Skip to main content

Michael Arthur Hauser

Professor in Medicine
Medicine, Medical Genetics
Duke Box 104775, Durham, NC 27710
2016 Genome Science Research Bldg I, Durham, NC 27710

Overview


Dr. Hauser has a strong interest in ocular genetics. Genomic studies at the Center for Human Genetics have identified multiple linkage peaks and susceptibility genes in primary open angle glaucoma (POAG) and age related macular degeneration (AMD). Dr. Hauser has recently accepted a 20% appointment at the Singapore Eye Research INstitute and the Duke/National University of Singapore.  In collaboration with multiple collaborators in Singapore, and Dr. Rand Allingham at the Duke Eye Center, Dr. Hauser is currently conducting a genome wide association study for glaucoma in individuals of African ancestry. These investigations include large datasets collected in Ghana, Nigeria, and South Africa.  
 
Dr. Hauser is also involved in collaborative investigations into the genetics of post-tramatic stress disorder in US veterans from Iraq and Afghanistan.   Major collaborators include Dr. Allison Ashley Koch, Dr. Jean Beckham, Dr. Christine Marx and the MIRECC Collaborative group at the Durham Veteran's Administration.  We have published a genome wide association study, as well as numerous investigations into candidate genes.  Epigenomic DNA methylation analysis and gene expression analysis of 3500 individuals is currently ongoing.

Current Appointments & Affiliations


Professor in Medicine · 2021 - Present Medicine, Medical Genetics, Medicine
Associate Research Professor in Molecular Genetics and Microbiology · 2008 - Present Molecular Genetics and Microbiology, Basic Science Departments
Member of Duke Molecular Physiology Institute · 2013 - Present Duke Molecular Physiology Institute, Institutes and Centers

In the News


Published January 13, 2014
Global Research, Domestic Benefits

View All News

Recent Publications


Performance of Polygenic Risk Scores for Primary Open-Angle Glaucoma in Populations of African Descent.

Journal Article JAMA Ophthalmol · January 1, 2025 IMPORTANCE: Primary open-angle glaucoma (POAG) polygenic risk scores (PRSs) continue to be evaluated in primarily European-ancestry populations despite higher prevalence and worse outcomes in African-ancestry populations. OBJECTIVE: To evaluate how establi ... Full text Link to item Cite

Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts.

Journal Article Genome Med · December 18, 2024 BACKGROUND: The occurrence of post-traumatic stress disorder (PTSD) following a traumatic event is associated with biological differences that can represent the susceptibility to PTSD, the impact of trauma, or the sequelae of PTSD itself. These effects inc ... Full text Link to item Cite

Genome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries.

Journal Article Nat Genet · December 2024 To effectively reduce vision loss due to age-related macular generation (AMD) on a global scale, knowledge of its genetic architecture in diverse populations is necessary. A critical element, AMD risk profiles in African and Hispanic/Latino ancestries, rem ... Full text Link to item Cite
View All Publications

Recent Grants


Prioritizing diversity in polygenic risk prediction of primary open-angle glaucoma

ResearchPrincipal Investigator · Awarded by East Carolina University · 2024 - 2027

Single nuclear RNAseq to characterize glaucoma risk genes

ResearchPrincipal Investigator · Awarded by BrightFocus Foundation · 2021 - 2026

Molecular Mechanisms of Exfoliation Glaucoma

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2025

View All Grants

Education, Training & Certifications


Johns Hopkins University · 1990 Ph.D.