Overview
Functional genomics
Non-coding regulatory variants in the human genome
Genetics of complex neurological diseases
Non-coding regulatory variants in the human genome
Genetics of complex neurological diseases
Current Appointments & Affiliations
Professor in Neurology
·
2025 - Present
Neurology, Translational Brain Sciences,
Neurology
Division Chief, Translational Brain Sciences in the Department of Neurology
·
2019 - Present
Neurology,
Clinical Science Departments
Professor in Pathology
·
2020 - Present
Pathology,
Clinical Science Departments
Associate of the Duke Initiative for Science & Society
·
2018 - Present
Duke Science & Society,
University Initiatives & Academic Support Units
Recent Publications
APOE-Targeted Therapeutics for Alzheimer's Disease.
Journal Article J Neurosci · November 12, 2025 Apolipoprotein E (APOE) is the major lipid transport protein in the brain. Produced primarily by astrocytes and microglia, it delivers cholesterol and other lipids for membrane repair, synaptic maintenance, and immune regulation. Through interactions with ... Full text Link to item CiteMicroglial States Are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's Disease.
Journal Article Aging Cell · October 2025 Cellular senescence is a major contributor to aging-related degenerative diseases, including Alzheimer's disease (AD), but much less is known about the key cell types and pathways driving senescence mechanisms in the brain. We hypothesized that dysregulate ... Full text Link to item CiteTrends and challenges of AAV-delivered gene editing therapeutics for CNS disorders: Implications for neurodegenerative disease.
Journal Article Mol Ther Nucleic Acids · September 9, 2025 Recent advances in gene-editing technologies offer new opportunities for drug development to treat unmet medical needs in central nervous system (CNS) disorders including neurogenerative diseases of the aging brain. The adeno-associated virus (AAV) is a pr ... Full text Link to item CiteRecent Grants
Duke Creating ADRD Researchers for the Next Generation - Stimulating Access to Research in Residency Program (CARiNG-StARR)"
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2020 - 2026Untangling the diversity in the genetic architecture of late-onset Alzheimer's disease using single cell multi-omics
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2026Sex-dependent genetic landscape of late-onset Alzheimer's disease
ResearchPrincipal Investigator · Awarded by Alzheimer's Association · 2022 - 2026View All Grants
Education, Training & Certifications
Hebrew University (Israel) ·
1999
Ph.D.