Mark Franklin Newman | Scholars@Duke

Mark Franklin Newman
Merel H. Harmel Distinguished Professor Emeritus of Anesthesiology

Best known for his work in assessing and improving clinical outcomes and quality of life following cardiac surgery, Dr. Mark Newman is President of the Duke Private Diagnostic Clinic (The Duke Faculty Practice Organization) and the Merel H. Harmel Professor of Anesthesiology at Duke University Medical Center. In addition, Dr. Newman developed the Multicenter Perioperative Outcomes Research Group of the Duke Clinical Research Institute established at Duke in 2001 to further the study of strategies to improve the outcomes of patients undergoing surgery and anesthesia. Dr. Newman has received funding from the National Institute on Aging, the American Heart Association, the National Heart, Lung and Blood Institute, the Anesthesia Patient Safety Foundation, and the International Anesthesia Research Society to investigate the impact of perioperative outcomes (neurocognitive decline, stroke, myocardial infarction, renal injury) on quantity and quality of life following cardiac surgery and resulting in numerous seminal publications in the New England Journal of Medicine , JAMA and Lancet. Dr. Newman is a popular lecturer and speaker, having appeared on NBC Nightly News and The Today Show and having spoken at more than 200 national and international meetings. Dr. Newman recently stepped down as the Chairman of the Duke University Department after 13 years to assume the role of PDC President. During Dr. Newman’s tenure the department grew exponentially doubling its clinical and academic funding, and developing many outstanding individuals that have gone on to leadership roles at Duke and other key academic institutions across the country.

Current Appointments & Affiliations

Merel H. Harmel Distinguished Professor Emeritus of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2017
Professor Emeritus of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2017
Member in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 1997

Contact Information

200 Trent Drive, 1293 Orange Zone, Durham, NC 27710
Box 3810, 1293 Orange Zone, Duke South, Durham, NC 27710
newma005@mc.duke.edu (919) 681-6581

Background
Education, Training, & Certifications
- M.D., University of Louisville 1985
Previous Appointments & Affiliations
- Professor of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 1999 - 2017
- Professor of Medicine, Medicine, Cardiology, Medicine 2003 - 2017
- Merel H. Harmel Distinguished Professor of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2004 - 2017
- Chair, Department of Anesthesiology, Anesthesiology, Clinical Science Departments 2001 - 2014
- Chief, Division of Anesthesiology Cardiac Service in the Department of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 1994 - 2006
- Associate Professor in Medicine, Medicine, Cardiology, Medicine 1999 - 2003
- Assistant Professor of Medicine, Medicine, Cardiology, Medicine 1995 - 1999
- Associate Professor of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 1996 - 1999
- Assistant Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 1992 - 1996
Research
Selected Grants
- Lidocaine for Neuroprotection During Cardiac Surgery awarded by National Institutes of Health 2009 - 2016
- Cortical Beta-amyloid Levels and Neurocognitive Performance After Cardiac Surgery awarded by National Institutes of Health 2011 - 2014
- IPA-Jeffrey Taekman awarded by Veterans Administration Medical Center 2012
- IPA-Noa Segall awarded by Veterans Administration Medical Center 2012
- IPA-Eugene Hobbs awarded by Veterans Administration Medical Center 2008 - 2011
- IPA-Jeffrey Taekman awarded by Veterans Administration Medical Center 2008 - 2011
- IPA-Noa Segall awarded by Veterans Administration Medical Center 2008 - 2011
- Defining the Learning Curve in Research Trials awarded by National Institutes of Health 2004 - 2009
- PeriOperative Interventional Neuroprotection Trial POINT awarded by National Institutes of Health 2001 - 2008
- Creating, Implementing, and Sharing Best Practices for Clinical Trials Networks awarded by National Institutes of Health 2004 - 2008
- Genetics, Inflammation & Post-op Cognitive Dysfunction awarded by National Institutes of Health 1999 - 2006
- Aging And Cognition After Cardiac Surgery awarded by National Institutes of Health 1999 - 2004
- Genetic Basis of Cognitive Decline After Surgery awarded by National Institutes of Health 1997 - 2002
- Genetic Basis Of Cognitive Decline After Surgery awarded by National Institutes of Health 1997 - 1999
- Aging, Cognition And Quality Of Life After Cardiac Surgery awarded by National Institutes of Health 1996 - 1999
- Genetic Basis Of Cognitive Decline After Surgery awarded by National Institutes of Health 1997 - 1999
- Aging And Cognitive After Cardiac Surgery awarded by National Institutes of Health 1996 - 1999
- Aging And Cognition After Cardiac Surgery awarded by National Institutes of Health 1994 - 1999
- Aging And Cognition After Cardiac Surgery awarded by National Institutes of Health 1991 - 1999
Publications & Artistic Works
Selected Publications
- Books
  - Grocott, H. P., M. F. Newman, and M. H. Harmel. Foreword to the first edition, 2012. https://doi.org/10.1017/CBO9780511979095.
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- Academic Articles
  - Conroy, Joanne M., David Lubarsky, and Mark F. Newman. “Anesthesiologists as Health System Leaders: Why It Works.” Anesth Analg 134, no. 2 (February 1, 2022): 235–40. https://doi.org/10.1213/ANE.0000000000005845.
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  - Browndyke, Jeffrey N., Mary C. Wright, Rosa Yang, Ayesha Syed, John Park, Ashley Hall, Katherine Martucci, et al. “Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study.” Br J Anaesth 127, no. 6 (December 2021): 917–28. https://doi.org/10.1016/j.bja.2021.08.012.
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  - Terrando, Niccolò, John J. Park, Michael Devinney, Cliburn Chan, Mary Cooter, Pallavi Avasarala, Joseph P. Mathew, et al. “Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults.” Sci Rep 11, no. 1 (February 4, 2021): 3047. https://doi.org/10.1038/s41598-021-82606-5.
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  - VanDusen, Keith W., Yi-Ju Li, Victor Cai, Ashley Hall, Sarah Hiles, J Will Thompson, M Arthur Moseley, et al. “Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.” J Alzheimers Dis 80, no. 3 (2021): 1281–97. https://doi.org/10.3233/JAD-201544.
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  - Nobuhara, Chloe K., W Michael Bullock, Thomas Bunning, Brian Colin, Mary Cooter, Michael J. Devinney, Michael N. Ferrandino, et al. “A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.” J Neurol 267, no. 7 (July 2020): 2002–6. https://doi.org/10.1007/s00415-020-09797-1.
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  - Edwards, Robert L., Mark D. Birdwhistell, James W. Zembrodt, Mark F. Newman, and Michael Karpf. “Securing a Network for a Research-Intensive, Referral Academic Medical Center: University of Kentucky HealthCare as a Case Study.” Acad Med 94, no. 12 (December 2019): 1895–1902. https://doi.org/10.1097/ACM.0000000000002878.
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  - Berger, Miles, David M. Murdoch, Janet S. Staats, Cliburn Chan, Jake P. Thomas, Grant E. Garrigues, Jeffrey N. Browndyke, et al. “Flow Cytometry Characterization of Cerebrospinal Fluid Monocytes in Patients With Postoperative Cognitive Dysfunction: A Pilot Study.” Anesth Analg 129, no. 5 (November 2019): e150–54. https://doi.org/10.1213/ANE.0000000000004179.
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  - Mathew, Joseph P., Kathleen A. Welsh-Bohmer, and Mark F. Newman. “Nomenclature for Perioperative Cognitive Disorders: Comment.” Anesthesiology 131, no. 2 (August 2019): 443–44. https://doi.org/10.1097/ALN.0000000000002831.
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  - Klinger, Rebecca Y., Mary Cooter, Tiffany Bisanar, Niccolò Terrando, Miles Berger, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, Joseph P. Mathew, and Joseph P. Neurologic Outcomes Research Group of the Duke Heart Center. “Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.” Anesthesiology 130, no. 6 (June 2019): 958–70. https://doi.org/10.1097/ALN.0000000000002668.
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  - Smith, Patrick J., Jeffrey N. Browndyke, Zachary A. Monge, Todd B. Harshbarger, Michael L. James, Jeffrey G. Gaca, John H. Alexander, et al. “Longitudinal Changes in Regional Cerebral Perfusion and Cognition After Cardiac Operation.” Ann Thorac Surg 107, no. 1 (January 2019): 112–18. https://doi.org/10.1016/j.athoracsur.2018.07.056.
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  - Berger, Miles, Niccolò Terrando, S Kendall Smith, Jeffrey N. Browndyke, Mark F. Newman, and Joseph P. Mathew. “Neurocognitive Function after Cardiac Surgery: From Phenotypes to Mechanisms.” Anesthesiology 129, no. 4 (October 2018): 829–51. https://doi.org/10.1097/ALN.0000000000002194.
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  - Ding, Xiruo, Ziad F. Gellad, Chad Mather, Pamela Barth, Eric G. Poon, Mark Newman, and Benjamin A. Goldstein. “Designing risk prediction models for ambulatory no-shows across different specialties and clinics.” J Am Med Inform Assoc 25, no. 8 (August 1, 2018): 924–30. https://doi.org/10.1093/jamia/ocy002.
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  - Waldron, Nathan H., Mary Cooter, Jonathan P. Piccini, Kevin J. Anstrom, Rebecca Y. Klinger, Miklos D. Kertai, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, and Joseph P. Mathew. “Predictive ability of perioperative atrial fibrillation risk indices in cardiac surgery patients: a retrospective cohort study.” Can J Anaesth 65, no. 7 (July 2018): 786–96. https://doi.org/10.1007/s12630-018-1119-x.
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  - Wang, Alice, Angie Wu, Daniel Wojdyla, Renato D. Lopes, L Kristin Newby, Mark F. Newman, Peter K. Smith, and John H. Alexander. “Dual antiplatelet therapy for perioperative myocardial infarction following CABG surgery.” Am Heart J 199 (May 2018): 150–55. https://doi.org/10.1016/j.ahj.2018.02.006.
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  - Klinger, Rebecca Y., Olga G. James, Salvador Borges-Neto, Tiffany Bisanar, Yi-Ju Li, Wenjing Qi, Miles Berger, et al. “18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.” Anesthesiology 128, no. 4 (April 2018): 728–44. https://doi.org/10.1097/ALN.0000000000002103.
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  - Browndyke, Jeffrey N., Miles Berger, Patrick J. Smith, Todd B. Harshbarger, Zachary A. Monge, Viral Panchal, Tiffany L. Bisanar, et al. “Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults.” Hum Brain Mapp 39, no. 2 (February 2018): 985–1003. https://doi.org/10.1002/hbm.23898.
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  - Berger, Miles, Vikram Ponnusamy, Nathaniel Greene, Mary Cooter, Jacob W. Nadler, Allan Friedman, David L. McDonagh, et al. “The Effect of Propofol vs. Isoflurane Anesthesia on Postoperative Changes in Cerebrospinal Fluid Cytokine Levels: Results from a Randomized Trial.” Front Immunol 8 (2017): 1528. https://doi.org/10.3389/fimmu.2017.01528.
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  - Browndyke, Jeffrey N., Miles Berger, Todd B. Harshbarger, Patrick J. Smith, William White, Tiffany L. Bisanar, John H. Alexander, et al. “Resting-State Functional Connectivity and Cognition After Major Cardiac Surgery in Older Adults without Preoperative Cognitive Impairment: Preliminary Findings.” J Am Geriatr Soc 65, no. 1 (January 2017): e6–12. https://doi.org/10.1111/jgs.14534.
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  - Giattino, Charles M., Jacob E. Gardner, Faris M. Sbahi, Kenneth C. Roberts, Mary Cooter, Eugene Moretti, Jeffrey N. Browndyke, et al. “Intraoperative Frontal Alpha-Band Power Correlates with Preoperative Neurocognitive Function in Older Adults.” Front Syst Neurosci 11 (2017): 24. https://doi.org/10.3389/fnsys.2017.00024.
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  - Klinger, Rebecca Y., Mary Cooter, Miles Berger, Mihai V. Podgoreanu, Mark Stafford-Smith, Thomas L. Ortel, Ian J. Welsby, et al. “Effect of intravenous lidocaine on the transcerebral inflammatory response during cardiac surgery: a randomized-controlled trial.” Can J Anaesth 63, no. 11 (November 2016): 1223–32. https://doi.org/10.1007/s12630-016-0704-0.
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  - Berger, Miles, Jacob W. Nadler, Allan Friedman, David L. McDonagh, Ellen R. Bennett, Mary Cooter, Wenjing Qi, et al. “The Effect of Propofol Versus Isoflurane Anesthesia on Human Cerebrospinal Fluid Markers of Alzheimer's Disease: Results of a Randomized Trial.” J Alzheimers Dis 52, no. 4 (April 15, 2016): 1299–1310. https://doi.org/10.3233/JAD-151190.
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  - Kertai, Miklos D., Wenjing Qi, Yi-Ju Li, Frederick W. Lombard, Yutao Liu, Michael P. Smith, Mark Stafford-Smith, et al. “Gene signatures of postoperative atrial fibrillation in atrial tissue after coronary artery bypass grafting surgery in patients receiving β-blockers.” J Mol Cell Cardiol 92 (March 2016): 109–15. https://doi.org/10.1016/j.yjmcc.2016.02.006.
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  - Reves, J. G., and Mark F. Newman. “Merel Harmel: Portrait of an Anesthesiology Pioneer.” Anesth Analg 122, no. 2 (February 2016): 539–41. https://doi.org/10.1213/ANE.0000000000001087.
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  - Klinger, Rebecca Y., Christopher A. Thunberg, William D. White, Manuel Fontes, Nathan H. Waldron, Jonathan P. Piccini, G Chad Hughes, et al. “Intraoperative Magnesium Administration Does Not Reduce Postoperative Atrial Fibrillation After Cardiac Surgery.” Anesth Analg 121, no. 4 (October 2015): 861–67. https://doi.org/10.1213/ANE.0000000000000873.
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  - Stafford-Smith, Mark, Yi-Ju Li, Joseph P. Mathew, Yen-Wei Li, Yunqi Ji, Barbara G. Phillips-Bute, Carmelo A. Milano, et al. “Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci.” Kidney Int 88, no. 4 (October 2015): 823–32. https://doi.org/10.1038/ki.2015.161.
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  - Kertai, Miklos D., Yi-Ju Li, Yunqi Ji, Wenjing Qi, Frederick W. Lombard, Svati H. Shah, William E. Kraus, et al. “Genome-wide association study of new-onset atrial fibrillation after coronary artery bypass grafting surgery.” Am Heart J 170, no. 3 (September 2015): 580-90.e28. https://doi.org/10.1016/j.ahj.2015.06.009.
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  - Bartels, Karsten, Yi-Ju Li, Yen-Wei Li, William D. White, Daniel T. Laskowitz, Miklos D. Kertai, Mark Stafford-Smith, Mihai V. Podgoreanu, Mark F. Newman, and Joseph P. Mathew. “Apolipoprotein epsilon 4 genotype is associated with less improvement in cognitive function five years after cardiac surgery: a retrospective cohort study.” Can J Anaesth 62, no. 6 (June 2015): 618–26. https://doi.org/10.1007/s12630-015-0337-8.
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  - Kertai, Miklos D., Yi-Ju Li, Yen-Wei Li, Yunqi Ji, John Alexander, Mark F. Newman, Peter K. Smith, et al. “Genome-wide association study of perioperative myocardial infarction after coronary artery bypass surgery.” Bmj Open 5, no. 5 (May 6, 2015): e006920. https://doi.org/10.1136/bmjopen-2014-006920.
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  - Weisel, Richard D., Nancy Nussmeier, Mark F. Newman, Ronald G. Pearl, Andrew S. Wechsler, Giuseppe Ambrosio, Bertram Pitt, et al. “Predictors of contemporary coronary artery bypass grafting outcomes.” J Thorac Cardiovasc Surg 148, no. 6 (December 2014): 2720-6.e1-2. https://doi.org/10.1016/j.jtcvs.2014.08.018.
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  - Welsby, Ian J., Barbara Phillips-Bute, Joseph P. Mathew, Mark F. Newman, Richard Becker, Sunil Rao, Carmelo A. Milano, and Mark Stafford-Smith. “ABO blood group influences transfusion and survival after cardiac surgery.” J Thromb Thrombolysis 38, no. 3 (October 2014): 402–8. https://doi.org/10.1007/s11239-013-1045-2.
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  - Fontes, Monique T., David L. McDonagh, Barbara Phillips-Bute, Ian J. Welsby, Mihai V. Podgoreanu, Manuel L. Fontes, Mark Stafford-Smith, Mark F. Newman, Joseph P. Mathew, and Joseph P. Neurologic Outcome Research Group (NORG) of the Duke Heart Center. “Arterial hyperoxia during cardiopulmonary bypass and postoperative cognitive dysfunction.” J Cardiothorac Vasc Anesth 28, no. 3 (June 2014): 462–66. https://doi.org/10.1053/j.jvca.2013.03.034.
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  - McDonagh, David L., Miles Berger, Joseph P. Mathew, Carmelo Graffagnino, Carmelo A. Milano, and Mark F. Newman. “Neurological complications of cardiac surgery.” Lancet Neurol 13, no. 5 (May 2014): 490–502. https://doi.org/10.1016/S1474-4422(14)70004-3.
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  - Kertai, Miklos D., Stephen A. Esper, Igor Akushevich, Deepak Voora, Geoffrey S. Ginsburg, Mark Stafford-Smith, Katherine Grichnik, et al. “Preoperative CYP2D6 metabolism-dependent β-blocker use and mortality after coronary artery bypass grafting surgery.” J Thorac Cardiovasc Surg 147, no. 4 (April 2014): 1368-1375.e3. https://doi.org/10.1016/j.jtcvs.2013.09.067.
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  - Mathew, Joseph P., Daniel T. Laskowitz, and Mark F. Newman. “Response to letter regarding article, "Intraoperative magnesium administration does not improve neurocognitive function after cardiac surgery".” Stroke 45, no. 3 (March 2014): e45. https://doi.org/10.1161/STROKEAHA.113.004025.
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  - Mathew, Joseph P., William D. White, David B. Schinderle, Mihai V. Podgoreanu, Miles Berger, Carmelo A. Milano, Daniel T. Laskowitz, et al. “Intraoperative magnesium administration does not improve neurocognitive function after cardiac surgery.” Stroke 44, no. 12 (December 2013): 3407–13. https://doi.org/10.1161/STROKEAHA.113.002703.
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  - Klinger, Rebecca Y., Olga G. James, Terence Z. Wong, Mark F. Newman, P Murali Doraiswamy, and Joseph P. Mathew. “Cortical β-amyloid levels and neurocognitive performance after cardiac surgery.” Bmj Open 3, no. 9 (September 20, 2013): e003669. https://doi.org/10.1136/bmjopen-2013-003669.
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  - Newman, Mark F., Joseph P. Mathew, and Solomon Aronson. “The evolution of anesthesiology and perioperative medicine.” Anesthesiology 118, no. 5 (May 2013): 1005–7. https://doi.org/10.1097/ALN.0b013e31828ea5cb.
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  - Bartels, Karsten, David L. McDonagh, Mark F. Newman, and Joseph P. Mathew. “Neurocognitive outcomes after cardiac surgery.” Curr Opin Anaesthesiol 26, no. 1 (February 2013): 91–97. https://doi.org/10.1097/ACO.0b013e32835bf24c.
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  - Fontes, Monique T., R Cameron Swift, Barbara Phillips-Bute, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, Joseph P. Mathew, and Joseph P. Neurologic Outcome Research Group of the Duke Heart Center. “Predictors of cognitive recovery after cardiac surgery.” Anesth Analg 116, no. 2 (February 2013): 435–42. https://doi.org/10.1213/ANE.0b013e318273f37e.
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  - Aronson, Solomon, Barbara Phillips-Bute, Mark Stafford-Smith, Manuel Fontes, Jeffrey Gaca, Joseph P. Mathew, and Mark F. Newman. “The association of postcardiac surgery acute kidney injury with intraoperative systolic blood pressure hypotension.” Anesthesiol Res Pract 2013 (2013): 174091. https://doi.org/10.1155/2013/174091.
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  - Newman, Mark F., T Bruce Ferguson, Jennifer A. White, Giuseppe Ambrosio, Joerg Koglin, Nancy A. Nussmeier, Ronald G. Pearl, et al. “Effect of adenosine-regulating agent acadesine on morbidity and mortality associated with coronary artery bypass grafting: the RED-CABG randomized controlled trial.” Jama 308, no. 2 (July 11, 2012): 157–64. https://doi.org/10.1001/jama.2012.7633.
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  - Hsu, Yung-Wei, Jacques Somma, Mark F. Newman, and Joseph P. Mathew. “Population pharmacokinetics of lidocaine administered during and after cardiac surgery.” J Cardiothorac Vasc Anesth 25, no. 6 (December 2011): 931–36. https://doi.org/10.1053/j.jvca.2011.03.008.
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  - Lobato, Robert L., William D. White, Joseph P. Mathew, Mark F. Newman, Peter K. Smith, Charles B. McCants, John H. Alexander, Mihai V. Podgoreanu, and Mihai V. Duke Perioperative Genetics and Safety Outcomes (PEGASUS) Investigative Team. “Thrombomodulin gene variants are associated with increased mortality after coronary artery bypass surgery in replicated analyses.” Circulation 124, no. 11 Suppl (September 13, 2011): S143–48. https://doi.org/10.1161/CIRCULATIONAHA.110.008334.
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  - Aronson, Solomon, Cornelius M. Dyke, Jerrold H. Levy, Albert T. Cheung, Philip D. Lumb, Edwin G. Avery, Ming-yi Hu, and Mark F. Newman. “Does perioperative systolic blood pressure variability predict mortality after cardiac surgery? An exploratory analysis of the ECLIPSE trials.” Anesth Analg 113, no. 1 (July 2011): 19–30. https://doi.org/10.1213/ANE.0b013e31820f9231.
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  - Swaminathan, Madhav, Alina Nicoara, Barbara G. Phillips-Bute, Nicolas Aeschlimann, Carmelo A. Milano, G Burkhard Mackensen, Mihai V. Podgoreanu, et al. “Utility of a simple algorithm to grade diastolic dysfunction and predict outcome after coronary artery bypass graft surgery.” Ann Thorac Surg 91, no. 6 (June 2011): 1844–50. https://doi.org/10.1016/j.athoracsur.2011.02.008.
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  - Lobato, Robert L., William D. White, Joseph P. Mathew, Mark F. Newman, John H. Alexander, and Mihai V. Podgoreanu. “Thrombomodulin Variants are Associated with Increased Mortality following CABG Surgery in Replicated Analyses.” Circulation 122, no. 21 (November 23, 2010).
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  - McDonagh, D. L., J. P. Mathew, W. D. White, and M. F. Newman. “In reply.” Anesthesiology 113, no. 5 (November 1, 2010): 1248–50. https://doi.org/10.1097/ALN.0b013e3181f6a197.
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  - Welsby, Ian J., Evelyn Lockhart, Barbara Phillips-Bute, Mary Lee Campbell, Joseph P. Mathew, Mark F. Newman, Eric Peterson, Carmelo A. Milano, and Carmelo A. Mark Stafford-Smith for members of the Cardiothoracic Anesthesiology Research Endeavors (C.A.R.E.), Department of Anesthesiology, Duke University Medical Center. “Storage age of transfused platelets and outcomes after cardiac surgery.” Transfusion 50, no. 11 (November 2010): 2311–17. https://doi.org/10.1111/j.1537-2995.2010.02747.x.
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  - Taekman, J. M., M. Stafford-Smith, E. J. Velazquez, M. C. Wright, B. G. Phillips-Bute, M. A. Pfeffer, M. A. Sellers, et al. “Departures from the protocol during conduct of a clinical trial: a pattern from the data record consistent with a learning curve.” Qual Saf Health Care 19, no. 5 (October 2010): 405–10. https://doi.org/10.1136/qshc.2008.028605.
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  - Aronson, Solomon, Mark Stafford-Smith, Barbara Phillips-Bute, Andrew Shaw, Jeffrey Gaca, Mark Newman, and Mark Cardiothoracic Anesthesiology Research Endeavors. “Intraoperative systolic blood pressure variability predicts 30-day mortality in aortocoronary bypass surgery patients.” Anesthesiology 113, no. 2 (August 2010): 305–12. https://doi.org/10.1097/ALN.0b013e3181e07ee9.
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  - Welsby, Ian J., Mihai V. Podgoreanu, Barbara Phillips-Bute, Richard Morris, Joseph P. Mathew, Peter K. Smith, Mark F. Newman, Debra A. Schwinn, Mark Stafford-Smith, and Mark Perioperative Genetics and Safety Outcomes Study Investigative Team. “Association of the 98T ELAM-1 polymorphism with increased bleeding after cardiac surgery.” J Cardiothorac Vasc Anesth 24, no. 3 (June 2010): 427–33. https://doi.org/10.1053/j.jvca.2009.10.030.
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  - Swaminathan, Madhav, Christopher C. C. Hudson, Barbara G. Phillips-Bute, Uptal D. Patel, Joseph P. Mathew, Mark F. Newman, Carmelo A. Milano, Andrew D. Shaw, and Mark Stafford-Smith. “Impact of early renal recovery on survival after cardiac surgery-associated acute kidney injury.” Ann Thorac Surg 89, no. 4 (April 2010): 1098–1104. https://doi.org/10.1016/j.athoracsur.2009.12.018.
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  - Nikolov, Nikolay M., Manuel L. Fontes, William D. White, Solomon Aronson, Shahar Bar-Yosef, Jeffrey G. Gaca, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, and Joseph P. Mathew. “Pulse pressure and long-term survival after coronary artery bypass graft surgery.” Anesth Analg 110, no. 2 (February 1, 2010): 335–40. https://doi.org/10.1213/ANE.0b013e3181c76f87.
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  - Bennett-Guerrero, Elliott, Mark Stafford-Smith, Peter M. Waweru, Steven J. Bredehoeft, Mary Lee Campbell, N Rebecca Haley, Barbara Phillips-Bute, Mark F. Newman, and Nicholas Bandarenko. “A prospective, double-blind, randomized clinical feasibility trial of controlling the storage age of red blood cells for transfusion in cardiac surgical patients.” Transfusion 49, no. 7 (July 2009): 1375–83. https://doi.org/10.1111/j.1537-2995.2009.02152.x.
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  - Mathew, Joseph P., G Burkhard Mackensen, Barbara Phillips-Bute, Hilary P. Grocott, Donald D. Glower, Daniel T. Laskowitz, James A. Blumenthal, Mark F. Newman, and Mark F. Neurologic Outcome Research Group (NORG) of the Duke Heart Center. “Randomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgery.” Stroke 40, no. 3 (March 2009): 880–87. https://doi.org/10.1161/STROKEAHA.108.531236.
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  - Phillips-Bute, Barbara, Joseph P. Mathew, James A. Blumenthal, Richard W. Morris, Mihai V. Podgoreanu, Michael Smith, Mark Stafford-Smith, et al. “Relationship of genetic variability and depressive symptoms to adverse events after coronary artery bypass graft surgery.” Psychosom Med 70, no. 9 (November 2008): 953–59. https://doi.org/10.1097/PSY.0b013e318187aee6.
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  - Aronson, Solomon, Cornelius M. Dyke, Kevin A. Stierer, Jerrold H. Levy, Albert T. Cheung, Philip D. Lumb, Dean J. Kereiakes, and Mark F. Newman. “The ECLIPSE trials: comparative studies of clevidipine to nitroglycerin, sodium nitroprusside, and nicardipine for acute hypertension treatment in cardiac surgery patients.” Anesth Analg 107, no. 4 (October 2008): 1110–21. https://doi.org/10.1213/ane.0b013e31818240db.
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  - Singla, Neil, David C. Warltier, Sweeta D. Gandhi, Philip D. Lumb, Robert N. Sladen, Solomon Aronson, Mark F. Newman, Howard L. Corwin, and Howard L. ESCAPE-2 Study Group. “Treatment of acute postoperative hypertension in cardiac surgery patients: an efficacy study of clevidipine assessing its postoperative antihypertensive effect in cardiac surgery-2 (ESCAPE-2), a randomized, double-blind, placebo-controlled trial.” Anesth Analg 107, no. 1 (July 2008): 59–67. https://doi.org/10.1213/ane.0b013e3181732e53.
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  - Shaw, Andrew D., Mark Stafford-Smith, William D. White, Barbara Phillips-Bute, Madhav Swaminathan, Carmelo Milano, Ian J. Welsby, et al. “The effect of aprotinin on outcome after coronary-artery bypass grafting.” N Engl J Med 358, no. 8 (February 21, 2008): 784–93. https://doi.org/10.1056/NEJMoa0707768.
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  - Newman, M. F. “Anaesthesia and the brain.” Southern African Journal of Anaesthesia and Analgesia 14, no. 1 (January 1, 2008): 90. https://doi.org/10.1080/22201173.2008.10872531.
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  - Puskas, Ferenc, Hilary P. Grocott, William D. White, Joseph P. Mathew, Mark F. Newman, and Shahar Bar-Yosef. “Intraoperative hyperglycemia and cognitive decline after CABG.” Ann Thorac Surg 84, no. 5 (November 2007): 1467–73. https://doi.org/10.1016/j.athoracsur.2007.06.023.
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  - Swaminathan, Madhav, Richard W. Morris, Daniel D. De Meyts, Mihai V. Podgoreanu, James G. Jollis, Hilary P. Grocott, Carmelo A. Milano, Mark F. Newman, and Joseph P. Mathew. “Deterioration of regional wall motion immediately after coronary artery bypass graft surgery is associated with long-term major adverse cardiac events.” Anesthesiology 107, no. 5 (November 2007): 739–45. https://doi.org/10.1097/01.anes.0000287008.70453.81.
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  - Mathew, Joseph P., G Burkhard Mackensen, Barbara Phillips-Bute, Mark Stafford-Smith, Mihai V. Podgoreanu, Hilary P. Grocott, Steven E. Hill, et al. “Effects of extreme hemodilution during cardiac surgery on cognitive function in the elderly.” Anesthesiology 107, no. 4 (October 2007): 577–84. https://doi.org/10.1097/01.anes.0000281896.07256.71.
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  - Levy, Jerrold H., Miguel Y. Mancao, Richard Gitter, Dean J. Kereiakes, Alina M. Grigore, Solomon Aronson, and Mark F. Newman. “Clevidipine effectively and rapidly controls blood pressure preoperatively in cardiac surgery patients: the results of the randomized, placebo-controlled efficacy study of clevidipine assessing its preoperative antihypertensive effect in cardiac surgery-1.” Anesth Analg 105, no. 4 (October 2007): 918–25. https://doi.org/10.1213/01.ane.0000281443.13712.b9.
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  - Mathew, Joseph P., Mihai V. Podgoreanu, Hilary P. Grocott, William D. White, Richard W. Morris, Mark Stafford-Smith, G Burkhard Mackensen, et al. “Genetic variants in P-selectin and C-reactive protein influence susceptibility to cognitive decline after cardiac surgery.” J Am Coll Cardiol 49, no. 19 (May 15, 2007): 1934–42. https://doi.org/10.1016/j.jacc.2007.01.080.
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  - Mitchell, John D., Hilary P. Grocott, Barbara Phillips-Bute, Joseph P. Mathew, Mark F. Newman, and Shahar Bar-Yosef. “Cytokine secretion after cardiac surgery and its relationship to postoperative fever.” Cytokine 38, no. 1 (April 2007): 37–42. https://doi.org/10.1016/j.cyto.2007.04.009.
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  - Newman, Mark F. “Open heart surgery and cognitive decline.” Cleve Clin J Med 74 Suppl 1 (February 2007): S52–55. https://doi.org/10.3949/ccjm.74.suppl_1.s52.
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  - Bennett-Guerrero, Elliott, Hilary P. Grocott, Jerrold H. Levy, Kevin A. Stierer, Charles W. Hogue, Albert T. Cheung, Mark F. Newman, Alison A. Carter, Daniel P. Rossignol, and Charles D. Collard. “A phase II, double-blind, placebo-controlled, ascending-dose study of Eritoran (E5564), a lipid A antagonist, in patients undergoing cardiac surgery with cardiopulmonary bypass.” Anesth Analg 104, no. 2 (February 2007): 378–83. https://doi.org/10.1213/01.ane.0000253501.07183.2a.
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  - Doraiswamy, P Murali, Michael A. Babyak, Therese Hennig, Ranak Trivedi, William D. White, Joseph P. Mathew, Mark F. Newman, and James A. Blumenthal. “Donepezil for cognitive decline following coronary artery bypass surgery: a pilot randomized controlled trial.” Psychopharmacol Bull 40, no. 2 (2007): 54–62.
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  - Newman, Mark F., Joseph P. Mathew, Hilary P. Grocott, G Burkhard Mackensen, Terri Monk, Kathleen A. Welsh-Bohmer, James A. Blumenthal, Daniel T. Laskowitz, and Daniel B. Mark. “Central nervous system injury associated with cardiac surgery.” Lancet 368, no. 9536 (August 19, 2006): 694–703. https://doi.org/10.1016/S0140-6736(06)69254-4.
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  - Haverich, Axel, Stanton K. Shernan, Jerrold H. Levy, John C. Chen, Michel Carrier, Kenneth M. Taylor, Frans Van de Werf, et al. “Pexelizumab reduces death and myocardial infarction in higher risk cardiac surgical patients.” Ann Thorac Surg 82, no. 2 (August 2006): 486–92. https://doi.org/10.1016/j.athoracsur.2005.12.035.
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  - Podgoreanu, M. V., W. D. White, R. W. Morris, J. P. Mathew, M. Stafford-Smith, I. J. Welsby, H. P. Grocott, et al. “Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.” Circulation 114, no. 1 Suppl (July 4, 2006): I275–81. https://doi.org/10.1161/CIRCULATIONAHA.105.001032.
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  - Moretti, Eugene W., Mark F. Newman, Lawrence H. Muhlbaier, David Whellan, Rebecca P. Petersen, Daniel Rossignol, Charles B. McCants, Barbara Phillips-Bute, and Elliott Bennett-Guerrero. “Effects of decreased preoperative endotoxin core antibody levels on long-term mortality after coronary artery bypass graft surgery.” Arch Surg 141, no. 7 (July 2006): 637–41. https://doi.org/10.1001/archsurg.141.7.637.
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  - Hill, Steven E., Rebecca A. Keller, Mark Stafford-Smith, Katherine Grichnik, William D. White, Thomas A. D’Amico, and Mark F. Newman. “Efficacy of single-dose, multilevel paravertebral nerve blockade for analgesia after thoracoscopic procedures.” Anesthesiology 104, no. 5 (May 2006): 1047–53. https://doi.org/10.1097/00000542-200605000-00022.
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  - Mathew, Joseph P., Henry M. Rinder, Brian R. Smith, Mark F. Newman, and Christine S. Rinder. “Transcerebral platelet activation after aortic cross-clamp release is linked to neurocognitive decline.” Ann Thorac Surg 81, no. 5 (May 2006): 1644–49. https://doi.org/10.1016/j.athoracsur.2005.12.070.
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  - Stafford-Smith, Mark, and Mark F. Newman. “What effects do hemodilution and blood transfusion during cardiopulmonary bypass have on renal outcomes?” Nat Clin Pract Nephrol 2, no. 4 (April 2006): 188–89. https://doi.org/10.1038/ncpneph0128.
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  - Carrier, M., P. Ménasché, J. H. Levy, M. F. Newman, K. M. Taylor, A. Haverich, J. C. Chen, et al. “Inhibition of complement activation by pexelizumab reduces death in patients undergoing combined aortic valve replacement and coronary artery bypass surgery.” J Thorac Cardiovasc Surg 131, no. 2 (February 2006): 352–56. https://doi.org/10.1016/j.jtcvs.2005.10.011.
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  - Phillips-Bute, Barbara, Joseph P. Mathew, James A. Blumenthal, Hilary P. Grocott, Daniel T. Laskowitz, Robert H. Jones, Daniel B. Mark, and Mark F. Newman. “Association of neurocognitive function and quality of life 1 year after coronary artery bypass graft (CABG) surgery.” Psychosom Med 68, no. 3 (2006): 369–75. https://doi.org/10.1097/01.psy.0000221272.77984.e2.
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  - Wright, Melanie C., Jeffrey M. Taekman, Linda Barber, Gene Hobbs, Mark F. Newman, and Mark Stafford-Smith. “The use of high-fidelity human patient simulation as an evaluative tool in the development of clinical research protocols and procedures.” Contemp Clin Trials 26, no. 6 (December 2005): 646–59. https://doi.org/10.1016/j.cct.2005.09.004.
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  - Moretti, Eugene W., Richard W. Morris, Mihai Podgoreanu, Debra A. Schwinn, Mark F. Newman, Ellen Bennett, Victor G. Moulin, Uzo U. Mba, Daniel T. Laskowitz, and Daniel T. Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. “APOE polymorphism is associated with risk of severe sepsis in surgical patients.” Crit Care Med 33, no. 11 (November 2005): 2521–26. https://doi.org/10.1097/01.ccm.0000186368.96146.fb.
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  - Fleisher, Lee A., Mark F. Newman, Lisa B. St Aubin, Anne B. Cropp, C Bill Billing, Sharon Bonney, William C. Mackey, et al. “Efficacy of zoniporide, an Na/H exchange ion inhibitor, for reducing perioperative cardiovascular events in vascular surgery patients.” J Cardiothorac Vasc Anesth 19, no. 5 (October 2005): 570–76. https://doi.org/10.1053/j.jvca.2005.06.012.
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  - Hill, Steven E., Hilary P. Grocott, Bruce J. Leone, William D. White, Mark F. Newman, and Mark F. Neurologic Outcome Research Group of the Duke Heart Center. “Cerebral physiology of cardiac surgical patients treated with the perfluorocarbon emulsion, AF0144.” Ann Thorac Surg 80, no. 4 (October 2005): 1401–7. https://doi.org/10.1016/j.athoracsur.2005.03.107.
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  - Grocott, Hilary P., William D. White, Richard W. Morris, Mihai V. Podgoreanu, Joseph P. Mathew, Dahlia M. Nielsen, Debra A. Schwinn, Mark F. Newman, and Mark F. Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. “Genetic polymorphisms and the risk of stroke after cardiac surgery.” Stroke 36, no. 9 (September 2005): 1854–58. https://doi.org/10.1161/01.STR.0000177482.23478.dc.
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  - Clark, Jeffrey A., Shahar Bar-Yosef, Amanda Anderson, Mark F. Newman, Kevin Landolfo, and Hilary P. Grocott. “Postoperative hyperthermia following off-pump versus on-pump coronary artery bypass surgery.” J Cardiothorac Vasc Anesth 19, no. 4 (August 2005): 426–29. https://doi.org/10.1053/j.jvca.2005.01.042.
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  - Stafford-Smith, Mark, Edward A. Lefrak, Anjum G. Qazi, Ian J. Welsby, Linda Barber, Andreas Hoeft, Alejandro Dorenbaum, et al. “Efficacy and safety of heparinase I versus protamine in patients undergoing coronary artery bypass grafting with and without cardiopulmonary bypass.” Anesthesiology 103, no. 2 (August 2005): 229–40. https://doi.org/10.1097/00000542-200508000-00005.
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  - Newman, M. F. “Foreward.” Middle East Journal of Anesthesiology 18, no. 2 (June 1, 2005).
  - Mathew, Joseph P., Hilary P. Grocott, James R. McCurdy, Lian K. Ti, R Duane Davis, Daniel T. Laskowitz, Mihai V. Podgoreanu, et al. “Preoperative statin therapy does not reduce cognitive dysfunction after cardiopulmonary bypass.” J Cardiothorac Vasc Anesth 19, no. 3 (June 2005): 294–99. https://doi.org/10.1053/j.jvca.2005.03.004.
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  - Welsby, I. J., M. V. Podgoreanu, B. Phillips-Bute, J. P. Mathew, P. K. Smith, M. F. Newman, D. A. Schwinn, M. Stafford-Smith, and M. Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. “Genetic factors contribute to bleeding after cardiac surgery.” J Thromb Haemost 3, no. 6 (June 2005): 1206–12. https://doi.org/10.1111/j.1538-7836.2005.01337.x.
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  - Lei, Beilei, Daniel P. Morris, Michael P. Smith, Laura P. Svetkey, Mark F. Newman, Jerome I. Rotter, Thomas A. Buchanan, Stephen M. Beckstrom-Sternberg, Eric D. Green, and Debra A. Schwinn. “Novel human alpha1a-adrenoceptor single nucleotide polymorphisms alter receptor pharmacology and biological function.” Naunyn Schmiedebergs Arch Pharmacol 371, no. 3 (March 2005): 229–39. https://doi.org/10.1007/s00210-005-1019-9.
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  - Stafford-Smith, Mark, Mihai Podgoreanu, Madhav Swaminathan, Barbara Phillips-Bute, Joseph P. Mathew, Elizabeth H. Hauser, Michelle P. Winn, et al. “Association of genetic polymorphisms with risk of renal injury after coronary bypass graft surgery.” Am J Kidney Dis 45, no. 3 (March 2005): 519–30. https://doi.org/10.1053/j.ajkd.2004.11.021.
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  - Welsby, Ian J., Mark F. Newman, Barbara Phillips-Bute, Robert H. Messier, Emil D. Kakkis, and Mark Stafford-Smith. “Hemodynamic changes after protamine administration: association with mortality after coronary artery bypass surgery.” Anesthesiology 102, no. 2 (February 2005): 308–14. https://doi.org/10.1097/00000542-200502000-00011.
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  - Conlon, Peter J., James Crowley, Richard Stack, John J. Neary, Mark Stafford-Smith, William D. White, Mark F. Newman, and Kevin Landolfo. “Renal artery stenosis is not associated with the development of acute renal failure following coronary artery bypass grafting.” Ren Fail 27, no. 1 (2005): 81–86.
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  - Corkey, William B., Barbara Phillips-Bute, Bruno Baudet, Joseph P. Mathew, Mark F. Newman, and Hilary P. Grocott. “Brief report: The declining incidence of cerebral hyperthermia during cardiac surgery: a seven-year experience in 6,334 patients.” Can J Anaesth 52, no. 6 (2005): 626–29. https://doi.org/10.1007/BF03015774.
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  - Newman, Mark F., James A. Blumenthal, and Daniel B. Mark. “Fixing the heart: must the brain pay the price?” Circulation 110, no. 22 (November 30, 2004): 3402–3. https://doi.org/10.1161/01.CIR.0000150860.91937.ED.
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  - Sreeram, Gautam M., Hilary P. Grocott, William D. White, Mark F. Newman, and Mark Stafford-Smith. “Transcranial Doppler emboli count predicts rise in creatinine after coronary artery bypass graft surgery.” J Cardiothorac Vasc Anesth 18, no. 5 (October 2004): 548–51. https://doi.org/10.1053/j.jvca.2004.07.010.
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  - Mathew, Joseph P., Stanton K. Shernan, William D. White, Jane C. K. Fitch, John C. Chen, Leonard Bell, and Mark F. Newman. “Preliminary report of the effects of complement suppression with pexelizumab on neurocognitive decline after coronary artery bypass graft surgery.” Stroke 35, no. 10 (October 2004): 2335–39. https://doi.org/10.1161/01.STR.0000141938.00524.83.
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  - Bar-Yosef, Shahar, Joseph P. Mathew, Mark F. Newman, Kevin P. Landolfo, Hilary P. Grocott, and Hilary P. Neurological Outcome Research Group and C.A.R.E. Investigators of the Duke Heart Center. “Prevention of cerebral hyperthermia during cardiac surgery by limiting on-bypass rewarming in combination with post-bypass body surface warming: a feasibility study.” Anesth Analg 99, no. 3 (September 2004): 641–46. https://doi.org/10.1213/01.ANE.0000130354.90659.63.
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  - McKinlay, Kenneth H., David B. Schinderle, Madhav Swaminathan, Mihai V. Podgoreanu, Carmelo A. Milano, Robert H. Messier, Habib El-Moalem, Mark F. Newman, Fiona M. Clements, and Joseph P. Mathew. “Predictors of inotrope use during separation from cardiopulmonary bypass.” J Cardiothorac Vasc Anesth 18, no. 4 (August 2004): 404–8. https://doi.org/10.1053/j.jvca.2004.05.015.
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  - Taekman, Jeffrey M., Gene Hobbs, Linda Barber, Barbara G. Phillips-Bute, Melanie C. Wright, Mark F. Newman, and Mark Stafford-Smith. “Preliminary report on the use of high-fidelity simulation in the training of study coordinators conducting a clinical research protocol.” Anesth Analg 99, no. 2 (August 2004): 521–27. https://doi.org/10.1213/01.ANE.0000132694.77191.BA.
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  - MacKensen, G Burkhard, Madhav Swaminathan, Lian K. Ti, Hilary P. Grocott, Barbara G. Phillips-Bute, Joseph P. Mathew, Mark F. Newman, et al. “Preliminary report on the interaction of apolipoprotein E polymorphism with aortic atherosclerosis and acute nephropathy after CABG.” Ann Thorac Surg 78, no. 2 (August 2004): 520–26. https://doi.org/10.1016/j.athoracsur.2004.02.106.
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  - Verrier, Edward D., Stanton K. Shernan, Kenneth M. Taylor, Frans Van de Werf, Mark F. Newman, John C. Chen, Michel Carrier, et al. “Terminal complement blockade with pexelizumab during coronary artery bypass graft surgery requiring cardiopulmonary bypass: a randomized trial.” Jama 291, no. 19 (May 19, 2004): 2319–27. https://doi.org/10.1001/jama.291.19.2319.
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  - Booth, John V., Erin E. Ward, Kelly C. Colgan, Bonita L. Funk, Habib El-Moalem, Michael P. Smith, Carmelo Milano, et al. “Metoprolol and coronary artery bypass grafting surgery: does intraoperative metoprolol attenuate acute beta-adrenergic receptor desensitization during cardiac surgery?” Anesth Analg 98, no. 5 (May 2004): 1224–31. https://doi.org/10.1213/01.ane.0000112325.66981.03.
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  - Galli, Kristin K., Robert A. Zimmerman, Gail P. Jarvik, Gil Wernovsky, Marijn K. Kuypers, Robert R. Clancy, Lisa M. Montenegro, et al. “Periventricular leukomalacia is common after neonatal cardiac surgery.” J Thorac Cardiovasc Surg 127, no. 3 (March 2004): 692–704. https://doi.org/10.1016/j.jtcvs.2003.09.053.
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  - Djaiani, George, Barbara Phillips-Bute, Mihai Podgoreanu, Robert H. Messier, Joseph P. Mathew, Fiona Clements, and Mark F. Newman. “The association of patent foramen ovale and atrial fibrillation after coronary artery bypass graft surgery.” Anesth Analg 98, no. 3 (March 2004): 585–89. https://doi.org/10.1213/01.ane.0000099721.67426.de.
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  - Kong, David F., Eric L. Eisenstein, Michael H. Sketch, James P. Zidar, Thomas J. Ryan, Robert A. Harrington, Mark F. Newman, Peter K. Smith, Daniel B. Mark, and Robert M. Califf. “Economic impact of drug-eluting stents on hospital systems: a disease-state model.” Am Heart J 147, no. 3 (March 2004): 449–56. https://doi.org/10.1016/j.ahj.2003.11.005.
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  - Grocott, Hilary P., Joseph P. Mathew, Elizabeth H. Carver, Barbara Phillips-Bute, Kevin P. Landolfo, Mark F. Newman, and Mark F. and the Neurologic Outcome Research Group (NORG) of the Duke Heart Center. “A randomized controlled trial of the Arctic Sun Temperature Management System versus conventional methods for preventing hypothermia during off-pump cardiac surgery.” Anesth Analg 98, no. 2 (February 2004): 298–302. https://doi.org/10.1213/01.ANE.0000096242.06561.C0.
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  - Lynch, John R., Robert Blessing, William D. White, Hilary P. Grocott, Mark F. Newman, and Daniel T. Laskowitz. “Novel diagnostic test for acute stroke.” Stroke 35, no. 1 (January 2004): 57–63. https://doi.org/10.1161/01.STR.0000105927.62344.4C.
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  - Lett, Heather S., James A. Blumenthal, Michael A. Babyak, Andrew Sherwood, Timothy Strauman, Clive Robins, and Mark F. Newman. “Depression as a risk factor for coronary artery disease: evidence, mechanisms, and treatment.” Psychosom Med 66, no. 3 (2004): 305–15. https://doi.org/10.1097/01.psy.0000126207.43307.c0.
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  - Kilts, Jason D., Toshimasa Akazawa, Habib E. El-Moalem, Joseph P. Mathew, Mark F. Newman, and Madan M. Kwatra. “Age increases expression and receptor-mediated activation of G alpha i in human atria.” J Cardiovasc Pharmacol 42, no. 5 (November 2003): 662–70. https://doi.org/10.1097/00005344-200311000-00013.
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  - Lucas, Sebastian. “Depression as risk factor for mortality after coronary artery bypass surgery.” Lancet 362, no. 9394 (November 1, 2003): 1499–1500. https://doi.org/10.1016/S0140-6736(03)14701-0.
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  - Ghanayem, N. S., G. M. Hoffman, K. A. Mussatto, J. R. Cava, P. C. Frommelt, N. A. Rudd, M. M. Steltzer, et al. “Home surveillance program prevents interstage mortality after the Norwood procedure.” J Thorac Cardiovasc Surg 126, no. 5 (November 2003): 1367–77. https://doi.org/10.1016/s0022-5223(03)00071-0.
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  - Swaminathan, Madhav, Barbara G. Phillips-Bute, Peter J. Conlon, Peter K. Smith, Mark F. Newman, and Mark Stafford-Smith. “The association of lowest hematocrit during cardiopulmonary bypass with acute renal injury after coronary artery bypass surgery.” Ann Thorac Surg 76, no. 3 (September 2003): 784–91. https://doi.org/10.1016/s0003-4975(03)00558-7.
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  - Blumenthal, James A., Heather S. Lett, Michael A. Babyak, William White, Peter K. Smith, Daniel B. Mark, Robert Jones, Joseph P. Mathew, Mark F. Newman, and Mark F. NORG Investigators. “Depression as a risk factor for mortality after coronary artery bypass surgery.” Lancet 362, no. 9384 (August 23, 2003): 604–9. https://doi.org/10.1016/S0140-6736(03)14190-6.
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  - Booth, John V., Barbara Phillips-Bute, Charles B. McCants, Mihai V. Podgoreanu, Peter K. Smith, Joseph P. Mathew, and Mark F. Newman. “Low serum magnesium level predicts major adverse cardiac events after coronary artery bypass graft surgery.” Am Heart J 145, no. 6 (June 2003): 1108–13. https://doi.org/10.1016/S0002-8703(03)00077-2.
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  - Djaiani, George N., Barbara Phillips-Bute, James A. Blumenthal, Mark F. Newman, Mark F. Neurologic Outcome Research Group, and Mark F. CARE Investigators of the Duke Heart Center. “Chronic exposure to nicotine does not prevent neurocognitive decline after cardiac surgery.” J Cardiothorac Vasc Anesth 17, no. 3 (June 2003): 341–45. https://doi.org/10.1016/s1053-0770(03)00047-8.
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  - Stanley, Timothy O., Hilary P. Grocott, Barbara Phillips-Bute, Joseph P. Mathew, Kevin P. Landolfo, Mark F. Newman, Mark F. Neurologic Outcome Research Group C.A.R.E, and Mark F. Investigators of the Duke Heart Center. “Preliminary evaluation of the Arctic Sun temperature-controlling system during off-pump coronary artery bypass surgery.” Ann Thorac Surg 75, no. 4 (April 2003): 1140–44. https://doi.org/10.1016/s0003-4975(02)04545-9.
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  - Albahrani, Maher J., Madhav Swaminathan, Barbara Phillips-Bute, Peter K. Smith, Mark F. Newman, Joseph P. Mathew, and Mark Stafford-Smith. “Postcardiac surgery complications: association of acute renal dysfunction and atrial fibrillation.” Anesth Analg 96, no. 3 (March 2003): 637–43. https://doi.org/10.1213/01.ANE.0000047886.81598.2C.
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  - Hagen, Scott A., Amy L. Kondyra, Hilary P. Grocott, Habib El-Moalem, Daniel Bainbridge, Joseph P. Mathew, Mark F. Newman, Joseph G. Reves, Debra A. Schwinn, and Madan M. Kwatra. “Cardiopulmonary bypass decreases G protein-coupled receptor kinase activity and expression in human peripheral blood mononuclear cells.” Anesthesiology 98, no. 2 (February 2003): 343–48. https://doi.org/10.1097/00000542-200302000-00012.
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  - Mathew, Joseph P., Hilary P. Grocott, Barbara Phillips-Bute, Mark Stafford-Smith, Daniel T. Laskowitz, Daniel Rossignol, James A. Blumenthal, Mark F. Newman, Mark F. Neurologic Outcome Research Group of the Duke Heart Center, and Mark F. Cardiothoracic Anesthesiology Research Endeavors Investigators of the Duke Heart Center. “Lower endotoxin immunity predicts increased cognitive dysfunction in elderly patients after cardiac surgery.” Stroke 34, no. 2 (February 2003): 508–13. https://doi.org/10.1161/01.str.0000053844.09493.58.
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  - Ti, Lian K., G Burkhard Mackensen, Hilary P. Grocott, Daniel T. Laskowitz, Barbara G. Phillips-Bute, Carmelo A. Milano, Andrew K. Hilton, Mark F. Newman, Joseph P. Mathew, and Joseph P. Neurologic Outcome Research Group. “Apolipoprotein E4 increases aortic atheroma burden in cardiac surgical patients.” J Thorac Cardiovasc Surg 125, no. 1 (January 2003): 211–13. https://doi.org/10.1067/mtc.2003.123.
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  - Phillips Bute, Barbara, Joseph Mathew, James A. Blumenthal, Kathleen Welsh-Bohmer, William D. White, Daniel Mark, Kevin Landolfo, and Mark F. Newman. “Female gender is associated with impaired quality of life 1 year after coronary artery bypass surgery.” Psychosom Med 65, no. 6 (2003): 944–51. https://doi.org/10.1097/01.psy.0000097342.24933.a2.
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  - Scarborough, John E., William White, Frantz E. Derilus, Joseph P. Mathew, Mark F. Newman, and Kevin P. Landolfo. “Neurologic outcomes after coronary artery bypass grafting with and without cardiopulmonary bypass.” Semin Thorac Cardiovasc Surg 15, no. 1 (January 2003): 52–62. https://doi.org/10.1016/s1043-0679(03)70042-2.
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  - Hill, Steven E., Bruce J. Leone, N Simon Faithfull, Kathy E. Flaim, Peter E. Keipert, and Mark F. Newman. “Perflubron emulsion (AF0144) augments harvesting of autologous blood: a phase II study in cardiac surgery.” J Cardiothorac Vasc Anesth 16, no. 5 (October 2002): 555–60. https://doi.org/10.1053/jcan.2002.126947.
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  - Reynolds, James D., David W. Amory, Hilary P. Grocott, William D. White, and Mark F. Newman. “Change in plasma glutamate concentration during cardiac surgery is a poor predictor of cognitive outcome.” J Cardiothorac Vasc Anesth 16, no. 4 (August 2002): 431–36. https://doi.org/10.1053/jcan.2002.125148.
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  - O’Connor, Christopher M., Eric J. Velazquez, Laura H. Gardner, Peter K. Smith, Mark F. Newman, Kevin P. Landolfo, Kerry L. Lee, Robert M. Califf, and Robert H. Jones. “Comparison of coronary artery bypass grafting versus medical therapy on long-term outcome in patients with ischemic cardiomyopathy (a 25-year experience from the Duke Cardiovascular Disease Databank).” Am J Cardiol 90, no. 2 (July 15, 2002): 101–7. https://doi.org/10.1016/s0002-9149(02)02429-3.
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  - Amory, David W., Alina Grigore, John K. Amory, Mark A. Gerhardt, William D. White, Peter K. Smith, Debra A. Schwinn, J. G. Reves, and Mark F. Newman. “Neuroprotection is associated with beta-adrenergic receptor antagonists during cardiac surgery: evidence from 2,575 patients.” J Cardiothorac Vasc Anesth 16, no. 3 (June 2002): 270–77. https://doi.org/10.1053/jcan.2002.124132.
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  - Sato, Yukie, Daniel T. Laskowitz, Ellen R. Bennett, Mark F. Newman, David S. Warner, and Hilary P. Grocott. “Differential cerebral gene expression during cardiopulmonary bypass in the rat: evidence for apoptosis?” Anesth Analg 94, no. 6 (June 2002): 1389–94. https://doi.org/10.1097/00000539-200206000-00003.
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  - Murkin, John. “Best evidence in anesthetic practice. Prognosis: cognitive function at hospital discharge predicts long-term cognitive function after coronary artery bypass surgery.” Can J Anaesth 49, no. 5 (May 2002): 497–98. https://doi.org/10.1007/BF03017929.
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  - Welsby, Ian J., Elliott Bennett-Guerrero, Darryl Atwell, William D. White, Mark F. Newman, Peter K. Smith, and Michael G. Mythen. “The association of complication type with mortality and prolonged stay after cardiac surgery with cardiopulmonary bypass.” Anesth Analg 94, no. 5 (May 2002): 1072–78. https://doi.org/10.1097/00000539-200205000-00004.
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  - Mark, Daniel B., and Mark F. Newman. “Protecting the brain in coronary artery bypass graft surgery.” Jama 287, no. 11 (March 20, 2002): 1448–50. https://doi.org/10.1001/jama.287.11.1448.
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  - Grocott, Hilary P., G Burkhard Mackensen, Alina M. Grigore, Joseph Mathew, J. G. Reves, Barbara Phillips-Bute, Peter K. Smith, Mark F. Newman, Mark F. Neurologic Outcome Research Group (NORG), and Mark F. Cardiothoracic Anesthesiology Research Endeavors (CARE) Investigators’ of the Duke Heart Center. “Postoperative hyperthermia is associated with cognitive dysfunction after coronary artery bypass graft surgery.” Stroke 33, no. 2 (February 2002): 537–41. https://doi.org/10.1161/hs0202.102600.
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  - Stanley, Timothy O., G Burkhard Mackensen, Hilary P. Grocott, William D. White, James A. Blumenthal, Daniel T. Laskowitz, Kevin P. Landolfo, et al. “The impact of postoperative atrial fibrillation on neurocognitive outcome after coronary artery bypass graft surgery.” Anesth Analg 94, no. 2 (February 2002): 290–95. https://doi.org/10.1097/00000539-200202000-00011.
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  - Sharma, Ajeet D., Thomas F. Slaughter, Fiona M. Clements, Gautam Sreeram, Mark F. Newman, Barbara Phillips-Bute, Steven J. Bredehoeft, Peter K. Smith, and Mark Stafford-Smith. “Association of leukocyte-depleted blood transfusions with infectious complications after cardiac surgery.” Surg Infect (Larchmt) 3, no. 2 (2002): 127–33. https://doi.org/10.1089/109629602760105790.
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  - Mackensen, G. B., Y. Sato, B. Nellgård, J. Pineda, M. F. Newman, D. S. Warner, and H. P. Grocott. “Cardiopulmonary bypass induces neurologic and neurocognitive dysfunction in the rat.” Anesthesiology 95, no. 6 (December 2001): 1485–91. https://doi.org/10.1097/00000542-200112000-00031.
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  - Newman, M. F., H. P. Grocott, J. P. Mathew, W. D. White, K. Landolfo, J. G. Reves, D. T. Laskowitz, D. B. Mark, J. A. Blumenthal, and J. A. Neurologic Outcome Research Group and the Cardiothoracic Anesthesia Research Endeavors (CARE) Investigators of the Duke Heart Center. “Report of the substudy assessing the impact of neurocognitive function on quality of life 5 years after cardiac surgery.” Stroke 32, no. 12 (December 1, 2001): 2874–81. https://doi.org/10.1161/hs1201.099803.
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  - Ti, L. K., J. P. Mathew, G. B. Mackensen, H. P. Grocott, A. M. Saunders, W. D. White, J. G. Reves, and M. F. Newman. “Erratum: Effect of apolipoprotein E genotype on cerebral autoregulation during cardiopulmonary bypass (Store (July 2000) 32:7 (1514-1519)).” Stroke 32, no. 11 (November 24, 2001): 2727.
  - Grigore, A. M., J. Mathew, H. P. Grocott, J. G. Reves, J. A. Blumenthal, W. D. White, P. K. Smith, et al. “Prospective randomized trial of normothermic versus hypothermic cardiopulmonary bypass on cognitive function after coronary artery bypass graft surgery.” Anesthesiology 95, no. 5 (November 2001): 1110–19. https://doi.org/10.1097/00000542-200111000-00014.
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  - Swaminathan, M., C. East, B. Phillips-Bute, M. F. Newman, J. G. Reves, P. K. Smith, and M. Stafford-Smith. “Report of a substudy on warm versus cold cardiopulmonary bypass: changes in creatinine clearance.” Ann Thorac Surg 72, no. 5 (November 2001): 1603–9. https://doi.org/10.1016/s0003-4975(01)03223-4.
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  - Bainbridge, D. T., G. B. Mackensen, M. F. Newman, K. P. Landolfo, and H. P. Grocott. “Off-pump coronary artery bypass surgery in a patient with C1 esterase inhibitor deficiency.” Anesthesiology 95, no. 3 (September 2001): 795–96. https://doi.org/10.1097/00000542-200109000-00037.
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  - Grocott, H. P., M. F. Newman, H. El-Moalem, D. Bainbridge, A. Butler, and D. T. Laskowitz. “Apolipoprotein E genotype differentially influences the proinflammatory and anti-inflammatory response to cardiopulmonary bypass.” J Thorac Cardiovasc Surg 122, no. 3 (September 2001): 622–23. https://doi.org/10.1067/mtc.2001.115152.
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  - Aklog, L. “Neurocognitive function after coronary-artery bypass surgery.” N Engl J Med 345, no. 7 (August 16, 2001): 543–44. https://doi.org/10.1056/NEJM200108163450712.
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  - Ti, L. K., J. P. Mathew, G. B. Mackensen, H. P. Grocott, W. D. White, J. G. Reves, and M. F. Newman. “Effect of apolipoprotein E genotype on cerebral autoregulation during cardiopulmonary bypass.” Stroke 32, no. 7 (July 2001): 1514–19. https://doi.org/10.1161/01.str.32.7.1514.
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  - Cheng, D. C., M. F. Newman, P. Duke, D. T. Wong, B. Finegan, M. Howie, J. Fitch, et al. “The efficacy and resource utilization of remifentanil and fentanyl in fast-track coronary artery bypass graft surgery: a prospective randomized, double-blinded controlled, multi-center trial.” Anesth Analg 92, no. 5 (May 2001): 1094–1102. https://doi.org/10.1097/00000539-200105000-00004.
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  - Howie, M. B., D. Cheng, M. F. Newman, E. T. Pierce, C. Hogue, Z. Hillel, T. A. Bowdle, and D. Bukenya. “A randomized double-blinded multicenter comparison of remifentanil versus fentanyl when combined with isoflurane/propofol for early extubation in coronary artery bypass graft surgery.” Anesth Analg 92, no. 5 (May 2001): 1084–93. https://doi.org/10.1097/00000539-200105000-00003.
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  - Newman, M. F., D. T. Laskowitz, W. D. White, J. L. Kirchner, H. P. Grocott, M. Stafford-Smith, M. H. Sketch, R. H. Jones, J. G. Reves, and A. M. Saunders. “Apolipoprotein E polymorphisms and age at first coronary artery bypass graft.” Anesth Analg 92, no. 4 (April 2001): 824–29. https://doi.org/10.1097/00000539-200104000-00006.
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  - Newman, M. F. “Troponin I in cardiac surgery: marking the future.” Am Heart J 141, no. 3 (March 2001): 325–26. https://doi.org/10.1067/mhj.2001.113072.
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  - Newman, M. F., J. L. Kirchner, B. Phillips-Bute, V. Gaver, H. Grocott, R. H. Jones, D. B. Mark, J. G. Reves, J. A. Blumenthal, and J. A. Neurological Outcome Research Group and the Cardiothoracic Anesthesiology Research Endeavors Investigators. “Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery.” N Engl J Med 344, no. 6 (February 8, 2001): 395–402. https://doi.org/10.1056/NEJM200102083440601.
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  - Mathew, J. P., C. S. Rinder, J. G. Howe, M. Fontes, J. Crouch, M. F. Newman, B. Phillips-Bute, and B. R. Smith. “Platelet PlA2 polymorphism enhances risk of neurocognitive decline after cardiopulmonary bypass. Multicenter Study of Perioperative Ischemia (McSPI) Research Group.” Ann Thorac Surg 71, no. 2 (February 2001): 663–66. https://doi.org/10.1016/s0003-4975(00)02335-3.
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  - Grocott, H. P., G. B. Mackensen, M. F. Newman, and D. S. Warner. “Neurological injury during cardiopulmonary bypass in the rat.” Perfusion 16, no. 1 (January 2001): 75–81. https://doi.org/10.1177/026765910101600111.
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  - Khatri, P., M. Babyak, N. D. Croughwell, R. Davis, W. D. White, M. F. Newman, J. G. Reves, D. B. Mark, and J. A. Blumenthal. “Temperature during coronary artery bypass surgery affects quality of life.” Ann Thorac Surg 71, no. 1 (January 2001): 110–16. https://doi.org/10.1016/s0003-4975(00)02350-x.
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  - Newman, M. F., J. V. Booth, D. T. Laskowitz, D. A. Schwinn, H. P. Grocott, and J. P. Mathew. “Genetic predictors of perioperative neurological and cognitive injury and recovery.” Best Practice and Research: Clinical Anaesthesiology 15, no. 2 (January 1, 2001): 247–76. https://doi.org/10.1053/bean.2001.0155.
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  - Grigore, A. M., H. P. Grocott, and M. F. Newman. “Anesthetic management of a patient with a brain tumor for cardiac surgery.” J Cardiothorac Vasc Anesth 14, no. 6 (December 2000): 702–4. https://doi.org/10.1053/jcan.2000.18442.
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  - Gamoso, M. G., B. Phillips-Bute, K. P. Landolfo, M. F. Newman, and M. Stafford-Smith. “Off-pump versus on-pump coronary artery bypass surgery and postoperative renal dysfunction.” Anesth Analg 91, no. 5 (November 2000): 1080–84. https://doi.org/10.1097/00000539-200011000-00007.
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  - Stafford-Smith, M., B. Phillips-Bute, D. N. Reddan, J. Black, and M. F. Newman. “The association of epsilon-aminocaproic acid with postoperative decrease in creatinine clearance in 1502 coronary bypass patients.” Anesth Analg 91, no. 5 (November 2000): 1085–90. https://doi.org/10.1097/00000539-200011000-00008.
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  - Kilts, J. D., M. A. Gerhardt, M. D. Richardson, G. Sreeram, G. B. Mackensen, H. P. Grocott, W. D. White, et al. “Beta(2)-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i).” Circ Res 87, no. 8 (October 13, 2000): 705–9. https://doi.org/10.1161/01.res.87.8.705.
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  - Chew, S. T., M. F. Newman, W. D. White, P. J. Conlon, A. M. Saunders, W. J. Strittmatter, K. Landolfo, H. P. Grocott, and M. Stafford-Smith. “Preliminary report on the association of apolipoprotein E polymorphisms, with postoperative peak serum creatinine concentrations in cardiac surgical patients.” Anesthesiology 93, no. 2 (August 2000): 325–31. https://doi.org/10.1097/00000542-200008000-00008.
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  - Hill, S. E., G. K. van Wermeskerken, J. W. Lardenoye, B. Phillips-Bute, P. K. Smith, J. G. Reves, and M. F. Newman. “Intraoperative physiologic variables and outcome in cardiac surgery: Part I. In-hospital mortality.” Ann Thorac Surg 69, no. 4 (April 2000): 1070–75. https://doi.org/10.1016/s0003-4975(99)01442-3.
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  - Wermeskerken, G. K. van, J. W. Lardenoye, S. E. Hill, H. P. Grocott, B. Phillips-Bute, P. K. Smith, J. G. Reves, and M. F. Newman. “Intraoperative physiologic variables and outcome in cardiac surgery: Part II. Neurologic outcome.” Ann Thorac Surg 69, no. 4 (April 2000): 1077–83. https://doi.org/10.1016/s0003-4975(99)01443-5.
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  - Arrowsmith, J. E., H. P. Grocott, J. G. Reves, and M. F. Newman. “Central nervous system complications of cardiac surgery.” Br J Anaesth 84, no. 3 (March 2000): 378–93. https://doi.org/10.1093/oxfordjournals.bja.a013444.
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  - Arrowsmith, J. E., H. P. Grocott, J. G. Reves, M. F. Newman, and F. Levy. “Central nervous system complications of cardiac surgery.” Cahiers D’Anesthesiologie 48, no. 3 (January 1, 2000): 233–40.
  - Kilts, J. D., M. A. Gerhardt, M. D. Richardson, G. Sreeram, G. B. Mackensen, H. P. Grocott, W. D. White, et al. “β₂-Adrenergic and several other g protein-coupled receptors in human atrial membranes activate both G(s) and G(i).” Circulation Research 87, no. 8 (2000): 705–9.
  - Newman, M. F., T. O. Stanley, and H. P. Grocott. “Strategies to protect the brain during cardiac surgery.” Seminars in Cardiothoracic and Vascular Anesthesia 4, no. 2 (January 1, 2000): 53–64. https://doi.org/10.1053/vc.2000.6499.
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  - Arrowsmith, J. E., H. P. Grocott, and M. F. Newman. “Neurologic risk assessment, monitoring and outcome in cardiac surgery.” J Cardiothorac Vasc Anesth 13, no. 6 (December 1999): 736–43. https://doi.org/10.1016/s1053-0770(99)90132-5.
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  - Glower, D. D., J. Komtebedde, F. M. Clements, N. P. Debruijn, M. Stafford-Smith, and M. F. Newman. “Direct aortic cannulation for port-access mitral or coronary artery bypass grafting.” Ann Thorac Surg 68, no. 5 (November 1999): 1878–80. https://doi.org/10.1016/s0003-4975(99)01011-5.
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  - Grichnik, K. P., A. J. Ijsselmuiden, T. A. D’Amico, D. H. Harpole, W. D. White, J. A. Blumenthal, and M. F. Newman. “Cognitive decline after major noncardiac operations: a preliminary prospective study.” Ann Thorac Surg 68, no. 5 (November 1999): 1786–91. https://doi.org/10.1016/s0003-4975(99)00992-3.
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  - Bennett-Guerrero, E., I. Welsby, T. J. Dunn, L. R. Young, T. A. Wahl, T. L. Diers, B. G. Phillips-Bute, M. F. Newman, and M. G. Mythen. “The use of a postoperative morbidity survey to evaluate patients with prolonged hospitalization after routine, moderate-risk, elective surgery.” Anesth Analg 89, no. 2 (August 1999): 514–19. https://doi.org/10.1097/00000539-199908000-00050.
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  - Bennett-Guerrero, E., W. F. Spillane, W. D. White, L. H. Muhlbaier, S. A. Gall, P. K. Smith, and M. F. Newman. “Epsilon-aminocaproic acid administration and stroke following coronary artery bypass graft surgery.” Ann Thorac Surg 67, no. 5 (May 1999): 1283–87. https://doi.org/10.1016/s0003-4975(99)00116-2.
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  - Khatri, P., M. Babyak, C. Clancy, R. Davis, N. Croughwell, M. Newman, J. G. Reves, D. B. Mark, and J. A. Blumenthal. “Perception of cognitive function in older adults following coronary artery bypass surgery.” Health Psychol 18, no. 3 (May 1999): 301–6. https://doi.org/10.1037//0278-6133.18.3.301.
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  - Roach, G. W., M. F. Newman, J. M. Murkin, J. Martzke, A. Ruskin, J. Li, A. Guo, A. Wisniewski, and D. T. Mangano. “Ineffectiveness of burst suppression therapy in mitigating perioperative cerebrovascular dysfunction. Multicenter Study of Perioperative Ischemia (McSPI) Research Group.” Anesthesiology 90, no. 5 (May 1999): 1255–64. https://doi.org/10.1097/00000542-199905000-00006.
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  - Conlon, P. J., M. Stafford-Smith, W. D. White, M. F. Newman, S. King, M. P. Winn, and K. Landolfo. “Acute renal failure following cardiac surgery.” Nephrol Dial Transplant 14, no. 5 (May 1999): 1158–62. https://doi.org/10.1093/ndt/14.5.1158.
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  - Wolman, R. L., N. A. Nussmeier, A. Aggarwal, M. S. Kanchuger, G. W. Roach, M. F. Newman, C. M. Mangano, et al. “Cerebral injury after cardiac surgery: identification of a group at extraordinary risk. Multicenter Study of Perioperative Ischemia Research Group (McSPI) and the Ischemia Research Education Foundation (IREF) Investigators.” Stroke 30, no. 3 (March 1999): 514–22. https://doi.org/10.1161/01.str.30.3.514.
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  - Newman, M. F., D. T. Laskowitz, A. M. Saunders, A. M. Grigore, and H. P. Grocott. “Genetic predictors of perioperative neurologic and neuropsychological injury and recovery.” Seminars in Cardiothoracic and Vascular Anesthesia 3, no. 1 (January 1, 1999): 34–46. https://doi.org/10.1177/108925329900300107.
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  - Grocott, H. P., and M. F. Newman. “Temperature measurement during cardiac surgery.” Can J Anaesth 45, no. 11 (November 1998): 1133–34. https://doi.org/10.1007/BF03012410.
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  - Atwell, D. M., K. P. Grichnik, M. F. Newman, J. G. Reves, and W. T. McBride. “Balance of proinflammatory and antiinflammatory cytokines at thoracic cancer operation.” Ann Thorac Surg 66, no. 4 (October 1998): 1145–50. https://doi.org/10.1016/s0003-4975(98)00592-x.
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  - Weiss, L., H. P. Grocott, R. A. Rosania, A. Friedman, M. F. Newman, and D. S. Warner. “Case 4--1998. Cardiopulmonary bypass and hypothermic circulatory arrest for basilar artery aneurysm clipping.” J Cardiothorac Vasc Anesth 12, no. 4 (August 1998): 473–79. https://doi.org/10.1016/s1053-0770(98)90206-3.
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  - Grocott, H. P., N. D. Croughwell, D. W. Amory, W. D. White, J. L. Kirchner, and M. F. Newman. “Cerebral emboli and serum S100beta during cardiac operations.” Ann Thorac Surg 65, no. 6 (June 1998): 1645–49. https://doi.org/10.1016/s0003-4975(98)00276-8.
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  - Croughwell, N. D., J. G. Reves, W. D. White, H. P. Grocott, B. I. Baldwin, F. M. Clements, R. D. Davis, R. H. Jones, and M. F. Newman. “Cardiopulmonary bypass time does not affect cerebral blood flow.” Ann Thorac Surg 65, no. 5 (May 1998): 1226–30. https://doi.org/10.1016/s0003-4975(98)00113-1.
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  - Newman, M. F., N. D. Croughwell, W. D. White, I. Sanderson, W. Spillane, and J. G. Reves. “Pharmacologic electroencephalographic suppression during cardiopulmonary bypass: a comparison of thiopental and isoflurane.” Anesth Analg 86, no. 2 (February 1998): 246–51. https://doi.org/10.1097/00000539-199802000-00005.
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  - Grocott, H. P., D. W. Amory, E. Lowry, N. D. Croughwell, and M. F. Newman. “Transcranial Doppler blood flow velocity versus 133Xe clearance cerebral blood flow during mild hypothermic cardiopulmonary bypass.” J Clin Monit Comput 14, no. 1 (January 1998): 35–39. https://doi.org/10.1023/a:1007493422230.
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  - Bennett-Guerrero, E., J. G. Sorohan, M. L. Gurevich, P. E. Kazanjian, R. R. Levy, A. V. Barberá, W. D. White, et al. “Cost-benefit and efficacy of aprotinin compared with epsilon-aminocaproic acid in patients having repeated cardiac operations: a randomized, blinded clinical trial.” Anesthesiology 87, no. 6 (December 1997): 1373–80. https://doi.org/10.1097/00000542-199712000-00017.
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  - Hlatky, M. A., C. Bacon, D. Boothroyd, E. Mahanna, J. G. Reves, M. F. Newman, I. Johnstone, et al. “Cognitive function 5 years after randomization to coronary angioplasty or coronary artery bypass graft surgery.” Circulation 96, no. 9 Suppl (November 4, 1997): II-11–14.
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  - Grocott, H. P., D. W. Amory, E. Lowry, M. F. Newman, J. E. Lowe, and F. M. Clements. “Cerebral embolization during transmyocardial laser revascularization.” J Thorac Cardiovasc Surg 114, no. 5 (November 1997): 856–58. https://doi.org/10.1016/S0022-5223(97)70095-3.
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  - Grichnik, K. P., M. F. Newman, and J. G. Reves. “The aging central nervous system.” Problems in Anesthesia 9, no. 4 (October 1, 1997): 513–24.
  - Newman, M. F., and J. G. Reves. “Feeling the heat.” J Cardiothorac Vasc Anesth 11, no. 6 (October 1997): 687–88. https://doi.org/10.1016/s1053-0770(97)90157-9.
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  - Reves, J. G., R. N. Sladen, and M. F. Newman. “CACI in cardiac surgery.” Anesthesiology 87, no. 4 (October 1997): 1015. https://doi.org/10.1097/00000542-199710000-00055.
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  - Bennett-Guerrero, E., J. G. Sorohan, A. T. Canada, L. Ayuso, M. F. Newman, J. G. Reves, and M. G. Mythen. “epsilon-Aminocaproic acid plasma levels during cardiopulmonary bypass.” Anesth Analg 85, no. 2 (August 1997): 248–51. https://doi.org/10.1097/00000539-199708000-00002.
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  - Grocott, H. P., M. F. Newman, N. D. Croughwell, W. D. White, E. Lowry, and J. G. Reves. “Continuous jugular venous versus nasopharyngeal temperature monitoring during hypothermic cardiopulmonary bypass for cardiac surgery.” J Clin Anesth 9, no. 4 (June 1997): 312–16. https://doi.org/10.1016/s0952-8180(97)00009-3.
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  - Grocott, H. P., M. F. Newman, J. E. Lowe, and F. Clements. “Transmyocardial laser revascularization: an anesthetic perspective.” J Cardiothorac Vasc Anesth 11, no. 2 (April 1997): 206–10. https://doi.org/10.1016/s1053-0770(97)90218-4.
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  - Bennett-Guerrero, E., L. Ayuso, C. Hamilton-Davies, W. D. White, G. R. Barclay, P. K. Smith, S. A. King, L. H. Muhlbaier, M. F. Newman, and M. G. Mythen. “Relationship of preoperative antiendotoxin core antibodies and adverse outcomes following cardiac surgery.” Jama 277, no. 8 (February 26, 1997): 646–50.
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  - Newman, M. F., and J. G. Reves. “Toward a new frontier in cardiac surgery.” Ann Thorac Surg 63, no. 2 (February 1997): 322–23. https://doi.org/10.1016/s0003-4975(96)01224-6.
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  - Croughwell, N. D., M. F. Newman, E. Lowry, R. D. Davis, K. P. Landolfo, W. D. White, J. L. Kirchner, and M. G. Mythen. “Effect of temperature during cardiopulmonary bypass on gastric mucosal perfusion.” Br J Anaesth 78, no. 1 (January 1997): 34–38. https://doi.org/10.1093/bja/78.1.34.
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  - Reves, J. G., R. N. Sladen, M. F. Newman, and U. Jain. “CACl in cardiac surgery [8] (multiple letters).” Anesthesiology 87, no. 4 (January 1, 1997): 1015.
  - Roach, G. W., M. Kanchuger, C. M. Mangano, M. Newman, N. Nussmeier, R. Wolman, A. Aggarwal, K. Marschall, S. H. Graham, and C. Ley. “Adverse cerebral outcomes after coronary bypass surgery. Multicenter Study of Perioperative Ischemia Research Group and the Ischemia Research and Education Foundation Investigators.” N Engl J Med 335, no. 25 (December 19, 1996): 1857–63. https://doi.org/10.1056/NEJM199612193352501.
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  - Bennett-Guerrero, E., J. G. Sorohan, S. T. Howell, L. Ayuso, R. A. Cardigan, M. F. Newman, I. J. Mackie, J. G. Reves, and M. G. Mythen. “Maintenance of therapeutic plasma aprotinin levels during prolonged cardiopulmonary bypass using a large-dose regimen.” Anesth Analg 83, no. 6 (December 1996): 1189–92. https://doi.org/10.1097/00000539-199612000-00010.
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  - Newman, M. F., N. D. Croughwell, W. D. White, E. Lowry, B. I. Baldwin, F. M. Clements, R. D. Davis, R. H. Jones, D. W. Amory, and J. G. Reves. “Effect of perfusion pressure on cerebral blood flow during normothermic cardiopulmonary bypass.” Circulation 94, no. 9 Suppl (November 1, 1996): II353–57.
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  - Newman, M. F., N. D. Croughwell, W. D. White, E. Lowry, B. I. Baldwin, F. M. Clements, R. D. Davis, R. H. Jones, D. W. Amory, and J. G. Reves. “Effect of perfusion pressure on cerebral blood flow during normothermic cardiopulmonary bypass.” Circulation 94, no. 9 SUPPL. (November 1, 1996).
  - Newman, M. F., R. Wolman, M. Kanchuger, K. Marschall, C. Mora-Mangano, G. Roach, L. R. Smith, et al. “Multicenter preoperative stroke risk index for patients undergoing coronary artery bypass graft surgery. Multicenter Study of Perioperative Ischemia (McSPI) Research Group.” Circulation 94, no. 9 Suppl (November 1, 1996): II74–80.
    Link to Item
  - Newman, M. F., R. Wolman, M. Kanchuger, K. Marschall, C. Mora-Mangano, G. Roach, L. R. Smith, et al. “Multicenter preoperative stroke risk index for patients undergoing coronary artery bypass graft surgery.” Circulation 94, no. 9 SUPPL. (November 1, 1996).
  - Newman, M. F., N. D. Croughwell, J. A. Blumenthal, E. Lowry, W. D. White, and J. G. Reves. “Cardiopulmonary bypass and the central nervous system: potential for cerebral protection.” J Clin Anesth 8, no. 3 Suppl (May 1996): 53S-60S. https://doi.org/10.1016/s0952-8180(96)90013-6.
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  - Jones, R. H., K. Kesler, H. R. Phillips, D. B. Mark, P. K. Smith, C. L. Nelson, M. F. Newman, J. G. Reves, R. W. Anderson, and R. M. Califf. “Long-term survival benefits of coronary artery bypass grafting and percutaneous transluminal angioplasty in patients with coronary artery disease.” J Thorac Cardiovasc Surg 111, no. 5 (May 1996): 1013–25. https://doi.org/10.1016/s0022-5223(96)70378-1.
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  - Mahanna, E. P., J. A. Blumenthal, W. D. White, N. D. Croughwell, C. P. Clancy, L. R. Smith, and M. F. Newman. “Defining neuropsychological dysfunction after coronary artery bypass grafting.” Ann Thorac Surg 61, no. 5 (May 1996): 1342–47. https://doi.org/10.1016/0003-4975(95)01095-5.
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  - Kern, F. H., R. M. Ungerleider, S. R. Schulman, J. N. Meliones, R. M. Schell, B. Baldwin, P. R. Hickey, M. F. Newman, R. A. Jonas, and W. J. Greeley. “Comparing two strategies of cardiopulmonary bypass cooling on jugular venous oxygen saturation in neonates and infants.” Ann Thorac Surg 60, no. 5 (November 1995): 1198–1202. https://doi.org/10.1016/0003-4975(95)00700-U.
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  - Reves, J. G., R. N. Sladen, and M. F. Newman. “Cardiac anesthetic: is it unique?” Anesth Analg 81, no. 5 (November 1995): 895–96. https://doi.org/10.1097/00000539-199511000-00001.
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  - Newman, M. F., J. M. Murkin, G. Roach, N. D. Croughwell, W. D. White, F. M. Clements, and J. G. Reves. “Cerebral physiologic effects of burst suppression doses of propofol during nonpulsatile cardiopulmonary bypass. CNS Subgroup of McSPI.” Anesth Analg 81, no. 3 (September 1995): 452–57. https://doi.org/10.1097/00000539-199509000-00004.
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  - Newman, M. F., D. Kramer, N. D. Croughwell, I. Sanderson, J. A. Blumenthal, W. D. White, L. R. Smith, E. A. Towner, and J. G. Reves. “Differential age effects of mean arterial pressure and rewarming on cognitive dysfunction after cardiac surgery.” Anesth Analg 81, no. 2 (August 1995): 236–42. https://doi.org/10.1097/00000539-199508000-00005.
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  - Croughwell, N. D., W. D. White, L. R. Smith, R. D. Davis, D. D. Glower, J. G. Reves, and M. F. Newman. “Jugular bulb saturation and mixed venous saturation during cardiopulmonary bypass.” J Card Surg 10, no. 4 Suppl (July 1995): 503–8. https://doi.org/10.1111/j.1540-8191.1995.tb00685.x.
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  - Blumenthal, J. A., E. P. Mahanna, D. J. Madden, W. D. White, N. D. Croughwell, and M. F. Newman. “Methodological issues in the assessment of neuropsychologic function after cardiac surgery.” Ann Thorac Surg 59, no. 5 (May 1995): 1345–50. https://doi.org/10.1016/0003-4975(95)00055-p.
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  - Newman, M. F., N. D. Croughwell, J. A. Blumenthal, E. Lowry, W. D. White, W. Spillane, R. D. Davis, D. D. Glower, L. R. Smith, and E. P. Mahanna. “Predictors of cognitive decline after cardiac operation.” Ann Thorac Surg 59, no. 5 (May 1995): 1326–30. https://doi.org/10.1016/0003-4975(95)00076-w.
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  - Young, W. L., M. F. Newman, D. Amory, and J. G. Reves. “Cerebral blood flow values during cardiopulmonary bypass: relatively absolute or absolutely relative?” Ann Thorac Surg 59, no. 3 (March 1995): 558–61. https://doi.org/10.1016/0003-4975(95)00028-3.
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  - Burker, E. J., J. A. Blumenthal, M. Feldman, R. Burnett, W. White, L. R. Smith, N. Croughwell, R. Schell, M. Newman, and J. G. Reves. “Depression in male and female patients undergoing cardiac surgery.” Br J Clin Psychol 34, no. 1 (February 1995): 119–28. https://doi.org/10.1111/j.2044-8260.1995.tb01444.x.
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  - Burker, E. J., J. A. Blumenthal, M. Feldman, E. Thyrum, E. Mahanna, W. White, L. R. Smith, J. Lewis, N. Croughwell, and R. Schell. “The Mini Mental State Exam as a predictor of neuropsychological functioning after cardiac surgery.” Int J Psychiatry Med 25, no. 3 (1995): 263–76. https://doi.org/10.2190/VDMB-RJV7-M7UK-YYKG.
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  - Mutch, W. A. C., M. F. Newman, N. D. Croughwell, and J. G. Reves. “Jugular bulb saturation and cognitive dysfunction after cardiopulmonary bypass [6].” Annals of Thoracic Surgery 60, no. 1 (1995): 231–32.
  - Newman, M. F., N. D. Croughwell, and J. G. Reves. “Reply.” The Annals of Thoracic Surgery 60, no. 1 (January 1, 1995): 231–32. https://doi.org/10.1016/S0003-4975(00)80006-5.
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  - Croughwell, N. D., M. F. Newman, J. A. Blumenthal, W. D. White, J. B. Lewis, P. E. Frasco, L. R. Smith, E. A. Thyrum, B. J. Hurwitz, and B. J. Leone. “Jugular bulb saturation and cognitive dysfunction after cardiopulmonary bypass.” Ann Thorac Surg 58, no. 6 (December 1994): 1702–8. https://doi.org/10.1016/0003-4975(94)91666-7.
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  - Newman, M. F., N. D. Croughwell, J. A. Blumenthal, W. D. White, J. B. Lewis, L. R. Smith, P. Frasco, E. A. Towner, R. M. Schell, and B. J. Hurwitz. “Effect of aging on cerebral autoregulation during cardiopulmonary bypass. Association with postoperative cognitive dysfunction.” Circulation 90, no. 5 Pt 2 (November 1994): II243–49.
    Link to Item
  - Newman, M. F., N. D. Croughwell, J. A. Blumenthal, W. D. White, J. B. Lewis, L. R. Smith, P. Frasco, et al. “Effect of aging on cerebral autoregulation during cardiopulmonary bypass: Association with postoperative cognitive dysfunction.” Circulation 90, no. 5 II (November 1, 1994).
  - Olthoff, D., and C. Deutrich. “Monitoring the jugular-venous oxyhemoglobin saturation as a decision aid for normothermic cardiopulmonary bypass.” Anesth Analg 78, no. 2 (February 1994): 403–5. https://doi.org/10.1213/00000539-199402000-00033.
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  - Newman, M., and J. G. Reves. “Pro: midazolam is the sedative of choice to supplement narcotic anesthesia.” J Cardiothorac Vasc Anesth 7, no. 5 (October 1993): 615–19. https://doi.org/10.1016/1053-0770(93)90325-f.
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  - Schell, R. M., F. H. Kern, W. J. Greeley, S. R. Schulman, P. E. Frasco, N. D. Croughwell, M. Newman, and J. G. Reves. “Cerebral blood flow and metabolism during cardiopulmonary bypass.” Anesth Analg 76, no. 4 (April 1993): 849–65. https://doi.org/10.1213/00000539-199304000-00029.
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  - Mather, C. M., F. C. Anaes, L. B. Ready, and M. Newman. “Inflammatory cutaneous reactions to epidural catheters.” Anesthesiology 78, no. 1 (January 1993): 200–203. https://doi.org/10.1097/00000542-199301000-00029.
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  - Croughwell, N., L. R. Smith, T. Quill, M. Newman, W. Greeley, F. Kern, J. Lu, and J. G. Reves. “The effect of temperature on cerebral metabolism and blood flow in adults during cardiopulmonary bypass.” J Thorac Cardiovasc Surg 103, no. 3 (March 1992): 549–54.
    Link to Item
  - Croughwell, N., M. Lyth, T. J. Quill, M. Newman, W. J. Greeley, L. R. Smith, and J. G. Reves. “Diabetic patients have abnormal cerebral autoregulation during cardiopulmonary bypass.” Circulation 82, no. 5 Suppl (November 1990): IV407–12.
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- Book Sections
  - Mackensen, G. B., H. P. Grocott, and M. F. Newman. “Cardiopulmonary bypass and the brain.” In Techniques in Extracorporeal Circulation, Fourth Edition, 148–76, 2004.
- Other Articles
  - Kertai, Miklos D., Yen-Wei Li, Yi-Ju Li, Svati H. Shah, William E. Kraus, Manuel L. Fontes, Mark Stafford-Smith, et al. “G protein-coupled receptor kinase 5 gene polymorphisms are associated with postoperative atrial fibrillation after coronary artery bypass grafting in patients receiving β-blockers.” Circ Cardiovasc Genet, October 2014. https://doi.org/10.1161/CIRCGENETICS.113.000451.
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  - McDonagh, David L., Joseph P. Mathew, Willam D. White, Barbara Phillips-Bute, Daniel T. Laskowitz, Mihai V. Podgoreanu, Mark F. Newman, and Mark F. Neurologic Outcome Research Group. “Cognitive function after major noncardiac surgery, apolipoprotein E4 genotype, and biomarkers of brain injury.” Anesthesiology, April 2010. https://doi.org/10.1097/ALN.0b013e3181d31fd7.
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  - Mackensen, G. B., L. K. Ti, B. G. Phillips-Bute, J. P. Mathew, M. F. Newman, H. P. Grocott, and H. P. Neurologic Outcome Research Group (NORG). “Cerebral embolization during cardiac surgery: impact of aortic atheroma burden.” Br J Anaesth, November 2003. https://doi.org/10.1093/bja/aeg234.
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  - Swaminathan, Madhav, Brian J. McCreath, Barbara G. Phillips-Bute, Mark F. Newman, Joseph P. Mathew, Peter K. Smith, James A. Blumenthal, Mark Stafford-Smith, and Mark Perioperative Outcomes Research Group. “Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction.” Anesth Analg, July 2002. https://doi.org/10.1097/00000539-200207000-00001.
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  - Grigore, Alina M., Hilary P. Grocott, Joseph P. Mathew, Barbara Phillips-Bute, Timothy O. Stanley, Aimee Butler, Kevin P. Landolfo, et al. “The rewarming rate and increased peak temperature alter neurocognitive outcome after cardiac surgery.” Anesth Analg, January 2002. https://doi.org/10.1097/00000539-200201000-00002.
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  - Tardiff, B. E., M. F. Newman, A. M. Saunders, W. J. Strittmatter, J. A. Blumenthal, W. D. White, N. D. Croughwell, R. D. Davis, A. D. Roses, and J. G. Reves. “Preliminary report of a genetic basis for cognitive decline after cardiac operations. The Neurologic Outcome Research Group of the Duke Heart Center.” Ann Thorac Surg, September 1997. https://doi.org/10.1016/s0003-4975(97)00757-1.
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