Scholars@Duke
Patricia Angellice Martinez Quinones

Patricia Angellice Martinez Quinones

Assistant Professor of Surgery
Trauma, Acute, and Critical Care Surgery

Selected Publications

Advancing Surgical Infection Science in the Americas: Highlights from the 2025 Panamerican Trauma Congress.

Journal Article Surg Infect (Larchmt) · February 1, 2026 Surgical site infections (SSIs) and other infectious complications remain a major cause of preventable morbidity across Latin America. SSI prevalence in elective clean and clean-contaminated procedures in Latin America is substantial, and rates may increas ... Full text Link to item Cite

Adapting to Change: Proposed Next Steps for an Evolving and More Inclusive American Board of Surgery Examination Paradigm.

Journal Article J Surg Educ · January 2026 Since its foundation in 1937, the American Board of Surgery (ABS) has provided board certification for surgeons who have met rigorous standards of education, training, and professional requirements in general surgery. The ABS regulates the administration o ... Full text Link to item Cite

Sex-related differences in cognition after severe murine traumatic brain injury: A Morris water maze study evaluating learning and memory.

Journal Article J Trauma Acute Care Surg · November 1, 2025 BACKGROUND: A number of sex-related outcomes following severe traumatic brain injury (TBI) appear to principally favor females. However, sex-related differences in post-TBI learning and memory remain underexplored. We hypothesized that females realize grea ... Full text Link to item Cite

The importance of diversity within surgical education.

Journal Article Curr Probl Surg · September 2025 Full text Link to item Cite

Association between a 6-h feeding protocol and postprocedure hospital length of stay following percutaneous endoscopic gastrostomy in hospitalized adults: A before-and-after cohort study.

Journal Article JPEN J Parenter Enteral Nutr · February 2025 BACKGROUND: Tolerance of enteral nutrition following percutaneous endoscopic gastrostomy is a barrier to discharge. This study investigated the impact of an expedited feeding protocol following percutaneous endoscopic gastrostomy on postprocedure length of ... Full text Link to item Cite

Daily quetiapine after severe TBI improves learning and memory.

Journal Article J Trauma Acute Care Surg · November 1, 2024 BACKGROUND: Traumatic brain injury (TBI) induces cognitive deficits driven by neuroinflammation and cerebral edema. The commonly used atypical antipsychotic, quetiapine (QTP), has been recently shown to improve post-TBI outcomes. We hypothesized that QTP w ... Full text Link to item Cite

Another brick in the wall

Journal Article Trauma Surgery and Acute Care Open · August 5, 2024 Full text Cite

The impact of hypertonic saline on damage control laparotomy after penetrating abdominal trauma.

Journal Article Eur J Trauma Emerg Surg · June 2024 PURPOSE: The inability to achieve primary fascial closure (PFC) after emergency laparotomy increases the rates of adverse outcomes including fistula formation, incisional hernia, and intraabdominal infection. Hypertonic saline (HTS) infusion improves early ... Full text Link to item Cite

The impact of hypertonic saline on damage control laparotomy after penetrating abdominal trauma

Journal Article EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY · 2024 Full text Cite

Conundrums in the surgical intensive care unit: fevers and antibiotic prophylaxis.

Journal Article Trauma Surg Acute Care Open · 2024 This editorial is in response to the three latest clinical consensus guidelines authored by the Critical Care Committee of the American Association for the Surgery of Trauma. Herein, we discuss their main findings and recommendations and their impact on th ... Full text Link to item Cite

Assessing the Impact of Hands-Free Georgia on Serious Motor Vehicle Accidents.

Journal Article Am Surg · November 2023 BACKGROUND: Hands-Free Georgia Law (HB673) was designed to prevent motor vehicle collisions (MVCs) by banning drivers from using their hands for non-driving-related activities, including cell phone use. We investigate HB673 effect on trauma activations sec ... Full text Link to item Cite

Crosstalk in the Abdomen: The Interface of the Omentum and the Microbiome in Sepsis.

Journal Article Surg Infect (Larchmt) · April 2023 Previously considered inert, the greater omentum is now thought to play a central role in intra-peritoneal immune defense. The intestinal microbiome has recently become a target for potential therapeutic interventions. A narrative review of the immune func ... Full text Link to item Cite

Effective use of weight-based enoxaparin for deep vein thrombosis chemoprophylaxis in patients with traumatic brain injury.

Journal Article Am J Surg · January 2022 BACKGROUND: Enoxaparin is the recommended agent for deep vein thrombosis (DVT) chemoprophylaxis in trauma patients. Current literature suggests weight-based dosing is superior to standard dosing for adequate chemoprophylaxis. Literature regarding the use o ... Full text Link to item Cite

Achievement of goal anti-Xa activity with weight-based enoxaparin dosing for venous thromboembolism prophylaxis in trauma patients.

Journal Article Pharmacotherapy · June 2021 STUDY OBJECTIVE: The purpose of this study was to evaluate the utility of routine anti-Xa peak monitoring for trauma patients initiated on weight-based enoxaparin for venous thromboembolism (VTE) prophylaxis and identify patient populations where monitorin ... Full text Link to item Cite

Gender Equity at Surgical Conferences: Quantity and Quality.

Journal Article J Surg Res · February 2021 BACKGROUND: Participation of women at national surgery conferences is an important aspect of achieving gender equity; however, participation has to be meaningful and representative of scientific and clinical achievement. We hypothesized that the presence o ... Full text Link to item Cite

A basic solution to activate the cholinergic anti-inflammatory pathway via the mesothelium?

Journal Article Pharmacol Res · March 2019 Much research now indicates that vagal nerve stimulation results in a systemic reduction in inflammatory cytokine production and an increase in anti-inflammatory cell populations that originates from the spleen. Termed the 'cholinergic anti-inflammatory pa ... Full text Link to item Cite

Targeting Endothelial Barrier Dysfunction Caused by Circulating Bacterial and Mitochondrial N-Formyl Peptides With Deformylase.

Journal Article Front Immunol · 2019 Despite recent advances in our understanding of the mechanisms underlying systemic inflammatory response syndrome (SIRS) and sepsis, the current therapeutic approach to these critically ill patients is centered around supportive care including fluid resusc ... Full text Link to item Cite

Hypertension Induced Morphological and Physiological Changes in Cells of the Arterial Wall.

Journal Article Am J Hypertens · September 11, 2018 Morphological and physiological changes in the vasculature have been described in the evolution and maintenance of hypertension. Hypertension-induced vascular dysfunction may present itself as a contributing, or consequential factor, to vascular remodeling ... Full text Link to item Cite

Increase in soluble protein oligomers triggers the innate immune system promoting inflammation and vascular dysfunction in the pathogenesis of sepsis.

Journal Article Clin Sci (Lond) · July 18, 2018 Sepsis is a profoundly morbid and life-threatening condition, and an increasingly alarming burden on modern healthcare economies. Patients with septic shock exhibit persistent hypotension despite adequate volume resuscitation requiring pharmacological vaso ... Full text Link to item Cite

Peritoneal cavity lavage reduces the presence of mitochondrial damage associated molecular patterns in open abdomen patients.

Conference J Trauma Acute Care Surg · December 2017 BACKGROUND: Mitochondrial damage-associated molecular patterns (mtDAMPs), such as mitochondrial DNA and N-formylated peptides, are endogenous molecules released from tissue after traumatic injury. mtDAMPs are potent activators of the innate immune system. ... Full text Link to item Cite

Out of the frying pan and into the fire: damage-associated molecular patterns and cardiovascular toxicity following cancer therapy.

Journal Article Ther Adv Cardiovasc Dis · November 2017 Cardio-oncology is a new and rapidly expanding field that merges cancer and cardiovascular disease. Cardiovascular disease is an omnipresent side effect of cancer therapy; in fact, it is the second leading cause of death in cancer survivors after recurrent ... Full text Link to item Cite

Disparities in Laparoscopic Resection in the Elective Treatment of Diverticulitis

Conference Journal of the American College of Surgeons · October 2017 Full text Cite

Profile of the average organ non-donor: can it be used predictively?

Journal Article P R Health Sci J · September 2014 OBJECTIVE: To describe the profile of the average organ non-donor, compare it to that of the average donor, and identify characteristics that predict the likelihood that a given individual will be a non-donor. METHODS: The charts of 397 consenting potentia ... Link to item Cite