Overview
Basic-Translational:
1. Systems biology approaches to modeling perioperative cardiovascular injury and adaptation.
2. Mechanisms of perioperative myocardial injury; functional genomics applied to perioperative myocardial injury.
3. Metabolic consequences of perioperative myocardial ischemia-reperfusion injury.
4. Animal models and comparative genomic approaches to study perioperative myocardial ischemia-reperfusion injury.
5. Functional genomics of vein graft disease.
6. Animal models of vein graft disease.
7. Genetic association studies in perioperative medicine.
8. Clinico-genomic risk prediction models for perioperative and long-term adverse cardiovascular outcomes following cardiac surgery.
Clinical:
9. Intraoperative quantification of tissue perfusion by contrast echocardiography.
10. Use of myocardial tissue deformation indices to characterize perioperative ventricular dysfunction/stunning
11. 3-D echocardiographic evaluation of the right ventricle
1. Systems biology approaches to modeling perioperative cardiovascular injury and adaptation.
2. Mechanisms of perioperative myocardial injury; functional genomics applied to perioperative myocardial injury.
3. Metabolic consequences of perioperative myocardial ischemia-reperfusion injury.
4. Animal models and comparative genomic approaches to study perioperative myocardial ischemia-reperfusion injury.
5. Functional genomics of vein graft disease.
6. Animal models of vein graft disease.
7. Genetic association studies in perioperative medicine.
8. Clinico-genomic risk prediction models for perioperative and long-term adverse cardiovascular outcomes following cardiac surgery.
Clinical:
9. Intraoperative quantification of tissue perfusion by contrast echocardiography.
10. Use of myocardial tissue deformation indices to characterize perioperative ventricular dysfunction/stunning
11. 3-D echocardiographic evaluation of the right ventricle
Current Appointments & Affiliations
Associate Professor of Anesthesiology
·
2011 - Present
Anesthesiology, Cardiothoracic,
Anesthesiology
Chief, Division of Cardiac Anesthesiology
·
2013 - Present
Anesthesiology, Cardiothoracic,
Anesthesiology
Recent Publications
Evaluating Large Language Models for Automated Clinical Abstraction in Pulmonary Embolism Registries: Performance Across Model Sizes, Versions, and Parameters
Conference Lecture Notes in Computer Science · January 1, 2026 Pulmonary embolism (PE) registries accelerate practice-improving research but depend on resource-intensive manual abstraction of radiology reports. We evaluated whether openly available large-language models (LLMs) can automate concept extraction from comp ... Full text CiteRight Ventricle-Pulmonary Artery Coupling and Major Morbidity and Operative Mortality After Cardiac Surgery.
Journal Article Anesth Analg · October 1, 2025 BACKGROUND: The right ventricle-pulmonary artery (RV-PA) coupling ratio provides an assessment of RV function indexed to PA afterload. A low preoperative RV-PA ratio has been associated with increased mortality after transcatheter procedures. In patients u ... Full text Link to item CiteImpact of Point-of-care Allogeneic Red Blood Cell Washing on Markers of Transfusion-related Respiratory Complications: A Phase II Randomized Clinical Trial.
Journal Article Anesthesiology · July 1, 2025 BACKGROUND: Transfusion-related acute lung injury (TRALI) and transfusion-associated circulatory overload (TACO) are leading causes of transfusion-related morbidity and mortality. Soluble factors in erythrocyte supernatant may increase risk for these compl ... Full text Link to item CiteRecent Grants
Minimizing ICU Neurological Dysfunction with Dexmedetomidine-induced Sleep (MINDDS II)
ResearchPrincipal Investigator · Awarded by Massachusetts General Hospital · 2024 - 2029Patient-Focused Collaborative Hospital Repository Uniting Standards (CHoRUS) for Equitable AI
ResearchPrincipal Investigator · Awarded by Massachusetts General Hospital · 2022 - 2026Timely Response to In-Hospital Deterioration Through Design of Actionable Augmented Intelligence
ResearchPrincipal Investigator · Awarded by Idaho State University · 2020 - 2024View All Grants
Education, Training & Certifications
Carol Davila University of Medicine and Pharmacy (Romania) ·
1993
M.D.