Pawan Dahal

Journal Article Proceedings of the National Academy of Sciences of the United States of America · October 2022 AAA+ ATPases are ubiquitous proteins associated with most cellular processes, including DNA unwinding and protein unfolding. Their functional and structural properties are typically determined by domains and motifs added to the conserved ATPases domain. Cu ... Full text Open Access Cite

Structural analysis of the regulation of blue-light receptors by GIGANTEA.

Journal Article Cell reports · April 2022 In Arabidopsis, GIGANTEA (GI), together with the blue-light receptors ZTL, LKP2, and FKF1, regulates degradation of the core clock protein TOC1 and the flowering repressor CDFs, thereby controlling circadian oscillation and flowering. Despite the significa ... Full text Cite

Crystal structure of a tandem B-box domain from Arabidopsis CONSTANS.

Journal Article Biochemical and biophysical research communications · April 2022 CONSTANS is a central protein in the regulation of photoperiodic flowering, which is expressed in response to day length and promotes the expression of Flowering Locus T. The tandem B-box domain in CONSTANS mediates interactions with various proteins to re ... Full text Cite

Crystal structure of the DNA-binding domain of Bacillus subtilis CssR.

Journal Article Biochemical and biophysical research communications · May 2021 Bacteria utilize two-component systems to regulate gene expression in response to changes in environmental stimuli. CssS/CssR, a two-component system in Bacillus subtilis, is responsible for overcoming envelope stresses caused by heat shock and secretion o ... Full text Cite

Structural insights into stressosome assembly

Journal Article IUCrJ · September 1, 2019 The stressosome transduces environmental stress signals to SigB to upregulate SigB-dependent transcription, which is required for bacterial viability. The stressosome core is composed of RsbS and at least one of the RsbR paralogs. A previous cryo-electron ... Full text Cite

Structural analysis of the recognition of the -35 promoter element by SigW from Bacillus subtilis.

Journal Article PloS one · January 2019 Sigma factors are key proteins that mediate the recruitment of RNA polymerase to the promoter regions of genes, for the initiation of bacterial transcription. Multiple sigma factors in a bacterium selectively recognize their cognate promoter sequences, the ... Full text Cite