Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellowship, Pediatric Hematology/ Oncology, Duke University School of Medicine 2007 - 2010
  • Fellowship, Adult Hematology/Oncology, East Carolina University 2004 - 2005
  • Resident, Medicine Pediatrics, East Carolina University 2000 - 2004
  • M.D., American University of the Caribbean 2000
• 

  Duke Appointment History

  • Medical Instructor in the Department of Medicine, Medicine, Hematology, Medicine 2010 - 2012
  • Medical Instructor in the Department of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2010 - 2012
  • Instructor Temporary in the Department of Medicine, Medicine, Hematology, Medicine 2010
• Expertise
• 

  Subject Headings

  • Adolescent
  • Adult
  • Child
  • Hematology
  • Hemoglobin, Sickle
  • Pain Management
  • Thrombin
  • Thrombophilia
• 

  Global Scholarship

  • Research

    • Cameroon (Country) 
    • Jamaica (Country) 
    • South Africa (Country) 
• Research
• 

  Selected Grants

  • Improving SCD Care using Web-based Guidelines, Nurse Care Managers and Peer Mentors in Parimary Care Emergency Departments in Central North Carolina awarded by National Institutes of Health 2016 - 2022
  • GBT 440-034 awarded by  Global Blood Therapeutics, Inc. 2018 - 2022
  • A Double-blind, Randomized, Placebo-controlled, Multicenter Study of GBT440 Administered Orally to Subjects with Sickle Cell Disease awarded by  Global Blood Therapeutics, Inc. 2017 - 2022
  • Phase II study to assess SEG101 in Sickle Cell Patients awarded by Novartis Pharmaceuticals Corporation 2018 - 2022
  • Technology-Mediated Symptom Management in Pediatric Blood and Marrow Transplant Care awarded by National Institutes of Health 2018 - 2021
  • Transfusion Medicine and Hematology awarded by National Institutes of Health 1975 - 2021
  • Open Label study to evaluate the safety and Pharmacokinetics of PF-06412528 in children 7-17 for treatment of moderate to severe pain awarded by Pfizer, Inc. 2018 - 2021
  • Disseminating NIH Evidence Based Sickle Cell Recommendations in North Carolina awarded by Agency for Healthcare Research and Quality 2016 - 2020
  • AZD9668 and Neutrophil Elastase Inhibition to Prevent Graft-versus-Host Disease awarded by National Institutes of Health 2018 - 2019
  • Impact of Sickle-Trait on Transcriptional Regulation in P. Falciparum Parasites awarded by National Institutes of Health 2017 - 2019
  • SUCCESSOR Chart Review awarded by Novartis Pharmaceuticals Corporation 2018
  • DU176b-A-U157/ A Phase 1, Open-Label, Single-Dose Non-Randomized Study To Evaluate Pharmacokinetics And Pharmacodynamics of Edoxaban In Pediatric Patients awarded by Daiichi Sankyo Inc 2015 - 2018
  • Use of Mobile Technology to Improve Acute Care Utilization in Sickle Cell Disease awarded by Agency for Healthcare Research and Quality 2015 - 2018
  • EINSTEIN Junior Phase III: oral rivaroxaban in children with venous thrombosis awarded by Bayer Healthcare Pharmaceuticals Inc 2015 - 2018
  • Improving Pain in Sickle Cell Patients With Targeted Antithrombotic Therapy awarded by National Institutes of Health 2014 - 2017
  • EPIC: Evaluation of purified poloxamer 188 in children in crisis awarded by : Mast Therapeutics, Inc. 2014 - 2017
  • EVALUATION OF REPEAT ADMINISTRATION OF PURIFIED POLOXAMER 188 IN VASO-OCCLUSIVE CRISIS OF SICKLE CELL DISEASE (EPIC-E): AN OPEN-LABEL SAFETY EXTENSION TRIAL ASSESSING REPEAT ADMINISTRATION OF MST-188 awarded by : Mast Therapeutics, Inc. 2016 - 2017
  • SUSTAIN awarded by Selexys Pharmaceuticals, Corp 2014 - 2017
  • QuBBD: Collaborative Research: Advancing mHealth using Big Data Analytics: Statistical and Dynamical Systems Modeling of Real-Time Adaptive m-Intervention for Pain awarded by  National Science Foundation 2015 - 2016
  • Apixaban SC awarded by Bristol-Myers Squibb 2013 - 2016
  • Use of Mobile Technology for Intensive Training in Medication Management awarded by Sickle Soft Incorporated 2014 - 2016
  • Population-based Surveillance And Outcomes of Venous Thromboembolism awarded by Centers for Disease Control and Prevention 2012 - 2015
• Publications & Artistic Works
• 

  Selected Publications

  • Conference Papers

    • Clifton, SM, Kang, C, Li, JJ, Long, Q, Shah, N, and Abrams, DM. "Hybrid Statistical and Mechanistic Mathematical Model Guides Mobile Health Intervention for Chronic Pain." July 2017.  Full Text

  • Journal Articles

    • Kayle, M, Docherty, SL, Sloane, R, Tanabe, P, Maslow, G, Pan, W, and Shah, N. "Transition to adult care in sickle cell disease: A longitudinal study of clinical characteristics and disease severity." Pediatric Blood & Cancer (September 24, 2018): e27463-null.  Full Text
    • Vaughn, J, Jonassaint, J, Summers-Goeckerman, E, Shaw, RJ, and Shah, N. "Customization of the TRU-PBMT App (Technology Recordings to better Understand Pediatric Blood and Marrow Transplant)." Journal of Pediatric Nursing 42 (September 2018): 86-91.  Full Text
    • Anderson, LM, Leonard, S, Jonassaint, J, Lunyera, J, Bonner, M, and Shah, N. "Mobile health intervention for youth with sickle cell disease: Impact on adherence, disease knowledge, and quality of life." Pediatric Blood & Cancer 65, no. 8 (August 2018): e27081-e27081.  Full Text
    • Jooste, EH, Scholl, R, Wu, Y-H, Jaquiss, RDB, Lodge, AJ, Ames, WA, Homi, HM, Machovec, KA, Greene, NH, Donahue, BS, Shah, N, and Benkwitz, C. "Double-Blind, Randomized, Placebo-Controlled Trial Comparing the Effects of Antithrombin Versus Placebo on the Coagulation System in Infants with Low Antithrombin Undergoing Congenital Cardiac Surgery." Journal of Cardiothoracic and Vascular Anesthesia (June 5, 2018).  Full Text
    • Sullivan, KM, Horwitz, M, Osunkwo, I, Shah, N, and Strouse, JJ. "Shared Decision-Making in Hematopoietic Stem Cell Transplantation for Sickle Cell Disease." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 24, no. 5 (May 2018): 883-884.  Full Text
    • Klein, NP, Habanec, T, Kosina, P, Shah, NR, Kolhe, D, Miller, JM, Hezareh, M, and Van der Wielen, M. "Immunogenicity and safety of the quadrivalent meningococcal ACWY-tetanus toxoid conjugate vaccine (MenACWY-TT) in splenectomized or hyposplenic children and adolescents: Results of a phase III, open, non-randomized study." Vaccine 36, no. 17 (April 2018): 2356-2363.  Full Text
    • Badawy, SM, Cronin, RM, Hankins, J, Crosby, L, DeBaun, M, Thompson, AA, and Shah, N. "Patient-Centered eHealth Interventions for Children, Adolescents, and Adults With Sickle Cell Disease: Systematic Review." Journal of Medical Internet Research 20, no. 7 (2018): e10940-e10940.  Full Text
    • Culp-Hill, R, Srinivasan, J, Gehrke, S, Kamyszek, R, Ansari, A, Shah, N, Welsby, I, and D'Alessandro, A. "Effects of red blood cell (RBC) transfusion on sickle cell disease recipient plasma and RBC metabolism(Accepted)." Transfusion (January 1, 2018).  Full Text
    • Leonard, S, Anderson, LM, Jonassaint, J, Jonassaint, C, and Shah, N. "Utilizing a Novel Mobile Health "Selfie" Application to Improve Compliance to Iron Chelation in Pediatric Patients Receiving Chronic Transfusions." Journal of Pediatric Hematology/Oncology 39, no. 3 (April 2017): 223-229.  Full Text
    • Lunyera, J, Jonassaint, C, Jonassaint, J, and Shah, N. "Attitudes of Primary Care Physicians Toward Sickle Cell Disease Care, Guidelines, and Comanaging Hydroxyurea With a Specialist." Journal of Primary Care & Community Health 8, no. 1 (January 2017): 37-40.  Full Text
    • Shah, NR. "Advances in iron chelation therapy: transitioning to a new oral formulation." Drugs in context 6 (January 2017): 212502-.  Full Text
    • Kayle, M, Tanabe, P, Shah, NR, Baker-Ward, L, and Docherty, SL. "Challenges in Shifting Management Responsibility From Parents to Adolescents With Sickle Cell Disease." Journal of pediatric nursing 31, no. 6 (November 2016): 678-690.  Full Text
    • Wang, H-HS, Herbst, KW, Rothman, JA, Shah, NR, Wiener, JS, and Routh, JC. "Trends in Sickle Cell Disease-related Priapism in U.S. Children's Hospitals." Urology 89 (March 2016): 118-122.  Full Text
    • Goldenberg, NA, Abshire, T, Blatchford, PJ, Fenton, LZ, Halperin, JL, Hiatt, WR, Kessler, CM, Kittelson, JM, Manco-Johnson, MJ, Spyropoulos, AC, Steg, PG, Stence, NV, Turpie, AGG, Schulman, S, and Kids-DOTT Trial Investigators, . "Multicenter randomized controlled trial on Duration of Therapy for Thrombosis in Children and Young Adults (the Kids-DOTT trial): pilot/feasibility phase findings." Journal of Thrombosis and Haemostasis : Jth 13, no. 9 (September 2015): 1597-1605.  Full Text
    • Shah, N, Welsby, IJ, Fielder, MA, Jacobsen, WK, and Nielsen, VG. "Sickle cell disease is associated with iron mediated hypercoagulability." Journal of thrombosis and thrombolysis 40, no. 2 (August 2015): 182-185.  Full Text
    • Jonassaint, CR, Shah, N, Jonassaint, J, and De Castro, L. "Usability and Feasibility of an mHealth Intervention for Monitoring and Managing Pain Symptoms in Sickle Cell Disease: The Sickle Cell Disease Mobile Application to Record Symptoms via Technology (SMART)." Hemoglobin 39, no. 3 (January 2015): 162-168.  Full Text
    • Shah, N, Rollins, M, Landi, D, Shah, R, Bae, J, and De Castro, LM. "Differences in pain management between hematologists and hospitalists caring for patients with sickle cell disease hospitalized for vasoocclusive crisis." The Clinical Journal of Pain 30, no. 3 (March 2014): 266-268.  Full Text
    • Shah, N, Jonassaint, J, and De Castro, L. "Patients welcome the Sickle Cell Disease Mobile Application to Record Symptoms via Technology (SMART)." Hemoglobin 38, no. 2 (January 2014): 99-103.  Full Text
    • Shah, N, Rollins, M, Landi, D, Shah, R, Bae, J, and Castro, LMD. "Differences in pain management between hematologists and hospitalists caring for patients with sickle cell disease hospitalized for vasoocclusive crisis." Clinical Journal of Pain 30, no. 3 (2014): 266-268.  Full Text
    • Landi, D, Beckman, MG, Shah, NR, Bockenstedt, P, Grant, AM, Heit, JA, Key, NS, Kulkarni, R, Manco-Johnson, M, Moll, S, Philipp, CS, Andersen, JC, and Ortel, TL. "Characteristics of abdominal vein thrombosis in children and adults." Thrombosis and Haemostasis 109, no. 4 (April 2013): 625-632.  Full Text
    • Shah, N, Thornburg, C, Telen, MJ, and Ortel, TL. "Characterization of the hypercoagulable state in patients with sickle cell disease." Thrombosis Research 130, no. 5 (November 2012): e241-e245.  Full Text
    • Verhovsek, M, Shah, NR, Wilcox, I, Koenig, SC, Barros, T, Thornburg, CD, Steinberg, MH, Luo, H-Y, and Chui, DHK. "Severe fetal and neonatal hemolytic anemia due to a 198 kb deletion removing the complete β-globin gene cluster." Pediatr Blood Cancer 59, no. 5 (November 2012): 941-944.  Full Text  Link to Item
    • Shah, NR, Ortel, T, Thames, E, and James, AH. "Changes in Thrombin Generation During Pregnancy as Measured by Computerized Automated Thrombography (Cat)." AMERICAN JOURNAL OF HEMATOLOGY 87 (May 2012): S170-S170.  Link to Item
    • Shah, N, Landi, D, Shah, R, Rothman, J, De Castro, LM, and Thornburg, CD. "Complications of implantable venous access devices in patients with sickle cell disease." American Journal of Hematology 87, no. 2 (February 2012): 224-226.  Full Text
    • Shah, NR, Landi, DB, Kreissman, SG, Kulbachi, E, and Moran, C. "Presentation and outcomes for children with bone marrow necrosis and acute lymphoblastic leukemia: a literature review." J Pediatr Hematol Oncol 33, no. 7 (October 2011): e316-e319. (Review)  Full Text  Link to Item
    • Shah, NR, Telen, M, and Ortel, T. "Evaluation of thrombin generation in sickle cell patients and correlation to clinical disease." JOURNAL OF THROMBOSIS AND HAEMOSTASIS 9 (July 2011): 836-836.  Link to Item
    • Jonassaint, C, Rao, N, Sciuto, A, Switzer, G, De Castro, L, Kato, G, Jonassaint H., J, Hammal, Z, Shah, N, and Wasan, A. "Using Abstract Animations as an Innovative Technology-Based Approach to Measuring Pain in Adults (Preprint)(Published online)." Journal of Medical Internet Research .  Full Text
• Scholarly, Clinical, & Service Activities
• 

  Outreach & Engaged Scholarship

  • Bass Connections Faculty Team Member . Integrative Global Health Research on Sickle Cell Disease . August 2015 - May 2016  2015 - 2016
  • Bass Connections Faculty Team Member. Integrative Global Health Research on Sickle Cell Disease . August 2014 - May 2015  2014 - 2015

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.