Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Resident, Internal Medicine, University of Texas Southwestern Medical Center at Dallas Southwestern Medical School 2004 - 2007
  • M.D., Columbia University 2004
• 

  Duke Appointment History

  • Medical Instructor in the Department of Medicine, Medicine, Cardiology, Medicine 2012 - 2013
• Research
• 

  Selected Grants

  • Attract Extension awarded by Pfizer, Inc. 2016 - 2021
  • DEF 314 Lantheus awarded by Lantheus Medical Imaging 2018 - 2019
  • ISCHEMIA-CKD awarded by New York University School of Medicine 2014 - 2019
  • EXCITE awarded by Sloan Kettering Institute 2018
  • CIAO ISCHEMIA awarded by New York University School of Medicine 2014 - 2018
  • SCUSF 0806 Phase II placebo--controlled trial of lisinopril and Coreg awarded by University of South Florida 2013 - 2014
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Khouri, MG, Ky, B, Dunn, G, Plappert, T, Englefield, V, Rabineau, D, Yow, E, Barnhart, HX, St John Sutton, M, and Douglas, PS. "Echocardiography Core Laboratory Reproducibility of Cardiac Safety Assessments in Cardio-Oncology." Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography 31, no. 3 (March 2018): 361-371.e3.  Full Text
    • Armenian, SH, Ryan, TD, and Khouri, MG. "Cardiac Dysfunction and Heart Failure in Hematopoietic Cell Transplantation Survivors: Emerging Paradigms in Pathophysiology, Screening, and Prevention." Heart Failure Clinics 13, no. 2 (April 2017): 337-345. (Review)  Full Text
    • Felker, GM, Mentz, RJ, Cole, RT, Adams, KF, Egnaczyk, GF, Fiuzat, M, Patel, CB, Echols, M, Khouri, MG, Tauras, JM, Gupta, D, Monds, P, Roberts, R, and O'Connor, CM. "Efficacy and Safety of Tolvaptan in Patients Hospitalized With Acute Heart Failure." Journal of the American College of Cardiology 69, no. 11 (March 2017): 1399-1406.  Full Text
    • Hunter, WG, Kelly, JP, McGarrah, RW, Khouri, MG, Craig, D, Haynes, C, Ilkayeva, O, Stevens, RD, Bain, JR, Muehlbauer, MJ, Newgard, CB, Felker, GM, Hernandez, AF, Velazquez, EJ, Kraus, WE, and Shah, SH. "Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure." Journal of the American Heart Association 5, no. 8 (July 29, 2016).  Full Text  Open Access Copy
    • Koelwyn, GJ, Lewis, NC, Ellard, SL, Jones, LW, Gelinas, JC, Rolf, JD, Melzer, B, Thomas, SM, Douglas, PS, Khouri, MG, and Eves, ND. "Ventricular-Arterial Coupling in Breast Cancer Patients After Treatment With Anthracycline-Containing Adjuvant Chemotherapy." ONCOLOGIST 21, no. 2 (February 2016): 141-149.  Full Text  Link to Item
    • Garg, S, de Lemos, JA, Ayers, C, Khouri, MG, Pandey, A, Berry, JD, Peshock, RM, and Drazner, MH. "Association of a 4-Tiered Classification of LV Hypertrophy With Adverse CV Outcomes in the General Population." JACC. Cardiovascular imaging 8, no. 9 (September 2015): 1034-1041.  Full Text
    • Mentz, RJ, and Khouri, MG. "Longitudinal Strain in Heart Failure With Preserved Ejection Fraction: Is There a Role for Prognostication?." Circulation 132, no. 5 (August 2015): 368-370.  Full Text
    • Hess, CN, Roe, MT, Clare, RM, Chiswell, K, Kelly, J, Tcheng, JE, Hagstrom, E, James, SK, Khouri, MG, Hirsch, BR, Kong, DF, Abernethy, AP, and Krucoff, MW. "Relationship Between Cancer and Cardiovascular Outcomes Following Percutaneous Coronary Intervention." Journal of the American Heart Association 4, no. 7 (July 6, 2015).  Full Text  Open Access Copy
    • Khouri, MG, Klein, MR, Velazquez, EJ, and Jones, LW. "Current and emerging modalities for detection of cardiotoxicity in cardio-oncology." Future cardiology 11, no. 4 (July 2015): 471-484. (Review)  Full Text
    • Kenjale, AA, Hornsby, WE, Crowgey, T, Thomas, S, Herndon, JE, Khouri, MG, Lane, AR, Bishop, CE, Eves, ND, Peppercorn, J, Douglas, PS, and Jones, LW. "Pre-exercise participation cardiovascular screening in a heterogeneous cohort of adult cancer patients." The Oncologist 19, no. 9 (September 2014): 999-1005.  Full Text
    • Jones, LW, Douglas, PS, Khouri, MG, Mackey, JR, Wojdyla, D, Kraus, WE, Whellan, DJ, and O'Connor, CM. "Safety and efficacy of aerobic training in patients with cancer who have heart failure: an analysis of the HF-ACTION randomized trial." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 32, no. 23 (August 2014): 2496-2502.  Full Text
    • Jones, LW, Hornsby, WE, Freedland, SJ, Lane, A, West, MJ, Moul, JW, Ferrandino, MN, Allen, JD, Kenjale, AA, Thomas, SM, Herndon, JE, Koontz, BF, Chan, JM, Khouri, MG, Douglas, PS, and Eves, ND. "Effects of nonlinear aerobic training on erectile dysfunction and cardiovascular function following radical prostatectomy for clinically localized prostate cancer." European Urology 65, no. 5 (May 2014): 852-855.  Full Text
    • Khouri, MG, Yoon, HJ, Schulte, P, and Velazquez, E. "GLOBAL LONGITUDINAL STRAIN BECOMES IMPAIRED IN CHEMOTHERAPY TREATED BREAST CANCER PATIENTS." Journal of the American College of Cardiology 63, no. 12 (April 2014): A1135-A1135.  Full Text
    • "Cancer therapy-induced autonomic dysfunction in early breast cancer: Implications for aerobic exercise training." International Journal of Cardiology 171, no. 2 (February 1, 2014).  Full Text
    • Khouri, MG, Hornsby, WE, Risum, N, Velazquez, EJ, Thomas, S, Lane, A, Scott, JM, Koelwyn, GJ, Herndon, JE, Mackey, JR, Douglas, PS, and Jones, LW. "Utility of 3-dimensional echocardiography, global longitudinal strain, and exercise stress echocardiography to detect cardiac dysfunction in breast cancer patients treated with doxorubicin-containing adjuvant therapy." Breast Cancer Res Treat 143, no. 3 (February 2014): 531-539.  Full Text  Link to Item
    • Mackey, JR, Douglas, PS, and Jones, LW. "Utility of 3-dimensional echocardiography, global longitudinal strain, and exercise stress echocardiography to detect cardiac dysfunction in breast cancer patients treated with doxorubicin-containing adjuvant therapy." Breast Cancer Research and Treatment 143, no. 3 (February 1, 2014): 531-539.  Full Text
    • Scott, JM, Jones, LW, Hornsby, WE, Koelwyn, GJ, Khouri, MG, Joy, AA, Douglas, PS, and Lakoski, SG. "Cancer therapy-induced autonomic dysfunction in early breast cancer: implications for aerobic exercise training." International Journal of Cardiology 171, no. 2 (February 2014): e50-e51. (Letter)  Full Text
    • Jones, LW, Hornsby, WE, Freedland, SJ, Lane, A, West, MJ, Moul, JW, Ferrandino, MN, Allen, JD, Kenjale, AA, Thomas, SM, Herndon, JE, Koontz, BF, Chan, JM, Khouri, MG, Douglas, PS, and Eves, ND. "Effects of nonlinear aerobic training on erectile dysfunction and cardiovascular function following radical prostatectomy for clinically localized prostate cancer." European Urology 65, no. 5 (January 1, 2014): 852-855.  Full Text
    • Scott, JM, Koelwyn, GJ, Khouri, MG, Douglas, PS, and Jones, LW. "Preventing Cardiovascular Complications of Breast Cancer Treatment: The Utility of Effective Exercise Prescription." Current Cardiovascular Risk Reports 7, no. 4 (August 2013): 275-282.  Full Text
    • Risum, N, Williams, ES, Khouri, MG, Jackson, KP, Olsen, NT, Jons, C, Storm, KS, Velazquez, EJ, Kisslo, J, Bruun, NE, and Sogaard, P. "Mechanical dyssynchrony evaluated by tissue Doppler cross-correlation analysis is associated with long-term survival in patients after cardiac resynchronization therapy." EUROPEAN HEART JOURNAL 34, no. 1 (January 2013): 48-56.  Full Text  Link to Item
    • Scott, JM, Koelwyn, GJ, Hornsby, WE, Khouri, M, Peppercorn, J, Douglas, PS, and Jones, LW. "Exercise therapy as treatment for cardiovascular and oncologic disease after a diagnosis of early-stage cancer." Seminars in Oncology 40, no. 2 (2013): 218-228.  Full Text
    • Khouri, MG, Douglas, PS, Mackey, JR, Martin, M, Scott, JM, Scherrer-Crosbie, M, and Jones, LW. "Cancer therapy-induced cardiac toxicity in early breast cancer: addressing the unresolved issues." Circulation 126, no. 23 (December 2012): 2749-2763. (Review)  Full Text
    • Koelwyn, GJ, Khouri, M, Mackey, JR, Douglas, PS, and Jones, LW. "Running on empty: cardiovascular reserve capacity and late effects of therapy in cancer survivorship." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 30, no. 36 (December 2012): 4458-4461. (Review)  Full Text
    • Khouri, MG, Jones, LW, Shaw, LK, Douglas, PS, Borges-Neto, S, and Velazquez, EJ. "Left Ventricular Systolic Dysfunction at Baseline and Follow-up is Associated with Long-term Survival in Chemotherapy Treated Breast Cancer Patients." CIRCULATION 126, no. 21 (November 20, 2012).  Link to Item
    • Risum, N, Ali, S, Olsen, NT, Jons, C, Khouri, MG, Lauridsen, TK, Samad, Z, Velazquez, EJ, Sogaard, P, and Kisslo, J. "Variability of global left ventricular deformation analysis using vendor dependent and independent two-dimensional speckle-tracking software in adults." Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography 25, no. 11 (November 2012): 1195-1203.  Full Text
    • Hornsby, WE, Khouri, MG, Lakoski, SG, Ainslie, P, Smirl, J, West, M, Lane, A, Coan, A, Ona, F, Klaunig, JE, Koceja, DM, Chapman, RF, and Jones, LW. "Autonomic and Cardiovascular Function of Hormone-Receptor Positive Breast Cancer Patients Following Treatment with Anthracycline-Containing Chemotherapy." MEDICINE AND SCIENCE IN SPORTS AND EXERCISE 44 (May 2012): 735-735.  Link to Item
    • Khouri, MG, Hornsby, W, Velazquez, EJ, Jones, LW, and Douglas, PS. "Exercise Stress Testing With Strain Echocardiography is Superior to Resting Echocardiography in Identifying Doxorubicin-Induced Preclinical LV Dysfunction in Breast Cancer Patients." CIRCULATION 124, no. 21 (November 22, 2011).  Link to Item
    • Khouri, MG, Peshock, RM, Ayers, CR, de Lemos, JA, and Drazner, MH. "A 4-tiered classification of left ventricular hypertrophy based on left ventricular geometry: the Dallas heart study." Circulation. Cardiovascular Imaging 3, no. 2 (March 2010): 164-171.  Full Text
    • Khouri, MG, Maurer, MS, and Rumbarger, LE-K. "Assessment of age-related changes in left ventricular structure and function by freehand three-dimensional echocardiography." The American journal of geriatric cardiology 14, no. 3 (2005): 118-125.

  • Book Sections

    • Khouri, MG, Klem, I, Shenoy, C, Sulpher, J, and Dent, SF. "Screening and Monitoring for Cardiotoxicity During Cancer Treatment." In Cardio-Oncology, 43-80.: Springer International Publishing, 2017.  Full Text

  • Conference Papers

    • Melloni, C, Dunning, A, Granger, CB, Thomas, L, Khouri, MG, Garcia, DA, Hylek, EM, Hanna, M, Wallentin, L, Gersh, BJ, Douglas, PS, Alexander, JH, and Lopes, RD. "Efficacy and Safety of Apixaban Versus Warfarin in Patients with Atrial Fibrillation and a History of Cancer: Insights from the ARISTOTLE Trial." December 2017.  Full Text
    • Buggey, J, Alenezi, F, Yoon, HJ, Phelan, M, DeVore, AD, Khouri, MG, Schulte, PJ, and Velazquez, EJ. "Left ventricular global longitudinal strain in patients with heart failure with preserved ejection fraction: outcomes following an acute heart failure hospitalization." November 2017.  Full Text
    • DeVore, AD, Alenezi, F, Krishnamoorthy, A, Ersboll, M, Samsky, MD, Schulte, PJ, Patel, CB, Rogers, JG, Milano, CA, Velazquez, EJ, and Khouri, MG. "Assessment of cardiac allograft systolic function by global longitudinal strain: From donor to recipient." May 2017.  Full Text
    • Hunter, WG, Kelly, JP, McGarrah, RW, Khouri, MG, Craig, DM, Haynes, C, Ilkayeva, O, Stevens, RD, Muehlbauer, MJ, Newgard, CB, Felker, GM, Hernandez, AF, Velazquez, EJ, Kraus, WE, and Shah, SH. "Plasma amino acid concentrations are independently associated with adverse outcomes in heart failure and preserved ejection fraction: prognostic utility of amino acid profiles in HFpEF." August 1, 2016.  Link to Item
    • Koelwyn, GJ, Lewis, NC, Ellard, SL, Jones, LW, Gelinas, JC, Rolf, JD, Melzer, B, Thomas, SM, Douglas, PS, Khouri, MG, and Eves, ND. "Ventricular-Arterial Coupling in Breast Cancer Patients After Treatment With Anthracycline-Containing Adjuvant Chemotherapy." February 2016.  Full Text
    • Khouri, MG, Ky, B, Dunn, G, Plappert, T, Englefield, V, Yow, E, Barnhart, HX, Sutton, MSJ, and Douglas, P. "ECHOCARDIOGRAPHY CORE LAB REPRODUCIBILITY OF CARDIAC SAFETY ASSESSMENTS IN CARDIO-ONCOLOGY." March 2015.  Full Text

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