Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., Columbia University 2004
• 

  Duke Appointment History

  • Medical Instructor in the Department of Medicine, Medicine, Cardiology, Medicine 2012 - 2013
• Research
• 

  Selected Grants

  • ISCHEMIA-CKD awarded by New York University School of Medicine 2014 - 2019
  • CIAO ISCHEMIA awarded by New York University School of Medicine 2014 - 2018
  • SCUSF 0806 Phase II placebo--controlled trial of lisinopril and Coreg awarded by University of South Florida 2013 - 2014
• Publications & Artistic Works
• 

  Selected Publications

  • Book Sections

    • Khouri, MG, Klem, I, Shenoy, C, Sulpher, J, and Dent, SF. "Screening and monitoring for cardiotoxicity during cancer treatment." In Cardio-Oncology: The Clinical Overlap of Cancer and Heart Disease, 43-80. April 11, 2017.  Full Text

  • Conference Papers

    • Melloni, C, Dunning, A, Granger, CB, Thomas, L, Khouri, MG, Garcia, DA, Hylek, EM, Hanna, M, Wallentin, L, Gersh, BJ, Douglas, PS, Alexander, JH, and Lopes, RD. "Efficacy and Safety of Apixaban Versus Warfarin in Patients with Atrial Fibrillation and a History of Cancer: Insights from the ARISTOTLE Trial." December 2017.  Full Text
    • Buggey, J, Alenezi, F, Yoon, HJ, Phelan, M, DeVore, AD, Khouri, MG, Schulte, PJ, and Velazquez, EJ. "Left ventricular global longitudinal strain in patients with heart failure with preserved ejection fraction: outcomes following an acute heart failure hospitalization." November 2017.  Full Text
    • DeVore, AD, Alenezi, F, Krishnamoorthy, A, Ersboll, M, Samsky, MD, Schulte, PJ, Patel, CB, Rogers, JG, Milano, CA, Velazquez, EJ, and Khouri, MG. "Assessment of cardiac allograft systolic function by global longitudinal strain: From donor to recipient." May 2017.  Full Text
    • Hunter, WG, Kelly, JP, McGarrah, RW, Khouri, MG, Craig, DM, Haynes, C, Ilkayeva, O, Stevens, RD, Muehlbauer, MJ, Newgard, CB, Felker, GM, Hernandez, AF, Velazquez, EJ, Kraus, WE, and Shah, SH. "Plasma amino acid concentrations are independently associated with adverse outcomes in heart failure and preserved ejection fraction: prognostic utility of amino acid profiles in HFpEF." August 1, 2016.  Link to Item
    • Koelwyn, GJ, Lewis, NC, Ellard, SL, Jones, LW, Gelinas, JC, Rolf, JD, Melzer, B, Thomas, SM, Douglas, PS, Khouri, MG, and Eves, ND. "Ventricular-Arterial Coupling in Breast Cancer Patients After Treatment With Anthracycline-Containing Adjuvant Chemotherapy." February 2016.  Full Text
    • Khouri, MG, Ky, B, Dunn, G, Plappert, T, Englefield, V, Yow, E, Barnhart, HX, Sutton, MSJ, and Douglas, P. "ECHOCARDIOGRAPHY CORE LAB REPRODUCIBILITY OF CARDIAC SAFETY ASSESSMENTS IN CARDIO-ONCOLOGY." March 2015.  Full Text

  • Journal Articles

    • Khouri, MG, Ky, B, Dunn, G, Plappert, T, Englefield, V, Rabineau, D, Yow, E, Barnhart, HX, St John Sutton, M, and Douglas, PS. "Echocardiography Core Laboratory Reproducibility of Cardiac Safety Assessments in Cardio-Oncology." Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 31, no. 3 (March 2018): 361-371.e3.  Full Text
    • Armenian, SH, Ryan, TD, and Khouri, MG. "Cardiac Dysfunction and Heart Failure in Hematopoietic Cell Transplantation Survivors: Emerging Paradigms in Pathophysiology, Screening, and Prevention." Heart failure clinics 13, no. 2 (April 2017): 337-345. (Review)  Full Text
    • Felker, GM, Mentz, RJ, Cole, RT, Adams, KF, Egnaczyk, GF, Fiuzat, M, Patel, CB, Echols, M, Khouri, MG, Tauras, JM, Gupta, D, Monds, P, Roberts, R, and O'Connor, CM. "Efficacy and Safety of Tolvaptan in Patients Hospitalized With Acute Heart Failure." Journal of the American College of Cardiology 69, no. 11 (March 2017): 1399-1406.  Full Text
    • Hunter, WG, Kelly, JP, McGarrah, RW, Khouri, MG, Craig, D, Haynes, C, Ilkayeva, O, Stevens, RD, Bain, JR, Muehlbauer, MJ, Newgard, CB, Felker, GM, Hernandez, AF, Velazquez, EJ, Kraus, WE, and Shah, SH. "Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure." Journal of the American Heart Association 5, no. 8 (July 29, 2016).  Full Text  Open Access Copy
    • Koelwyn, GJ, Lewis, NC, Ellard, SL, Jones, LW, Gelinas, JC, Rolf, JD, Melzer, B, Thomas, SM, Douglas, PS, Khouri, MG, and Eves, ND. "Ventricular-Arterial Coupling in Breast Cancer Patients After Treatment With Anthracycline-Containing Adjuvant Chemotherapy." ONCOLOGIST 21, no. 2 (February 2016): 141-149.  Full Text  Link to Item
    • Garg, S, de Lemos, JA, Ayers, C, Khouri, MG, Pandey, A, Berry, JD, Peshock, RM, and Drazner, MH. "Association of a 4-Tiered Classification of LV Hypertrophy With Adverse CV Outcomes in the General Population." JACC. Cardiovascular imaging 8, no. 9 (September 2015): 1034-1041.  Full Text
    • Mentz, RJ, and Khouri, MG. "Longitudinal Strain in Heart Failure With Preserved Ejection Fraction: Is There a Role for Prognostication?." Circulation 132, no. 5 (August 2015): 368-370.  Full Text
    • Hess, CN, Roe, MT, Clare, RM, Chiswell, K, Kelly, J, Tcheng, JE, Hagstrom, E, James, SK, Khouri, MG, Hirsch, BR, Kong, DF, Abernethy, AP, and Krucoff, MW. "Relationship Between Cancer and Cardiovascular Outcomes Following Percutaneous Coronary Intervention." Journal of the American Heart Association 4, no. 7 (July 6, 2015).  Full Text  Open Access Copy
    • Khouri, MG, Klein, MR, Velazquez, EJ, and Jones, LW. "Current and emerging modalities for detection of cardiotoxicity in cardio-oncology." Future cardiology 11, no. 4 (July 2015): 471-484. (Review)  Full Text
    • Kenjale, AA, Hornsby, WE, Crowgey, T, Thomas, S, Herndon, JE, Khouri, MG, Lane, AR, Bishop, CE, Eves, ND, Peppercorn, J, Douglas, PS, and Jones, LW. "Pre-exercise participation cardiovascular screening in a heterogeneous cohort of adult cancer patients." The oncologist 19, no. 9 (September 2014): 999-1005.  Full Text
    • Jones, LW, Douglas, PS, Khouri, MG, Mackey, JR, Wojdyla, D, Kraus, WE, Whellan, DJ, and O'Connor, CM. "Safety and efficacy of aerobic training in patients with cancer who have heart failure: an analysis of the HF-ACTION randomized trial." Journal of clinical oncology : official journal of the American Society of Clinical Oncology 32, no. 23 (August 2014): 2496-2502.  Full Text
    • Khouri, MG, Yoon, HJ, Schulte, P, and Velazquez, E. "GLOBAL LONGITUDINAL STRAIN BECOMES IMPAIRED IN CHEMOTHERAPY TREATED BREAST CANCER PATIENTS." Journal of the American College of Cardiology 63, no. 12 (April 2014): A1135-A1135.  Full Text
    • Khouri, MG, Hornsby, WE, Risum, N, Velazquez, EJ, Thomas, S, Lane, A, Scott, JM, Koelwyn, GJ, Herndon, JE, Mackey, JR, Douglas, PS, and Jones, LW. "Utility of 3-dimensional echocardiography, global longitudinal strain, and exercise stress echocardiography to detect cardiac dysfunction in breast cancer patients treated with doxorubicin-containing adjuvant therapy." Breast Cancer Res Treat 143, no. 3 (February 2014): 531-539.  Full Text  Link to Item
    • Khouri, MG, Hornsby, WE, Risum, N, Velazquez, EJ, Thomas, S, Lane, A, Scott, JM, Koelwyn, GJ, Herndon, JE, Mackey, JR, Douglas, PS, and Jones, LW. "Utility of 3-dimensional echocardiography, global longitudinal strain, and exercise stress echocardiography to detect cardiac dysfunction in breast cancer patients treated with doxorubicin-containing adjuvant therapy." Breast Cancer Research and Treatment 143, no. 3 (February 1, 2014): 531-539.  Full Text
    • Scott, JM, Jones, LW, Hornsby, WE, Koelwyn, GJ, Khouri, MG, Joy, AA, Douglas, PS, and Lakoski, SG. "Cancer therapy-induced autonomic dysfunction in early breast cancer: implications for aerobic exercise training." Int J Cardiol 171, no. 2 (February 1, 2014): e50-e51. (Letter)  Full Text  Link to Item
    • Scott, JM, Jones, LW, Hornsby, WE, Koelwyn, GJ, Khouri, MG, Joy, AA, Douglas, PS, and Lakoski, SG. "Cancer therapy-induced autonomic dysfunction in early breast cancer: Implications for aerobic exercise training." International Journal of Cardiology 171, no. 2 (February 1, 2014). (Letter)  Full Text
    • Jones, LW, Hornsby, WE, Freedland, SJ, Lane, A, West, MJ, Moul, JW, Ferrandino, MN, Allen, JD, Kenjale, AA, Thomas, SM, Herndon, JE, Koontz, BF, Chan, JM, Khouri, MG, Douglas, PS, and Eves, ND. "Effects of nonlinear aerobic training on erectile dysfunction and cardiovascular function following radical prostatectomy for clinically localized prostate cancer." European Urology 65, no. 5 (January 1, 2014): 852-855.  Full Text
    • Jones, LW, Hornsby, WE, Freedland, SJ, Lane, A, West, MJ, Moul, JW, Ferrandino, MN, Allen, JD, Kenjale, AA, Thomas, SM, Herndon II, JE, Koontz, BF, Chan, JM, Khouri, MG, Douglas, PS, and Eves, ND. "Effects of Nonlinear Aerobic Training on Erectile Dysfunction and Cardiovascular Function Following Radical Prostatectomy for Clinically Localized Prostate Cancer." European Urology (2013).
    • Risum, N, Williams, ES, Khouri, MG, Jackson, KP, Olsen, NT, Jons, C, Storm, KS, Velazquez, EJ, Kisslo, J, Bruun, NE, and Sogaard, P. "Mechanical dyssynchrony evaluated by tissue Doppler cross-correlation analysis is associated with long-term survival in patients after cardiac resynchronization therapy." European Heart Journal 34, no. 1 (2013): 48-56.  Full Text
    • Scott, JM, Koelwyn, GJ, Hornsby, WE, Khouri, M, Peppercorn, J, Douglas, PS, and Jones, LW. "Exercise therapy as treatment for cardiovascular and oncologic disease after a diagnosis of early-stage cancer." Seminars in Oncology 40, no. 2 (2013): 218-228.  Full Text
    • Scott, JM, Koelwyn, GJ, Khouri, MG, Douglas, PS, and Jones, LW. "Preventing Cardiovascular Complications of Breast Cancer Treatment: The Utility of Effective Exercise Prescription." Current Cardiovascular Risk Reports 7, no. 4 (2013): 275-282.  Full Text
    • Koelwyn, GJ, Khouri, M, Mackey, JR, Douglas, PS, and Jones, LW. "Running on empty: cardiovascular reserve capacity and late effects of therapy in cancer survivorship." J Clin Oncol 30, no. 36 (December 20, 2012): 4458-4461. (Review)  Full Text  Link to Item
    • Khouri, MG, Douglas, PS, Mackey, JR, Martin, M, Scott, JM, Scherrer-Crosbie, M, and Jones, LW. "Cancer therapy-induced cardiac toxicity in early breast cancer: addressing the unresolved issues." Circulation 126, no. 23 (December 4, 2012): 2749-2763. (Review)  Full Text  Link to Item
    • Khouri, MG, Jones, LW, Shaw, LK, Douglas, PS, Borges-Neto, S, and Velazquez, EJ. "Left Ventricular Systolic Dysfunction at Baseline and Follow-up is Associated with Long-term Survival in Chemotherapy Treated Breast Cancer Patients." CIRCULATION 126, no. 21 (November 20, 2012).  Link to Item
    • Risum, N, Ali, S, Olsen, NT, Jons, C, Khouri, MG, Lauridsen, TK, Samad, Z, Velazquez, EJ, Sogaard, P, and Kisslo, J. "Variability of global left ventricular deformation analysis using vendor dependent and independent two-dimensional speckle-tracking software in adults." J Am Soc Echocardiogr 25, no. 11 (November 2012): 1195-1203.  Full Text  Link to Item
    • Hornsby, WE, Khouri, MG, Lakoski, SG, Ainslie, P, Smirl, J, West, M, Lane, A, Coan, A, Ona, F, Klaunig, JE, Koceja, DM, Chapman, RF, and Jones, LW. "Autonomic and Cardiovascular Function of Hormone-Receptor Positive Breast Cancer Patients Following Treatment with Anthracycline-Containing Chemotherapy." MEDICINE AND SCIENCE IN SPORTS AND EXERCISE 44 (May 2012): 735-735.  Link to Item
    • Khouri, MG, Hornsby, W, Velazquez, EJ, Jones, LW, and Douglas, PS. "Exercise Stress Testing With Strain Echocardiography is Superior to Resting Echocardiography in Identifying Doxorubicin-Induced Preclinical LV Dysfunction in Breast Cancer Patients." CIRCULATION 124, no. 21 (November 22, 2011).  Link to Item
    • Khouri, MG, Peshock, RM, Ayers, CR, Lemos, JAD, and Drazner, MH. "A 4-tiered classification of left ventricular hypertrophy based on Left ventricular geometry the dallas Heart study." Circulation: Cardiovascular Imaging 3, no. 2 (2010): 164-171.  Full Text
    • Khouri, MG, Maurer, MS, and Rumbarger, LE-K. "Assessment of age-related changes in left ventricular structure and function by freehand three-dimensional echocardiography." The American journal of geriatric cardiology 14, no. 3 (2005): 118-125.

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