Overview
Basic-Translational:
1. Systems biology approaches to modeling perioperative cardiovascular injury and adaptation.
2. Mechanisms of perioperative myocardial injury; functional genomics applied to perioperative myocardial injury.
3. Metabolic consequences of perioperative myocardial ischemia-reperfusion injury.
4. Animal models and comparative genomic approaches to study perioperative myocardial ischemia-reperfusion injury.
5. Functional genomics of vein graft disease.
6. Animal models of vein graft disease.
7. Genetic association studies in perioperative medicine.
8. Clinico-genomic risk prediction models for perioperative and long-term adverse cardiovascular outcomes following cardiac surgery.
Clinical:
9. Intraoperative quantification of tissue perfusion by contrast echocardiography.
10. Use of myocardial tissue deformation indices to characterize perioperative ventricular dysfunction/stunning
11. 3-D echocardiographic evaluation of the right ventricle
1. Systems biology approaches to modeling perioperative cardiovascular injury and adaptation.
2. Mechanisms of perioperative myocardial injury; functional genomics applied to perioperative myocardial injury.
3. Metabolic consequences of perioperative myocardial ischemia-reperfusion injury.
4. Animal models and comparative genomic approaches to study perioperative myocardial ischemia-reperfusion injury.
5. Functional genomics of vein graft disease.
6. Animal models of vein graft disease.
7. Genetic association studies in perioperative medicine.
8. Clinico-genomic risk prediction models for perioperative and long-term adverse cardiovascular outcomes following cardiac surgery.
Clinical:
9. Intraoperative quantification of tissue perfusion by contrast echocardiography.
10. Use of myocardial tissue deformation indices to characterize perioperative ventricular dysfunction/stunning
11. 3-D echocardiographic evaluation of the right ventricle
Current Duke Appointments & Affiliations
Associate Professor of Anesthesiology
·
2011 - Present
Anesthesiology, Cardiothoracic,
Anesthesiology
Chief, Division of Cardiac Anesthesiology
·
2013 - Present
Anesthesiology, Cardiothoracic,
Anesthesiology
Recent Scholarly Works
A dedicated modular system for open-chest stabilization in thoracic transplantation.
Journal article J Heart Lung Transplant · May 25, 2026 Delayed chest closure is frequently required following heart and lung transplantation due to graft edema, bleeding, size mismatch, or hemodynamic instability, yet current open-chest management strategies rely largely on improvised spacers with recognized m ... Full text Link to item CiteConsiderations in interpreting pulmonary artery pulsatility index and right ventricle-pulmonary arterial coupling in left ventricular assist device candidates.
Journal article J Heart Lung Transplant · May 2026 Full text Link to item CiteImpact of left ventricular assist device implantation on right ventricular-pulmonary arterial coupling assessed by high-fidelity hemodynamics.
Journal article J Heart Lung Transplant · April 2026 BACKGROUND: Postoperative right ventricular (RV) adaptation to left ventricular assist device (LVAD) implantation remains poorly characterized. RV-pulmonary artery (PA) coupling, defined as the ratio of end-systolic to arterial elastance (Ees/Ea), provides ... Full text Link to item CiteRecent Grants
Integrated Training in Anesthesiology Research
Inst. Training Prgm or CMEMentor · Awarded by National Institute of General Medical Sciences · 1996 - 2031Minimizing ICU Neurological Dysfunction with Dexmedetomidine-induced Sleep (MINDDS II)
ResearchPrincipal Investigator · Awarded by Massachusetts General Hospital · 2024 - 2029Patient-Focused Collaborative Hospital Repository Uniting Standards (CHoRUS) for Equitable AI
ResearchPrincipal Investigator · Awarded by Massachusetts General Hospital · 2022 - 2026View All Grants
Education
Carol Davila University of Medicine and Pharmacy (Romania) ·
1993
M.D.