Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Resident, Internal Medicine, University of Texas Southwestern Medical Center, Medical School 2004 - 2007
  • M.D., Columbia University 2004
• 

  Duke Appointment History

  • Medical Instructor in the Department of Medicine, Medicine, Cardiology, Medicine 2012 - 2013
• Research
• 

  Selected Grants

  • A Phase III, Open-Label, Multicenter Trial to Evaluate Ejection Fraction, End-Diastolic and End-Systolic Volumes, by Unenhanced and DEFINITY®-enhanced 2D-Echo and Magnetic Resonance Imaging awarded by Lantheus Medical Imaging 2019 - 2024
  • Strategy to Improve Patient Outcomes by Silencing TTR Formation in ATTR-CM awarded by Ionis Pharmaceuticals Inc 2020 - 2023
  • Helios-B: A Phase 3 Global, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Clinical Outcomes, Efficacy and Safety of Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy (ATTR amyloidosis with cardiomyopathy) awarded by Alnylam Pharmaceuticals 2020 - 2023
  • AG10-301 ATTRIBUTE awarded by Eidos Therapeutics 2019 - 2022
  • Attract Extension-- Endeavor Extension Study awarded by Pfizer, Inc. 2016 - 2021
  • A Phase III, Open Label, Multicenter Trial to Evaluate Ejection Fraction, End Diastolic and End Systolic Volumes, by Unenhanced and DEFINITY enhanced 2D-Echo and Magnetic Resonance Imaging awarded by Lantheus Medical Imaging 2018 - 2020
  • ISCHEMIA: International Study of Comparative Health Effectiveness with Medical and Invasive Approaches awarded by New York University School of Medicine 2014 - 2020
  • EXCITE awarded by Sloan Kettering Institute 2018 - 2019
  • Educational Preceptorship Program awarded by Pfizer, Inc. 2019
  • International Study of Comparative Health Effectiveness with Medical and Invasive Approaches awarded by New York University School of Medicine 2014 - 2018
  • SCUSF 0806 Phase II placebo--controlled trial of lisinopril and Coreg awarded by University of South Florida 2013 - 2014
• 

  External Relationships

  • Alnylam Pharmaceutical, Inc.
  • Chimerix Inc
  • Eidos Therapeutics
  • Pfizer Inc.
  • SpringWorks Therapeutics
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Lopes, Renato D., Karen P. Alexander, Susanna R. Stevens, Harmony R. Reynolds, Gregg W. Stone, Ileana L. Piña, Frank W. Rockhold, et al. “Initial Invasive Versus Conservative Management of Stable Ischemic Heart Disease in Patients With a History of Heart Failure or Left Ventricular Dysfunction: Insights From the ISCHEMIA Trial.” Circulation 142, no. 18 (November 3, 2020): 1725–35. https://doi.org/10.1161/CIRCULATIONAHA.120.050304.
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    • Rehorn, Michael R., Rahul S. Loungani, Eric Black-Maier, Amanda C. Coniglio, Ravi Karra, Sean D. Pokorney, and Michel G. Khouri. “Cardiac Implantable Electronic Devices: A Window Into the Evolution of Conduction Disease in Cardiac Amyloidosis.” Jacc Clin Electrophysiol 6, no. 9 (September 2020): 1144–54. https://doi.org/10.1016/j.jacep.2020.04.020.
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    • Abdulrahim, Jawan W., Lydia Coulter Kwee, Fawaz Alenezi, Albert Y. Sun, Aris Baras, Teminioluwa A. Ajayi, Ricardo Henao, et al. “Identification of Undetected Monogenic Cardiovascular Disorders.” J Am Coll Cardiol 76, no. 7 (August 18, 2020): 797–808. https://doi.org/10.1016/j.jacc.2020.06.037.
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    • Black-Maier, Eric, Michael Rehorn, Rahul Loungani, Daniel J. Friedman, Fawaz Alenezi, Kyle Geurink, Sean D. Pokorney, et al. “Catheter ablation of atrial fibrillation in cardiac amyloidosis.” Pacing Clin Electrophysiol, June 23, 2020. https://doi.org/10.1111/pace.13992.
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    • Melloni, Chiara, and Michel G. Khouri. “Considerations for Long-Term Anticoagulation for Stroke Prevention in Patients With Atrial Fibrillation and Cancer.” J Oncol Pract 15, no. 12 (December 2019): 651–52. https://doi.org/10.1200/JOP.19.00597.
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    • Hunter, Wynn G., Robert W. McGarrah, Jacob P. Kelly, Michel G. Khouri, Damian M. Craig, Carol Haynes, G Michael Felker, et al. “High-Density Lipoprotein Particle Subfractions in Heart Failure With Preserved or Reduced Ejection Fraction.” J Am Coll Cardiol 73, no. 2 (January 22, 2019): 177–86. https://doi.org/10.1016/j.jacc.2018.10.059.
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    • Kochar, Ajar, Jennifer Rymer, Zainab Samad, and Zainab Duke Cardiovascular Education Group. “Disrupting Fellow Education Through Group Texting: WhatsApp in Fellow Education?” J Am Coll Cardiol 72, no. 25 (December 25, 2018): 3366–69. https://doi.org/10.1016/j.jacc.2018.11.007.
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    • Khouri, Michel G., and Michael R. Harrison. “Look and You Will Find It: Practical Considerations for Improving Multidisciplinary Management of Androgen-Deprivation Therapy-Induced Cardiometabolic Toxicity.” J Oncol Pract 14, no. 10 (October 2018): 591–93. https://doi.org/10.1200/JOP.18.00543.
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    • Khouri, Michel G., Bonnie Ky, Gary Dunn, Ted Plappert, Virginia Englefield, Dawn Rabineau, Eric Yow, Huiman X. Barnhart, Martin St John Sutton, and Pamela S. Douglas. “Echocardiography Core Laboratory Reproducibility of Cardiac Safety Assessments in Cardio-Oncology.” J Am Soc Echocardiogr 31, no. 3 (March 2018): 361-371.e3. https://doi.org/10.1016/j.echo.2017.11.018.
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    • Armenian, Saro H., Thomas D. Ryan, and Michel G. Khouri. “Cardiac Dysfunction and Heart Failure in Hematopoietic Cell Transplantation Survivors: Emerging Paradigms in Pathophysiology, Screening, and Prevention.” Heart Fail Clin 13, no. 2 (April 2017): 337–45. https://doi.org/10.1016/j.hfc.2016.12.008.
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    • Felker, G Michael, Robert J. Mentz, Robert T. Cole, Kirkwood F. Adams, Gregory F. Egnaczyk, Mona Fiuzat, Chetan B. Patel, et al. “Efficacy and Safety of Tolvaptan in Patients Hospitalized With Acute Heart Failure.” Journal of the American College of Cardiology 69, no. 11 (March 2017): 1399–1406. https://doi.org/10.1016/j.jacc.2016.09.004.
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    • Hunter, Wynn G., Jacob P. Kelly, Robert W. McGarrah, Michel G. Khouri, Damian Craig, Carol Haynes, Olga Ilkayeva, et al. “Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure.” J Am Heart Assoc 5, no. 8 (July 29, 2016). https://doi.org/10.1161/JAHA.115.003190.
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    • Garg, Sonia, James A. de Lemos, Colby Ayers, Michel G. Khouri, Ambarish Pandey, Jarett D. Berry, Ronald M. Peshock, and Mark H. Drazner. “Association of a 4-Tiered Classification of LV Hypertrophy With Adverse CV Outcomes in the General Population.” Jacc Cardiovasc Imaging 8, no. 9 (September 2015): 1034–41. https://doi.org/10.1016/j.jcmg.2015.06.007.
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    • Mentz, Robert J., and Michel G. Khouri. “Longitudinal Strain in Heart Failure With Preserved Ejection Fraction: Is There a Role for Prognostication?” Circulation 132, no. 5 (August 4, 2015): 368–70. https://doi.org/10.1161/CIRCULATIONAHA.115.017683.
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    • Hess, Connie N., Matthew T. Roe, Robert M. Clare, Karen Chiswell, Joseph Kelly, James E. Tcheng, Emil Hagstrom, et al. “Relationship Between Cancer and Cardiovascular Outcomes Following Percutaneous Coronary Intervention.” J Am Heart Assoc 4, no. 7 (July 6, 2015). https://doi.org/10.1161/JAHA.115.001779.
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    • Khouri, Michel G., Michael R. Klein, Eric J. Velazquez, and Lee W. Jones. “Current and emerging modalities for detection of cardiotoxicity in cardio-oncology.” Future Cardiol 11, no. 4 (July 2015): 471–84. https://doi.org/10.2217/fca.15.16.
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    • Kenjale, Aarti A., Whitney E. Hornsby, Theresa Crowgey, Samantha Thomas, James E. Herndon, Michel G. Khouri, Amy R. Lane, et al. “Pre-exercise participation cardiovascular screening in a heterogeneous cohort of adult cancer patients.” Oncologist 19, no. 9 (September 2014): 999–1005. https://doi.org/10.1634/theoncologist.2014-0078.
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    • Jones, Lee W., Pamela S. Douglas, Michel G. Khouri, John R. Mackey, Daniel Wojdyla, William E. Kraus, David J. Whellan, and Christopher M. O’Connor. “Safety and efficacy of aerobic training in patients with cancer who have heart failure: an analysis of the HF-ACTION randomized trial.” J Clin Oncol 32, no. 23 (August 10, 2014): 2496–2502. https://doi.org/10.1200/JCO.2013.53.5724.
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    • Jones, Lee W., Whitney E. Hornsby, Stephen J. Freedland, Amy Lane, Miranda J. West, Judd W. Moul, Michael N. Ferrandino, et al. “Effects of nonlinear aerobic training on erectile dysfunction and cardiovascular function following radical prostatectomy for clinically localized prostate cancer.” Eur Urol 65, no. 5 (May 2014): 852–55. https://doi.org/10.1016/j.eururo.2013.11.009.
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    • Khouri, Michel Georges, Hyun Ju Yoon, Phillip Schulte, and Eric Velazquez. “GLOBAL LONGITUDINAL STRAIN BECOMES IMPAIRED IN CHEMOTHERAPY TREATED BREAST CANCER PATIENTS.” Journal of the American College of Cardiology 63, no. 12 (April 2014): A1135–A1135. https://doi.org/10.1016/s0735-1097(14)61135-9.
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    • Khouri, Michel G., Whitney E. Hornsby, Niels Risum, Eric J. Velazquez, Samantha Thomas, Amy Lane, Jessica M. Scott, et al. “Utility of 3-dimensional echocardiography, global longitudinal strain, and exercise stress echocardiography to detect cardiac dysfunction in breast cancer patients treated with doxorubicin-containing adjuvant therapy.” Breast Cancer Res Treat 143, no. 3 (February 2014): 531–39. https://doi.org/10.1007/s10549-013-2818-1.
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    • Scott, Jessica M., Lee W. Jones, Whitney E. Hornsby, Graeme J. Koelwyn, Michel G. Khouri, Anil A. Joy, Pamela S. Douglas, and Susan G. Lakoski. “Cancer therapy-induced autonomic dysfunction in early breast cancer: implications for aerobic exercise training.” Int J Cardiol 171, no. 2 (February 1, 2014): e50–51. https://doi.org/10.1016/j.ijcard.2013.11.113.
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    • Scott, J. M., G. J. Koelwyn, M. G. Khouri, P. S. Douglas, and L. W. Jones. “Preventing Cardiovascular Complications of Breast Cancer Treatment: The Utility of Effective Exercise Prescription.” Current Cardiovascular Risk Reports 7, no. 4 (August 1, 2013): 275–82. https://doi.org/10.1007/s12170-013-0319-8.
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    • Scott, Jessica M., Graeme J. Koelwyn, Whitney E. Hornsby, Michel Khouri, Jeffrey Peppercorn, Pamela S. Douglas, and Lee W. Jones. “Exercise therapy as treatment for cardiovascular and oncologic disease after a diagnosis of early-stage cancer.” Semin Oncol 40, no. 2 (April 2013): 218–28. https://doi.org/10.1053/j.seminoncol.2013.01.001.
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    • Risum, Niels, Eric S. Williams, Michel G. Khouri, Kevin P. Jackson, Niels Thue Olsen, Christian Jons, Katrine S. Storm, et al. “Mechanical dyssynchrony evaluated by tissue Doppler cross-correlation analysis is associated with long-term survival in patients after cardiac resynchronization therapy.” Eur Heart J 34, no. 1 (January 2013): 48–56. https://doi.org/10.1093/eurheartj/ehs035.
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    • Koelwyn, Graeme J., Michel Khouri, John R. Mackey, Pamela S. Douglas, and Lee W. Jones. “Running on empty: cardiovascular reserve capacity and late effects of therapy in cancer survivorship.” J Clin Oncol 30, no. 36 (December 20, 2012): 4458–61. https://doi.org/10.1200/JCO.2012.44.0891.
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    • Khouri, Michel G., Pamela S. Douglas, John R. Mackey, Miguel Martin, Jessica M. Scott, Marielle Scherrer-Crosbie, and Lee W. Jones. “Cancer therapy-induced cardiac toxicity in early breast cancer: addressing the unresolved issues.” Circulation 126, no. 23 (December 4, 2012): 2749–63. https://doi.org/10.1161/CIRCULATIONAHA.112.100560.
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    • Khouri, Michel G., Lee W. Jones, Linda K. Shaw, Pamela S. Douglas, Salvador Borges-Neto, and Eric J. Velazquez. “Left Ventricular Systolic Dysfunction at Baseline and Follow-up is Associated with Long-term Survival in Chemotherapy Treated Breast Cancer Patients.” Circulation 126, no. 21 (November 20, 2012).
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    • Risum, Niels, Sophia Ali, Niels T. Olsen, Christian Jons, Michel G. Khouri, Trine K. Lauridsen, Zainab Samad, Eric J. Velazquez, Peter Sogaard, and Joseph Kisslo. “Variability of global left ventricular deformation analysis using vendor dependent and independent two-dimensional speckle-tracking software in adults.” J Am Soc Echocardiogr 25, no. 11 (November 2012): 1195–1203. https://doi.org/10.1016/j.echo.2012.08.007.
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    • Hornsby, Whitney E., Michel G. Khouri, Susan G. Lakoski, Phil Ainslie, Jonathon Smirl, Miranda West, Amy Lane, et al. “Autonomic and Cardiovascular Function of Hormone-Receptor Positive Breast Cancer Patients Following Treatment with Anthracycline-Containing Chemotherapy.” Medicine and Science in Sports and Exercise 44 (May 1, 2012): 735–735.
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    • Khouri, Michel G., Whitney Hornsby, Eric J. Velazquez, Lee W. Jones, and Pamela S. Douglas. “Exercise Stress Testing With Strain Echocardiography is Superior to Resting Echocardiography in Identifying Doxorubicin-Induced Preclinical LV Dysfunction in Breast Cancer Patients.” Circulation 124, no. 21 (November 22, 2011).
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    • Khouri, Michel G., Ronald M. Peshock, Colby R. Ayers, James A. de Lemos, and Mark H. Drazner. “A 4-tiered classification of left ventricular hypertrophy based on left ventricular geometry: the Dallas heart study.” Circ Cardiovasc Imaging 3, no. 2 (March 2010): 164–71. https://doi.org/10.1161/CIRCIMAGING.109.883652.
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    • Khouri, Michel G., Mathew S. Maurer, and Lyna El-Khoury Rumbarger. “Assessment of age-related changes in left ventricular structure and function by freehand three-dimensional echocardiography.” Am J Geriatr Cardiol 14, no. 3 (May 2005): 118–25. https://doi.org/10.1111/j.1076-7460.2005.03845.x.
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  • Book Sections

    • Khouri, M. G., I. Klem, C. Shenoy, J. Sulpher, and S. F. Dent. “Screening and monitoring for cardiotoxicity during cancer treatment.” In Cardio-Oncology: The Clinical Overlap of Cancer and Heart Disease, 43–80, 2017. https://doi.org/10.1007/978-3-319-43096-6_3.
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  • Conference Papers

    • Harrison, M. R., P. G. Davis, M. G. Khouri, R. T. Gupta, A. J. Armstrong, M. A. McNamara, T. Zhang, et al. “EXTEND: Safety and efficacy of exercise training in men receiving enzalutamide (ENZ) in combination with conventional androgen deprivation therapy (ADT) for hormone naïve prostate cancer (HSPC).” In Ann Oncol, 29 Suppl 8:viii623–24, 2018. https://doi.org/10.1093/annonc/mdy300.064.
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    • Melloni, Chiara, Allison Dunning, Christopher B. Granger, Laine Thomas, Michel G. Khouri, David A. Garcia, Elaine M. Hylek, et al. “Efficacy and Safety of Apixaban Versus Warfarin in Patients with Atrial Fibrillation and a History of Cancer: Insights from the ARISTOTLE Trial.” In Am J Med, 130:1440-1448.e1, 2017. https://doi.org/10.1016/j.amjmed.2017.06.026.
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    • Buggey, Jonathan, Fawaz Alenezi, Hyun Ju Yoon, Matthew Phelan, Adam D. DeVore, Michel G. Khouri, Phillip J. Schulte, and Eric J. Velazquez. “Left ventricular global longitudinal strain in patients with heart failure with preserved ejection fraction: outcomes following an acute heart failure hospitalization.” In Esc Heart Failure, 4:432–39, 2017. https://doi.org/10.1002/ehf2.12159.
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    • DeVore, Adam D., Fawaz Alenezi, Arun Krishnamoorthy, Mads Ersboll, Marc D. Samsky, Phillip J. Schulte, Chetan B. Patel, et al. “Assessment of cardiac allograft systolic function by global longitudinal strain: From donor to recipient.” In Clin Transplant, Vol. 31, 2017. https://doi.org/10.1111/ctr.12961.
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    • Hunter, W. G., J. P. Kelly, R. W. McGarrah, M. G. Khouri, D. M. Craig, C. Haynes, O. Ilkayeva, et al. “Plasma amino acid concentrations are independently associated with adverse outcomes in heart failure and preserved ejection fraction: prognostic utility of amino acid profiles in HFpEF.” In European Heart Journal, 37:330–330. OXFORD UNIV PRESS, 2016.
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    • Koelwyn, Graeme J., Nia C. Lewis, Susan L. Ellard, Lee W. Jones, Jinelle C. Gelinas, J Douglass Rolf, Bernie Melzer, et al. “Ventricular-Arterial Coupling in Breast Cancer Patients After Treatment With Anthracycline-Containing Adjuvant Chemotherapy.” In The Oncologist, 21:141–49, 2016. https://doi.org/10.1634/theoncologist.2015-0352.
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    • Khouri, Michel Georges, Bonnie Ky, Gary Dunn, Theodore Plappert, Virginia Englefield, Eric Yow, Huiman X. Barnhart, Martin St John Sutton, and Pamela Douglas. “ECHOCARDIOGRAPHY CORE LAB REPRODUCIBILITY OF CARDIAC SAFETY ASSESSMENTS IN CARDIO-ONCOLOGY.” In Journal of the American College of Cardiology, 65:A1323–A1323. Elsevier BV, 2015. https://doi.org/10.1016/s0735-1097(15)61323-7.
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