Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellowship, Pediatric Hematology/ Oncology, Duke University School of Medicine 2007 - 2010
  • Fellowship, Adult Hematology/Oncology, East Carolina University 2004 - 2005
  • Resident, Medicine Pediatrics, East Carolina University 2000 - 2004
  • M.D., American University of the Caribbean 2000
• 

  Duke Appointment History

  • Assistant Professor in Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2012 - 2019
  • Assistant Professor of Medicine, Medicine, Hematology, Medicine 2012 - 2019
  • Medical Instructor in the Department of Medicine, Medicine, Hematology, Medicine 2010 - 2012
  • Medical Instructor in the Department of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2010 - 2012
  • Instructor Temporary in the Department of Medicine, Medicine, Hematology, Medicine 2010
• Expertise
• 

  Subject Headings

  • Adolescent
  • Adult
  • Child
  • Hematology
  • Hemoglobin, Sickle
  • Pain Management
  • Thrombin
  • Thrombophilia
• 

  Global Scholarship

  • Research

    • Cameroon (Country) 
    • Jamaica (Country) 
    • South Africa (Country) 
• Research
• 

  Selected Grants

  • GBT 440-037 2019 - 2024
  • Improving SCD Care using Web-based Guidelines, Nurse Care Managers and Peer Mentors in Parimary Care Emergency Departments in Central North Carolina awarded by National Institutes of Health 2016 - 2022
  • GBT 440-034 2018 - 2022
  • A Double-blind, Randomized, Placebo-controlled, Multicenter Study of GBT440 Administered Orally to Subjects with Sickle Cell Disease 2017 - 2022
  • Phase II study to assess SEG101 in Sickle Cell Patients 2018 - 2022
  • Imara SCD-102 2019 - 2021
  • Technology-Mediated Symptom Management in Pediatric Blood and Marrow Transplant Care awarded by National Institutes of Health 2018 - 2021
  • Transfusion Medicine and Hematology awarded by National Institutes of Health 1975 - 2021
  • SCH: INT: Collaborative Research: Development and analysis of integrative models for chronic pain awarded by Northwestern University 2018 - 2020
  • Disseminating NIH Evidence Based Sickle Cell Recommendations in North Carolina awarded by Agency for Healthcare Research and Quality 2016 - 2020
  • SICKLE CELL DISEASE STRUCTURED TRANSITION EDUCATION INTERVENTION WITH PEER MENTORING SUPPORT TO IMPROVING CARE TRANSITIONS (SCD STEP-UP PROGRAM) 2018 - 2020
  • Impact of Sickle-Trait on Transcriptional Regulation in P. Falciparum Parasites awarded by National Institutes of Health 2017 - 2020
  • AZD9668 and Neutrophil Elastase Inhibition to Prevent Graft-versus-Host Disease awarded by National Institutes of Health 2018 - 2019
  • Open Label study to evaluate the safety and Pharmacokinetics of PF-06412528 in children 7-17 for treatment of moderate to severe pain 2018 - 2019
  • DU176b-A-U157/ A Phase 1, Open-Label, Single-Dose Non-Randomized Study To Evaluate Pharmacokinetics And Pharmacodynamics of Edoxaban In Pediatric Patients 2015 - 2019
  • SUCCESSOR Chart Review 2018 - 2019
  • Use of Mobile Technology to Improve Acute Care Utilization in Sickle Cell Disease awarded by Agency for Healthcare Research and Quality 2015 - 2018
  • EINSTEIN Junior Phase III: oral rivaroxaban in children with venous thrombosis 2015 - 2018
  • Improving Pain in Sickle Cell Patients With Targeted Antithrombotic Therapy awarded by National Institutes of Health 2014 - 2017
  • EPIC: Evaluation of purified poloxamer 188 in children in crisis 2014 - 2017
  • EVALUATION OF REPEAT ADMINISTRATION OF PURIFIED POLOXAMER 188 IN VASO-OCCLUSIVE CRISIS OF SICKLE CELL DISEASE (EPIC-E): AN OPEN-LABEL SAFETY EXTENSION TRIAL ASSESSING REPEAT ADMINISTRATION OF MST-188 2016 - 2017
  • SUSTAIN 2014 - 2017
  • QuBBD: Collaborative Research: Advancing mHealth using Big Data Analytics: Statistical and Dynamical Systems Modeling of Real-Time Adaptive m-Intervention for Pain awarded by  National Science Foundation 2015 - 2016
  • Apixaban SC 2013 - 2016
  • Use of Mobile Technology for Intensive Training in Medication Management 2014 - 2016
  • Population-based Surveillance And Outcomes of Venous Thromboembolism 2012 - 2015
• 

  External Relationships

  • Alexion
  • CSL Behring AG
  • Global Blood Therapeutics
  • Lab39
  • Novartis
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Crego, Nancy, Christian Douglas, Emily Bonnabeau, Marian Earls, Kern Eason, Elizabeth Merwin, Gary Rains, Paula Tanabe, and Nirmish Shah. “Sickle-Cell Disease Co-Management, Health Care Utilization, and Hydroxyurea Use.” J Am Board Fam Med 33, no. 1 (January 2020): 91–105. https://doi.org/10.3122/jabfm.2020.01.190143.
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    • Johnson, Amanda, Fan Yang, Siddharth Gollarahalli, Tanvi Banerjee, Daniel Abrams, Jude Jonassaint, Charles Jonassaint, and Nirmish Shah. “Use of Mobile Health Apps and Wearable Technology to Assess Changes and Predict Pain During Treatment of Acute Pain in Sickle Cell Disease: Feasibility Study.” Jmir Mhealth Uhealth 7, no. 12 (December 2, 2019): e13671. https://doi.org/10.2196/13671.
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    • Shah, Nirmish, Menaka Bhor, Lin Xie, Rashid Halloway, Steve Arcona, Jincy Paulose, and Huseyin Yuce. “Treatment patterns and economic burden of sickle-cell disease patients prescribed hydroxyurea: a retrospective claims-based study.” Health Qual Life Outcomes 17, no. 1 (October 16, 2019): 155. https://doi.org/10.1186/s12955-019-1225-7.
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    • Gehrke, Sarah, Nirmish Shah, Fabia Gamboni, Reed Kamyszek, Amudan J. Srinivasan, Alan Gray, Matthew Landrigan, Ian Welsby, and Angelo D’Alessandro. “Metabolic impact of red blood cell exchange with rejuvenated red blood cells in sickle cell patients.” Transfusion 59, no. 10 (October 2019): 3102–12. https://doi.org/10.1111/trf.15467.
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    • Hart, Laura C., McLean Pollock, Audrey Brown, Nirmish Shah, Richard J. Chung, Richard Sloane, and Gary R. Maslow. “Where Did They Go? Tracking Young Adult Follow-up During the Transition From Pediatric to Adult-Oriented Care.” Clin Pediatr (Phila) 58, no. 11–12 (October 2019): 1277–83. https://doi.org/10.1177/0009922819852980.
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    • Kamyszek, Reed W., Jay S. Raval, Amudan J. Srinivasan, Andrea K. Ansari, Brooke A. Evans, Marian A. Rollins-Raval, Jessica L. Poisson, Nirmish R. Shah, and Ian J. Welsby. “Interval decline in hemoglobin A is associated with annual clinical event rate in sickle cell anemia patients receiving maintenance apheresis RBC exchange.” Transfusion 59, no. 8 (August 2019): 2622–28. https://doi.org/10.1111/trf.15386.
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    • Jooste, Edmund H., Rebecca Scholl, Yi-Hung Wu, Robert D. B. Jaquiss, Andrew J. Lodge, Warwick A. Ames, H Mayumi Homi, et al. “Double-Blind, Randomized, Placebo-Controlled Trial Comparing the Effects of Antithrombin Versus Placebo on the Coagulation System in Infants with Low Antithrombin Undergoing Congenital Cardiac Surgery.” J Cardiothorac Vasc Anesth 33, no. 2 (February 2019): 396–402. https://doi.org/10.1053/j.jvca.2018.05.052.
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    • Kayle, Mariam, Sharron L. Docherty, Richard Sloane, Paula Tanabe, Gary Maslow, Wei Pan, and Nirmish Shah. “Transition to adult care in sickle cell disease: A longitudinal study of clinical characteristics and disease severity.” Pediatr Blood Cancer 66, no. 1 (January 2019): e27463. https://doi.org/10.1002/pbc.27463.
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    • Masese, Rita Vanessa, Dominique Bulgin, Christian Douglas, Nirmish Shah, and Paula Tanabe. “Barriers and facilitators to care for individuals with sickle cell disease in central North Carolina: The emergency department providers' perspective.” Plos One 14, no. 5 (2019): e0216414. https://doi.org/10.1371/journal.pone.0216414.
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    • Shah, Nirmish, Menaka Bhor, Lin Xie, Jincy Paulose, and Huseyin Yuce. “Sickle cell disease complications: Prevalence and resource utilization.” Plos One 14, no. 7 (2019): e0214355. https://doi.org/10.1371/journal.pone.0214355.
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    • Culp-Hill, Rachel, Amudan J. Srinivasan, Sarah Gehrke, Reed Kamyszek, Andrea Ansari, Nirmish Shah, Ian Welsby, and Angelo D’Alessandro. “Effects of red blood cell (RBC) transfusion on sickle cell disease recipient plasma and RBC metabolism.” Transfusion 58, no. 12 (December 2018): 2797–2806. https://doi.org/10.1111/trf.14931.
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    • DiMartino, Lisa D., Ana A. Baumann, Lewis L. Hsu, Julie Kanter, Victor R. Gordeuk, Jeffrey Glassberg, Marsha J. Treadwell, et al. “The sickle cell disease implementation consortium: Translating evidence-based guidelines into practice for sickle cell disease.” Am J Hematol 93, no. 12 (December 2018): E391–95. https://doi.org/10.1002/ajh.25282.
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    • Jonassaint, Charles R., Chaeryon Kang, Daniel M. Abrams, Jingyi J. Li, Jason Mao, Yimeng Jia, Qi Long, et al. “Understanding patterns and correlates of daily pain using the Sickle cell disease Mobile Application to Record Symptoms via Technology (SMART).” Br J Haematol 183, no. 2 (October 2018): 306–8. https://doi.org/10.1111/bjh.14956.
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    • Vaughn, Jacqueline, Jude Jonassaint, Erika Summers-Goeckerman, Ryan J. Shaw, and Nirmish Shah. “Customization of the TRU-PBMT App (Technology Recordings to better Understand Pediatric Blood and Marrow Transplant).” J Pediatr Nurs 42 (September 2018): 86–91. https://doi.org/10.1016/j.pedn.2018.07.007.
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    • Jonassaint, Charles R., Nema Rao, Alex Sciuto, Galen E. Switzer, Laura De Castro, Gregory J. Kato, Jude C. Jonassaint, Zakia Hammal, Nirmish Shah, and Ajay Wasan. “Abstract Animations for the Communication and Assessment of Pain in Adults: Cross-Sectional Feasibility Study.” J Med Internet Res 20, no. 8 (August 3, 2018): e10056. https://doi.org/10.2196/10056.
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    • Anderson, Lindsay M., Sarah Leonard, Jude Jonassaint, Joseph Lunyera, Melanie Bonner, and Nirmish Shah. “Mobile health intervention for youth with sickle cell disease: Impact on adherence, disease knowledge, and quality of life.” Pediatr Blood Cancer 65, no. 8 (August 2018): e27081. https://doi.org/10.1002/pbc.27081.
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    • Badawy, Sherif M., Robert M. Cronin, Jane Hankins, Lori Crosby, Michael DeBaun, Alexis A. Thompson, and Nirmish Shah. “Patient-Centered eHealth Interventions for Children, Adolescents, and Adults With Sickle Cell Disease: Systematic Review.” J Med Internet Res 20, no. 7 (July 19, 2018): e10940. https://doi.org/10.2196/10940.
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    • Yang, Fan, Tanvi Banerjee, Kalindi Narine, and Nirmish Shah. “Improving Pain Management in Patients with Sickle Cell Disease from Physiological Measures Using Machine Learning Techniques.” Smart Health (Amst) 7–8 (June 2018): 48–59. https://doi.org/10.1016/j.smhl.2018.01.002.
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    • Sullivan, Keith M., Mitchell Horwitz, Ifeyinwa Osunkwo, Nirmish Shah, and John J. Strouse. “Shared Decision-Making in Hematopoietic Stem Cell Transplantation for Sickle Cell Disease.” Biol Blood Marrow Transplant 24, no. 5 (May 2018): 883–84. https://doi.org/10.1016/j.bbmt.2018.04.001.
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    • Klein, Nicola P., Tomas Habanec, Pavel Kosina, Nirmish R. Shah, Devayani Kolhe, Jacqueline M. Miller, Marjan Hezareh, and Marie Van der Wielen. “Immunogenicity and safety of the quadrivalent meningococcal ACWY-tetanus toxoid conjugate vaccine (MenACWY-TT) in splenectomized or hyposplenic children and adolescents: Results of a phase III, open, non-randomized study.” Vaccine 36, no. 17 (April 19, 2018): 2356–63. https://doi.org/10.1016/j.vaccine.2018.02.085.
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    • Sobota, Amy E., Nishita Shah, and Jennifer W. Mack. “Development of quality indicators for transition from pediatric to adult care in sickle cell disease: A modified Delphi survey of adult providers.” Pediatr Blood Cancer 64, no. 6 (June 2017). https://doi.org/10.1002/pbc.26374.
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    • Leonard, Sarah, Lindsay M. Anderson, Jude Jonassaint, Charles Jonassaint, and Nirmish Shah. “Utilizing a Novel Mobile Health "Selfie" Application to Improve Compliance to Iron Chelation in Pediatric Patients Receiving Chronic Transfusions.” J Pediatr Hematol Oncol 39, no. 3 (April 2017): 223–29. https://doi.org/10.1097/MPH.0000000000000743.
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    • Lunyera, Joseph, Charles Jonassaint, Jude Jonassaint, and Nirmish Shah. “Attitudes of Primary Care Physicians Toward Sickle Cell Disease Care, Guidelines, and Comanaging Hydroxyurea With a Specialist.” J Prim Care Community Health 8, no. 1 (January 2017): 37–40. https://doi.org/10.1177/2150131916662969.
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    • Shah, Nirmish R. “Advances in iron chelation therapy: transitioning to a new oral formulation.” Drugs Context 6 (2017): 212502. https://doi.org/10.7573/dic.212502.
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    • Kayle, Mariam, Paula Tanabe, Nirmish R. Shah, Lynne Baker-Ward, and Sharron L. Docherty. “Challenges in Shifting Management Responsibility From Parents to Adolescents With Sickle Cell Disease.” J Pediatr Nurs 31, no. 6 (November 2016): 678–90. https://doi.org/10.1016/j.pedn.2016.06.008.
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    • Wang, Hsin-Hsiao Scott, Katherine W. Herbst, Jennifer A. Rothman, Nirmish R. Shah, John S. Wiener, and Jonathan C. Routh. “Trends in Sickle Cell Disease-related Priapism in U.S. Children's Hospitals.” Urology 89 (March 2016): 118–22. https://doi.org/10.1016/j.urology.2015.11.023.
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    • Goldenberg, N. A., T. Abshire, P. J. Blatchford, L. Z. Fenton, J. L. Halperin, W. R. Hiatt, C. M. Kessler, et al. “Multicenter randomized controlled trial on Duration of Therapy for Thrombosis in Children and Young Adults (the Kids-DOTT trial): pilot/feasibility phase findings.” J Thromb Haemost 13, no. 9 (September 2015): 1597–1605. https://doi.org/10.1111/jth.13038.
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    • Shah, Nirmish, Ian J. Welsby, Martha A. Fielder, Wayne K. Jacobsen, and Vance G. Nielsen. “Sickle cell disease is associated with iron mediated hypercoagulability.” Journal of Thrombosis and Thrombolysis 40, no. 2 (August 2015): 182–85. https://doi.org/10.1007/s11239-015-1230-6.
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    • Jonassaint, Charles R., Nirmish Shah, Jude Jonassaint, and Laura De Castro. “Usability and Feasibility of an mHealth Intervention for Monitoring and Managing Pain Symptoms in Sickle Cell Disease: The Sickle Cell Disease Mobile Application to Record Symptoms via Technology (SMART).” Hemoglobin 39, no. 3 (2015): 162–68. https://doi.org/10.3109/03630269.2015.1025141.
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    • Shah, Nirmish, Margo Rollins, Daniel Landi, Radhika Shah, Jonathan Bae, and Laura M. De Castro. “Differences in pain management between hematologists and hospitalists caring for patients with sickle cell disease hospitalized for vasoocclusive crisis.” Clin J Pain 30, no. 3 (March 2014): 266–68. https://doi.org/10.1097/AJP.0b013e318295ec04.
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    • Shah, Nirmish, Jude Jonassaint, and Laura De Castro. “Patients welcome the Sickle Cell Disease Mobile Application to Record Symptoms via Technology (SMART).” Hemoglobin 38, no. 2 (2014): 99–103. https://doi.org/10.3109/03630269.2014.880716.
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    • Landi, Daniel, Michele G. Beckman, Nirmish R. Shah, Paula Bockenstedt, Althea M. Grant, John A. Heit, Nigel S. Key, et al. “Characteristics of abdominal vein thrombosis in children and adults.” Thromb Haemost 109, no. 4 (April 2013): 625–32. https://doi.org/10.1160/TH12-08-0568.
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    • Shah, Nirmish, Courtney Thornburg, Marilyn J. Telen, and Thomas L. Ortel. “Characterization of the hypercoagulable state in patients with sickle cell disease.” Thrombosis Research 130, no. 5 (November 2012): e241–45. https://doi.org/10.1016/j.thromres.2012.08.307.
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    • Verhovsek, Madeleine, Nirmish R. Shah, Ibifiri Wilcox, Sara C. Koenig, Tiago Barros, Courtney D. Thornburg, Martin H. Steinberg, Hong-yuan Luo, and David H. K. Chui. “Severe fetal and neonatal hemolytic anemia due to a 198 kb deletion removing the complete β-globin gene cluster.” Pediatr Blood Cancer 59, no. 5 (November 2012): 941–44. https://doi.org/10.1002/pbc.24094.
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    • Shah, Nirmish R., Thomas Ortel, Elizabeth Thames, and Andra H. James. “Changes in Thrombin Generation During Pregnancy as Measured by Computerized Automated Thrombography (Cat).” American Journal of Hematology 87 (May 1, 2012): S170–S170.
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    • Shah, Nirmish, Daniel Landi, Radhika Shah, Jennifer Rothman, Laura M. De Castro, and Courtney D. Thornburg. “Complications of implantable venous access devices in patients with sickle cell disease.” Am J Hematol 87, no. 2 (February 2012): 224–26. https://doi.org/10.1002/ajh.22230.
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    • Shah, Nirmish R., Daniel B. Landi, Susan G. Kreissman, Evan Kulbachi, and Cassandra Moran. “Presentation and outcomes for children with bone marrow necrosis and acute lymphoblastic leukemia: a literature review.” J Pediatr Hematol Oncol 33, no. 7 (October 2011): e316–19. https://doi.org/10.1097/MPH.0b013e318223fe9b.
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    • Shah, N. R., M. Telen, and T. Ortel. “Evaluation of thrombin generation in sickle cell patients and correlation to clinical disease.” Journal of Thrombosis and Haemostasis 9 (July 1, 2011): 836–836.
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    • Vaughn, Jacqueline, Erika Summers-Goeckerman, Ryan J. Shaw, and Nirmish Shah. “A Protocol to Assess Feasibility, Acceptability, and Usability of Mobile Technology for Symptom Management in Pediatric Transplant Patients.” Nurs Res 68, no. 4 (n.d.): 317–23. https://doi.org/10.1097/NNR.0000000000000343.
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    • Vaughn, Jacqueline, Siddharth Gollarahalli, Ryan J. Shaw, Sharron Docherty, Qing Yang, Chandni Malhotra, Erika Summers-Goeckerman, and Nirmish Shah. “Mobile Health Technology for Pediatric Symptom Monitoring: A Feasibility Study.” Nurs Res 69, no. 2 (n.d.): 142–48. https://doi.org/10.1097/NNR.0000000000000403.
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  • Conference Papers

    • Clifton, Sara M., Chaeryon Kang, Jingyi Jessica Li, Qi Long, Nirmish Shah, and Daniel M. Abrams. “Hybrid Statistical and Mechanistic Mathematical Model Guides Mobile Health Intervention for Chronic Pain.” In J Comput Biol, 24:675–88, 2017. https://doi.org/10.1089/cmb.2017.0059.
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• Scholarly, Clinical, & Service Activities
• 

  Outreach & Engaged Scholarship

  • Bass Connections Faculty Team Member . Integrative Global Health Research on Sickle Cell Disease . August 2015 - May 2016  2015 - 2016
  • Bass Connections Faculty Team Member. Integrative Global Health Research on Sickle Cell Disease . August 2014 - May 2015  2014 - 2015

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