Nirmish Ramesh Shah
Assistant Professor of Medicine
Current Appointments & Affiliations
- Assistant Professor of Medicine, Medicine, Hematology, Medicine 2012
- Assistant Professor in Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2012
Contact Information
- Department Of Medicine, Duke S, Durham, NC 27710
- Department Of Medicine, Duke S, Durham, NC 27710
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nirmish.shah@duke.edu
(919) 668-5178
- Background
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Education, Training, & Certifications
- Fellowship, Pediatric Hematology/ Oncology, Duke University School of Medicine 2007 - 2010
- Fellowship, Adult Hematology/Oncology, East Carolina University 2004 - 2005
- Resident, Medicine Pediatrics, East Carolina University 2000 - 2004
- M.D., American University of the Caribbean 2000
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Duke Appointment History
- Medical Instructor in the Department of Medicine, Medicine, Hematology, Medicine 2010 - 2012
- Medical Instructor in the Department of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2010 - 2012
- Instructor Temporary in the Department of Medicine, Medicine, Hematology, Medicine 2010
- Expertise
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Subject Headings
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Global Scholarship
- Research
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Selected Grants
- Improving SCD Care using Web-based Guidelines, Nurse Care Managers and Peer Mentors in Parimary Care Emergency Departments in Central North Carolina awarded by National Institutes of Health 2016 - 2022
- GBT 440-034 awarded by Global Blood Therapeutics, Inc. 2018 - 2022
- A Double-blind, Randomized, Placebo-controlled, Multicenter Study of GBT440 Administered Orally to Subjects with Sickle Cell Disease awarded by Global Blood Therapeutics, Inc. 2017 - 2022
- Phase II study to assess SEG101 in Sickle Cell Patients awarded by Novartis Pharmaceuticals Corporation 2018 - 2022
- Technology-Mediated Symptom Management in Pediatric Blood and Marrow Transplant Care awarded by National Institutes of Health 2018 - 2021
- Transfusion Medicine and Hematology awarded by National Institutes of Health 1975 - 2021
- Open Label study to evaluate the safety and Pharmacokinetics of PF-06412528 in children 7-17 for treatment of moderate to severe pain awarded by Pfizer, Inc. 2018 - 2021
- Disseminating NIH Evidence Based Sickle Cell Recommendations in North Carolina awarded by Agency for Healthcare Research and Quality 2016 - 2020
- Impact of Sickle-Trait on Transcriptional Regulation in P. Falciparum Parasites awarded by National Institutes of Health 2017 - 2020
- DU176b-A-U157/ A Phase 1, Open-Label, Single-Dose Non-Randomized Study To Evaluate Pharmacokinetics And Pharmacodynamics of Edoxaban In Pediatric Patients awarded by Daiichi Sankyo Inc 2015 - 2019
- AZD9668 and Neutrophil Elastase Inhibition to Prevent Graft-versus-Host Disease awarded by National Institutes of Health 2018 - 2019
- SCH: INT: Collaborative Research: Development and analysis of integrative models for chronic pain awarded by Northwestern University 2018 - 2019
- SUCCESSOR Chart Review awarded by Novartis Pharmaceuticals Corporation 2018 - 2019
- SICKLE CELL DISEASE STRUCTURED TRANSITION EDUCATION INTERVENTION WITH PEER MENTORING SUPPORT TO IMPROVING CARE TRANSITIONS (SCD STEP-UP PROGRAM) awarded by Charlotte-Mecklenburg Hospital Authority 2018 - 2019
- Use of Mobile Technology to Improve Acute Care Utilization in Sickle Cell Disease awarded by Agency for Healthcare Research and Quality 2015 - 2018
- EINSTEIN Junior Phase III: oral rivaroxaban in children with venous thrombosis awarded by Bayer Healthcare Pharmaceuticals Inc 2015 - 2018
- Improving Pain in Sickle Cell Patients With Targeted Antithrombotic Therapy awarded by National Institutes of Health 2014 - 2017
- EPIC: Evaluation of purified poloxamer 188 in children in crisis awarded by : Mast Therapeutics, Inc. 2014 - 2017
- EVALUATION OF REPEAT ADMINISTRATION OF PURIFIED POLOXAMER 188 IN VASO-OCCLUSIVE CRISIS OF SICKLE CELL DISEASE (EPIC-E): AN OPEN-LABEL SAFETY EXTENSION TRIAL ASSESSING REPEAT ADMINISTRATION OF MST-188 awarded by : Mast Therapeutics, Inc. 2016 - 2017
- SUSTAIN awarded by Selexys Pharmaceuticals, Corp 2014 - 2017
- QuBBD: Collaborative Research: Advancing mHealth using Big Data Analytics: Statistical and Dynamical Systems Modeling of Real-Time Adaptive m-Intervention for Pain awarded by National Science Foundation 2015 - 2016
- Apixaban SC awarded by Bristol-Myers Squibb 2013 - 2016
- Use of Mobile Technology for Intensive Training in Medication Management awarded by Sickle Soft Incorporated 2014 - 2016
- Population-based Surveillance And Outcomes of Venous Thromboembolism awarded by Centers for Disease Control and Prevention 2012 - 2015
- Publications & Artistic Works
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Selected Publications
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Academic Articles
- Jooste, EH, Scholl, R, Wu, Y-H, Jaquiss, RDB, Lodge, AJ, Ames, WA, Homi, HM, Machovec, KA, Greene, NH, Donahue, BS, Shah, N, and Benkwitz, C. "Double-Blind, Randomized, Placebo-Controlled Trial Comparing the Effects of Antithrombin Versus Placebo on the Coagulation System in Infants with Low Antithrombin Undergoing Congenital Cardiac Surgery." Journal of Cardiothoracic and Vascular Anesthesia 33, no. 2 (February 2019): 396-402. Full Text
- Kayle, M, Docherty, SL, Sloane, R, Tanabe, P, Maslow, G, Pan, W, and Shah, N. "Transition to adult care in sickle cell disease: A longitudinal study of clinical characteristics and disease severity." Pediatric Blood & Cancer 66, no. 1 (January 2019): e27463-null. Full Text
- Culp-Hill, R, Srinivasan, AJ, Gehrke, S, Kamyszek, R, Ansari, A, Shah, N, Welsby, I, and D'Alessandro, A. "Effects of red blood cell (RBC) transfusion on sickle cell disease recipient plasma and RBC metabolism." Transfusion 58, no. 12 (December 1, 2018): 2797-2806. Full Text
- DiMartino, LD, Baumann, AA, Hsu, LL, Kanter, J, Gordeuk, VR, Glassberg, J, Treadwell, MJ, Melvin, CL, Telfair, J, Klesges, LM, King, A, Wun, T, Shah, N, Gibson, RW, Hankins, JS, and Sickle Cell Disease Implementation Consortium, . "The sickle cell disease implementation consortium: Translating evidence-based guidelines into practice for sickle cell disease." American Journal of Hematology 93, no. 12 (December 2018): E391-E395. (Letter) Full Text
- Jonassaint, CR, Kang, C, Abrams, DM, Li, JJ, Mao, J, Jia, Y, Long, Q, Sanger, M, Jonassaint, JC, De Castro, L, and Shah, N. "Understanding patterns and correlates of daily pain using the Sickle cell disease Mobile Application to Record Symptoms via Technology (SMART)." British Journal of Haematology 183, no. 2 (October 2018): 306-308. (Letter) Full Text
- Vaughn, J, Jonassaint, J, Summers-Goeckerman, E, Shaw, RJ, and Shah, N. "Customization of the TRU-PBMT App (Technology Recordings to better Understand Pediatric Blood and Marrow Transplant)." Journal of Pediatric Nursing 42 (September 2018): 86-91. Full Text
- Anderson, LM, Leonard, S, Jonassaint, J, Lunyera, J, Bonner, M, and Shah, N. "Mobile health intervention for youth with sickle cell disease: Impact on adherence, disease knowledge, and quality of life." Pediatric Blood and Cancer 65, no. 8 (August 1, 2018). Full Text
- Jonassaint, CR, Rao, N, Sciuto, A, Switzer, GE, De Castro, L, Kato, GJ, Jonassaint, JC, Hammal, Z, Shah, N, and Wasan, A. "Abstract animations for the communication and assessment of pain in adults: Cross-sectional feasibility study." Journal of Medical Internet Research 20, no. 8 (August 1, 2018). Full Text
- Badawy, SM, Cronin, RM, Hankins, J, Crosby, L, DeBaun, M, Thompson, AA, and Shah, N. "Patient-centered eHealth interventions for children, adolescents, and adults with sickle cell disease: Systematic review." Journal of Medical Internet Research 20, no. 7 (July 1, 2018). (Review) Full Text
- Yang, F, Banerjee, T, Narine, K, and Shah, N. "Improving pain management in patients with sickle cell disease from physiological measures using machine learning techniques." Smart Health 7-8 (June 1, 2018): 48-59. Full Text
- Sullivan, KM, Horwitz, M, Osunkwo, I, Shah, N, and Strouse, JJ. "Shared Decision-Making in Hematopoietic Stem Cell Transplantation for Sickle Cell Disease." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 24, no. 5 (May 2018): 883-884. Full Text
- Klein, NP, Habanec, T, Kosina, P, Shah, NR, Kolhe, D, Miller, JM, Hezareh, M, and Van der Wielen, M. "Immunogenicity and safety of the quadrivalent meningococcal ACWY-tetanus toxoid conjugate vaccine (MenACWY-TT) in splenectomized or hyposplenic children and adolescents: Results of a phase III, open, non-randomized study." Vaccine 36, no. 17 (April 2018): 2356-2363. Full Text
- Sobota, AE, Shah, N, and Mack, JW. "Development of quality indicators for transition from pediatric to adult care in sickle cell disease: A modified Delphi survey of adult providers." Pediatric Blood & Cancer 64, no. 6 (June 2017). Full Text
- Leonard, S, Anderson, LM, Jonassaint, J, Jonassaint, C, and Shah, N. "Utilizing a Novel Mobile Health "Selfie" Application to Improve Compliance to Iron Chelation in Pediatric Patients Receiving Chronic Transfusions." Journal of Pediatric Hematology/Oncology 39, no. 3 (April 2017): 223-229. Full Text
- Lunyera, J, Jonassaint, C, Jonassaint, J, and Shah, N. "Attitudes of Primary Care Physicians Toward Sickle Cell Disease Care, Guidelines, and Comanaging Hydroxyurea With a Specialist." Journal of Primary Care & Community Health 8, no. 1 (January 2017): 37-40. Full Text
- Shah, NR. "Advances in iron chelation therapy: transitioning to a new oral formulation." Drugs in context 6 (January 2017): 212502-. Full Text
- Kayle, M, Tanabe, P, Shah, NR, Baker-Ward, L, and Docherty, SL. "Challenges in Shifting Management Responsibility From Parents to Adolescents With Sickle Cell Disease." Journal of pediatric nursing 31, no. 6 (November 2016): 678-690. Full Text
- Wang, H-HS, Herbst, KW, Rothman, JA, Shah, NR, Wiener, JS, and Routh, JC. "Trends in Sickle Cell Disease-related Priapism in U.S. Children's Hospitals." Urology 89 (March 2016): 118-122. Full Text
- Goldenberg, NA, Abshire, T, Blatchford, PJ, Fenton, LZ, Halperin, JL, Hiatt, WR, Kessler, CM, Kittelson, JM, Manco-Johnson, MJ, Spyropoulos, AC, Steg, PG, Stence, NV, Turpie, AGG, Schulman, S, and Kids-DOTT Trial Investigators, . "Multicenter randomized controlled trial on Duration of Therapy for Thrombosis in Children and Young Adults (the Kids-DOTT trial): pilot/feasibility phase findings." Journal of Thrombosis and Haemostasis : Jth 13, no. 9 (September 2015): 1597-1605. Full Text
- Shah, N, Welsby, IJ, Fielder, MA, Jacobsen, WK, and Nielsen, VG. "Sickle cell disease is associated with iron mediated hypercoagulability." Journal of thrombosis and thrombolysis 40, no. 2 (August 2015): 182-185. Full Text
- Jonassaint, CR, Shah, N, Jonassaint, J, and De Castro, L. "Usability and Feasibility of an mHealth Intervention for Monitoring and Managing Pain Symptoms in Sickle Cell Disease: The Sickle Cell Disease Mobile Application to Record Symptoms via Technology (SMART)." Hemoglobin 39, no. 3 (January 2015): 162-168. Full Text
- Shah, N, Rollins, M, Landi, D, Shah, R, Bae, J, and De Castro, LM. "Differences in pain management between hematologists and hospitalists caring for patients with sickle cell disease hospitalized for vasoocclusive crisis." The Clinical Journal of Pain 30, no. 3 (March 2014): 266-268. Full Text
- Shah, N, Jonassaint, J, and De Castro, L. "Patients welcome the Sickle Cell Disease Mobile Application to Record Symptoms via Technology (SMART)." Hemoglobin 38, no. 2 (January 2014): 99-103. Full Text
- Shah, N, Rollins, M, Landi, D, Shah, R, Bae, J, and Castro, LMD. "Differences in pain management between hematologists and hospitalists caring for patients with sickle cell disease hospitalized for vasoocclusive crisis." Clinical Journal of Pain 30, no. 3 (2014): 266-268. Full Text
- Landi, D, Beckman, MG, Shah, NR, Bockenstedt, P, Grant, AM, Heit, JA, Key, NS, Kulkarni, R, Manco-Johnson, M, Moll, S, Philipp, CS, Andersen, JC, and Ortel, TL. "Characteristics of abdominal vein thrombosis in children and adults." Thrombosis and Haemostasis 109, no. 4 (April 2013): 625-632. Full Text
- Shah, N, Thornburg, C, Telen, MJ, and Ortel, TL. "Characterization of the hypercoagulable state in patients with sickle cell disease." Thrombosis Research 130, no. 5 (November 2012): e241-e245. Full Text
- Verhovsek, M, Shah, NR, Wilcox, I, Koenig, SC, Barros, T, Thornburg, CD, Steinberg, MH, Luo, H-Y, and Chui, DHK. "Severe fetal and neonatal hemolytic anemia due to a 198 kb deletion removing the complete β-globin gene cluster." Pediatr Blood Cancer 59, no. 5 (November 2012): 941-944. Full Text Link to Item
- Shah, NR, Ortel, T, Thames, E, and James, AH. "Changes in Thrombin Generation During Pregnancy as Measured by Computerized Automated Thrombography (Cat)." AMERICAN JOURNAL OF HEMATOLOGY 87 (May 2012): S170-S170. Link to Item
- Shah, N, Landi, D, Shah, R, Rothman, J, De Castro, LM, and Thornburg, CD. "Complications of implantable venous access devices in patients with sickle cell disease." American Journal of Hematology 87, no. 2 (February 2012): 224-226. Full Text
- Shah, NR, Landi, DB, Kreissman, SG, Kulbachi, E, and Moran, C. "Presentation and outcomes for children with bone marrow necrosis and acute lymphoblastic leukemia: a literature review." J Pediatr Hematol Oncol 33, no. 7 (October 2011): e316-e319. (Review) Full Text Link to Item
- Shah, NR, Telen, M, and Ortel, T. "Evaluation of thrombin generation in sickle cell patients and correlation to clinical disease." JOURNAL OF THROMBOSIS AND HAEMOSTASIS 9 (July 2011): 836-836. Link to Item
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Conference Papers
- Clifton, SM, Kang, C, Li, JJ, Long, Q, Shah, N, and Abrams, DM. "Hybrid Statistical and Mechanistic Mathematical Model Guides Mobile Health Intervention for Chronic Pain." July 2017. Full Text
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- Scholarly, Clinical, & Service Activities
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Outreach & Engaged Scholarship
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