Overview
Functional genomics
Non-coding regulatory variants in the human genome
Genetics of complex neurological diseases
Non-coding regulatory variants in the human genome
Genetics of complex neurological diseases
Current Appointments & Affiliations
Professor in Neurology
·
2025 - Present
Neurology, Translational Brain Sciences,
Neurology
Division Chief, Translational Brain Sciences in the Department of Neurology
·
2019 - Present
Neurology,
Clinical Science Departments
Professor in Pathology
·
2020 - Present
Pathology,
Clinical Science Departments
Associate of the Duke Initiative for Science & Society
·
2018 - Present
Duke Science & Society,
University Initiatives & Academic Support Units
Recent Publications
Basic Science and Pathogenesis.
Journal Article Alzheimers Dement · December 2025 BACKGROUND: The multifactorial and heterogenous nature of Late Onset Alzheimer's disease (LOAD) presents a challenge, particularly in capturing genetic complexity across diverse populations. Recent single-nucleus (sn)multi-omics analyses have advanced the ... Full text Link to item CiteBasic Science and Pathogenesis.
Journal Article Alzheimers Dement · December 2025 BACKGROUND: Late-onset Alzheimer's disease (LOAD) patients often have comorbid neuropsychiatric symptoms (NPS) with depression and anxiety being most prevalent. Neuropsychiatric disorders including major depressive disorder (MDD) confer risk for LOAD later ... Full text Link to item CiteAPOE-Targeted Therapeutics for Alzheimer's Disease.
Journal Article J Neurosci · November 12, 2025 Apolipoprotein E (APOE) is the major lipid transport protein in the brain. Produced primarily by astrocytes and microglia, it delivers cholesterol and other lipids for membrane repair, synaptic maintenance, and immune regulation. Through interactions with ... Full text Link to item CiteRecent Grants
Duke Creating ADRD Researchers for the Next Generation - Stimulating Access to Research in Residency Program (CARiNG-StARR)"
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2020 - 2026Untangling the diversity in the genetic architecture of late-onset Alzheimer's disease using single cell multi-omics
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2026Sex-dependent genetic landscape of late-onset Alzheimer's disease
ResearchPrincipal Investigator · Awarded by Alzheimer's Association · 2022 - 2026View All Grants
Education, Training & Certifications
Hebrew University (Israel) ·
1999
Ph.D.