Overview
Dr. Alekseev completed combined MD-PhD training at Drexel University College of Medicine and pursued post-doctoral fellowship training at the University of Pennsylvania School of Medicine. He completed Ophthalmology residency training at the University of North Carolina School of Medicine, where he also served as a chief resident. Dr. Alekseev pursued double-fellowship training in Medical Retina and Inherited Retinal Degenerations at the Duke Eye Center, where he then joined the faculty in 2022.
Dr. Alekseev is a member of the Duke Center for Retinal Degenerations and Ophthalmic Genetic Diseases. His clinical focus is on inherited retinal degenerations, including conditions like retinitis pigmentosa, Stargardt disease, macular pattern dystrophies, syndromic retinal degenerations, and mimickers like autoimmune and iatrogenic retinopathies. Dr. Alekseev’s patients have access to advanced diagnostic modalities, including electrophisiology testing, various types of perimetry testing, specialized retinal imaging, as well as genetic testing. In addition to his practice, Dr. Alekseev conducts clinical trials in rare genetic conditions of the retina, such as choroideremia and retinitis pigmentosa.
As a K08-scholar, Dr. Alekseev dedicates the majority of his time to basic and translational research in the laboratory. He is interested in developing gene-agnostic approaches to extend the longevity of ailing photoreceptors in conditions like retinitis pigmentosa, thereby preserving the vision of affected patients. The approaches he investigates include both gene-therapy and small-molecule-based therapeutic modalities.
Current Appointments & Affiliations
Recent Publications
Unique ultrastructural organization of human rod photoreceptors.
Journal Article Commun Biol · January 16, 2025 Rod and cone photoreceptor cells are specialized neurons responsible for transforming the information reaching the eyes in the form of photons into the language of neuronal activity. Rods are the most prevalent photoreceptor type, primarily responsible for ... Full text Link to item CiteMystery of changing choroidal thickness.
Journal Article Retina · December 1, 2022 Full text Link to item CiteRetinal and optic nerve inflammatory findings are a common feature in patients with USH2A-associated retinal degeneration
Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · 2022 Link to item CiteRecent Grants
A Phase Ib, Open-Label Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Orally Administered DF-003 in ROSAH Syndrome Patients
Clinical TrialPrincipal Investigator · Awarded by Shanghai Yao Yuan Biotechnology, Ltd _ AKA Drug Farm · 2025 - 2030Defining the underlying causes of retinal degeneration in CRB1 disease
ResearchCo Investigator · Awarded by Foundation Fighting Blindness, Inc · 2024 - 2029A Phase 1b Open-label Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Tinlarebant in Japanese Subjects with Stargardt Disease and a Phase 2/3, Randomized, Double masked, and Placebo controlled Study to Evaluate
Clinical TrialPrincipal Investigator · Awarded by Belite Bio (HK) Limited · 2024 - 2029View All Grants