Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Hematology-Oncology Fellowship, Medicine, Duke University School of Medicine 2011 - 2014
  • Internal Medicine Residency, Medicine, Duke University School of Medicine 2008 - 2011
  • M.D., Duke University School of Medicine 2008
  • Ph.D., Duke University 2007
• 

  Duke Appointment History

  • Medical Instructor in the Department of Medicine, Medicine, Medical Oncology, Medicine 2014 - 2017
• Research
• 

  Selected Grants

  • Incyte 207 2019 - 2024
  • BMS CA209-848 2019 - 2024
  • MedImmune Panc D607C00005 2018 - 2023
  • GRASPANC -Eryaspase 2019 - 2023
  • A Phase 1/2 study of exploring the safety tolerablility and efficacy of Epacadostat in combination with Durvalumab in subjects with selected advanced solid tumors. 2016 - 2021
  • A platform study exploring the safety tolerability effects on the tumor microenvironment and efficacy of Pembroliumab (MK-3475) + INCB combination 2016 - 2021
  • A Phase I open label dose escalation safety and tolerability study of INCB054828 in subjects with advanced malignancies 2015 - 2020
  • AM0010-301 A Randomized Phase 3 Study of AM0010 in Combination with FOLFOX Compared 2017 - 2020
  • BACCI - RU021416 Phase II Study 2017 - 2020
  • OncoMed OMP-313M32 2017 - 2020
  • A Phase 1/2 study of the safety, tolorability and efficacy of INCB24360 administered in combination with Nivolumab in select advanced cancers. 2015 - 2020
  • ATELIER ML39832 PI Initiated 2018
  • A Phase 2 proof of concept study of ACP-196 alone in combination with Pembrolizumab in subjects with advanced or metastatic pancreatic cancer. 2015 - 2018
  • A Multi center study of the Bruton's Tyrosine Kinase (BTK) inhibitor, Ibrutinib in combination with MEDI4736 2015 - 2018
  • Preclinical and Human Correlative Studies of a Novel Bruton Tyronsine Kinase Inhibitor in Pancreatic Cancer awarded by Department of Defense 2016 - 2017
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Overman, Michael, Milind Javle, Richard E. Davis, Pankaj Vats, Chandan Kumar-Sinha, Lianchun Xiao, Niharika B. Mettu, et al. “Randomized phase II study of the Bruton tyrosine kinase inhibitor acalabrutinib, alone or with pembrolizumab in patients with advanced pancreatic cancer.” Journal for Immunotherapy of Cancer 8, no. 1 (February 2020). https://doi.org/10.1136/jitc-2020-000587.
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    • Mettu, Niharika B., and James L. Abbruzzese. “Clinical Insights Into the Biology and Treatment of Pancreatic Cancer.” J Oncol Pract 12, no. 1 (January 2016): 17–23. https://doi.org/10.1200/JOP.2015.009092.
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    • Mettu, Niharika B., Herbert Hurwitz, and David S. Hsu. “Use of molecular biomarkers to inform adjuvant therapy for colon cancer.” Oncology (Williston Park) 27, no. 8 (August 2013): 746–54.
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    • Mettu, N. B., H. Hurwitz, and D. S. Hsu. “Use of molecular biomarkers to inform adjuvant therapy for colon cancer.” Oncology (United States) 27, no. 8 (January 1, 2013).
    • Stanifer, John, Reema Mehta, Niharika Mettu, Jeffrey Sanders, and Noppon Setji. “Muehrcke's lines as a diagnostic clue to increased catabolism and a severe systemic disease state.” Am J Med Sci 342, no. 4 (October 2011): 331. https://doi.org/10.1097/MAJ.0b013e31821fb6d0.
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    • Mettu, Niharika B., Thomas B. Stanley, Mary A. Dwyer, Michelle S. Jansen, John E. Allen, Julie M. Hall, and Donald P. McDonnell. “The nuclear receptor-coactivator interaction surface as a target for peptide antagonists of the peroxisome proliferator-activated receptors.” Mol Endocrinol 21, no. 10 (October 2007): 2361–77. https://doi.org/10.1210/me.2007-0201.
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  • Conference Papers

    • Mettu, Niharika B., Donna Niedzwiecki, Christel Rushing, Andrew B. Nixon, Jingquan Jia, Sherri Haley, Wanda Honeycutt, Herbert Hurwitz, Johanna C. Bendell, and Hope Uronis. “A phase I study of gemcitabine + dasatinib (gd) or gemcitabine + dasatinib + cetuximab (GDC) in refractory solid tumors.” In Cancer Chemother Pharmacol, 83:1025–35, 2019. https://doi.org/10.1007/s00280-019-03805-6.
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