Christopher Michael O'Connor

Christopher Michael O'Connor
Richard Sean Stack, M.D. / Guidant Foundation Distinguished Professor of Cardiology

Dr. O’Connor’s research interests include: acute heart failure; co-morbidities in heart failure; clinical trials; biomarkers; and novel pharmacological and non-pharmacological approaches for the treatment of heart failure.

Current Appointments & Affiliations

Richard Sean Stack, M.D. / Guidant Foundation Distinguished Professor of Cardiology, Medicine, Clinical Pharmacology, Medicine 2014
Adjunct Professor in the Department of Medicine, Medicine, Clinical Pharmacology, Medicine 2016

Contact Information

7401 Hosp North, Durham, NC 27710
Duke Box 3356, Durham, NC 27710
oconn002@mc.duke.edu (919) 681-6195

Background
Education, Training, & Certifications
- Fellow in Cardiology, Medicine, Duke University 1988 - 1989
- Chief Medical Resident - VAMC, Medicine, Duke University 1987 - 1988
- Cardiology Fellow, Medicine, Duke University 1986 - 1987
- Medical Resident, Medicine, Duke University 1983 - 1986
- M.D., University of Maryland, College Park 1983
Duke Appointment History
- Member in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 1985 - 2016
- Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2001 - 2016
- Director, of the Heart Center/Cardiovascular CSU, Medicine, Clinical Science Departments 2007 - 2016
- Adjunct Professor in the Department of Medicine, Medicine, Cardiology, Medicine 2015 - 2016
- Professor of Medicine, Medicine, Cardiology, Medicine 2003 - 2015
- Chief, Division of Clinical Pharmacology in the Department of Medicine, Medicine, Clinical Pharmacology, Medicine 2001 - 2015
- Chief, Division of Cardiology, Medicine, Cardiology, Medicine 2012 - 2015
- Acting Chief of the Division of Cardiology, Medicine, Cardiology, Medicine 2010 - 2012
- Associate Professor of Medicine, Medicine, Cardiology, Medicine 1999 - 2003
- Associate Professor of Medicine, Medicine, Cardiology, Medicine 1996 - 1999
- Assistant Professor of Medicine, Medicine, Cardiology, Medicine 1990 - 1996
- Associate in the Department of Medicine, Medicine, Clinical Science Departments 1989 - 1990
Recognition
In the News
- NOV 19, 2019
  
  Global List of Highly Cited Puts Duke in Top Ten
- NOV 27, 2018
  
  Duke Faculty Plentiful On ‘Highly Cited’ List
Expertise
Subject Headings
Research
Selected Grants
- Duke-UNC Clinical Hematology and Transfusion Research Career Development Program awarded by National Institutes of Health 2006 - 2019
- STICHES awarded by National Institutes of Health 2011 - 2019
- GUIDing Evidence Based Therapy Using Biomarker Intensified Treatment (CCC) awarded by National Institutes of Health 2012 - 2017
- Palliative Care in Heart Failure (PAL-HF) awarded by National Institutes of Health 2011 - 2016
- UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program awarded by University of North Carolina - Chapel Hill 2011 - 2016
- Coping Skills Training in Heart Failure: Outcomes and Mechanisms awarded by National Institutes of Health 2009 - 2015
- Responses of Myocardial Ischemia to Sertraline Treatment awarded by National Institutes of Health 2006 - 2013
- Heart Failure Clinical Research Network awarded by National Institutes of Health 2006 - 2011
- STICH Trial - Coordinating Center awarded by National Institutes of Health 2002 - 2011
- Pharmacometabolomics Research Network awarded by National Institutes of Health 2010 - 2011
- Safety and Efficacy of Sertraline for Depression CHF awarded by National Institutes of Health 2003 - 2011
- A CHF Trial Investigating Outcomes of Exercise Training awarded by National Institutes of Health 2002 - 2010
- HF Action Supplement awarded by National Institutes of Health 2002 - 2010
- Inflammation & Prognosis in Decompensated Heart Failure awarded by National Institutes of Health 2004 - 2010
- ESCAPE - Evaluation Study of Congestive Heart Failure and Pulmonary Artery.. awarded by National Institutes of Health 1999 - 2008
- ESCAPE Mechanistic Substudy Grant Application awarded by National Institutes of Health 2001 - 2006
- Enhancing Recovery In Coronary Heart Disease Patients awarded by National Institutes of Health 1995 - 2005
- Stress & Congestive Heart Failure:Prognosis & Mechanisms awarded by National Institutes of Health 1999 - 2005
- Warfarin and antiplatelet therapy study in chronic heart failure (CSP#442) 1999 - 2004
- Inflammatory Biomarkers in Depressed CHF Patients awarded by National Institutes of Health 2003 - 2004
- Depression In Elderly Cardiac Patients awarded by National Institutes of Health 1994 - 2003
- Beta-Blocker Evaluation Of Survival Trial (Best) 1995 - 2001
- Heart Failure Specialized Center Of Research awarded by National Institutes of Health 1995 - 1999
External Relationships
- Arca Biopharma, Inc.
- Bayer
- Bristol Myers Squibb Foundation
- Dey, L.P. (Merck)
Publications & Artistic Works
Selected Publications
- Academic Articles
  - O’Connor, Christopher M. “The Heart Failure High Five: Medical Therapy and Policy: 2019.” Jacc Heart Fail 8, no. 1 (January 2020): 81–82. https://doi.org/10.1016/j.jchf.2019.11.008.
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  - Psotka, Mitchell A., Gregg C. Fonarow, Larry A. Allen, Karen E. Joynt Maddox, Mona Fiuzat, Paul Heidenreich, Adrian F. Hernandez, Marvin A. Konstam, Clyde W. Yancy, and Christopher M. O’Connor. “The Hospital Readmissions Reduction Program: Nationwide Perspectives and Recommendations: A JACC: Heart Failure Position Paper.” Jacc Heart Fail 8, no. 1 (January 2020): 1–11. https://doi.org/10.1016/j.jchf.2019.07.012.
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  - Yang, Siyun, Monique Anderson Starks, Adrian F. Hernandez, Elizabeth L. Turner, Robert M. Califf, Christopher M. O’Connor, Robert J. Mentz, and Kingshuk Roy Choudhury. “Impact of baseline covariate imbalance on bias in treatment effect estimation in cluster randomized trials: Race as an example.” Contemp Clin Trials 88 (January 2020): 105775. https://doi.org/10.1016/j.cct.2019.04.016.
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  - Butler, Javed, Milton Packer, Stephen J. Greene, Mona Fiuzat, Stefan D. Anker, Kevin J. Anstrom, Peter E. Carson, et al. “Heart Failure End Points in Cardiovascular Outcome Trials of Sodium Glucose Cotransporter 2 Inhibitors in Patients With Type 2 Diabetes Mellitus: A Critical Evaluation of Clinical and Regulatory Issues.” Circulation 140, no. 25 (December 17, 2019): 2108–18. https://doi.org/10.1161/CIRCULATIONAHA.119.042155.
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  - Caraballo, César, Nihar R. Desai, Hillary Mulder, Brooke Alhanti, F Perry Wilson, Mona Fiuzat, G Michael Felker, et al. “Clinical Implications of the New York Heart Association Classification.” J Am Heart Assoc 8, no. 23 (December 3, 2019): e014240. https://doi.org/10.1161/JAHA.119.014240.
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  - Pandhi, Paloma, Jozine M. Ter Maaten, Johanna E. Emmens, Joachim Struck, Andreas Bergmann, John G. Cleland, Michael M. Givertz, et al. “Clinical value of pre-discharge bio-adrenomedullin as a marker of residual congestion and high risk of heart failure hospital readmission.” Eur J Heart Fail, December 3, 2019. https://doi.org/10.1002/ejhf.1693.
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  - O’Connor, Christopher M. “N-1 and Sequencing Clinical Heart Failure Trials: Charting the Path for Future Clinical Care.” Jacc Heart Fail 7, no. 12 (December 2019): 1089–90. https://doi.org/10.1016/j.jchf.2019.10.006.
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  - Pieske, Burkert, Mahesh J. Patel, Cynthia M. Westerhout, Kevin J. Anstrom, Javed Butler, Justin Ezekowitz, Adrian F. Hernandez, et al. “Baseline features of the VICTORIA (Vericiguat Global Study in Subjects with Heart Failure with Reduced Ejection Fraction) trial.” Eur J Heart Fail 21, no. 12 (December 2019): 1596–1604. https://doi.org/10.1002/ejhf.1664.
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  - Regan, Jessica A., Dalane W. Kitzman, Eric S. Leifer, William E. Kraus, Jerome L. Fleg, Daniel E. Forman, David J. Whellan, et al. “Impact of Age on Comorbidities and Outcomes in Heart Failure With Reduced Ejection Fraction.” Jacc Heart Fail 7, no. 12 (December 2019): 1056–65. https://doi.org/10.1016/j.jchf.2019.09.004.
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  - Beldhuis, Iris E., Koen W. Streng, Peter van der Meer, Jozine M. Ter Maaten, Christopher M. O’Connor, Marco Metra, Howard C. Dittrich, et al. “Trajectories of Changes in Renal Function in Patients with Acute Heart Failure.” J Card Fail 25, no. 11 (November 2019): 866–74. https://doi.org/10.1016/j.cardfail.2019.07.004.
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  - Beusekamp, Joost C., Jasper Tromp, John G. F. Cleland, Michael M. Givertz, Marco Metra, Christopher M. O’Connor, John R. Teerlink, et al. “Hyperkalemia and Treatment With RAAS Inhibitors During Acute Heart Failure Hospitalizations and Their Association With Mortality.” Jacc Heart Fail 7, no. 11 (November 2019): 970–79. https://doi.org/10.1016/j.jchf.2019.07.010.
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  - Greene, Stephen J., Adam D. DeVore, Shubin Sheng, Gregg C. Fonarow, Javed Butler, Robert M. Califf, Adrian F. Hernandez, et al. “Representativeness of a Heart Failure Trial by Race and Sex: Results From ASCEND-HF and GWTG-HF.” Jacc Heart Fail 7, no. 11 (November 2019): 980–92. https://doi.org/10.1016/j.jchf.2019.07.011.
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  - O’Connor, Christopher M. “A Call for Change: Level of Statistical Significance.” Jacc Heart Fail 7, no. 11 (November 2019): 993–94. https://doi.org/10.1016/j.jchf.2019.09.005.
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  - Psotka, Mitchell A., Mona Fiuzat, Peter E. Carson, David P. Kao, Jeffrey Cerkvenik, Daniel E. Schaber, Patrick Verta, et al. “Design of a "Lean" Case Report Form for Heart Failure Therapeutic Development.” Jacc Heart Fail 7, no. 11 (November 2019): 913–21. https://doi.org/10.1016/j.jchf.2019.07.001.
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  - Truesdell, Alexander G., Behnam Tehrani, Carolyn Rosner, Ramesh Singh, Shashank Sinha, Mehul Desai, Shashank Desai, et al. “After Action Reviews.” J Invasive Cardiol 31, no. 11 (November 2019): E341.
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  - O’Connor, Christopher M. “Acute Decompensated Heart Failure: Is There a Path Forward?” Jacc Heart Fail 7, no. 10 (October 2019): 911–12. https://doi.org/10.1016/j.jchf.2019.08.005.
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  - DeVore, Adam D., Eric Yow, Mitchell W. Krucoff, Matthew W. Sherwood, Linda K. Shaw, Karen Chiswell, Christopher M. O’Connor, Erik Magnus Ohman, and Eric J. Velazquez. “Percutaneous coronary intervention outcomes in patients with stable coronary disease and left ventricular systolic dysfunction.” Esc Heart Fail, September 27, 2019. https://doi.org/10.1002/ehf2.12510.
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  - Januzzi, James L., Tariq Ahmad, Hillary Mulder, Adrian Coles, Kevin J. Anstrom, Kirkwood F. Adams, Justin A. Ezekowitz, et al. “Natriuretic Peptide Response and Outcomes in Chronic Heart Failure With Reduced Ejection Fraction.” J Am Coll Cardiol 74, no. 9 (September 3, 2019): 1205–17. https://doi.org/10.1016/j.jacc.2019.06.055.
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  - O’Connor, Christopher M. “Heart Failure Physician Burnout: How Can We Help?” Jacc Heart Fail 7, no. 9 (September 2019): 821. https://doi.org/10.1016/j.jchf.2019.07.004.
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  - Felker, G Michael, Maria Borentain, John G. Cleland, Mary M. DeSouza, Paul D. Kessler, Christopher M. O’Connor, Dietmar Seiffert, John R. Teerlink, Adriaan A. Voors, and John J. V. McMurray. “Rationale and design for the development of a novel nitroxyl donor in patients with acute heart failure.” Eur J Heart Fail 21, no. 8 (August 2019): 1022–31. https://doi.org/10.1002/ejhf.1504.
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  - O’Connor, Christopher M. “Why Should We Publish All Clinical Trials?” Jacc Heart Fail 7, no. 8 (August 2019): 730. https://doi.org/10.1016/j.jchf.2019.06.009.
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  - Warraich, Haider J., Christopher M. O’Connor, Hongqiu Yang, Bradi B. Granger, Kimberly S. Johnson, Daniel B. Mark, Kevin J. Anstrom, et al. “African Americans With Advanced Heart Failure Are More Likely to Die in a Health Care Facility Than at Home or in Hospice: An Analysis From the PAL-HF Trial.” J Card Fail 25, no. 8 (August 2019): 693–94. https://doi.org/10.1016/j.cardfail.2019.05.013.
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  - Tehrani, Behnam N., and Christopher M. O’Connor. “Reply: Standardized and Tailored Approach to Therapies for Cardiogenic Shock.” J Am Coll Cardiol 74, no. 4 (July 30, 2019): 593–94. https://doi.org/10.1016/j.jacc.2019.05.039.
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  - O’Connor, Christopher M. “N-of-1 Clinical Trials.” Jacc Heart Fail 7, no. 7 (July 2019): 630–31. https://doi.org/10.1016/j.jchf.2019.05.004.
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  - Ambrosy, Andrew P., Robert J. Mentz, Mona Fiuzat, John G. F. Cleland, Stephen J. Greene, Christopher M. O’Connor, John R. Teerlink, Faiez Zannad, and Scott D. Solomon. “Erratum to 'The role of angiotensin receptor-neprilysin inhibitors in cardiovascular disease-existing evidence, knowledge gaps, and future directions' [Eur J Heart Fail 2018;20:963-972].” Eur J Heart Fail 21, no. 6 (June 2019): 819. https://doi.org/10.1002/ejhf.1480.
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  - Blumenthal, James A., Yidan Zhu, Gary G. Koch, Patrick J. Smith, Lana L. Watkins, Alan L. Hinderliter, Benson M. Hoffman, et al. “The modifying effects of social support on psychological outcomes in patients with heart failure.” Health Psychol 38, no. 6 (June 2019): 502–8. https://doi.org/10.1037/hea0000716.
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  - O’Connor, Christopher M. “Better Quality of Life Over More Quantity of Life: How We View Time Trade-Off.” Jacc Heart Fail 7, no. 6 (June 2019): 531–32. https://doi.org/10.1016/j.jchf.2019.05.001.
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  - O’Connor, Christopher, Mona Fiuzat, Hillary Mulder, Adrian Coles, Tariq Ahmad, Justin A. Ezekowitz, Kirkwood F. Adams, et al. “Clinical factors related to morbidity and mortality in high-risk heart failure patients: the GUIDE-IT predictive model and risk score.” Eur J Heart Fail 21, no. 6 (June 2019): 770–78. https://doi.org/10.1002/ejhf.1450.
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  - Butler, Javed, Carolyn S. P. Lam, Kevin J. Anstrom, Justin Ezekowitz, Adrian F. Hernandez, Christopher M. O’Connor, Burkert Pieske, et al. “Rationale and Design of the VITALITY-HFpEF Trial.” Circ Heart Fail 12, no. 5 (May 2019): e005998. https://doi.org/10.1161/CIRCHEARTFAILURE.119.005998.
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  - O’Connor, Christopher M. “Guideline-Directed Medical Therapy Clinics: A Call to Action for the Heart Failure Team.” Jacc Heart Fail 7, no. 5 (May 2019): 442–43. https://doi.org/10.1016/j.jchf.2019.04.001.
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  - Psotka, Mitchell A., Susan E. Ammon, Mona Fiuzat, Biykem Bozkurt, Eugene S. Chung, Robert T. Cole, Stephen J. Greene, et al. “Heart Failure Site-Based Research in the United States: Results of the Heart Failure Society of America Research Network Survey.” Jacc Heart Fail 7, no. 5 (May 2019): 431–38. https://doi.org/10.1016/j.jchf.2019.02.008.
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  - Russell, Frances M., Robert R. Ehrman, Robinson Ferre, Luna Gargani, Vicki Noble, Jordan Rupp, Sean P. Collins, et al. “Design and rationale of the B-lines lung ultrasound guided emergency department management of acute heart failure (BLUSHED-AHF) pilot trial.” Heart Lung 48, no. 3 (May 2019): 186–92. https://doi.org/10.1016/j.hrtlng.2018.10.027.
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  - Taylor, Rod S., Sarah Walker, Neil A. Smart, Massimo F. Piepoli, Fiona C. Warren, Oriana Ciani, David Whellan, et al. “Impact of Exercise Rehabilitation on Exercise Capacity and Quality-of-Life in Heart Failure: Individual Participant Meta-Analysis.” J Am Coll Cardiol 73, no. 12 (April 2, 2019): 1430–43. https://doi.org/10.1016/j.jacc.2018.12.072.
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  - O’Connor, Christopher M. “Heart Failure Fake News: How Do We Distinguish the Truth?” Jacc Heart Fail 7, no. 4 (April 2019): 363. https://doi.org/10.1016/j.jchf.2019.02.004.
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  - Lindenfeld, JoAnn, and Christopher M. O’Connor. “Heart Failure in Women.” Jacc Heart Fail 7, no. 3 (March 2019): 274–75. https://doi.org/10.1016/j.jchf.2019.01.012.
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  - Vaduganathan, Muthiah, Ayman Samman Tahhan, Alaaeddin Alrohaibani, Stephen J. Greene, Gregg C. Fonarow, Orly Vardeny, JoAnn Lindenfeld, et al. “Do Women and Men Respond Similarly to Therapies in Contemporary Heart Failure Clinical Trials?” Jacc Heart Fail 7, no. 3 (March 2019): 267–71. https://doi.org/10.1016/j.jchf.2018.12.016.
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  - Daubert, Melissa A., Kirkwood Adams, Eric Yow, Huiman X. Barnhart, Pamela S. Douglas, Susan Rimmer, Casey Norris, et al. “NT-proBNP Goal Achievement Is Associated With Significant Reverse Remodeling and Improved Clinical Outcomes in HFrEF.” Jacc Heart Fail 7, no. 2 (February 2019): 158–68. https://doi.org/10.1016/j.jchf.2018.10.014.
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  - O’Connor, Christopher M. “Recognizing Heart Failure Awareness Week.” Jacc Heart Fail 7, no. 2 (February 2019): 173. https://doi.org/10.1016/j.jchf.2018.12.013.
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  - Luo, Nancy, Christopher M. O’Connor, Lauren B. Cooper, Jie-Lena Sun, Adrian Coles, Shelby D. Reed, David J. Whellan, Ileana L. Piña, William E. Kraus, and Robert J. Mentz. “Relationship between changing patient-reported outcomes and subsequent clinical events in patients with chronic heart failure: insights from HF-ACTION.” Eur J Heart Fail 21, no. 1 (January 2019): 63–70. https://doi.org/10.1002/ejhf.1299.
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  - O’Connor, Christopher M. “JACC: Heart Failure Peer Review Hall of Fame 2018.” Jacc Heart Fail 7, no. 1 (January 2019): 81. https://doi.org/10.1016/j.jchf.2018.12.001.
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  - Piccini, Jonathan P., Sean D. Pokorney, Kevin J. Anstrom, Olaf Oldenburg, Naresh M. Punjabi, Mona Fiuzat, Gudaye Tasissa, et al. “Adaptive servo-ventilation reduces atrial fibrillation burden in patients with heart failure and sleep apnea.” Heart Rhythm 16, no. 1 (January 2019): 91–97. https://doi.org/10.1016/j.hrthm.2018.07.027.
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  - O’Connor, Christopher M. “Aviation Emergencies for Heart Failure Cardiologists: A New Twist to the Heart Team.” Jacc Heart Fail 6, no. 12 (December 2018): 1047–48. https://doi.org/10.1016/j.jchf.2018.10.018.
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  - Taylor, Rod S., Sarah Walker, Neil A. Smart, Massimo F. Piepoli, Fiona C. Warren, Oriana Ciani, Christopher O’Connor, et al. “Impact of exercise-based cardiac rehabilitation in patients with heart failure (ExTraMATCH II) on mortality and hospitalisation: an individual patient data meta-analysis of randomised trials.” Eur J Heart Fail 20, no. 12 (December 2018): 1735–43. https://doi.org/10.1002/ejhf.1311.
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  - Mark, Daniel B., Patricia A. Cowper, Kevin J. Anstrom, Shubin Sheng, Melanie R. Daniels, J David Knight, Khaula N. Baloch, et al. “Economic and Quality-of-Life Outcomes of Natriuretic Peptide-Guided Therapy for Heart Failure.” J Am Coll Cardiol 72, no. 21 (November 27, 2018): 2551–62. https://doi.org/10.1016/j.jacc.2018.08.2184.
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  - Fudim, Marat, Christopher M. O’Connor, Hillary Mulder, Adrian Coles, Ankeet S. Bhatt, Andrew P. Ambrosy, William E. Kraus, Ileana L. Piña, David J. Whellan, and Robert J. Mentz. “Loop diuretic adjustments in patients with chronic heart failure: Insights from HF-ACTION.” Am Heart J 205 (November 2018): 133–41. https://doi.org/10.1016/j.ahj.2018.06.017.
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  - Fudim, Marat, Kishan S. Parikh, Allison Dunning, Adam D. DeVore, Robert J. Mentz, Phillip J. Schulte, Paul W. Armstrong, et al. “Relation of Volume Overload to Clinical Outcomes in Acute Heart Failure (From ASCEND-HF).” Am J Cardiol 122, no. 9 (November 1, 2018): 1506–12. https://doi.org/10.1016/j.amjcard.2018.07.023.
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  - Hamo, Carine E., Christopher O’Connor, Marco Metra, James E. Udelson, Mihai Gheorghiade, and Javed Butler. “A Critical Appraisal of Short-Term End Points in Acute Heart Failure Clinical Trials.” J Card Fail 24, no. 11 (November 2018): 783–92. https://doi.org/10.1016/j.cardfail.2018.08.007.
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  - O’Connor, Christopher M. “COAPTing Heart Failure Physicians, Interventional Cardiologists, and CardioThoracic Surgeons: A New Opportunity for Patients.” Jacc Heart Fail 6, no. 11 (November 2018): 967–68. https://doi.org/10.1016/j.jchf.2018.09.007.
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  - Fudim, Marat, Rahul Loungani, Shannon M. Doerfler, Adrian Coles, Stephen J. Greene, Lauren B. Cooper, Mona Fiuzat, Christopher M. O’Connor, Joseph G. Rogers, and Robert J. Mentz. “Worsening renal function during decongestion among patients hospitalized for heart failure: Findings from the Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness (ESCAPE) trial.” Am Heart J 204 (October 2018): 163–73. https://doi.org/10.1016/j.ahj.2018.07.019.
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  - Greene, Stephen J., Adrian F. Hernandez, Jie-Lena Sun, Javed Butler, Paul W. Armstrong, Justin A. Ezekowitz, Faiez Zannad, et al. “Relationship Between Enrolling Country Income Level and Patient Profile, Protocol Completion, and Trial End Points.” Circ Cardiovasc Qual Outcomes 11, no. 10 (October 2018): e004783. https://doi.org/10.1161/CIRCOUTCOMES.118.004783.
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  - Jiang, Wei, David J. Whellan, Kirkwood F. Adams, Michael A. Babyak, Stephen H. Boyle, Jennifer L. Wilson, Chetan B. Patel, Joseph G. Rogers, William S. Harris, and Christopher M. O’Connor. “Long-Chain Omega-3 Fatty Acid Supplements in Depressed Heart Failure Patients: Results of the OCEAN Trial.” Jacc Heart Fail 6, no. 10 (October 2018): 833–43. https://doi.org/10.1016/j.jchf.2018.03.011.
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  - O’Connor, Christopher M. “Depression in Heart Failure: Beyond a SADHART.” Jacc Heart Fail 6, no. 10 (October 2018): 885–86. https://doi.org/10.1016/j.jchf.2018.08.004.
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  - Sharma, Abhinav, Lauren B. Cooper, Mona Fiuzat, Robert J. Mentz, João Pedro Ferreira, Javed Butler, David Fitchett, Alan Charles Moses, Christopher O’Connor, and Faiez Zannad. “Antihyperglycemic Therapies to Treat Patients With Heart Failure and Diabetes Mellitus.” Jacc Heart Fail 6, no. 10 (October 2018): 813–22. https://doi.org/10.1016/j.jchf.2018.05.020.
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  - Tahhan, Ayman Samman, Muthiah Vaduganathan, Stephen J. Greene, Gregg C. Fonarow, Mona Fiuzat, Mariell Jessup, JoAnn Lindenfeld, Christopher M. O’Connor, and Javed Butler. “Enrollment of Older Patients, Women, and Racial and Ethnic Minorities in Contemporary Heart Failure Clinical Trials: A Systematic Review.” Jama Cardiol 3, no. 10 (October 1, 2018): 1011–19. https://doi.org/10.1001/jamacardio.2018.2559.
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  - Ambrosy, Andrew P., Hillary Mulder, Adrian Coles, William E. Krauss, Carolyn S. P. Lam, Peter A. McCullough, Ileana Pina, et al. “Renal Function and Exercise Training in AmbulatoryHeart Failure Patients With a Reduced Ejection Fraction.” Am J Cardiol 122, no. 6 (September 15, 2018): 999–1007. https://doi.org/10.1016/j.amjcard.2018.06.011.
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  - Greene, Stephen J., Robert J. Mentz, Mona Fiuzat, Javed Butler, Scott D. Solomon, Andrew P. Ambrosy, Cyrus Mehta, John R. Teerlink, Faiez Zannad, and Christopher M. O’Connor. “Reassessing the Role of Surrogate End Points in Drug Development for Heart Failure.” Circulation 138, no. 10 (September 4, 2018): 1039–53. https://doi.org/10.1161/CIRCULATIONAHA.118.034668.
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  - Cooper, Lauren B., Jonathan Yap, Wan Ting Tay, Tiew-Hwa K. Teng, Michael MacDonald, Inder S. Anand, Abhinav Sharma, et al. “Multi-ethnic comparisons of diabetes in heart failure with reduced ejection fraction: insights from the HF-ACTION trial and the ASIAN-HF registry.” Eur J Heart Fail 20, no. 9 (September 2018): 1281–89. https://doi.org/10.1002/ejhf.1223.
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  - O’Connor, Christopher M. “Politically Correct Heart Failure Research in America to Avoid Geographic Variation.” Jacc Heart Fail 6, no. 9 (September 2018): 805–6. https://doi.org/10.1016/j.jchf.2018.07.010.
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  - Grodin, Justin L., Javed Butler, Marco Metra, G Michael Felker, Adriaan A. Voors, John J. McMurray, Paul W. Armstrong, et al. “Circulating Cardiac Troponin I Levels Measured by a Novel Highly Sensitive Assay in Acute Decompensated Heart Failure: Insights From the ASCEND-HF Trial.” J Card Fail 24, no. 8 (August 2018): 512–19. https://doi.org/10.1016/j.cardfail.2018.06.008.
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  - O’Connor, Christopher M. “HFpEF: From Early Observations to Worldwide Awareness.” Jacc Heart Fail 6, no. 8 (August 2018): 718–19. https://doi.org/10.1016/j.jchf.2018.07.001.
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  - Parikh, Kishan S., Kavita Sharma, Mona Fiuzat, Howard K. Surks, Jyothis T. George, Narimon Honarpour, Christopher Depre, et al. “Heart Failure With Preserved Ejection Fraction Expert Panel Report: Current Controversies and Implications for Clinical Trials.” Jacc Heart Fail 6, no. 8 (August 2018): 619–32. https://doi.org/10.1016/j.jchf.2018.06.008.
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  - Parikh, Kishan S., Mona Fiuzat, Gordon Davis, Megan Neely, Penny Blain-Nelson, David J. Whellan, William T. Abraham, et al. “Dose Response of β-Blockers in Adrenergic Receptor Polymorphism Genotypes.” Circ Genom Precis Med 11, no. 8 (August 2018): e002210. https://doi.org/10.1161/CIRCGEN.117.002210.
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  - Vaduganathan, Muthiah, Ravi B. Patel, Robert J. Mentz, Haris Subacius, Neal A. Chatterjee, Stephen J. Greene, Andrew P. Ambrosy, et al. “Sudden Death After Hospitalization for Heart Failure With Reduced Ejection Fraction (from the EVEREST Trial).” Am J Cardiol 122, no. 2 (July 15, 2018): 255–60. https://doi.org/10.1016/j.amjcard.2018.03.362.
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  - Daubert, Melissa A., David J. Whellan, Holger Woehrle, Gudaye Tasissa, Kevin J. Anstrom, JoAnn Lindenfeld, Adam Benjafield, et al. “Treatment of sleep-disordered breathing in heart failure impacts cardiac remodeling: Insights from the CAT-HF Trial.” Am Heart J 201 (July 2018): 40–48. https://doi.org/10.1016/j.ahj.2018.03.026.
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  - O’Connor, Christopher M. “Cardiovascular Drug Pricing: Less Innovation for More Access?” Jacc Heart Fail 6, no. 7 (July 2018): 613–14. https://doi.org/10.1016/j.jchf.2018.05.016.
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  - Warraich, Haider J., Christopher O’Connor, Angie Wu, Adrian Coles, William E. Kraus, Ileana L. Piña, David J. Whellan, and Robert J. Mentz. “Differences Between Patients Enrolled Early and Late During Clinical Trial Recruitment: Insights From the HF-ACTION Trial.” Circ Cardiovasc Qual Outcomes 11, no. 7 (July 2018): e004643. https://doi.org/10.1161/CIRCOUTCOMES.117.004643.
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  - Ambrosy, Andrew P., Robert J. Mentz, Mona Fiuzat, John G. F. Cleland, Stephen J. Greene, Christopher M. O’Connor, John R. Teerlink, Faiez Zannad, and Scott D. Solomon. “The role of angiotensin receptor-neprilysin inhibitors in cardiovascular disease-existing evidence, knowledge gaps, and future directions.” Eur J Heart Fail 20, no. 6 (June 2018): 963–72. https://doi.org/10.1002/ejhf.1159.
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  - O’Connor, Christopher M. “Dying With Dignity and Heart Failure: A Lesson From Barbara Bush.” Jacc Heart Fail 6, no. 6 (June 2018): 536–37. https://doi.org/10.1016/j.jchf.2018.04.011.
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  - Ahmad, Tariq, Keyanna Jackson, Veena S. Rao, WH Wilson Tang, Meredith A. Brisco-Bacik, Horng H. Chen, G Michael Felker, et al. “Worsening Renal Function in Patients With Acute Heart Failure Undergoing Aggressive Diuresis Is Not Associated With Tubular Injury.” Circulation 137, no. 19 (May 8, 2018): 2016–28. https://doi.org/10.1161/CIRCULATIONAHA.117.030112.
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  - Ambrosy, Andrew P., Ankeet S. Bhatt, Amanda L. Stebbins, Lisa M. Wruck, Marat Fudim, Stephen J. Greene, William E. Kraus, et al. “Prevalent digoxin use and subsequent risk of death or hospitalization in ambulatory heart failure patients with a reduced ejection fraction-Findings from the Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) randomized controlled trial.” Am Heart J 199 (May 2018): 97–104. https://doi.org/10.1016/j.ahj.2018.02.004.
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  - Metra, Marco, Gad Cotter, Stefanie Senger, Christopher Edwards, John G. Cleland, Piotr Ponikowski, Guillermo C. Cursack, et al. “Prognostic Significance of Creatinine Increases During an Acute Heart Failure Admission in Patients With and Without Residual Congestion: A Post Hoc Analysis of the PROTECT Data.” Circ Heart Fail 11, no. 5 (May 2018): e004644. https://doi.org/10.1161/CIRCHEARTFAILURE.117.004644.
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  - O’Connor, Christopher M. “What's One More Day?” Jacc Heart Fail 6, no. 5 (May 2018): 438. https://doi.org/10.1016/j.jchf.2018.03.015.
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  - Rubio-Gracia, Jorge, Biniyam G. Demissei, Jozine M. Ter Maaten, John G. Cleland, Christopher M. O’Connor, Marco Metra, Piotr Ponikowski, et al. “Prevalence, predictors and clinical outcome of residual congestion in acute decompensated heart failure.” Int J Cardiol 258 (May 1, 2018): 185–91. https://doi.org/10.1016/j.ijcard.2018.01.067.
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  - Ahmad, Tariq, Lars H. Lund, Pooja Rao, Rohit Ghosh, Prashant Warier, Benjamin Vaccaro, Ulf Dahlström, Christopher M. O’Connor, G Michael Felker, and Nihar R. Desai. “Machine Learning Methods Improve Prognostication, Identify Clinically Distinct Phenotypes, and Detect Heterogeneity in Response to Therapy in a Large Cohort of Heart Failure Patients.” J Am Heart Assoc 7, no. 8 (April 12, 2018). https://doi.org/10.1161/JAHA.117.008081.
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  - Cerbin, Lukasz P., Andrew P. Ambrosy, Stephen J. Greene, Paul W. Armstrong, Javed Butler, Adrian Coles, Adam D. DeVore, et al. “Is Time of the Essence? The Impact of Time of Hospital Presentation in Acute Heart Failure: Insights From ASCEND-HF Trial.” Jacc Heart Fail 6, no. 4 (April 2018): 298–307. https://doi.org/10.1016/j.jchf.2018.01.018.
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  - O’Connor, Christopher M., and Michael R. Bristow. “Changing the Research Culture in the United States.” Jacc Heart Fail 6, no. 4 (April 2018): 344–45. https://doi.org/10.1016/j.jchf.2018.03.001.
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  - Hicks, Karen A., Kenneth W. Mahaffey, Roxana Mehran, Steven E. Nissen, Stephen D. Wiviott, Billy Dunn, Scott D. Solomon, et al. “2017 Cardiovascular and Stroke Endpoint Definitions for Clinical Trials.” J Am Coll Cardiol 71, no. 9 (March 6, 2018): 1021–34. https://doi.org/10.1016/j.jacc.2017.12.048.
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  - O’Connor, Christopher M. “Heart Failure Health Care 2018: Challenges and Opportunities.” Jacc Heart Fail 6, no. 3 (March 2018): 262–63. https://doi.org/10.1016/j.jchf.2018.01.013.
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  - Hicks, Karen A., Kenneth W. Mahaffey, Roxana Mehran, Steven E. Nissen, Stephen D. Wiviott, Billy Dunn, Scott D. Solomon, et al. “2017 Cardiovascular and Stroke Endpoint Definitions for Clinical Trials.” Circulation 137, no. 9 (February 27, 2018): 961–72. https://doi.org/10.1161/CIRCULATIONAHA.117.033502.
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  - Bhatt, Ankeet S., Lauren B. Cooper, Andrew P. Ambrosy, Robert M. Clare, Adrian Coles, Emer Joyce, Arun Krishnamoorthy, et al. “Interaction of Body Mass Index on the Association Between N-Terminal-Pro-b-Type Natriuretic Peptide and Morbidity and Mortality in Patients With Acute Heart Failure: Findings From ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure).” J Am Heart Assoc 7, no. 3 (February 3, 2018). https://doi.org/10.1161/JAHA.117.006740.
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  - Armstrong, Paul W., Lothar Roessig, Mahesh J. Patel, Kevin J. Anstrom, Javed Butler, Adriaan A. Voors, Carolyn S. P. Lam, et al. “A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of the Efficacy and Safety of the Oral Soluble Guanylate Cyclase Stimulator: The VICTORIA Trial.” Jacc Heart Fail 6, no. 2 (February 2018): 96–104. https://doi.org/10.1016/j.jchf.2017.08.013.
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  - Cotter, Gad, Marco Metra, Beth A. Davison, Guillaume Jondeau, John G. F. Cleland, Robert C. Bourge, Olga Milo, et al. “Systolic blood pressure reduction during the first 24 h in acute heart failure admission: friend or foe?” Eur J Heart Fail 20, no. 2 (February 2018): 317–22. https://doi.org/10.1002/ejhf.889.
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  - Fudim, Marat, Christopher M. O’Connor, Allison Dunning, Andrew P. Ambrosy, Paul W. Armstrong, Adrian Coles, Justin A. Ezekowitz, et al. “Aetiology, timing and clinical predictors of early vs. late readmission following index hospitalization for acute heart failure: insights from ASCEND-HF.” Eur J Heart Fail 20, no. 2 (February 2018): 304–14. https://doi.org/10.1002/ejhf.1020.
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  - O’Connor, Christopher M. “Smartphone, Mom, and HFpEF.” Jacc Heart Fail 6, no. 2 (February 2018): 176. https://doi.org/10.1016/j.jchf.2017.12.010.
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  - O’Connor, Christopher M., Mitchell A. Psotka, Mona Fiuzat, JoAnn Lindenfeld, William T. Abraham, Michael R. Bristow, Daniel Canos, et al. “Improving Heart Failure Therapeutics Development in the United States: The Heart Failure Collaboratory.” J Am Coll Cardiol 71, no. 4 (January 30, 2018): 443–53. https://doi.org/10.1016/j.jacc.2017.11.048.
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  - O’Connor, Christopher M. “I Don't Care How Low My BNP Is, I Want to Feel Good.” Jacc Heart Fail 6, no. 1 (January 2018): 82–83. https://doi.org/10.1016/j.jchf.2017.11.004.
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  - Pastva, Amy M., Pamela W. Duncan, Gordon R. Reeves, M Benjamin Nelson, David J. Whellan, Christopher M. O’Connor, Joel D. Eggebeen, et al. “Strategies for supporting intervention fidelity in the rehabilitation therapy in older acute heart failure patients (REHAB-HF) trial.” Contemp Clin Trials 64 (January 2018): 118–27. https://doi.org/10.1016/j.cct.2017.10.014.
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  - Daubert, Melissa A., Eric Yow, Gary Dunn, Sotir Marchev, Huiman Barnhart, Pamela S. Douglas, Christopher O’Connor, Sidney Goldstein, James E. Udelson, and Hani N. Sabbah. “Novel Mitochondria-Targeting Peptide in Heart Failure Treatment: A Randomized, Placebo-Controlled Trial of Elamipretide.” Circ Heart Fail 10, no. 12 (December 2017). https://doi.org/10.1161/CIRCHEARTFAILURE.117.004389.
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  - Alenezi, Fawaz, Beverly H. Brummett, Stephen H. Boyle, Zainab Samad, Michael A. Babyak, Nabil Alzaeim, Jennifer Wilson, et al. “Usefulness of Myocardial Annular Velocity Change During Mental Stress to Predict Cardiovascular Outcome in Patients With Coronary Artery Disease (From the Responses of Mental Stress-Induced Myocardial Ischemia to Escitalopram Treatment Trial).” Am J Cardiol 120, no. 9 (November 1, 2017): 1495–1500. https://doi.org/10.1016/j.amjcard.2017.07.039.
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  - O’Connor, Christopher M. “Goodbye Mihai: We Will Miss You.” Jacc Heart Fail 5, no. 11 (November 2017): 848–49. https://doi.org/10.1016/j.jchf.2017.09.007.
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  - O’Connor, Christopher M. “Q&A With the JACC: Heart Failure Editor-in-Chief: Marking the 5-Year Milestone.” Jacc Heart Fail 5, no. 10 (October 2017): 758–59. https://doi.org/10.1016/j.jchf.2017.08.006.
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  - Sharma, Abhinav, Biniyam G. Demissei, Jasper Tromp, Hans L. Hillege, John G. Cleland, Christopher M. O’Connor, Marco Metra, et al. “A network analysis to compare biomarker profiles in patients with and without diabetes mellitus in acute heart failure.” Eur J Heart Fail 19, no. 10 (October 2017): 1310–20. https://doi.org/10.1002/ejhf.912.
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  - Sharma, Abhinav, Susanna R. Stevens, Joseph Lucas, Mona Fiuzat, Kirkwood F. Adams, David J. Whellan, Mark P. Donahue, et al. “Utility of Growth Differentiation Factor-15, A Marker of Oxidative Stress and Inflammation, in Chronic Heart Failure: Insights From the HF-ACTION Study.” Jacc Heart Fail 5, no. 10 (October 2017): 724–34. https://doi.org/10.1016/j.jchf.2017.07.013.
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  - Luo, Nancy, Tiew-Hwa Katherine Teng, Wan Ting Tay, Inder S. Anand, William E. Kraus, Houng Bang Liew, Lieng Hsi Ling, et al. “Multinational and multiethnic variations in health-related quality of life in patients with chronic heart failure.” Am Heart J 191 (September 2017): 75–81. https://doi.org/10.1016/j.ahj.2017.06.016.
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  - O’Connor, Christopher M. “America and Apple Pie: How Do We Change the American Health Care System?” Jacc Heart Fail 5, no. 9 (September 2017): 686–87. https://doi.org/10.1016/j.jchf.2017.07.006.
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  - Sherwood, Andrew, LaBarron K. Hill, James A. Blumenthal, Kirkwood F. Adams, Nicola J. Paine, Gary G. Koch, Christopher M. O’Connor, Kristy S. Johnson, and Alan L. Hinderliter. “Blood pressure reactivity to psychological stress is associated with clinical outcomes in patients with heart failure.” Am Heart J 191 (September 2017): 82–90. https://doi.org/10.1016/j.ahj.2017.07.003.
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  - O’Connor, Christopher M. “Does Institutional Memory Matter?” Jacc Heart Fail 5, no. 8 (August 2017): 616. https://doi.org/10.1016/j.jchf.2017.07.001.
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  - Rogers, Joseph G., Chetan B. Patel, Robert J. Mentz, Bradi B. Granger, Karen E. Steinhauser, Mona Fiuzat, Patricia A. Adams, et al. “Palliative Care in Heart Failure: The PAL-HF Randomized, Controlled Clinical Trial.” J Am Coll Cardiol 70, no. 3 (July 18, 2017): 331–41. https://doi.org/10.1016/j.jacc.2017.05.030.
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  - O’Connor, Christopher M. “A Decade With Editorial Mentors: The Day They Dropped the Mic.” Jacc Heart Fail 5, no. 7 (July 2017): 541–42. https://doi.org/10.1016/j.jchf.2017.05.009.
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  - Tromp, Jasper, Mohsin A. F. Khan, Robert J. Mentz, Christopher M. O’Connor, Marco Metra, Howard C. Dittrich, Piotr Ponikowski, et al. “Biomarker Profiles of Acute Heart Failure Patients With a Mid-Range Ejection Fraction.” Jacc Heart Fail 5, no. 7 (July 2017): 507–17. https://doi.org/10.1016/j.jchf.2017.04.007.
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  - Greene, Stephen J., Adrian F. Hernandez, Allison Dunning, Andrew P. Ambrosy, Paul W. Armstrong, Javed Butler, Lukasz P. Cerbin, et al. “Hospitalization for Recently Diagnosed Versus Worsening Chronic Heart Failure: From the ASCEND-HF Trial.” J Am Coll Cardiol 69, no. 25 (June 27, 2017): 3029–39. https://doi.org/10.1016/j.jacc.2017.04.043.
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  - Banks, Adam, Samuel Broderick, Karen Chiswell, Linda Shaw, Adam Devore, Mona Fiuzat, Christopher O’Connor, Gary Michael Felker, Eric Velazquez, and Robert Mentz. “Comparison of Clinical Characteristics and Outcomes of Patients With Versus Without Diabetes Mellitus and With Versus Without Angina Pectoris (from the Duke Databank for Cardiovascular Disease).” Am J Cardiol 119, no. 11 (June 1, 2017): 1703–9. https://doi.org/10.1016/j.amjcard.2017.02.053.
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  - Cleland, John G. F., John R. Teerlink, Beth A. Davison, Ahmad Shoaib, Marco Metra, Stefanie Senger, Olga Milo, et al. “Measurement of troponin and natriuretic peptides shortly after admission in patients with heart failure-does it add useful prognostic information? An analysis of the Value of Endothelin Receptor Inhibition with Tezosentan in Acute heart failure Studies (VERITAS).” Eur J Heart Fail 19, no. 6 (June 2017): 739–47. https://doi.org/10.1002/ejhf.786.
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  - Demissei, Biniyam G., Douwe Postmus, John G. Cleland, Christopher M. O’Connor, Marco Metra, Piotr Ponikowski, John R. Teerlink, et al. “Plasma biomarkers to predict or rule out early post-discharge events after hospitalization for acute heart failure.” Eur J Heart Fail 19, no. 6 (June 2017): 728–38. https://doi.org/10.1002/ejhf.766.
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  - O’Connor, Christopher M. “Development of Acute Decompensated Heart Failure Therapies: Is the Journey Over?” Jacc Heart Fail 5, no. 6 (June 2017): 464–65. https://doi.org/10.1016/j.jchf.2017.04.010.
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  - Raslan, Ismail R., Paul Brown, Cynthia M. Westerhout, Justin A. Ezekowitz, Adrian F. Hernandez, Randall C. Starling, Christopher O’Connor, et al. “Characterization of hemodynamically stable acute heart failure patients requiring a critical care unit admission: Derivation, validation, and refinement of a risk score.” Am Heart J 188 (June 2017): 127–35. https://doi.org/10.1016/j.ahj.2017.03.014.
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  - Packer, Milton, Christopher O’Connor, John J. V. McMurray, Janet Wittes, William T. Abraham, Stefan D. Anker, Kenneth Dickstein, et al. “Effect of Ularitide on Cardiovascular Mortality in Acute Heart Failure.” N Engl J Med 376, no. 20 (May 18, 2017): 1956–64. https://doi.org/10.1056/NEJMoa1601895.
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  - O’Connor, Christopher M. “High Heart Failure Readmission Rates: Is It the Health System's Fault?” Jacc Heart Fail 5, no. 5 (May 2017): 393. https://doi.org/10.1016/j.jchf.2017.03.011.
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  - Packer, Milton, Richard Holcomb, William T. Abraham, Stefan Anker, Kenneth Dickstein, Gerasimos Filippatos, Henry Krum, et al. “Rationale for and design of the TRUE-AHF trial: the effects of ularitide on the short-term clinical course and long-term mortality of patients with acute heart failure.” Eur J Heart Fail 19, no. 5 (May 2017): 673–81. https://doi.org/10.1002/ejhf.698.
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  - Reeves, Gordon R., David J. Whellan, Christopher M. O’Connor, Pamela Duncan, Joel D. Eggebeen, Timothy M. Morgan, Leigh Ann Hewston, Amy Pastva, Mahesh J. Patel, and Dalane W. Kitzman. “A Novel Rehabilitation Intervention for Older Patients With Acute Decompensated Heart Failure: The REHAB-HF Pilot Study.” Jacc Heart Fail 5, no. 5 (May 2017): 359–66. https://doi.org/10.1016/j.jchf.2016.12.019.
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  - Luo, Nancy, Peter Merrill, Kishan S. Parikh, David J. Whellan, Ileana L. Piña, Mona Fiuzat, William E. Kraus, et al. “Exercise Training in Patients With Chronic Heart Failure and Atrial Fibrillation.” J Am Coll Cardiol 69, no. 13 (April 4, 2017): 1683–91. https://doi.org/10.1016/j.jacc.2017.01.032.
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  - Ambrosy, Andrew P., Lukasz P. Cerbin, Adam D. DeVore, Stephen J. Greene, William E. Kraus, Christopher M. O’Connor, Ileana L. Piña, et al. “Aerobic exercise training and general health status in ambulatory heart failure patients with a reduced ejection fraction-Findings from the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION)trial.” Am Heart J 186 (April 2017): 130–38. https://doi.org/10.1016/j.ahj.2016.12.017.
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  - Butler, Javed, Carine E. Hamo, James E. Udelson, Christopher O’Connor, Hani N. Sabbah, Marco Metra, Sanjiv J. Shah, et al. “Reassessing Phase II Heart Failure Clinical Trials: Consensus Recommendations.” Circ Heart Fail 10, no. 4 (April 2017). https://doi.org/10.1161/CIRCHEARTFAILURE.116.003800.
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  - O’Connor, Christopher M., and Dirk J. van Veldhuisen. “Data Sharing From the Editors' Perspective: Our Hope With Limitations.” Jacc Heart Fail 5, no. 4 (April 2017): 314–15. https://doi.org/10.1016/j.jchf.2017.02.007.
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  - Sun, Julia L., Stephen H. Boyle, Zainab Samad, Michael A. Babyak, Jennifer L. Wilson, Cynthia Kuhn, Richard C. Becker, et al. “Mental stress-induced left ventricular dysfunction and adverse outcome in ischemic heart disease patients.” Eur J Prev Cardiol 24, no. 6 (April 2017): 591–99. https://doi.org/10.1177/2047487316686435.
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  - O’Connor, Christopher M., David J. Whellan, Mona Fiuzat, Naresh M. Punjabi, Gudaye Tasissa, Kevin J. Anstrom, Adam V. Benjafield, et al. “Cardiovascular Outcomes With Minute Ventilation-Targeted Adaptive Servo-Ventilation Therapy in Heart Failure: The CAT-HF Trial.” J Am Coll Cardiol 69, no. 12 (March 28, 2017): 1577–87. https://doi.org/10.1016/j.jacc.2017.01.041.
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  - Felker, G Michael, Robert J. Mentz, Robert T. Cole, Kirkwood F. Adams, Gregory F. Egnaczyk, Mona Fiuzat, Chetan B. Patel, et al. “Efficacy and Safety of Tolvaptan in Patients Hospitalized With Acute Heart Failure.” J Am Coll Cardiol 69, no. 11 (March 21, 2017): 1399–1406. https://doi.org/10.1016/j.jacc.2016.09.004.
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  - Levy, Wayne C., Yanhong Li, Shelby D. Reed, Michael R. Zile, Ramin Shadman, Todd Dardas, David J. Whellan, et al. “Does the Implantable Cardioverter-Defibrillator Benefit Vary With the Estimated Proportional Risk of Sudden Death in Heart Failure Patients?” Jacc Clin Electrophysiol 3, no. 3 (March 2017): 291–98. https://doi.org/10.1016/j.jacep.2016.09.006.
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  - Matsue, Yuya, Jozine M. Ter Maaten, Joachim Struck, Marco Metra, Christopher M. O’Connor, Piotr Ponikowski, John R. Teerlink, et al. “Clinical Correlates and Prognostic Value of Proenkephalin in Acute and Chronic Heart Failure.” J Card Fail 23, no. 3 (March 2017): 231–39. https://doi.org/10.1016/j.cardfail.2016.09.007.
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  - Matsue, Yuya, Peter van der Meer, Kevin Damman, Marco Metra, Christopher M. O’Connor, Piotr Ponikowski, John R. Teerlink, et al. “Blood urea nitrogen-to-creatinine ratio in the general population and in patients with acute heart failure.” Heart 103, no. 6 (March 2017): 407–13. https://doi.org/10.1136/heartjnl-2016-310112.
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  - O’Connor, Christopher M. “Is Salt Bad for You?” Jacc Heart Fail 5, no. 3 (March 2017): 238–39. https://doi.org/10.1016/j.jchf.2017.01.003.
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  - Reeves, Gordon R., David J. Whellan, Pamela Duncan, Christopher M. O’Connor, Amy M. Pastva, Joel D. Eggebeen, Leigh Ann Hewston, et al. “Rehabilitation Therapy in Older Acute Heart Failure Patients (REHAB-HF) trial: Design and rationale.” Am Heart J 185 (March 2017): 130–39. https://doi.org/10.1016/j.ahj.2016.12.012.
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  - Feigal, Jacob P., Stephen H. Boyle, Zainab Samad, Eric J. Velazquez, Jennifer L. Wilson, Richard C. Becker, Redford B. Williams, et al. “Associations between positive emotional well-being and stress-induced myocardial ischemia: Well-being scores predict exercise-induced ischemia.” J Psychosom Res 93 (February 2017): 14–18. https://doi.org/10.1016/j.jpsychores.2016.11.012.
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  - Kitai, Takeshi, Justin L. Grodin, Robert J. Mentz, Adrian F. Hernandez, Javed Butler, Marco Metra, John J. McMurray, et al. “Insufficient reduction in heart rate during hospitalization despite beta-blocker treatment in acute decompensated heart failure: insights from the ASCEND-HF trial.” Eur J Heart Fail 19, no. 2 (February 2017): 241–49. https://doi.org/10.1002/ejhf.629.
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  - O’Connor, Christopher M. “21st Century Cures: A Step Forward for Patients With Heart Failure.” Jacc Heart Fail 5, no. 2 (February 2017): 154. https://doi.org/10.1016/j.jchf.2016.12.004.
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  - Tromp, Jasper, Jozine M. Ter Maaten, Kevin Damman, Christopher M. O’Connor, Marco Metra, Howard C. Dittrich, Piotr Ponikowski, et al. “Serum Potassium Levels and Outcome in Acute Heart Failure (Data from the PROTECT and COACH Trials).” Am J Cardiol 119, no. 2 (January 15, 2017): 290–96. https://doi.org/10.1016/j.amjcard.2016.09.038.
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  - Navarese, Eliano P., Paul A. Gurbel, Felicita Andreotti, Michalina Marta Kołodziejczak, Suetonia C. Palmer, Sofia Dias, Antonino Buffon, et al. “Prevention of contrast-induced acute kidney injury in patients undergoing cardiovascular procedures-a systematic review and network meta-analysis.” Plos One 12, no. 2 (2017): e0168726. https://doi.org/10.1371/journal.pone.0168726.
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  - O’Connor, C. “HFSA President's Paper.” Journal of Cardiac Failure, January 1, 2017. https://doi.org/10.1016/j.cardfail.2017.07.399.
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  - O’Connor, Christopher M. “Developing Breakthrough Drugs for Heart Failure: Lessons Learned From the Cystic Fibrosis Experience.” Jacc Heart Fail 5, no. 1 (January 2017): 71–72. https://doi.org/10.1016/j.jchf.2016.11.008.
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  - Sherwood, Andrew, James A. Blumenthal, Gary G. Koch, Benson M. Hoffman, Lana L. Watkins, Patrick J. Smith, Christopher M. O’Connor, et al. “Effects of Coping Skills Training on Quality of Life, Disease Biomarkers, and Clinical Outcomes in Patients With Heart Failure: A Randomized Clinical Trial.” Circ Heart Fail 10, no. 1 (January 2017). https://doi.org/10.1161/CIRCHEARTFAILURE.116.003410.
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  - Streng, Koen W., Jozine M. Ter Maaten, John G. Cleland, Christopher M. O’Connor, Beth A. Davison, Marco Metra, Michael M. Givertz, et al. “Associations of Body Mass Index With Laboratory and Biomarkers in Patients With Acute Heart Failure.” Circ Heart Fail 10, no. 1 (January 2017). https://doi.org/10.1161/CIRCHEARTFAILURE.116.003350.
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  - Verma, Amanda K., Phillip J. Schulte, Vera Bittner, Steven J. Keteyian, Jerome L. Fleg, Ileana L. Piña, Ann M. Swank, et al. “Socioeconomic and partner status in chronic heart failure: Relationship to exercise capacity, quality of life, and clinical outcomes.” Am Heart J 183 (January 2017): 54–61. https://doi.org/10.1016/j.ahj.2016.10.007.
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  - O’Connor, Christopher M. “Not Your Mother's FDA.” Jacc Heart Fail 4, no. 12 (December 2016): 978. https://doi.org/10.1016/j.jchf.2016.10.001.
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  - Vegter, Eline L., Daniela Schmitter, Yanick Hagemeijer, Ekaterina S. Ovchinnikova, Pim van der Harst, John R. Teerlink, Christopher M. O’Connor, et al. “Use of biomarkers to establish potential role and function of circulating microRNAs in acute heart failure.” Int J Cardiol 224 (December 1, 2016): 231–39. https://doi.org/10.1016/j.ijcard.2016.09.010.
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  - Ambrosy, A. P., L. P. Cerbin, P. W. Armstrong, J. Butler, A. Coles, A. D. DeVore, M. E. Dunlap, et al. “Body Weight Change During and After Hospitalization for Acute Heart Failure: Patient Characteristics, Markers of Congestion, and Outcomes: Findings From ASCEND-HF.” Jacc Heart Fail, November 30, 2016. https://doi.org/10.1016/j.jchf.2016.09.012.
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  - Demissei, Biniyam G., Douwe Postmus, Licette C. Y. Liu, John G. Cleland, Christopher M. O’Connor, Marco Metra, Piotr Ponikowski, et al. “Risk-based evaluation of efficacy of rolofylline in patients hospitalized with acute heart failure - Post-hoc analysis of the PROTECT trial.” Int J Cardiol 223 (November 15, 2016): 967–75. https://doi.org/10.1016/j.ijcard.2016.08.271.
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  - O’Connor, Christopher M. “Peer Review of Peer Review: Somewhere Over the Rainbow.” Jacc Heart Fail 4, no. 11 (November 2016): 907–8. https://doi.org/10.1016/j.jchf.2016.09.005.
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  - Parikh, Kishan S., Adrian Coles, Phillip J. Schulte, William E. Kraus, Jerome L. Fleg, Steven J. Keteyian, Ileana L. Piña, et al. “Relation of Angina Pectoris to Outcomes, Quality of Life, and Response to Exercise Training in Patients With Chronic Heart Failure (from HF-ACTION).” Am J Cardiol 118, no. 8 (October 15, 2016): 1211–16. https://doi.org/10.1016/j.amjcard.2016.07.040.
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  - Tromp, Jasper, Sven Meyer, Robert J. Mentz, Christopher M. O’Connor, Marco Metra, Howard C. Dittrich, Piotr Ponikowski, et al. “Acute heart failure in the young: Clinical characteristics and biomarker profiles.” Int J Cardiol 221 (October 15, 2016): 1067–72. https://doi.org/10.1016/j.ijcard.2016.06.339.
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  - Cotter, Gad, Beth A. Davison, Olga Milo, Robert C. Bourge, John G. F. Cleland, Guillaume Jondeau, Henry Krum, et al. “Predictors and Associations With Outcomes of Length of Hospital Stay in Patients With Acute Heart Failure: Results From VERITAS.” J Card Fail 22, no. 10 (October 2016): 815–22. https://doi.org/10.1016/j.cardfail.2015.12.017.
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  - O’Connor, Christopher M. “The International Olympic Games: Heart Teams and Heart Failure.” Jacc Heart Fail 4, no. 10 (October 2016): 826–27. https://doi.org/10.1016/j.jchf.2016.08.004.
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  - Greene, Stephen J., Adrian F. Hernandez, Jie-Lena Sun, Marco Metra, Javed Butler, Andrew P. Ambrosy, Justin A. Ezekowitz, et al. “Influence of Clinical Trial Site Enrollment on Patient Characteristics, Protocol Completion, and End Points: Insights From the ASCEND-HF Trial (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure).” Circ Heart Fail 9, no. 9 (September 2016). https://doi.org/10.1161/CIRCHEARTFAILURE.116.002986.
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  - Luo, Nancy, Joseph G. Rogers, Gwen C. Dodson, Chetan B. Patel, Anthony N. Galanos, Carmelo A. Milano, Christopher M. O’Connor, and Robert J. Mentz. “Usefulness of Palliative Care to Complement the Management of Patients on Left Ventricular Assist Devices.” Am J Cardiol 118, no. 5 (September 1, 2016): 733–38. https://doi.org/10.1016/j.amjcard.2016.06.010.
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  - O’Connor, Christopher M. “The Mentor's Mentor: The Life of Galen Wagner.” Jacc Heart Fail 4, no. 9 (September 2016): 759. https://doi.org/10.1016/j.jchf.2016.07.009.
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  - Davison, Beth A., Marco Metra, Stefanie Senger, Christopher Edwards, Olga Milo, Daniel M. Bloomfield, John G. Cleland, et al. “Patient journey after admission for acute heart failure: length of stay, 30-day readmission and 90-day mortality.” Eur J Heart Fail 18, no. 8 (August 2016): 1041–50. https://doi.org/10.1002/ejhf.540.
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  - Kelly, Jacob P., Allison Dunning, Phillip J. Schulte, Mona Fiuzat, Eric S. Leifer, Jerome L. Fleg, Lawton S. Cooper, et al. “Statins and Exercise Training Response in Heart Failure Patients: Insights From HF-ACTION.” Jacc Heart Fail 4, no. 8 (August 2016): 617–24. https://doi.org/10.1016/j.jchf.2016.05.006.
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  - Kelly, Jacob P., Lauren B. Cooper, Dianne Gallup, Kevin J. Anstrom, Horng H. Chen, Margaret M. Redfield, Christopher M. O’Connor, Robert J. Mentz, Adrian F. Hernanadez, and G Michael Felker. “Implications of Using Different Definitions on Outcomes in Worsening Heart Failure.” Circ Heart Fail 9, no. 8 (August 2016). https://doi.org/10.1161/CIRCHEARTFAILURE.116.003048.
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  - O’Connor, Christopher M. “Can Academic Cardiology Divisions Survive?” Jacc Heart Fail 4, no. 8 (August 2016): 687–88. https://doi.org/10.1016/j.jchf.2016.06.001.
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  - Paine, Nicola J., Alan L. Hinderliter, James A. Blumenthal, Kirkwood F. Adams, Carla A. Sueta, Patricia P. Chang, Christopher M. O’Connor, and Andrew Sherwood. “Reactive hyperemia is associated with adverse clinical outcomes in heart failure.” Am Heart J 178 (August 2016): 108–14. https://doi.org/10.1016/j.ahj.2016.05.008.
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  - Ter Maaten, Jozine M., Kevin Damman, Jennifer S. Hanberg, Michael M. Givertz, Marco Metra, Christopher M. O’Connor, John R. Teerlink, et al. “Hypochloremia, Diuretic Resistance, and Outcome in Patients With Acute Heart Failure.” Circ Heart Fail 9, no. 8 (August 2016). https://doi.org/10.1161/CIRCHEARTFAILURE.116.003109.
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  - Banks, Adam Z., Robert J. Mentz, Amanda Stebbins, Catherine R. Mikus, Phillip J. Schulte, Jerome L. Fleg, Lawton S. Cooper, et al. “Response to Exercise Training and Outcomes in Patients With Heart Failure and Diabetes Mellitus: Insights From the HF-ACTION Trial.” J Card Fail 22, no. 7 (July 2016): 485–91. https://doi.org/10.1016/j.cardfail.2015.12.007.
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  - Biegus, Jan, Hans L. Hillege, Douwe Postmus, Mattia A. E. Valente, Daniel M. Bloomfield, John G. F. Cleland, Gad Cotter, et al. “Abnormal liver function tests in acute heart failure: relationship with clinical characteristics and outcome in the PROTECT study.” Eur J Heart Fail 18, no. 7 (July 2016): 830–39. https://doi.org/10.1002/ejhf.532.
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  - Denardo, Scott J., David M. Vock, Carsten M. Schmalfuss, Gregory D. Young, James E. Tcheng, and Christopher M. O’Connor. “Baseline Hemodynamics and Response to Contrast Media During Diagnostic Cardiac Catheterization Predict Adverse Events in Heart Failure Patients.” Circ Heart Fail 9, no. 7 (July 2016). https://doi.org/10.1161/CIRCHEARTFAILURE.115.002529.
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  - O’Connor, Christopher M. “The Year in Heart Failure Review 2015 to 2016.” Jacc Heart Fail 4, no. 7 (July 2016): 603–4. https://doi.org/10.1016/j.jchf.2016.05.005.
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  - Reeves, Gordon R., David J. Whellan, Mahesh J. Patel, Christopher M. O’Connor, Pamela Duncan, Joel D. Eggebeen, Timothy M. Morgan, Leigh A. Hewston, Amy M. Pastva, and Dalane W. Kitzman. “Comparison of Frequency of Frailty and Severely Impaired Physical Function in Patients ≥60 Years Hospitalized With Acute Decompensated Heart Failure Versus Chronic Stable Heart Failure With Reduced and Preserved Left Ventricular Ejection Fraction.” Am J Cardiol 117, no. 12 (June 15, 2016): 1953–58. https://doi.org/10.1016/j.amjcard.2016.03.046.
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  - Emmens, Johanna E., Jozine M. Ter Maaten, Yuya Matsue, Marco Metra, Christopher M. O’Connor, Piotr Ponikowski, John R. Teerlink, et al. “Plasma kidney injury molecule-1 in heart failure: renal mechanisms and clinical outcome.” Eur J Heart Fail 18, no. 6 (June 2016): 641–49. https://doi.org/10.1002/ejhf.426.
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  - Metra, Marco, Robert J. Mentz, Adrian F. Hernandez, Gretchen M. Heizer, Paul W. Armstrong, Nadine Clausell, Ramon Corbalan, et al. “Geographic Differences in Patients in a Global Acute Heart Failure Clinical Trial (from the ASCEND-HF Trial).” Am J Cardiol 117, no. 11 (June 1, 2016): 1771–78. https://doi.org/10.1016/j.amjcard.2016.03.002.
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  - O’Connor, Christopher M. “Social Media: Can It Reduce Heart Failure Events?” Jacc Heart Fail 4, no. 6 (June 2016): 514–15. https://doi.org/10.1016/j.jchf.2016.04.006.
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  - Ter Maaten, Jozine M., Mattia A. E. Valente, Kevin Damman, John G. Cleland, Michael M. Givertz, Marco Metra, Christopher M. O’Connor, et al. “Combining Diuretic Response and Hemoconcentration to Predict Rehospitalization After Admission for Acute Heart Failure.” Circ Heart Fail 9, no. 6 (June 2016). https://doi.org/10.1161/CIRCHEARTFAILURE.115.002845.
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  - Whellan, David J., Amanda Stebbins, Adrian F. Hernandez, Justin A. Ezekowitz, John J. V. McMurray, Paul J. Mather, Vic Hasselblad, and Christopher M. O’Connor. “Dichotomous Relationship Between Age and 30-Day Death or Rehospitalization in Heart Failure Patients Admitted With Acute Decompensated Heart Failure: Results From the ASCEND-HF Trial.” J Card Fail 22, no. 6 (June 2016): 409–16. https://doi.org/10.1016/j.cardfail.2016.02.011.
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  - Wong, Yee Weng, Robert J. Mentz, G Michael Felker, Justin Ezekowitz, Karen Pieper, Gretchen Heizer, Vic Hasselblad, et al. “Nesiritide in patients hospitalized for acute heart failure: does timing matter? Implication for future acute heart failure trials.” Eur J Heart Fail 18, no. 6 (June 2016): 684–92. https://doi.org/10.1002/ejhf.487.
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  - Navarese, Eliano P., Michalina Kolodziejczak, Dean J. Kereiakes, Udaya S. Tantry, Christopher O’Connor, and Paul A. Gurbel. “Proprotein Convertase Subtilisin/Kexin Type 9 Monoclonal Antibodies for Acute Coronary Syndrome: A Narrative Review.” Ann Intern Med 164, no. 9 (May 3, 2016): 600–607. https://doi.org/10.7326/M15-2994.
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  - O’Connor, Christopher M., Mona Fiuzat, and JoAnn Lindenfeld. “Are We Really in Love With Old Therapies?” Jacc Heart Fail, April 12, 2016. https://doi.org/10.1016/j.jchf.2016.02.011.
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  - Garber, Adam M., Robert J. Mentz, Hussein R. Al-Khalidi, Linda K. Shaw, Mona Fiuzat, Christopher M. O’Connor, and Eric J. Velazquez. “Clinical predictors and outcomes of patients with left ventricular thrombus following ST-segment elevation myocardial infarction.” J Thromb Thrombolysis 41, no. 3 (April 2016): 365–73. https://doi.org/10.1007/s11239-015-1252-0.
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  - Ovchinnikova, Ekaterina S., Daniela Schmitter, Eline L. Vegter, Jozine M. Ter Maaten, Mattia A. E. Valente, Licette C. Y. Liu, Pim van der Harst, et al. “Signature of circulating microRNAs in patients with acute heart failure.” Eur J Heart Fail 18, no. 4 (April 2016): 414–23. https://doi.org/10.1002/ejhf.332.
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  - O’Connor, Christopher M. “Why Negative Trials Are Positive for Heart Failure Patients.” Jacc Heart Fail 4, no. 4 (April 2016): 329–30. https://doi.org/10.1016/j.jchf.2016.02.010.
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  - Rosendorff, Clive, and Clive Writing Committee. “Treatment of Hypertension in Patients with Coronary Artery Disease. A Case-Based Summary of the 2015 AHA/ACC/ASH Scientific Statement.” Am J Med 129, no. 4 (April 2016): 372–78. https://doi.org/10.1016/j.amjmed.2015.10.045.
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  - Samsky, Marc D., Allison Dunning, Adam D. DeVore, Phillip J. Schulte, Randall C. Starling, WH Wilson Tang, Paul W. Armstrong, et al. “Liver function tests in patients with acute heart failure and associated outcomes: insights from ASCEND-HF.” Eur J Heart Fail 18, no. 4 (April 2016): 424–32. https://doi.org/10.1002/ejhf.440.
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  - Ezekowitz, Justin A., Mohua Podder, Adrian F. Hernandez, Paul W. Armstrong, Randall C. Starling, Christopher M. O’Connor, and Robert M. Califf. “Arrival by ambulance in acute heart failure: insights into the mode of presentation from Acute Studies of Nesiritide in Decompensated Heart Failure (ASCEND-HF).” Bmj Open 6, no. 3 (March 17, 2016): e010201. https://doi.org/10.1136/bmjopen-2015-010201.
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  - Ambrosy, Andrew P., Adrian F. Hernandez, Paul W. Armstrong, Javed Butler, Allison Dunning, Justin A. Ezekowitz, G Michael Felker, et al. “The clinical course of health status and association with outcomes in patients hospitalized for heart failure: insights from ASCEND-HF.” Eur J Heart Fail 18, no. 3 (March 2016): 306–13. https://doi.org/10.1002/ejhf.420.
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  - Cooper, Lauren B., Robert J. Mentz, Susanna R. Stevens, G Michael Felker, Carlo Lombardi, Marco Metra, Lynne W. Stevenson, et al. “Hemodynamic Predictors of Heart Failure Morbidity and Mortality: Fluid or Flow?” J Card Fail 22, no. 3 (March 2016): 182–89. https://doi.org/10.1016/j.cardfail.2015.11.012.
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  - Demissei, Biniyam G., Mattia A. E. Valente, John G. Cleland, Christopher M. O’Connor, Marco Metra, Piotr Ponikowski, John R. Teerlink, et al. “Optimizing clinical use of biomarkers in high-risk acute heart failure patients.” Eur J Heart Fail 18, no. 3 (March 2016): 269–80. https://doi.org/10.1002/ejhf.443.
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  - Fiuzat, Mona, Olaf Oldenberg, David J. Whellan, Holger Woehrle, Naresh M. Punjabi, Kevin J. Anstrom, Amy B. Blase, Adam V. Benjafield, JoAnn Lindenfeld, and Christopher M. O’Connor. “Lessons learned from a clinical trial: Design, rationale, and insights from The Cardiovascular Improvements with Minute Ventilation-targeted Adaptive Sero-Ventilation (ASV) Therapy in Heart Failure (CAT-HF) Study.” Contemp Clin Trials 47 (March 2016): 158–64. https://doi.org/10.1016/j.cct.2016.01.001.
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  - O’Connor, Christopher M. “I Lost a Friend From HFpEF: William Anlyan, MD, Chancellor Emeritus and Duke University Trustee.” Jacc Heart Fail 4, no. 3 (March 2016): 230–31. https://doi.org/10.1016/j.jchf.2016.01.007.
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  - Perez, Antonio L., Justin L. Grodin, Yuping Wu, Adrian F. Hernandez, Javed Butler, Marco Metra, G Michael Felker, et al. “Increased mortality with elevated plasma endothelin-1 in acute heart failure: an ASCEND-HF biomarker substudy.” Eur J Heart Fail 18, no. 3 (March 2016): 290–97. https://doi.org/10.1002/ejhf.456.
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  - Keteyian, Steven J., Mahesh Patel, William E. Kraus, Clinton A. Brawner, Timothy R. McConnell, Ileana L. Piña, Eric S. Leifer, et al. “Variables Measured During Cardiopulmonary Exercise Testing as Predictors of Mortality in Chronic Systolic Heart Failure.” J Am Coll Cardiol 67, no. 7 (February 23, 2016): 780–89. https://doi.org/10.1016/j.jacc.2015.11.050.
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  - Demissei, Biniyam G., John G. Cleland, Christopher M. O’Connor, Marco Metra, Piotr Ponikowski, John R. Teerlink, Beth Davison, et al. “Procalcitonin-based indication of bacterial infection identifies high risk acute heart failure patients.” Int J Cardiol 204 (February 1, 2016): 164–71. https://doi.org/10.1016/j.ijcard.2015.11.141.
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  - Fiuzat, Mona, Daniel Wojdyla, Ileana Pina, Kirkwood Adams, David Whellan, and Christopher M. O’Connor. “Heart Rate or Beta-Blocker Dose? Association With Outcomes in Ambulatory Heart Failure Patients With Systolic Dysfunction: Results From the HF-ACTION Trial.” Jacc Heart Fail 4, no. 2 (February 2016): 109–15. https://doi.org/10.1016/j.jchf.2015.09.002.
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  - Maaten, Jozine M. ter, Mattia A. E. Valente, Marco Metra, Noemi Bruno, Christopher M. O’Connor, Piotr Ponikowski, John R. Teerlink, et al. “A combined clinical and biomarker approach to predict diuretic response in acute heart failure.” Clin Res Cardiol 105, no. 2 (February 2016): 145–53. https://doi.org/10.1007/s00392-015-0896-2.
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  - Mark, Daniel B., and Christopher M. O’Connor. “When Business and Science Clash, How Can We Avoid Harming Patients?: The Case of AVOID-HF.” Jacc Heart Fail 4, no. 2 (February 2016): 106–8. https://doi.org/10.1016/j.jchf.2015.09.001.
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  - Mentz, Robert J., Vic Hasselblad, Adam D. DeVore, Marco Metra, Adriaan A. Voors, Paul W. Armstrong, Justin A. Ezekowitz, et al. “Torsemide Versus Furosemide in Patients With Acute Heart Failure (from the ASCEND-HF Trial).” Am J Cardiol 117, no. 3 (February 1, 2016): 404–11. https://doi.org/10.1016/j.amjcard.2015.10.059.
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  - O’Connor, Christopher M. “Death of the Heart Failure Clinical Investigator: Molecules and Receptors Win Nobel Prizes, Clinical Investigation Improves Survival.” Jacc Heart Fail 4, no. 2 (February 2016): 162–63. https://doi.org/10.1016/j.jchf.2015.12.001.
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  - Ahmad, Tariq, Jacob P. Kelly, Robert W. McGarrah, Anne S. Hellkamp, Mona Fiuzat, Jeffrey M. Testani, Teresa S. Wang, et al. “Prognostic Implications of Long-Chain Acylcarnitines in Heart Failure and Reversibility With Mechanical Circulatory Support.” J Am Coll Cardiol 67, no. 3 (January 26, 2016): 291–99. https://doi.org/10.1016/j.jacc.2015.10.079.
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  - Bruno, Noemi, Jozine M. ter Maaten, Ekaterina S. Ovchinnikova, Eline L. Vegter, Mattia A. E. Valente, Peter van der Meer, Rudolf A. de Boer, et al. “MicroRNAs relate to early worsening of renal function in patients with acute heart failure.” Int J Cardiol 203 (January 15, 2016): 564–69. https://doi.org/10.1016/j.ijcard.2015.10.217.
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  - Ahmad, Tariq, Nihar Desai, Francis Wilson, Phillip Schulte, Allison Dunning, Daniel Jacoby, Larry Allen, et al. “Clinical Implications of Cluster Analysis-Based Classification of Acute Decompensated Heart Failure and Correlation with Bedside Hemodynamic Profiles.” Plos One 11, no. 2 (2016): e0145881. https://doi.org/10.1371/journal.pone.0145881.
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  - Mentz, Robert J., and Christopher M. O’Connor. “Pathophysiology and clinical evaluation of acute heart failure.” Nat Rev Cardiol 13, no. 1 (January 2016): 28–35. https://doi.org/10.1038/nrcardio.2015.134.
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  - O’Connor, Christopher M. “Why Dr. Robert Califf's Nomination for Commissioner of the Food and Drug Administration Is Good for Heart Failure Patients.” Jacc Heart Fail 4, no. 1 (January 2016): 90–91. https://doi.org/10.1016/j.jchf.2015.11.004.
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  - Tang, WH Wilson, Yuping Wu, Justin L. Grodin, Amy P. Hsu, Adrian F. Hernandez, Javed Butler, Marco Metra, et al. “Prognostic Value of Baseline and Changes in Circulating Soluble ST2 Levels and the Effects of Nesiritide in Acute Decompensated Heart Failure.” Jacc Heart Fail 4, no. 1 (January 2016): 68–77. https://doi.org/10.1016/j.jchf.2015.07.015.
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  - Brunner-La Rocca, Hans-Peter, Luc Eurlings, A Mark Richards, James L. Januzzi, Matthias E. Pfisterer, Ulf Dahlström, Yigal M. Pinto, et al. “Which heart failure patients profit from natriuretic peptide guided therapy? A meta-analysis from individual patient data of randomized trials.” Eur J Heart Fail 17, no. 12 (December 2015): 1252–61. https://doi.org/10.1002/ejhf.401.
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  - O’Connor, Christopher M. “Heart Failure "End Result Cards": Solid B.” Jacc Heart Fail 3, no. 12 (December 2015): 1001–2. https://doi.org/10.1016/j.jchf.2015.10.004.
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  - Cooper, Lauren B., Robert J. Mentz, Jie-Lena Sun, Phillip J. Schulte, Jerome L. Fleg, Lawton S. Cooper, Ileana L. Piña, et al. “Psychosocial Factors, Exercise Adherence, and Outcomes in Heart Failure Patients: Insights From Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION).” Circ Heart Fail 8, no. 6 (November 2015): 1044–51. https://doi.org/10.1161/CIRCHEARTFAILURE.115.002327.
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  - O’Connor, Christopher M. “Bundle Up for Value-Based Heart Failure Care.” Jacc Heart Fail 3, no. 11 (November 2015): 931–32. https://doi.org/10.1016/j.jchf.2015.09.003.
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  - Samad, Zainab, Linda K. Shaw, Matthew Phelan, Mads Ersboll, Niels Risum, Hussein R. Al-Khalidi, Donald D. Glower, et al. “Management and outcomes in patients with moderate or severe functional mitral regurgitation and severe left ventricular dysfunction.” Eur Heart J 36, no. 40 (October 21, 2015): 2733–41. https://doi.org/10.1093/eurheartj/ehv343.
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  - Grodin, Justin L., Antonio L. Perez, Yuping Wu, Adrian F. Hernandez, Javed Butler, Marco Metra, G Michael Felker, et al. “Circulating Kidney Injury Molecule-1 Levels in Acute Heart Failure: Insights From the ASCEND-HF Trial (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure).” Jacc Heart Fail 3, no. 10 (October 2015): 777–85. https://doi.org/10.1016/j.jchf.2015.06.006.
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  - Felker, G Michael, Robert J. Mentz, Kirkwood F. Adams, Robert T. Cole, Gregory F. Egnaczyk, Chetan B. Patel, Mona Fiuzat, et al. “Tolvaptan in Patients Hospitalized With Acute Heart Failure: Rationale and Design of the TACTICS and the SECRET of CHF Trials.” Circ Heart Fail 8, no. 5 (September 2015): 997–1005. https://doi.org/10.1161/CIRCHEARTFAILURE.115.002259.
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  - Mentz, Robert J., Eric J. Velazquez, Marco Metra, Colleen McKendry, Karen Chiswell, Mona Fiuzat, Michael M. Givertz, Adriaan A. Voors, John R. Teerlink, and Christopher M. O’Connor. “Comparative effectiveness of torsemide versus furosemide in heart failure patients: insights from the PROTECT trial.” Future Cardiol 11, no. 5 (September 2015): 585–95. https://doi.org/10.2217/fca.15.56.
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  - O’Connor, Christopher M. “What Is a Life Worth?: A Tribute to Dr. William Little, a Pioneer in the Understanding of Heart Failure With Preserved Ejection Fraction.” Jacc Heart Fail 3, no. 9 (September 2015): 734–35. https://doi.org/10.1016/j.jchf.2015.07.002.
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  - Xiong, Glen L., Kevin Prybol, Stephen H. Boyle, Russell Hall, Robert D. Streilein, David C. Steffens, Ranga Krishnan, et al. “Inflammation Markers and Major Depressive Disorder in Patients With Chronic Heart Failure: Results From the Sertraline Against Depression and Heart Disease in Chronic Heart Failure Study.” Psychosom Med 77, no. 7 (September 2015): 808–15. https://doi.org/10.1097/PSY.0000000000000216.
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  - Abualnaja, Seraj, Mohua Podder, Adrian F. Hernandez, John J. V. McMurray, Randall C. Starling, Christopher M. O’Connor, Robert M. Califf, Paul W. Armstrong, and Justin A. Ezekowitz. “Acute Heart Failure and Atrial Fibrillation: Insights From the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure (ASCEND-HF) Trial.” J Am Heart Assoc 4, no. 8 (August 24, 2015): e002092. https://doi.org/10.1161/JAHA.115.002092.
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  - O’Connor, Christopher M., and Tariq Ahmad. “The Role of Sodium and Chloride in Heart Failure: Does It Take Two to Tango?” J Am Coll Cardiol 66, no. 6 (August 11, 2015): 667–69. https://doi.org/10.1016/j.jacc.2015.05.070.
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  - Dardas, Todd, Yanhong Li, Shelby D. Reed, Christopher M. O’Connor, David J. Whellan, Stephen J. Ellis, Kevin A. Schulman, William E. Kraus, Daniel E. Forman, and Wayne C. Levy. “Incremental and independent value of cardiopulmonary exercise test measures and the Seattle Heart Failure Model for prediction of risk in patients with heart failure.” J Heart Lung Transplant 34, no. 8 (August 2015): 1017–23. https://doi.org/10.1016/j.healun.2015.03.017.
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  - Farzaneh-Far, Afshin, Linda K. Shaw, Allison Dunning, Jorge D. Oldan, Christopher M. O’Connor, and Salvador Borges-Neto. “Comparison of the prognostic value of regadenoson and adenosine myocardial perfusion imaging.” J Nucl Cardiol 22, no. 4 (August 2015): 600–607. https://doi.org/10.1007/s12350-015-0155-y.
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  - Hess, Paul L., Linda K. Shaw, Sreekanth Vemulapalli, Robert Pagnanelli, Christopher M. O’Connor, and Salvador Borges-Neto. “An alternative method to examine the predictive value of mechanical dyssynchrony.” J Nucl Cardiol 22, no. 4 (August 2015): 686–89. https://doi.org/10.1007/s12350-015-0145-0.
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  - Kelly, Jacob P., Robert J. Mentz, Vic Hasselblad, Justin A. Ezekowitz, Paul W. Armstrong, Faiez Zannad, G Michael Felker, Robert M. Califf, Christopher M. O’Connor, and Adrian F. Hernandez. “Worsening heart failure during hospitalization for acute heart failure: Insights from the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure (ASCEND-HF).” Am Heart J 170, no. 2 (August 2015): 298–305. https://doi.org/10.1016/j.ahj.2015.04.007.
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  - Khazanie, Prateeti, Gretchen M. Heizer, Vic Hasselblad, Paul W. Armstrong, Robert M. Califf, Justin Ezekowitz, Kenneth Dickstein, et al. “Predictors of clinical outcomes in acute decompensated heart failure: Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure outcome models.” Am Heart J 170, no. 2 (August 2015): 290–97. https://doi.org/10.1016/j.ahj.2015.04.006.
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  - Maaten, Jozine M. ter, Allison M. Dunning, Mattia A. E. Valente, Kevin Damman, Justin A. Ezekowitz, Robert M. Califf, Randall C. Starling, et al. “Diuretic response in acute heart failure-an analysis from ASCEND-HF.” Am Heart J 170, no. 2 (August 2015): 313–21. https://doi.org/10.1016/j.ahj.2015.05.003.
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  - O’Connor, Christopher M. “The Globalization of Heart Failure Research.” Jacc Heart Fail 3, no. 8 (August 2015): 657–58. https://doi.org/10.1016/j.jchf.2015.06.001.
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  - Hernandez, Adrian F., and Christopher M. O’Connor. “Sparing a little may save a lot: lessons from the Studies of Left Ventricular Dysfunction (SOLVD).” J Am Coll Cardiol 42, no. 4 (August 20, 2003): 709–11. https://doi.org/10.1016/s0735-1097(03)00766-6.
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  - Shah, Bimal R., Eric Velazquez, Linda K. Shaw, Brad Bart, Christopher O’Connor, and Galen S. Wagner. “Revascularization improves survival in ischemic cardiomyopathy regardless of electrocardiographic criteria for prior small-to-medium myocardial infarcts..” Am Heart J 143, no. 1 (January 2002): 111–17. https://doi.org/10.1067/mhj.2002.119996.
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  - Serebruany, V. L., C. J. Davis, A. F. Meister, D. Atar, D. J. Whellan, and C. M. O’Connor. “Biomarkers and exercise training: A possible missing link between physical activity and mortality benefit in patients with heart failure.” Heartdrug 1, no. 2 (December 1, 2001): 110–24. https://doi.org/10.1159/000048946.
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  - Carney, R. M., J. A. Blumenthal, P. K. Stein, L. Watkins, D. Catellier, L. F. Berkman, S. M. Czajkowski, C. O’Connor, P. H. Stone, and K. E. Freedland. “Depression, heart rate variability, and acute myocardial infarction.” Circulation 104, no. 17 (October 23, 2001): 2024–28. https://doi.org/10.1161/hc4201.097834.
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  - ENRICHD Investigators, S. A. “Enhancing Recovery in Coronary Heart Disease (ENRICHD) study intervention: rationale and design.” Psychosom Med 63, no. 5 (September 2001): 747–55.
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  - O’Connor, C. M., W. A. Gattis, A. S. Hellkamp, A. Langer, R. L. Larsen, R. A. Harrington, S. D. Berkowitz, et al. “Comparison of two aspirin doses on ischemic stroke in post-myocardial infarction patients in the warfarin (Coumadin) Aspirin Reinfarction Study (CARS).” Am J Cardiol 88, no. 5 (September 1, 2001): 541–46. https://doi.org/10.1016/s0002-9149(01)01735-0.
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  - Alexander, K. P., L. K. Newby, A. S. Hellkamp, R. A. Harrington, E. D. Peterson, S. Kopecky, A. Langer, et al. “Initiation of hormone replacement therapy after acute myocardial infarction is associated with more cardiac events during follow-up.” J Am Coll Cardiol 38, no. 1 (July 2001): 1–7. https://doi.org/10.1016/s0735-1097(01)01329-8.
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  - Whellan, D. J., L. K. Shaw, B. A. Bart, W. E. Kraus, R. M. Califf, and C. M. O’Connor. “Cardiac rehabilitation and survival in patients with left ventricular systolic dysfunction.” Am Heart J 142, no. 1 (July 2001): 160–66. https://doi.org/10.1067/mhj.2001.115785.
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  - Serebruany, V. L., C. M. O’Connor, and P. A. Gurbel. “Effect of selective serotonin reuptake inhibitors on platelets in patients with coronary artery disease.” Am J Cardiol 87, no. 12 (June 15, 2001): 1398–1400. https://doi.org/10.1016/s0002-9149(01)01562-4.
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  - Rosenberg, E. L., P. Ekman, W. Jiang, M. Babyak, R. E. Coleman, M. Hanson, C. O’Connor, R. Waugh, and J. A. Blumenthal. “Linkages between facial expressions of anger and transient myocardial ischemia in men with coronary artery disease.” Emotion 1, no. 2 (June 2001): 107–15. https://doi.org/10.1037/1528-3542.1.2.107.
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  - Shah, M. R., S. S. Stinnett, S. E. McNulty, M. Gheorghiade, F. Zannad, B. Uretsky, K. F. Adams, R. M. Califf, and C. M. O’connor. “Hemodynamics as surrogate end points for survival in advanced heart failure: an analysis from FIRST.” Am Heart J 141, no. 6 (June 2001): 908–14. https://doi.org/10.1067/mhj.2001.115299.
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  - Shah, M. R., V. Hasselblad, S. S. Stinnett, M. Gheorghiade, K. Swedberg, R. M. Califf, and C. M. O’Connor. “Hemodynamic profiles of advanced heart failure: association with clinical characteristics and long-term outcomes.” J Card Fail 7, no. 2 (June 2001): 105–13. https://doi.org/10.1054/jcaf.2001.24131.
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  - Serebruany, V. L., P. A. Gurbel, and C. M. O’Connor. “Platelet inhibition by sertraline and N-desmethylsertraline: a possible missing link between depression, coronary events, and mortality benefits of selective serotonin reuptake inhibitors.” Pharmacol Res 43, no. 5 (May 2001): 453–62. https://doi.org/10.1006/phrs.2001.0817.
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  - Shah, M. R., C. M. O’Connor, G. Sopko, V. Hasselblad, R. M. Califf, and L. W. Stevenson. “Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness (ESCAPE): design and rationale.” Am Heart J 141, no. 4 (April 2001): 528–35. https://doi.org/10.1067/mhj.2001.113995.
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  - Gurbel, P. A., C. M. O’Connor, M. R. Dalesandro, and V. L. Serebruany. “Relation of soluble and platelet P-selectin to early outcome in patients with acute myocardial infarction after thrombolytic therapy.” Am J Cardiol 87, no. 6 (March 15, 2001): 774-A7. https://doi.org/10.1016/s0002-9149(00)01502-2.
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  - Serebruany, V. L., A. B. Alford, A. F. Meister, S. Y. Fuzaylov, W. A. Gattis, P. A. Gurbel, and C. M. O’Connor. “Clinical utility of the platelet function analyzer (PFA-100) for the assessment of the platelet status in patients with congestive heart failure (EPCOT trial).” Thromb Res 101, no. 6 (March 15, 2001): 427–33. https://doi.org/10.1016/s0049-3848(00)00431-x.
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  - Gattis, W. A., and C. M. O’Connor. “Effect of amlodipine on mode of death in advanced heart failure.” Cardiology Review 18, no. 2 (March 12, 2001): 13–19.
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  - Gattis, W. A., A. Galanos, and C. M. O’Connor. “Angiotensin-converting enzyme inhibitor dosing in heart failure: what is optimal?” Am Heart J 141, no. 3 (March 2001): 331–33. https://doi.org/10.1067/mhj.2001.113228.
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  - Shah, M. R., and C. M. O’connor. “The congestion score: a simple tool for a complicated disease?” Am Heart J 140, no. 6 (December 2000): 824–26. https://doi.org/10.1067/mhj.2000.110932.
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  - O’Connor, C. M., W. A. Gattis, L. Shaw, M. S. Cuffe, and R. M. Califf. “Clinical characteristics and long-term outcomes of patients with heart failure and preserved systolic function.” Am J Cardiol 86, no. 8 (October 15, 2000): 863–67. https://doi.org/10.1016/s0002-9149(00)01107-3.
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  - Nemeroff, C. B., and C. M. O’connor. “Introduction.” Am Heart J 140, no. 4 Suppl (October 2000): 55–56. https://doi.org/10.1067/mhj.2000.109976.
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  - O’connor, C. M., P. A. Gurbel, and V. L. Serebruany. “Depression and ischemic heart disease.” Am Heart J 140, no. 4 Suppl (October 2000): 63–69. https://doi.org/10.1067/mhj.2000.109979.
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  - Gattis, W., and C. M. O’Connor. “Calcium antagonist use in heart failure: A re-evalutaion of treatment options.” Drugs 59, no. SPEC. ISS. 2 (September 14, 2000): 17–24.
  - Varia, I., E. Logue, C. O’connor, K. Newby, H. R. Wagner, C. Davenport, K. Rathey, and K. R. Krishnan. “Randomized trial of sertraline in patients with unexplained chest pain of noncardiac origin.” Am Heart J 140, no. 3 (September 2000): 367–72. https://doi.org/10.1067/mhj.2000.108514.
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  - Carson, P. A., C. M. O’Connor, A. B. Miller, S. Anderson, R. Belkin, G. W. Neuberg, J. H. Wertheimer, D. Frid, A. Cropp, and M. Packer. “Circadian rhythm and sudden death in heart failure: results from Prospective Randomized Amlodipine Survival Trial.” J Am Coll Cardiol 36, no. 2 (August 2000): 541–46. https://doi.org/10.1016/s0735-1097(00)00728-2.
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  - Davis, C. J., P. A. Gurbel, W. A. Gattis, S. Y. Fuzaylov, G. V. Nair, C. M. O’Connor, and V. L. Serebruany. “Hemostatic abnormalities in patients with congestive heart failure: diagnostic significance and clinical challenge.” Int J Cardiol 75, no. 1 (August 2000): 15–21. https://doi.org/10.1016/s0167-5273(00)00300-4.
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  - Kong, D. F., M. A. Blazing, and C. M. O’Connor. “Advances in the approach to acute coronary syndromes.” Hosp Pract (1995) 35, no. 4 (April 15, 2000): 61–64. https://doi.org/10.3810/hp.2000.04.192.
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  - O’Connor, C. M., W. A. Gattis, and T. J. Ryan. “The role of clinical nonfatal end points in cardiovascular phase II/III clinical trials.” Am Heart J 139, no. 4 (April 2000): S143–54. https://doi.org/10.1016/s0002-8703(00)90062-0.
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  - Serebruany, V. L., D. R. Lowry, S. Y. Fuzailov, D. J. Levine, C. M. O’Connor, and P. A. Gurbel. “Moderate alcohol consumption is associated with decreased platelet activity in patients presenting with acute myocardial infarction.” J Thromb Thrombolysis 9, no. 3 (April 2000): 229–34. https://doi.org/10.1023/a:1018762510842.
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  - Califf, R. M., and C. M. O’Connor. “Beta-blocker therapy for heart failure: the evidence is in, now the work begins.” Jama 283, no. 10 (March 8, 2000): 1335–37. https://doi.org/10.1001/jama.283.10.1335.
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  - Shah, A., G. S. Wagner, C. B. Granger, C. M. O’Connor, C. L. Green, K. M. Trollinger, R. M. Califf, and M. W. Krucoff. “Prognostic implications of TIMI flow grade in the infarct related artery compared with continuous 12-lead ST-segment resolution analysis. Reexamining the "gold standard" for myocardial reperfusion assessment.” J Am Coll Cardiol 35, no. 3 (March 1, 2000): 666–72. https://doi.org/10.1016/s0735-1097(99)00601-4.
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  - Gurbel, P. A., D. J. Kereiakes, M. R. Dalesandro, R. D. Bahr, C. M. O’Connor, and V. L. Serebruany. “Role of soluble and platelet-bound P-selectin in discriminating cardiac from noncardiac chest pain at presentation in the emergency department.” Am Heart J 139, no. 2 Pt 1 (February 2000): 320–28. https://doi.org/10.1067/mhj.2000.101109.
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  - Bosworth, H. B., D. C. Steffens, M. N. Kuchibhatla, W. J. Jiang, R. M. Arias, C. M. O’Connor, and K. R. R. Krishnan. “The relationship of social support, social networks and negative events with depression in patients with coronary artery disease.” Aging and Mental Health 4, no. 3 (January 1, 2000): 253–58. https://doi.org/10.1080/713649927.
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  - Cuffe, M. S., R. M. Califf, K. F. Adams, R. C. Bourge, W. Colucci, B. Massie, C. M. O’Connor, et al. “Rationale and design of the OPTIME CHF trial: outcomes of a prospective trial of intravenous milrinone for exacerbations of chronic heart failure.” Am Heart J 139, no. 1 Pt 1 (January 2000): 15–22. https://doi.org/10.1016/s0002-8703(00)90303-x.
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  - Gattis, W., and C. M. O’Connor. “[Calcium antagonists in the treatment of heart failure. Re-evaluation of therapeutic strategies].” Drugs 59 Spec No 2 (2000): 17–24.
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  - Gurbel, P. A., D. J. Kereiakes, M. R. Dalesandro, R. D. Bahr, C. M. O’Connor, and V. L. Serebruany. “Role of soluble and platelet-bound P-selectin in discriminating cardiac from noncardiac chest pain at presentation in the emergency department.” American Heart Journal 139, no. 2 I (2000): 320–28.
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  - Velazquez, E. J., and C. M. O’Connor. “Heart failure after myocardial infarction: A good heart is hard to find.” Am Heart J 138, no. 6 Pt 1 (December 1999): 1009–11. https://doi.org/10.1016/s0002-8703(99)70061-x.
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  - Orloff, D. G., M. A. Blazing, and C. M. O’Connor. “Atherosclerotic disease in non-insulin-dependent diabetes mellitus: role of abnormal lipids and the place for lipid-altering therapies.” Am Heart J 138, no. 5 Pt 1 (November 1999): S406–12. https://doi.org/10.1016/s0002-8703(99)70043-8.
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  - Del Carlo, C. H., and C. M. O’Connor. “Cardiac troponins in congestive heart failure.” Am Heart J 138, no. 4 Pt 1 (October 1999): 646–53. https://doi.org/10.1016/s0002-8703(99)70178-x.
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  - Del Carlo, C. H., and C. M. O’Connor. “Cardiac troponins in congestive heart failure.” American Heart Journal 138, no. 4 Pt 1 (October 1999): 646–53. https://doi.org/10.1016/s0002-8703(99)70178-x.
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  - Langer, A., M. Fisher, R. M. Califf, S. Goodman, C. M. O’Connor, R. A. Harrington, and V. Fuster. “Higher rates of coronary angiography and revascularization following myocardial infarction may be associated with greater survival in the United States than in Canada. The CARS Investigators (Coumadin/Aspirin Reinfarction Study).” Can J Cardiol 15, no. 10 (October 1999): 1095–1102.
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  - Langer, A., M. Fisher, R. M. Califf, S. Goodman, C. M. O’Connor, R. A. Harrington, and V. Fuster. “Higher rates of coronary angiography and revascularization following myocardial infarction may be associated with greater survival in the United States than in Canada.” Canadian Journal of Cardiology 15, no. 10 (October 1, 1999): 1095–1102.
  - Gattis, W. A., V. Hasselblad, D. J. Whellan, and C. M. O’Connor. “Reduction in heart failure events by the addition of a clinical pharmacist to the heart failure management team: results of the Pharmacist in Heart Failure Assessment Recommendation and Monitoring (PHARM) Study.” Arch Intern Med 159, no. 16 (September 13, 1999): 1939–45. https://doi.org/10.1001/archinte.159.16.1939.
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  - Gurbel, P. A., C. M. O’Connor, C. C. Cummings, and V. L. Serebruany. “Clopidogrel: the future choice for preventing platelet activation during coronary stenting?” Pharmacol Res 40, no. 2 (August 1999): 107–11. https://doi.org/10.1006/phrs.1999.0478.
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  - Nair, G. V., P. A. Gurbel, C. M. O’Connor, W. A. Gattis, S. R. Murugesan, and V. L. Serebruany. “Depression, coronary events, platelet inhibition, and serotonin reuptake inhibitors.” Am J Cardiol 84, no. 3 (August 1, 1999): 321-A8. https://doi.org/10.1016/s0002-9149(99)00284-2.
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  - Serebruany, V. L., S. R. Murugesan, A. Pothula, D. Atar, D. R. Lowry, C. M. O’Connor, and P. A. Gurbel. “Increased soluble platelet/endothelial cellular adhesion molecule-1 and osteonectin levels in patients with severe congestive heart failure. Independence of disease etiology, and antecedent aspirin therapy.” Eur J Heart Fail 1, no. 3 (August 1999): 243–49. https://doi.org/10.1016/s1388-9842(99)00029-x.
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  - Blazing, M. A., and C. M. O’Connor. “Evidence supporting secondary prevention strategies.” Curr Opin Cardiol 14, no. 4 (July 1999): 303–9. https://doi.org/10.1097/00001573-199907000-00005.
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  - O’Connor, C. M., P. W. Radensky, A. N. Unger, and B. C. Martin. “Hospital use and costs among patients with nonischemic cardiomyopathy in the first prospective randomized amlodipine survival evaluation study.” Clin Ther 21, no. 7 (July 1999): 1254–65. https://doi.org/10.1016/S0149-2918(00)80027-2.
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  - O’Connor, C. M., W. A. Gattis, and K. Swedberg. “Current and novel pharmacologic approaches in advanced heart failure.” Heart Lung 28, no. 4 (July 1999): 227–42. https://doi.org/10.1016/s0147-9563(99)70069-5.
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  - Shapiro, P. A., F. Lespérance, N. Frasure-Smith, C. M. O’Connor, B. Baker, J. W. Jiang, P. Dorian, W. Harrison, and A. H. Glassman. “An open-label preliminary trial of sertraline for treatment of major depression after acute myocardial infarction (the SADHAT Trial). Sertraline Anti-Depressant Heart Attack Trial.” Am Heart J 137, no. 6 (June 1999): 1100–1106. https://doi.org/10.1016/s0002-8703(99)70369-8.
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  - Kong, D. F., M. A. Blazing, and C. M. O’Connor. “The health care burden of unstable angina.” Cardiol Clin 17, no. 2 (May 1999): 247–61. https://doi.org/10.1016/s0733-8651(05)70072-2.
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  - O’Connor, C. M., P. A. Gurbel, and V. L. Serebruany. “Usefulness of soluble and surface-bound P-selectin in detecting heightened platelet activity in patients with congestive heart failure.” Am J Cardiol 83, no. 9 (May 1, 1999): 1345–49. https://doi.org/10.1016/s0002-9149(99)00098-3.
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  - Adams, K. F., C. A. Sueta, M. Gheorghiade, C. M. O’Connor, T. A. Schwartz, G. G. Koch, B. Uretsky, et al. “Gender differences in survival in advanced heart failure. Insights from the FIRST study.” Circulation 99, no. 14 (April 13, 1999): 1816–21. https://doi.org/10.1161/01.cir.99.14.1816.
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  - Whellan, D. J., W. A. Gattis, L. Gaulden, B. Granger, and C. M. O’Connor. “Disease management of congestive heart failure.” Am J Manag Care 5, no. 4 (April 1999): 499–507.
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  - O’Connor, C. M., W. A. Gattis, F. Zannad, S. E. McNulty, M. Gheorghiade, K. F. Adams, R. M. Califf, W. J. McKenna, J. Soler-Soler, and K. Swedberg. “Beta-blocker therapy in advanced heart failure: clinical characteristics and long-term outcomes.” Eur J Heart Fail 1, no. 1 (March 1999): 81–88. https://doi.org/10.1016/S1388-9842(98)00004-X.
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  - Steffens, D. C., C. M. O’Connor, W. J. Jiang, C. F. Pieper, M. N. Kuchibhatla, R. M. Arias, A. Look, C. Davenport, M. B. Gonzalez, and K. R. Krishnan. “The effect of major depression on functional status in patients with coronary artery disease.” J Am Geriatr Soc 47, no. 3 (March 1999): 319–22. https://doi.org/10.1111/j.1532-5415.1999.tb02995.x.
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  - Bart, B. A., and C. M. O’Connor. “Clinical determinants of mortality in patients with cardiomyopathy.” Cardiology Review 16, no. 7 (January 1, 1999): 8–11.
  - McKenzie, M. E., A. Pothula, P. A. Gurbel, S. Y. Fuzaylov, C. M. O’Connor, W. A. Gattis, and V. L. Serebruany. “Failure of thrombin generation markers to triage patients presenting with chest pain.” Cardiology 92, no. 1 (1999): 53–58. https://doi.org/10.1159/000006946.
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  - Thel, M. C., and C. M. O’Connor. “Cardiopulmonary resuscitation: historical perspective to recent investigations.” Am Heart J 137, no. 1 (January 1999): 39–48. https://doi.org/10.1016/s0002-8703(99)70458-8.
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  - O’Connor, C. M., P. E. Carson, A. B. Miller, M. L. Pressler, R. N. Belkin, G. W. Neuberg, D. J. Frid, et al. “Effect of amlodipine on mode of death among patients with advanced heart failure in the PRAISE trial. Prospective Randomized Amlodipine Survival Evaluation.” Am J Cardiol 82, no. 7 (October 1, 1998): 881–87. https://doi.org/10.1016/s0002-9149(98)00496-2.
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  - Guyton, J. R., A. C. Goldberg, R. A. Kreisberg, D. L. Sprecher, H. R. Superko, and C. M. O’Connor. “Effectiveness of once-nightly dosing of extended-release niacin alone and in combination for hypercholesterolemia.” Am J Cardiol 82, no. 6 (September 15, 1998): 737–43. https://doi.org/10.1016/s0002-9149(98)00448-2.
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  - Krishnan, K. R., L. K. George, C. F. Pieper, W. Jiang, R. Arias, A. Look, and C. O’Connor. “Depression and social support in elderly patients with cardiac disease.” Am Heart J 136, no. 3 (September 1998): 491–95. https://doi.org/10.1016/s0002-8703(98)70225-x.
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  - Shah, B. R., C. Lin, C. Maynard, B. Bart, R. H. Selvester, L. K. Shaw, C. O’Connor, and G. S. Wagner. “Specificity of electrocardiographic myocardial infarction screening criteria in patients with nonischemic cardiomyopathies.” Am Heart J 136, no. 2 (August 1998): 314–19. https://doi.org/10.1053/hj.1998.v136.89909.
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  - Gattis, W. A., R. L. Larsen, V. Hasselblad, B. A. Bart, and C. M. O’Connor. “Is optimal angiotensin-converting enzyme inhibitor dosing neglected in elderly patients with heart failure?” Am Heart J 136, no. 1 (July 1998): 43–48. https://doi.org/10.1016/s0002-8703(98)70180-2.
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  - Serebruany, V. L., R. D. Bahr, C. M. O’Connor, D. R. Lowry, and P. A. Gurbel. “Antecedent aspirin therapy inhibits baseline platelet activity in patients presenting with acute myocardial infarction. The GUSTO-III Platelet Substudy.” Cardiology 90, no. 1 (July 1998): 37–42. https://doi.org/10.1159/000006814.
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  - O’Connor, C. M., W. A. Gattis, and K. Swedberg. “Current and novel pharmacologic approaches in advanced heart failure.” Am Heart J 135, no. 6 Pt 2 Su (June 1998): S249–63. https://doi.org/10.1016/s0002-8703(98)70254-6.
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  - Serebruany, V. L., D. Atar, M. R. Dalesandro, C. M. O’Connor, and P. A. Gurbel. “Changes in hemostasis after parenteral magnesium in myocardial ischemia-reperfusion: from animal studies to clinical trials.” Magnes Res 11, no. 2 (June 1998): 133–40.
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  - Flack, J. M., C. M. O’Connor, and J. Y. Wei. “Four commonly seen cardiovascular diseases.” Patient Care 32, no. 9 (May 15, 1998): 98–130.
  - Hassan, T. B., and D. B. Barnett. “Magnesium in in-hospital cardiac arrest.” Lancet 351, no. 9100 (February 7, 1998): 445–46. https://doi.org/10.1016/S0140-6736(05)78390-2.
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  - O’Connor, C. M., W. A. Gattis, and K. Swedberg. “Current and novel pharmacologic approaches in advanced heart failure.” American Heart Journal 135, no. 6 II SUPPL. (January 1, 1998).
  - Cuffe, M. S., and C. M. O’Connor. “Pharmacologic management of acute heart failure.” Current Opinion in Critical Care 3, no. 5 (December 1, 1997): 386–90.
  - Blumenthal, J. A., C. O’Connor, A. Hinderliter, K. Fath, S. B. Hegde, G. Miller, J. Puma, et al. “Psychosocial factors and coronary disease. A national multicenter clinical trial (ENRICHD) with a North Carolina focus.” N C Med J 58, no. 6 (November 1997): 440–44.
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  - Thel, M. C., A. L. Armstrong, S. E. McNulty, R. M. Califf, and C. M. O’Connor. “Randomised trial of magnesium in in-hospital cardiac arrest. Duke Internal Medicine Housestaff.” Lancet 350, no. 9087 (November 1, 1997): 1272–76. https://doi.org/10.1016/s0140-6736(97)05048-4.
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  - Blumenthal, J. A., W. Jiang, M. A. Babyak, D. S. Krantz, D. J. Frid, R. E. Coleman, R. Waugh, et al. “Stress management and exercise training in cardiac patients with myocardial ischemia. Effects on prognosis and evaluation of mechanisms.” Arch Intern Med 157, no. 19 (October 27, 1997): 2213–23.
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  - Bart, B. A., L. K. Shaw, C. B. McCants, D. F. Fortin, K. L. Lee, R. M. Califf, and C. M. O’Connor. “Clinical determinants of mortality in patients with angiographically diagnosed ischemic or nonischemic cardiomyopathy.” J Am Coll Cardiol 30, no. 4 (October 1997): 1002–8. https://doi.org/10.1016/s0735-1097(97)00235-0.
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  - Jiang, W., W. R. Hathaway, S. McNulty, R. L. Larsen, K. L. Hansley, Y. Zhang, and C. M. O’Connor. “Ability of heart rate variability to predict prognosis in patients with advanced congestive heart failure.” Am J Cardiol 80, no. 6 (September 15, 1997): 808–11. https://doi.org/10.1016/s0002-9149(97)00526-2.
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  - Hayano, J., W. Jiang, R. Waugh, C. O’Connor, D. Frid, and J. A. Blumenthal. “Stability over time of circadian rhythm of variability of heart rate in patients with stable coronary artery disease.” Am Heart J 134, no. 3 (September 1997): 411–18. https://doi.org/10.1016/s0002-8703(97)70075-9.
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  - O’Connor, C. M., W. R. Hathaway, E. R. Bates, J. D. Leimberger, K. N. Sigmon, D. J. Kereiakes, B. S. George, et al. “Clinical characteristics and long-term outcome of patients in whom congestive heart failure develops after thrombolytic therapy for acute myocardial infarction: development of a predictive model.” Am Heart J 133, no. 6 (June 1997): 663–73. https://doi.org/10.1016/s0002-8703(97)70168-6.
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  - Gullette, E. C., J. A. Blumenthal, M. Babyak, W. Jiang, R. A. Waugh, D. J. Frid, C. M. O’Connor, J. J. Morris, and D. S. Krantz. “Effects of mental stress on myocardial ischemia during daily life.” Jama 277, no. 19 (May 21, 1997): 1521–26.
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  - Bart, B. A., W. A. Gattis, S. J. Diem, and C. M. O’Connor. “Reasons for underuse of angiotensin-converting enzyme inhibitors in patients with heart failure and left ventricular dysfunction.” Am J Cardiol 79, no. 8 (April 15, 1997): 1118–20. https://doi.org/10.1016/s0002-9149(97)00060-x.
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  - Allan, J. J. “Amlodipine in chronic heart failure.” N Engl J Med 336, no. 14 (April 3, 1997): 1023–24.
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  - Gonzalez, M. B., T. B. Snyderman, J. T. Colket, R. M. Arias, J. W. Jiang, C. M. O’Connor, and K. R. Krishnan. “Depression in patients with coronary artery disease.” Depression 4, no. 2 (December 1, 1996): 57–62. https://doi.org/10.1002/(SICI)1522-7162(1996)4:2<57::AID-DEPR3>3.0.CO;2-C.
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  - Packer, M., C. M. O’Connor, J. K. Ghali, M. L. Pressler, P. E. Carson, R. N. Belkin, A. B. Miller, et al. “Effect of amlodipine on morbidity and mortality in severe chronic heart failure. Prospective Randomized Amlodipine Survival Evaluation Study Group.” N Engl J Med 335, no. 15 (October 10, 1996): 1107–14. https://doi.org/10.1056/NEJM199610103351504.
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  - Barefoot, J. C., M. J. Helms, D. B. Mark, J. A. Blumenthal, R. M. Califf, T. L. Haney, C. M. O’Connor, I. C. Siegler, and R. B. Williams. “Depression and long-term mortality risk in patients with coronary artery disease.” Am J Cardiol 78, no. 6 (September 15, 1996): 613–17. https://doi.org/10.1016/s0002-9149(96)00380-3.
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  - Jiang, W., M. Babyak, D. S. Krantz, R. A. Waugh, R. E. Coleman, M. M. Hanson, D. J. Frid, et al. “Mental stress--induced myocardial ischemia and cardiac events.” Jama 275, no. 21 (June 5, 1996): 1651–56. https://doi.org/10.1001/jama.275.21.1651.
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  - O’Connor, C. M., R. B. Meese, S. McNulty, K. D. Lucas, R. J. Carney, R. M. LeBoeuf, W. Maddox, et al. “A randomized factorial trial of reperfusion strategies and aspirin dosing in acute myocardial infarction. The DUCCS-II Investigators.” Am J Cardiol 77, no. 10 (April 15, 1996): 791–97. https://doi.org/10.1016/s0002-9149(97)89171-0.
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  - Mahaffey, K. W., C. B. Granger, R. Collins, C. M. O’Connor, E. M. Ohman, S. D. Bleich, J. J. Col, and R. M. Califf. “Overview of randomized trials of intravenous heparin in patients with acute myocardial infarction treated with thrombolytic therapy.” Am J Cardiol 77, no. 8 (March 15, 1996): 551–56. https://doi.org/10.1016/s0002-9149(97)89305-8.
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  - Gonzalez, M. B., T. B. Snyderman, J. T. Colket, R. M. Arias, J. W. Jiang, C. M. O’Connor, and K. R. Krishnan. “Depression in patients with coronary artery disease.” Depression 4, no. 2 (1996): 57–62. https://doi.org/10.1002/(SICI)1522-7162(1996)4:2<57::AID-DEPR3>3.0.CO;2-C.
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  - Jiang, W., M. A. Trauner, R. E. Coleman, R. A. Waugh, M. W. Hanson, D. J. Frid, B. G. Phillips, J. J. Morris, C. O’Connor, and J. A. Blumenthal. “Association of physical fitness and transient myocardial ischemia in patients with coronary artery disease.” J Cardiopulm Rehabil 15, no. 6 (November 1995): 431–38. https://doi.org/10.1097/00008483-199511000-00007.
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  - Blumenthal, J. A., W. Jiang, R. A. Waugh, D. J. Frid, J. J. Morris, R. E. Coleman, M. Hanson, M. Babyak, E. T. Thyrum, and D. S. Krantz. “Mental stress-induced ischemia in the laboratory and ambulatory ischemia during daily life. Association and hemodynamic features.” Circulation 92, no. 8 (October 15, 1995): 2102–8. https://doi.org/10.1161/01.cir.92.8.2102.
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  - Thel, M. C., and C. M. O’Connor. “Magnesium in acute myocardial infarction.” Coron Artery Dis 6, no. 10 (October 1995): 831–37. https://doi.org/10.1097/00019501-199510000-00012.
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  - Jiang, W., J. A. Blumenthal, M. W. Hanson, R. E. Coleman, C. M. O’Connor, D. Frid, J. J. Morris, and R. A. Waugh. “Relative importance of electrode placement over number of channels in transient myocardial ischemia detection by Holter monitoring.” Am J Cardiol 76, no. 5 (August 15, 1995): 350–54. https://doi.org/10.1016/s0002-9149(99)80099-x.
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  - Mörike, K., and G. Mikus. “Zofenopril after anterior myocardial infarction.” N Engl J Med 332, no. 25 (June 22, 1995): 1715.
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  - Campbell, P. T., J. S. Li, T. C. Wall, C. M. O’Connor, P. Van Trigt, R. T. Kenney, O. Melhus, and G. R. Corey. “Cytomegalovirus pericarditis: a case series and review of the literature.” Am J Med Sci 309, no. 4 (April 1995): 229–34. https://doi.org/10.1097/00000441-199504000-00009.
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  - Selker, H. P., J. R. Beshansky, C. H. Schmid, J. L. Griffith, W. T. Longstreth, C. M. O’Connor, L. R. Caplan, E. W. Massey, R. B. D’Agostino, and M. M. Laks. “Presenting pulse pressure predicts thrombolytic therapy-related intracranial hemorrhage. Thrombolytic Predictive Instrument (TPI) Project results.” Circulation 90, no. 4 (October 1994): 1657–61. https://doi.org/10.1161/01.cir.90.4.1657.
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  - Larsen, R. L., V. S. Behar, S. R. Brazer, J. Chen, and C. M. O’Connor. “Chest pain presenting as ischemic heart disease. Congenital absence of the pericardium.” N C Med J 55, no. 7 (July 1994): 306–8.
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  - O’Connor, C. M., R. Meese, R. Carney, J. Smith, E. Conn, J. Burks, C. Hartman, S. Roark, N. Shadoff, and M. Heard. “A randomized trial of intravenous heparin in conjunction with anistreplase (anisoylated plasminogen streptokinase activator complex) in acute myocardial infarction: the Duke University Clinical Cardiology Study (DUCCS) 1.” J Am Coll Cardiol 23, no. 1 (January 1994): 11–18. https://doi.org/10.1016/0735-1097(94)90496-0.
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  - Van Trigt, P., J. Douglas, P. K. Smith, P. T. Campbell, T. C. Wall, R. T. Kenney, C. M. O’Connor, K. H. Sheikh, and G. R. Corey. “A prospective trial of subxiphoid pericardiotomy in the diagnosis and treatment of large pericardial effusion. A follow-up report.” Ann Surg 218, no. 6 (December 1993): 777–82. https://doi.org/10.1097/00000658-199312000-00012.
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  - Jiang, W., J. Hayano, E. R. Coleman, M. W. Hanson, D. J. Frid, C. O’Connor, D. Thurber, R. A. Waugh, and J. A. Blumenthal. “Relation of cardiovascular responses to mental stress and cardiac vagal activity in coronary artery disease.” Am J Cardiol 72, no. 7 (September 1, 1993): 551–54. https://doi.org/10.1016/0002-9149(93)90350-l.
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  - Corey, G. R., P. T. Campbell, P. Van Trigt, R. T. Kenney, C. M. O’Connor, K. H. Sheikh, J. A. Kisslo, and T. C. Wall. “Etiology of large pericardial effusions.” Am J Med 95, no. 2 (August 1993): 209–13. https://doi.org/10.1016/0002-9343(93)90262-n.
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  - Kenney, R. T., J. S. Li, W. A. Clyde, T. C. Wall, C. M. O’Connor, P. T. Campbell, P. Van Trigt, and G. R. Corey. “Mycoplasmal pericarditis: evidence of invasive disease.” Clin Infect Dis 17 Suppl 1 (August 1993): S58–62. https://doi.org/10.1093/clinids/17.supplement_1.s58.
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  - Krucoff, M. W., M. A. Croll, J. E. Pope, C. B. Granger, C. M. O’Connor, K. N. Sigmon, B. L. Wagner, J. A. Ryan, K. L. Lee, and D. J. Kereiakes. “Continuous 12-lead ST-segment recovery analysis in the TAMI 7 study. Performance of a noninvasive method for real-time detection of failed myocardial reperfusion.” Circulation 88, no. 2 (August 1993): 437–46. https://doi.org/10.1161/01.cir.88.2.437.
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  - Slaughter, T. F., E. A. Mody, H. N. Oldham, J. G. Reves, C. M. O’Connor, J. K. Parker, and C. S. Greenberg. “Management of a patient with type IIC von Willebrand's disease during coronary artery bypass graft surgery.” Anesthesiology 78, no. 1 (January 1993): 195–97. https://doi.org/10.1097/00000542-199301000-00027.
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  - Wall, T. C., P. T. Campbell, C. M. O’Connor, P. Van Trigt, R. T. Kenney, K. H. Sheikh, J. A. Kisslo, and G. R. Corey. “Diagnosis and management (by subxiphoid pericardiotomy) of large pericardial effusions causing cardiac tamponade.” Am J Cardiol 69, no. 12 (April 15, 1992): 1075–78. https://doi.org/10.1016/0002-9149(92)90866-w.
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  - Campbell, P. T., P. Van Trigt, T. C. Wall, R. T. Kenney, C. M. O’Connor, K. H. Sheikh, J. A. Kisslo, M. E. Baker, and G. R. Corey. “Subxiphoid pericardiotomy in the diagnosis and management of large pericardial effusions associated with malignancy.” Chest 101, no. 4 (April 1992): 938–43. https://doi.org/10.1378/chest.101.4.938.
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  - Ortel, T. L., J. P. Gockerman, R. M. Califf, R. L. McCann, C. M. O’Connor, D. M. Metzler, and C. S. Greenberg. “Parenteral anticoagulation with the heparinoid Lomoparan (Org 10172) in patients with heparin induced thrombocytopenia and thrombosis.” Thromb Haemost 67, no. 3 (March 2, 1992): 292–96.
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  - O’Connor, C. M., and R. M. Califf. “Aggressive therapy of acute MI in the elderly.” Hosp Pract (Off Ed) 27, no. 2 (February 15, 1992): 59-passim. https://doi.org/10.1080/21548331.1992.11705360.
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  - Uglietta, J. P., C. M. O’Connor, O. B. Boyko, H. Aldrich, E. W. Massey, and E. R. Heinz. “CT patterns of intracranial hemorrhage complicating thrombolytic therapy for acute myocardial infarction.” Radiology 181, no. 2 (November 1991): 555–59. https://doi.org/10.1148/radiology.181.2.1924804.
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  - Wallis, D. E., W. E. Boden, R. Califf, M. H. Crawford, A. H. Hakki, A. S. Iskandrian, A. Labovitz, C. O’Connor, R. Sutton, and P. J. Scanlon. “Failure of adjuvant heparin to reduce myocardial ischemia in the early treatment of patients with unstable angina.” Am Heart J 122, no. 4 Pt 1 (October 1991): 949–54. https://doi.org/10.1016/0002-8703(91)90456-r.
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  - O’Connor, C. M., R. M. Califf, E. W. Massey, D. B. Mark, D. J. Kereiakes, R. J. Candela, C. Abbottsmith, B. George, R. S. Stack, and L. Aronson. “Stroke and acute myocardial infarction in the thrombolytic era: clinical correlates and long-term prognosis.” J Am Coll Cardiol 16, no. 3 (September 1990): 533–40. https://doi.org/10.1016/0735-1097(90)90338-p.
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  - Blumenthal, J. A., and C. O’Connor. “Stress and silent myocardial ischemia. A new research study at Duke University Medical Center.” N C Med J 51, no. 4 (April 1990): 135–38.
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  - Mark, D. B., M. A. Hlatky, C. M. O’Connor, D. B. Pryor, T. C. Wall, M. B. Honan, H. R. Phillips, and R. M. Califf. “Administration of thrombolytic therapy in the community hospital: established principles and unresolved issues.” J Am Coll Cardiol 12, no. 6 Suppl A (December 1988): 32A-43A. https://doi.org/10.1016/0735-1097(88)92639-3.
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  - Stack, R. S., R. M. Califf, T. Hinohara, H. R. Phillips, D. B. Pryor, C. A. Simonton, E. B. Carlson, K. G. Morris, V. S. Behar, and Y. Kong. “Survival and cardiac event rates in the first year after emergency coronary angioplasty for acute myocardial infarction.” J Am Coll Cardiol 11, no. 6 (June 1988): 1141–49. https://doi.org/10.1016/0735-1097(88)90274-4.
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  - Simonton, C. A., D. B. Mark, T. Hinohara, D. S. Rendall, H. R. Phillips, R. H. Peter, V. S. Behar, Y. Kong, W. G. O’Callaghan, and C. O’Connor. “Late restenosis after emergent coronary angioplasty for acute myocardial infarction: comparison with elective coronary angioplasty.” J Am Coll Cardiol 11, no. 4 (April 1988): 698–705. https://doi.org/10.1016/0735-1097(88)90198-2.
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  - Hlatky, M. A., H. Cotugno, C. O’Connor, D. B. Mark, D. B. Pryor, and R. M. Califf. “Adoption of thrombolytic therapy in the management of acute myocardial infarction.” Am J Cardiol 61, no. 8 (March 1, 1988): 510–14. https://doi.org/10.1016/0002-9149(88)90755-2.
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  - Hlatky, M. A., H. E. Cotugno, D. B. Mark, C. O’Connor, R. M. Califf, and D. B. Pryor. “Trends in physician management of uncomplicated acute myocardial infarction, 1970 to 1987.” Am J Cardiol 61, no. 8 (March 1, 1988): 515–18. https://doi.org/10.1016/0002-9149(88)90756-4.
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  - Stack, R. S., C. M. O’Connor, D. B. Mark, T. Hinohara, H. R. Phillips, M. M. Lee, N. M. Ramirez, W. G. O’Callaghan, C. A. Simonton, and E. B. Carlson. “Coronary perfusion during acute myocardial infarction with a combined therapy of coronary angioplasty and high-dose intravenous streptokinase.” Circulation 77, no. 1 (January 1988): 151–61. https://doi.org/10.1161/01.cir.77.1.151.
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  - Boswick, J. M., K. L. Lee, L. G. Aronson, C. M. O’Connor, M. B. Honan, R. M. Califf, and D. B. Pryor. “USE OF COMPUTERIZED STATISTICAL MODELS TO EDUCATE MEDICAL HOUSESTAFF IN ESTIMATING CLINICAL OUTCOMES.” Proceedings Annual Symposium on Computer Applications in Medical Care, December 1, 1987, 162–65.
  - Patronas, N. J., G. Di Chiro, R. A. Brooks, R. L. DeLaPaz, P. L. Kornblith, B. H. Smith, H. V. Rizzoli, et al. “Work in progress: [18F] fluorodeoxyglucose and positron emission tomography in the evaluation of radiation necrosis of the brain.” Radiology 144, no. 4 (September 1982): 885–89. https://doi.org/10.1148/radiology.144.4.6981123.
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  - Brooks, R. A., L. G. Mitchell, C. M. O’Connor, and G. Di Chiro. “On the relationship between computed tomography numbers and specific gravity.” Phys Med Biol 26, no. 1 (January 1981): 141–47. https://doi.org/10.1088/0031-9155/26/1/014.
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  - Rieth, K. G., K. Fujiwara, G. Di Chiro, I. Klatzo, R. A. Brooks, G. S. Johnston, C. M. O’Connor, and L. G. Mitchell. “Serial measurements of CT attenuation and specific gravity in experimental cerebral edema.” Radiology 135, no. 2 (May 1980): 343–48. https://doi.org/10.1148/radiology.135.2.6768102.
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  - Sheridan, W. T., M. R. Keller, C. M. O’Connor, R. A. Brooks, and K. M. Hanson. “Evaluation of edge-induced streaking artifacts in CT scanners.” Med Phys 7, no. 2 (March 1980): 108–11. https://doi.org/10.1118/1.594673.
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  - Koenig, Harold G., Christopher M. O’Connor, Steven A. Guarisco, K Michael Zabel, and Stephen M. Ford. “Depressive Disorder in Older Medical Inpatients on General Medicine and Cardiology Services at a University Teaching Hospital.” Am J Geriatr Psychiatry 1, no. 3 (n.d.): 197–210. https://doi.org/10.1097/00019442-199300130-00004.
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- Conference Papers
  - Tehrani, Behnam N., Alexander G. Truesdell, Matthew W. Sherwood, Shashank Desai, Henry A. Tran, Kelly C. Epps, Ramesh Singh, et al. “Standardized Team-Based Care for Cardiogenic Shock.” In J Am Coll Cardiol, 73:1659–69, 2019. https://doi.org/10.1016/j.jacc.2018.12.084.
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  - Mentz, Robert J., Christopher M. O’Connor, Bradi B. Granger, Hongqiu Yang, Chetan B. Patel, Karen E. Steinhauser, Mona Fiuzat, et al. “Palliative care and hospital readmissions in patients with advanced heart failure: Insights from the PAL-HF trial.” In Am Heart J, 204:202–4, 2018. https://doi.org/10.1016/j.ahj.2018.07.010.
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  - Pokorney, Sean D., Sana M. Al-Khatib, Jie-Lena Sun, Phillip Schulte, Christopher M. O’Connor, John R. Teerlink, Paul W. Armstrong, et al. “Sudden cardiac death after acute heart failure hospital admission: insights from ASCEND-HF.” In Eur J Heart Fail, 20:525–32, 2018. https://doi.org/10.1002/ejhf.1078.
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  - DeVore, Adam D., Vic Hasselblad, Robert J. Mentz, Christopher M. O’Connor, Paul W. Armstrong, John J. McMurray, Justin A. Ezekowitz, et al. “Loop diuretic dose adjustments after a hospitalization for heart failure: insights from ASCEND-HF.” In Eur J Heart Fail, 17:340–46, 2015. https://doi.org/10.1002/ejhf.235.
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  - Valente, Mattia A. E., Adriaan A. Voors, Kevin Damman, Dirk J. Van Veldhuisen, Barrie M. Massie, Christopher M. O’Connor, Marco Metra, et al. “Diuretic response in acute heart failure: clinical characteristics and prognostic significance.” In Eur Heart J, 35:1284–93, 2014. https://doi.org/10.1093/eurheartj/ehu065.
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  - Wilcox, Jane E., Gregg C. Fonarow, Yan Zhang, Nancy M. Albert, Anne B. Curtis, Mihai Gheorghiade, J Thomas Heywood, et al. “Clinical effectiveness of cardiac resynchronization and implantable cardioverter-defibrillator therapy in men and women with heart failure: findings from IMPROVE HF.” In Circ Heart Fail, 7:146–53, 2014. https://doi.org/10.1161/CIRCHEARTFAILURE.113.000789.
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Teaching & Mentoring
Recent Courses
- CRSP 301B: Research in Clinical Research 2020

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