Misha Angrist
Associate Professor of the Practice in the Social Science Research Institute
Misha Angrist is Associate Professor of the Practice at SSRI, a Senior Fellow in Science & Society, and Visiting Associate Professor of the Practice in the Sanford School of Public Policy as part of the DeWitt Wallace Center for Media & Democracy. He is the Associate Director of the Genome Sciences & Policy Certificate. He serves as the lead of the Public Impact & Engagement track for the MA in Bioethics & Science Policy and as a faculty mentor; he teaches in the MA program as well science writing for undergraduates. In his work, he explores the intersection of biology and society, especially as it relates to the governance of human participation in research and medicine. As the fourth participant in the Personal Genome Project, he was among the first to have his entire genome sequenced and made public. He chronicled this experience in his book, Here is a Human Being: At the Dawn of Personal Genomics. Angrist has an MFA from the Bennington Writing Seminars, an MS in genetic counseling from the University of Cincinnati, and a PhD in genetics from Case Western Reserve University.
Current Appointments & Affiliations
- Associate Professor of the Practice in the Social Science Research Institute, Social Science Research Institute, University Institutes and Centers 2014
- Senior Fellow in the Duke Initiative for Science & Society, Duke Science & Society, Initiatives 2014
Contact Information
- Box 90222, North Building Room 237, Durham, NC 27708-0222
- Box 90222, North Building Room 237, Durham, NC 27708-0222
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(919) 684-2872
- Background
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Education, Training, & Certifications
- M.F.A., Bennington College 2001
- Ph.D., Case Western Reserve University 1996
- M.S., University of Cincinnati 1990
- B.A., Indiana University at Bloomington 1985
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Duke Appointment History
- Visiting Associate Professor of the Practice in the Sanford School of Public Policy, Sanford School of Public Policy, Duke University 2015 - 2016
- Assistant Professor of the Practice in the Institute for Genome Sciences & Policy, University Institutes and Centers, Institutes and Provost's Academic Units 2012 - 2014
- Assistant Professor of the Practice in the Institute for Genome Sciences & Policy, Institutes and Centers, School of Medicine 2008 - 2012
- Assistant Professor of the Practice in the Institute for Genome Sciences & Policy, University Institutes and Centers, Institutes and Provost's Academic Units 2010 - 2012
- Recognition
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In the News
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Awards & Honors
- Publications & Artistic Works
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Selected Publications
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Journal Articles
- Angrist, M. "Personal genomics: Where are we now?." Applied & translational genomics 8 (March 2016): 1-3. Full Text
- Angrist, M. "Start me up: ways to encourage sharing of genomic information with research participants." Nature reviews. Genetics 16, no. 8 (August 2015): 435-436. Full Text
- Angrist, M, and Jamal, L. "Living laboratory: whole-genome sequencing as a learning healthcare enterprise." Clinical genetics 87, no. 4 (April 2015): 311-318. (Review) Full Text
- Angrist, M, and Jamal, L. "Living laboratory: Whole-genome sequencing as a learning healthcare enterprise." Clinical Genetics 87, no. 4 (January 1, 2015): 311-318. (Review) Full Text
- Angrist, M, and Cook-Deegan, R. "Distributing the future: The weak justifications for keeping human genomic databases secret and the challenges and opportunities in reverse engineering them." Applied & translational genomics 3, no. 4 (December 2014): 124-127. Full Text
- Angrist, M. "The audacity of interpretation: Protecting patients or piling on?." Applied & translational genomics 3, no. 3 (September 2014): 68-69. Full Text
- Lu, Y-F, Goldstein, DB, Angrist, M, and Cavalleri, G. "Personalized medicine and human genetic diversity." Cold Spring Harbor perspectives in medicine 4, no. 9 (September 2014): a008581-. (Review) Full Text
- Davis, EE, Savage, JH, Willer, JR, Jiang, Y-H, Angrist, M, Androutsopoulos, A, and Katsanis, N. "Whole exome sequencing and functional studies identify an intronic mutation in TRAPPC2 that causes SEDT." Clin Genet 85, no. 4 (April 2014): 359-364. Full Text Link to Item
- Davis, EE, Savage, JH, Willer, JR, Jiang, YH, Angrist, M, Androutsopoulos, A, and Katsanis, N. "Whole exome sequencing and functional studies identify an intronic mutation in TRAPPC2 that causes SEDT." Clinical Genetics 85, no. 4 (April 1, 2014): 359-364. Full Text
- Angrist, M, and Cook-Deegan, R. "Distributing the future: The weak justifications for keeping human genomic databases secret and the challenges and opportunities in reverse engineering them." Applied and Translational Genomics 3, no. 4 (2014): 124-127. Full Text
- Angrist, M. "Open window: when easily identifiable genomes and traits are in the public domain." PloS one 9, no. 3 (January 2014): e92060-. Full Text
- Angrist, M. "Genetic privacy needs a more nuanced approach." Nature 494, no. 7435 (2013): 7--. Full Text
- Ball, MP, Thakuria, JV, Zaranek, AW, Clegg, T, Rosenbaum, AM, Wu, X, Angrist, M, Bhak, J, Bobe, J, Callow, MJ, Cano, C, Chou, MF, Chung, WK, Douglas, SM, Estep, PW, Gore, A, Hulick, P, Labarga, A, Lee, J-H, Lunshof, JE, Kim, BC, Kim, J-I, Li, Z, Murray, MF, Nilsen, GB, Peters, BA, Raman, AM, Rienhoff, HY, Robasky, K, Wheeler, MT, Vandewege, W, Vorhaus, DB, Yang, JL, Yang, L, Aach, J, Ashley, EA, Drmanac, R, Kim, S-J, Li, JB, Peshkin, L, Seidman, CE, Seo, J-S, Zhang, K, Rehm, HL, and Church, GM. "A public resource facilitating clinical use of genomes." Proceedings of the National Academy of Sciences of the United States of America 109, no. 30 (2012): 11920-11927. Full Text
- Katsanis, N, Cotten, M, and Angrist, M. "Exome and genome sequencing of neonates with neurodevelopmental disorders." Future Neurology 7, no. 6 (2012): 655-658. Full Text
- Angrist, M. "You never call, you never write: Why return of 'omic' results to research participants is both a good idea and a moral imperative." Personalized Medicine 8, no. 6 (2011): 651-657. Full Text
- Lunshof, JE, Bobe, J, Aach, J, Angrist, M, Thakuria, JV, Vorhaus, DB, Hoehe, MR, and Church, GM. "Personal genomes in progress: From the human genome project to the Personal Genome Project." Dialogues in Clinical Neuroscience 12, no. 1 (December 2, 2010): 44-57.
- Carbone, J, Gold, ER, Sampat, B, Chandrasekharan, S, Knowles, L, Angrist, M, and Cook-Deegan, R. "DNA patents and diagnostics: not a pretty picture." Nat Biotechnol 28, no. 8 (August 2010): 784-791. Full Text Link to Item
- Angrist, M. "Orchid agonistes." NATURE 465, no. 7297 (May 27, 2010): 518-518. Full Text Link to Item
- Angrist, M, Chandrasekharan, S, Heaney, C, and Cook-Deegan, R. "Impact of gene patents and licensing practices on access to genetic testing for long QT syndrome." Genet Med 12, no. 4 Suppl (April 2010): S111-S154. Full Text Link to Item
- Angrist, M. "Urge overkill: Protecting deidentified human subjects at what price?." American Journal of Bioethics 10, no. 9 (2010): 17-18. Full Text
- Angrist, M. "Only connect: Personal genomics and the future of american medicine." Molecular Diagnosis and Therapy 14, no. 2 (2010): 67-72. Full Text
- Lunshof, JE, Bobe, J, Aach, J, Angrist, M, Thakuria, JV, Vorhaus, DB, Hoehe, MR, and Church, GM. "Personal genomes in progress: From the human genome project to the Personal Genome Project." Dialogues in Clinical Neuroscience 12, no. 1 (2010): 44-57.
- Lunshof, JE, Bobe, J, Aach, J, Angrist, M, Thakuria, JV, Vorhaus, DB, Hoehe, MR, and Church, GM. "Personal genomes in progress: from the human genome project to the personal genome project." Dialogues in clinical neuroscience 12, no. 1 (2010): 47-60.
- Cook-Deegan, R, Chandrasekharan, S, and Angrist, M. "The dangers of diagnostic monopolies." Nature 458, no. 7237 (March 26, 2009): 405-406. Full Text Link to Item
- Angrist, M. "We are the genes we've been waiting for: Rational responses to the gathering storm of personal genomics." American Journal of Bioethics 9, no. 6-7 (2009): 30-31. Full Text
- Angrist, M. "Eyes wide open: The personal genome project, citizen science and veracity in informed consent." Personalized Medicine 6, no. 6 (2009): 691-699. Full Text
- Angrist, M. "Personal genomics: Access denied? : Consumers have a right to their genomes." Technology Review 111, no. 5 (2008).
- Ginsburg, GS, Angrist, M, and Cook-Deegan, R. "Public health. Genomics and medicine at a crossroads in Chernobyl." Science 314, no. 5796 (October 6, 2006): 62-63. Full Text Link to Item
- Angrist, M, and Cook-Deegan, RM. "Who owns the genome?." New Atlantis 11 (2006): 87-96. Link to Item
- Angrist, M. "Paper boy." Literary Review 49, no. 4 (2006): 130--.
- Ginsburg, GS, and Angrist, M. "The future may be closer than you think: A response from the personalized medicine coalition to the Royal Society's report on personalized medicine." Personalized Medicine 3, no. 2 (2006): 119-123. Full Text
- Willard, HF, Angrist, M, and Ginsburg, GS. "Genomic medicine: genetic variation and its impact on the future of health care." Philos Trans R Soc Lond B Biol Sci 360, no. 1460 (August 29, 2005): 1543-1550. (Review) Full Text Link to Item
- Angrist, M. "Breast cancer: Integrating the patient with her genome." Trends in Biotechnology 23, no. 1 (2005): 3-5. Full Text
- Blagoev, B, Nielsen, MM, Angrist, M, Chakravarti, A, and Pandey, A. "Cloning of rat thymic stromal lymphopoietin receptor (TSLPR) and characterization of genomic structure of murine Tslpr gene." Gene 284, no. 1-2 (2002): 161-168. Full Text
- Gabriel, SB, Salomon, R, Pelet, A, Angrist, M, Amiel, J, Fornage, M, Attié-Bitach, T, Olson, JM, Hofstra, R, Buys, C, Steffann, J, Munnich, A, Lyonnet, S, and Chakravarti, A. "Segregation at three loci explains familial and population risk in Hirschsprung disease." Nature Genetics 31, no. 1 (2002): 89-93. Full Text
- Bolk, S, Pelet, A, Hofstra, RMW, Angrist, M, Salomon, R, Croaker, D, Buys, CHCM, Lyonnet, S, and Chakravarti, A. "A human model for multigenic inheritance: Phenotypic expression in Hirschsprung disease requires both the RET gene and a new 9q31 locus." Proceedings of the National Academy of Sciences of the United States of America 97, no. 1 (2000): 268-273. Full Text
- Southard-Smith, EM, Angrist, M, Ellison, JS, Agarwala, R, Baxevanis, AD, Chakravarti, A, and Pavan, WJ. "The Sox10(Dom) mouse: Modeling the genetic variation of Waardenburg-Shah (WS4) syndrome." Genome Research 9, no. 3 (1999): 215-225.
- Angrist, M, Bolk, S, Bentley, K, Nallasamy, S, Halushka, MK, and Chakravarti, A. "Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its role in Hirschsprung disease." Oncogene 17, no. 23 (1998): 3065-3070.
- Angrist, M, Jing, S, Bolk, S, Bentley, K, Nallasamy, S, Halushka, M, Fox, GM, and Chakravarti, A. "Human GFRA1: Cloning, mapping, genomic structure, and evaluation as a candidate gene for hirschsprung disease susceptibility." Genomics 48, no. 3 (1998): 354-362. Full Text
- Angrist, M. "Less is more: Compact genomes pay dividends." Genome Research 8, no. 7 (1998): 683-685.
- Chadwick, BP, Helbling, LA, Angrist, M, Chakravarti, A, Gusella, JF, and Slaugenhaupt, SA. "Assignment of persephin (PSPN), a human neurotrophic factor, to chromosome 19p13.3 by radiation hybrid mapping and somatic cell hybrid PCR." Cytogenetics and Cell Genetics 83, no. 3-4 (1998): 236-237.
- Angrist, M. "Does phaster mean better?." Clinical chemistry 43, no. 3 (1997): 424-426.
- Angrist, M, Bolk, S, Halushka, M, Lapchak, PA, and Chakravarti, A. "Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient." Nature genetics 14, no. 3 (1996): 341-344.
- Bolk, S, Angrist, M, Schwartz, S, Silvestri, JM, Weese-Mayer, DE, and Chakravarti, A. "Congenital central hypoventilation syndrome: Mutation analysis of the receptor tyrosine kinase ret." American Journal of Medical Genetics - Seminars in Medical Genetics 63, no. 4 (1996): 603-609.
- Bolk, S, Angrist, M, Xie, J, Yanagisawa, M, Silvestri, JM, Weese-Mayer, DE, and Chakravarti, A. "Endothelin-3 frameshift mutation in congenital central hypoventilation syndrome." Nature Genetics 13, no. 4 (1996): 395-396. Full Text
- Hofstra, RMW, Osinga, J, Tan-Sindhunata, G, Wu, Y, Kamsteeg, E-J, Stulp, RP, Ravenswaaij-Arts, CV, Majoor-Krakauer, D, Angrist, M, Chakravarti, A, Meijers, C, and Buys, CHCM. "A homozygous mutation in the endothelin-3 gene associated with a combined Waardenburg type 2 and Hirschsprung phenotype (Shah-Waardenburg syndrome)." Nature Genetics 12, no. 4 (1996): 445-447. Full Text
- Angrist, M, Bolk, S, Thiel, B, Puffenberger, EG, Hofstra, RM, Buys, CHCM, Cass, DT, and Chakravarti, A. "Mutation analysis of the RET receptor tyrosine kinase in Hirschsprung disease." Human Molecular Genetics 4, no. 5 (1995): 821-830.
- Angrist, M, Wells, DE, Chakravarti, A, and Pandey, A. "Chromosomal localization of the mouse Src-like adapter protein (Slap) gene and its putative human homolog SLA." Genomics 30, no. 3 (1995): 623-625. Full Text
- Hentati, A, Pericak-Vance, MA, Lennon, F, Wasserman, B, Hentati, F, Juneja, T, Angrist, MH, Hung, WY, Boustany, RM, and Bohlega, S. "Linkage of a locus for autosomal dominant familial spastic paraplegia to chromosome 2p markers." Hum Mol Genet 3, no. 10 (October 1994): 1867-1871. Link to Item
- Puffenberger, EG, Kauffman, ER, Bolk, S, Matise, TC, Washington, SS, Angrist, M, Weissenbach, J, Garver, KL, Mascari, M, Ladda, R, Slaugenhaupt, SA, and Chakravarti, A. "Identity-by-descent and association mapping of a recessive gene for Hirschsprung disease on human chromosome 13q22." Human Molecular Genetics 3, no. 8 (1994): 1217-1225.
- Angrist, M, Kauffman, E, Slaugenhaupt, SA, Matise, TC, Puffenberger, EG, Washington, SS, Lipson, A, Cass, DT, Reyna, T, Weeks, DE, Sieber, W, and Chakravarti, A. "A gene for Hirschsprung disease (megacolon) in the pericentromeric region of human chromosome 10." Nature Genetics 4, no. 4 (1993): 351-356. Full Text
- Dalrymple, NJ, and Angrist, MH. "Autism resources at the higher education level in Indiana." Journal of Autism and Developmental Disorders 19, no. 1 (1989): 173-175. Full Text
- Dalrymple, NJ, and Angrist, MH. "Toilet training a sixteen year old with autism in a natural setting." British Journal of Mental Subnormality 34 II, no. 67 (1988): 117-130.
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- Teaching & Mentoring
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Recent Courses
- AAAS 196FS: Patient and Research Participant Activism and Advocacy 2018
- BIOETHIC 510S: Science and the Media: Narrative Writing about Science, Health and Policy 2018
- BIOETHIC 605S: Contemporary Issues in Bioethics and Science Policy 2018
- CULANTH 196FS: Patient and Research Participant Activism and Advocacy 2018
- GLHLTH 196FS: Patient and Research Participant Activism and Advocacy 2018
- PJMS 510S: Science and the Media: Narrative Writing about Science, Health and Policy 2018
- PSY 196FS: Patient and Research Participant Activism and Advocacy 2018
- PUBPOL 196FS: Patient and Research Participant Activism and Advocacy 2018
- PUBPOL 510S: Science and the Media: Narrative Writing about Science, Health and Policy 2018
- SCISOC 196FS: Patient and Research Participant Activism and Advocacy 2018
- SCISOC 256: Science and Society 2018
- SCISOC 293: Research Independent Study in Science & Society 2018
- SCISOC 498S: Science & Society Capstone 2018
- SOCIOL 196FS: Patient and Research Participant Activism and Advocacy 2018
- BIOETHIC 602S: Law, Research and Bioethics 2016
- BIOETHIC 700: Research Independent Study in Bioethics and Science Policy 2016
- GENOME 293-1: Research Independent Study in Genome Policy 2016
- GENOME 293: Research Independent Study in Genome Sciences 2016
- GENOME 498S: Genome Sciences and Policy Capstone 2016
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Advising & Mentoring
- Misha Angrist has lectured in Duke undergraduate and graduate courses since 2006 and taught courses in genome sciences and policy, science writing, patient advocacy, and human genetics as a Duke faculty member since 2008. He has served on many undergraduate thesis committees and overseen numerous independent study students. This work involves regular meetings and provision of feedback on and oversight of multiple revisions. Currently he is Associate Director of the Genome Sciences & Policy Certificate program and a core faculty member in the Master of Arts in Bioethics & Science Policy program. In the latter role he serves as a faculty advisor to current MA students and serves on their exam committees. He has also served as a thesis advisor to students in Public Policy and International Comparative Studies.
- Scholarly, Clinical, & Service Activities
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Outreach & Engaged Scholarship
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Service to the Profession
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Service to Duke
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