Christopher Michael O'Connor

Christopher Michael O'Connor
Richard Sean Stack, M.D. Distinguished Professor

Dr. O’Connor’s research interests include: acute heart failure; co-morbidities in heart failure; clinical trials; biomarkers; and novel pharmacological and non-pharmacological approaches for the treatment of heart failure.

Current Appointments & Affiliations

Richard Sean Stack, M.D. Distinguished Professor, Medicine, Clinical Pharmacology, Medicine 2014
Adjunct Professor in the Department of Medicine, Medicine, Clinical Pharmacology, Medicine 2016

Contact Information

7401 Hosp North, Durham, NC 27710
Duke Box 3356, Durham, NC 27710
oconn002@mc.duke.edu (919) 681-6195

Background
Education, Training, & Certifications
- Fellow in Cardiology, Medicine, Duke University 1988 - 1989
- Chief Medical Resident - VAMC, Medicine, Duke University 1987 - 1988
- Cardiology Fellow, Medicine, Duke University 1986 - 1987
- Medical Resident, Medicine, Duke University 1983 - 1986
- M.D., University of Maryland, College Park 1983
Duke Appointment History
- Member in the Duke Clinical Research Institute, Duke Clinical Research Institute, Institutes and Centers 1985 - 2016
- Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Clinical Science Departments 2001 - 2016
- Director, of the Heart Center/Cardiovascular CSU, Medicine, Clinical Science Departments 2007 - 2016
- Adjunct Professor in the Department of Medicine, Medicine, Cardiology, Medicine 2015 - 2016
- Professor of Medicine, Medicine, Cardiology, Medicine 2003 - 2015
- Chief, Division of Clinical Pharmacology in the Department of Medicine, Medicine, Clinical Pharmacology, Medicine 2001 - 2015
- Chief, Division of Cardiology, Medicine, Cardiology, Medicine 2012 - 2015
- Acting Chief of the Division of Cardiology, Medicine, Cardiology, Medicine 2010 - 2012
- Associate Professor of Medicine, Medicine, Cardiology, Medicine 1999 - 2003
- Associate Professor of Medicine, Medicine, Cardiology, Medicine 1996 - 1999
- Assistant Professor of Medicine, Medicine, Cardiology, Medicine 1990 - 1996
- Associate in the Department of Medicine, Medicine, Clinical Science Departments 1989 - 1990
Recognition
In the News
- NOV 19, 2019
  
  Global List of Highly Cited Puts Duke in Top Ten
- NOV 27, 2018
  
  Duke Faculty Plentiful On ‘Highly Cited’ List
Expertise
Subject Headings
Research
Selected Grants
- Duke-UNC Clinical Hematology and Transfusion Research Career Development Program awarded by National Institutes of Health 2006 - 2019
- STICHES awarded by National Institutes of Health 2011 - 2019
- GUIDing Evidence Based Therapy Using Biomarker Intensified Treatment (CCC) awarded by National Institutes of Health 2012 - 2017
- Palliative Care in Heart Failure (PAL-HF) awarded by National Institutes of Health 2011 - 2016
- UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program awarded by University of North Carolina - Chapel Hill 2011 - 2016
- Coping Skills Training in Heart Failure: Outcomes and Mechanisms awarded by National Institutes of Health 2009 - 2015
- Responses of Myocardial Ischemia to Sertraline Treatment awarded by National Institutes of Health 2006 - 2013
- Heart Failure Clinical Research Network awarded by National Institutes of Health 2006 - 2011
- STICH Trial - Coordinating Center awarded by National Institutes of Health 2002 - 2011
- Pharmacometabolomics Research Network awarded by National Institutes of Health 2010 - 2011
- Safety and Efficacy of Sertraline for Depression CHF awarded by National Institutes of Health 2003 - 2011
- A CHF Trial Investigating Outcomes of Exercise Training awarded by National Institutes of Health 2002 - 2010
- HF Action Supplement awarded by National Institutes of Health 2002 - 2010
- Inflammation & Prognosis in Decompensated Heart Failure awarded by National Institutes of Health 2004 - 2010
- ESCAPE - Evaluation Study of Congestive Heart Failure and Pulmonary Artery Cathetorization Effectiveness awarded by National Institutes of Health 1999 - 2008
- ESCAPE Mechanistic Substudy Grant Application awarded by National Institutes of Health 2001 - 2006
- Enhancing Recovery In Coronary Heart Disease Patients awarded by National Institutes of Health 1995 - 2005
- Stress & Congestive Heart Failure:Prognosis & Mechanisms awarded by National Institutes of Health 1999 - 2005
- same awarded by Department of Veterans Affairs 1999 - 2004
- Inflammatory Biomarkers in Depressed CHF Patients awarded by National Institutes of Health 2003 - 2004
- Depression In Elderly Cardiac Patients awarded by National Institutes of Health 1994 - 2003
- Beta-Blocker Evaluation Of Survival Trial (Best) awarded by Department of Veterans Affairs 1995 - 2001
- Heart Failure Specialized Center Of Research awarded by National Institutes of Health 1995 - 1999
External Relationships
- Arca Biopharma, Inc.
- Bayer
- Bristol Myers Squibb Foundation
- Dey, L.P. (Merck)
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Psotka, Mitchell A., William T. Abraham, Mona Fiuzat, Gerasimos Filippatos, JoAnn Lindenfeld, Tariq Ahmad, Ankeet S. Bhatt, et al. “Conduct of Clinical Trials in the Era of COVID-19: JACC Scientific Expert Panel.” J Am Coll Cardiol 76, no. 20 (November 17, 2020): 2368–78. https://doi.org/10.1016/j.jacc.2020.09.544.
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  - Lam, Carolyn S. P., Anna Giczewska, Karen Sliwa, Frank Edelmann, Jens Refsgaard, Edimar Bocchi, Justin A. Ezekowitz, et al. “Clinical Outcomes and Response to Vericiguat According to Index Heart Failure Event: Insights From the VICTORIA Trial.” Jama Cardiology, November 13, 2020. https://doi.org/10.1001/jamacardio.2020.6455.
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  - Ezekowitz, Justin A., Christopher M. O’Connor, Richard W. Troughton, Wendimagegn G. Alemayehu, Cynthia M. Westerhout, Adriaan A. Voors, Javed Butler, et al. “N-Terminal Pro-B-Type Natriuretic Peptide and Clinical Outcomes: Vericiguat Heart Failure With Reduced Ejection Fraction Study.” Jacc Heart Fail 8, no. 11 (November 2020): 931–39. https://doi.org/10.1016/j.jchf.2020.08.008.
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  - O’Connor, Christopher M. “Personalized Therapeutic Approach: Gun Control for Shotgun Therapy.” Jacc Heart Fail 8, no. 11 (November 2020): 954–55. https://doi.org/10.1016/j.jchf.2020.09.002.
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  - Armstrong, Paul W., Carolyn S. P. Lam, Kevin J. Anstrom, Justin Ezekowitz, Adrian F. Hernandez, Christopher M. O’Connor, Burkert Pieske, et al. “Effect of Vericiguat vs Placebo on Quality of Life in Patients With Heart Failure and Preserved Ejection Fraction: The VITALITY-HFpEF Randomized Clinical Trial.” Jama 324, no. 15 (October 20, 2020): 1512–21. https://doi.org/10.1001/jama.2020.15922.
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  - Armstrong, Paul W., Kevin J. Anstrom, Christopher M. O’Connor, and Christopher M. VICTORIA Study Group. “Vericiguat in Heart Failure with Reduced Ejection Fraction. Reply.” N Engl J Med 383, no. 15 (October 8, 2020): 1497–98. https://doi.org/10.1056/NEJMc2027731.
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  - Fudim, Marat, Joseph B. Lerman, Courtney Page, Brooke Alhanti, Robert M. Califf, Justin A. Ezekowitz, Nicolas Girerd, et al. “Plasma Volume Status and Its Association With In-Hospital and Postdischarge Outcomes in Decompensated Heart Failure.” J Card Fail, October 7, 2020. https://doi.org/10.1016/j.cardfail.2020.09.478.
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  - Psotka, Mitchell A., Mona Fiuzat, Marco Metra, and Christopher M. O’Connor. “Reply: Potential Mechanisms to Improve Heart Failure Clinical Trial Publication Rates.” J Am Coll Cardiol 76, no. 14 (October 6, 2020): 1717–18. https://doi.org/10.1016/j.jacc.2020.08.013.
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  - Perego, Carlotta, Marco Sbolli, Claudia Specchia, Mona Fiuzat, Zachary R. McCaw, Marco Metra, Chiara Oriecuia, et al. “Utility of Restricted Mean Survival Time Analysis for Heart Failure Clinical Trial Evaluation and Interpretation.” Jacc Heart Fail, October 2, 2020. https://doi.org/10.1016/j.jchf.2020.07.005.
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  - O’Connor, Christopher M. “Convalescence From COVID Research: Lessons From the Heart Failure Community.” Jacc Heart Fail 8, no. 10 (October 2020): 870–71. https://doi.org/10.1016/j.jchf.2020.08.005.
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  - Angraal, Suveen, César Caraballo, Peter Kahn, Ambika Bhatnagar, Bikramjot Singh, F Perry Wilson, Mona Fiuzat, et al. “Geographical affiliation with top 10 NIH-funded academic medical centers and differences between mortality from cardiovascular disease and cancer.” Am Heart J 230 (September 18, 2020): 54–58. https://doi.org/10.1016/j.ahj.2020.08.014.
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  - O’Connor, Christopher M., and Cleveland Francis. “The Journey of an American Black Cardiologist.” Jacc Heart Fail 8, no. 9 (September 2020): 780–81. https://doi.org/10.1016/j.jchf.2020.08.001.
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  - Psotka, Mitchell A., Mona Fiuzat, Scott D. Solomon, Cynthia Chauhan, G Michael Felker, Javed Butler, John R. Teerlink, Shashank S. Sinha, Christopher M. O’Connor, and Marvin A. Konstam. “Challenges and Potential Improvements to Patient Access to Pharmaceuticals: Examples From Cardiology.” Circulation 142, no. 8 (August 25, 2020): 790–98. https://doi.org/10.1161/CIRCULATIONAHA.119.044976.
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  - Reza, Nosheen, Ayman Samman Tahhan, Nadim Mahmud, Ersilia M. DeFilippis, Alaaeddin Alrohaibani, Muthiah Vaduganathan, Stephen J. Greene, et al. “Representation of Women Authors in International Heart Failure Guidelines and Contemporary Clinical Trials.” Circulation. Heart Failure 13, no. 8 (August 6, 2020): e006605. https://doi.org/10.1161/circheartfailure.119.006605.
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  - Abraham, William T., Mona Fiuzat, Mitchell A. Psotka, and Christopher M. O’Connor. “Heart Failure Collaboratory Statement on Remote Monitoring and Social Distancing in the Landscape of COVID-19.” Jacc Heart Fail 8, no. 8 (August 2020): 692–94. https://doi.org/10.1016/j.jchf.2020.06.006.
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  - Damluji, Abdulla A., Michael Fabbro, Richard H. Epstein, Stefan Rayer, Ying Wang, Mauro Moscucci, Mauricio G. Cohen, et al. “Transcatheter Aortic Valve Replacement in Low-Population Density Areas: Assessing Healthcare Access for Older Adults With Severe Aortic Stenosis.” Circ Cardiovasc Qual Outcomes 13, no. 8 (August 2020): e006245. https://doi.org/10.1161/CIRCOUTCOMES.119.006245.
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  - Fiuzat, Mona, Justin Ezekowitz, Wendimagegn Alemayehu, Cynthia M. Westerhout, Marco Sbolli, Dario Cani, David J. Whellan, et al. “Assessment of Limitations to Optimization of Guideline-Directed Medical Therapy in Heart Failure From the GUIDE-IT Trial: A Secondary Analysis of a Randomized Clinical Trial.” Jama Cardiol 5, no. 7 (July 1, 2020): 757–64. https://doi.org/10.1001/jamacardio.2020.0640.
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  - O’Connor, Christopher M. “COVID-19 Fatigue: Not So Fast.” Jacc Heart Fail 8, no. 7 (July 2020): 592–94. https://doi.org/10.1016/j.jchf.2020.06.001.
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  - Psotka, Mitchell A., Federica Latta, Dario Cani, Mona Fiuzat, Marco Sbolli, Scott Barnett, Marco Metra, and Christopher M. O’Connor. “Publication Rates of Heart Failure Clinical Trials Remain Low.” J Am Coll Cardiol 75, no. 25 (June 30, 2020): 3151–61. https://doi.org/10.1016/j.jacc.2020.04.068.
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  - Bhatt, Ankeet S., Andrew P. Ambrosy, Allison Dunning, Adam D. DeVore, Javed Butler, Shelby Reed, Adriaan Voors, et al. “The burden of non-cardiac comorbidities and association with clinical outcomes in an acute heart failure trial - insights from ASCEND-HF.” Eur J Heart Fail 22, no. 6 (June 2020): 1022–31. https://doi.org/10.1002/ejhf.1795.
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  - Damluji, Abdulla A., Gregory Rodriguez, Thomas Noel, Lakerria Davis, Vishal Dahya, Behnam Tehrani, Kelly Epps, et al. “Sarcopenia and health-related quality of life in older adults after transcatheter aortic valve replacement.” Am Heart J 224 (June 2020): 171–81. https://doi.org/10.1016/j.ahj.2020.03.021.
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  - Fiuzat, Mona, Naomi Lowy, Norman Stockbridge, Marco Sbolli, Federica Latta, JoAnn Lindenfeld, Eldrin F. Lewis, et al. “Endpoints in Heart Failure Drug Development: History and Future.” Jacc Heart Fail 8, no. 6 (June 2020): 429–40. https://doi.org/10.1016/j.jchf.2019.12.011.
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  - O’Connor, Christopher M. “Heart Failure Editorial Emergencies in the COVID-19 Era.” Jacc. Heart Failure 8, no. 6 (June 2020): 518. https://doi.org/10.1016/j.jchf.2020.04.002.
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  - Sbolli, Marco, Mona Fiuzat, Dario Cani, and Christopher M. O’Connor. “Depression and heart failure: the lonely comorbidity.” Eur J Heart Fail, May 29, 2020. https://doi.org/10.1002/ejhf.1865.
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  - Reddy, Yogesh N. V., Barry A. Borlaug, Christopher M. O’Connor, and Bernard J. Gersh. “Novel approaches to the management of chronic systolic heart failure: future directions and unanswered questions.” Eur Heart J 41, no. 18 (May 7, 2020): 1764–74. https://doi.org/10.1093/eurheartj/ehz364.
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  - Abraham, William T., Mona Fiuzat, Mitchell A. Psotka, and Christopher M. O’Connor. “Heart Failure Collaboratory Statement on Clinical Trials in the Landscape of COVID-19.” Jacc. Heart Failure 8, no. 5 (May 2020): 423–25. https://doi.org/10.1016/j.jchf.2020.03.005.
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  - Armstrong, Paul W., Burkert Pieske, Kevin J. Anstrom, Justin Ezekowitz, Adrian F. Hernandez, Javed Butler, Carolyn S. P. Lam, et al. “Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction.” The New England Journal of Medicine 382, no. 20 (May 2020): 1883–93. https://doi.org/10.1056/nejmoa1915928.
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  - Butler, Javed, Muhammad Shahzeb Khan, Stefan D. Anker, Gregg C. Fonarow, Raymond J. Kim, Savina Nodari, Christopher M. O’Connor, et al. “Effects of Elamipretide on Left Ventricular Function in Patients With Heart Failure With Reduced Ejection Fraction: The PROGRESS-HF Phase 2 Trial.” J Card Fail 26, no. 5 (May 2020): 429–37. https://doi.org/10.1016/j.cardfail.2020.02.001.
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  - Cooper, Lauren B., Mitchell A. Psotka, Shashank Sinha, Brahmajee K. Nallamothu, Christopher R. deFilippi, Wayne Batchelor, Christopher M. O’Connor, and Abdulla A. Damluji. “Specificity of administrative coding for older adults with acute heart failure hospitalizations.” Am Heart J 223 (May 2020): 1–2. https://doi.org/10.1016/j.ahj.2020.02.004.
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  - Ibrahim, Nasrien E., John C. Burnett, Javed Butler, Alexander Camacho, G Michael Felker, Mona Fiuzat, Christopher O’Connor, et al. “Natriuretic Peptides as Inclusion Criteria in Clinical Trials: A JACC: Heart Failure Position Paper.” Jacc Heart Fail 8, no. 5 (May 2020): 347–58. https://doi.org/10.1016/j.jchf.2019.12.010.
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  - O’Connor, Christopher M. “Heart Failure Multidisciplinary Teams and New Zealand Rugby: What Can We Learn From the "All Blacks" Rugby Team?” Jacc Heart Fail 8, no. 4 (April 2020): 341–42. https://doi.org/10.1016/j.jchf.2020.02.003.
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  - Pandhi, Paloma, Jozine M. Ter Maaten, Johanna E. Emmens, Joachim Struck, Andreas Bergmann, John G. Cleland, Michael M. Givertz, et al. “Clinical value of pre-discharge bio-adrenomedullin as a marker of residual congestion and high risk of heart failure hospital readmission.” Eur J Heart Fail 22, no. 4 (April 2020): 683–91. https://doi.org/10.1002/ejhf.1693.
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  - Truby, Lauren K., Christopher O’Connor, Mona Fiuzat, Amanda Stebbins, Adrian Coles, Chetan B. Patel, Bradi Granger, et al. “Sex Differences in Quality of Life and Clinical Outcomes in Patients With Advanced Heart Failure: Insights From the PAL-HF Trial.” Circ Heart Fail 13, no. 4 (April 2020): e006134. https://doi.org/10.1161/CIRCHEARTFAILURE.119.006134.
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  - Armstrong, Paul W., Burkert Pieske, and Christopher M. O’Connor. “Effects of vericiguat in heart failure with reduced ejection fraction: do not forget sST2. Reply.” Eur J Heart Fail, February 21, 2020. https://doi.org/10.1002/ejhf.1765.
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  - O’Connor, Christopher M. “The Heart Failure High Five: Medical Therapy and Policy: 2019.” Jacc Heart Fail 8, no. 1 (January 2020): 81–82. https://doi.org/10.1016/j.jchf.2019.11.008.
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  - Psotka, Mitchell A., Gregg C. Fonarow, Larry A. Allen, Karen E. Joynt Maddox, Mona Fiuzat, Paul Heidenreich, Adrian F. Hernandez, Marvin A. Konstam, Clyde W. Yancy, and Christopher M. O’Connor. “The Hospital Readmissions Reduction Program: Nationwide Perspectives and Recommendations: A JACC: Heart Failure Position Paper.” Jacc Heart Fail 8, no. 1 (January 2020): 1–11. https://doi.org/10.1016/j.jchf.2019.07.012.
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  - Tehrani, B. N., A. A. Damluji, M. W. Sherwood, C. Rosner, A. G. Truesdell, K. C. Epps, E. Howard, et al. “Transradial access in acute myocardial infarction complicated by cardiogenic shock: Stratified analysis by shock severity.” Catheterization and Cardiovascular Interventions, January 1, 2020. https://doi.org/10.1002/ccd.29098.
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  - Yang, Siyun, Monique Anderson Starks, Adrian F. Hernandez, Elizabeth L. Turner, Robert M. Califf, Christopher M. O’Connor, Robert J. Mentz, and Kingshuk Roy Choudhury. “Impact of baseline covariate imbalance on bias in treatment effect estimation in cluster randomized trials: Race as an example.” Contemp Clin Trials 88 (January 2020): 105775. https://doi.org/10.1016/j.cct.2019.04.016.
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  - Butler, Javed, Milton Packer, Stephen J. Greene, Mona Fiuzat, Stefan D. Anker, Kevin J. Anstrom, Peter E. Carson, et al. “Heart Failure End Points in Cardiovascular Outcome Trials of Sodium Glucose Cotransporter 2 Inhibitors in Patients With Type 2 Diabetes Mellitus: A Critical Evaluation of Clinical and Regulatory Issues.” Circulation 140, no. 25 (December 17, 2019): 2108–18. https://doi.org/10.1161/CIRCULATIONAHA.119.042155.
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  - Caraballo, César, Nihar R. Desai, Hillary Mulder, Brooke Alhanti, F Perry Wilson, Mona Fiuzat, G Michael Felker, et al. “Clinical Implications of the New York Heart Association Classification.” J Am Heart Assoc 8, no. 23 (December 3, 2019): e014240. https://doi.org/10.1161/JAHA.119.014240.
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  - DeVore, Adam D., Eric Yow, Mitchell W. Krucoff, Matthew W. Sherwood, Linda K. Shaw, Karen Chiswell, Christopher M. O’Connor, Erik Magnus Ohman, and Eric J. Velazquez. “Percutaneous coronary intervention outcomes in patients with stable coronary disease and left ventricular systolic dysfunction.” Esc Heart Fail 6, no. 6 (December 2019): 1233–42. https://doi.org/10.1002/ehf2.12510.
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  - O’Connor, Christopher M. “N-1 and Sequencing Clinical Heart Failure Trials: Charting the Path for Future Clinical Care.” Jacc Heart Fail 7, no. 12 (December 2019): 1089–90. https://doi.org/10.1016/j.jchf.2019.10.006.
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  - Pieske, Burkert, Mahesh J. Patel, Cynthia M. Westerhout, Kevin J. Anstrom, Javed Butler, Justin Ezekowitz, Adrian F. Hernandez, et al. “Baseline features of the VICTORIA (Vericiguat Global Study in Subjects with Heart Failure with Reduced Ejection Fraction) trial.” Eur J Heart Fail 21, no. 12 (December 2019): 1596–1604. https://doi.org/10.1002/ejhf.1664.
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  - Regan, Jessica A., Dalane W. Kitzman, Eric S. Leifer, William E. Kraus, Jerome L. Fleg, Daniel E. Forman, David J. Whellan, et al. “Impact of Age on Comorbidities and Outcomes in Heart Failure With Reduced Ejection Fraction.” Jacc Heart Fail 7, no. 12 (December 2019): 1056–65. https://doi.org/10.1016/j.jchf.2019.09.004.
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  - Beldhuis, Iris E., Koen W. Streng, Peter van der Meer, Jozine M. Ter Maaten, Christopher M. O’Connor, Marco Metra, Howard C. Dittrich, et al. “Trajectories of Changes in Renal Function in Patients with Acute Heart Failure.” J Card Fail 25, no. 11 (November 2019): 866–74. https://doi.org/10.1016/j.cardfail.2019.07.004.
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  - Beusekamp, Joost C., Jasper Tromp, John G. F. Cleland, Michael M. Givertz, Marco Metra, Christopher M. O’Connor, John R. Teerlink, et al. “Hyperkalemia and Treatment With RAAS Inhibitors During Acute Heart Failure Hospitalizations and Their Association With Mortality.” Jacc. Heart Failure 7, no. 11 (November 2019): 970–79. https://doi.org/10.1016/j.jchf.2019.07.010.
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  - Greene, Stephen J., Adam D. DeVore, Shubin Sheng, Gregg C. Fonarow, Javed Butler, Robert M. Califf, Adrian F. Hernandez, et al. “Representativeness of a Heart Failure Trial by Race and Sex: Results From ASCEND-HF and GWTG-HF.” Jacc. Heart Failure 7, no. 11 (November 2019): 980–92. https://doi.org/10.1016/j.jchf.2019.07.011.
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  - O’Connor, Christopher M. “A Call for Change: Level of Statistical Significance.” Jacc. Heart Failure 7, no. 11 (November 2019): 993–94. https://doi.org/10.1016/j.jchf.2019.09.005.
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  - Psotka, Mitchell A., Mona Fiuzat, Peter E. Carson, David P. Kao, Jeffrey Cerkvenik, Daniel E. Schaber, Patrick Verta, et al. “Design of a "Lean" Case Report Form for Heart Failure Therapeutic Development.” Jacc Heart Fail 7, no. 11 (November 2019): 913–21. https://doi.org/10.1016/j.jchf.2019.07.001.
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  - Truesdell, Alexander G., Behnam Tehrani, Carolyn Rosner, Ramesh Singh, Shashank Sinha, Mehul Desai, Shashank Desai, et al. “After Action Reviews.” J Invasive Cardiol 31, no. 11 (November 2019): E341.
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  - O’Connor, Christopher M. “Acute Decompensated Heart Failure: Is There a Path Forward?” Jacc. Heart Failure 7, no. 10 (October 2019): 911–12. https://doi.org/10.1016/j.jchf.2019.08.005.
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  - Januzzi, James L., Tariq Ahmad, Hillary Mulder, Adrian Coles, Kevin J. Anstrom, Kirkwood F. Adams, Justin A. Ezekowitz, et al. “Natriuretic Peptide Response and Outcomes in Chronic Heart Failure With Reduced Ejection Fraction.” J Am Coll Cardiol 74, no. 9 (September 3, 2019): 1205–17. https://doi.org/10.1016/j.jacc.2019.06.055.
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  - Grodin, Justin L., Max J. Liebo, Javed Butler, Marco Metra, G Michael Felker, Adrian F. Hernandez, Adriaan A. Voors, et al. “Prognostic Implications of Changes in Amino-Terminal Pro-B-Type Natriuretic Peptide in Acute Decompensated Heart Failure: Insights From ASCEND-HF.” J Card Fail 25, no. 9 (September 2019): 703–11. https://doi.org/10.1016/j.cardfail.2019.04.002.
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  - O’Connor, Christopher M. “Heart Failure Physician Burnout: How Can We Help?” Jacc Heart Fail 7, no. 9 (September 2019): 821. https://doi.org/10.1016/j.jchf.2019.07.004.
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  - Felker, G Michael, Maria Borentain, John G. Cleland, Mary M. DeSouza, Paul D. Kessler, Christopher M. O’Connor, Dietmar Seiffert, John R. Teerlink, Adriaan A. Voors, and John J. V. McMurray. “Rationale and design for the development of a novel nitroxyl donor in patients with acute heart failure.” Eur J Heart Fail 21, no. 8 (August 2019): 1022–31. https://doi.org/10.1002/ejhf.1504.
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  - O’Connor, Christopher M. “Why Should We Publish All Clinical Trials?” Jacc Heart Fail 7, no. 8 (August 2019): 730. https://doi.org/10.1016/j.jchf.2019.06.009.
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  - Warraich, Haider J., Christopher M. O’Connor, Hongqiu Yang, Bradi B. Granger, Kimberly S. Johnson, Daniel B. Mark, Kevin J. Anstrom, et al. “African Americans With Advanced Heart Failure Are More Likely to Die in a Health Care Facility Than at Home or in Hospice: An Analysis From the PAL-HF Trial.” J Card Fail 25, no. 8 (August 2019): 693–94. https://doi.org/10.1016/j.cardfail.2019.05.013.
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  - Tehrani, Behnam N., and Christopher M. O’Connor. “Reply: Standardized and Tailored Approach to Therapies for Cardiogenic Shock.” J Am Coll Cardiol 74, no. 4 (July 30, 2019): 593–94. https://doi.org/10.1016/j.jacc.2019.05.039.
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  - O’Connor, Christopher M. “N-of-1 Clinical Trials.” Jacc Heart Fail 7, no. 7 (July 2019): 630–31. https://doi.org/10.1016/j.jchf.2019.05.004.
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  - Ambrosy, Andrew P., Robert J. Mentz, Mona Fiuzat, John G. F. Cleland, Stephen J. Greene, Christopher M. O’Connor, John R. Teerlink, Faiez Zannad, and Scott D. Solomon. “Erratum to 'The role of angiotensin receptor-neprilysin inhibitors in cardiovascular disease-existing evidence, knowledge gaps, and future directions' [Eur J Heart Fail 2018;20:963-972].” Eur J Heart Fail 21, no. 6 (June 2019): 819. https://doi.org/10.1002/ejhf.1480.
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  - Blumenthal, James A., Yidan Zhu, Gary G. Koch, Patrick J. Smith, Lana L. Watkins, Alan L. Hinderliter, Benson M. Hoffman, et al. “The modifying effects of social support on psychological outcomes in patients with heart failure.” Health Psychol 38, no. 6 (June 2019): 502–8. https://doi.org/10.1037/hea0000716.
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  - O’Connor, Christopher M. “Better Quality of Life Over More Quantity of Life: How We View Time Trade-Off.” Jacc Heart Fail 7, no. 6 (June 2019): 531–32. https://doi.org/10.1016/j.jchf.2019.05.001.
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  - O’Connor, Christopher, Mona Fiuzat, Hillary Mulder, Adrian Coles, Tariq Ahmad, Justin A. Ezekowitz, Kirkwood F. Adams, et al. “Clinical factors related to morbidity and mortality in high-risk heart failure patients: the GUIDE-IT predictive model and risk score.” Eur J Heart Fail 21, no. 6 (June 2019): 770–78. https://doi.org/10.1002/ejhf.1450.
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  - Butler, Javed, Carolyn S. P. Lam, Kevin J. Anstrom, Justin Ezekowitz, Adrian F. Hernandez, Christopher M. O’Connor, Burkert Pieske, et al. “Rationale and Design of the VITALITY-HFpEF Trial.” Circ Heart Fail 12, no. 5 (May 2019): e005998. https://doi.org/10.1161/CIRCHEARTFAILURE.119.005998.
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  - O’Connor, Christopher M. “Guideline-Directed Medical Therapy Clinics: A Call to Action for the Heart Failure Team.” Jacc Heart Fail 7, no. 5 (May 2019): 442–43. https://doi.org/10.1016/j.jchf.2019.04.001.
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  - Lindenfeld, JoAnn, and Christopher M. O’Connor. “Heart Failure in Women.” Jacc Heart Fail 7, no. 3 (March 2019): 274–75. https://doi.org/10.1016/j.jchf.2019.01.012.
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  - Luo, Nancy, Christopher M. O’Connor, Lauren B. Cooper, Jie-Lena Sun, Adrian Coles, Shelby D. Reed, David J. Whellan, Ileana L. Piña, William E. Kraus, and Robert J. Mentz. “Relationship between changing patient-reported outcomes and subsequent clinical events in patients with chronic heart failure: insights from HF-ACTION.” Eur J Heart Fail 21, no. 1 (January 2019): 63–70. https://doi.org/10.1002/ejhf.1299.
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  - Taylor, Rod S., Sarah Walker, Neil A. Smart, Massimo F. Piepoli, Fiona C. Warren, Oriana Ciani, Christopher O’Connor, et al. “Impact of exercise-based cardiac rehabilitation in patients with heart failure (ExTraMATCH II) on mortality and hospitalisation: an individual patient data meta-analysis of randomised trials.” Eur J Heart Fail 20, no. 12 (December 2018): 1735–43. https://doi.org/10.1002/ejhf.1311.
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  - Mark, Daniel B., Patricia A. Cowper, Kevin J. Anstrom, Shubin Sheng, Melanie R. Daniels, J David Knight, Khaula N. Baloch, et al. “Economic and Quality-of-Life Outcomes of Natriuretic Peptide-Guided Therapy for Heart Failure.” J Am Coll Cardiol 72, no. 21 (November 27, 2018): 2551–62. https://doi.org/10.1016/j.jacc.2018.08.2184.
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  - Fudim, Marat, Christopher M. O’Connor, Hillary Mulder, Adrian Coles, Ankeet S. Bhatt, Andrew P. Ambrosy, William E. Kraus, Ileana L. Piña, David J. Whellan, and Robert J. Mentz. “Loop diuretic adjustments in patients with chronic heart failure: Insights from HF-ACTION.” Am Heart J 205 (November 2018): 133–41. https://doi.org/10.1016/j.ahj.2018.06.017.
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  - Hamo, Carine E., Christopher O’Connor, Marco Metra, James E. Udelson, Mihai Gheorghiade, and Javed Butler. “A Critical Appraisal of Short-Term End Points in Acute Heart Failure Clinical Trials.” J Card Fail 24, no. 11 (November 2018): 783–92. https://doi.org/10.1016/j.cardfail.2018.08.007.
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  - Sharma, Abhinav, Lauren B. Cooper, Mona Fiuzat, Robert J. Mentz, João Pedro Ferreira, Javed Butler, David Fitchett, Alan Charles Moses, Christopher O’Connor, and Faiez Zannad. “Antihyperglycemic Therapies to Treat Patients With Heart Failure and Diabetes Mellitus.” Jacc Heart Fail 6, no. 10 (October 2018): 813–22. https://doi.org/10.1016/j.jchf.2018.05.020.
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  - Tahhan, Ayman Samman, Muthiah Vaduganathan, Stephen J. Greene, Gregg C. Fonarow, Mona Fiuzat, Mariell Jessup, JoAnn Lindenfeld, Christopher M. O’Connor, and Javed Butler. “Enrollment of Older Patients, Women, and Racial and Ethnic Minorities in Contemporary Heart Failure Clinical Trials: A Systematic Review.” Jama Cardiol 3, no. 10 (October 1, 2018): 1011–19. https://doi.org/10.1001/jamacardio.2018.2559.
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  - Greene, Stephen J., Robert J. Mentz, Mona Fiuzat, Javed Butler, Scott D. Solomon, Andrew P. Ambrosy, Cyrus Mehta, John R. Teerlink, Faiez Zannad, and Christopher M. O’Connor. “Reassessing the Role of Surrogate End Points in Drug Development for Heart Failure.” Circulation 138, no. 10 (September 2018): 1039–53. https://doi.org/10.1161/circulationaha.118.034668.
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  - Grodin, Justin L., Javed Butler, Marco Metra, G Michael Felker, Adriaan A. Voors, John J. McMurray, Paul W. Armstrong, et al. “Circulating Cardiac Troponin I Levels Measured by a Novel Highly Sensitive Assay in Acute Decompensated Heart Failure: Insights From the ASCEND-HF Trial.” J Card Fail 24, no. 8 (August 2018): 512–19. https://doi.org/10.1016/j.cardfail.2018.06.008.
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  - O’Connor, Christopher M. “HFpEF: From Early Observations to Worldwide Awareness.” Jacc Heart Fail 6, no. 8 (August 2018): 718–19. https://doi.org/10.1016/j.jchf.2018.07.001.
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  - Parikh, Kishan S., Kavita Sharma, Mona Fiuzat, Howard K. Surks, Jyothis T. George, Narimon Honarpour, Christopher Depre, et al. “Heart Failure With Preserved Ejection Fraction Expert Panel Report: Current Controversies and Implications for Clinical Trials.” Jacc Heart Fail 6, no. 8 (August 2018): 619–32. https://doi.org/10.1016/j.jchf.2018.06.008.
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  - Parikh, Kishan S., Mona Fiuzat, Gordon Davis, Megan Neely, Penny Blain-Nelson, David J. Whellan, William T. Abraham, et al. “Dose Response of β-Blockers in Adrenergic Receptor Polymorphism Genotypes.” Circ Genom Precis Med 11, no. 8 (August 2018): e002210. https://doi.org/10.1161/CIRCGEN.117.002210.
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  - Vaduganathan, Muthiah, Ravi B. Patel, Robert J. Mentz, Haris Subacius, Neal A. Chatterjee, Stephen J. Greene, Andrew P. Ambrosy, et al. “Sudden Death After Hospitalization for Heart Failure With Reduced Ejection Fraction (from the EVEREST Trial).” Am J Cardiol 122, no. 2 (July 15, 2018): 255–60. https://doi.org/10.1016/j.amjcard.2018.03.362.
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  - Daubert, Melissa A., David J. Whellan, Holger Woehrle, Gudaye Tasissa, Kevin J. Anstrom, JoAnn Lindenfeld, Adam Benjafield, et al. “Treatment of sleep-disordered breathing in heart failure impacts cardiac remodeling: Insights from the CAT-HF Trial.” Am Heart J 201 (July 2018): 40–48. https://doi.org/10.1016/j.ahj.2018.03.026.
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  - O’Connor, Christopher M. “Cardiovascular Drug Pricing: Less Innovation for More Access?” Jacc Heart Fail 6, no. 7 (July 2018): 613–14. https://doi.org/10.1016/j.jchf.2018.05.016.
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  - Warraich, Haider J., Christopher O’Connor, Angie Wu, Adrian Coles, William E. Kraus, Ileana L. Piña, David J. Whellan, and Robert J. Mentz. “Differences Between Patients Enrolled Early and Late During Clinical Trial Recruitment: Insights From the HF-ACTION Trial.” Circ Cardiovasc Qual Outcomes 11, no. 7 (July 2018): e004643. https://doi.org/10.1161/CIRCOUTCOMES.117.004643.
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  - Ambrosy, Andrew P., Robert J. Mentz, Mona Fiuzat, John G. F. Cleland, Stephen J. Greene, Christopher M. O’Connor, John R. Teerlink, Faiez Zannad, and Scott D. Solomon. “The role of angiotensin receptor-neprilysin inhibitors in cardiovascular disease-existing evidence, knowledge gaps, and future directions.” European Journal of Heart Failure 20, no. 6 (June 2018): 963–72. https://doi.org/10.1002/ejhf.1159.
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  - Ahmad, Tariq, Keyanna Jackson, Veena S. Rao, WH Wilson Tang, Meredith A. Brisco-Bacik, Horng H. Chen, G Michael Felker, et al. “Worsening Renal Function in Patients With Acute Heart Failure Undergoing Aggressive Diuresis Is Not Associated With Tubular Injury.” Circulation 137, no. 19 (May 2018): 2016–28. https://doi.org/10.1161/circulationaha.117.030112.
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  - Ambrosy, Andrew P., Ankeet S. Bhatt, Amanda L. Stebbins, Lisa M. Wruck, Marat Fudim, Stephen J. Greene, William E. Kraus, et al. “Prevalent digoxin use and subsequent risk of death or hospitalization in ambulatory heart failure patients with a reduced ejection fraction-Findings from the Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) randomized controlled trial.” Am Heart J 199 (May 2018): 97–104. https://doi.org/10.1016/j.ahj.2018.02.004.
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  - Rubio-Gracia, Jorge, Biniyam G. Demissei, Jozine M. Ter Maaten, John G. Cleland, Christopher M. O’Connor, Marco Metra, Piotr Ponikowski, et al. “Prevalence, predictors and clinical outcome of residual congestion in acute decompensated heart failure.” International Journal of Cardiology 258 (May 2018): 185–91. https://doi.org/10.1016/j.ijcard.2018.01.067.
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  - Cerbin, Lukasz P., Andrew P. Ambrosy, Stephen J. Greene, Paul W. Armstrong, Javed Butler, Adrian Coles, Adam D. DeVore, et al. “Is Time of the Essence? The Impact of Time of Hospital Presentation in Acute Heart Failure: Insights From ASCEND-HF Trial.” Jacc Heart Fail 6, no. 4 (April 2018): 298–307. https://doi.org/10.1016/j.jchf.2018.01.018.
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  - O’Connor, Christopher M., and Michael R. Bristow. “Changing the Research Culture in the United States.” Jacc. Heart Failure 6, no. 4 (April 2018): 344–45. https://doi.org/10.1016/j.jchf.2018.03.001.
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  - Bhatt, Ankeet S., Lauren B. Cooper, Andrew P. Ambrosy, Robert M. Clare, Adrian Coles, Emer Joyce, Arun Krishnamoorthy, et al. “Interaction of Body Mass Index on the Association Between N-Terminal-Pro-b-Type Natriuretic Peptide and Morbidity and Mortality in Patients With Acute Heart Failure: Findings From ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure).” J Am Heart Assoc 7, no. 3 (February 3, 2018). https://doi.org/10.1161/JAHA.117.006740.
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  - Armstrong, Paul W., Lothar Roessig, Mahesh J. Patel, Kevin J. Anstrom, Javed Butler, Adriaan A. Voors, Carolyn S. P. Lam, et al. “A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of the Efficacy and Safety of the Oral Soluble Guanylate Cyclase Stimulator: The VICTORIA Trial.” Jacc Heart Fail 6, no. 2 (February 2018): 96–104. https://doi.org/10.1016/j.jchf.2017.08.013.
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  - O’Connor, Christopher M. “Smartphone, Mom, and HFpEF.” Jacc Heart Fail 6, no. 2 (February 2018): 176. https://doi.org/10.1016/j.jchf.2017.12.010.
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  - O’Connor, Christopher M. “I Don't Care How Low My BNP Is, I Want to Feel Good.” Jacc Heart Fail 6, no. 1 (January 2018): 82–83. https://doi.org/10.1016/j.jchf.2017.11.004.
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  - O’Connor, Christopher M., Mitchell A. Psotka, Mona Fiuzat, JoAnn Lindenfeld, William T. Abraham, Michael R. Bristow, Daniel Canos, et al. “Improving Heart Failure Therapeutics Development in the United States: The Heart Failure Collaboratory.” Journal of the American College of Cardiology 71, no. 4 (January 2018): 443–53. https://doi.org/10.1016/j.jacc.2017.11.048.
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  - Pastva, Amy M., Pamela W. Duncan, Gordon R. Reeves, M Benjamin Nelson, David J. Whellan, Christopher M. O’Connor, Joel D. Eggebeen, et al. “Strategies for supporting intervention fidelity in the rehabilitation therapy in older acute heart failure patients (REHAB-HF) trial.” Contemp Clin Trials 64 (January 2018): 118–27. https://doi.org/10.1016/j.cct.2017.10.014.
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  - Daubert, Melissa A., Eric Yow, Gary Dunn, Sotir Marchev, Huiman Barnhart, Pamela S. Douglas, Christopher O’Connor, Sidney Goldstein, James E. Udelson, and Hani N. Sabbah. “Novel Mitochondria-Targeting Peptide in Heart Failure Treatment: A Randomized, Placebo-Controlled Trial of Elamipretide.” Circulation. Heart Failure 10, no. 12 (December 2017). https://doi.org/10.1161/circheartfailure.117.004389.
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  - O’Connor, Christopher M. “Goodbye Mihai: We Will Miss You.” Jacc Heart Fail 5, no. 11 (November 2017): 848–49. https://doi.org/10.1016/j.jchf.2017.09.007.
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  - O’Connor, Christopher M. “Q&A With the JACC: Heart Failure Editor-in-Chief: Marking the 5-Year Milestone.” Jacc Heart Fail 5, no. 10 (October 2017): 758–59. https://doi.org/10.1016/j.jchf.2017.08.006.
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  - Sharma, Abhinav, Susanna R. Stevens, Joseph Lucas, Mona Fiuzat, Kirkwood F. Adams, David J. Whellan, Mark P. Donahue, et al. “Utility of Growth Differentiation Factor-15, A Marker of Oxidative Stress and Inflammation, in Chronic Heart Failure: Insights From the HF-ACTION Study.” Jacc Heart Fail 5, no. 10 (October 2017): 724–34. https://doi.org/10.1016/j.jchf.2017.07.013.
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  - O’Connor, Christopher M. “America and Apple Pie: How Do We Change the American Health Care System?” Jacc Heart Fail 5, no. 9 (September 2017): 686–87. https://doi.org/10.1016/j.jchf.2017.07.006.
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  - Sherwood, Andrew, LaBarron K. Hill, James A. Blumenthal, Kirkwood F. Adams, Nicola J. Paine, Gary G. Koch, Christopher M. O’Connor, Kristy S. Johnson, and Alan L. Hinderliter. “Blood pressure reactivity to psychological stress is associated with clinical outcomes in patients with heart failure.” Am Heart J 191 (September 2017): 82–90. https://doi.org/10.1016/j.ahj.2017.07.003.
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  - O’Connor, Christopher M. “Does Institutional Memory Matter?” Jacc. Heart Failure 5, no. 8 (August 2017): 616. https://doi.org/10.1016/j.jchf.2017.07.001.
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  - O’Connor, Christopher M. “A Decade With Editorial Mentors: The Day They Dropped the Mic.” Jacc Heart Fail 5, no. 7 (July 2017): 541–42. https://doi.org/10.1016/j.jchf.2017.05.009.
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  - Tromp, Jasper, Mohsin A. F. Khan, Robert J. Mentz, Christopher M. O’Connor, Marco Metra, Howard C. Dittrich, Piotr Ponikowski, et al. “Biomarker Profiles of Acute Heart Failure Patients With a Mid-Range Ejection Fraction.” Jacc Heart Fail 5, no. 7 (July 2017): 507–17. https://doi.org/10.1016/j.jchf.2017.04.007.
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  - Ambrosy, Andrew P., Lukasz P. Cerbin, Adam D. DeVore, Stephen J. Greene, William E. Kraus, Christopher M. O’Connor, Ileana L. Piña, et al. “Aerobic exercise training and general health status in ambulatory heart failure patients with a reduced ejection fraction-Findings from the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION)trial.” Am Heart J 186 (April 2017): 130–38. https://doi.org/10.1016/j.ahj.2016.12.017.
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  - Felker, G Michael, Robert J. Mentz, Robert T. Cole, Kirkwood F. Adams, Gregory F. Egnaczyk, Mona Fiuzat, Chetan B. Patel, et al. “Efficacy and Safety of Tolvaptan in Patients Hospitalized With Acute Heart Failure.” Journal of the American College of Cardiology 69, no. 11 (March 2017): 1399–1406. https://doi.org/10.1016/j.jacc.2016.09.004.
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  - Matsue, Yuya, Jozine M. Ter Maaten, Joachim Struck, Marco Metra, Christopher M. O’Connor, Piotr Ponikowski, John R. Teerlink, et al. “Clinical Correlates and Prognostic Value of Proenkephalin in Acute and Chronic Heart Failure.” J Card Fail 23, no. 3 (March 2017): 231–39. https://doi.org/10.1016/j.cardfail.2016.09.007.
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  - Matsue, Yuya, Peter van der Meer, Kevin Damman, Marco Metra, Christopher M. O’Connor, Piotr Ponikowski, John R. Teerlink, et al. “Blood urea nitrogen-to-creatinine ratio in the general population and in patients with acute heart failure.” Heart (British Cardiac Society) 103, no. 6 (March 2017): 407–13. https://doi.org/10.1136/heartjnl-2016-310112.
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  - Feigal, Jacob P., Stephen H. Boyle, Zainab Samad, Eric J. Velazquez, Jennifer L. Wilson, Richard C. Becker, Redford B. Williams, et al. “Associations between positive emotional well-being and stress-induced myocardial ischemia: Well-being scores predict exercise-induced ischemia.” J Psychosom Res 93 (February 2017): 14–18. https://doi.org/10.1016/j.jpsychores.2016.11.012.
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  - Kitai, Takeshi, Justin L. Grodin, Robert J. Mentz, Adrian F. Hernandez, Javed Butler, Marco Metra, John J. McMurray, et al. “Insufficient reduction in heart rate during hospitalization despite beta-blocker treatment in acute decompensated heart failure: insights from the ASCEND-HF trial.” Eur J Heart Fail 19, no. 2 (February 2017): 241–49. https://doi.org/10.1002/ejhf.629.
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  - Tromp, Jasper, Jozine M. Ter Maaten, Kevin Damman, Christopher M. O’Connor, Marco Metra, Howard C. Dittrich, Piotr Ponikowski, et al. “Serum Potassium Levels and Outcome in Acute Heart Failure (Data from the PROTECT and COACH Trials).” Am J Cardiol 119, no. 2 (January 15, 2017): 290–96. https://doi.org/10.1016/j.amjcard.2016.09.038.
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  - Streng, Koen W., Jozine M. Ter Maaten, John G. Cleland, Christopher M. O’Connor, Beth A. Davison, Marco Metra, Michael M. Givertz, et al. “Associations of Body Mass Index With Laboratory and Biomarkers in Patients With Acute Heart Failure.” Circ Heart Fail 10, no. 1 (January 2017). https://doi.org/10.1161/CIRCHEARTFAILURE.116.003350.
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  - Biegus, Jan, Hans L. Hillege, Douwe Postmus, Mattia A. E. Valente, Daniel M. Bloomfield, John G. F. Cleland, Gad Cotter, et al. “Abnormal liver function tests in acute heart failure: relationship with clinical characteristics and outcome in the PROTECT study.” Eur J Heart Fail 18, no. 7 (July 2016): 830–39. https://doi.org/10.1002/ejhf.532.
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  - Denardo, Scott J., David M. Vock, Carsten M. Schmalfuss, Gregory D. Young, James E. Tcheng, and Christopher M. O’Connor. “Baseline Hemodynamics and Response to Contrast Media During Diagnostic Cardiac Catheterization Predict Adverse Events in Heart Failure Patients.” Circ Heart Fail 9, no. 7 (July 2016). https://doi.org/10.1161/CIRCHEARTFAILURE.115.002529.
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  - Emmens, Johanna E., Jozine M. Ter Maaten, Yuya Matsue, Marco Metra, Christopher M. O’Connor, Piotr Ponikowski, John R. Teerlink, et al. “Plasma kidney injury molecule-1 in heart failure: renal mechanisms and clinical outcome.” Eur J Heart Fail 18, no. 6 (June 2016): 641–49. https://doi.org/10.1002/ejhf.426.
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  - Ter Maaten, Jozine M., Mattia A. E. Valente, Kevin Damman, John G. Cleland, Michael M. Givertz, Marco Metra, Christopher M. O’Connor, et al. “Combining Diuretic Response and Hemoconcentration to Predict Rehospitalization After Admission for Acute Heart Failure.” Circ Heart Fail 9, no. 6 (June 2016). https://doi.org/10.1161/CIRCHEARTFAILURE.115.002845.
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  - Whellan, David J., Amanda Stebbins, Adrian F. Hernandez, Justin A. Ezekowitz, John J. V. McMurray, Paul J. Mather, Vic Hasselblad, and Christopher M. O’Connor. “Dichotomous Relationship Between Age and 30-Day Death or Rehospitalization in Heart Failure Patients Admitted With Acute Decompensated Heart Failure: Results From the ASCEND-HF Trial.” J Card Fail 22, no. 6 (June 2016): 409–16. https://doi.org/10.1016/j.cardfail.2016.02.011.
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  - Navarese, Eliano P., Michalina Kolodziejczak, Dean J. Kereiakes, Udaya S. Tantry, Christopher O’Connor, and Paul A. Gurbel. “Proprotein Convertase Subtilisin/Kexin Type 9 Monoclonal Antibodies for Acute Coronary Syndrome: A Narrative Review.” Ann Intern Med 164, no. 9 (May 3, 2016): 600–607. https://doi.org/10.7326/M15-2994.
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  - Gheorghiade, Mihai, Wendy A. Gattis, Alejandro Barbagelata, Kirkwood F. Adams, Uri Elkayam, Cesare Orlandi, Christopher M. O’Connor, and Christopher M. Acute and Chronic Therapeutic Impact of a Vasopressin Antagonist in Congestive Heart Failure Investigators. “Rationale and study design for a multicenter, randomized, double-blind, placebo-controlled study of the effects of tolvaptan on the acute and chronic outcomes of patients hospitalized with worsening congestive heart failure.” Am Heart J 145, no. 2 Suppl (February 2003): S51–54. https://doi.org/10.1067/mhj.2003.154.
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  - Gattis, Wendy A., Christopher M. O’Connor, Jeffrey D. Leimberger, G Michael Felker, Kirkwood F. Adams, and Mihai Gheorghiade. “Clinical outcomes in patients on beta-blocker therapy admitted with worsening chronic heart failure.” Am J Cardiol 91, no. 2 (January 15, 2003): 169–74. https://doi.org/10.1016/s0002-9149(02)03104-1.
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  - Carson, P. A., C. M. O’Connor, A. B. Miller, S. Anderson, R. Belkin, G. W. Neuberg, J. H. Wertheimer, D. Frid, A. Cropp, and M. Packer. “Circadian rhythm and sudden death in heart failure: results from Prospective Randomized Amlodipine Survival Trial.” J Am Coll Cardiol 36, no. 2 (August 2000): 541–46. https://doi.org/10.1016/s0735-1097(00)00728-2.
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  - Davis, C. J., P. A. Gurbel, W. A. Gattis, S. Y. Fuzaylov, G. V. Nair, C. M. O’Connor, and V. L. Serebruany. “Hemostatic abnormalities in patients with congestive heart failure: diagnostic significance and clinical challenge.” Int J Cardiol 75, no. 1 (August 2000): 15–21. https://doi.org/10.1016/s0167-5273(00)00300-4.
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  - Kong, D. F., M. A. Blazing, and C. M. O’Connor. “Advances in the approach to acute coronary syndromes.” Hosp Pract (1995) 35, no. 4 (April 15, 2000): 61–64. https://doi.org/10.3810/hp.2000.04.192.
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  - O’Connor, C. M., W. A. Gattis, and T. J. Ryan. “The role of clinical nonfatal end points in cardiovascular phase II/III clinical trials.” Am Heart J 139, no. 4 (April 2000): S143–54. https://doi.org/10.1016/s0002-8703(00)90062-0.
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  - Serebruany, V. L., D. R. Lowry, S. Y. Fuzailov, D. J. Levine, C. M. O’Connor, and P. A. Gurbel. “Moderate alcohol consumption is associated with decreased platelet activity in patients presenting with acute myocardial infarction.” J Thromb Thrombolysis 9, no. 3 (April 2000): 229–34. https://doi.org/10.1023/a:1018762510842.
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  - Califf, R. M., and C. M. O’Connor. “Beta-blocker therapy for heart failure: the evidence is in, now the work begins.” Jama 283, no. 10 (March 8, 2000): 1335–37. https://doi.org/10.1001/jama.283.10.1335.
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  - Shah, A., G. S. Wagner, C. B. Granger, C. M. O’Connor, C. L. Green, K. M. Trollinger, R. M. Califf, and M. W. Krucoff. “Prognostic implications of TIMI flow grade in the infarct related artery compared with continuous 12-lead ST-segment resolution analysis. Reexamining the "gold standard" for myocardial reperfusion assessment.” J Am Coll Cardiol 35, no. 3 (March 1, 2000): 666–72. https://doi.org/10.1016/s0735-1097(99)00601-4.
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  - Gurbel, P. A., D. J. Kereiakes, M. R. Dalesandro, R. D. Bahr, C. M. O’Connor, and V. L. Serebruany. “Role of soluble and platelet-bound P-selectin in discriminating cardiac from noncardiac chest pain at presentation in the emergency department.” Am Heart J 139, no. 2 Pt 1 (February 2000): 320–28. https://doi.org/10.1067/mhj.2000.101109.
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  - Bosworth, H. B., D. C. Steffens, M. N. Kuchibhatla, W. J. Jiang, R. M. Arias, C. M. O’Connor, and K. R. R. Krishnan. “The relationship of social support, social networks and negative events with depression in patients with coronary artery disease.” Aging and Mental Health 4, no. 3 (January 1, 2000): 253–58. https://doi.org/10.1080/713649927.
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  - Cuffe, M. S., R. M. Califf, K. F. Adams, R. C. Bourge, W. Colucci, B. Massie, C. M. O’Connor, et al. “Rationale and design of the OPTIME CHF trial: outcomes of a prospective trial of intravenous milrinone for exacerbations of chronic heart failure.” Am Heart J 139, no. 1 Pt 1 (January 2000): 15–22. https://doi.org/10.1016/s0002-8703(00)90303-x.
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  - Gattis, W., and C. M. O’Connor. “[Calcium antagonists in the treatment of heart failure. Re-evaluation of therapeutic strategies].” Drugs 59 Spec No 2 (2000): 17–24.
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  - Gattis, W., and C. M. O’Connor. “Calcium antagonist use in heart failure: A re-evalutaion of treatment options.” Drugs 59, no. SPEC. ISS. 2 (January 1, 2000): 17–24. https://doi.org/10.2165/00003495-200059992-00003.
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  - Gurbel, P. A., D. J. Kereiakes, M. R. Dalesandro, R. D. Bahr, C. M. O’Connor, and V. L. Serebruany. “Role of soluble and platelet-bound P-selectin in discriminating cardiac from noncardiac chest pain at presentation in the emergency department.” American Heart Journal 139, no. 2 I (2000): 320–28.
  - Fortner, Molly R., Kristine Brown, Indu M. Varia, Kenneth R. Gersing, Christopher O’Connor, and P Murali Doraiswamy. “Effect of Bupropion SR on the Quality of Life of Elderly Depressed Patients With Comorbid Medical Disorders.” Prim Care Companion J Clin Psychiatry 1, no. 6 (December 1999): 174–79. https://doi.org/10.4088/pcc.v01n0601.
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  - O’Connor, C. M., W. A. Gattis, M. Gheorghiade, C. B. Granger, J. Gilbert, J. M. McKenney, F. C. Messineo, et al. “A randomized trial of ecadotril versus placebo in patients with mild to moderate heart failure: the U.S. ecadotril pilot safety study.” Am Heart J 138, no. 6 Pt 1 (December 1999): 1140–48. https://doi.org/10.1016/s0002-8703(99)70081-5.
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  - Velazquez, E. J., and C. M. O’Connor. “Heart failure after myocardial infarction: A good heart is hard to find.” Am Heart J 138, no. 6 Pt 1 (December 1999): 1009–11. https://doi.org/10.1016/s0002-8703(99)70061-x.
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  - Orloff, D. G., M. A. Blazing, and C. M. O’Connor. “Atherosclerotic disease in non-insulin-dependent diabetes mellitus: role of abnormal lipids and the place for lipid-altering therapies.” Am Heart J 138, no. 5 Pt 1 (November 1999): S406–12. https://doi.org/10.1016/s0002-8703(99)70043-8.
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  - Del Carlo, C. H., and C. M. O’Connor. “Cardiac troponins in congestive heart failure.” Am Heart J 138, no. 4 Pt 1 (October 1999): 646–53. https://doi.org/10.1016/s0002-8703(99)70178-x.
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  - Doraiswamy, P. M., J. MacFall, K. R. Krishnan, C. O’Connor, X. Wan, M. Benaur, M. Lewandowski, and M. Fortner. “Magnetic resonance assessment of cerebral perfusion in depressed cardiac patients: preliminary findings.” Am J Psychiatry 156, no. 10 (October 1999): 1641–43. https://doi.org/10.1176/ajp.156.10.1641.
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  - Langer, A., M. Fisher, R. M. Califf, S. Goodman, C. M. O’Connor, R. A. Harrington, and V. Fuster. “Higher rates of coronary angiography and revascularization following myocardial infarction may be associated with greater survival in the United States than in Canada. The CARS Investigators (Coumadin/Aspirin Reinfarction Study).” Can J Cardiol 15, no. 10 (October 1999): 1095–1102.
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  - Langer, A., M. Fisher, R. M. Califf, S. Goodman, C. M. O’Connor, R. A. Harrington, and V. Fuster. “Higher rates of coronary angiography and revascularization following myocardial infarction may be associated with greater survival in the United States than in Canada.” Canadian Journal of Cardiology 15, no. 10 (October 1, 1999): 1095–1102.
  - Gattis, W. A., V. Hasselblad, D. J. Whellan, and C. M. O’Connor. “Reduction in heart failure events by the addition of a clinical pharmacist to the heart failure management team: results of the Pharmacist in Heart Failure Assessment Recommendation and Monitoring (PHARM) Study.” Arch Intern Med 159, no. 16 (September 13, 1999): 1939–45. https://doi.org/10.1001/archinte.159.16.1939.
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  - Gurbel, P. A., C. M. O’Connor, C. C. Cummings, and V. L. Serebruany. “Clopidogrel: the future choice for preventing platelet activation during coronary stenting?” Pharmacol Res 40, no. 2 (August 1999): 107–11. https://doi.org/10.1006/phrs.1999.0478.
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  - Nair, G. V., P. A. Gurbel, C. M. O’Connor, W. A. Gattis, S. R. Murugesan, and V. L. Serebruany. “Depression, coronary events, platelet inhibition, and serotonin reuptake inhibitors.” Am J Cardiol 84, no. 3 (August 1, 1999): 321-A8. https://doi.org/10.1016/s0002-9149(99)00284-2.
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  - Serebruany, V. L., S. R. Murugesan, A. Pothula, D. Atar, D. R. Lowry, C. M. O’Connor, and P. A. Gurbel. “Increased soluble platelet/endothelial cellular adhesion molecule-1 and osteonectin levels in patients with severe congestive heart failure. Independence of disease etiology, and antecedent aspirin therapy.” Eur J Heart Fail 1, no. 3 (August 1999): 243–49. https://doi.org/10.1016/s1388-9842(99)00029-x.
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  - Blazing, M. A., and C. M. O’Connor. “Evidence supporting secondary prevention strategies.” Curr Opin Cardiol 14, no. 4 (July 1999): 303–9. https://doi.org/10.1097/00001573-199907000-00005.
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  - O’Connor, C. M., P. W. Radensky, A. N. Unger, and B. C. Martin. “Hospital use and costs among patients with nonischemic cardiomyopathy in the first prospective randomized amlodipine survival evaluation study.” Clin Ther 21, no. 7 (July 1999): 1254–65. https://doi.org/10.1016/S0149-2918(00)80027-2.
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  - O’Connor, C. M., W. A. Gattis, B. F. Uretsky, K. F. Adams, S. E. McNulty, S. H. Grossman, W. J. McKenna, et al. “Continuous intravenous dobutamine is associated with an increased risk of death in patients with advanced heart failure: insights from the Flolan International Randomized Survival Trial (FIRST).” Am Heart J 138, no. 1 Pt 1 (July 1999): 78–86. https://doi.org/10.1016/s0002-8703(99)70250-4.
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  - O’Connor, C. M., W. A. Gattis, and K. Swedberg. “Current and novel pharmacologic approaches in advanced heart failure.” Heart Lung 28, no. 4 (July 1999): 227–42. https://doi.org/10.1016/s0147-9563(99)70069-5.
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  - Shapiro, P. A., F. Lespérance, N. Frasure-Smith, C. M. O’Connor, B. Baker, J. W. Jiang, P. Dorian, W. Harrison, and A. H. Glassman. “An open-label preliminary trial of sertraline for treatment of major depression after acute myocardial infarction (the SADHAT Trial). Sertraline Anti-Depressant Heart Attack Trial.” Am Heart J 137, no. 6 (June 1999): 1100–1106. https://doi.org/10.1016/s0002-8703(99)70369-8.
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  - Kong, D. F., M. A. Blazing, and C. M. O’Connor. “The health care burden of unstable angina.” Cardiol Clin 17, no. 2 (May 1999): 247–61. https://doi.org/10.1016/s0733-8651(05)70072-2.
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  - O’Connor, C. M., P. A. Gurbel, and V. L. Serebruany. “Usefulness of soluble and surface-bound P-selectin in detecting heightened platelet activity in patients with congestive heart failure.” Am J Cardiol 83, no. 9 (May 1, 1999): 1345–49. https://doi.org/10.1016/s0002-9149(99)00098-3.
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  - Adams, K. F., C. A. Sueta, M. Gheorghiade, C. M. O’Connor, T. A. Schwartz, G. G. Koch, B. Uretsky, et al. “Gender differences in survival in advanced heart failure. Insights from the FIRST study.” Circulation 99, no. 14 (April 13, 1999): 1816–21. https://doi.org/10.1161/01.cir.99.14.1816.
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  - Whellan, D. J., W. A. Gattis, L. Gaulden, B. Granger, and C. M. O’Connor. “Disease management of congestive heart failure.” Am J Manag Care 5, no. 4 (April 1999): 499–507.
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  - O’Connor, C. M., W. A. Gattis, F. Zannad, S. E. McNulty, M. Gheorghiade, K. F. Adams, R. M. Califf, W. J. McKenna, J. Soler-Soler, and K. Swedberg. “Beta-blocker therapy in advanced heart failure: clinical characteristics and long-term outcomes.” Eur J Heart Fail 1, no. 1 (March 1999): 81–88. https://doi.org/10.1016/S1388-9842(98)00004-X.
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  - Steffens, D. C., C. M. O’Connor, W. J. Jiang, C. F. Pieper, M. N. Kuchibhatla, R. M. Arias, A. Look, C. Davenport, M. B. Gonzalez, and K. R. Krishnan. “The effect of major depression on functional status in patients with coronary artery disease.” J Am Geriatr Soc 47, no. 3 (March 1999): 319–22. https://doi.org/10.1111/j.1532-5415.1999.tb02995.x.
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  - Bart, B. A., and C. M. O’Connor. “Clinical determinants of mortality in patients with cardiomyopathy.” Cardiology Review 16, no. 7 (January 1, 1999): 8–11.
  - McKenzie, M. E., A. Pothula, P. A. Gurbel, S. Y. Fuzaylov, C. M. O’Connor, W. A. Gattis, and V. L. Serebruany. “Failure of thrombin generation markers to triage patients presenting with chest pain.” Cardiology 92, no. 1 (1999): 53–58. https://doi.org/10.1159/000006946.
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  - Thel, M. C., and C. M. O’Connor. “Cardiopulmonary resuscitation: historical perspective to recent investigations.” Am Heart J 137, no. 1 (January 1999): 39–48. https://doi.org/10.1016/s0002-8703(99)70458-8.
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  - O’Connor, C. M., P. E. Carson, A. B. Miller, M. L. Pressler, R. N. Belkin, G. W. Neuberg, D. J. Frid, et al. “Effect of amlodipine on mode of death among patients with advanced heart failure in the PRAISE trial. Prospective Randomized Amlodipine Survival Evaluation.” Am J Cardiol 82, no. 7 (October 1, 1998): 881–87. https://doi.org/10.1016/s0002-9149(98)00496-2.
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  - Guyton, J. R., A. C. Goldberg, R. A. Kreisberg, D. L. Sprecher, H. R. Superko, and C. M. O’Connor. “Effectiveness of once-nightly dosing of extended-release niacin alone and in combination for hypercholesterolemia.” Am J Cardiol 82, no. 6 (September 15, 1998): 737–43. https://doi.org/10.1016/s0002-9149(98)00448-2.
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  - Krishnan, K. R., L. K. George, C. F. Pieper, W. Jiang, R. Arias, A. Look, and C. O’Connor. “Depression and social support in elderly patients with cardiac disease.” Am Heart J 136, no. 3 (September 1998): 491–95. https://doi.org/10.1016/s0002-8703(98)70225-x.
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  - Shah, B. R., C. Lin, C. Maynard, B. Bart, R. H. Selvester, L. K. Shaw, C. O’Connor, and G. S. Wagner. “Specificity of electrocardiographic myocardial infarction screening criteria in patients with nonischemic cardiomyopathies.” Am Heart J 136, no. 2 (August 1998): 314–19. https://doi.org/10.1053/hj.1998.v136.89909.
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  - Gattis, W. A., R. L. Larsen, V. Hasselblad, B. A. Bart, and C. M. O’Connor. “Is optimal angiotensin-converting enzyme inhibitor dosing neglected in elderly patients with heart failure?” Am Heart J 136, no. 1 (July 1998): 43–48. https://doi.org/10.1016/s0002-8703(98)70180-2.
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  - Serebruany, V. L., R. D. Bahr, C. M. O’Connor, D. R. Lowry, and P. A. Gurbel. “Antecedent aspirin therapy inhibits baseline platelet activity in patients presenting with acute myocardial infarction. The GUSTO-III Platelet Substudy.” Cardiology 90, no. 1 (July 1998): 37–42. https://doi.org/10.1159/000006814.
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  - O’Connor, C. M., W. A. Gattis, and K. Swedberg. “Current and novel pharmacologic approaches in advanced heart failure.” Am Heart J 135, no. 6 Pt 2 Su (June 1998): S249–63. https://doi.org/10.1016/s0002-8703(98)70254-6.
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  - Serebruany, V. L., D. Atar, M. R. Dalesandro, C. M. O’Connor, and P. A. Gurbel. “Changes in hemostasis after parenteral magnesium in myocardial ischemia-reperfusion: from animal studies to clinical trials.” Magnes Res 11, no. 2 (June 1998): 133–40.
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  - Flack, J. M., C. M. O’Connor, and J. Y. Wei. “Four commonly seen cardiovascular diseases.” Patient Care 32, no. 9 (May 15, 1998): 98–130.
  - Hassan, T. B., and D. B. Barnett. “Magnesium in in-hospital cardiac arrest.” Lancet 351, no. 9100 (February 7, 1998): 445–46. https://doi.org/10.1016/S0140-6736(05)78390-2.
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  - Cuffe, M. S., and C. M. O’Connor. “Pharmacologic management of acute heart failure.” Current Opinion in Critical Care 3, no. 5 (December 1, 1997): 386–90.
  - Blumenthal, J. A., C. O’Connor, A. Hinderliter, K. Fath, S. B. Hegde, G. Miller, J. Puma, et al. “Psychosocial factors and coronary disease. A national multicenter clinical trial (ENRICHD) with a North Carolina focus.” N C Med J 58, no. 6 (November 1997): 440–44.
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  - Thel, M. C., A. L. Armstrong, S. E. McNulty, R. M. Califf, and C. M. O’Connor. “Randomised trial of magnesium in in-hospital cardiac arrest. Duke Internal Medicine Housestaff.” Lancet 350, no. 9087 (November 1, 1997): 1272–76. https://doi.org/10.1016/s0140-6736(97)05048-4.
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  - Blumenthal, J. A., W. Jiang, M. A. Babyak, D. S. Krantz, D. J. Frid, R. E. Coleman, R. Waugh, et al. “Stress management and exercise training in cardiac patients with myocardial ischemia. Effects on prognosis and evaluation of mechanisms.” Arch Intern Med 157, no. 19 (October 27, 1997): 2213–23.
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  - Bart, B. A., L. K. Shaw, C. B. McCants, D. F. Fortin, K. L. Lee, R. M. Califf, and C. M. O’Connor. “Clinical determinants of mortality in patients with angiographically diagnosed ischemic or nonischemic cardiomyopathy.” J Am Coll Cardiol 30, no. 4 (October 1997): 1002–8. https://doi.org/10.1016/s0735-1097(97)00235-0.
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  - Jiang, W., W. R. Hathaway, S. McNulty, R. L. Larsen, K. L. Hansley, Y. Zhang, and C. M. O’Connor. “Ability of heart rate variability to predict prognosis in patients with advanced congestive heart failure.” Am J Cardiol 80, no. 6 (September 15, 1997): 808–11. https://doi.org/10.1016/s0002-9149(97)00526-2.
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  - Hayano, J., W. Jiang, R. Waugh, C. O’Connor, D. Frid, and J. A. Blumenthal. “Stability over time of circadian rhythm of variability of heart rate in patients with stable coronary artery disease.” Am Heart J 134, no. 3 (September 1997): 411–18. https://doi.org/10.1016/s0002-8703(97)70075-9.
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  - O’Connor, C. M., W. R. Hathaway, E. R. Bates, J. D. Leimberger, K. N. Sigmon, D. J. Kereiakes, B. S. George, et al. “Clinical characteristics and long-term outcome of patients in whom congestive heart failure develops after thrombolytic therapy for acute myocardial infarction: development of a predictive model.” Am Heart J 133, no. 6 (June 1997): 663–73. https://doi.org/10.1016/s0002-8703(97)70168-6.
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  - Gullette, E. C., J. A. Blumenthal, M. Babyak, W. Jiang, R. A. Waugh, D. J. Frid, C. M. O’Connor, J. J. Morris, and D. S. Krantz. “Effects of mental stress on myocardial ischemia during daily life.” Jama 277, no. 19 (May 21, 1997): 1521–26.
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  - Bart, B. A., W. A. Gattis, S. J. Diem, and C. M. O’Connor. “Reasons for underuse of angiotensin-converting enzyme inhibitors in patients with heart failure and left ventricular dysfunction.” Am J Cardiol 79, no. 8 (April 15, 1997): 1118–20. https://doi.org/10.1016/s0002-9149(97)00060-x.
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  - Allan, J. J. “Amlodipine in chronic heart failure.” N Engl J Med 336, no. 14 (April 3, 1997): 1023–24.
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  - Packer, M., C. M. O’Connor, J. K. Ghali, M. L. Pressler, P. E. Carson, R. N. Belkin, A. B. Miller, et al. “Effect of amlodipine on morbidity and mortality in severe chronic heart failure. Prospective Randomized Amlodipine Survival Evaluation Study Group.” N Engl J Med 335, no. 15 (October 10, 1996): 1107–14. https://doi.org/10.1056/NEJM199610103351504.
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  - Barefoot, J. C., M. J. Helms, D. B. Mark, J. A. Blumenthal, R. M. Califf, T. L. Haney, C. M. O’Connor, I. C. Siegler, and R. B. Williams. “Depression and long-term mortality risk in patients with coronary artery disease.” Am J Cardiol 78, no. 6 (September 15, 1996): 613–17. https://doi.org/10.1016/s0002-9149(96)00380-3.
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  - Jiang, W., M. Babyak, D. S. Krantz, R. A. Waugh, R. E. Coleman, M. M. Hanson, D. J. Frid, et al. “Mental stress--induced myocardial ischemia and cardiac events.” Jama 275, no. 21 (June 5, 1996): 1651–56. https://doi.org/10.1001/jama.275.21.1651.
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  - O’Connor, C. M., R. B. Meese, S. McNulty, K. D. Lucas, R. J. Carney, R. M. LeBoeuf, W. Maddox, et al. “A randomized factorial trial of reperfusion strategies and aspirin dosing in acute myocardial infarction. The DUCCS-II Investigators.” Am J Cardiol 77, no. 10 (April 15, 1996): 791–97. https://doi.org/10.1016/s0002-9149(97)89171-0.
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  - Mahaffey, K. W., C. B. Granger, R. Collins, C. M. O’Connor, E. M. Ohman, S. D. Bleich, J. J. Col, and R. M. Califf. “Overview of randomized trials of intravenous heparin in patients with acute myocardial infarction treated with thrombolytic therapy.” Am J Cardiol 77, no. 8 (March 15, 1996): 551–56. https://doi.org/10.1016/s0002-9149(97)89305-8.
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  - Gonzalez, M. B., T. B. Snyderman, J. T. Colket, R. M. Arias, J. W. Jiang, C. M. O’Connor, and K. R. Krishnan. “Depression in patients with coronary artery disease.” Depression 4, no. 2 (1996): 57–62. https://doi.org/10.1002/(SICI)1522-7162(1996)4:2<57::AID-DEPR3>3.0.CO;2-C.
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  - Jiang, W., M. A. Trauner, R. E. Coleman, R. A. Waugh, M. W. Hanson, D. J. Frid, B. G. Phillips, J. J. Morris, C. O’Connor, and J. A. Blumenthal. “Association of physical fitness and transient myocardial ischemia in patients with coronary artery disease.” J Cardiopulm Rehabil 15, no. 6 (November 1995): 431–38. https://doi.org/10.1097/00008483-199511000-00007.
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  - Blumenthal, J. A., W. Jiang, R. A. Waugh, D. J. Frid, J. J. Morris, R. E. Coleman, M. Hanson, M. Babyak, E. T. Thyrum, and D. S. Krantz. “Mental stress-induced ischemia in the laboratory and ambulatory ischemia during daily life. Association and hemodynamic features.” Circulation 92, no. 8 (October 15, 1995): 2102–8. https://doi.org/10.1161/01.cir.92.8.2102.
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  - Thel, M. C., and C. M. O’Connor. “Magnesium in acute myocardial infarction.” Coron Artery Dis 6, no. 10 (October 1995): 831–37. https://doi.org/10.1097/00019501-199510000-00012.
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  - Jiang, W., J. A. Blumenthal, M. W. Hanson, R. E. Coleman, C. M. O’Connor, D. Frid, J. J. Morris, and R. A. Waugh. “Relative importance of electrode placement over number of channels in transient myocardial ischemia detection by Holter monitoring.” Am J Cardiol 76, no. 5 (August 15, 1995): 350–54. https://doi.org/10.1016/s0002-9149(99)80099-x.
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  - Mörike, K., and G. Mikus. “Zofenopril after anterior myocardial infarction.” N Engl J Med 332, no. 25 (June 22, 1995): 1715.
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  - Campbell, P. T., J. S. Li, T. C. Wall, C. M. O’Connor, P. Van Trigt, R. T. Kenney, O. Melhus, and G. R. Corey. “Cytomegalovirus pericarditis: a case series and review of the literature.” Am J Med Sci 309, no. 4 (April 1995): 229–34. https://doi.org/10.1097/00000441-199504000-00009.
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  - Selker, H. P., J. R. Beshansky, C. H. Schmid, J. L. Griffith, W. T. Longstreth, C. M. O’Connor, L. R. Caplan, E. W. Massey, R. B. D’Agostino, and M. M. Laks. “Presenting pulse pressure predicts thrombolytic therapy-related intracranial hemorrhage. Thrombolytic Predictive Instrument (TPI) Project results.” Circulation 90, no. 4 (October 1994): 1657–61. https://doi.org/10.1161/01.cir.90.4.1657.
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  - Larsen, R. L., V. S. Behar, S. R. Brazer, J. Chen, and C. M. O’Connor. “Chest pain presenting as ischemic heart disease. Congenital absence of the pericardium.” N C Med J 55, no. 7 (July 1994): 306–8.
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  - O’Connor, C. M., R. Meese, R. Carney, J. Smith, E. Conn, J. Burks, C. Hartman, S. Roark, N. Shadoff, and M. Heard. “A randomized trial of intravenous heparin in conjunction with anistreplase (anisoylated plasminogen streptokinase activator complex) in acute myocardial infarction: the Duke University Clinical Cardiology Study (DUCCS) 1.” J Am Coll Cardiol 23, no. 1 (January 1994): 11–18. https://doi.org/10.1016/0735-1097(94)90496-0.
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  - Van Trigt, P., J. Douglas, P. K. Smith, P. T. Campbell, T. C. Wall, R. T. Kenney, C. M. O’Connor, K. H. Sheikh, and G. R. Corey. “A prospective trial of subxiphoid pericardiotomy in the diagnosis and treatment of large pericardial effusion. A follow-up report.” Ann Surg 218, no. 6 (December 1993): 777–82. https://doi.org/10.1097/00000658-199312000-00012.
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  - Jiang, W., J. Hayano, E. R. Coleman, M. W. Hanson, D. J. Frid, C. O’Connor, D. Thurber, R. A. Waugh, and J. A. Blumenthal. “Relation of cardiovascular responses to mental stress and cardiac vagal activity in coronary artery disease.” Am J Cardiol 72, no. 7 (September 1, 1993): 551–54. https://doi.org/10.1016/0002-9149(93)90350-l.
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  - Corey, G. R., P. T. Campbell, P. Van Trigt, R. T. Kenney, C. M. O’Connor, K. H. Sheikh, J. A. Kisslo, and T. C. Wall. “Etiology of large pericardial effusions.” Am J Med 95, no. 2 (August 1993): 209–13. https://doi.org/10.1016/0002-9343(93)90262-n.
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  - Kenney, R. T., J. S. Li, W. A. Clyde, T. C. Wall, C. M. O’Connor, P. T. Campbell, P. Van Trigt, and G. R. Corey. “Mycoplasmal pericarditis: evidence of invasive disease.” Clin Infect Dis 17 Suppl 1 (August 1993): S58–62. https://doi.org/10.1093/clinids/17.supplement_1.s58.
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  - Krucoff, M. W., M. A. Croll, J. E. Pope, C. B. Granger, C. M. O’Connor, K. N. Sigmon, B. L. Wagner, J. A. Ryan, K. L. Lee, and D. J. Kereiakes. “Continuous 12-lead ST-segment recovery analysis in the TAMI 7 study. Performance of a noninvasive method for real-time detection of failed myocardial reperfusion.” Circulation 88, no. 2 (August 1993): 437–46. https://doi.org/10.1161/01.cir.88.2.437.
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  - Slaughter, T. F., E. A. Mody, H. N. Oldham, J. G. Reves, C. M. O’Connor, J. K. Parker, and C. S. Greenberg. “Management of a patient with type IIC von Willebrand's disease during coronary artery bypass graft surgery.” Anesthesiology 78, no. 1 (January 1993): 195–97. https://doi.org/10.1097/00000542-199301000-00027.
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  - Wall, T. C., P. T. Campbell, C. M. O’Connor, P. Van Trigt, R. T. Kenney, K. H. Sheikh, J. A. Kisslo, and G. R. Corey. “Diagnosis and management (by subxiphoid pericardiotomy) of large pericardial effusions causing cardiac tamponade.” Am J Cardiol 69, no. 12 (April 15, 1992): 1075–78. https://doi.org/10.1016/0002-9149(92)90866-w.
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  - Campbell, P. T., P. Van Trigt, T. C. Wall, R. T. Kenney, C. M. O’Connor, K. H. Sheikh, J. A. Kisslo, M. E. Baker, and G. R. Corey. “Subxiphoid pericardiotomy in the diagnosis and management of large pericardial effusions associated with malignancy.” Chest 101, no. 4 (April 1992): 938–43. https://doi.org/10.1378/chest.101.4.938.
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  - Ortel, T. L., J. P. Gockerman, R. M. Califf, R. L. McCann, C. M. O’Connor, D. M. Metzler, and C. S. Greenberg. “Parenteral anticoagulation with the heparinoid Lomoparan (Org 10172) in patients with heparin induced thrombocytopenia and thrombosis.” Thromb Haemost 67, no. 3 (March 2, 1992): 292–96.
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  - O’Connor, C. M., and R. M. Califf. “Aggressive therapy of acute MI in the elderly.” Hosp Pract (Off Ed) 27, no. 2 (February 15, 1992): 59-passim. https://doi.org/10.1080/21548331.1992.11705360.
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  - Uglietta, J. P., C. M. O’Connor, O. B. Boyko, H. Aldrich, E. W. Massey, and E. R. Heinz. “CT patterns of intracranial hemorrhage complicating thrombolytic therapy for acute myocardial infarction.” Radiology 181, no. 2 (November 1991): 555–59. https://doi.org/10.1148/radiology.181.2.1924804.
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  - Wallis, D. E., W. E. Boden, R. Califf, M. H. Crawford, A. H. Hakki, A. S. Iskandrian, A. Labovitz, C. O’Connor, R. Sutton, and P. J. Scanlon. “Failure of adjuvant heparin to reduce myocardial ischemia in the early treatment of patients with unstable angina.” Am Heart J 122, no. 4 Pt 1 (October 1991): 949–54. https://doi.org/10.1016/0002-8703(91)90456-r.
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  - O’Connor, C. M., R. M. Califf, E. W. Massey, D. B. Mark, D. J. Kereiakes, R. J. Candela, C. Abbottsmith, B. George, R. S. Stack, and L. Aronson. “Stroke and acute myocardial infarction in the thrombolytic era: clinical correlates and long-term prognosis.” J Am Coll Cardiol 16, no. 3 (September 1990): 533–40. https://doi.org/10.1016/0735-1097(90)90338-p.
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  - Blumenthal, J. A., and C. O’Connor. “Stress and silent myocardial ischemia. A new research study at Duke University Medical Center.” N C Med J 51, no. 4 (April 1990): 135–38.
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  - Mark, D. B., M. A. Hlatky, C. M. O’Connor, D. B. Pryor, T. C. Wall, M. B. Honan, H. R. Phillips, and R. M. Califf. “Administration of thrombolytic therapy in the community hospital: established principles and unresolved issues.” J Am Coll Cardiol 12, no. 6 Suppl A (December 1988): 32A-43A. https://doi.org/10.1016/0735-1097(88)92639-3.
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  - Stack, R. S., R. M. Califf, T. Hinohara, H. R. Phillips, D. B. Pryor, C. A. Simonton, E. B. Carlson, K. G. Morris, V. S. Behar, and Y. Kong. “Survival and cardiac event rates in the first year after emergency coronary angioplasty for acute myocardial infarction.” J Am Coll Cardiol 11, no. 6 (June 1988): 1141–49. https://doi.org/10.1016/0735-1097(88)90274-4.
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  - Simonton, C. A., D. B. Mark, T. Hinohara, D. S. Rendall, H. R. Phillips, R. H. Peter, V. S. Behar, Y. Kong, W. G. O’Callaghan, and C. O’Connor. “Late restenosis after emergent coronary angioplasty for acute myocardial infarction: comparison with elective coronary angioplasty.” J Am Coll Cardiol 11, no. 4 (April 1988): 698–705. https://doi.org/10.1016/0735-1097(88)90198-2.
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  - Hlatky, M. A., H. Cotugno, C. O’Connor, D. B. Mark, D. B. Pryor, and R. M. Califf. “Adoption of thrombolytic therapy in the management of acute myocardial infarction.” Am J Cardiol 61, no. 8 (March 1, 1988): 510–14. https://doi.org/10.1016/0002-9149(88)90755-2.
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  - Hlatky, M. A., H. E. Cotugno, D. B. Mark, C. O’Connor, R. M. Califf, and D. B. Pryor. “Trends in physician management of uncomplicated acute myocardial infarction, 1970 to 1987.” Am J Cardiol 61, no. 8 (March 1, 1988): 515–18. https://doi.org/10.1016/0002-9149(88)90756-4.
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  - Stack, R. S., C. M. O’Connor, D. B. Mark, T. Hinohara, H. R. Phillips, M. M. Lee, N. M. Ramirez, W. G. O’Callaghan, C. A. Simonton, and E. B. Carlson. “Coronary perfusion during acute myocardial infarction with a combined therapy of coronary angioplasty and high-dose intravenous streptokinase.” Circulation 77, no. 1 (January 1988): 151–61. https://doi.org/10.1161/01.cir.77.1.151.
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  - Boswick, J. M., K. L. Lee, L. G. Aronson, C. M. O’Connor, M. B. Honan, R. M. Califf, and D. B. Pryor. “USE OF COMPUTERIZED STATISTICAL MODELS TO EDUCATE MEDICAL HOUSESTAFF IN ESTIMATING CLINICAL OUTCOMES.” Proceedings Annual Symposium on Computer Applications in Medical Care, December 1, 1987, 162–65.
  - Patronas, N. J., G. Di Chiro, R. A. Brooks, R. L. DeLaPaz, P. L. Kornblith, B. H. Smith, H. V. Rizzoli, et al. “Work in progress: [18F] fluorodeoxyglucose and positron emission tomography in the evaluation of radiation necrosis of the brain.” Radiology 144, no. 4 (September 1982): 885–89. https://doi.org/10.1148/radiology.144.4.6981123.
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  - Brooks, R. A., L. G. Mitchell, C. M. O’Connor, and G. Di Chiro. “On the relationship between computed tomography numbers and specific gravity.” Phys Med Biol 26, no. 1 (January 1981): 141–47. https://doi.org/10.1088/0031-9155/26/1/014.
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  - Rieth, K. G., K. Fujiwara, G. Di Chiro, I. Klatzo, R. A. Brooks, G. S. Johnston, C. M. O’Connor, and L. G. Mitchell. “Serial measurements of CT attenuation and specific gravity in experimental cerebral edema.” Radiology 135, no. 2 (May 1980): 343–48. https://doi.org/10.1148/radiology.135.2.6768102.
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  - Sheridan, W. T., M. R. Keller, C. M. O’Connor, R. A. Brooks, and K. M. Hanson. “Evaluation of edge-induced streaking artifacts in CT scanners.” Med Phys 7, no. 2 (March 1980): 108–11. https://doi.org/10.1118/1.594673.
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  - Koenig, Harold G., Christopher M. O’Connor, Steven A. Guarisco, K Michael Zabel, and Stephen M. Ford. “Depressive Disorder in Older Medical Inpatients on General Medicine and Cardiology Services at a University Teaching Hospital.” Am J Geriatr Psychiatry 1, no. 3 (n.d.): 197–210. https://doi.org/10.1097/00019442-199300130-00004.
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- Conference Papers
  - Tehrani, Behnam N., Alexander G. Truesdell, Matthew W. Sherwood, Shashank Desai, Henry A. Tran, Kelly C. Epps, Ramesh Singh, et al. “Standardized Team-Based Care for Cardiogenic Shock.” In Journal of the American College of Cardiology, 73:1659–69, 2019. https://doi.org/10.1016/j.jacc.2018.12.084.
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  - Mentz, Robert J., Christopher M. O’Connor, Bradi B. Granger, Hongqiu Yang, Chetan B. Patel, Karen E. Steinhauser, Mona Fiuzat, et al. “Palliative care and hospital readmissions in patients with advanced heart failure: Insights from the PAL-HF trial.” In Am Heart J, 204:202–4, 2018. https://doi.org/10.1016/j.ahj.2018.07.010.
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  - Pokorney, Sean D., Sana M. Al-Khatib, Jie-Lena Sun, Phillip Schulte, Christopher M. O’Connor, John R. Teerlink, Paul W. Armstrong, et al. “Sudden cardiac death after acute heart failure hospital admission: insights from ASCEND-HF.” In European Journal of Heart Failure, 20:525–32, 2018. https://doi.org/10.1002/ejhf.1078.
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  - DeVore, Adam D., Vic Hasselblad, Robert J. Mentz, Christopher M. O’Connor, Paul W. Armstrong, John J. McMurray, Justin A. Ezekowitz, et al. “Loop diuretic dose adjustments after a hospitalization for heart failure: insights from ASCEND-HF.” In Eur J Heart Fail, 17:340–46, 2015. https://doi.org/10.1002/ejhf.235.
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  - Valente, Mattia A. E., Adriaan A. Voors, Kevin Damman, Dirk J. Van Veldhuisen, Barrie M. Massie, Christopher M. O’Connor, Marco Metra, et al. “Diuretic response in acute heart failure: clinical characteristics and prognostic significance.” In Eur Heart J, 35:1284–93, 2014. https://doi.org/10.1093/eurheartj/ehu065.
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  - Wilcox, Jane E., Gregg C. Fonarow, Yan Zhang, Nancy M. Albert, Anne B. Curtis, Mihai Gheorghiade, J Thomas Heywood, et al. “Clinical effectiveness of cardiac resynchronization and implantable cardioverter-defibrillator therapy in men and women with heart failure: findings from IMPROVE HF.” In Circ Heart Fail, 7:146–53, 2014. https://doi.org/10.1161/CIRCHEARTFAILURE.113.000789.
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