Mihai V. Podgoreanu
Associate Professor of Anesthesiology
Basic-Translational:
1. Systems biology approaches to modeling perioperative cardiovascular injury and adaptation.
2. Mechanisms of perioperative myocardial injury; functional genomics applied to perioperative myocardial injury.
3. Metabolic consequences of perioperative myocardial ischemia-reperfusion injury.
4. Animal models and comparative genomic approaches to study perioperative myocardial ischemia-reperfusion injury.
5. Functional genomics of vein graft disease.
6. Animal models of vein graft disease.
7. Genetic association studies in perioperative medicine.
8. Clinico-genomic risk prediction models for perioperative and long-term adverse cardiovascular outcomes following cardiac surgery.
Clinical:
9. Intraoperative quantification of tissue perfusion by contrast echocardiography.
10. Use of myocardial tissue deformation indices to characterize perioperative ventricular dysfunction/stunning
11. 3-D echocardiographic evaluation of the right ventricle
1. Systems biology approaches to modeling perioperative cardiovascular injury and adaptation.
2. Mechanisms of perioperative myocardial injury; functional genomics applied to perioperative myocardial injury.
3. Metabolic consequences of perioperative myocardial ischemia-reperfusion injury.
4. Animal models and comparative genomic approaches to study perioperative myocardial ischemia-reperfusion injury.
5. Functional genomics of vein graft disease.
6. Animal models of vein graft disease.
7. Genetic association studies in perioperative medicine.
8. Clinico-genomic risk prediction models for perioperative and long-term adverse cardiovascular outcomes following cardiac surgery.
Clinical:
9. Intraoperative quantification of tissue perfusion by contrast echocardiography.
10. Use of myocardial tissue deformation indices to characterize perioperative ventricular dysfunction/stunning
11. 3-D echocardiographic evaluation of the right ventricle
Current Appointments & Affiliations
- Associate Professor of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2011
- Chief, Division of Cardiac Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2013
Contact Information
- Box 3094 DUMC, Durham, NC 27710
- Dumc, Anesthesiology Box 3094, Box 3094, Durham, NC 27710
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mihai.podgoreanu@duke.edu
(919) 812-0046
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Perioperative Genetics and Safety Outcomes Study (PEGASUS)
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Systems Modeling of Perioperative Cardiovascular Injury Laboratory
- Background
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Education, Training, & Certifications
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Previous Appointments & Affiliations
- Assistant Professor of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2003 - 2011
- Research
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Selected Grants
- Right ventricle adaptive changes in patients undergoing left ventricular assist device implantation awarded by Society of Cardiovascular Anesthesiologists 2021 - 2023
- Timely Response to In-Hospital Deterioration Through Design of Actionable Augmented Intelligence awarded by Idaho State University 2020 - 2023
- Allergan Botox II awarded by Allergan, Inc. 2019 - 2022
- Point-of-Care RBC Washing to Prevent Transfusion-Related Pulmonary Complications awarded by Mayo Clinic 2014 - 2020
- Interface of Mitochondrial Quality Control and Immune Activation in Heart Transplant awarded by Foundation for Anesthesia Education and Research 2018 - 2020
- Reversible Immunomodulation as a Strategy for Ischemia Tolerance in Hibernation awarded by Foundation for Anesthesia Education and Research 2017 - 2019
- Acute Inflammation, Fibrosis in Post Operative Atrial Fibrillation awarded by International Anesthesia Research Society 2015 - 2017
- Innate immune adaptations of hibernation as a new approach to protection against acute organ injury awarded by Society of Cardiovascular Anesthesiologists 2015 - 2017
- Development of Biomarkers of Aging as a Predictor of AKI Due to Cardiac Surgery awarded by HealthSpan 2015 - 2016
- Cross-species analysis of myocardial susceptibility to perioperative stress awarded by National Institutes of Health 2007 - 2013
- Genetics Myocardial Adverse Outcomes/Graft Failure-CABG (Gene-Magic) awarded by National Institutes of Health 2004 - 2011
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Lascola, Christopher D., Sarah F. Cotter, Rebecca Y. Klinger, Tiffany Bisanar, Mary Cooter Wright, Miles Berger, Gavin Martin, et al. “Blood-brain barrier permeability and cognitive dysfunction after surgery - A pilot study.” J Clin Anesth 86 (June 2023): 111059. https://doi.org/10.1016/j.jclinane.2023.111059.Full Text Link to Item
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Nicoara, Alina, Mary Cooter Wright, Daniel Rosenkrans, Chetan B. Patel, Jacob N. Schroder, Anne D. Cherry, Nazish K. Hashmi, et al. “Predictive capabilities of the European registry for patients with mechanical circulatory support right-sided heart failure risk score after left ventricular assist device implantation.” J Cardiothorac Vasc Anesth 36, no. 10 (October 2022): 3740–46. https://doi.org/10.1053/j.jvca.2022.06.022.Full Text Link to Item
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Podgoreanu, Mihai V., and Negmeldeen Mamoun. “Albumin vs Crystalloid Fluid for Resuscitation in Cardiac Surgery: New Evidence and Arguments in the Timeless Debate.” Jama 328, no. 3 (July 19, 2022): 246–48. https://doi.org/10.1001/jama.2022.10113.Full Text Link to Item
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Manning, Michael W., Yi-Ju Li, Dean Linder, John C. Haney, Yi-Hung Wu, Mihai V. Podgoreanu, Madhav Swaminathan, et al. “Conventional Ultrafiltration During Elective Cardiac Surgery and Postoperative Acute Kidney Injury.” J Cardiothorac Vasc Anesth 35, no. 5 (May 2021): 1310–18. https://doi.org/10.1053/j.jvca.2020.11.036.Full Text Link to Item
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Welsby, Ian J., Philip J. Norris, William J. Mauermann, Mihai V. Podgoreanu, Chelsea M. Conn, Laurie Meade, Tamara Cannon, et al. “Bedside Allogeneic Erythrocyte Washing with a Cell Saver to Remove Cytokines, Chemokines, and Cell-derived Microvesicles.” Anesthesiology 134, no. 3 (March 1, 2021): 395–404. https://doi.org/10.1097/ALN.0000000000003689.Full Text Link to Item
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Privratsky, Jamie R., Yi-Ju Li, Carol Haynes, Mihai Podgoreanu, Joseph Mathew, Svati H. Shah, and Mark Stafford-Smith. “Apolipoprotein L1 (APOL1) Coding Variants Are Associated With Creatinine Rise After Cardiac Surgery.” J Cardiothorac Vasc Anesth 34, no. 12 (December 2020): 3314–20. https://doi.org/10.1053/j.jvca.2020.04.017.Full Text Link to Item
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Nicoara, Alina, Adam Kretzer, Mary Cooter, Raquel Bartz, Jeffrey Lyvers, Chetan B. Patel, Jacob N. Schroder, et al. “Association between primary graft dysfunction and acute kidney injury after orthotopic heart transplantation - a retrospective, observational cohort study.” Transpl Int 33, no. 8 (August 2020): 887–94. https://doi.org/10.1111/tri.13615.Full Text Link to Item
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Fudim, Marat, Yawar J. Qadri, Nathan H. Waldron, Richard L. Boortz-Marx, Arun Ganesh, Chetan B. Patel, Mihai V. Podgoreanu, et al. “Stellate Ganglion Blockade for the Treatment of Refractory Ventricular Arrhythmias.” Jacc Clin Electrophysiol 6, no. 5 (May 2020): 562–71. https://doi.org/10.1016/j.jacep.2019.12.017.Full Text Link to Item
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Podgoreanu, Mihai V., Michael J. Devinney, and Joseph P. Mathew. “Oxidative Stress Response and Delirium after Cardiac Surgery: Can Circulating Biomarkers Refine New Therapeutic Paradigms?” Anesthesiology 132, no. 3 (March 2020): 418–20. https://doi.org/10.1097/ALN.0000000000003097.Full Text Link to Item
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Klinger, Rebecca Y., Mary Cooter, Tiffany Bisanar, Niccolò Terrando, Miles Berger, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, Joseph P. Mathew, and Joseph P. Neurologic Outcomes Research Group of the Duke Heart Center. “Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.” Anesthesiology 130, no. 6 (June 2019): 958–70. https://doi.org/10.1097/ALN.0000000000002668.Full Text Link to Item
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Suarez-Roca, Heberto, Rebecca Y. Klinger, Mihai V. Podgoreanu, Ru-Rong Ji, Martin I. Sigurdsson, Nathan Waldron, Joseph P. Mathew, and William Maixner. “Contribution of Baroreceptor Function to Pain Perception and Perioperative Outcomes.” Anesthesiology 130, no. 4 (April 2019): 634–50. https://doi.org/10.1097/ALN.0000000000002510.Full Text Link to Item
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Barac, Yaron D., Dominick J. Megna, Anthony W. Castleberry, Jacob N. Schroder, Mani A. Daneshmand, Joseph G. Rogers, Chetan B. Patel, Mihai Podgoreanu, and Carmelo A. Milano. “Transplanting a heart with a persistent left superior vena cava.” J Thorac Cardiovasc Surg 157, no. 2 (February 2019): 630–31. https://doi.org/10.1016/j.jtcvs.2018.07.109.Full Text Link to Item
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Waldron, Nathan H., Mary Cooter, John C. Haney, Jacob N. Schroder, Jeffrey G. Gaca, Shu S. Lin, Martin I. Sigurdsson, et al. “Temporary autonomic modulation with botulinum toxin type A to reduce atrial fibrillation after cardiac surgery.” Heart Rhythm 16, no. 2 (February 2019): 178–84. https://doi.org/10.1016/j.hrthm.2018.08.021.Full Text Link to Item
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Ma, Qing, Zhiquan Zhang, Jae-Kwang Shim, Talaignair N. Venkatraman, Christopher D. Lascola, Quintin J. Quinones, Joseph P. Mathew, Niccolò Terrando, and Mihai V. Podgoreanu. “Annexin A1 Bioactive Peptide Promotes Resolution of Neuroinflammation in a Rat Model of Exsanguinating Cardiac Arrest Treated by Emergency Preservation and Resuscitation.” Front Neurosci 13 (2019): 608. https://doi.org/10.3389/fnins.2019.00608.Full Text Link to Item
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Waldron, Nathan H., Mary Cooter, Jonathan P. Piccini, Kevin J. Anstrom, Rebecca Y. Klinger, Miklos D. Kertai, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, and Joseph P. Mathew. “Predictive ability of perioperative atrial fibrillation risk indices in cardiac surgery patients: a retrospective cohort study.” Can J Anaesth 65, no. 7 (July 2018): 786–96. https://doi.org/10.1007/s12630-018-1119-x.Full Text Link to Item
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Nicoara, Alina, David Ruffin, Mary Cooter, Chetan B. Patel, Annemarie Thompson, Jacob N. Schroder, Mani A. Daneshmand, et al. “Primary graft dysfunction after heart transplantation: Incidence, trends, and associated risk factors.” Am J Transplant 18, no. 6 (June 2018): 1461–70. https://doi.org/10.1111/ajt.14588.Full Text Link to Item
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Oprea, Adriana D., J Mauricio Del Rio, Mary Cooter, Cynthia L. Green, Jörn A. Karhausen, Patrick Nailer, Nicole R. Guinn, et al. “Pre- and postoperative anemia, acute kidney injury, and mortality after coronary artery bypass grafting surgery: a retrospective observational study.” Can J Anaesth 65, no. 1 (January 2018): 46–59. https://doi.org/10.1007/s12630-017-0991-0.Full Text Link to Item
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Karhausen, Jörn A., Alan M. Smeltz, Igor Akushevich, Mary Cooter, Mihai V. Podgoreanu, Mark Stafford-Smith, Susan M. Martinelli, Manuel L. Fontes, and Miklos D. Kertai. “Platelet Counts and Postoperative Stroke After Coronary Artery Bypass Grafting Surgery.” Anesth Analg 125, no. 4 (October 2017): 1129–39. https://doi.org/10.1213/ANE.0000000000002187.Full Text Open Access Copy Link to Item
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Manning, Michael W., Mary Cooter, Joseph Mathew, John Alexander, Eric Peterson, T Bruce Ferguson, Renato Lopes, and Mihai Podgoreanu. “Angiotensin Receptor Blockade Improves Cardiac Surgical Outcomes in Patients With Metabolic Syndrome.” Ann Thorac Surg 104, no. 1 (July 2017): 98–105. https://doi.org/10.1016/j.athoracsur.2016.10.021.Full Text Link to Item
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Diepen, Sean van, Peter D. Merrill, Michel Carrier, Jean-Claude Tardif, Mihai Podgoreanu, John H. Alexander, and Renato D. Lopes. “Association between CK-MB Area Under the Curve and Tranexamic Acid Utilization in Patients Undergoing Coronary Artery Bypass Surgery.” J Thromb Thrombolysis 43, no. 4 (May 2017): 446–53. https://doi.org/10.1007/s11239-017-1480-6.Full Text Open Access Copy Link to Item
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Zhang, Zhiquan, Qing Ma, Bijal Shah, G Burkhard Mackensen, Donald C. Lo, Joseph P. Mathew, Mihai V. Podgoreanu, and Niccolò Terrando. “Neuroprotective Effects of Annexin A1 Tripeptide after Deep Hypothermic Circulatory Arrest in Rats.” Front Immunol 8 (2017): 1050. https://doi.org/10.3389/fimmu.2017.01050.Full Text Link to Item
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Klinger, Rebecca Y., Mary Cooter, Miles Berger, Mihai V. Podgoreanu, Mark Stafford-Smith, Thomas L. Ortel, Ian J. Welsby, et al. “Effect of intravenous lidocaine on the transcerebral inflammatory response during cardiac surgery: a randomized-controlled trial.” Can J Anaesth 63, no. 11 (November 2016): 1223–32. https://doi.org/10.1007/s12630-016-0704-0.Full Text Link to Item
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Kertai, Miklos D., Shan Zhou, Jörn A. Karhausen, Mary Cooter, Edmund Jooste, Yi-Ju Li, William D. White, et al. “In Reply.” Anesthesiology 125, no. 2 (August 2016): 438–39. https://doi.org/10.1097/ALN.0000000000001190.Full Text Link to Item
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Quinones, Quintin J., Zhiquan Zhang, Qing Ma, Michael P. Smith, Erik Soderblom, M Arthur Moseley, James Bain, et al. “Proteomic Profiling Reveals Adaptive Responses to Surgical Myocardial Ischemia-Reperfusion in Hibernating Arctic Ground Squirrels Compared to Rats.” Anesthesiology 124, no. 6 (June 2016): 1296–1310. https://doi.org/10.1097/ALN.0000000000001113.Full Text Link to Item
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Kertai, Miklos D., Yunqi Ji, Yi-Ju Li, Joseph P. Mathew, James P. Daubert, Mihai V. Podgoreanu, and Mihai V. PEGASUS Investigative Team. “Interleukin-1β gene variants are associated with QTc interval prolongation following cardiac surgery: a prospective observational study.” Can J Anaesth 63, no. 4 (April 2016): 397–410. https://doi.org/10.1007/s12630-015-0576-8.Full Text Link to Item
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Kertai, Miklos D., Wenjing Qi, Yi-Ju Li, Frederick W. Lombard, Yutao Liu, Michael P. Smith, Mark Stafford-Smith, et al. “Gene signatures of postoperative atrial fibrillation in atrial tissue after coronary artery bypass grafting surgery in patients receiving β-blockers.” J Mol Cell Cardiol 92 (March 2016): 109–15. https://doi.org/10.1016/j.yjmcc.2016.02.006.Full Text Link to Item
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Kertai, Miklos D., Shan Zhou, Jörn A. Karhausen, Mary Cooter, Edmund Jooste, Yi-Ju Li, William D. White, et al. “Platelet Counts, Acute Kidney Injury, and Mortality after Coronary Artery Bypass Grafting Surgery.” Anesthesiology 124, no. 2 (February 2016): 339–52. https://doi.org/10.1097/ALN.0000000000000959.Full Text Open Access Copy Link to Item
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Klinger, Rebecca Y., Christopher A. Thunberg, William D. White, Manuel Fontes, Nathan H. Waldron, Jonathan P. Piccini, G Chad Hughes, et al. “Intraoperative Magnesium Administration Does Not Reduce Postoperative Atrial Fibrillation After Cardiac Surgery.” Anesth Analg 121, no. 4 (October 2015): 861–67. https://doi.org/10.1213/ANE.0000000000000873.Full Text Link to Item
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Stafford-Smith, Mark, Yi-Ju Li, Joseph P. Mathew, Yen-Wei Li, Yunqi Ji, Barbara G. Phillips-Bute, Carmelo A. Milano, et al. “Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci.” Kidney Int 88, no. 4 (October 2015): 823–32. https://doi.org/10.1038/ki.2015.161.Full Text Open Access Copy Link to Item
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Kertai, Miklos D., Yi-Ju Li, Yunqi Ji, Wenjing Qi, Frederick W. Lombard, Svati H. Shah, William E. Kraus, et al. “Genome-wide association study of new-onset atrial fibrillation after coronary artery bypass grafting surgery.” Am Heart J 170, no. 3 (September 2015): 580-90.e28. https://doi.org/10.1016/j.ahj.2015.06.009.Full Text Link to Item
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Bartels, Karsten, Yi-Ju Li, Yen-Wei Li, William D. White, Daniel T. Laskowitz, Miklos D. Kertai, Mark Stafford-Smith, Mihai V. Podgoreanu, Mark F. Newman, and Joseph P. Mathew. “Apolipoprotein epsilon 4 genotype is associated with less improvement in cognitive function five years after cardiac surgery: a retrospective cohort study.” Can J Anaesth 62, no. 6 (June 2015): 618–26. https://doi.org/10.1007/s12630-015-0337-8.Full Text Link to Item
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Kertai, Miklos D., Yi-Ju Li, Yen-Wei Li, Yunqi Ji, John Alexander, Mark F. Newman, Peter K. Smith, et al. “Genome-wide association study of perioperative myocardial infarction after coronary artery bypass surgery.” Bmj Open 5, no. 5 (May 6, 2015): e006920. https://doi.org/10.1136/bmjopen-2014-006920.Full Text Open Access Copy Link to Item
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Bartels, Karsten, Qing Ma, Talaignair N. Venkatraman, Christopher R. Campos, Lindsay Smith, Ronald E. Cannon, Mihai V. Podgoreanu, Christopher D. Lascola, David S. Miller, and Joseph P. Mathew. “Effects of deep hypothermic circulatory arrest on the blood brain barrier in a cardiopulmonary bypass model--a pilot study.” Heart Lung Circ 23, no. 10 (October 2014): 981–84. https://doi.org/10.1016/j.hlc.2014.04.131.Full Text Link to Item
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Quinones, Quintin J., Qing Ma, Zhiquan Zhang, Brian M. Barnes, and Mihai V. Podgoreanu. “Organ protective mechanisms common to extremes of physiology: a window through hibernation biology.” Integr Comp Biol 54, no. 3 (September 2014): 497–515. https://doi.org/10.1093/icb/icu047.Full Text Link to Item
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Shim, Jae-Kwang, Qing Ma, Zhiquan Zhang, Mihai V. Podgoreanu, and G Burkhard Mackensen. “Effect of pregabalin on cerebral outcome after cardiopulmonary bypass with deep hypothermic circulatory arrest in rats.” J Thorac Cardiovasc Surg 148, no. 1 (July 2014): 298–303. https://doi.org/10.1016/j.jtcvs.2014.02.076.Full Text Link to Item
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Fontes, Monique T., David L. McDonagh, Barbara Phillips-Bute, Ian J. Welsby, Mihai V. Podgoreanu, Manuel L. Fontes, Mark Stafford-Smith, Mark F. Newman, Joseph P. Mathew, and Joseph P. Neurologic Outcome Research Group (NORG) of the Duke Heart Center. “Arterial hyperoxia during cardiopulmonary bypass and postoperative cognitive dysfunction.” J Cardiothorac Vasc Anesth 28, no. 3 (June 2014): 462–66. https://doi.org/10.1053/j.jvca.2013.03.034.Full Text Link to Item
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Kertai, Miklos D., Stephen A. Esper, Igor Akushevich, Deepak Voora, Geoffrey S. Ginsburg, Mark Stafford-Smith, Katherine Grichnik, et al. “Preoperative CYP2D6 metabolism-dependent β-blocker use and mortality after coronary artery bypass grafting surgery.” J Thorac Cardiovasc Surg 147, no. 4 (April 2014): 1368-1375.e3. https://doi.org/10.1016/j.jtcvs.2013.09.067.Full Text Open Access Copy Link to Item
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Nelson, Charlotte L., Kimberly Pelak, Mihai V. Podgoreanu, Sun Hee Ahn, William K. Scott, Andrew S. Allen, Lindsay G. Cowell, et al. “A genome-wide association study of variants associated with acquisition of Staphylococcus aureus bacteremia in a healthcare setting.” Bmc Infect Dis 14 (February 13, 2014): 83. https://doi.org/10.1186/1471-2334-14-83.Full Text Open Access Copy Link to Item
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Mathew, Joseph P., William D. White, David B. Schinderle, Mihai V. Podgoreanu, Miles Berger, Carmelo A. Milano, Daniel T. Laskowitz, et al. “Intraoperative magnesium administration does not improve neurocognitive function after cardiac surgery.” Stroke 44, no. 12 (December 2013): 3407–13. https://doi.org/10.1161/STROKEAHA.113.002703.Full Text Link to Item
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Podgoreanu, M. V. “Perioperative Genomics” 2 (August 29, 2013): 635–54. https://doi.org/10.1016/B978-0-12-382227-7.00055-0.Full Text
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Riess, Matthias L., and Mihai V. Podgoreanu. “Intralipid: the new magic bullet in cardioprotection?” Anesthesiology 118, no. 5 (May 2013): 1237–38. https://doi.org/10.1097/ALN.0b013e31828bac35.Full Text Link to Item
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Fontes, Monique T., R Cameron Swift, Barbara Phillips-Bute, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, Joseph P. Mathew, and Joseph P. Neurologic Outcome Research Group of the Duke Heart Center. “Predictors of cognitive recovery after cardiac surgery.” Anesth Analg 116, no. 2 (February 2013): 435–42. https://doi.org/10.1213/ANE.0b013e318273f37e.Full Text Link to Item
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Kertai, Miklos D., Manuel Fontes, and Mihai V. Podgoreanu. “Pharmacogenomics of β-blockers and statins: possible implications for perioperative cardiac complications.” J Cardiothorac Vasc Anesth 26, no. 6 (December 2012): 1101–14. https://doi.org/10.1053/j.jvca.2012.06.025.Full Text Link to Item
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Marcucci, Carlo E., Zainab Samad, Jose Rivera, David B. Adams, Barbara G. Philips-Bute, Aman Mahajan, Pamela S. Douglas, et al. “A comparative evaluation of transesophageal and transthoracic echocardiography for measurement of left ventricular systolic strain using speckle tracking.” J Cardiothorac Vasc Anesth 26, no. 1 (February 2012): 17–25. https://doi.org/10.1053/j.jvca.2011.06.002.Full Text Link to Item
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Podgoreanu, Mihai V., Qing Ma, G. B. Mackensen, Zhiquan Zhang, Michael P. Smith, James Bain, Christopher B. Newgard, Franziska Kohl, Kelly L. Drew, and Brian M. Barnes. “The Hibernator Metabolic Phenotype is Cardioprotective in the Setting of Deep Hypothermic Circulatory Arrest.” Circulation 124, no. 21 (November 22, 2011).Link to Item
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Zhang, Zhiquan, Qing Ma, G. B. Mackensen, and Mihai V. Podgoreanu. “Annexin-A1 Interacts With NF-KappaB Inhibiting Its Activation: Cardioprotection in vivo and in vitro.” Circulation 124, no. 21 (November 22, 2011).Link to Item
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D’Alonzo, Richard C., Elliott Bennett-Guerrero, Mihai Podgoreanu, Thomas A. D’Amico, David H. Harpole, and Andrew D. Shaw. “A randomized, double blind, placebo controlled clinical trial of the preoperative use of ketamine for reducing inflammation and pain after thoracic surgery.” J Anesth 25, no. 5 (October 2011): 672–78. https://doi.org/10.1007/s00540-011-1206-4.Full Text Link to Item
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Lobato, Robert L., William D. White, Joseph P. Mathew, Mark F. Newman, Peter K. Smith, Charles B. McCants, John H. Alexander, Mihai V. Podgoreanu, and Mihai V. Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team. “Thrombomodulin gene variants are associated with increased mortality after coronary artery bypass surgery in replicated analyses.” Circulation 124, no. 11 Suppl (September 13, 2011): S143–48. https://doi.org/10.1161/CIRCULATIONAHA.110.008334.Full Text Link to Item
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Leff, Jonathan D., Hilcias Duran, Liza Enriquez, Joseph DeRose, Linda Shore-Lesserson, Jerry H. Kim, Debra A. Schwinn, Mihai V. Podgoreanu, and Henry Rosenberg. “Case 4-2011: malignant hyperthermia in cardiac surgery.” J Cardiothorac Vasc Anesth 25, no. 4 (August 2011): 731–35. https://doi.org/10.1053/j.jvca.2011.01.013.Full Text Link to Item
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Swaminathan, Madhav, Alina Nicoara, Barbara G. Phillips-Bute, Nicolas Aeschlimann, Carmelo A. Milano, G Burkhard Mackensen, Mihai V. Podgoreanu, et al. “Utility of a simple algorithm to grade diastolic dysfunction and predict outcome after coronary artery bypass graft surgery.” Ann Thorac Surg 91, no. 6 (June 2011): 1844–50. https://doi.org/10.1016/j.athoracsur.2011.02.008.Full Text Link to Item
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D’Alonzo, R. C., E. Bennett-Guerrero, M. Podgoreanu, T. A. D’Amico, D. H. Harpole, and A. D. Shaw. “A randomized, double blind, placebo controlled clinical trial of the preoperative use of ketamine for reducing inflammation and pain after thoracic surgery.” Journal of Anesthesia, 2011, 1–7.
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Lobato, Robert L., William D. White, Joseph P. Mathew, Mark F. Newman, John H. Alexander, and Mihai V. Podgoreanu. “Thrombomodulin Variants are Associated with Increased Mortality following CABG Surgery in Replicated Analyses.” Circulation 122, no. 21 (November 23, 2010).Link to Item
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Podgoreanu, Mihai V., Sheng Feng, Gail Hafley, Mark Donahue, C. M. Gibson, Debra A. Schwinn, and John H. Alexander. “Genome-wide Association Study of Vein Graft Disease Following Coronary Artery Bypass Surgery.” Circulation 122, no. 21 (November 23, 2010).Link to Item
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Zhang, Zhiquan, Qing Ma, James Frederiksen, George Quick, Kevin Collins, Burkhard Mckensen, and Mihai Podgoreanu. “Annexin-a1 Tripeptide is Cardioprotective in Several Preclinical Models of Ischemia-Reperfusion Through Resolution of Myocardial Inflammation.” Circulation 122, no. 21 (November 23, 2010).Link to Item
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Turer, Aslan T., Craig R. Malloy, Christopher B. Newgard, and Mihai V. Podgoreanu. “Energetics and metabolism in the failing heart: important but poorly understood.” Curr Opin Clin Nutr Metab Care 13, no. 4 (July 2010): 458–65. https://doi.org/10.1097/MCO.0b013e32833a55a5.Full Text Link to Item
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Welsby, Ian J., Mihai V. Podgoreanu, Barbara Phillips-Bute, Richard Morris, Joseph P. Mathew, Peter K. Smith, Mark F. Newman, Debra A. Schwinn, Mark Stafford-Smith, and Mark Perioperative Genetics and Safety Outcomes Study Investigative Team. “Association of the 98T ELAM-1 polymorphism with increased bleeding after cardiac surgery.” J Cardiothorac Vasc Anesth 24, no. 3 (June 2010): 427–33. https://doi.org/10.1053/j.jvca.2009.10.030.Full Text Link to Item
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Heinzen, Erin L., Rodney A. Radtke, Thomas J. Urban, Gianpiero L. Cavalleri, Chantal Depondt, Anna C. Need, Nicole M. Walley, et al. “Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes.” Am J Hum Genet 86, no. 5 (May 14, 2010): 707–18. https://doi.org/10.1016/j.ajhg.2010.03.018.Full Text Link to Item
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Nikolov, Nikolay M., Manuel L. Fontes, William D. White, Solomon Aronson, Shahar Bar-Yosef, Jeffrey G. Gaca, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, and Joseph P. Mathew. “Pulse pressure and long-term survival after coronary artery bypass graft surgery.” Anesth Analg 110, no. 2 (February 1, 2010): 335–40. https://doi.org/10.1213/ANE.0b013e3181c76f87.Full Text Link to Item
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Body, S. C., M. V. Podgoreanu, and D. A. Schwinn. “Genomics of Perioperative and Procedural Medicine,” December 1, 2009, 794–805. https://doi.org/10.1016/B978-0-12-369420-1.00066-4.Full Text
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Turer, Aslan T., Robert D. Stevens, James R. Bain, Michael J. Muehlbauer, Johannes van der Westhuizen, Joseph P. Mathew, Debra A. Schwinn, Donald D. Glower, Christopher B. Newgard, and Mihai V. Podgoreanu. “Metabolomic profiling reveals distinct patterns of myocardial substrate use in humans with coronary artery disease or left ventricular dysfunction during surgical ischemia/reperfusion.” Circulation 119, no. 13 (April 7, 2009): 1736–46. https://doi.org/10.1161/CIRCULATIONAHA.108.816116.Full Text Link to Item
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Akhtar, S., M. Podgoreanu, B. A. Harrison, and S. J. Brull. “Effect of lidocaine on endothelin-1-mediated airway smooth muscle contraction in the rat trachea.” Minerva Anestesiol 74, no. 11 (November 2008): 643–50.Link to Item
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Phillips-Bute, Barbara, Joseph P. Mathew, James A. Blumenthal, Richard W. Morris, Mihai V. Podgoreanu, Michael Smith, Mark Stafford-Smith, et al. “Relationship of genetic variability and depressive symptoms to adverse events after coronary artery bypass graft surgery.” Psychosom Med 70, no. 9 (November 2008): 953–59. https://doi.org/10.1097/PSY.0b013e318187aee6.Full Text Link to Item
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Lange, Fellery de, Kenji Yoshitani, Mihai V. Podgoreanu, Hilary P. Grocott, and G Burkhard Mackensen. “A novel survival model of cardioplegic arrest and cardiopulmonary bypass in rats: a methodology paper.” J Cardiothorac Surg 3 (August 19, 2008): 51. https://doi.org/10.1186/1749-8090-3-51.Full Text Link to Item
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Martinelli, Susan M., John D. Mitchell, Richard L. McCann, Mihai V. Podgoreanu, Joseph P. Mathew, and Madhav Swaminathan. “Intraoperative transesophageal echocardiography diagnosis of residual tumor fragment after surgical removal of renal cell carcinoma.” Anesth Analg 106, no. 6 (June 2008): 1633–35. https://doi.org/10.1213/ane.0b013e3181734147.Full Text Link to Item
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Schwinn, Debra A., and Mihai Podgoreanu. “Pharmacogenomics and end-organ susceptibility to injury in the perioperative period.” Best Pract Res Clin Anaesthesiol 22, no. 1 (March 2008): 23–37. https://doi.org/10.1016/j.bpa.2007.09.005.Full Text Link to Item
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Nicoara, Alina, G Burkhard Mackensen, Mihai V. Podgoreanu, Carmelo A. Milano, Joseph P. Mathew, and Madhav Swaminathan. “Malpositioned left ventricular assist device cannula: diagnosis and management with transesophageal echocardiography guidance.” Anesth Analg 105, no. 6 (December 2007): 1574–76. https://doi.org/10.1213/01.ane.0000286065.39763.bc.Full Text Link to Item
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Swaminathan, Madhav, Richard W. Morris, Daniel D. De Meyts, Mihai V. Podgoreanu, James G. Jollis, Hilary P. Grocott, Carmelo A. Milano, Mark F. Newman, and Joseph P. Mathew. “Deterioration of regional wall motion immediately after coronary artery bypass graft surgery is associated with long-term major adverse cardiac events.” Anesthesiology 107, no. 5 (November 2007): 739–45. https://doi.org/10.1097/01.anes.0000287008.70453.81.Full Text Link to Item
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Podgoreanu, Mihai V., Kenji Yoshitani, Adrian Dobra, Oing Ma, Bin Zhu, and G. B. Mackensen. “Comparative gene expression analysis of blood and heart identifies genomic predictors of myocardial injury following cardiopulmonary bypass and cardioplegic arrest in the rat.” Circulation 116, no. 16 (October 16, 2007): 323–323.Link to Item
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Mathew, Joseph P., G Burkhard Mackensen, Barbara Phillips-Bute, Mark Stafford-Smith, Mihai V. Podgoreanu, Hilary P. Grocott, Steven E. Hill, et al. “Effects of extreme hemodilution during cardiac surgery on cognitive function in the elderly.” Anesthesiology 107, no. 4 (October 2007): 577–84. https://doi.org/10.1097/01.anes.0000281896.07256.71.Full Text Link to Item
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Swaminathan, Madhav, Hilary P. Grocott, G Burkhard Mackensen, Mihai V. Podgoreanu, Donald D. Glower, and Joseph P. Mathew. “The "sandblasting" effect of aortic cannula on arch atheroma during cardiopulmonary bypass.” Anesth Analg 104, no. 6 (June 2007): 1350–51. https://doi.org/10.1213/01.ane.0000264090.24756.08.Full Text Link to Item
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Mathew, Joseph P., Mihai V. Podgoreanu, Hilary P. Grocott, William D. White, Richard W. Morris, Mark Stafford-Smith, G Burkhard Mackensen, et al. “Genetic variants in P-selectin and C-reactive protein influence susceptibility to cognitive decline after cardiac surgery.” J Am Coll Cardiol 49, no. 19 (May 15, 2007): 1934–42. https://doi.org/10.1016/j.jacc.2007.01.080.Full Text Link to Item
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Swaminathan, Madhav, Georg B. Mackensen, Mihai V. Podgoreanu, Richard L. McCann, Joseph P. Mathew, and George C. Hughes. “Spontaneous echocardiographic contrast indicating successful endoleak management.” Anesth Analg 104, no. 5 (May 2007): 1037–39. https://doi.org/10.1213/01.ane.0000263269.68845.83.Full Text Link to Item
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Podgoreanu, M. V., W. D. White, R. W. Morris, J. P. Mathew, M. Stafford-Smith, I. J. Welsby, H. P. Grocott, et al. “Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.” Circulation 114, no. 1 Suppl (July 4, 2006): I275–81. https://doi.org/10.1161/CIRCULATIONAHA.105.001032.Full Text Link to Item
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Izrailtyan, Igor, Jeffrey Clark, Madhav Swaminathan, Mihai V. Podgoreanu, Burkhard Mackensen, R Duane Davis, and Joseph P. Mathew. “Case report: optimizing intraoperative detection of pulmonary embolism using contrast-enhanced echocardiography.” Can J Anaesth 53, no. 7 (July 2006): 711–15. https://doi.org/10.1007/BF03021630.Full Text Link to Item
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Podgoreanu, Mihai V., and Joseph P. Mathew. “Prophylaxis against postoperative atrial fibrillation: current progress and future directions.” Jama 294, no. 24 (December 28, 2005): 3140–42. https://doi.org/10.1001/jama.294.24.3140.Full Text Link to Item
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Podgoreanu, Mihai V., and Debra A. Schwinn. “New paradigms in cardiovascular medicine: emerging technologies and practices: perioperative genomics.” J Am Coll Cardiol 46, no. 11 (December 6, 2005): 1965–77. https://doi.org/10.1016/j.jacc.2005.08.040.Full Text Link to Item
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Moretti, Eugene W., Richard W. Morris, Mihai Podgoreanu, Debra A. Schwinn, Mark F. Newman, Ellen Bennett, Victor G. Moulin, Uzo U. Mba, Daniel T. Laskowitz, and Daniel T. Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. “APOE polymorphism is associated with risk of severe sepsis in surgical patients.” Crit Care Med 33, no. 11 (November 2005): 2521–26. https://doi.org/10.1097/01.ccm.0000186368.96146.fb.Full Text Link to Item
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Grocott, Hilary P., William D. White, Richard W. Morris, Mihai V. Podgoreanu, Joseph P. Mathew, Dahlia M. Nielsen, Debra A. Schwinn, Mark F. Newman, and Mark F. Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. “Genetic polymorphisms and the risk of stroke after cardiac surgery.” Stroke 36, no. 9 (September 2005): 1854–58. https://doi.org/10.1161/01.STR.0000177482.23478.dc.Full Text Link to Item
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Podgoreanu, Mihai V., Gregory A. Michelotti, Yukie Sato, Michael P. Smith, Simon Lin, Richard W. Morris, Hilary P. Grocott, Joseph P. Mathew, and Debra A. Schwinn. “Differential cardiac gene expression during cardiopulmonary bypass: ischemia-independent upregulation of proinflammatory genes.” J Thorac Cardiovasc Surg 130, no. 2 (August 2005): 330–39. https://doi.org/10.1016/j.jtcvs.2004.11.052.Full Text Link to Item
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Schwinn, D. A., and M. Podgoreanu. “The new age of medical genomics.” Br J Anaesth 95, no. 2 (August 2005): 119–21. https://doi.org/10.1093/bja/aei159.Full Text Link to Item
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Mathew, Joseph P., Hilary P. Grocott, James R. McCurdy, Lian K. Ti, R Duane Davis, Daniel T. Laskowitz, Mihai V. Podgoreanu, et al. “Preoperative statin therapy does not reduce cognitive dysfunction after cardiopulmonary bypass.” J Cardiothorac Vasc Anesth 19, no. 3 (June 2005): 294–99. https://doi.org/10.1053/j.jvca.2005.03.004.Full Text Link to Item
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Welsby, I. J., M. V. Podgoreanu, B. Phillips-Bute, J. P. Mathew, P. K. Smith, M. F. Newman, D. A. Schwinn, M. Stafford-Smith, and M. Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. “Genetic factors contribute to bleeding after cardiac surgery.” J Thromb Haemost 3, no. 6 (June 2005): 1206–12. https://doi.org/10.1111/j.1538-7836.2005.01337.x.Full Text Link to Item
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Stafford-Smith, Mark, Mihai Podgoreanu, Madhav Swaminathan, Barbara Phillips-Bute, Joseph P. Mathew, Elizabeth H. Hauser, Michelle P. Winn, et al. “Association of genetic polymorphisms with risk of renal injury after coronary bypass graft surgery.” Am J Kidney Dis 45, no. 3 (March 2005): 519–30. https://doi.org/10.1053/j.ajkd.2004.11.021.Full Text Link to Item
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McKinlay, Kenneth H., David B. Schinderle, Madhav Swaminathan, Mihai V. Podgoreanu, Carmelo A. Milano, Robert H. Messier, Habib El-Moalem, Mark F. Newman, Fiona M. Clements, and Joseph P. Mathew. “Predictors of inotrope use during separation from cardiopulmonary bypass.” J Cardiothorac Vasc Anesth 18, no. 4 (August 2004): 404–8. https://doi.org/10.1053/j.jvca.2004.05.015.Full Text Link to Item
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Podgoreanu, M. V., and D. A. Schwinn. “Genomics and the circulation.” Br J Anaesth 93, no. 1 (July 2004): 140–48. https://doi.org/10.1093/bja/aeh168.Full Text Link to Item
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Djaiani, George, Barbara Phillips-Bute, Mihai Podgoreanu, Robert H. Messier, Joseph P. Mathew, Fiona Clements, and Mark F. Newman. “The association of patent foramen ovale and atrial fibrillation after coronary artery bypass graft surgery.” Anesth Analg 98, no. 3 (March 2004): 585–89. https://doi.org/10.1213/01.ane.0000099721.67426.de.Full Text Link to Item
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Booth, John V., Barbara Phillips-Bute, Charles B. McCants, Mihai V. Podgoreanu, Peter K. Smith, Joseph P. Mathew, and Mark F. Newman. “Low serum magnesium level predicts major adverse cardiac events after coronary artery bypass graft surgery.” Am Heart J 145, no. 6 (June 2003): 1108–13. https://doi.org/10.1016/S0002-8703(03)00077-2.Full Text Link to Item
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Podgoreanu, Mihai V., George N. Djaiani, Elizabeth Davis, Barbara Phillips-Bute, and Joseph P. Mathew. “Quantitative echocardiographic assessment of regional wall motion and left ventricular asynchrony with color kinesis in cardiac surgery patients.” Anesth Analg 96, no. 5 (May 2003): 1294–1300. https://doi.org/10.1213/01.ANE.0000056826.90880.D7.Full Text Link to Item
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Mathew, Joseph P., Hilary P. Grocott, Barbara Phillips-Bute, Mark Stafford-Smith, Daniel T. Laskowitz, Daniel Rossignol, James A. Blumenthal, Mark F. Newman, Mark F. Neurologic Outcome Research Group of the Duke Heart Center, and Mark F. Cardiothoracic Anesthesiology Research Endeavors Investigators of the Duke Heart Center. “Lower endotoxin immunity predicts increased cognitive dysfunction in elderly patients after cardiac surgery.” Stroke 34, no. 2 (February 2003): 508–13. https://doi.org/10.1161/01.str.0000053844.09493.58.Full Text Link to Item
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Podgoreanu, Mihai V., Robert G. Stout, Habib E. El-Moalem, and David G. Silverman. “Synchronous rhythmical vasomotion in the human cutaneous microvasculature during nonpulsatile cardiopulmonary bypass.” Anesthesiology 97, no. 5 (November 2002): 1110–17. https://doi.org/10.1097/00000542-200211000-00012.Full Text Link to Item
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Djaiani, George N., Brian J. McCreath, Lian K. Ti, Burkhard G. Mackensen, Mihai Podgoreanu, Barbara Phillips-Bute, and Joseph P. Mathew. “Mitral flow propagation velocity identifies patients with abnormal diastolic function during coronary artery bypass graft surgery.” Anesth Analg 95, no. 3 (September 2002): 524–30. https://doi.org/10.1097/00000539-200209000-00004.Full Text Link to Item
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Awad, A. A., W. Ouda, M. Podgoreanu, A. Ghobashy, and D. G. Silverman. “Different responses of forehead and finger laser Doppler flowmetry to vasoconstrictive stimuli.” Anesthesiology 93, no. 3A (September 1, 2000): U164–U164.Link to Item
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Podgoreanu, M. V., R. G. Stout, A. Ghobashy, and D. G. Silverman. “Progressive development of vasomotor activity during non-pulsatile perfusion.” Anesthesiology 93, no. 3A (September 1, 2000): U173–U173.Link to Item
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Podgoreanu, M., R. G. Stout, E. M. Ferneini, A. Ghobashy, and D. G. Silverman. “Delineation of peripheral vasomotor activity during extracorporeal circulation.” Anesthesiology 93, no. 3A (September 1, 2000): U139–U139.Link to Item
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Afifi, S., M. Podgoreanu, L. Davis, M. Sivarajan, S. Garwood, P. Barash, and S. Harris. “Is the routine use of intraoperative transesophageal echocardiography (TEE) justified?” Anesthesia and Analgesia 90, no. 4 (April 1, 2000): SCA82–SCA82.Link to Item
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Tantawy, H., D. G. Silverman, T. ElKadi, V. Kurup, A. Nazeer, E. M. Ferneini, A. Radwan, M. Podgoreanu, and R. G. Stout. “Different responses of time and spectral domain analyses to alterations in vagal activity induced by metronome breathing and phenylephrine infusion.” Anesthesia and Analgesia 90, no. 2 (February 1, 2000): U71–U71.Link to Item
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Afifi, S., M. Podgoreanu, and L. Grecu. “Arterial-venous Co-2 tension gradient (Pa-vCo(2)) reflects oxygen debt after cardiopulmonary bypass.” Critical Care Medicine 27, no. 12 (December 1, 1999): A77–A77.Link to Item
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Afifi, S., and M. Podgoreanu. “Carbon dioxide production (vCo(2)) predicts after heart surgery better than end tidal Co-2.” Critical Care Medicine 27, no. 12 (December 1, 1999): A77–A77.Link to Item
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Afifi, S., M. Podgoreanu, and L. Grecu. “Arterial-venous CO2 tension difference reflects oxygen debt after cardiopulmonary bypass.” Critical Care Medicine 27, no. 12 SUPPL. (January 1, 1999). https://doi.org/10.1097/00003246-199912001-00295.Full Text
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Afifi, S., M. Podgoreanu, and L. Grecu. “Arterial-venous CO2 tension gradient (Pa-vCO2) reflects oxygen debt after cardiopulmonary bypass.” Critical Care Medicine 27, no. 12 SUPPL. (January 1, 1999). https://doi.org/10.1097/00003246-199912001-00192.Full Text
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Afifi, S., and M. Podgoreanu. “Carbon dioxide production (VCO2) predicts after heart surgery better than end tidal CO2.” Critical Care Medicine 27, no. 12 SUPPL. (January 1, 1999). https://doi.org/10.1097/00003246-199912001-00191.Full Text
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Book Sections
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Podgoreanu, M. V. “Perioperative Genomics.” In Genomic and Precision Medicine: Cardiovascular Disease: Third Edition, 235–76, 2018. https://doi.org/10.1016/B978-0-12-801812-5.00009-3.Full Text
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Hashmi, N. K., and M. V. Podgoreanu. “Stress Response to Surgery in the Elderly.” In Principles of Geriatric Critical Care, 168–86, 2018. https://doi.org/10.1017/9781316676325.013.Full Text
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Friede, K., J. P. Mathew, and M. Podgoreanu. “Genomic Basis of Perioperative Medicine.” In Clinical Anesthesia: Ebook Without Multimedia. Lippincott Williams & Wilkins, 2013.
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Kiefer, T., and M. V. Podgoreanu. “Cardiac receptors.” In Core Topics in Cardiac Anesthesia, Second Edition, 39–47, 2012. https://doi.org/10.1017/CBO9780511979095.013.Full Text
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Body, S. C., M. V. Podgoreanu, and D. A. Schwinn. “Genomics of Perioperative and Procedural Medicine.” In Genomic and Personalized Medicine: V1-2, 794–805, 2008. https://doi.org/10.1016/B978-0-12-369420-1.00066-4.Full Text
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Other Articles
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Kertai, Miklos D., Yen-Wei Li, Yi-Ju Li, Svati H. Shah, William E. Kraus, Manuel L. Fontes, Mark Stafford-Smith, et al. “G protein-coupled receptor kinase 5 gene polymorphisms are associated with postoperative atrial fibrillation after coronary artery bypass grafting in patients receiving β-blockers.” Circ Cardiovasc Genet, October 2014. https://doi.org/10.1161/CIRCGENETICS.113.000451.Full Text Link to Item
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McDonagh, David L., Joseph P. Mathew, Willam D. White, Barbara Phillips-Bute, Daniel T. Laskowitz, Mihai V. Podgoreanu, Mark F. Newman, and Mark F. Neurologic Outcome Research Group. “Cognitive function after major noncardiac surgery, apolipoprotein E4 genotype, and biomarkers of brain injury.” Anesthesiology, April 2010. https://doi.org/10.1097/ALN.0b013e3181d31fd7.Full Text Link to Item
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Conference Papers
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Rosenkrans, D., W. Qi, M. Cooter, A. Cherry, S. McCartney, N. Hashmi, J. Schroder, C. Milano, M. Podgoreanu, and A. Nicoara. “EUROMACS-RHF Risk Score and 3D Echocardiography as Predictors of Right Heart Failure after Left Ventricular Assist Device Implantation.” In The Journal of Heart and Lung Transplantation : The Official Publication of the International Society for Heart Transplantation, 39:S403–4, 2020. https://doi.org/10.1016/j.healun.2020.01.149.Full Text
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Karhausen, Jörn A., Wenjing Qi, Alan M. Smeltz, Yi-Ju Li, Svati H. Shah, William E. Kraus, Joseph P. Mathew, Mihai V. Podgoreanu, Miklos D. Kertai, and Miklos D. Duke Perioperative Genetics Safety Outcomes (PEGASUS) Investigative Team. “Genome-Wide Association Study Links Receptor Tyrosine Kinase Inhibitor Sprouty 2 to Thrombocytopenia after Coronary Artery Bypass Surgery.” In Thromb Haemost, 118:1572–85, 2018. https://doi.org/10.1055/s-0038-1667199.Full Text Link to Item
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Quinones, Quintin J., Qing Ma, Michael P. Smith, Janet Staats, Cliburn Chan, Brian M. Barnes, and Mihai V. Podgoreanu. “Adaptations of Innate Immunity in Hibernation: Mechanisms for Protection Against Acute Organ Injury.” In Circulation, Vol. 132. LIPPINCOTT WILLIAMS & WILKINS, 2015.Link to Item
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Zhang, Zhiquan, Qing Ma, and Mihai V. Podgoreanu. “Annexin-A1 Bioactive Peptide Ameliorates Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI) in Rats by Upregulating the Sirtuin6/FoxO3 Pathway.” In Circulation, Vol. 132. LIPPINCOTT WILLIAMS & WILKINS, 2015.Link to Item
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Yamada, Miki, Amir Sheikh, Kevin Collins, James Frederiksen, George Quick, Andrew Lodge, and Mihai Podgoreanu. “Early Myocardial Gene Expression Profiling After Deep Hypothermic Circulatory Arrest Reveals Ontogenetic Adaptive Mechanisms Underlying Ischemia-Reperfusion Tolerance in the Swine.” In Circulation, Vol. 130. LIPPINCOTT WILLIAMS & WILKINS, 2014.Link to Item
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Zhang, Zhiquan, Qing Ma, and Mihai V. Podgoreanu. “Activation of Sirtuin 3 Protects the Heart From Ischemia-Reperfusion Injury by Increased Cellular Antioxidant Defenses.” In Circulation, Vol. 130. LIPPINCOTT WILLIAMS & WILKINS, 2014.Link to Item
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Quinones, Quintin J., Qing Ma, Zhiquan Zhang, Ricardo Henao, Erik Soderblom, Martin A. Moseley, Christopher Newgard, Kelly Drew, Brian M. Barnes, and Mihai V. Podgoreanu. “Proteomic Profiling Reveals Reduction in Electron Transport Chain Proteins in the Hearts of Hibernating Arctic Ground Squirrels Compared with Rats after Surgical Ischemia and Reperfusion: A Convergence of Mammalian Cardio-protective Strategies.” In Circulation, Vol. 130. LIPPINCOTT WILLIAMS & WILKINS, 2014.Link to Item
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Dulai, Gurpreet, Quintin Quinones, Mihai Podgoreanu, Brian Barnes, and Matthias Riess. “Preserved mitochondrial calcium retention capacity in summer-active Arctic ground squirrels undergoing normothermic myocardial ischemia/reperfusion injury.” In Faseb Journal, Vol. 28. FEDERATION AMER SOC EXP BIOL, 2014.Link to Item
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Dulai, Gurpreet K., Mihai V. Podgoreanu, Brian M. Barnes, Quintin J. Quinones, and Matthias L. Riess. “Resistance Against Normothermic Myocardial Ischemia/Reperfusion Injury in Summer-Active Arctic Ground Squirrels Is Associated With Preserved Mitochondrial Function.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.Link to Item
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Ouinones, Quintin J., Qing Ma, Ricardo Henao, Joseph Lucas, Matthias L. Riess, James Bain, Christopher B. Newgard, Brian M. Barnes, and Mihai V. Podgoreanu. “Proteomnic and Metabolomic Profiling After Isehemia-Reperfusion Injury Reveals Bottlenecks That Underlie Cardioprotection in Hibernating Mammals.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.Link to Item
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Zhang, Zhiquan, Qing Ma, Quintin Quinones, and Mihai V. Podgoreanu. “Annexin-A1 Biomimetic Peptide Attenuates Myocardial Ischemia-Reperfusion Injury via Increased Sirtuin-3.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.Link to Item
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Zhang, Zhiquan, Qing Ma, and Mihai V. Podgoreanu. “Annexin-A1 Bioactive Peptide Provides Neuroprotection by Attenuating Microglial Activation Following Cardiac Surgery in Rats.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.Link to Item
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Zhang, Zhiquan, Qing Ma, Burkhard G. Mackensen, and Mihai V. Podgoreanu. “Annexin-A1 Mimetic Peptide and PPAR-alpha Agonist Attenuate Hyperglycemic Exacerbation of Myocardial Ischemia/Reperfusion Injury Following Cardioplegic Arrest in the Rat.” In Circulation, 120:S731–S731. LIPPINCOTT WILLIAMS & WILKINS, 2009.Link to Item
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Podgoreanu, M. V., W. D. White, J. P. Mathew, M. Stafford-Smith, I. J. Welsby, M. F. Newman, and D. A. Schwinn. “Inflammatory gene polymorphisms and risk of postoperative myocardial infarction following cardiac surgery.” In Circulation, 112:U432–U432. LIPPINCOTT WILLIAMS & WILKINS, 2005.Link to Item
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Podgoreanu, M. V., W. D. White, J. P. Mathew, M. Stafford-Smith, I. J. Welsby, M. F. Newman, and D. A. Schwinn. “Inflammatory gene polymorphisms and risk of postoperative myocardial infarction following cardiac surgery.” In Circulation, 112:U37–U37. LIPPINCOTT WILLIAMS & WILKINS, 2005.Link to Item
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De Meyts, D., M. Swaminathan, M. Podgoreanu, J. Booth, R. Morris, F. Clements, H. Grocott, M. Newman, and J. Mathew. “Deterioration of regional wall motion immediately following CABG surgery is associated with long-term major adverse cardiac events.” In Anesthesia and Analgesia, 98:35–35. LIPPINCOTT WILLIAMS & WILKINS, 2004.Link to Item
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Podgoreanu, M., W. White, J. Booth, M. Swaminathan, J. Mathew, M. Newman, and D. Schwinn. “Functional polymorphisms in the beta2 adrenergic receptor gene are associated with adverse outcomes following cardiac surgery.” In Anesthesia and Analgesia, 98:32–32. LIPPINCOTT WILLIAMS & WILKINS, 2004.Link to Item
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Swaminathan, M., M. Podgoreanu, Y. Sato, H. Grocott, M. Stafford-Smith, and G. Michelotti. “Cardiopulmonary bypass induces differential gene expression in the kidney.” In Anesthesia and Analgesia, 98:77–77. LIPPINCOTT WILLIAMS & WILKINS, 2004.Link to Item
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Welsby, I. J., M. Podgoreanu, J. Mathew, B. Phillips-Bute, M. F. Newman, D. A. Schwinn, and M. Stafford-Smith. “The genetics of bleeding after cardiac surgery.” In American Journal of Human Genetics, 73:517–517. UNIV CHICAGO PRESS, 2003.Link to Item
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Podgoreanu, M. V., J. V. Booth, W. D. White, B. Phillips-Bute, G. A. Michelotti, J. P. Mathew, M. F. Newman, and D. A. Schwinn. “Beta adrenergic receptor polymorphisms and risk of adverse events following cardiac surgery.” In Circulation, 108:434–434. LIPPINCOTT WILLIAMS & WILKINS, 2003.Link to Item
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Podgoreanu, M. V., G. A. Michelotti, H. Grocott, and D. Schwinn. “Cardiopulmonary bypass induces changes in myocardial gone expression even in the absence of ischemia-reperfusion.” In Circulation, 106:E90–E90. LIPPINCOTT WILLIAMS & WILKINS, 2002.Link to Item
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