Scholars@Duke
Eugene William Moretti

Eugene William Moretti

Professor of Anesthesiology
Anesthesiology, General, Vascular, High Risk Transplant & Critical Care
moret002@mc.duke.edu
Box 3094 Med Ctr, Durham, NC
2301 Erwin Road, 5673 HAFS Building, Durham, NC 27710

Overview

Research efforts are focused primarily in the area of functional genomics. Work has centered on investigating genetic polymorphisms in the surgical intensive care population that would predispose one to the development of the sepsis syndrome. As an extension of this work, there is ongoing investigation working to identify genetically susceptible populations at risk for developing various types of perioperative organ dysfunction. Parallel studies involve identification of a panel of biomarkers that would enable early diagnosis and intervention for those patients, both surgical and non-surgical that develop the sepsis syndrome. There is also active investigation in the human pharmacology laboratory in the department of anesthesiology involving the phase 1 testing of novel pharmaceutical agents in healthy volunteers.

Current Appointments & Affiliations

Professor in the School of Nursing · 2014 - Present School of Nursing

Recent Publications

Apolipoprotein E Mimetic Peptide CN-105 and Postoperative Delirium in Older Patients: The Phase 2 MARBLE Randomized Clinical Trial.

Journal Article JAMA Netw Open · April 1, 2026 IMPORTANCE: The apolipoprotein E (APOE) gene ε4 allele leads to increased Alzheimer disease risk and neuroinflammation and is also believed to play a role in postoperative delirium. However, the safety and feasibility of modulating apoE protein signaling t ... Full text Link to item Cite

The Role of Sleep Apnea in Postoperative Neurocognitive Disorders Among Older Noncardiac Surgery Patients: A Prospective Cohort Study.

Journal Article Anesth Analg · January 1, 2025 BACKGROUND: Obstructive sleep apnea is associated with increased dementia risk, yet its role in postoperative neurocognitive disorders is unclear. Here, we studied whether the severity of untreated obstructive sleep apnea is associated with the severity of ... Full text Link to item Cite
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Recent Grants

Right Place, Right Time: Information Design to Support Decisions in Acute Care

ResearchCo Investigator · Awarded by Saint Alphonsus Regional Medical Center · 2015 - 2018

Toward intelligent display of health data: A qualitative study of use patterns

ResearchCo Investigator · Awarded by National Institutes of Health · 2011 - 2015

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Education

Duke University, School of Medicine · 2004 M.H.S.
Temple University · 1993 M.D.