Scholars@Duke
Mridul Bhattarai

Selected Publications

Iodine quantification performance with deep silicon-based Photon-Counting CT: A virtual imaging trial study.

Journal Article Phys Med · June 6, 2025 PURPOSE: This study investigates the imaging performance of a deep silicon-based photon-counting CT (Si-PCCT) in quantifying iodine contrast through a virtual imaging trial (VIT). METHODS: We developed a VIT framework using Si-PCCT simulator and benchmarke ... Full text Link to item Cite

Quantitative Accuracy of CT Protocols for Cross-sectional and Longitudinal Assessment of COPD: A Virtual Imaging Study.

Journal Article Proc SPIE Int Soc Opt Eng · February 2025 Chronic obstructive pulmonary disease (COPD), encompassing chronic bronchitis and emphysema, requires precise quantification through CT imaging to accurately assess disease severity and progression. However, inconsistencies in imaging protocols often lead ... Full text Link to item Cite

A framework to model charge sharing and pulse pileup for virtual imaging trials of photon-counting CT.

Journal Article Phys Med Biol · November 6, 2024 Objective.This study describes the development, validation, and integration of a detector response model that accounts for the combined effects of x-ray crosstalk, charge sharing, and pulse pileup in photon-counting detectors.Approach.The x-ray photon tran ... Full text Link to item Cite

A systematic task-based image quality assessment of photon-counting and energy integrating CT as a function of reconstruction kernel and phantom size.

Journal Article Med Phys · February 2024 BACKGROUND: Image quality of photon-counting and energy integrating CT scanners changes with object size, dose to the object, and kernel selection. PURPOSE: To comprehensively compare task-generic image quality of photon-counting CT (PCCT) and energy integ ... Full text Link to item Cite

A generic model of semiconductor-based photon-counting detectors for spectral CT

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2024 Photon-counting CT (PCCT) is an emerging x-ray spectral imaging technology. There are several PCCT prototypes available for clinical and experimental applications. Despite many published results, objective quantitative evaluation of PCCT systems remains ch ... Full text Cite

Performance assessment of photon counting versus energy integrated CT: concordance of in vivo and phantom measurements

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2024 Photon-counting CT (PCCT) and energy-integrating CT (EICT) system offer differing image quality attributes, but it is uncertain if such attributes manifest themselves differently across phantom vs patients. This study investigated if image quality assessme ... Full text Cite

Exploration of the pulse pileup effects in a clinical CdTe-based photon-counting computed tomography.

Journal Article Med Phys · November 2023 BACKGROUND: High tube current generates a high flux of x-rays to photon counting detectors (PCDs) that can potentially result in the piling up of pulses formed by concurrent photons, which can cause count loss and energy resolution degradation. PURPOSE: To ... Full text Link to item Cite

Simulation of the combined effects of charge sharing and pulse pileup in photon-counting CT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2022 Photon-counting CT (PCCT) is an emerging CT technology that uses photon-counting detectors (PCDs) to offer better spatial resolution, higher contrast, lower noise, and material-specific imaging as compared to conventional energy-integrating CT. To study th ... Full text Cite