Eugene William Moretti | Scholars@Duke

Eugene William Moretti
Professor of Anesthesiology

Research efforts are focused primarily in the area of functional genomics. Work has centered on investigating genetic polymorphisms in the surgical intensive care population that would predispose one to the development of the sepsis syndrome. As an extension of this work, there is ongoing investigation working to identify genetically susceptible populations at risk for developing various types of perioperative organ dysfunction. Parallel studies involve identification of a panel of biomarkers that would enable early diagnosis and intervention for those patients, both surgical and non-surgical that develop the sepsis syndrome. There is also active investigation in the human pharmacology laboratory in the department of anesthesiology involving the phase 1 testing of novel pharmaceutical agents in healthy volunteers.

Current Appointments & Affiliations

Professor of Anesthesiology, Anesthesiology, General, Vascular, High Risk Transplant & Critical Care, Anesthesiology 2021
Professor in the School of Nursing, School of Nursing, Duke University 2014

Contact Information

2301 Erwin Road, 5673 Hafs Building, Durham, NC 27710
Box 3094 Med Ctr, Durham, NC 27710
moret002@mc.duke.edu (919) 668-3400

Background
Education, Training, & Certifications
- M.H.S., Duke University School of Medicine 2004
- Fellowship, Critical Care Medicine, Duke University 1997 - 1998
- Residency, Anesthesiology, Duke University 1994 - 1997
- M.D., Temple University 1993
Previous Appointments & Affiliations
- Professor of Anesthesiology, Anesthesiology, General, Vascular, High Risk Transplant & Critical Care, Anesthesiology 2011 - 2020
- Associate Professor of Anesthesiology, Anesthesiology, General, Vascular, High Risk Transplant & Critical Care, Anesthesiology 2007 - 2011
- Assistant Professor of Anesthesiology, Anesthesiology, General, Vascular, High Risk Transplant & Critical Care, Anesthesiology 2006 - 2007
- Assistant Clinical Professor of Anesthesiology, Anesthesiology, General, Vascular, High Risk Transplant & Critical Care, Anesthesiology 2002 - 2006
- Associate in the Department of Anesthesiology, Anesthesiology, General, Vascular, High Risk Transplant & Critical Care, Anesthesiology 1998 - 2002
Recognition
Awards & Honors
Expertise
Subject Headings
Research
Selected Grants
- Right Place, Right Time: Information Design to Support Decisions in Acute Care awarded by Saint Alphonsus Regional Medical Center 2015 - 2018
- Toward intelligent display of health data: A qualitative study of use patterns awarded by National Institutes of Health 2011 - 2015
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Browndyke, Jeffrey N., Mary C. Wright, Rosa Yang, Ayesha Syed, John Park, Ashley Hall, Katherine Martucci, et al. “Corrigendum to 'Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study' (Br J Anaesth 2021; 127: 917-928).” Br J Anaesth 130, no. 5 (May 2023): 646. https://doi.org/10.1016/j.bja.2023.02.009.
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  - Berger, Miles, Jeffrey N. Browndyke, Mary Cooter Wright, Chloe Nobuhara, Melody Reese, Leah Acker, W Michael Bullock, et al. “Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.” Ann Clin Transl Neurol 9, no. 2 (February 2022): 155–70. https://doi.org/10.1002/acn3.51499.
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  - Oyeyemi, Deborah M., Mary Cooter, Stacey Chung, Heather E. Whitson, Jeffrey N. Browndyke, Michael J. Devinney, Patrick J. Smith, et al. “Relationship Between Depression/Anxiety and Cognitive Function Before and 6 Weeks After Major Non-Cardiac Surgery in Older Adults.” J Geriatr Psychiatry Neurol 35, no. 1 (January 2022): 145–54. https://doi.org/10.1177/0891988720978791.
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  - Browndyke, Jeffrey N., Mary C. Wright, Rosa Yang, Ayesha Syed, John Park, Ashley Hall, Katherine Martucci, et al. “Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study.” Br J Anaesth 127, no. 6 (December 2021): 917–28. https://doi.org/10.1016/j.bja.2021.08.012.
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  - Terrando, Niccolò, John J. Park, Michael Devinney, Cliburn Chan, Mary Cooter, Pallavi Avasarala, Joseph P. Mathew, et al. “Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults.” Sci Rep 11, no. 1 (February 4, 2021): 3047. https://doi.org/10.1038/s41598-021-82606-5.
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  - VanDusen, Keith W., Yi-Ju Li, Victor Cai, Ashley Hall, Sarah Hiles, J Will Thompson, M Arthur Moseley, et al. “Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.” J Alzheimers Dis 80, no. 3 (2021): 1281–97. https://doi.org/10.3233/JAD-201544.
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  - Nobuhara, Chloe K., W Michael Bullock, Thomas Bunning, Brian Colin, Mary Cooter, Michael J. Devinney, Michael N. Ferrandino, et al. “A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.” J Neurol 267, no. 7 (July 2020): 2002–6. https://doi.org/10.1007/s00415-020-09797-1.
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  - VanDusen, Keith W., Sarada Eleswarpu, Eugene W. Moretti, Michael J. Devinney, Donna M. Crabtree, Daniel T. Laskowitz, Marty G. Woldorff, et al. “The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.” J Alzheimers Dis 75, no. 4 (2020): 1319–28. https://doi.org/10.3233/JAD-191185.
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  - Berger, Miles, David M. Murdoch, Janet S. Staats, Cliburn Chan, Jake P. Thomas, Grant E. Garrigues, Jeffrey N. Browndyke, et al. “Flow Cytometry Characterization of Cerebrospinal Fluid Monocytes in Patients With Postoperative Cognitive Dysfunction: A Pilot Study.” Anesth Analg 129, no. 5 (November 2019): e150–54. https://doi.org/10.1213/ANE.0000000000004179.
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  - Berger, Miles, Deborah Oyeyemi, Mobolaji O. Olurinde, Heather E. Whitson, Kent J. Weinhold, Marty G. Woldorff, Lewis A. Lipsitz, et al. “The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.” J Am Geriatr Soc 67, no. 4 (April 2019): 794–98. https://doi.org/10.1111/jgs.15770.
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  - Giattino, Charles M., Jacob E. Gardner, Faris M. Sbahi, Kenneth C. Roberts, Mary Cooter, Eugene Moretti, Jeffrey N. Browndyke, et al. “Intraoperative Frontal Alpha-Band Power Correlates with Preoperative Neurocognitive Function in Older Adults.” Front Syst Neurosci 11 (2017): 24. https://doi.org/10.3389/fnsys.2017.00024.
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  - Wright, Melanie C., Sherry Dunbar, Brekk C. Macpherson, Eugene W. Moretti, Guillherme Del Fiol, Jean Bolte, Jeffrey M. Taekman, and Noa Segall. “Toward Designing Information Display to Support Critical Care. A Qualitative Contextual Evaluation and Visioning Effort.” Appl Clin Inform 7, no. 4 (October 5, 2016): 912–29. https://doi.org/10.4338/ACI-2016-03-RA-0033.
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  - Ikeda, Keita, David B. MacLeod, Hilary P. Grocott, Eugene W. Moretti, Warwick Ames, and Charles Vacchiano. “The accuracy of a near-infrared spectroscopy cerebral oximetry device and its potential value for estimating jugular venous oxygen saturation.” Anesth Analg 119, no. 6 (December 2014): 1381–92. https://doi.org/10.1213/ANE.0000000000000463.
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  - Ginde, Adit A., Patrick J. Blatchford, Stephen Trzeciak, Judd E. Hollander, Robert Birkhahn, Ronny Otero, Tiffany M. Osborn, et al. “Age-related differences in biomarkers of acute inflammation during hospitalization for sepsis.” Shock 42, no. 2 (August 2014): 99–107. https://doi.org/10.1097/SHK.0000000000000182.
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  - Olson, DaiWai M., Meg G. Zomorodi, Michael L. James, Christopher E. Cox, Eugene W. Moretti, Kristina E. Riemen, and Carmelo Graffagnino. “Exploring the impact of augmenting sedation assessment with physiologic monitors.” Aust Crit Care 27, no. 3 (August 2014): 145–50. https://doi.org/10.1016/j.aucc.2013.09.001.
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  - Miller, Timothy E., Julie K. Thacker, William D. White, Christopher Mantyh, John Migaly, Juying Jin, Anthony M. Roche, et al. “Reduced length of hospital stay in colorectal surgery after implementation of an enhanced recovery protocol.” Anesth Analg 118, no. 5 (May 2014): 1052–61. https://doi.org/10.1213/ANE.0000000000000206.
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  - Arroliga, A., R. Balk, C. Cannon, N. Dean, P. Dellinger, P. Dennen, J. Figueroa, et al. “Erratum: A phase 2 randomized, double-blind, placebo-controlled study of the safety and efficacy of talactoferrin in patients with severe sepsis.” Critical Care Medicine 42, no. 5 (January 1, 2014). https://doi.org/10.1097/CCM.0000000000000348.
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  - Funk, D. J., J. Palma Vargas, J. Tuttle-Newhall, and E. W. Moretti. “The use of recombinant human activated protein C (drotrecogin alpha) in solid organ transplant recipients: case series and review of the literature.” Transpl Infect Dis 13, no. 6 (December 2011): 592–97. https://doi.org/10.1111/j.1399-3062.2011.00636.x.
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  - Perman, Sarah M., Anna Marie Chang, Judd E. Hollander, David F. Gaieski, Stephen Trzeciak, Robert Birkhahn, Ronny Otero, et al. “Relationship between B-type natriuretic peptide and adverse outcome in patients with clinical evidence of sepsis presenting to the emergency department.” Acad Emerg Med 18, no. 2 (February 2011): 219–22. https://doi.org/10.1111/j.1553-2712.2010.00968.x.
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  - Moretti, Eugene W. “Interleukin-1 receptor-associated kinase-1: more evidence.” Crit Care Med 38, no. 12 (December 2010): 2410–11. https://doi.org/10.1097/CCM.0b013e3181feb5fc.
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  - Shapiro, Nathan I., Stephen Trzeciak, Judd E. Hollander, Robert Birkhahn, Ronny Otero, Tiffany M. Osborn, Eugene Moretti, et al. “The diagnostic accuracy of plasma neutrophil gelatinase-associated lipocalin in the prediction of acute kidney injury in emergency department patients with suspected sepsis.” Ann Emerg Med 56, no. 1 (July 2010): 52-59.e1. https://doi.org/10.1016/j.annemergmed.2010.02.010.
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  - Funk, D. J., E. W. Moretti, and T. J. Gan. “In response.” Anesthesia and Analgesia 110, no. 1 (January 1, 2010): 258. https://doi.org/10.1213/ANE.0b013e3181c13606.
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  - Bender, Janelle E., Allan B. Shang, Eugene W. Moretti, Bing Yu, Lisa M. Richards, and Nirmala Ramanujam. “Noninvasive monitoring of tissue hemoglobin using UV-VIS diffuse reflectance spectroscopy: a pilot study.” Opt Express 17, no. 26 (December 21, 2009): 23396–409. https://doi.org/10.1364/OE.17.023396.
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  - Archer, Thomas L., Duane J. Funk, Eugene Moretti, and Tong J. Gan. “Stroke volume calculation by esophageal Doppler integrates velocity over time and multiplies this "area under the curve" by the cross sectional area of the aorta.” Anesth Analg 109, no. 3 (September 2009): 996. https://doi.org/10.1213/ane.0b013e3181ae901c.
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  - Funk, Duane J., Eugene W. Moretti, and Tong J. Gan. “Minimally invasive cardiac output monitoring in the perioperative setting.” Anesth Analg 108, no. 3 (March 2009): 887–97. https://doi.org/10.1213/ane.0b013e31818ffd99.
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  - Shapiro, Nathan I., Stephen Trzeciak, Judd E. Hollander, Robert Birkhahn, Ronny Otero, Tiffany M. Osborn, Eugene Moretti, et al. “A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis.” Crit Care Med 37, no. 1 (January 2009): 96–104. https://doi.org/10.1097/CCM.0b013e318192fd9d.
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  - Funk, Duane J., Eugenio Lujan, Eugene W. Moretti, John Davies, Christopher C. Young, Mayur B. Patel, and Steven N. Vaslef. “A brief report: the use of high-frequency oscillatory ventilation for severe pulmonary contusion.” J Trauma 65, no. 2 (August 2008): 390–95. https://doi.org/10.1097/TA.0b013e31817f283f.
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  - Funk, D. J., E. Lujan, E. W. Moretti, J. Davies, C. C. Young, M. B. Patel, and S. N. Vaslef. “A brief report: the use of high-frequency oscillatory ventilation for severe pulmonary contusion.” The Journal of Trauma 65, no. 2 (August 1, 2008): 390–95.
  - Moretti, Eugene W., Mark F. Newman, Lawrence H. Muhlbaier, David Whellan, Rebecca P. Petersen, Daniel Rossignol, Charles B. McCants, Barbara Phillips-Bute, and Elliott Bennett-Guerrero. “Effects of decreased preoperative endotoxin core antibody levels on long-term mortality after coronary artery bypass graft surgery.” Arch Surg 141, no. 7 (July 2006): 637–41. https://doi.org/10.1001/archsurg.141.7.637.
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  - Moretti, Eugene W., Richard W. Morris, Mihai Podgoreanu, Debra A. Schwinn, Mark F. Newman, Ellen Bennett, Victor G. Moulin, Uzo U. Mba, Daniel T. Laskowitz, and Daniel T. Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. “APOE polymorphism is associated with risk of severe sepsis in surgical patients.” Crit Care Med 33, no. 11 (November 2005): 2521–26. https://doi.org/10.1097/01.ccm.0000186368.96146.fb.
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  - Moretti, E. W., C. L. Ofstead, R. M. Kristy, and H. P. Wetzler. “Impact of central venous catheter type and methods on catheter-related colonization and bacteraemia.” J Hosp Infect 61, no. 2 (October 2005): 139–45. https://doi.org/10.1016/j.jhin.2005.02.012.
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  - Cortinez, Luis I., Jacques Somma, Kerri M. Robertson, John C. Keifer, David R. Wright, Yung-Wei Hsu, David B. MacLeod, and Eugene W. Moretti. “Changes in hematocrit based on incremental blood sampling: mathematical models perform poorly.” Can J Anaesth 52, no. 4 (April 2005): 374–78. https://doi.org/10.1007/BF03016279.
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  - MacLeod, D. B., L. I. Cortinez, J. C. Keifer, D. Cameron, D. R. Wright, W. D. White, E. W. Moretti, L. R. Radulescu, and J. Somma. “The desaturation response time of finger pulse oximeters during mild hypothermia.” Anaesthesia 60, no. 1 (January 2005): 65–71. https://doi.org/10.1111/j.1365-2044.2004.04033.x.
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  - Cortinez, Luis I., Yung-Wei Hsu, Sam T. Sum-Ping, Christopher Young, John C. Keifer, David Macleod, Kerri M. Robertson, David R. Wright, Eugene W. Moretti, and Jacques Somma. “Dexmedetomidine pharmacodynamics: Part II: Crossover comparison of the analgesic effect of dexmedetomidine and remifentanil in healthy volunteers.” Anesthesiology 101, no. 5 (November 2004): 1077–83. https://doi.org/10.1097/00000542-200411000-00006.
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  - Hsu, Yung-Wei, Luis I. Cortinez, Kerri M. Robertson, John C. Keifer, Sam T. Sum-Ping, Eugene W. Moretti, Christopher C. Young, David R. Wright, David B. Macleod, and Jacques Somma. “Dexmedetomidine pharmacodynamics: part I: crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers.” Anesthesiology 101, no. 5 (November 2004): 1066–76. https://doi.org/10.1097/00000542-200411000-00005.
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  - Horowitz, Peter E., and Avinash Kumar. “It's the colloid, not the esophageal Doppler monitor.” Anesthesiology 99, no. 1 (July 2003): 238–39. https://doi.org/10.1097/00000542-200307000-00045.
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  - Lanzinger, Marcella J., Eugene W. Moretti, Robert F. Wilderman, Habib E. El-Moalem, John G. Toffaletti, and Richard E. Moon. “The relationship between ionized and total serum magnesium concentrations during abdominal surgery.” J Clin Anesth 15, no. 4 (June 2003): 245–49. https://doi.org/10.1016/s0952-8180(03)00059-x.
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  - Moretti, Eugene W., Kerri M. Robertson, Habib El-Moalem, and Tong J. Gan. “Intraoperative colloid administration reduces postoperative nausea and vomiting and improves postoperative outcomes compared with crystalloid administration.” Anesth Analg 96, no. 2 (February 2003): 611–17. https://doi.org/10.1097/00000539-200302000-00056.
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  - Gan, Tong J., Andrew Soppitt, Mohamed Maroof, Habib el-Moalem, Kerri M. Robertson, Eugene Moretti, Peter Dwane, and Peter S. A. Glass. “Goal-directed intraoperative fluid administration reduces length of hospital stay after major surgery.” Anesthesiology 97, no. 4 (October 2002): 820–26. https://doi.org/10.1097/00000542-200210000-00012.
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  - Moretti, Eugene W., Kerri M. Robertson, J. E. Tuttle-Newhall, Pierre-Alain Clavien, and Tong-Joo Gan. “Orthotopic liver transplant patients require less postoperative morphine than do patients undergoing hepatic resection.” J Clin Anesth 14, no. 6 (September 2002): 416–20. https://doi.org/10.1016/s0952-8180(02)00390-2.
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  - Stephenson, G. R., E. W. Moretti, H. El-Moalem, P. A. Clavien, and J. E. Tuttle-Newhall. “Malnutrition in liver transplant patients: preoperative subjective global assessment is predictive of outcome after liver transplantation.” Transplantation 72, no. 4 (August 27, 2001): 666–70. https://doi.org/10.1097/00007890-200108270-00018.
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- Book Sections
  - Joseph, D. O., J. L. Myers, and E. W. Moretti. “Vein anesthesia.” In Phlebology, Vein Surgery and Ultrasonography: Diagnosis and Management of Venous Disease, 369–75, 2014. https://doi.org/10.1007/978-3-319-01812-6_26.
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- Conference Papers
  - Reese, T. J., K. Kawamoto, G. D. Fiol, C. Weir, J. Tonna, N. Segall, P. Nesbitt, et al. “Approaching the Design of an Information Display to Support Critical Care.” In Proceedings 2017 Ieee International Conference on Healthcare Informatics, Ichi 2017, 439–43, 2017. https://doi.org/10.1109/ICHI.2017.64.
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Education, Training, & Certifications

Previous Appointments & Affiliations

Awards & Honors

Subject Headings

Selected Grants

Selected Publications

Academic Articles

Book Sections

Conference Papers