Nirmish Ramesh Shah | Scholars@Duke

Nirmish Ramesh Shah
Associate Professor of Medicine

Current Appointments & Affiliations

Associate Professor of Medicine, Medicine, Hematology, Medicine 2019
Associate Professor in Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2019
Associate Professor in the School of Nursing, School of Nursing, Duke University 2019

Contact Information

Department of Medicine, Duke S, Durham, NC 27710
Department of Medicine, Duke S, Durham, NC 27710
nirmish.shah@duke.edu (919) 668-5178

Background
Education, Training, & Certifications
- Fellowship, Pediatric Hematology/ Oncology, Duke University School of Medicine 2007 - 2010
- Fellowship, Adult Hematology/Oncology, East Carolina University 2004 - 2005
- Resident, Medicine Pediatrics, East Carolina University 2000 - 2004
- M.D., American University of the Caribbean 2000
Duke Appointment History
- Assistant Professor in Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2012 - 2019
- Assistant Professor of Medicine, Medicine, Hematology, Medicine 2012 - 2019
- Medical Instructor in the Department of Medicine, Medicine, Hematology, Medicine 2010 - 2012
- Medical Instructor in the Department of Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2010 - 2012
- Instructor Temporary in the Department of Medicine, Medicine, Hematology, Medicine 2010
Expertise
Subject Headings
Global Scholarship
- Research
Research
Selected Grants
External Relationships
- Alexion
- Bluebird bio
- CSL Behring AG
- Global Blood Therapeutics
- Novartis
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Masese, Rita V., Terri DeMartino, Emily Bonnabeau, Ebony N. Burns, Liliana Preiss, Taniya Varughese, Judith M. Nocek, et al. “Effective Recruitment Strategies for a Sickle Cell Patient Registry Across Sites from the Sickle Cell Disease Implementation Consortium (SCDIC).” J Immigr Minor Health, October 9, 2020. https://doi.org/10.1007/s10903-020-01102-6.
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  - Hankins, Jane S., and Nirmish Shah. “Tackling adherence in sickle cell disease with mHealth.” Lancet Haematol 7, no. 10 (October 2020): e713–14. https://doi.org/10.1016/S2352-3026(20)30299-4.
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  - Thom, Howard, Jeroen Jansen, Jason Shafrin, Lauren Zhao, George Joseph, Hung-Yuan Cheng, Subhajit Gupta, and Nirmish Shah. “Crizanlizumab and comparators for adults with sickle cell disease: a systematic review and network meta-analysis.” Bmj Open 10, no. 9 (September 17, 2020): e034147. https://doi.org/10.1136/bmjopen-2019-034147.
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  - Shah, Nirmish R., Menaka Bhor, Dominick Latremouille-Viau, Vikash Kumar Sharma, Gary A. Puckrein, Patrick Gagnon-Sanschagrin, Ankur Khare, et al. “Vaso-occlusive crises and costs of sickle cell disease in patients with commercial, Medicaid, and Medicare insurance - the perspective of private and public payers.” J Med Econ, September 9, 2020, 1–11. https://doi.org/10.1080/13696998.2020.1813144.
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  - Oyedeji, Charity I., Regina D. Crawford, and Nirmish Shah. “Adherence to Iron Chelation Therapy with Deferasirox Formulations among Patients with Sickle Cell Disease and β-thalassemia.” J Natl Med Assoc, September 3, 2020. https://doi.org/10.1016/j.jnma.2020.08.007.
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  - Glassberg, Jeffrey A., Elizabeth A. Linton, Katrina Burson, Tabitha Hendershot, Joseph Telfair, Julie Kanter, Victor R. Gordeuk, et al. “Publication of data collection forms from NHLBI funded sickle cell disease implementation consortium (SCDIC) registry.” Orphanet J Rare Dis 15, no. 1 (July 7, 2020): 178. https://doi.org/10.1186/s13023-020-01457-x.
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  - Hankins, J. S., N. Shah, L. DiMartino, D. Brambilla, M. E. Fernandez, R. W. Gibson, V. R. Gordeuk, et al. “Integration of mobile health into sickle cell disease care to increase hydroxyurea utilization: Protocol for an efficacy and implementation study.” Jmir Research Protocols 9, no. 7 (July 1, 2020). https://doi.org/10.2196/16319.
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  - Knisely, Mitchell R., Norma Pugh, Barbara Kroner, Rita Masese, Victor Gordeuk, Allison A. King, Sharon M. Smith, et al. “Patient-reported outcomes in sickle cell disease and association with clinical and psychosocial factors: Report from the sickle cell disease implementation consortium.” Am J Hematol, May 25, 2020. https://doi.org/10.1002/ajh.25880.
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  - Lopez Domowicz, Denise A., Ian Welsby, Charles R. Esther, Hongmei Zhu, Robert D. Marek, Grace Lee, Nirmish Shah, Jessica L. Poisson, and Tim J. McMahon. “Effects of repleting organic phosphates in banked erythrocytes on plasma metabolites and vasoactive mediators after red cell exchange transfusion in sickle cell disease.” Blood Transfus 18, no. 3 (May 2020): 200–207. https://doi.org/10.2450/2020.0237-19.
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  - Bulgin, D., E. Bonnabeau, A. Alexander, E. Frederick, G. Rains, N. Shah, M. Young, and P. Tanabe. “An Interrupted Time Series Analysis of the Dissemination of a Sickle Cell Vaso-Occlusive Episode Treatment Algorithm and a Case Management Referral Form for Individuals With Sickle Cell Disease in the Emergency Department.” Journal of Emergency Nursing, January 1, 2020. https://doi.org/10.1016/j.jen.2020.06.001.
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  - Crego, Nancy, Christian Douglas, Emily Bonnabeau, Marian Earls, Kern Eason, Elizabeth Merwin, Gary Rains, Paula Tanabe, and Nirmish Shah. “Sickle-Cell Disease Co-Management, Health Care Utilization, and Hydroxyurea Use.” J Am Board Fam Med 33, no. 1 (January 2020): 91–105. https://doi.org/10.3122/jabfm.2020.01.190143.
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  - Johnson, Amanda, Fan Yang, Siddharth Gollarahalli, Tanvi Banerjee, Daniel Abrams, Jude Jonassaint, Charles Jonassaint, and Nirmish Shah. “Use of Mobile Health Apps and Wearable Technology to Assess Changes and Predict Pain During Treatment of Acute Pain in Sickle Cell Disease: Feasibility Study.” Jmir Mhealth Uhealth 7, no. 12 (December 2, 2019): e13671. https://doi.org/10.2196/13671.
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  - Shah, Nirmish, Menaka Bhor, Lin Xie, Rashid Halloway, Steve Arcona, Jincy Paulose, and Huseyin Yuce. “Treatment patterns and economic burden of sickle-cell disease patients prescribed hydroxyurea: a retrospective claims-based study.” Health Qual Life Outcomes 17, no. 1 (October 16, 2019): 155. https://doi.org/10.1186/s12955-019-1225-7.
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  - Gehrke, Sarah, Nirmish Shah, Fabia Gamboni, Reed Kamyszek, Amudan J. Srinivasan, Alan Gray, Matthew Landrigan, Ian Welsby, and Angelo D’Alessandro. “Metabolic impact of red blood cell exchange with rejuvenated red blood cells in sickle cell patients.” Transfusion 59, no. 10 (October 2019): 3102–12. https://doi.org/10.1111/trf.15467.
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  - Hart, Laura C., McLean Pollock, Audrey Brown, Nirmish Shah, Richard J. Chung, Richard Sloane, and Gary R. Maslow. “Where Did They Go? Tracking Young Adult Follow-up During the Transition From Pediatric to Adult-Oriented Care.” Clin Pediatr (Phila) 58, no. 11–12 (October 2019): 1277–83. https://doi.org/10.1177/0009922819852980.
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  - Kamyszek, Reed W., Jay S. Raval, Amudan J. Srinivasan, Andrea K. Ansari, Brooke A. Evans, Marian A. Rollins-Raval, Jessica L. Poisson, Nirmish R. Shah, and Ian J. Welsby. “Interval decline in hemoglobin A is associated with annual clinical event rate in sickle cell anemia patients receiving maintenance apheresis RBC exchange.” Transfusion 59, no. 8 (August 2019): 2622–28. https://doi.org/10.1111/trf.15386.
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  - Jooste, Edmund H., Rebecca Scholl, Yi-Hung Wu, Robert D. B. Jaquiss, Andrew J. Lodge, Warwick A. Ames, H Mayumi Homi, et al. “Double-Blind, Randomized, Placebo-Controlled Trial Comparing the Effects of Antithrombin Versus Placebo on the Coagulation System in Infants with Low Antithrombin Undergoing Congenital Cardiac Surgery.” J Cardiothorac Vasc Anesth 33, no. 2 (February 2019): 396–402. https://doi.org/10.1053/j.jvca.2018.05.052.
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  - Kayle, Mariam, Sharron L. Docherty, Richard Sloane, Paula Tanabe, Gary Maslow, Wei Pan, and Nirmish Shah. “Transition to adult care in sickle cell disease: A longitudinal study of clinical characteristics and disease severity.” Pediatr Blood Cancer 66, no. 1 (January 2019): e27463. https://doi.org/10.1002/pbc.27463.
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  - Masese, Rita Vanessa, Dominique Bulgin, Christian Douglas, Nirmish Shah, and Paula Tanabe. “Barriers and facilitators to care for individuals with sickle cell disease in central North Carolina: The emergency department providers' perspective.” Plos One 14, no. 5 (2019): e0216414. https://doi.org/10.1371/journal.pone.0216414.
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  - Shah, Nirmish, Menaka Bhor, Lin Xie, Jincy Paulose, and Huseyin Yuce. “Sickle cell disease complications: Prevalence and resource utilization.” Plos One 14, no. 7 (2019): e0214355. https://doi.org/10.1371/journal.pone.0214355.
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  - Culp-Hill, Rachel, Amudan J. Srinivasan, Sarah Gehrke, Reed Kamyszek, Andrea Ansari, Nirmish Shah, Ian Welsby, and Angelo D’Alessandro. “Effects of red blood cell (RBC) transfusion on sickle cell disease recipient plasma and RBC metabolism.” Transfusion 58, no. 12 (December 2018): 2797–2806. https://doi.org/10.1111/trf.14931.
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  - DiMartino, Lisa D., Ana A. Baumann, Lewis L. Hsu, Julie Kanter, Victor R. Gordeuk, Jeffrey Glassberg, Marsha J. Treadwell, et al. “The sickle cell disease implementation consortium: Translating evidence-based guidelines into practice for sickle cell disease.” Am J Hematol 93, no. 12 (December 2018): E391–95. https://doi.org/10.1002/ajh.25282.
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  - Jonassaint, Charles R., Chaeryon Kang, Daniel M. Abrams, Jingyi J. Li, Jason Mao, Yimeng Jia, Qi Long, et al. “Understanding patterns and correlates of daily pain using the Sickle cell disease Mobile Application to Record Symptoms via Technology (SMART).” Br J Haematol 183, no. 2 (October 2018): 306–8. https://doi.org/10.1111/bjh.14956.
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  - Vaughn, Jacqueline, Jude Jonassaint, Erika Summers-Goeckerman, Ryan J. Shaw, and Nirmish Shah. “Customization of the TRU-PBMT App (Technology Recordings to better Understand Pediatric Blood and Marrow Transplant).” J Pediatr Nurs 42 (September 2018): 86–91. https://doi.org/10.1016/j.pedn.2018.07.007.
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  - Jonassaint, Charles R., Nema Rao, Alex Sciuto, Galen E. Switzer, Laura De Castro, Gregory J. Kato, Jude C. Jonassaint, Zakia Hammal, Nirmish Shah, and Ajay Wasan. “Abstract Animations for the Communication and Assessment of Pain in Adults: Cross-Sectional Feasibility Study.” J Med Internet Res 20, no. 8 (August 3, 2018): e10056. https://doi.org/10.2196/10056.
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  - Anderson, Lindsay M., Sarah Leonard, Jude Jonassaint, Joseph Lunyera, Melanie Bonner, and Nirmish Shah. “Mobile health intervention for youth with sickle cell disease: Impact on adherence, disease knowledge, and quality of life.” Pediatr Blood Cancer 65, no. 8 (August 2018): e27081. https://doi.org/10.1002/pbc.27081.
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  - Badawy, Sherif M., Robert M. Cronin, Jane Hankins, Lori Crosby, Michael DeBaun, Alexis A. Thompson, and Nirmish Shah. “Patient-Centered eHealth Interventions for Children, Adolescents, and Adults With Sickle Cell Disease: Systematic Review.” J Med Internet Res 20, no. 7 (July 19, 2018): e10940. https://doi.org/10.2196/10940.
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  - Yang, Fan, Tanvi Banerjee, Kalindi Narine, and Nirmish Shah. “Improving Pain Management in Patients with Sickle Cell Disease from Physiological Measures Using Machine Learning Techniques.” Smart Health (Amst) 7–8 (June 2018): 48–59. https://doi.org/10.1016/j.smhl.2018.01.002.
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  - Sullivan, Keith M., Mitchell Horwitz, Ifeyinwa Osunkwo, Nirmish Shah, and John J. Strouse. “Shared Decision-Making in Hematopoietic Stem Cell Transplantation for Sickle Cell Disease.” Biol Blood Marrow Transplant 24, no. 5 (May 2018): 883–84. https://doi.org/10.1016/j.bbmt.2018.04.001.
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  - Klein, Nicola P., Tomas Habanec, Pavel Kosina, Nirmish R. Shah, Devayani Kolhe, Jacqueline M. Miller, Marjan Hezareh, and Marie Van der Wielen. “Immunogenicity and safety of the quadrivalent meningococcal ACWY-tetanus toxoid conjugate vaccine (MenACWY-TT) in splenectomized or hyposplenic children and adolescents: Results of a phase III, open, non-randomized study.” Vaccine 36, no. 17 (April 19, 2018): 2356–63. https://doi.org/10.1016/j.vaccine.2018.02.085.
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  - Sobota, Amy E., Nishita Shah, and Jennifer W. Mack. “Development of quality indicators for transition from pediatric to adult care in sickle cell disease: A modified Delphi survey of adult providers.” Pediatr Blood Cancer 64, no. 6 (June 2017). https://doi.org/10.1002/pbc.26374.
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  - Leonard, Sarah, Lindsay M. Anderson, Jude Jonassaint, Charles Jonassaint, and Nirmish Shah. “Utilizing a Novel Mobile Health "Selfie" Application to Improve Compliance to Iron Chelation in Pediatric Patients Receiving Chronic Transfusions.” J Pediatr Hematol Oncol 39, no. 3 (April 2017): 223–29. https://doi.org/10.1097/MPH.0000000000000743.
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  - Lunyera, Joseph, Charles Jonassaint, Jude Jonassaint, and Nirmish Shah. “Attitudes of Primary Care Physicians Toward Sickle Cell Disease Care, Guidelines, and Comanaging Hydroxyurea With a Specialist.” J Prim Care Community Health 8, no. 1 (January 2017): 37–40. https://doi.org/10.1177/2150131916662969.
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  - Shah, Nirmish R. “Advances in iron chelation therapy: transitioning to a new oral formulation.” Drugs Context 6 (2017): 212502. https://doi.org/10.7573/dic.212502.
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  - Kayle, Mariam, Paula Tanabe, Nirmish R. Shah, Lynne Baker-Ward, and Sharron L. Docherty. “Challenges in Shifting Management Responsibility From Parents to Adolescents With Sickle Cell Disease.” J Pediatr Nurs 31, no. 6 (November 2016): 678–90. https://doi.org/10.1016/j.pedn.2016.06.008.
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  - Wang, Hsin-Hsiao Scott, Katherine W. Herbst, Jennifer A. Rothman, Nirmish R. Shah, John S. Wiener, and Jonathan C. Routh. “Trends in Sickle Cell Disease-related Priapism in U.S. Children's Hospitals.” Urology 89 (March 2016): 118–22. https://doi.org/10.1016/j.urology.2015.11.023.
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  - Goldenberg, N. A., T. Abshire, P. J. Blatchford, L. Z. Fenton, J. L. Halperin, W. R. Hiatt, C. M. Kessler, et al. “Multicenter randomized controlled trial on Duration of Therapy for Thrombosis in Children and Young Adults (the Kids-DOTT trial): pilot/feasibility phase findings.” J Thromb Haemost 13, no. 9 (September 2015): 1597–1605. https://doi.org/10.1111/jth.13038.
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  - Shah, Nirmish, Ian J. Welsby, Martha A. Fielder, Wayne K. Jacobsen, and Vance G. Nielsen. “Sickle cell disease is associated with iron mediated hypercoagulability.” J Thromb Thrombolysis 40, no. 2 (August 2015): 182–85. https://doi.org/10.1007/s11239-015-1230-6.
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  - Jonassaint, Charles R., Nirmish Shah, Jude Jonassaint, and Laura De Castro. “Usability and Feasibility of an mHealth Intervention for Monitoring and Managing Pain Symptoms in Sickle Cell Disease: The Sickle Cell Disease Mobile Application to Record Symptoms via Technology (SMART).” Hemoglobin 39, no. 3 (2015): 162–68. https://doi.org/10.3109/03630269.2015.1025141.
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  - Shah, Nirmish, Margo Rollins, Daniel Landi, Radhika Shah, Jonathan Bae, and Laura M. De Castro. “Differences in pain management between hematologists and hospitalists caring for patients with sickle cell disease hospitalized for vasoocclusive crisis.” Clin J Pain 30, no. 3 (March 2014): 266–68. https://doi.org/10.1097/AJP.0b013e318295ec04.
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  - Shah, Nirmish, Jude Jonassaint, and Laura De Castro. “Patients welcome the Sickle Cell Disease Mobile Application to Record Symptoms via Technology (SMART).” Hemoglobin 38, no. 2 (2014): 99–103. https://doi.org/10.3109/03630269.2014.880716.
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  - Landi, Daniel, Michele G. Beckman, Nirmish R. Shah, Paula Bockenstedt, Althea M. Grant, John A. Heit, Nigel S. Key, et al. “Characteristics of abdominal vein thrombosis in children and adults.” Thromb Haemost 109, no. 4 (April 2013): 625–32. https://doi.org/10.1160/TH12-08-0568.
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  - Shah, Nirmish, Courtney Thornburg, Marilyn J. Telen, and Thomas L. Ortel. “Characterization of the hypercoagulable state in patients with sickle cell disease.” Thromb Res 130, no. 5 (November 2012): e241–45. https://doi.org/10.1016/j.thromres.2012.08.307.
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  - Verhovsek, Madeleine, Nirmish R. Shah, Ibifiri Wilcox, Sara C. Koenig, Tiago Barros, Courtney D. Thornburg, Martin H. Steinberg, Hong-yuan Luo, and David H. K. Chui. “Severe fetal and neonatal hemolytic anemia due to a 198 kb deletion removing the complete β-globin gene cluster.” Pediatr Blood Cancer 59, no. 5 (November 2012): 941–44. https://doi.org/10.1002/pbc.24094.
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  - Shah, Nirmish R., Thomas Ortel, Elizabeth Thames, and Andra H. James. “Changes in Thrombin Generation During Pregnancy as Measured by Computerized Automated Thrombography (Cat).” American Journal of Hematology 87 (May 1, 2012): S170–S170.
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  - Shah, Nirmish, Daniel Landi, Radhika Shah, Jennifer Rothman, Laura M. De Castro, and Courtney D. Thornburg. “Complications of implantable venous access devices in patients with sickle cell disease.” Am J Hematol 87, no. 2 (February 2012): 224–26. https://doi.org/10.1002/ajh.22230.
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  - Shah, Nirmish R., Daniel B. Landi, Susan G. Kreissman, Evan Kulbachi, and Cassandra Moran. “Presentation and outcomes for children with bone marrow necrosis and acute lymphoblastic leukemia: a literature review.” J Pediatr Hematol Oncol 33, no. 7 (October 2011): e316–19. https://doi.org/10.1097/MPH.0b013e318223fe9b.
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  - Shah, N. R., M. Telen, and T. Ortel. “Evaluation of thrombin generation in sickle cell patients and correlation to clinical disease.” Journal of Thrombosis and Haemostasis 9 (July 1, 2011): 836–836.
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  - Vaughn, Jacqueline, Erika Summers-Goeckerman, Ryan J. Shaw, and Nirmish Shah. “A Protocol to Assess Feasibility, Acceptability, and Usability of Mobile Technology for Symptom Management in Pediatric Transplant Patients.” Nurs Res 68, no. 4 (n.d.): 317–23. https://doi.org/10.1097/NNR.0000000000000343.
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  - Vaughn, Jacqueline, Nirmish Shah, Jude Jonassaint, Nichol Harris, Sharron Docherty, and Ryan Shaw. “User-Centered App Design for Acutely Ill Children and Adolescents.” J Pediatr Oncol Nurs 37, no. 6 (n.d.): 359–67. https://doi.org/10.1177/1043454220938341.
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  - Vaughn, Jacqueline, Siddharth Gollarahalli, Ryan J. Shaw, Sharron Docherty, Qing Yang, Chandni Malhotra, Erika Summers-Goeckerman, and Nirmish Shah. “Mobile Health Technology for Pediatric Symptom Monitoring: A Feasibility Study.” Nurs Res 69, no. 2 (n.d.): 142–48. https://doi.org/10.1097/NNR.0000000000000403.
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- Conference Papers
  - Alambo, A., R. Andrew, S. Gollarahalli, J. Vaughn, T. Banerjee, K. Thirunarayan, D. Abrams, and N. Shah. “Measuring Pain in Sickle Cell Disease using Clinical Text.” In Proceedings of the Annual International Conference of the Ieee Engineering in Medicine and Biology Society, Embs, 2020-July:5838–41, 2020. https://doi.org/10.1109/EMBC44109.2020.9175599.
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  - Yang, Fan, Tanvi Banerjee, Mark J. Panaggio, Daniel M. Abrams, and Nirmish R. Shah. “Continuous Pain Assessment Using Ensemble Feature Selection from Wearable Sensor Data.” In Proceedings (Ieee Int Conf Bioinformatics Biomed), 2019:569–76, 2019. https://doi.org/10.1109/bibm47256.2019.8983282.
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  - Clifton, Sara M., Chaeryon Kang, Jingyi Jessica Li, Qi Long, Nirmish Shah, and Daniel M. Abrams. “Hybrid Statistical and Mechanistic Mathematical Model Guides Mobile Health Intervention for Chronic Pain.” In J Comput Biol, 24:675–88, 2017. https://doi.org/10.1089/cmb.2017.0059.
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Scholarly, Clinical, & Service Activities
Outreach & Engaged Scholarship
- Bass Connections Faculty Team Member . Integrative Global Health Research on Sickle Cell Disease . August 2015 - May 2016 2015 - 2016
- Bass Connections Faculty Team Member. Integrative Global Health Research on Sickle Cell Disease . August 2014 - May 2015 2014 - 2015

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Education, Training, & Certifications

Duke Appointment History

Subject Headings

Global Scholarship

Research

Selected Grants

External Relationships

Selected Publications

Academic Articles

Conference Papers

Outreach & Engaged Scholarship