Contemporary prostate imaging modalities serve a complementary role to the medical history, physical examination, serum prostate-specific antigen (PSA) levels, and prostate biopsy pathology in performing a complete staging work-up for localized prostate ca ... Full text Cite

Realistic digital phantoms for prostate ultrasound and photoacoustic imaging

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2024 In this work, we introduce the first realistic digital phantoms for prostate ultrasound and photoacoustic (PA) imaging in the male pelvic region. Our model encompasses surrounding tissues or organs around the prostate, including fat, bones (including femor ... Full text Cite

Is prostatic adenocarcinoma with cribriform architecture more difficult to detect on prostate MRI?

Journal Article Prostate · December 2023 BACKGROUND: Cribriform (CBFM) pattern on prostate biopsy has been implicated as a predictor for high-risk features, potentially leading to adverse outcomes after definitive treatment. This study aims to investigate whether the CBFM pattern containing prost ... Full text Link to item Cite

A Novel Magnetic Resonance Imaging/Ultrasound Fusion Prostate Biopsy Technique Using Transperineal Ultrasound: An Initial Experience.

Journal Article Urology · November 2023 OBJECTIVE: To report an initial experience with a novel, "fully" transperineal (TP) prostate fusion biopsy using an unconstrained ultrasound transducer placed on the perineal skin to guide biopsy needles inserted via a TP approach. METHODS: Conventional TP ... Full text Link to item Cite

The role of novel imaging in prostate cancer focal therapy: treatment and follow-up.

Journal Article Curr Opin Urol · May 1, 2022 PURPOSE OF REVIEW: Multiparametric magnetic resonance imaging (mpMRI) has fundamentally changed how intraprostatic lesions are visualized, serving as a highly sensitive means for detecting clinically significant prostate cancer (csPCa) via image-targeted b ... Full text Link to item Cite

Long-term oncologic outcomes of positive surgical margins following robot-assisted partial nephrectomy

Journal Article Translational Andrology and Urology · April 1, 2020 Background: Previous reports on positive surgical margin (PSM) after robot-assisted partial nephrectomy (RAPN) have reached inconsistent conclusions as to the impact of a PSM on oncologic outcomes. We sought to determine the effect of PSM on long-term canc ... Full text Cite

A Multi-Institutional Analysis of the Effect of Positive Surgical Margins Following Robot-Assisted Partial Nephrectomy on Oncologic Outcomes.

Journal Article J Endourol · March 2020 Objective: To determine the effect of positive surgical margins (PSMs) on oncologic outcomes following robot-assisted partial nephrectomy (RAPN) and to identify factors that increase the likelihood of adverse oncologic outcomes. Methods: A multi-institutio ... Full text Link to item Cite

Management of high complexity renal masses in partial nephrectomy: A multicenter analysis.

Journal Article Urol Oncol · July 2019 OBJECTIVE: To determine the safety and efficacy of performing partial nephrectomy (PN) on patients with high nephrometry score tumors. PATIENTS AND METHODS: We used a prospectively maintained multi-institutional kidney cancer database to identify 144 patie ... Full text Link to item Cite

Protein kinase D1 induces G1-phase cell-cycle arrest independent of Checkpoint kinases by phosphorylating Cell Division Cycle Phosphatase 25.

Journal Article Prostate · June 2019 Protein Kinase D1 (PrKD1) functions as a tumor and metastasis suppressor in several human cancers by influencing cell-cycle progression. However, the exact mechanism of cell-cycle regulation by PrKD1 is unclear. Overexpression and ectopic expression of PrK ... Full text Link to item Cite

A National Cancer Database-based nomogram to predict lymph node metastasis in penile cancer.

Journal Article BJU Int · June 2019 OBJECTIVE: To evaluate the predictive nature of several clinicopathological variables by developing a nomogram predictive for lymph node-positive disease using the National Cancer Database cohort of patients with squamous cell carcinoma of the penis. METHO ... Full text Link to item Cite

Beta-catenin represses protein kinase D1 gene expression by non-canonical pathway through MYC/MAX transcription complex in prostate cancer.

Journal Article Oncotarget · October 3, 2017 Down regulation of Protein Kinase D1 (PrKD1), a novel serine threonine kinase, in prostate, gastric, breast and colon cancers in humans leads to disease progression. While the down regulation of PrKD1 by DNA methylation in gastric cancer and by nuclear bet ... Full text Link to item Cite

Comparative Analysis of Renal Functional Outcomes and Overall Survival of Elderly vs Nonelderly Patients Undergoing Radical Nephrectomy.

Journal Article J Endourol · February 2017 PURPOSE: To evaluate changes in renal function and overall survival in elderly vs nonelderly patients undergoing radical nephrectomy (RN) for renal masses. PATIENTS AND METHODS: We reviewed available records of 392 patients undergoing RN from 2008 through ... Full text Link to item Cite

Prospective Correlation between Likelihood of Favorable Pathology on the 17-Gene Genomic Prostate Score and Actual Pathological Outcomes at Radical Prostatectomy

Journal Article Urology Practice · September 1, 2016 Introduction We evaluate the Genomic Prostate Score in a prospective clinical setting and determine the cutoff point for likelihood of favorable pathology, below which definitive treatment should be advised. Methods Pathological data were recorded for men ... Full text Cite

Predictors of biochemical recurrence in pT3b prostate cancer after radical prostatectomy without adjuvant radiotherapy.

Journal Article Prostate · February 2016 BACKGROUND: Men with pathologic evidence of seminal vesicle invasion (SVI) at radical prostatectomy (RP) have higher rates of biochemical recurrence (BCR) and mortality. Adjuvant radiotherapy (XRT) has been shown to increase freedom from BCR, but its impac ... Full text Link to item Cite

Close surgical margins after radical prostatectomy mimic biochemical recurrence rates of positive margins.

Journal Article Urol Oncol · November 2015 INTRODUCTION: The significance of a "close" but negative surgical margin after radical prostatectomy (RP) is controversial. We evaluated the effect of a close surgical margin (CSM) on biochemical recurrence (BCR) compared to a negative margin after RP. MAT ... Full text Link to item Cite

Comparison of Renal Parenchymal Volume Preservation Between Partial Nephrectomy, Cryoablation, and Radiofrequency Ablation Using 3D Volume Measurements.

Journal Article J Endourol · August 2015 PURPOSE: Small renal masses (SRM) can be managed via a variety of nephron-sparing procedures (NSPs), but the association between choice of NSP and renal parenchymal volume (RPV) preservation is not well understood. We sought to examine RPV preservation aft ... Full text Link to item Cite

The Impact of a Biopsy Based 17-Gene Genomic Prostate Score on Treatment Recommendations in Men with Newly Diagnosed Clinically Prostate Cancer Who are Candidates for Active Surveillance

Journal Article Urology Practice · July 1, 2015 Introduction: The biopsy based 17-gene GPS was clinically validated to predict the likelihood of adverse surgical pathology in men with NCCN® very low, low or low-intermediate risk prostate cancer. We performed a prospective study to assess the ... Full text Cite

Increasing volume of non-neoplastic parenchyma in partial nephrectomy specimens is associated with chronic kidney disease upstaging.

Journal Article Clin Genitourin Cancer · June 2015 INTRODUCTION: We examined the effect of non-neoplastic parenchymal volumes (NNPVs) in partial nephrectomy (PN) surgical specimens on long-term postoperative renal function. PN for renal cortical neoplasms has demonstrated superior long-term renal function ... Full text Link to item Cite

Primary renal mesenchymal chondrosarcoma: a case report.

Journal Article Urology · March 2015 A 16-year-old female patient presented to our emergency department with a left upper extremity radiculopathy prompting several imaging studies. Magnetic resonance imaging of the neck revealed multiple cervical vertebrae lesions and computed tomography imag ... Full text Link to item Cite

Synergism between metformin and statins in modifying the risk of biochemical recurrence following radical prostatectomy in men with diabetes.

Journal Article Prostate Cancer Prostatic Dis · March 2015 BACKGROUND: To determine the effect of statins and metformin in combination on biochemical recurrence (BCR) among diabetic men undergoing radical prostatectomy (RP). METHODS: Diabetic men undergoing RP at our institution from January 1995 to March 2012 wer ... Full text Link to item Cite

Baseline serum 25-hydroxyvitamin d levels in men undergoing radical prostatectomy: is there an association with adverse pathologic features?

Journal Article Clin Genitourin Cancer · October 2014 INTRODUCTION/BACKGROUND: The purpose of this study was to evaluate the prevalence of vitamin D (VitD) deficiency in men undergoing radical prostatectomy and determine whether an association exists between preoperative VitD levels and adverse pathologic fea ... Full text Link to item Cite

Robot-assisted nephroureterectomy and bladder cuff excision without patient or robot repositioning: description of modified port placement and technique.

Journal Article J Laparoendosc Adv Surg Tech A · September 2014 INTRODUCTION: Nephroureterectomy (NUx) with full bladder cuff excision is the gold-standard treatment for upper urinary tract urothelial cancer. Although minimally invasive techniques for NUx have demonstrated comparable outcomes to those of the open techn ... Full text Link to item Cite

Lumbar artery branch injury secondary to ureteroscopic manipulation

Journal Article Canadian Urological Association Journal · May 1, 2014 Iatrogenic vascular injury in ureteroscopy is relatively uncommon and typically presents as a subcapsular hematoma. We report the case of an injury to a branch of the lumbar artery secondary to ureteral trauma during ureteroscopy. In the immediate postoper ... Full text Cite

The da vinci robot system eliminates multispecialty surgical trainees' hand dominance in open and robotic surgical settings.

Journal Article JSLS · 2014 BACKGROUND AND OBJECTIVES: Handedness, or the inherent dominance of one hand's dexterity over the other's, is a factor in open surgery but has an unknown importance in robot-assisted surgery. We sought to examine whether the robotic surgery platform could ... Full text Link to item Cite

Contemporary experience with laparoscopic radical nephrectomy.

Journal Article J Laparoendosc Adv Surg Tech A · 2011 INTRODUCTION: We present our single-center contemporary experience with laparoscopic radical nephrectomy (LRN). LRN is an established minimally invasive approach comparable to open radical nephrectomy for the treatment of renal cortical neoplasms. Technica ... Full text Link to item Cite

Intrarenal pressures generated during deployment of various antiretropulsion devices in an ex vivo porcine model.

Journal Article J Endourol · July 2010 INTRODUCTION: Pressurized saline irrigation is commonly used during ureteroscopy, which can cause an increase in intrarenal pressure leading to postoperative pain, sepsis, and renal injury due to pyelovenous and pyelolymphatic backflow. To prevent retrogra ... Full text Link to item Cite

Robot-assisted radical cystoprostatectomy in complex surgical patients: single institution report.

Journal Article Can J Urol · June 2009 OBJECTIVE: To evaluate the safety and feasibility of robotic-assisted radical cystoprostatectomy (RRCP) in a salvage setting for patients with a history of radiation and chemotherapy treatment, complex pelvic anatomy, and significant comorbidities. MATERIA ... Link to item Cite