Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellowship, Neonatal-Perinatal Medicine, Pediatric Neonatology, Duke University School of Medicine 2012 - 2016
  • M.H.S., Duke University School of Medicine 2015
  • Pediatric Residency, Pediatrics, University of Minnesota, Medical School 2008 - 2011
  • M.D., University of Minnesota, Medical School 2008
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Pediatrics, Pediatrics, Neonatology, Pediatrics 2016 - 2020
• Recognition
• 

  In the News

  • FEB 16, 2017

    Duke Health News

    More Extremely Preterm Babies Survive, Live Without Neurological Impairment
• Research
• 

  Selected Grants

  • Bacterial mediators of postnatal growth in preterm infants awarded by National Institutes of Health 2023 - 2024
  • The Microbiome and Metabolism in Postnatal Growth Failure awarded by National Institutes of Health 2019 - 2023
  • Very Low Birthweight (VLBW) Preterm Infant Skin Health with Bundled Care in the NICU: A RCT awarded by Kimberly-Clark Global Sales, LLC 2017 - 2019
  • Growth Failure in Extremely Preterm Infants: Microbiomic and Metabolomic Analysis awarded by Gerber Foundation 2014 - 2018
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Shen, Liangbo L., Shwetha Mangalesh, Suzanne M. Michalak, Brendan McGeehan, Neeru Sarin, Joanne Finkle, Katrina P. Winter, et al. “Associations between systemic health and retinal nerve fibre layer thickness in preterm infants at 36 weeks postmenstrual age.” Br J Ophthalmol 107, no. 2 (February 2023): 242–47. https://doi.org/10.1136/bjophthalmol-2021-319254.
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    • Sayres, Lauren C., Noelle E. Younge, Blaire Rikard, David L. Corcoran, Jennifer L. Modliszewski, and Brenna L. Hughes. “The gestational membrane microbiome in the presence or absence of intraamniotic infection.” Am J Obstet Gynecol Mfm 5, no. 3 (January 7, 2023): 100837. https://doi.org/10.1016/j.ajogmf.2022.100837.
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    • Curtis, Samantha F., C Michael Cotten, Matthew Laughon, Noelle Younge, Jennifer Peterson, Reese H. Clark, and Rachel G. Greenberg. “Indomethacin Prophylaxis in Preterm Infants: Changes over Time.” Am J Perinatol, October 19, 2022. https://doi.org/10.1055/a-1925-5173.
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    • Curtis, Samantha F., C Michael Cotten, Matthew Laughon, Noelle Younge, Jennifer Peterson, Reese H. Clark, and Rachel G. Greenberg. “Indomethacin Prophylaxis in Preterm Infants: Changes over Time.” Am J Perinatol, September 29, 2022. https://doi.org/10.1055/s-0042-1756678.
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    • Chawla, Sanjay, Myra H. Wyckoff, Matthew A. Rysavy, Ravi Mangal Patel, Dhuly Chowdhury, Girija Natarajan, Abbot R. Laptook, et al. “Association of Antenatal Steroid Exposure at 21 to 22 Weeks of Gestation With Neonatal Survival and Survival Without Morbidities.” Jama Netw Open 5, no. 9 (September 1, 2022): e2233331. https://doi.org/10.1001/jamanetworkopen.2022.33331.
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    • Salas, Ariel A., Kent A. Willis, Waldemar A. Carlo, Nengjun Yi, Li Zhang, William J. Van Der Pol, Noelle E. Younge, Elliot J. Lefkowitz, and Charitharth V. Lal. “The gut microbiome of extremely preterm infants randomized to the early progression of enteral feeding.” Pediatric Research 92, no. 3 (September 2022): 799–804. https://doi.org/10.1038/s41390-021-01831-w.
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    • Adams, W Aaron, William Malcolm, Ricki Goldstein, Monica E. Lemmon, Deesha Mago-Shah, Michael Cotten, Jennifer Peterson, Kimberley Fisher, and Noelle Younge. “Longitudinal medical needs for periviable NICU survivors.” Early Hum Dev 169 (June 2022): 105580. https://doi.org/10.1016/j.earlhumdev.2022.105580.
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    • Abdi, Khadar, Ramy Abramsky, Nickie Andescavage, Jephté Bambi, Sudeepta Basu, Cynthia Bearer, Eric J. Benner, et al. “Proceedings of the 13th International Newborn Brain Conference: Fetal and/or neonatal brain development, both normal and abnormal.” J Neonatal Perinatal Med 15, no. 2 (2022): 411–26. https://doi.org/10.3233/NPM-229002.
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    • Brandon, Debra H., Daniel Hatch, Angel Barnes, Ashlee J. Vance, Jane Harney, Barbara Voigtman, and Noelle Younge. “Impact of diaper change frequency on preterm infants' vital sign stability and skin health: A RCT.” Early Hum Dev 164 (January 2022): 105510. https://doi.org/10.1016/j.earlhumdev.2021.105510.
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    • Curtis, Samantha, Noelle Younge, Jennifer Peterson, C Michael Cotten, Samia Aleem, and Rachel G. Greenberg. “Which infants should receive indomethacin prophylaxis: moving closer to individualized medicine in the neonatal intensive care unit.” J Pediatr 237 (October 2021): 318–19. https://doi.org/10.1016/j.jpeds.2021.07.006.
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    • Salas, Ariel A., Waldemar A. Carlo, Barbara T. Do, Edward F. Bell, Abhik Das, Krisa P. Van Meurs, Brenda B. Poindexter, et al. “Growth Rates of Infants Randomized to Continuous Positive Airway Pressure or Intubation After Extremely Preterm Birth.” J Pediatr 237 (October 2021): 148-153.e3. https://doi.org/10.1016/j.jpeds.2021.06.026.
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    • McCann, Jessica R., Nathan A. Bihlmeyer, Kimberly Roche, Cameron Catherine, Jayanth Jawahar, Lydia Coulter Kwee, Noelle E. Younge, et al. “The Pediatric Obesity Microbiome and Metabolism Study (POMMS): Methods, Baseline Data, and Early Insights.” Obesity (Silver Spring) 29, no. 3 (March 2021): 569–78. https://doi.org/10.1002/oby.23081.
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    • Younge, Noelle E. “Probiotics in routine clinical care of moderately preterm infants.” Am J Clin Nutr 112, no. 5 (November 11, 2020): 1153–54. https://doi.org/10.1093/ajcn/nqaa257.
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    • Puia-Dumitrescu, Mihai, Noelle Younge, Daniel K. Benjamin, Katie Lawson, Cordelia Hume, Kennedy Hill, Jonathan Mengistu, et al. “Medications and in-hospital outcomes in infants born at 22-24 weeks of gestation.” J Perinatol 40, no. 5 (May 2020): 781–89. https://doi.org/10.1038/s41372-020-0614-4.
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    • Rysavy, Matthew A., Jeffrey D. Horbar, Edward F. Bell, Lei Li, Lucy T. Greenberg, Jon E. Tyson, Ravi M. Patel, et al. “Assessment of an Updated Neonatal Research Network Extremely Preterm Birth Outcome Model in the Vermont Oxford Network.” Jama Pediatr 174, no. 5 (May 1, 2020): e196294. https://doi.org/10.1001/jamapediatrics.2019.6294.
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    • Puia-Dumitrescu, Mihai, Rachel G. Greenberg, Noelle Younge, Margarita Bidegain, C Michael Cotten, Martin McCaffrey, Amy Murtha, et al. “Disparities in the use of antenatal corticosteroids among women with hypertension in North Carolina.” J Perinatol 40, no. 3 (March 2020): 456–62. https://doi.org/10.1038/s41372-019-0555-y.
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    • Younge, Noelle, Jessica R. McCann, Julie Ballard, Catherine Plunkett, Suhail Akhtar, Félix Araújo-Pérez, Amy Murtha, Debra Brandon, and Patrick C. Seed. “Fetal exposure to the maternal microbiota in humans and mice.” Jci Insight 4, no. 19 (October 3, 2019). https://doi.org/10.1172/jci.insight.127806.
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    • Natarajan, Girija, Seetha Shankaran, Tracy L. Nolen, Amaanti Sridhar, Kathleen A. Kennedy, Susan R. Hintz, Dale L. Phelps, et al. “Neurodevelopmental Outcomes of Preterm Infants With Retinopathy of Prematurity by Treatment.” Pediatrics 144, no. 2 (August 2019). https://doi.org/10.1542/peds.2018-3537.
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    • Younge, Noelle E., Christopher B. Newgard, C Michael Cotten, Ronald N. Goldberg, Michael J. Muehlbauer, James R. Bain, Robert D. Stevens, et al. “Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure.” Sci Rep 9, no. 1 (June 3, 2019): 8167. https://doi.org/10.1038/s41598-019-44547-y.
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    • Younge, Noelle E., Félix Araújo-Pérez, Debra Brandon, and Patrick C. Seed. “Early-life skin microbiota in hospitalized preterm and full-term infants.” Microbiome 6, no. 1 (May 31, 2018): 98. https://doi.org/10.1186/s40168-018-0486-4.
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    • Younge, Noelle, Ricki F. Goldstein, C Michael Cotten, and C Michael Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. “Survival and Neurodevelopment of Periviable Infants.” N Engl J Med 376, no. 19 (May 11, 2017): 1890–91. https://doi.org/10.1056/NEJMc1703379.
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    • Louie, Raymond J., Queenie K-G Tan, Jennifer B. Gilner, R Curtis Rogers, Noelle Younge, Stephanie B. Wechsler, Marie T. McDonald, et al. “Novel pathogenic variants in FOXP3 in fetuses with echogenic bowel and skin desquamation identified by ultrasound.” Am J Med Genet A 173, no. 5 (May 2017): 1219–25. https://doi.org/10.1002/ajmg.a.38144.
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    • Younge, Noelle, Qing Yang, and Patrick C. Seed. “Enteral High Fat-Polyunsaturated Fatty Acid Blend Alters the Pathogen Composition of the Intestinal Microbiome in Premature Infants with an Enterostomy.” J Pediatr 181 (February 2017): 93-101.e6. https://doi.org/10.1016/j.jpeds.2016.10.053.
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    • Younge, Noelle, Ricki F. Goldstein, Carla M. Bann, Susan R. Hintz, Ravi M. Patel, P Brian Smith, Edward F. Bell, et al. “Survival and Neurodevelopmental Outcomes among Periviable Infants.” The New England Journal of Medicine 376, no. 7 (February 2017): 617–28. https://doi.org/10.1056/nejmoa1605566.
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    • Younge, Noelle, P Brian Smith, Kathryn E. Gustafson, William Malcolm, Patricia Ashley, C Michael Cotten, Ronald N. Goldberg, and Ricki F. Goldstein. “Improved survival and neurodevelopmental outcomes among extremely premature infants born near the limit of viability.” Early Hum Dev 95 (April 2016): 5–8. https://doi.org/10.1016/j.earlhumdev.2016.01.015.
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    • Bidegain, M., and N. Younge. “Comfort care vs palliative care: Is there a difference in neonates?” Neoreviews 16, no. 6 (June 1, 2015): e333–39. https://doi.org/10.1542/neo.16-6-e333.
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    • Younge, N., P. B. Smith, R. N. Goldberg, D. H. Brandon, C. Simmons, C. M. Cotten, and M. Bidegain. “Impact of a palliative care program on end-of-life care in a neonatal intensive care unit.” J Perinatol 35, no. 3 (March 2015): 218–22. https://doi.org/10.1038/jp.2014.193.
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    • Ramel, Sara E., Ellen W. Demerath, Heather L. Gray, Noelle Younge, Christopher Boys, and Michael K. Georgieff. “The relationship of poor linear growth velocity with neonatal illness and two-year neurodevelopment in preterm infants.” Neonatology 102, no. 1 (2012): 19–24. https://doi.org/10.1159/000336127.
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    • Ramel, Sara E., Heather L. Gray, Katie L. Ode, Noelle Younge, Michael K. Georgieff, and Ellen W. Demerath. “Body composition changes in preterm infants following hospital discharge: comparison with term infants.” J Pediatr Gastroenterol Nutr 53, no. 3 (September 2011): 333–38. https://doi.org/10.1097/MPG.0b013e3182243aa7.
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  • Conference Papers

    • Mangalesh, Shwetha, Neeru Sarin, Brendan McGeehan, Vincent Tai, Liangbo Shen, Xi Chen, Noelle Younge, et al. “Association between maternal and perinatal systemic factors and macular optical coherence tomography characteristics in preterm infants at 36 weeks postmenstrual age.” In Investigative Ophthalmology & Visual Science, Vol. 62, 2021.
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    • Shen, Liangbo Linus, Shwetha Mangalesh, Suzanne Michalak, Brendan McGeehan, Neeru Sarin, Joanne Finkle, Eric J. Benner, et al. “Sepsis and Necrotizing Enterocolitis are Associated with Thinner Retinal Nerve Fiber Layer in Preterm Infants at 36 Weeks Postmenstrual Age.” In Investigative Ophthalmology & Visual Science, Vol. 62, 2021.
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