Overview
Dr. Hauser has a strong interest in ocular genetics. Genomic studies at the Center for Human Genetics have identified multiple linkage peaks and susceptibility genes in primary open angle glaucoma (POAG) and age related macular degeneration (AMD). Dr. Hauser has recently accepted a 20% appointment at the Singapore Eye Research INstitute and the Duke/National University of Singapore. In collaboration with multiple collaborators in Singapore, and Dr. Rand Allingham at the Duke Eye Center, Dr. Hauser is currently conducting a genome wide association study for glaucoma in individuals of African ancestry. These investigations include large datasets collected in Ghana, Nigeria, and South Africa.
Dr. Hauser is also involved in collaborative investigations into the genetics of post-tramatic stress disorder in US veterans from Iraq and Afghanistan. Major collaborators include Dr. Allison Ashley Koch, Dr. Jean Beckham, Dr. Christine Marx and the MIRECC Collaborative group at the Durham Veteran's Administration. We have published a genome wide association study, as well as numerous investigations into candidate genes. Epigenomic DNA methylation analysis and gene expression analysis of 3500 individuals is currently ongoing.
Dr. Hauser is also involved in collaborative investigations into the genetics of post-tramatic stress disorder in US veterans from Iraq and Afghanistan. Major collaborators include Dr. Allison Ashley Koch, Dr. Jean Beckham, Dr. Christine Marx and the MIRECC Collaborative group at the Durham Veteran's Administration. We have published a genome wide association study, as well as numerous investigations into candidate genes. Epigenomic DNA methylation analysis and gene expression analysis of 3500 individuals is currently ongoing.
Current Appointments & Affiliations
Professor in Medicine
·
2021 - Present
Medicine, Medical Genetics,
Medicine
Associate Research Professor in Molecular Genetics and Microbiology
·
2008 - Present
Molecular Genetics and Microbiology,
Basic Science Departments
Member of Duke Molecular Physiology Institute
·
2013 - Present
Duke Molecular Physiology Institute,
Institutes and Centers
Recent Publications
Performance of Polygenic Risk Scores for Primary Open-Angle Glaucoma in Populations of African Descent.
Journal Article JAMA Ophthalmol · January 1, 2025 IMPORTANCE: Primary open-angle glaucoma (POAG) polygenic risk scores (PRSs) continue to be evaluated in primarily European-ancestry populations despite higher prevalence and worse outcomes in African-ancestry populations. OBJECTIVE: To evaluate how establi ... Full text Link to item CiteEpigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts.
Journal Article Genome Med · December 18, 2024 BACKGROUND: The occurrence of post-traumatic stress disorder (PTSD) following a traumatic event is associated with biological differences that can represent the susceptibility to PTSD, the impact of trauma, or the sequelae of PTSD itself. These effects inc ... Full text Link to item CiteGenome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries.
Journal Article Nat Genet · December 2024 To effectively reduce vision loss due to age-related macular generation (AMD) on a global scale, knowledge of its genetic architecture in diverse populations is necessary. A critical element, AMD risk profiles in African and Hispanic/Latino ancestries, rem ... Full text Link to item CiteRecent Grants
Prioritizing diversity in polygenic risk prediction of primary open-angle glaucoma
ResearchPrincipal Investigator · Awarded by East Carolina University · 2024 - 2027Single nuclear RNAseq to characterize glaucoma risk genes
ResearchPrincipal Investigator · Awarded by BrightFocus Foundation · 2021 - 2026Molecular Mechanisms of Exfoliation Glaucoma
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2025View All Grants
Education, Training & Certifications
Johns Hopkins University ·
1990
Ph.D.