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Nuo Li

Associate Professor of Neurobiology
Neurobiology

Overview


We study how the brain generates volitional movement. We develop tools to map, manipulate, and analyze multi-regional circuits in the intact brain during behavior in the mouse. Our goal is to produce a holistic and circuit-based understanding of volitional movement that will provide a roadmap for treating movement disorders. More broadly, we use volitional movement as a model to understand how multi-regional circuits perform fundamental computations that support cognition.

Current Appointments & Affiliations


Associate Professor of Neurobiology · 2024 - Present Neurobiology, Basic Science Departments

Recent Publications


A brainstem map of orofacial rhythms.

Journal Article bioRxiv · January 27, 2025 Rhythmic orofacial movements, such as eating, drinking, or vocalization, are controlled by distinct premotor oscillator networks in the brainstem. Orofacial movements must be coordinated with rhythmic breathing to avoid aspiration and because they share mu ... Full text Link to item Cite

A combinatorial neural code for long-term motor memory.

Journal Article Nature · January 2025 Motor skill repertoire can be stably retained over long periods, but the neural mechanism that underlies stable memory storage remains poorly understood1-8. Moreover, it is unknown how existing motor memories are maintained as new motor skills are continuo ... Full text Link to item Cite
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Recent Grants


Neural control of rhythmic orofacial movements

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2029

Opponent control of action selection in the cortico-basal-ganglia-colliculus loop

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2028

Neural computations and circuit mechanisms of changes of mind in the mouse and monkey

ResearchPrincipal Investigator · Awarded by New York University · 2024 - 2025

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Education, Training & Certifications


Massachusetts Institute of Technology · 2011 Ph.D.