Nirmish Ramesh Shah
Associate Professor of Medicine
Current Appointments & Affiliations
- Associate Professor of Medicine, Medicine, Hematology, Medicine 2019
- Associate Professor in Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2019
- Associate Professor in the School of Nursing, School of Nursing, Duke University 2019
Contact Information
- Department of Medicine, Duke S, Durham, NC 27710
- Department of Medicine, Duke S, Durham, NC 27710
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nirmish.shah@duke.edu
(919) 668-5178
- Background
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Education, Training, & Certifications
- Fellowship, Pediatric Hematology/ Oncology, Duke University School of Medicine 2007 - 2010
- Fellowship, Adult Hematology/Oncology, East Carolina University 2004 - 2005
- Resident, Medicine Pediatrics, East Carolina University 2000 - 2004
- M.D., American University of the Caribbean 2000
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Previous Appointments & Affiliations
- Assistant Professor in Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2012 - 2019
- Assistant Professor of Medicine, Medicine, Hematology, Medicine 2012 - 2019
- Medical Instructor in the Department of Medicine, Medicine, Hematology, Medicine 2010 - 2012
- Medical Instructor in the Department of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2010 - 2012
- Instructor Temporary in the Department of Medicine, Medicine, Hematology, Medicine 2010
- Expertise
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Subject Headings
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Global Scholarship
- Research
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Selected Grants
- GBT 440-4R2 Prospective Registry awarded by Global Blood Therapeutics, Inc. 2021 - 2026
- Hematology & Transfusion Medicine (T32) awarded by National Institutes of Health 1975 - 2026
- AKIRA Bio study awarded by AkiraBio, Inc 2022 - 2025
- GBT-2104-132 awarded by Global Blood Therapeutics, Inc. 2021 - 2024
- An Open-Label, Expanded Access Protocol for Patients with Sickle Cell Disease Who Have No Alternative Treatment Options - GBT 440-037 awarded by Global Blood Therapeutics, Inc. 2019 - 2024
- Epigenetic Age Acceleration and Psychoneurological Symptoms in Sickle Cell Disease awarded by National Institutes of Health 2022 - 2024
- Feasibility Study of a Mobile Digital Personal Health Record for Family-Partnered Care Coordination for Children and Youth with Special Healthcare Needs awarded by Agency for Healthcare Research and Quality 2021 - 2023
- GBT440-039 A Phase 4, Multicenter, Open-label Study to Evaluate the Treatment Effect of Voxelotor on Physical Activity in Adolescents and Adults with Sickle Cell Disease awarded by Global Blood Therapeutics, Inc. 2020 - 2023
- GBT 440-4R1 Retrospective Registry awarded by Global Blood Therapeutics, Inc. 2021 - 2023
- A Phase II trial of topical sodium nitrite in patients with sickle cell disease and leg ulcers Cost Reimbursable awarded by Food and Drug Administration 2017 - 2022
- Central Carolinas Clinical Trials Collaboration (C3TC) awarded by American Society of Hematology 2021 - 2022
- Hybrid Effectiveness-Implementation Trial of Guided Relaxation and Acupuncture for Chronic Sickle Cell Disease Pain awarded by University of Illinois at Chicago 2020 - 2022
- SCH: INT: Collaborative Research: Development and analysis of integrative models for chronic pain awarded by Northwestern University 2018 - 2022
- Improving SCD Care using Web-based Guidelines, Nurse Care Managers and Peer Mentors in Parimary Care Emergency Departments in Central North Carolina awarded by National Institutes of Health 2016 - 2022
- An Open label extension study of GBT440 administered orally to patients with sickle cell disease who have participated in GBT440 clinical trials awarded by Global Blood Therapeutics, Inc. 2018 - 2022
- SICKLE CELL DISEASE STRUCTURED TRANSITION EDUCATION INTERVENTION WITH PEER MENTORING SUPPORT TO IMPROVING CARE TRANSITIONS (SCD STEP-UP PROGRAM) awarded by Charlotte-Mecklenburg Hospital Authority 2018 - 2022
- Disseminating NIH Evidence Based Sickle Cell Recommendations in North Carolina awarded by Agency for Healthcare Research and Quality 2016 - 2021
- A Phase 2a, Randomised, Double Blind, Placebo-Controlled Study of IMR-687 in Adult Patients with Sickle Cell Anaemia (Homozygous HbSS or Sickle-B thalassemia. awarded by Imara, Inc. 2019 - 2020
- A Double-blind, Randomized, Placebo-controlled, Multicenter Study of GBT440 Administered Orally to Subjects with Sickle Cell Disease awarded by Global Blood Therapeutics, Inc. 2017 - 2020
- Technology-Mediated Symptom Management in Pediatric Blood and Marrow Transplant Care awarded by National Institutes of Health 2018 - 2020
- Impact of Sickle-Trait on Transcriptional Regulation in P. Falciparum Parasites awarded by National Institutes of Health 2017 - 2020
- AZD9668 and Neutrophil Elastase Inhibition to Prevent Graft-versus-Host Disease awarded by National Institutes of Health 2018 - 2019
- Open Label study to evaluate the safety and Pharmacokinetics of PF-06412528 in children 7-17 for treatment of moderate to severe pain awarded by Pfizer, Inc. 2018 - 2019
- DU176b-A-U157/ A Phase 1, Open-Label, Single-Dose Non-Randomized Study To Evaluate Pharmacokinetics And Pharmacodynamics of Edoxaban In Pediatric Patients awarded by Daiichi Sankyo Inc 2015 - 2019
- SUCCESSOR Chart Review awarded by Novartis Pharmaceuticals Corporation 2018 - 2019
- Use of Mobile Technology to Improve Acute Care Utilization in Sickle Cell Disease awarded by Agency for Healthcare Research and Quality 2015 - 2018
- Multicenter, open-label, active-controlled, randomized study to evaluate the efficacy and safety of an age- and body-weight-adjusted rivaroxaban regimen in children with acute venous thromboembolism awarded by Bayer Healthcare Pharmaceuticals Inc 2015 - 2018
- Improving Pain in Sickle Cell Patients With Targeted Antithrombotic Therapy awarded by National Institutes of Health 2014 - 2017
- Evaluation of Purified Poloxamer 188 in Children in Crisis (EPIC): A Phase 3 randomized, double-blind, placebo-controlled, multicenter clinical trial of MSY-188 injection in children with Sickle Cell disease experiencing vaso-occlusive crisis. awarded by : Mast Therapeutics, Inc. 2014 - 2017
- MST-188-04 EVALUATION OF REPEAT ADMINISTRATION OF PURIFIED POLOXAMER 188 IN VASO-OCCLUSIVE CRISIS OF SICKLE CELL DISEASE (EPIC-E): AN OPEN-LABEL SAFETY EXTENSION TRIAL ASSESSING REPEAT ADMINISTRATION OF MST-188 (PURIFIED POLOXAMER 188) INJECTION IN awarded by : Mast Therapeutics, Inc. 2016 - 2017
- SUSTAIN (A Phase II, Multicenter, Randomized, Placebo-Controlled, Double-Blind, 12-Month Study to Assess Safety and Efficacy of SEIGI With or Without Hydroxyurea Therapy in Sickle Cell Disease Patients with Sickle Cell-Related Pain Crises awarded by Selexys Pharmaceuticals, Corp 2014 - 2017
- QuBBD: Collaborative Research: Advancing mHealth using Big Data Analytics: Statistical and Dynamical Systems Modeling of Real-Time Adaptive m-Intervention for Pain awarded by National Science Foundation 2015 - 2016
- Impact of Daily Prophylaxis Dose Anticoagulation with a Factor Xa Inhibitor (Apixaban) in Patients with Sickle Cell Disease awarded by Bristol-Myers Squibb 2013 - 2016
- Use of Mobile Technology for Intensive Training in Medication Management awarded by Sickle Soft Incorporated 2014 - 2016
- Population-based Surveillance And Outcomes of Venous Thromboembolism awarded by Centers for Disease Control and Prevention 2012 - 2015
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External Relationships
- Alexion
- Bluebird bio
- Emmaus Pharmaceuticals
- Global Blood Therapeutics
- Novartis
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Kroner, Barbara L., Jane S. Hankins, Norma Pugh, Abdullah Kutlar, Allison A. King, Nirmish R. Shah, Julie Kanter, et al. “Pregnancy outcomes with hydroxyurea use in women with sickle cell disease.” Am J Hematol 97, no. 5 (May 2022): 603–12. https://doi.org/10.1002/ajh.26495.Full Text Link to Item
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Treadwell, Marsha J., Swapandeep Mushiana, Sherif M. Badawy, Liliana Preiss, Allison A. King, Barbara Kroner, Yumei Chen, et al. “An evaluation of patient-reported outcomes in sickle cell disease within a conceptual model.” Qual Life Res, April 21, 2022. https://doi.org/10.1007/s11136-022-03132-z.Full Text Link to Item
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Shah, Nirmish, Thokozeni Lipato, Ofelia Alvarez, Thomas Delea, Alexander Lonshteyn, Derek Weycker, Andy Nguyen, Anne Beaubrun, and Irene Agodoa. “Real-world effectiveness of voxelotor for treating sickle cell disease in the US: a large claims data analysis.” Expert Rev Hematol 15, no. 2 (February 2022): 167–73. https://doi.org/10.1080/17474086.2022.2031967.Full Text Link to Item
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Knisely, Mitchell R., Paula J. Tanabe, Julia K. L. Walker, Qing Yang, and Nirmish R. Shah. “Severe Persistent Pain and Inflammatory Biomarkers in Sickle Cell Disease: An Exploratory Study.” Biol Res Nurs 24, no. 1 (January 2022): 24–30. https://doi.org/10.1177/10998004211027220.Full Text Link to Item
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Phillips, Shannon, Yumei Chen, Rita Masese, Laurence Noisette, Kasey Jordan, Sara Jacobs, Lewis L. Hsu, et al. “Perspectives of individuals with sickle cell disease on barriers to care.” Plos One 17, no. 3 (2022): e0265342. https://doi.org/10.1371/journal.pone.0265342.Full Text Link to Item
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Liles, Darla K., Nirmish R. Shah, Brigid Scullin, Victor R. Gordeuk, Wally R. Smith, Julie Kanter, Maureen M. Achebe, et al. “Long-term biological effects in sickle cell disease: insights from a post-crizanlizumab study.” Br J Haematol 195, no. 4 (November 2021): e150–53. https://doi.org/10.1111/bjh.17739.Full Text Link to Item
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Zaidi, Ahmar U., Jeremie Estepp, Nirmish Shah, Salam Alkindi, Hatoon Ezzat, Hung Lam, and Caterina P. Minniti. “A reanalysis of pain crises data from the pivotal l-glutamine in sickle cell disease trial.” Contemp Clin Trials 110 (November 2021): 106546. https://doi.org/10.1016/j.cct.2021.106546.Full Text Link to Item
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Vaughn, Jacqueline, Donruedee Kamkhoad, Shannon Ford, Arvind P. Subramaniam, Saif Khairat, and Nirmish Shah. “An Innovative Undergraduate Interdisciplinary Research Course: Development, Implementation, and Student Perspectives.” Comput Inform Nurs 39, no. 10 (October 1, 2021): 517–23. https://doi.org/10.1097/CIN.0000000000000836.Full Text Link to Item
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Knisely, Mitchell R., Paula J. Tanabe, Qing Yang, Rita Masese, Meilin Jiang, and Nirmish R. Shah. “Severe Pain Profiles and Associated Sociodemographic and Clinical Characteristics in Individuals With Sickle Cell Disease.” Clin J Pain 37, no. 9 (September 1, 2021): 669–77. https://doi.org/10.1097/AJP.0000000000000957.Full Text Link to Item
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Masese, Rita V., Terri DeMartino, Emily Bonnabeau, Ebony N. Burns, Liliana Preiss, Taniya Varughese, Judith M. Nocek, et al. “Effective Recruitment Strategies for a Sickle Cell Patient Registry Across Sites from the Sickle Cell Disease Implementation Consortium (SCDIC).” J Immigr Minor Health 23, no. 4 (August 2021): 725–32. https://doi.org/10.1007/s10903-020-01102-6.Full Text Link to Item
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Vaughn, Jacqueline, Donruedee Kamkhoad, Ryan J. Shaw, Sharron L. Docherty, Arvind P. Subramaniam, and Nirmish Shah. “Seriously ill pediatric patient, parent, and clinician perspectives on visualizing symptom data.” J Am Med Inform Assoc 28, no. 7 (July 14, 2021): 1518–25. https://doi.org/10.1093/jamia/ocab037.Full Text Link to Item
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Vaughn, Jacqueline, Nirmish Shah, Sharron L. Docherty, Qing Yang, and Ryan J. Shaw. “Symptom Monitoring in Children With Life-Threatening Illness: A Feasibility Study Using mHealth.” Ans Adv Nurs Sci 44, no. 3 (July 2021): 268–78. https://doi.org/10.1097/ANS.0000000000000359.Full Text Link to Item
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Badawy, Sherif M., Kaleab Z. Abebe, Charlotte A. Reichman, Grace Checo, Megan E. Hamm, Jennifer Stinson, Chitra Lalloo, et al. “Comparing the Effectiveness of Education Versus Digital Cognitive Behavioral Therapy for Adults With Sickle Cell Disease: Protocol for the Cognitive Behavioral Therapy and Real-time Pain Management Intervention for Sickle Cell via Mobile Applications (CaRISMA) Study.” Jmir Res Protoc 10, no. 5 (May 14, 2021): e29014. https://doi.org/10.2196/29014.Full Text Link to Item
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Shafrin, Jason, Howard H. Z. Thom, Edna Keeney, Daisy M. Gaunt, Lauren M. Zhao, Menaka Bhor, Avery A. Rizio, Lanetta Bronté-Hall, and Nirmish Shah. “The impact of vaso-occlusive crises and disease severity on quality of life and productivity among patients with sickle cell disease in the US.” Curr Med Res Opin 37, no. 5 (May 2021): 761–68. https://doi.org/10.1080/03007995.2021.1897556.Full Text Link to Item
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Casella, James F., Bruce A. Barton, Julie Kanter, L Vandy Black, Suvankar Majumdar, Adlette Inati, Yasser Wali, et al. “Effect of Poloxamer 188 vs Placebo on Painful Vaso-Occlusive Episodes in Children and Adults With Sickle Cell Disease: A Randomized Clinical Trial.” Jama 325, no. 15 (April 20, 2021): 1513–23. https://doi.org/10.1001/jama.2021.3414.Full Text Link to Item
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Shah, Nirmish. “ELIPSIS: developing tools to better understand VOC in SCD.” Blood 137, no. 15 (April 15, 2021): 1987–88. https://doi.org/10.1182/blood.2020009466.Full Text Link to Item
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Crego, Nancy, Rita Masese, Emily Bonnabeau, Christian Douglas, Gary Rains, Nirmish Shah, and Paula Tanabe. “Patient Perspectives of Sickle Cell Management in the Emergency Department.” Crit Care Nurs Q 44, no. 2 (April 2021): 160–74. https://doi.org/10.1097/CNQ.0000000000000350.Full Text Link to Item
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Oyedeji, Charity I., Regina D. Crawford, and Nirmish Shah. “Adherence to Iron Chelation Therapy with Deferasirox Formulations among Patients with Sickle Cell Disease and β-thalassemia.” J Natl Med Assoc 113, no. 2 (April 2021): 170–76. https://doi.org/10.1016/j.jnma.2020.08.007.Full Text Link to Item
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Tanabe, Paula, Audrey L. Blewer, Emily Bonnabeau, Hayden B. Bosworth, Denise H. Clayton, Nancy Crego, Marian F. Earls, et al. “Dissemination of Evidence-Based Recommendations for Sickle Cell Disease to Primary Care and Emergency Department Providers in North Carolina: A Cost Benefit Analysis.” J Health Econ Outcomes Res 8, no. 1 (April 1, 2021): 18–28. https://doi.org/10.36469/jheor.2021.21535.Full Text Link to Item
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Panaggio, Mark J., Daniel M. Abrams, Fan Yang, Tanvi Banerjee, and Nirmish R. Shah. “Can subjective pain be inferred from objective physiological data? Evidence from patients with sickle cell disease.” Plos Comput Biol 17, no. 3 (March 2021): e1008542. https://doi.org/10.1371/journal.pcbi.1008542.Full Text Link to Item
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Royal, Charmaine D. M., Michael Babyak, Nirmish Shah, Shantanu Srivatsa, Kearsley A. Stewart, Paula Tanabe, Ambroise Wonkam, and Monika Asnani. “Sickle cell disease is a global prototype for integrative research and healthcare.” Advanced Genetics 2, no. 1 (March 2021). https://doi.org/10.1002/ggn2.10037.Full Text Open Access Copy
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Stewart, Kearsley A., Monika Parshad-Asnani, Ambroise Wonkam, John Bollinger, Valentina Ngo Bitoungui, Edmond Wonkam-Tingang, Jill Powell, et al. “"Pain is Subjective": A Mixed-Methods Study of Provider Attitudes and Practices Regarding Pain Management in Sickle Cell Disease Across Three Countries.” J Pain Symptom Manage 61, no. 3 (March 2021): 474–87. https://doi.org/10.1016/j.jpainsymman.2020.08.029.Full Text Link to Item
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Racioppi, Alessandro, Tara Dalton, Sendhilnathan Ramalingam, Kristi Romero, Yi Ren, Lauren Bohannon, Consuelo Arellano, et al. “Assessing the Feasibility of a Novel mHealth App in Hematopoietic Stem Cell Transplant Patients.” Transplant Cell Ther 27, no. 2 (February 2021): 181.e1-181.e9. https://doi.org/10.1016/j.jtct.2020.10.017.Full Text Link to Item
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Glaros, Alexander K., Reza Razvi, Nirmish Shah, and Ahmar U. Zaidi. “Voxelotor: alteration of sickle cell disease pathophysiology by a first-in-class polymerization inhibitor.” Ther Adv Hematol 12 (2021): 20406207211001136. https://doi.org/10.1177/20406207211001136.Full Text Link to Item
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Bulgin, Dominique, Emily Bonnabeau, Angie Alexander, Emilia Frederick, Gary Rains, Nirmish Shah, Matthew Young, and Paula Tanabe. “An Interrupted Time Series Analysis of the Dissemination of a Sickle Cell Vaso-Occlusive Episode Treatment Algorithm and a Case Management Referral Form for Individuals With Sickle Cell Disease in the Emergency Department.” J Emerg Nurs 47, no. 1 (January 2021): 40-49.e1. https://doi.org/10.1016/j.jen.2020.06.001.Full Text Link to Item
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Ibemere, Stephanie O., Paula Tanabe, Emily Bonnabeau, Gary Rains, Kern Eason, Marian F. Earls, and Nirmish Shah. “Awareness and Use of the Sickle Cell Disease Toolbox by Primary Care Providers in North Carolina.” J Prim Care Community Health 12 (January 2021): 21501327211049050. https://doi.org/10.1177/21501327211049050.Full Text Link to Item
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Masese, Rita V., Dominique Bulgin, Mitchell R. Knisely, Liliana Preiss, Eleanor Stevenson, Jane S. Hankins, Marsha J. Treadwell, et al. “Sex-based differences in the manifestations and complications of sickle cell disease: Report from the Sickle Cell Disease Implementation Consortium.” Plos One 16, no. 10 (January 2021): e0258638. https://doi.org/10.1371/journal.pone.0258638.Full Text
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Shah, Nirmish R., Menaka Bhor, Dominick Latremouille-Viau, Vikash Kumar Sharma, Gary A. Puckrein, Patrick Gagnon-Sanschagrin, Ankur Khare, et al. “Vaso-occlusive crises and costs of sickle cell disease in patients with commercial, Medicaid, and Medicare insurance - the perspective of private and public payers.” J Med Econ 23, no. 11 (November 2020): 1345–55. https://doi.org/10.1080/13696998.2020.1813144.Full Text Link to Item
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Hankins, Jane S., and Nirmish Shah. “Tackling adherence in sickle cell disease with mHealth.” Lancet Haematol 7, no. 10 (October 2020): e713–14. https://doi.org/10.1016/S2352-3026(20)30299-4.Full Text Link to Item
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Thom, Howard, Jeroen Jansen, Jason Shafrin, Lauren Zhao, George Joseph, Hung-Yuan Cheng, Subhajit Gupta, and Nirmish Shah. “Crizanlizumab and comparators for adults with sickle cell disease: a systematic review and network meta-analysis.” Bmj Open 10, no. 9 (September 17, 2020): e034147. https://doi.org/10.1136/bmjopen-2019-034147.Full Text Link to Item
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Knisely, Mitchell R., Norma Pugh, Barbara Kroner, Rita Masese, Victor Gordeuk, Allison A. King, Sharon M. Smith, et al. “Patient-reported outcomes in sickle cell disease and association with clinical and psychosocial factors: Report from the sickle cell disease implementation consortium.” Am J Hematol 95, no. 9 (September 2020): 1066–74. https://doi.org/10.1002/ajh.25880.Full Text Link to Item
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Hankins, Jane S., Nirmish Shah, Lisa DiMartino, Donald Brambilla, Maria E. Fernandez, Robert W. Gibson, Victor R. Gordeuk, et al. “Integration of Mobile Health Into Sickle Cell Disease Care to Increase Hydroxyurea Utilization: Protocol for an Efficacy and Implementation Study.” Jmir Res Protoc 9, no. 7 (July 14, 2020): e16319. https://doi.org/10.2196/16319.Full Text Link to Item
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Glassberg, Jeffrey A., Elizabeth A. Linton, Katrina Burson, Tabitha Hendershot, Joseph Telfair, Julie Kanter, Victor R. Gordeuk, et al. “Publication of data collection forms from NHLBI funded sickle cell disease implementation consortium (SCDIC) registry.” Orphanet J Rare Dis 15, no. 1 (July 7, 2020): 178. https://doi.org/10.1186/s13023-020-01457-x.Full Text Link to Item
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Lopez Domowicz, Denise A., Ian Welsby, Charles R. Esther, Hongmei Zhu, Robert D. Marek, Grace Lee, Nirmish Shah, Jessica L. Poisson, and Tim J. McMahon. “Effects of repleting organic phosphates in banked erythrocytes on plasma metabolites and vasoactive mediators after red cell exchange transfusion in sickle cell disease.” Blood Transfus 18, no. 3 (May 2020): 200–207. https://doi.org/10.2450/2020.0237-19.Full Text Link to Item
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Crego, Nancy, Christian Douglas, Emily Bonnabeau, Marian Earls, Kern Eason, Elizabeth Merwin, Gary Rains, Paula Tanabe, and Nirmish Shah. “Sickle-Cell Disease Co-Management, Health Care Utilization, and Hydroxyurea Use.” J Am Board Fam Med 33, no. 1 (January 2020): 91–105. https://doi.org/10.3122/jabfm.2020.01.190143.Full Text Link to Item
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Shah, N., M. Bhor, L. Xie, J. Paulose, and H. Yuce. “Medical resource use and costs of treating sickle cell-related vaso-occlusive crisis episodes: A retrospective claims study.” Journal of Health Economics and Outcomes Research 7, no. 1 (January 1, 2020): 52–60. https://doi.org/10.36469/JHEOR.2020.12852.Full Text
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Shah, Nirmish, David Beenhouwer, Michael S. Broder, Lanetta Bronte-Hall, Laura M. De Castro, Sarah N. Gibbs, Victor R. Gordeuk, et al. “Development of a Severity Classification System for Sickle Cell Disease.” Clinicoecon Outcomes Res 12 (2020): 625–33. https://doi.org/10.2147/CEOR.S276121.Full Text Link to Item
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Johnson, Amanda, Fan Yang, Siddharth Gollarahalli, Tanvi Banerjee, Daniel Abrams, Jude Jonassaint, Charles Jonassaint, and Nirmish Shah. “Use of Mobile Health Apps and Wearable Technology to Assess Changes and Predict Pain During Treatment of Acute Pain in Sickle Cell Disease: Feasibility Study.” Jmir Mhealth Uhealth 7, no. 12 (December 2, 2019): e13671. https://doi.org/10.2196/13671.Full Text Link to Item
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Shah, Nirmish, Menaka Bhor, Lin Xie, Rashid Halloway, Steve Arcona, Jincy Paulose, and Huseyin Yuce. “Treatment patterns and economic burden of sickle-cell disease patients prescribed hydroxyurea: a retrospective claims-based study.” Health Qual Life Outcomes 17, no. 1 (October 16, 2019): 155. https://doi.org/10.1186/s12955-019-1225-7.Full Text Link to Item
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Gehrke, Sarah, Nirmish Shah, Fabia Gamboni, Reed Kamyszek, Amudan J. Srinivasan, Alan Gray, Matthew Landrigan, Ian Welsby, and Angelo D’Alessandro. “Metabolic impact of red blood cell exchange with rejuvenated red blood cells in sickle cell patients.” Transfusion 59, no. 10 (October 2019): 3102–12. https://doi.org/10.1111/trf.15467.Full Text Link to Item
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Hart, Laura C., McLean Pollock, Audrey Brown, Nirmish Shah, Richard J. Chung, Richard Sloane, and Gary R. Maslow. “Where Did They Go? Tracking Young Adult Follow-up During the Transition From Pediatric to Adult-Oriented Care.” Clin Pediatr (Phila) 58, no. 11–12 (October 2019): 1277–83. https://doi.org/10.1177/0009922819852980.Full Text Link to Item
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Kamyszek, Reed W., Jay S. Raval, Amudan J. Srinivasan, Andrea K. Ansari, Brooke A. Evans, Marian A. Rollins-Raval, Jessica L. Poisson, Nirmish R. Shah, and Ian J. Welsby. “Interval decline in hemoglobin A is associated with annual clinical event rate in sickle cell anemia patients receiving maintenance apheresis RBC exchange.” Transfusion 59, no. 8 (August 2019): 2622–28. https://doi.org/10.1111/trf.15386.Full Text Link to Item
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Jooste, Edmund H., Rebecca Scholl, Yi-Hung Wu, Robert D. B. Jaquiss, Andrew J. Lodge, Warwick A. Ames, H Mayumi Homi, et al. “Double-Blind, Randomized, Placebo-Controlled Trial Comparing the Effects of Antithrombin Versus Placebo on the Coagulation System in Infants with Low Antithrombin Undergoing Congenital Cardiac Surgery.” J Cardiothorac Vasc Anesth 33, no. 2 (February 2019): 396–402. https://doi.org/10.1053/j.jvca.2018.05.052.Full Text Link to Item
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Masese, Rita Vanessa, Dominique Bulgin, Christian Douglas, Nirmish Shah, and Paula Tanabe. “Barriers and facilitators to care for individuals with sickle cell disease in central North Carolina: The emergency department providers' perspective.” Plos One 14, no. 5 (2019): e0216414. https://doi.org/10.1371/journal.pone.0216414.Full Text Link to Item
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Kayle, Mariam, Sharron L. Docherty, Richard Sloane, Paula Tanabe, Gary Maslow, Wei Pan, and Nirmish Shah. “Transition to adult care in sickle cell disease: A longitudinal study of clinical characteristics and disease severity.” Pediatr Blood Cancer 66, no. 1 (January 2019): e27463. https://doi.org/10.1002/pbc.27463.Full Text Link to Item
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Shah, Nirmish, Menaka Bhor, Lin Xie, Jincy Paulose, and Huseyin Yuce. “Sickle cell disease complications: Prevalence and resource utilization.” Plos One 14, no. 7 (2019): e0214355. https://doi.org/10.1371/journal.pone.0214355.Full Text Link to Item
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Culp-Hill, Rachel, Amudan J. Srinivasan, Sarah Gehrke, Reed Kamyszek, Andrea Ansari, Nirmish Shah, Ian Welsby, and Angelo D’Alessandro. “Effects of red blood cell (RBC) transfusion on sickle cell disease recipient plasma and RBC metabolism.” Transfusion 58, no. 12 (December 2018): 2797–2806. https://doi.org/10.1111/trf.14931.Full Text Link to Item
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DiMartino, Lisa D., Ana A. Baumann, Lewis L. Hsu, Julie Kanter, Victor R. Gordeuk, Jeffrey Glassberg, Marsha J. Treadwell, et al. “The sickle cell disease implementation consortium: Translating evidence-based guidelines into practice for sickle cell disease.” Am J Hematol 93, no. 12 (December 2018): E391–95. https://doi.org/10.1002/ajh.25282.Full Text Link to Item
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Jonassaint, Charles R., Chaeryon Kang, Daniel M. Abrams, Jingyi J. Li, Jason Mao, Yimeng Jia, Qi Long, et al. “Understanding patterns and correlates of daily pain using the Sickle cell disease Mobile Application to Record Symptoms via Technology (SMART).” Br J Haematol 183, no. 2 (October 2018): 306–8. https://doi.org/10.1111/bjh.14956.Full Text Link to Item
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Vaughn, Jacqueline, Jude Jonassaint, Erika Summers-Goeckerman, Ryan J. Shaw, and Nirmish Shah. “Customization of the TRU-PBMT App (Technology Recordings to better Understand Pediatric Blood and Marrow Transplant).” J Pediatr Nurs 42 (September 2018): 86–91. https://doi.org/10.1016/j.pedn.2018.07.007.Full Text Link to Item
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Jonassaint, Charles R., Nema Rao, Alex Sciuto, Galen E. Switzer, Laura De Castro, Gregory J. Kato, Jude C. Jonassaint, Zakia Hammal, Nirmish Shah, and Ajay Wasan. “Abstract Animations for the Communication and Assessment of Pain in Adults: Cross-Sectional Feasibility Study.” J Med Internet Res 20, no. 8 (August 3, 2018): e10056. https://doi.org/10.2196/10056.Full Text Link to Item
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Anderson, Lindsay M., Sarah Leonard, Jude Jonassaint, Joseph Lunyera, Melanie Bonner, and Nirmish Shah. “Mobile health intervention for youth with sickle cell disease: Impact on adherence, disease knowledge, and quality of life.” Pediatr Blood Cancer 65, no. 8 (August 2018): e27081. https://doi.org/10.1002/pbc.27081.Full Text Link to Item
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Badawy, Sherif M., Robert M. Cronin, Jane Hankins, Lori Crosby, Michael DeBaun, Alexis A. Thompson, and Nirmish Shah. “Patient-Centered eHealth Interventions for Children, Adolescents, and Adults With Sickle Cell Disease: Systematic Review.” J Med Internet Res 20, no. 7 (July 19, 2018): e10940. https://doi.org/10.2196/10940.Full Text Link to Item
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Yang, Fan, Tanvi Banerjee, Kalindi Narine, and Nirmish Shah. “Improving Pain Management in Patients with Sickle Cell Disease from Physiological Measures Using Machine Learning Techniques.” Smart Health (Amst) 7–8 (June 2018): 48–59. https://doi.org/10.1016/j.smhl.2018.01.002.Full Text Link to Item
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Sullivan, Keith M., Mitchell Horwitz, Ifeyinwa Osunkwo, Nirmish Shah, and John J. Strouse. “Shared Decision-Making in Hematopoietic Stem Cell Transplantation for Sickle Cell Disease.” Biol Blood Marrow Transplant 24, no. 5 (May 2018): 883–84. https://doi.org/10.1016/j.bbmt.2018.04.001.Full Text Link to Item
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Klein, Nicola P., Tomas Habanec, Pavel Kosina, Nirmish R. Shah, Devayani Kolhe, Jacqueline M. Miller, Marjan Hezareh, and Marie Van der Wielen. “Immunogenicity and safety of the quadrivalent meningococcal ACWY-tetanus toxoid conjugate vaccine (MenACWY-TT) in splenectomized or hyposplenic children and adolescents: Results of a phase III, open, non-randomized study.” Vaccine 36, no. 17 (April 19, 2018): 2356–63. https://doi.org/10.1016/j.vaccine.2018.02.085.Full Text Link to Item
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Sobota, Amy E., Nishita Shah, and Jennifer W. Mack. “Development of quality indicators for transition from pediatric to adult care in sickle cell disease: A modified Delphi survey of adult providers.” Pediatr Blood Cancer 64, no. 6 (June 2017). https://doi.org/10.1002/pbc.26374.Full Text Link to Item
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Leonard, Sarah, Lindsay M. Anderson, Jude Jonassaint, Charles Jonassaint, and Nirmish Shah. “Utilizing a Novel Mobile Health "Selfie" Application to Improve Compliance to Iron Chelation in Pediatric Patients Receiving Chronic Transfusions.” J Pediatr Hematol Oncol 39, no. 3 (April 2017): 223–29. https://doi.org/10.1097/MPH.0000000000000743.Full Text Link to Item
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Lunyera, Joseph, Charles Jonassaint, Jude Jonassaint, and Nirmish Shah. “Attitudes of Primary Care Physicians Toward Sickle Cell Disease Care, Guidelines, and Comanaging Hydroxyurea With a Specialist.” J Prim Care Community Health 8, no. 1 (January 2017): 37–40. https://doi.org/10.1177/2150131916662969.Full Text Link to Item
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Shah, Nirmish R. “Advances in iron chelation therapy: transitioning to a new oral formulation.” Drugs Context 6 (2017): 212502. https://doi.org/10.7573/dic.212502.Full Text Link to Item
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Kayle, Mariam, Paula Tanabe, Nirmish R. Shah, Lynne Baker-Ward, and Sharron L. Docherty. “Challenges in Shifting Management Responsibility From Parents to Adolescents With Sickle Cell Disease.” J Pediatr Nurs 31, no. 6 (November 2016): 678–90. https://doi.org/10.1016/j.pedn.2016.06.008.Full Text Link to Item
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Wang, Hsin-Hsiao Scott, Katherine W. Herbst, Jennifer A. Rothman, Nirmish R. Shah, John S. Wiener, and Jonathan C. Routh. “Trends in Sickle Cell Disease-related Priapism in U.S. Children's Hospitals.” Urology 89 (March 2016): 118–22. https://doi.org/10.1016/j.urology.2015.11.023.Full Text Link to Item
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Goldenberg, N. A., T. Abshire, P. J. Blatchford, L. Z. Fenton, J. L. Halperin, W. R. Hiatt, C. M. Kessler, et al. “Multicenter randomized controlled trial on Duration of Therapy for Thrombosis in Children and Young Adults (the Kids-DOTT trial): pilot/feasibility phase findings.” J Thromb Haemost 13, no. 9 (September 2015): 1597–1605. https://doi.org/10.1111/jth.13038.Full Text Link to Item
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Shah, Nirmish, Ian J. Welsby, Martha A. Fielder, Wayne K. Jacobsen, and Vance G. Nielsen. “Sickle cell disease is associated with iron mediated hypercoagulability.” J Thromb Thrombolysis 40, no. 2 (August 2015): 182–85. https://doi.org/10.1007/s11239-015-1230-6.Full Text Link to Item
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Jonassaint, Charles R., Nirmish Shah, Jude Jonassaint, and Laura De Castro. “Usability and Feasibility of an mHealth Intervention for Monitoring and Managing Pain Symptoms in Sickle Cell Disease: The Sickle Cell Disease Mobile Application to Record Symptoms via Technology (SMART).” Hemoglobin 39, no. 3 (2015): 162–68. https://doi.org/10.3109/03630269.2015.1025141.Full Text Link to Item
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Shah, Nirmish, Margo Rollins, Daniel Landi, Radhika Shah, Jonathan Bae, and Laura M. De Castro. “Differences in pain management between hematologists and hospitalists caring for patients with sickle cell disease hospitalized for vasoocclusive crisis.” Clin J Pain 30, no. 3 (March 2014): 266–68. https://doi.org/10.1097/AJP.0b013e318295ec04.Full Text Link to Item
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Shah, Nirmish, Jude Jonassaint, and Laura De Castro. “Patients welcome the Sickle Cell Disease Mobile Application to Record Symptoms via Technology (SMART).” Hemoglobin 38, no. 2 (2014): 99–103. https://doi.org/10.3109/03630269.2014.880716.Full Text Link to Item
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Landi, Daniel, Michele G. Beckman, Nirmish R. Shah, Paula Bockenstedt, Althea M. Grant, John A. Heit, Nigel S. Key, et al. “Characteristics of abdominal vein thrombosis in children and adults.” Thromb Haemost 109, no. 4 (April 2013): 625–32. https://doi.org/10.1160/TH12-08-0568.Full Text Open Access Copy Link to Item
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Verhovsek, Madeleine, Nirmish R. Shah, Ibifiri Wilcox, Sara C. Koenig, Tiago Barros, Courtney D. Thornburg, Martin H. Steinberg, Hong-yuan Luo, and David H. K. Chui. “Severe fetal and neonatal hemolytic anemia due to a 198 kb deletion removing the complete β-globin gene cluster.” Pediatr Blood Cancer 59, no. 5 (November 2012): 941–44. https://doi.org/10.1002/pbc.24094.Full Text Link to Item
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Shah, Nirmish, Courtney Thornburg, Marilyn J. Telen, and Thomas L. Ortel. “Characterization of the hypercoagulable state in patients with sickle cell disease.” Thromb Res 130, no. 5 (November 2012): e241–45. https://doi.org/10.1016/j.thromres.2012.08.307.Full Text Link to Item
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Shah, Nirmish R., Thomas Ortel, Elizabeth Thames, and Andra H. James. “Changes in Thrombin Generation During Pregnancy as Measured by Computerized Automated Thrombography (Cat).” American Journal of Hematology 87 (May 1, 2012): S170–S170.Link to Item
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Shah, Nirmish, Daniel Landi, Radhika Shah, Jennifer Rothman, Laura M. De Castro, and Courtney D. Thornburg. “Complications of implantable venous access devices in patients with sickle cell disease.” Am J Hematol 87, no. 2 (February 2012): 224–26. https://doi.org/10.1002/ajh.22230.Full Text Open Access Copy Link to Item
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Shah, Nirmish R., Daniel B. Landi, Susan G. Kreissman, Evan Kulbachi, and Cassandra Moran. “Presentation and outcomes for children with bone marrow necrosis and acute lymphoblastic leukemia: a literature review.” J Pediatr Hematol Oncol 33, no. 7 (October 2011): e316–19. https://doi.org/10.1097/MPH.0b013e318223fe9b.Full Text Open Access Copy Link to Item
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Shah, N. R., M. Telen, and T. Ortel. “Evaluation of thrombin generation in sickle cell patients and correlation to clinical disease.” Journal of Thrombosis and Haemostasis 9 (July 1, 2011): 836–836.Link to Item
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Vaughn, Jacqueline, Erika Summers-Goeckerman, Ryan J. Shaw, and Nirmish Shah. “A Protocol to Assess Feasibility, Acceptability, and Usability of Mobile Technology for Symptom Management in Pediatric Transplant Patients.” Nurs Res 68, no. 4 (n.d.): 317–23. https://doi.org/10.1097/NNR.0000000000000343.Full Text Link to Item
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Vaughn, Jacqueline, Nirmish Shah, Jude Jonassaint, Nichol Harris, Sharron Docherty, and Ryan Shaw. “User-Centered App Design for Acutely Ill Children and Adolescents.” J Pediatr Oncol Nurs 37, no. 6 (n.d.): 359–67. https://doi.org/10.1177/1043454220938341.Full Text Link to Item
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Vaughn, Jacqueline, Siddharth Gollarahalli, Ryan J. Shaw, Sharron Docherty, Qing Yang, Chandni Malhotra, Erika Summers-Goeckerman, and Nirmish Shah. “Mobile Health Technology for Pediatric Symptom Monitoring: A Feasibility Study.” Nurs Res 69, no. 2 (n.d.): 142–48. https://doi.org/10.1097/NNR.0000000000000403.Full Text Link to Item
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Badawy, Sherif M., Robert M. Cronin, Jane Hankins, Lori Crosby, Michael DeBaun, Alexis A. Thompson, and Nirmish Shah. “Patient-Centered eHealth Interventions for Children, Adolescents, and Adults With Sickle Cell Disease: Systematic Review (Preprint),” n.d. https://doi.org/10.2196/preprints.10940.Full Text
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Hankins, Jane S., Nirmish Shah, Lisa DiMartino, Donald Brambilla, Maria E. Fernandez, Robert W. Gibson, Victor R. Gordeuk, et al. “Integration of Mobile Health Into Sickle Cell Disease Care to Increase Hydroxyurea Utilization: Protocol for an Efficacy and Implementation Study (Preprint),” n.d. https://doi.org/10.2196/preprints.16319.Full Text
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Jonassaint, Charles, Nema Rao, Alex Sciuto, Galen Switzer, Laura De Castro, Gregory J. Kato, Jude H. Jonassaint, Zakia Hammal, Nirmish Shah, and Ajay Wasan. “A Cross-sectional Feasibility Study Testing the Use of Abstract Animations for the Communication and Assessment of Pain (Preprint),” n.d. https://doi.org/10.2196/preprints.10056.Full Text
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Padhee, Swati, Gary K. Nave Jr, Tanvi Banerjee, Daniel M. Abrams, and Nirmish Shah. “Improving Pain Assessment Using Vital Signs and Pain Medication for Patients With Sickle Cell Disease: Retrospective Study.” Jmir Formative Research 6, no. 6 (n.d.): e36998–e36998. https://doi.org/10.2196/36998.Full Text
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Zaidi, Ahmar Urooj, Nirmish Shah, Ryan Thomas, Muhummad O. Shareef, Bryan Hannan, Arshia Urooj Zaidi, and Michael Urban Callaghan. “SickleFit: Adherence, Feasibility and Validation of Fitbit Charge 3 Metrics in Steady-State Sickle Cell Patients (Preprint),” n.d. https://doi.org/10.2196/preprints.24409.Full Text
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Conference Papers
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Padhee, S., A. Alambo, T. Banerjee, A. Subramaniam, D. M. Abrams, G. K. Nave, and N. Shah. “Pain intensity assessment in sickle cell disease patients using vital signs during hospital visits.” In Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 12662 LNCS:77–85, 2021. https://doi.org/10.1007/978-3-030-68790-8_7.Full Text
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Alambo, A., R. Andrew, S. Gollarahalli, J. Vaughn, T. Banerjee, K. Thirunarayan, D. Abrams, and N. Shah. “Measuring Pain in Sickle Cell Disease using Clinical Text.” In Proceedings of the Annual International Conference of the Ieee Engineering in Medicine and Biology Society, Embs, 2020-July:5838–41, 2020. https://doi.org/10.1109/EMBC44109.2020.9175599.Full Text
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Yang, Fan, Tanvi Banerjee, Mark J. Panaggio, Daniel M. Abrams, and Nirmish R. Shah. “Continuous Pain Assessment Using Ensemble Feature Selection from Wearable Sensor Data.” In Proceedings (Ieee Int Conf Bioinformatics Biomed), 2019:569–76, 2019. https://doi.org/10.1109/bibm47256.2019.8983282.Full Text Link to Item
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Clifton, Sara M., Chaeryon Kang, Jingyi Jessica Li, Qi Long, Nirmish Shah, and Daniel M. Abrams. “Hybrid Statistical and Mechanistic Mathematical Model Guides Mobile Health Intervention for Chronic Pain.” In J Comput Biol, 24:675–88, 2017. https://doi.org/10.1089/cmb.2017.0059.Full Text Link to Item
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Preprints
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Padhee, Swati, Gary K. Nave Jr, Tanvi Banerjee, Daniel M. Abrams, and Nirmish Shah. “Pain Assessment using Vital Signs and Pain Medication for patients with Sickle Cell Disease: Retrospective Study (Preprint).” JMIR Publications Inc., n.d. https://doi.org/10.2196/preprints.36998.Full Text
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- Scholarly, Clinical, & Service Activities
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Outreach & Engaged Scholarship
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