Scholars@Duke
David Yanez

David Yanez

Professor of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics

Selected Publications

Design and implementation of community consultation for research conducted under exception from informed consent regulations for the PreVent and the PreVent 2 trials: Changes over time and during the COVID-19 pandemic.

Journal Article Clin Trials · December 2024 INTRODUCTION: Emergency clinical research has played an important role in improving outcomes for acutely ill patients. This is due in part to regulatory measures that allow Exception From Informed Consent (EFIC) trials. The Food and Drug Administration (FD ... Full text Link to item Cite

Relationship of pain relief with catastrophizing following interventional pain procedures for low back pain.

Journal Article Reg Anesth Pain Med · May 13, 2024 INTRODUCTION: Catastrophizing is associated with worse pain outcomes after various procedures suggesting its utility in predicting response. However, the stability of pain catastrophizing as a static predictor has been challenged. We assess, among patients ... Full text Link to item Cite

Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest Trial (GOT ICE): A Randomized Clinical Trial Comparing Outcomes After Aortic Arch Surgery.

Journal Article Circulation · February 27, 2024 BACKGROUND: Deep hypothermia has been the standard for hypothermic circulatory arrest (HCA) during aortic arch surgery. However, centers worldwide have shifted toward lesser hypothermia with antegrade cerebral perfusion. This has been supported by retrospe ... Full text Link to item Cite

Perioperative Complications in Patients with Systemic Sclerosis: A Comparative Cohort Analysis.

Journal Article Med Res Arch · October 2023 BACKGROUND: Systemic sclerosis (SSc) is a rare autoimmune disorder with pathological manifestations affecting multiple organ systems. Few studies have examined perioperative outcomes in patients with this disorder. The primary aim of this retrospective sin ... Full text Open Access Link to item Cite

Comparison of electronic versus phone-based administration of the Quality of Recovery-40 survey after ambulatory surgery.

Journal Article J Clin Anesth · June 2023 STUDY OBJECTIVE: Studies that track patient-centered outcomes are better suited to evaluate the relative benefits and harms of an intervention in ambulatory surgery as severe morbidity and mortality have become increasingly rare. This pilot study aimed to ... Full text Link to item Cite

Comparison between the Rotational Thromboelastometry (ROTEM) Delta device against the Cartridge-based Thromboelastography 6s and Quantra in a healthy third trimester pregnant cohort.

Journal Article J Clin Monit Comput · February 2023 Rotational Thromboelastometry (ROTEM) Delta has been described in several postpartum hemorrhage algorithms, but this device requires pipetting and careful mixing of reagents to initiate the clotting reaction. In contrast, thromboelastography (TEG 6s) and t ... Full text Link to item Cite

Emergency Department Pediatric Readiness and Short-term and Long-term Mortality Among Children Receiving Emergency Care.

Journal Article JAMA Netw Open · January 3, 2023 IMPORTANCE: Emergency departments (EDs) with high pediatric readiness (coordination, personnel, quality improvement, safety, policies, and equipment) are associated with lower mortality among children with critical illness and those admitted to trauma cent ... Full text Link to item Cite

Baseline rotational thromboelastometry (ROTEM) values in a healthy, diverse obstetric population and parameter changes by pregnancy-induced comorbidities.

Journal Article Proc (Bayl Univ Med Cent) · 2023 BACKGROUND: Point-of-care testing provides a representation of the patient's coagulability status during effective postpartum hemorrhage management. Baseline values of rotational thromboelastometry (ROTEM) have not yet been reported in a heterogeneous obst ... Full text Open Access Link to item Cite

Demonstration and Performance Evaluation of Two Novel Algorithms for Removing Artifacts From Automated Intraoperative Temperature Data Sets: Multicenter, Observational, Retrospective Study.

Journal Article JMIR Perioper Med · October 5, 2022 BACKGROUND: The automated acquisition of intraoperative patient temperature data via temperature probes leads to the possibility of producing a number of artifacts related to probe positioning that may impact these probes' utility for observational researc ... Full text Open Access Link to item Cite

Pharmacokinetics and Tolerability of Intraperitoneal Chloroprocaine After Fetal Extraction in Women Undergoing Cesarean Delivery.

Journal Article Anesth Analg · October 1, 2022 BACKGROUND: Intraperitoneal chloroprocaine has been used during cesarean delivery to supplement suboptimal neuraxial anesthesia for decades. The short in vitro half-life of chloroprocaine (11-21 seconds) has been cited to support the safety of this approac ... Full text Link to item Cite

Patterns of Use of Opioid Sparing Adjuncts for Perioperative Pain Management of Patients on Chronic Opioids.

Journal Article Pain Physician · December 2021 BACKGROUND: Perioperative pain management of patients on chronic opioids is challenging. Although experts recommend regional anesthesia and multimodal analgesics for their opioid sparing effects, their use and predictors of use are unknown. OBJECTIVES: To ... Link to item Cite

Variation in propofol induction doses administered to surgical patients over age 65.

Journal Article J Am Geriatr Soc · August 2021 BACKGROUND/OBJECTIVES: Advanced age is associated with increased susceptibility to acute adverse effects of propofol. The present study aimed to describe patterns of propofol dosing for induction of general anesthesia before endotracheal intubation in a na ... Full text Open Access Link to item Cite

Diffuse white matter loss in a transgenic rat model of cerebral amyloid angiopathy.

Journal Article J Cereb Blood Flow Metab · May 2021 Diffuse white matter (WM) disease is highly prevalent in elderly with cerebral small vessel disease (cSVD). In humans, cSVD such as cerebral amyloid angiopathy (CAA) often coexists with Alzheimer's disease imposing a significant impediment for characterizi ... Full text Open Access Link to item Cite

Agreement Between the Mini-Cog in the Preoperative Clinic and on the Day of Surgery and Association With Postanesthesia Care Unit Delirium: A Cohort Study of Cognitive Screening in Older Adults.

Journal Article Anesthesia and analgesia · April 2021 BackgroundCognitive impairment is common in older surgical patients and is associated with postoperative delirium. However, cognitive function is inconsistently assessed preoperatively, leading to missed opportunities to recognize vulnerable patie ... Full text Cite

COVID-19 mortality risk for older men and women.

Journal Article BMC public health · November 2020 BackgroundCase-fatality from COVID-19 has been reported to be relatively high in patients age 65 years or older. We sought to determine the age-specific rates of COVID-19 mortality at the population level.MethodsWe obtained information re ... Full text Open Access Cite

Genetic and pharmacological relationship between P-glycoprotein and increased cardiovascular risk associated with clarithromycin prescription: An epidemiological and genomic population-based cohort study in Scotland, UK.

Journal Article PLoS Med · November 2020 BACKGROUND: There are conflicting reports regarding the association of the macrolide antibiotic clarithromycin with cardiovascular (CV) events. A possible explanation may be that this risk is partly mediated through drug-drug interactions and only evident ... Full text Open Access Link to item Cite

Retrospective chart review and survey to identify adverse safety events in the emergency medical services care of children with out-of-hospital cardiac arrest in the USA: a study protocol.

Journal Article BMJ Open · October 21, 2020 INTRODUCTION: Efforts to improve the quality of emergency medical services (EMS) care for adults with out-of-hospital cardiac arrest (OHCA) have led to improved survival over time. Similar improvements have not been observed for children with OHCA, who may ... Full text Open Access Link to item Cite

Implementation of the TaperGuardâ„¢ endotracheal tube in an unselected surgical population to reduce postoperative pneumonia.

Journal Article BMC Anesthesiol · August 24, 2020 BACKGROUND: Endotracheal tube (ETT) designs to decrease the risk of ventilator associated pneumonia (VAP) include supraglottic suctioning, and/or modifications of the cuff shape. The TaperGuardâ„¢ ETT has a tapered, polyvinylchloride cuff designed to reduce ... Full text Open Access Link to item Cite

Muscular Tissue Oxygen Saturation and Posthysterectomy Nausea and Vomiting: The iMODIPONV Randomized Controlled Trial.

Journal Article Anesthesiology · August 2020 BACKGROUND: Suboptimal tissue perfusion and oxygenation during surgery may be responsible for postoperative nausea and vomiting in some patients. This trial tested the hypothesis that muscular tissue oxygen saturation-guided intraoperative care reduces pos ... Full text Link to item Cite

Randomised controlled trial of sugammadex or neostigmine for reversal of neuromuscular block on the incidence of pulmonary complications in older adults undergoing prolonged surgery.

Journal Article Br J Anaesth · May 2020 BACKGROUND: Residual neuromuscular block has been associated with postoperative pulmonary complications. We hypothesised that sugammadex reduces postoperative pulmonary complications in patients aged ≥70 yr having surgery ≥3 h, compared with neostigmine. M ... Full text Link to item Cite

Randomized controlled trial of acupuncture to prevent emergence delirium in children undergoing myringotomy tube placement.

Journal Article Minerva anestesiologica · February 2020 BackgroundMyringotomy tube placement is a pediatric procedure frequently performed under inhalational anesthesia without intravenous line placement. Emergence delirium is common following sevoflurane anesthesia, and can lead to patient harm and es ... Full text Cite

Oropharyngeal Oxygen Concentration Is Dependent on the Oxygen Mask System and Sampling Location.

Journal Article Respir Care · January 2020 BACKGROUND: Numerous oxygen delivery systems are used to treat hypoxemia. It is unknown if FIO2 at the lips predicts oropharyngeal FIO2 for various oxygen mask systems. We tested whether FIO2 measurements differed between the lips and oropharynx, and wheth ... Full text Link to item Cite

Education Program Regarding Labor Epidurals Increases Utilization by Hispanic Medicaid Beneficiaries: A Randomized Controlled Trial.

Journal Article Anesthesiology · October 2019 BackgroundHispanic women choose epidural labor analgesia less commonly than non-Hispanic women. This may represent a healthcare disparity related to a language barrier and inadequate opportunities for labor analgesia education. It was hypothesized ... Full text Cite

Pericyte constriction underlies capillary derecruitment during hyperemia in the setting of arterial stenosis.

Journal Article Am J Physiol Heart Circ Physiol · August 1, 2019 Capillary derecruitment distal to a coronary stenosis is implicated as the mechanism of reversible perfusion defect and potential myocardial ischemia during coronary hyperemia; however, the underlying mechanisms are not defined. We tested whether pericyte ... Full text Link to item Cite

Inhaled Iloprost Versus Epoprostenol in Heart Transplant Recipients.

Journal Article Respir Care · July 2019 BACKGROUND: Acute right ventricular dysfunction is a challenging problem in the immediate postoperative period following orthotopic heart transplantation. There are no prior reports of the use of inhaled iloprost in the setting of acute right ventricular d ... Full text Link to item Cite

Long-term outcomes among injured older adults transported by emergency medical services.

Journal Article Injury · June 2019 INTRODUCTION/OBJECTIVE: Little is known about the long-term outcomes of injured older adults cared for in trauma systems. We sought to describe mortality and causes of death over time, and the independent association of injury severity, comorbidities, and ... Full text Link to item Cite

Impacts of an opioid overdose prevention intervention delivered subsequent to acute care.

Journal Article Inj Prev · June 2019 BACKGROUND: Opioid overdose is a major and increasing cause of injury and death. There is an urgent need for interventions to reduce overdose events among high-risk persons. METHODS: Adults at elevated risk for opioid overdose involving heroin or pharmaceu ... Full text Open Access Link to item Cite

Inter-rater Reliability of the HEART Score.

Journal Article Acad Emerg Med · May 2019 BACKGROUND: The HEART score is a risk stratification tool for suspected acute coronary syndrome and contains several subjective components. A single previous study found good inter-rater reliability. Our objective was to assess the inter-rater reliability ... Full text Open Access Link to item Cite

Electromagnetic Interference with Protocolized Electrosurgery Dispersive Electrode Positioning in Patients with Implantable Cardioverter Defibrillators.

Journal Article Anesthesiology · April 2019 What we already know about this topicElectromagnetic interference from monopolar electrosurgery may disrupt implantable cardioverter defibrillators.Current management recommendations by the American Society of Anesthesiologists and Heart Rhythm So ... Full text Cite

Cohort Study of Albumin versus Lactated Ringer's for Postoperative Cardiac Surgery Fluid Resuscitation in the Intensive Care Unit.

Journal Article Pharmacotherapy · December 2018 PurposeA new postcardiac surgery fluid resuscitation strategy was implemented in our cardiovascular intensive care unit (CVICU) to implement evidence-based practice. We transitioned from a primarily albumin fluid-based strategy to a lactated Ringe ... Full text Cite

Impact of lung-function measures on cardiovascular disease events in older adults with metabolic syndrome and diabetes.

Journal Article Clin Cardiol · July 2018 BACKGROUND: Individuals with metabolic syndrome (MetS) and diabetes (DM) are more likely to have decreased lung function and are at greater risk of cardiovascular disease (CVD). HYPOTHESIS: Lung-function measures can predict CVD events in older persons wit ... Full text Open Access Link to item Cite

Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration.

Journal Article PLoS One · 2018 AIMS: Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. METHODS AND RESULTS: F ... Full text Open Access Link to item Cite

A comparison of pediatric airway management techniques during out-of-hospital cardiac arrest using the CARES database.

Journal Article Resuscitation · November 2017 OBJECTIVE: To compare odds of survival to hospital discharge among pediatric out-of-hospital cardiac arrest (OHCA) patients receiving either bag-valve-mask ventilation (BVM), supraglottic airway (SGA) or endotracheal intubation (ETI), after adjusting for t ... Full text Link to item Cite

Automatic identification of variables in epidemiological datasets using logic regression.

Journal Article BMC Med Inform Decis Mak · April 13, 2017 BACKGROUND: For an individual participant data (IPD) meta-analysis, multiple datasets must be transformed in a consistent format, e.g. using uniform variable names. When large numbers of datasets have to be processed, this can be a time-consuming and error ... Full text Open Access Link to item Cite

An initiative to optimize waste streams in the operating room: RECycling in the operating room (RECOR) project

Journal Article AANA Journal · April 1, 2017 The goal of this project was to optimally sort waste material in the operating room (OR) environment and divert waste such that streams of low-cost disposal, including recyclable material, could be maximized. Using the Lean Six Sigma method, we followed 5 ... Cite

Assessing the impact of measurement error in modeling change in the absence of auxiliary data

Journal Article Communications in Statistics - Theory and Methods · March 19, 2017 Measurement error is well known to cause bias in estimated regression coefficients and a loss of power for detecting associations. Methods commonly used to correct for bias often require auxiliary data. We develop a solution for investigating associations ... Full text Cite

Effectiveness of a Medical vs Revascularization Intervention for Intermittent Leg Claudication Based on Patient-Reported Outcomes.

Journal Article JAMA Surg · October 19, 2016 IMPORTANCE: Intermittent claudication (IC) is the most common presentation of infrainguinal peripheral artery disease. Both medical and revascularization interventions for IC aim to increase walking comfort and distance, but there is inconclusive evidence ... Full text Link to item Cite

Factors associated with 30-day unplanned pediatric surgical readmission.

Journal Article Am J Surg · September 2016 BACKGROUND: Unplanned readmissions are costly to family satisfaction and negatively associated with quality of care. We hypothesized that patient, operative, and hospital factors would be associated with pediatric readmission. METHODS: All patients with an ... Full text Link to item Cite

Tubular Secretion in CKD.

Journal Article J Am Soc Nephrol · July 2016 Renal function generally is assessed by measurement of GFR and urinary albumin excretion. Other intrinsic kidney functions, such as proximal tubular secretion, typically are not quantified. Tubular secretion of solutes is more efficient than glomerular fil ... Full text Link to item Cite

Randomized Pilot Trial of Two Modified Endotracheal Tubes To Prevent Ventilator-associated Pneumonia.

Journal Article Ann Am Thorac Soc · January 2016 RATIONALE: Ventilator-associated pneumonia (VAP) is a prevalent and costly nosocomial infection related to instrumentation of the airway with an endotracheal tube (ETT), enabling microaspiration of contaminated secretions. Modification of the ETT design to ... Full text Link to item Cite

Impact of an Innovative Classroom-Based Lecture Series on Residents' Evaluations of an Anesthesiology Rotation

Journal Article Anesthesiology Research and Practice · January 1, 2016 Introduction. Millennial resident learners may benefit from innovative instructional methods. The goal of this study is to assess the impact of a new daily, 15 minutes on one anesthesia keyword, lecture series given by faculty member each weekday on reside ... Full text Cite

Inflammatory markers and extent and progression of early atherosclerosis: Meta-analysis of individual-participant-data from 20 prospective studies of the PROG-IMT collaboration.

Journal Article Eur J Prev Cardiol · January 2016 BACKGROUND: Large-scale epidemiological evidence on the role of inflammation in early atherosclerosis, assessed by carotid ultrasound, is lacking. We aimed to quantify cross-sectional and longitudinal associations of inflammatory markers with common-caroti ... Full text Open Access Link to item Cite

Carotid intima-media thickness progression and risk of vascular events in people with diabetes: results from the PROG-IMT collaboration.

Journal Article Diabetes Care · October 2015 OBJECTIVE: Carotid intima-media thickness (CIMT) is a marker of subclinical organ damage and predicts cardiovascular disease (CVD) events in the general population. It has also been associated with vascular risk in people with diabetes. However, the associ ... Full text Open Access Link to item Cite

LV Mass as a Predictor of CVD Events in Older Adults With and Without Metabolic Syndrome and Diabetes.

Journal Article JACC Cardiovasc Imaging · September 2015 OBJECTIVES: The purpose of this study was to examine the prognostic significance of left ventricular (LV) mass for cardiovascular disease (CVD) events in older adults with and without metabolic syndrome (MetS) and diabetes mellitus (DM). BACKGROUND: MetS a ... Full text Open Access Link to item Cite

ACE-inhibition increases podocyte number in experimental glomerular disease independent of proliferation.

Journal Article J Renin Angiotensin Aldosterone Syst · June 2015 OBJECTIVE: The objective of this article is to test the effects of angiotensin-converting enzyme (ACE)-inhibition on glomerular epithelial cell number in an inducible experimental model of focal segmental glomerulosclerosis (FSGS). BACKGROUND: Although ACE ... Full text Open Access Link to item Cite

Randomized pilot trial of intensive management of blood pressure or volume expansion in subarachnoid hemorrhage (IMPROVES).

Journal Article Neurosurgery · February 2015 BACKGROUND: Volume expansion and hypertension are widely used for the hemodynamic management of patients with subarachnoid hemorrhage. OBJECTIVE: To investigate the feasibility, adherence, and retention in a trial of volume expansion and blood pressure man ... Full text Link to item Cite

Variation in tracheal reintubations among patients undergoing cardiac surgery across Washington state hospitals.

Journal Article J Cardiothorac Vasc Anesth · 2015 OBJECTIVES: The objectives of this study were to examine the variation in reintubations across Washington state hospitals that perform cardiac surgery, and explore hospital and patient characteristics associated with variation in reintubation. DESIGN: Retr ... Full text Link to item Cite

Morningness/eveningness chronotype, poor sleep quality, and daytime sleepiness in relation to common mental disorders among Peruvian college students.

Journal Article Psychol Health Med · 2015 The study was designed to investigate the association between sleep disturbances and common mental disorders (CMDs) among Peruvian college students. A total of 2538 undergraduate students completed a self-administered questionnaire to gather information ab ... Full text Link to item Cite

Improved analgesia, sedation, and delirium protocol associated with decreased duration of delirium and mechanical ventilation.

Journal Article Annals of the American Thoracic Society · March 2014 RationaleIntroduction of sedation protocols has been associated with improved patient outcomes. It is not known if an update to an existing high-quality sedation protocol, featuring increased patient assessment and reduced benzodiazepine exposure, ... Full text Cite

Predictors of reintubation in critically ill patients.

Journal Article Respiratory care · February 2014 BackgroundAssessment of a patient's readiness for removal of the endotracheal tube in the ICU is based on respiratory, airway, and neurological measures. However, nearly 20% of patients require reintubation. We created a prediction model for the n ... Full text Cite

Daytime sleepiness, poor sleep quality, eveningness chronotype, and common mental disorders among Chilean college students.

Journal Article J Am Coll Health · 2014 OBJECTIVES: To evaluate whether daytime sleepiness, poor sleep quality, and morningness and eveningness preferences are associated with common mental disorders (CMDs) among college students. METHODS: A total of 963 college students completed self-administe ... Full text Link to item Cite

Washington State's Lystedt law in concussion documentation in Seattle public high schools.

Journal Article J Athl Train · 2014 CONTEXT: The Lystedt law requires high school athletes who have sustained a concussion to be removed from practice and play and not to be allowed to return until cleared by a medical professional. OBJECTIVE: To determine the effect of the Lystedt law on in ... Full text Link to item Cite

Access to multiple sclerosis specialty care.

Journal Article PM R · December 2013 BACKGROUND: Health care providers recommend an annual visit to a multiple sclerosis specialty care provider. OBJECTIVE: To examine potential barriers to the implementation of this recommendation in the Veterans Health Administration. DESIGN: Observational ... Full text Link to item Cite

Impact of inflammatory biomarkers on relation of high density lipoprotein-cholesterol with incident coronary heart disease: cardiovascular Health Study.

Journal Article Atherosclerosis · December 2013 BACKGROUND: Inflammatory factors and low HDL-C relate to CHD risk, but whether inflammation attenuates any protective association of high HDL-C is unknown. OBJECTIVE: Investigate inflammatory markers' individual and collective impact on the association of ... Full text Open Access Link to item Cite

A greater analgesia, sedation, delirium order set quality score is associated with a decreased duration of mechanical ventilation in cardiovascular surgery patients.

Journal Article Crit Care Med · November 2013 OBJECTIVE: Protocols and order sets for the delivery of analgesia, sedation, and delirium care of the critically ill, mechanically ventilated patient have been shown to improve outcomes but are not uniform in hospitals across geographic areas. The extent t ... Full text Link to item Cite

A model for incorporating patient and stakeholder voices in a learning health care network: Washington State's Comparative Effectiveness Research Translation Network.

Journal Article J Clin Epidemiol · August 2013 OBJECTIVE: To describe the inaugural comparative effectiveness research (CER) cohort study of Washington State's Comparative Effectiveness Research Translation Network (CERTAIN), which compares invasive with noninvasive treatments for peripheral artery dis ... Full text Link to item Cite

Etomidate, adrenal function, and mortality in critically ill patients.

Journal Article Respir Care · April 2013 BACKGROUND: In critically ill patients, induction with etomidate is hypothesized to be associated with an increased risk of mortality. Previous randomized studies suggest a modest trend toward an increased risk of death among etomidate recipients; however, ... Full text Link to item Cite

Risk of spontaneous preterm birth in relation to maternal exposure to intimate partner violence during pregnancy in Peru.

Journal Article Matern Child Health J · April 2013 Intimate partner violence (IPV) is increasingly recognized as an important cause of maternal and perinatal morbidity. We assessed the relation between IPV and risk of spontaneous preterm birth (PTB) among Peruvian women. The study was conducted among 479 p ... Full text Link to item Cite

Weight loss after diagnosis with gestational diabetes and birth weight among overweight and obese women.

Journal Article Matern Child Health J · February 2013 To determine if, among overweight or obese women with gestational diabetes (GDM), weight loss after GDM diagnosis is associated with lower infant birth weight within levels of overweight or obesity class. Overweight and obese women with singleton pregnanci ... Full text Link to item Cite

Risk of spontaneous preterm birth in relation to maternal depressive, anxiety, and stress symptoms.

Journal Article J Reprod Med · 2013 OBJECTIVE: To examine the risk of preterm birth (PTB) in relation to maternal psychiatric symptoms during pregnancy in Peruvian women. STUDY DESIGN: This case-control study included 479 PTB cases and 480 term controls. In-person interviews were conducted t ... Open Access Link to item Cite

Importance of perioperative glycemic control in general surgery: a report from the Surgical Care and Outcomes Assessment Program.

Journal Article Ann Surg · January 2013 OBJECTIVE: To determine the relationship of perioperative hyperglycemia and insulin administration on outcomes in elective colon/rectal and bariatric operations. BACKGROUND: There is limited evidence to characterize the impact of perioperative hyperglycemi ... Full text Link to item Cite

Mortality and long-term functional outcome associated with intracranial pressure after traumatic brain injury.

Journal Article Intensive care medicine · November 2012 PurposeElevated intracranial pressure (ICP) has been associated with increased mortality in patients with severe traumatic brain injury (TBI). We have examined whether raised ICP is independently associated with mortality, functional status and ne ... Full text Cite

The association between fluid balance and outcomes after subarachnoid hemorrhage.

Journal Article Neurocritical care · October 2012 BackgroundWe sought to determine the association between early fluid balance and neurological/vital outcome of patients with subarachnoid hemorrhage.MethodsHospital admission, imaging, ICU and outcome data were retrospectively collected f ... Full text Cite

Occurrence and complications of tracheal reintubation in critically ill adults.

Journal Article Respiratory care · October 2012 BackgroundTiming and preparation for tracheal extubation are as critical as the initial intubation. There are limited data on specific strategies for a planned extubation. The extent to which the difficult airway at reintubation contributes to pat ... Full text Cite

Racial and ethnic differences in adjuvant hormonal therapy use.

Journal Article J Womens Health (Larchmt) · September 2012 BACKGROUND: In the United States, 5-year breast cancer survival is highest among Asian American women, followed by non-Hispanic white, Hispanic, and African American women. Breast cancer treatment disparities may play a role. We examined racial/ethnic diff ... Full text Link to item Cite

Association between hospital volume and network membership and an analgesia, sedation and delirium order set quality score: a cohort study.

Journal Article Crit Care · June 18, 2012 INTRODUCTION: Protocols for the delivery of analgesia, sedation and delirium care of the critically ill, mechanically ventilated patient have been shown to improve outcomes but are not uniformly used. The extent to which elements of analgesia, sedation and ... Full text Open Access Link to item Cite

Antenatal haemoglobin A1c and risk of large-for-gestational-age infants in a multi-ethnic cohort of women with gestational diabetes.

Journal Article Paediatr Perinat Epidemiol · May 2012 Gestational diabetes mellitus (GDM) is a risk factor for delivering a large-for-gestational-age (LGA) infant. Haemoglobin A1c (A1C) is an indicator of glycaemic control. The objective of this study was to test whether higher A1C quartile at the time of dia ... Full text Open Access Link to item Cite

Hemoglobin A1c and postpartum abnormal glucose tolerance among women with gestational diabetes mellitus.

Journal Article Obstet Gynecol · March 2012 OBJECTIVE: To analyze the association of hemoglobin A1c (HbA1c) at gestational diabetes mellitus (GDM) diagnosis with postpartum abnormal glucose in a cohort of women with GDM. METHODS: Women with singleton pregnancies treated for GDM at a large diabetes a ... Full text Link to item Cite

Waist circumference, body mass index, and other measures of adiposity in predicting cardiovascular disease risk factors among peruvian adults

Journal Article International Journal of Hypertension · December 1, 2011 Objectives. To examine the extent to which measures of adiposity can be used to predict selected components of metabolic syndrome (MetS) and elevated C-reactive protein (CRP). Methods. A total of 1,518 Peruvian adults were included in this study. Waist cir ... Full text Cite

Associations of cardiovascular risk factors, carotid intima-media thickness and left ventricular mass with inter-adventitial diameters of the common carotid artery: the Multi-Ethnic Study of Atherosclerosis (MESA).

Journal Article Atherosclerosis · October 2011 BACKGROUND: Common carotid artery inter-adventitial diameter (IAD) and intima-media thickness (IMT) are measurable by ultrasound. IAD may be associated with left ventricular mass (LV mass) while IMT is a marker of subclinical atherosclerosis. It is not cle ... Full text Link to item Cite

Cardioplegia and ventricular late potentials in cardiac surgical patients.

Journal Article J Clin Monit Comput · August 2011 BACKGROUND AND OBJECTIVE: Ventricular late potentials (LP) recording with signal-averaged electrocar- diogram allow identifying patients at risk of sudden death and ventricular tachycardia. Cardiac surgery with cardiopulmonary bypass (CPB) could predispose ... Full text Link to item Cite

Open-label randomized trial of the safety and efficacy of a single dose conivaptan to raise serum sodium in patients with traumatic brain injury.

Journal Article Neurocrit Care · June 2011 BACKGROUND: Conivaptan is an arginine-vasopressin-receptor antagonist approved for the treatment of hyponatremia. We hypothesized that administration of conivaptan to normonatremic patients with traumatic brain injury (TBI) is safe and could reduce intracr ... Full text Link to item Cite

Current practices of triple-H prophylaxis and therapy in patients with subarachnoid hemorrhage.

Journal Article Neurocrit Care · February 2011 BACKGROUND: Medical management of cerebral vasospasm following aneurysmal subarachnoid hemorrhage (SAH) includes hypertensive, hypervolemic, and hemodilution ("triple-H") therapy. However, there is little information regarding the indications and guidance ... Full text Link to item Cite

Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project.

Journal Article Am Heart J · May 2010 Carotid intima media thickness (IMT) progression is increasingly used as a surrogate for vascular risk. This use is supported by data from a few clinical trials investigating statins, but established criteria of surrogacy are only partially fulfilled. To p ... Full text Link to item Cite

Atrial and brain natriuretic peptide concentrations and the response to inhaled nitric oxide in patients with acute respiratory distress syndrome.

Journal Article J Crit Care · March 2010 PURPOSE: The response to inhaled nitric oxide (iNO) is inconsistent in patients with acute respiratory distress syndrome (ARDS). We sought to determine whether the response to iNO, defined as 20% Pao(2)/Fio(2) increase from baseline, depends on the level o ... Full text Link to item Cite

Combined association of lipids and blood pressure in relation to incident cardiovascular disease in the elderly: the cardiovascular health study.

Journal Article Am J Hypertens · February 2010 BACKGROUND: Hypertension and dyslipidemia are highly prevalent in the elderly. We studied the combined impact of both conditions on cardiovascular disease (CVD) events. METHODS: We studied 4,311 participants aged 65-98 (61.2% female) from the Cardiovascula ... Full text Link to item Cite

Sibling history of myocardial infarction or stroke and risk of cardiovascular disease in the elderly: the Cardiovascular Health Study.

Journal Article Ann Epidemiol · December 2009 PURPOSE: To assess the relationship between sibling history of myocardial infarction (MI) or stroke with cardiovascular disease (CVD) and risk factors in older adults. METHODS: Prospective cohort study of 5,888 older adults participating in the Cardiovascu ... Full text Link to item Cite

The relationship of bottle feeding and other sucking behaviors with speech disorder in Patagonian preschoolers.

Journal Article BMC Pediatr · October 21, 2009 BACKGROUND: Previous studies have shown that children's nonnutritive sucking habits may lead to delayed development of their oral anatomy and functioning. However, these findings were inconsistent. We investigated associations between use of bottles, pacif ... Full text Link to item Cite

Management guided by brain tissue oxygen monitoring and outcome following severe traumatic brain injury.

Journal Article Journal of neurosurgery · October 2009 ObjectThe authors sought to describe changes in clinical management associated with brain tissue oxygen (PbO(2)) monitoring and how these changes affected outcomes and resource utilization.MethodsThe cohort study comprised 629 patients ad ... Full text Cite

Randomized trial of light versus deep sedation on mental health after critical illness.

Journal Article Critical care medicine · September 2009 Objectives: To investigate if light sedation favorably affects subsequent patient mental health compared with deep sedation. Symptoms of posttraumatic stress disorder are common in patients after they have undergone prolonged mechanical ventilatio ... Full text Cite

Accuracy of transcranial Doppler ultrasonography and single-photon emission computed tomography in the diagnosis of angiographically demonstrated cerebral vasospasm.

Journal Article J Neurosurg · January 2009 OBJECT: The goal of this study was to assess the accuracy of the routine clinical use of transcranial Doppler (TCD) ultrasonography and SPECT in predicting angiographically demonstrated vasospasm. METHODS: Following receipt of institutional review board ap ... Full text Link to item Cite

Racial disparities among patients with lung cancer who were recommended operative therapy.

Journal Article Arch Surg · January 2009 HYPOTHESIS: Health care system and provider biases and differences in patient characteristics are thought to be prevailing factors underlying racial disparities. The influence of these factors on the receipt of care would likely be mitigated among patients ... Full text Link to item Cite

Temporal trends in the management of potentially resectable lung cancer.

Journal Article Ann Thorac Surg · June 2008 BACKGROUND: Standardized, evidence-based guidelines recommend lung resection for patients with stage I or II nonsmall-cell lung cancer (NSCLC), and select patients with stage IIIA disease. We hypothesized that the proportion of patients operated on would i ... Full text Link to item Cite

Age-specific prevalence and years of healthy life in a system with three health states.

Journal Article Stat Med · April 30, 2008 Consider a 3-state system with one absorbing state, such as Healthy, Sick, and Dead. Over time, the prevalence of the Healthy state will approach an 'equilibrium' value that is independent of the initial conditions. We derived this equilibrium prevalence ( ... Full text Link to item Cite

Intensive insulin therapy and mortality in critically ill patients.

Journal Article Crit Care · 2008 INTRODUCTION: Intensive insulin therapy (IIT) with tight glycemic control may reduce mortality and morbidity in critically ill patients and has been widely adopted in practice throughout the world. However, there is only one randomized controlled trial sho ... Full text Link to item Cite

Effect of intensive care unit organizational model and structure on outcomes in patients with acute lung injury.

Journal Article American journal of respiratory and critical care medicine · October 2007 RationalePrior studies supported an association between intensive care unit (ICU) organizational model or staffing patterns and outcome in critically ill patients.ObjectivesTo examine the association of closed versus open models with pati ... Full text Cite

Inflammation biomarkers and near-term death in older men.

Journal Article Am J Epidemiol · March 15, 2007 Associations of C-reactive protein (CRP) and fibrinogen with death may weaken over time. Combining both markers may improve prediction of death in older adults. In 5,828 Cardiovascular Health Study participants (United States, 1989-2000), 383 deaths (183 c ... Full text Link to item Cite

Role of intracranial pressure values and patterns in predicting outcome in traumatic brain injury: a systematic review.

Journal Article Neurocritical care · January 2007 IntroductionRaised intracranial pressure (ICP) has been consistently associated with poor neurological outcome. Our purpose was to systematically review the literature to estimate the association between ICP values and patterns and short- and long ... Full text Cite

The association between time since last meal and blood pressure in older adults: the cardiovascular health study.

Journal Article J Am Geriatr Soc · June 2003 OBJECTIVES: To demonstrate a postprandial hypotensive (PPH) phenomenon in older adults. DESIGN: Observational, prospective cohort study composed of baseline and nine follow-up visits. SETTING: Cardiovascular Health Study, an epidemiological study of risk f ... Full text Link to item Cite

Serum homocysteine, thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), and venous thromboembolism: Longitudinal Investigation of Thromboembolism Etiology (LITE).

Journal Article Am J Hematol · March 2003 We sought to examine prospectively the association of serum homocysteine and the methylene tetrahydrofolate reductase (MTHFR) C677T gene polymorphism with risk of venous thromboembolism (VTE). We studied these relationships in a nested case-control study o ... Full text Link to item Cite

Heart rate variability is confounded by the presence of erratic sinus rhythm

Conference Computers in Cardiology · December 1, 2002 Decreased heart rate variability (HRV) predicts adverse outcomes. HRV can be elevated by episodes of significant non-respiratory sinus arrhythmia (i.e., a highly erratic sinus rhythm with normal p-waves, ESR). This elevated HRV could confound risk stratifi ... Cite

Analysing change in clinical trials using quasi-likelihoods

Journal Article Journal of Applied Statistics · November 1, 2002 In clinical trials, investigations focus upon whether a treatment affects a measured outcome. Data often collected include pre- and post-treatment measurements on each patient and an analysis of the change in the outcome is typically performed to determine ... Full text Cite

A prospective study of venous thromboembolism in relation to factor V Leiden and related factors.

Journal Article Blood · April 15, 2002 The aim of this study was to examine the occurrence of venous thromboembolism (VTE) in relation to factor V-related risk factors. Using a nested case-control design combining 2 population-based prospective studies, we measured factor V Leiden, HR2 haplotyp ... Full text Link to item Cite

A regression model for longitudinal change in the presence of measurement error.

Journal Article Ann Epidemiol · January 2002 PURPOSE: The analysis of change in measured variables has become quite popular in studies where data are collected repeatedly over time. The authors describe some of the potential pitfalls in the analysis of change when the variable for change is measured ... Full text Link to item Cite

Correlates of peak expiratory flow lability in elderly persons.

Journal Article Chest · December 2001 OBJECTIVE: To determine the correlates of the lability of peak expiratory flow (PEF) in the elderly. METHODS: A community sample of 4,581 persons > or = 65 years old from the Cardiovascular Health Study completed an asthma questionnaire and underwent spiro ... Full text Link to item Cite

Weight change in old age and its association with mortality.

Journal Article J Am Geriatr Soc · October 2001 OBJECTIVES: Previous studies of weight change and mortality in older adults have relied on self-reported weight loss, have not evaluated weight gain, or have had limited information on health status. Our objective was to determine whether 5% weight gain or ... Full text Link to item Cite

A univariate measurement error model for longitudinal change

Journal Article Communications in Statistics - Theory and Methods · January 1, 2001 Analyses of variables measured with error are often flawed when measurement error is ignored. An extensive literature on linear measurement error models is available by (1), and more recently, for non-linear measurement error models by (2) and (3). We inve ... Full text Cite

Orthostatic hypotension in the elderly: Contributions of impaired LV filling and altered sympathovagal balance

Journal Article American Journal of Geriatric Cardiology · January 1, 2000 Orthostatic hypotension, which occurs in 5%-18% of the elderly, may contribute to age-related disability. While autonomic dysfunction and alterations of cardiac structure and function likely to impair postural maintenance of blood pressure are common in th ... Full text Cite

Prevalence, predisposing factors, and prognosis of clinically unrecognized myocardial infarction in the elderly.

Journal Article J Am Coll Cardiol · January 2000 OBJECTIVES: This study was designed to determine the prevalence of unrecognized myocardial infarction (UMI), as well as risk factors, and to compare prognosis after detection of previously UMI to that after recognized myocardial infarction (RMI). BACKGROUN ... Full text Link to item Cite

Methods for analyzing health care utilization and costs.

Book · 1999 Important questions about health care are often addressed by studying health care utilization. Utilization data have several characteristics that make them a challenge to analyze. In this paper we discuss sources of information, the statistical properties ... Full text Link to item Cite

The effects of measurement error in response variables and tests of association of explanatory variables in change models.

Journal Article Stat Med · November 30, 1998 Biomedical studies often measure variables with error. Examples in the literature include investigation of the association between the change in some outcome variable (blood pressure, cholesterol level etc.) and a set of explanatory variables (age, smoking ... Full text Link to item Cite

Factors associated with hospital utilization in the elderly: From the cardiovascular health study

Journal Article American Journal of Geriatric Cardiology · May 1, 1998 Objective: Analyze clinical accepted biochemical physiologic, and socioeconomic risk factors and correlate them with hospital utilization in an elderly population. Design: Prospective, observational study in a defined, randomly recruited population. Partic ... Cite

Association of fibrinogen and coagulation factors VII and VIII with cardiovascular risk factors in the elderly: the Cardiovascular Health Study. Cardiovascular Health Study Investigators.

Journal Article Am J Epidemiol · April 1, 1996 The cross-sectional correlates of three hemostatic factors--fibrinogen, factor VII, and factor VIII--were examined in the Cardiovascular Health Study, a population-based cohort study of 5,201 subjects over age 65 years. Subjects were recruited in 1989-1990 ... Full text Link to item Cite

Fibrinogen and factor VIII, but not factor VII, are associated with measures of subclinical cardiovascular disease in the elderly. Results from The Cardiovascular Health Study.

Journal Article Arterioscler Thromb Vasc Biol · September 1995 No studies have examined the associations of coagulation factor levels with measures of subclinical cardiovascular disease (CVD) in the elderly. The Cardiovascular Health Study (CHS) is a prospective, population-based cohort study of CVD in persons older t ... Full text Link to item Cite

Temporal patterns of antihypertensive medication use among older adults, 1989 through 1992. An effect of the major clinical trials on clinical practice?

Journal Article JAMA · May 10, 1995 OBJECTIVE: To describe the changing patterns of antihypertensive medication use in the years immediately before and after the publication of the results of three major clinical trials of the treatment of hypertension in older adults. DESIGN: In this cohort ... Link to item Cite