Scholars@Duke
Patrick Mulcahey

Patrick Mulcahey

Student
Neurobiology

Selected Publications

Motor network reorganization associated with rTMS-induced writing improvement in writer's cramp dystonia.

Journal Article Brain Stimul · 2025 BACKGROUND: Writer's cramp (WC) dystonia is an involuntary movement disorder with distributed abnormalities in the brain's motor network. Prior studies established the potential for repetitive transcranial magnetic stimulation (rTMS) to either premotor cor ... Full text Link to item Cite

Motor priming induces changes in resting state dynamics in cerebellum of writer’s cramp dystonia: insights for clinical therapies

Journal Article Dystonia · January 1, 2025 Background: Writer’s cramp (WC) is an adult-onset focal dystonia that impairs hand and arm movements during writing tasks. Previous studies have identified abnormal resting state connectivity between the basal ganglia and cerebellum in WC. However, the rol ... Full text Cite

Electroencephalographic Correlates of Clinical Severity in the Natural history study of RTT and Related Disorders.

Journal Article Annals of neurology · July 2024 ObjectiveThis study was undertaken to characterize quantitative electroencephalographic (EEG) features in participants from the Natural history study of RTT and Related Disorders and to assess the potential for these features to act as objective m ... Full text Cite

Transcranial magnetic stimulation: the road to clinical therapy for dystonia

Journal Article Dystonia · January 1, 2023 Despite many research studies, transcranial magnetic stimulation (TMS) is not yet an FDA-approved clinical therapy for dystonia patients. This review describes the four major challenges that have historically hindered the clinical translation of TMS. The f ... Full text Open Access Cite

Quantitative electroencephalographic analysis as a potential biomarker of response to treatment with cannabidiol.

Journal Article Epilepsy research · September 2022 PurposePharmaceutical grade cannabidiol (CBD) is one of the newest anti-seizure medications for refractory epilepsy, and the effects of CBD on EEG have not been fully described.MethodsPatients enrolled in a CBD expanded access study had E ... Full text Cite

Multimodal, Multiscale Insights into Hippocampal Seizures Enabled by Transparent, Graphene-Based Microelectrode Arrays.

Journal Article eNeuro · May 2022 Hippocampal seizures are a defining feature of mesial temporal lobe epilepsy (MTLE). Area CA1 of the hippocampus is commonly implicated in the generation of seizures, which may occur because of the activity of endogenous cell populations or of inputs from ... Full text Cite

Distinctive Adsorption Mechanism and Kinetics of Immunoglobulin G on a Nanoscale Polymer Surface.

Journal Article Langmuir : the ACS journal of surfaces and colloids · February 2022 Elucidation of protein adsorption beyond simple polymer surfaces to those presenting greater chemical complexity and nanoscopic features is critical to developing well-controlled nanobiomaterials and nanobiosensors. In this study, we repeatedly and faithfu ... Full text Cite

Electrophysiological biomarkers of brain function in CDKL5 deficiency disorder.

Journal Article Brain communications · January 2022 CDKL5 deficiency disorder is a debilitating developmental and epileptic encephalopathy for which no targeted treatment exists. A number of promising therapeutics are under development for CDKL5 deficiency disorder but a lack of validated biomarkers of brai ... Full text Cite

Assessing clinical trunk change with surface topography: anterior scoliosis correction as a model to evaluate curve progression.

Journal Article European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · December 2021 PurposePrevious work has suggested that surface topography can be used for repeated measurements of deformity during curve monitoring following an initial radiograph. Changes in deformity during natural curve progression may be subtle. An importan ... Full text Cite

An inertial sensor-based protocol for spinal range of motion measurements.

Journal Article Studies in health technology and informatics · June 2021 To develop a protocol for assessing spinal range of motion using an inertial sensor device. The baseline error of an inertial sensor was assessed using a bicycle wheel. Nineteen healthy subjects (12 females and 7 males, average age 18.2 ± 0.6 years) were t ... Full text Cite

Aged heterozygous Cdkl5 mutant mice exhibit spontaneous epileptic spasms.

Journal Article Experimental neurology · October 2020 CDKL5 deficiency disorder (CDD) is a devastating neurodevelopmental disorder characterized by early-onset epilepsy, severe intellectual disability, cortical visual impairment and motor disabilities. Epilepsy is a central feature of CDD, with most patients ... Full text Cite

A gel-free Ti3C2Tx-based electrode array for high-density, high-resolution surface electromyography.

Journal Article Advanced materials technologies · August 2020 Wearable sensors for surface electromyography (EMG) are composed of single- to few-channel large-area contacts, which exhibit high interfacial impedance and require conductive gels or adhesives to record high-fidelity signals. These devices are also limite ... Full text Cite

Revealing the principal attributes of protein adsorption on block copolymer surfaces with direct experimental evidence at the single protein level.

Journal Article Nanoscale · May 2018 Understanding protein adsorption onto polymer surfaces is of great importance in designing biomaterials, improving bioanalytical devices, and controlling biofouling, to name a few examples. Although steady research efforts have been advancing this field, o ... Full text Cite

Surface Assembly Configurations and Packing Preferences of Fibrinogen Mediated by the Periodicity and Alignment Control of Block Copolymer Nanodomains.

Journal Article ACS nano · August 2016 The ability to control the specific adsorption and packing behaviors of biomedically important proteins by effectively guiding their preferred surface adsorption configuration and packing orientation on polymeric surfaces may have utility in many applicati ... Full text Cite