Research Interests
Brain Tumor Immunotherapy
Cancer-Induced Immune Dysfunction
Glioblastoma
Brain Metastasis
Cancer-Induced Immune Dysfunction
Glioblastoma
Brain Metastasis
Selected Grants
Identifying and exploiting therapeutic vulnerabilities of tumor-host interactions that drive bone-to-meninges breast cancer metastasis
ResearchCo Investigator · Awarded by National Institutes of Health · 2023 - 2028Phase 2 trial of a novel peptide vaccine targeting CMV antigen for newly diagnosed pediatric high grade glioma and diffuse intrinsic pontine glioma and recurrent medulloblastoma
ResearchInvestigator · Awarded by Food and Drug Administration · 2021 - 2027Medical Scientist Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027REcurrent brain Metastases After SRS Trial
Clinical TrialPrincipal Investigator · Awarded by Monteris Medical, Inc. · 2021 - 2026Licensing Immunotherapeutic Responses in GBM: Developing A Novel GPCR-Targeted Approach
ResearchPrincipal Investigator · Awarded by Charlie Teo Foundation · 2024 - 2026Bypassing tumor heterogeneity with an optimized EGFR/ EGFRvIII bi-specific CAR T cell that secretes TIM4 BLT
ResearchPrincipal Investigator · Awarded by ARCE Therapeutics · 2024 - 2026Nervous system control and regulation of the immune system following neurological insults
ResearchMentor · Awarded by National Institute of Neurological Disorders and Stroke · 2023 - 2026Removing Barriers to Immunotherapy Against Tumors Within the Intracranial Compartment
ResearchPrincipal Investigator · Awarded by Cancer Research Institute · 2021 - 2026Targeting tumor-neural cell interactions to inhibit lung cancer brain metastasis
ResearchCollaborating Investigator · Awarded by National Institutes of Health · 2021 - 2026Tunable Temporal Drug Release for Optimized Synergistic Combination Therapy of Glioblastoma
ResearchPrincipal Investigator · Awarded by University of North Carolina - Chapel Hill · 2021 - 2025NINDS Research Education Programs for Residents and Fellows in Neurosurgery
Inst. Training Prgm or CMEPrincipal Investigator · Awarded by National Institute of Neurological Disorders and Stroke · 2009 - 2025Basic Immunology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2020 - 2025Mechanistic insights into immune suppression in brain tumors: a role for beta-arrestin 2
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2025A Novel TIM4 Bi-Specific T cell Engager Sidesteps Tumor Heterogeneity
ResearchPrincipal Investigator · Awarded by Sontag Foundation · 2023 - 2025Chimeric Antigen Receptor-T cells Engineered with Bi-specific Engager without Antigen Requirements (The CARE BEAR Project)
ResearchPrincipal Investigator · Awarded by Uncle Kory Foundation · 2024 - 2024Duke CTSA (TL1) Year 5
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2018 - 2024Laser Ablation of Abnormal Neurolgoical Tissue using Robotic Neuroblate System (LAANTERN) Prospective Registry
Clinical TrialPrincipal Investigator · Awarded by Monteris Medical, Inc. · 2016 - 2023Development of BARR2 Small Molecule Inhibitors for Brain Cancer Therapy
ResearchPrincipal Investigator · Awarded by Charlie Teo Foundation · 2021 - 2023T32 UNC - Duke Immunotherapy Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by University of North Carolina - Chapel Hill · 2021 - 2022Translational Research in Surgical Oncology
Inst. Training Prgm or CMECo-Mentor · Awarded by National Institutes of Health · 2002 - 2022The Role of CD155 in Leptomeningeal Dissemination and Oncolytic Virus Susceptibility in the Medulloblastoma Microenvironment
ResearchSignificant Contributor · Awarded by Department of Defense · 2018 - 2022Validation of Novel Therapeutic Approach for Leptomeningeal Metastases
ResearchCo Investigator · Awarded by Minnetronix, Inc · 2016 - 2022Medical Scientist Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1997 - 2022A Novel Clinical Challenge in Brain Tumor Immunology: T cell Sequestration
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2021Identification of actionable networks promoting breast cancer progression and brain metastasis
ResearchCollaborator · Awarded by Department of Defense · 2018 - 2021Lost and Found: The Bone Marrow as Counterproductive Site of T cell Sequestration in GBM
ResearchPrincipal Investigator · Awarded by Sontag Foundation · 2015 - 2019LITT and Short Course Radiation for Patients with GBM Requiring Standard Treatment Alternatives (LASR)
Clinical TrialPrincipal Investigator · Awarded by Monteris Medical, Inc. · 2017 - 2019Directed Chemotherapy Delivery for Leptomeningeal Metastases
ResearchCo Investigator · Awarded by Minnetronix, Inc · 2016 - 2017External Relationships
- Monteris Medical
- clearview
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.