Scholars@Duke
Nada Kais El Husseini

Nada Kais El Husseini

Associate Professor of Neurology
Neurology, Stroke and Vascular Neurology
nada.elhusseini@duke.edu
Box 31217 Med Ctr, Durham, NC 27710
Dept of Neurology, Durham, NC 27710

Selected Publications

Genetic Variation and Stroke Recovery: The STRONG Study.

Journal Article Stroke · August 2024 BACKGROUND: Genetic association studies can reveal biology and treatment targets but have received limited attention for stroke recovery. STRONG (Stroke, Stress, Rehabilitation, and Genetics) was a prospective, longitudinal (1-year), genetic study in adult ... Full text Link to item Cite

Retinal vessel caliber and cognitive performance: the multi-ethnic study of atherosclerosis (MESA).

Journal Article Sci Rep · February 19, 2024 Retinal vessel calibers share anatomic and physiologic characteristics with the cerebral vasculature and can be visualized noninvasively. In light of the known microvascular contributions to brain health and cognitive function, we aimed to determine if, in ... Full text Link to item Cite

Strategies to Reduce Racial and Ethnic Inequities in Stroke Preparedness, Care, Recovery, and Risk Factor Control: A Scientific Statement From the American Heart Association.

Journal Article Stroke · July 2023 Stroke is a disease of disparities, with tremendous racial and ethnic inequities in incidence, prevalence, treatment, and outcomes. The accumulating literature on the relationship between stroke and social determinants of health (ie, the structural conditi ... Full text Link to item Cite

Cognitive Impairment After Ischemic and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association/American Stroke Association.

Journal Article Stroke · June 2023 PURPOSE: Cognitive impairment is a common consequence of stroke and has direct implications for poststroke functioning and quality of life, including the ability to maintain a job, live independently, sustain interpersonal relationships, and drive a vehicl ... Full text Link to item Cite

Rehabilitation Therapy Doses Are Low After Stroke and Predicted by Clinical Factors.

Journal Article Stroke · March 2023 BACKGROUND: Stroke is a leading cause of long-term disability. Greater rehabilitation therapy after stroke is known to improve functional outcomes. This study examined therapy doses during the first year of stroke recovery and identified factors that predi ... Full text Link to item Cite

The hypereosinophilic syndrome - an unusual cause of myocarditis and cardioembolic strokes.

Journal Article Am J Med Sci · November 2022 Hypereosinophilic syndrome is a rare disorder characterized by excessive peripheral eosinophilia and eosinophil associated end-organ damage. Clinical presentations are heterogenous and can involve skin, pulmonary, cardiac and neurologic dysfunction. Eosino ... Full text Link to item Cite

Association of in-hospital depression and anxiety symptoms following stroke with 3 months- depression, anxiety and functional outcome.

Journal Article J Clin Neurosci · April 2022 BACKGROUND: Post-stroke depression and anxiety are common and are associated with worse post-stroke outcomes. Even though checking for depression during stroke hospitalization has become a common practice, the prognostic value of a positive in-hospital dep ... Full text Link to item Cite

Effects of Fragmentation and the Case for Greater Cohesion in Neurologic Care Delivery.

Journal Article Neurology · January 24, 2022 GOALS: To define fragmentation in neurologic care delivery, explain the positive and negative drivers in neurologic practice that contribute to fragmentation, illustrate situations that increase fragmentation risk, emphasize the costs and impact on both pa ... Full text Link to item Cite

Alternative Payment Models and Associations With Stroke Outcomes, Spending, and Service Utilization: A Systematic Review.

Journal Article Stroke · January 2022 Stroke contributes an estimated $28 billion to US health care costs annually, and alternative payment models aim to improve outcomes and lower spending over fee-for-service by aligning economic incentives with high value care. This systematic review evalua ... Full text Link to item Cite

Accelerated Mineralization as a Mimic of Hemorrhagic Conversion

Journal Article Neurology: Clinical Practice · February 1, 2021 A 65-year old man was admitted to the neurocritical care unit for possible hemorrhagic transformation of a recent left middle cerebral artery (MCA) stroke. His medical history was notable for atrial fibrillation, end-stage renal disease (ESRD) on hemodialy ... Full text Cite

Vascular Cellular Adhesion Molecule-1 (VCAM-1) and Memory Impairment in African-Americans after Small Vessel-Type Stroke.

Journal Article J Stroke Cerebrovasc Dis · April 2020 BACKGROUND: African-Americans (AA) are 3 times more likely to have small-vessel-type ischemic strokes (SVS) than Whites. Small vessel strokes are associated with cognitive impairment, a relationship incompletely explained by white matter hyperintensity (WM ... Full text Link to item Cite

Association of Kidney Function With 30-Day and 1-Year Poststroke Mortality and Hospital Readmission.

Journal Article Stroke · December 2018 Background and Purpose- Kidney dysfunction is common among patients hospitalized for ischemic stroke. Understanding the association of kidney disease with poststroke outcomes is important to properly adjust for case mix in outcome studies, payment models a ... Full text Link to item Cite

Association of IL6ST (gp130) Polymorphism with Functional Outcome Following Spontaneous Intracerebral Hemorrhage.

Journal Article J Stroke Cerebrovasc Dis · January 2018 BACKGROUND AND PURPOSE: Genes associated with the inflammatory response and cytostructural integrity may influence recovery following a brain injury. To examine this in the setting of spontaneous intracerebral hemorrhage (ICH), selected single nucleotide p ... Full text Link to item Cite

Depression Status Is Associated with Functional Decline Over 1-Year Following Acute Stroke.

Journal Article J Stroke Cerebrovasc Dis · July 2017 BACKGROUND: We investigated the independent association of depression status at 3 and 12 months after stroke and functional decline. METHODS: Data were obtained as part of the multicenter Adherence eValuation After Ischemic stroke Longitudinal (AVAIL) regi ... Full text Link to item Cite

Poststroke Depression: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association.

Journal Article Stroke · February 2017 Poststroke depression (PSD) is common, affecting approximately one third of stroke survivors at any one time after stroke. Individuals with PSD are at a higher risk for suboptimal recovery, recurrent vascular events, poor quality of life, and mortality. Al ... Full text Link to item Cite

Renal Dysfunction Is Associated With Poststroke Discharge Disposition and In-Hospital Mortality: Findings From Get With The Guidelines-Stroke.

Journal Article Stroke · February 2017 BACKGROUND AND PURPOSE: Kidney disease is a frequent comorbidity in patients presenting with acute ischemic stroke. We evaluated whether the estimated glomerular filtration rate (eGFR) on admission is associated with poststroke in-hospital mortality or dis ... Full text Link to item Cite

Treating In-Hospital Stroke.

Journal Article JAMA Neurol · December 2015 Full text Link to item Cite

Comparison of Acoustic Radiation Force Impulse Imaging Derived Carotid Plaque Stiffness With Spatially Registered MRI Determined Composition.

Journal Article IEEE Trans Med Imaging · November 2015 Measurements of plaque stiffness may provide important prognostic and diagnostic information to help clinicians distinguish vulnerable plaques containing soft lipid pools from more stable, stiffer plaques. In this preliminary study, we compare in vivo ultr ... Full text Link to item Cite

Chronic kidney disease and stroke.

Journal Article Adv Chronic Kidney Dis · November 2014 Chronic kidney disease (CKD) is associated with an increased risk of both ischemic and hemorrhagic stroke. In addition to shared risk factors, this higher cerebrovascular risk is mediated by several CKD-associated mechanisms including platelet dysfunction, ... Full text Link to item Cite

The role of neuroendocrine pathways in prognosis after stroke.

Journal Article Expert Rev Neurother · February 2014 A number of neuroendocrine changes have been described after stroke, which may serve adaptive or deleterious functions. The neuroendocrine changes include activation of the hypothalamo-pituitary-adrenal axis, sympathetic nervous system and alterations of s ... Full text Link to item Cite

Approaches to antifungal therapies and their effectiveness among patients with cryptococcosis.

Journal Article Antimicrob Agents Chemother · June 2013 The goal of this study was to determine the degree to which the persistence of cryptococcosis, overall 1-year mortality, and 1-year mortality due to cryptococcosis were influenced by initial antifungal treatment regimen in a cohort of adults with cryptococ ... Full text Link to item Cite

"Code stroke": hospitalized versus emergency department patients.

Journal Article J Stroke Cerebrovasc Dis · May 2013 Stroke rapid-response ("code stroke") teams facilitate the evaluation and treatment of patients presenting to emergency departments (EDs). Little is known about the usefulness of code stroke systems for patients hospitalized primarily for other conditions. ... Full text Link to item Cite

Depression and antidepressant use after stroke and transient ischemic attack.

Journal Article Stroke · June 2012 BACKGROUND AND PURPOSE: Patients with stroke and transient ischemic attack (TIA) often have comparable comorbidities, but it is unclear whether they have similar rates of depression or antidepressant use. METHODS: This study was a secondary analysis of a p ... Full text Link to item Cite

Comparison and temporal trends of three groups with cryptococcosis: HIV-infected, solid organ transplant, and HIV-negative/non-transplant.

Journal Article PLoS One · 2012 BACKGROUND: The Infectious Disease Society of America (IDSA) 2010 Clinical Practice Guidelines for the management of cryptococcosis outlined three key populations at risk of disease: (1) HIV-infected, (2) transplant recipient, and (3) HIV-negative/non-tran ... Full text Link to item Cite

[Neurology and cardiology: points of contact].

Journal Article Rev Esp Cardiol · April 2011 Strokes resulting from cardiac diseases, and cardiac abnormalities associated with neuromuscular disorders are examples of the many points of contact between neurology and cardiology. Approximately 20-30% of strokes are related to cardiac diseases, includi ... Full text Link to item Cite

Concerns for the reliability and validity of the National Stroke Project Stroke Severity Scale.

Journal Article Cerebrovasc Dis · 2011 BACKGROUND: The National Stroke Project (NSP) was a retrospective cohort study of US Medicare beneficiaries hospitalized with stroke or transient ischemic attack (TIA). The NSP included a simple assessment of stroke severity (NSP-Stroke Scale, NSP-SS). Use ... Full text Link to item Cite

Clinical application of blood biomarkers in cerebrovascular disease.

Journal Article Expert Rev Neurother · February 2010 Identifying a biomarker or panel of biomarkers of cerebral ischemia would have a major impact on the care of stroke patients by facilitating early management decisions and individualization of care. Biochemical surrogates of cerebral ischemia might also pl ... Full text Link to item Cite

Echocardiographically detected mass "in transit" in early amniotic fluid embolism.

Journal Article Eur J Echocardiogr · August 2006 BACKGROUND: Amniotic fluid embolism is a catastrophic illness related to the passage of fetal material into the pulmonary circulation causing cardiovascular collapse. CASE: A 29-year-old female sustained cardiopulmonary arrest during delivery presumably du ... Full text Link to item Cite