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Peter Michael Grossi

Associate Professor of Neurosurgery
Neurosurgery
3480 Wake Forest Rd, Suite 310, Raleigh, NC 27609
3840 Wake Forest Rd, Suite 310, Raleigh, NC 27609

Selected Publications


Clinical and Radiographic Outcomes for Patients with Cervical Adjacent Segment Disease Treated with Anterior Cervical Discectomy and Fusion with Integrated Interbody Spacers.

Journal Article World Neurosurg · December 2023 INTRODUCTION: Anterior cervical discectomy and fusion (ACDF) is among the most common spine procedures. Adjacent segment disease (ASD), characterized by degenerative disease at an adjacent spinal level to a prior fusion, is a well-recognized and significan ... Full text Link to item Cite

Sacroiliac Joint Fusion Using Robotic Navigation: Technical Note and Case Series.

Conference Oper Neurosurg (Hagerstown) · July 1, 2022 BACKGROUND: Patients undergoing sacroiliac (SI) fusion can oftentimes experience significant improvements in pain and quality of life. OBJECTIVE: To describe a novel application of robotic navigation to assist with minimally invasive SI joint fusion. METHO ... Full text Link to item Cite

Coupling Hematoma Evacuation with Immune Profiling for Analysis of Neuroinflammation After Primary Intracerebral Hemorrhage: A Pilot Study.

Journal Article World Neurosurg · May 2022 OBJECTIVE: We sought to explore the use and feasibility of an integrated hematoma evacuation/tissue preservation system coupled with immune profiling to assess human ex vivo immune cell populations from brain hematoma samples after intracerebral hemorrhage ... Full text Link to item Cite

Two-Level Minimally Invasive Lumbar Laminectomy and Foraminotomy: 2-Dimensional Operative Video.

Journal Article Oper Neurosurg (Hagerstown) · August 16, 2021 Minimally invasive lumbar laminectomies utilize tubular retractors to minimize tissue disturbance, blood loss, and hospital length of stay compared to open operations. Here, we highlight the operative treatment of a 68-yr-old male entailing a 2-level minim ... Full text Link to item Cite

Glioblastoma in the elderly: the effect of aggressive and modern therapies on survival.

Journal Article J Neurosurg · April 2016 OBJECTIVE: The prognosis of elderly patients with glioblastoma (GBM) is universally poor. Currently, few studies have examined postoperative outcomes and the effects of various modern therapies such as bevacizumab on survival in this patient population. In ... Full text Link to item Cite

Initial experience with extreme angle cervical screw for treatment of trauma and cervical spondylosis.

Journal Article Surg Technol Int · March 2014 In this study, we have described our initial experience and surgical technique of extreme angle screw placement in the cervical and upper thoracic spine of a cohort of patients undergoing posterior fusion. This extreme angle screw facilitates rod placement ... Link to item Cite

Insurance disparities in the outcomes of spinal cord stimulation surgery.

Journal Article Neuromodulation · 2013 OBJECTIVES: The Affordable Care Act aims to expand health insurance and to help narrow existing health care disparities. Medicaid patients have previously been noted to be at an increased risk for impaired access to health care, delayed medical treatment, ... Full text Link to item Cite

Comparison of superior-level facet joint violations during open and percutaneous pedicle screw placement.

Journal Article Neurosurgery · November 2012 BACKGROUND: Superior-level facet joint violation by pedicle screws may result in increased stress to the level above the instrumentation and may contribute to adjacent segment disease. Previous studies have evaluated facet joint violations in open or percu ... Full text Link to item Cite

The history of the combined supra- and infratentorial approach to the petroclival region.

Journal Article Neurosurg Focus · August 2012 Lesions of the ventrolateral brainstem, clivus, and cerebellopontine angle pose significant challenges for surgeons, and the rate of morbidity and mortality from classic neurosurgical approaches has proven to be unacceptably high. Early attempts to expose ... Full text Link to item Cite

Microsurgical management of hypoglossal schwannomas over 3 decades: a modified grading scale to guide surgical approach.

Journal Article Neurosurgery · December 2011 BACKGROUND: Schwannomas originating from the hypoglossal nerve are extremely rare. Microsurgical resection with the goal for cure has traditionally been associated with a high risk of postoperative deficits. OBJECTIVE: To summarize our clinical experience ... Full text Link to item Cite

Minimally invasive lumbar interbody fusion in patients older than 70 years of age: analysis of peri- and postoperative complications.

Journal Article Neurosurgery · April 2011 BACKGROUND: The number of spine operations performed in the elderly population is rising. OBJECTIVE: To identify and describe perioperative and postoperative complications in patients 70 years and older who have undergone minimally invasive lumbar interbod ... Full text Link to item Cite

Response

Journal Article Journal of Neurosurgery · December 1, 2010 Full text Cite

Unilateral hypoglossal nerve palsy caused by an intraneural ganglion cyst.

Journal Article J Neurosurg · August 2010 The authors describe a rare case of unilateral hypoglossal nerve palsy caused by an intraneural ganglion cyst. Three similar cases have been reported with pathological classification still under consideration. One case was classified as an intraneural gang ... Full text Link to item Cite

Response of malignant scalp dermatofibrosarcoma to presurgical targeted growth factor inhibition.

Journal Article J Neurosurg · May 2010 Dermatofibrosarcoma protuberans (DFSP) is an uncommon, locally aggressive, malignant cutaneous tumor that sparingly presents on the scalp. Dermatofibrosarcomas often result from the formation of a fusion oncogene on translocated or supernumerary ring chrom ... Full text Link to item Cite

Cholesterol granuloma of the lateral ventricle. Case report.

Journal Article J Neurosurg · February 2008 Cholesterol granulomas (CGs) are benign lesions resulting from an inflammatory reaction to cholesterol and hemosiderin. These masses most often arise within the temporal bone or nasal sinuses; intracerebral CGs are extremely rare. In this report the author ... Full text Link to item Cite

Systemic CTLA-4 blockade ameliorates glioma-induced changes to the CD4+ T cell compartment without affecting regulatory T-cell function.

Journal Article Clin Cancer Res · April 1, 2007 PURPOSE: Patients with malignant glioma suffer global compromise of their cellular immunity, characterized by dramatic reductions in CD4(+) T cell numbers and function. We have previously shown that increased regulatory T cell (T(reg)) fractions in these p ... Full text Link to item Cite

Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity.

Journal Article J Neuroimmunol · January 2007 For the study of malignant glioma, we have previously characterized a highly tumorigenic murine astrocytoma, SMA-560, which arose spontaneously in an inbred, immunocompetent VM/Dk mouse. Using this cell line as a model of murine glioma, we performed DNA mi ... Full text Link to item Cite

Ventriculoperitoneal shunt failure causing myelopathy in a patient with bilateral jugular vein occlusion. Case report.

Journal Article J Neurosurg Spine · January 2007 The authors describe the case of a 36-year-old woman with bilateral internal jugular vein occlusion, hydrocephalus, and Dandy-Walker variant who presented with myelopathy that was ultimately attributed to ventriculoperitoneal (VP) shunt failure. Computed t ... Full text Link to item Cite

Systemic anti-CD25 monoclonal antibody administration safely enhances immunity in murine glioma without eliminating regulatory T cells.

Journal Article Clin Cancer Res · July 15, 2006 PURPOSE: Elevated proportions of regulatory T cells (T(reg)) are present in patients with a variety of cancers, including malignant glioma, yet recapitulative murine models are wanting. We therefore examined T(regs) in mice bearing malignant glioma and eva ... Full text Link to item Cite

Systemic hemostasis with recombinant-activated factor VII followed by local thrombolysis with recombinant tissue plasminogen activator in intraventricular hemorrhage.

Journal Article Neurocrit Care · 2005 INTRODUCTION: A 51-year-old woman on warfarin thromboprophylaxis for transient ischemic attacks developed sudden onset nausea, vomiting, and decreased mental status, rapidly becoming comatose. Head computed tomography (CT) showed intracerebral hemorrhage, ... Full text Link to item Cite

Clinical and Radiographic Outcomes for Patients with Cervical Adjacent Segment Disease Treated with Anterior Cervical Discectomy and Fusion with Integrated Interbody Spacers.

Journal Article World Neurosurg · December 2023 INTRODUCTION: Anterior cervical discectomy and fusion (ACDF) is among the most common spine procedures. Adjacent segment disease (ASD), characterized by degenerative disease at an adjacent spinal level to a prior fusion, is a well-recognized and significan ... Full text Link to item Cite

Sacroiliac Joint Fusion Using Robotic Navigation: Technical Note and Case Series.

Conference Oper Neurosurg (Hagerstown) · July 1, 2022 BACKGROUND: Patients undergoing sacroiliac (SI) fusion can oftentimes experience significant improvements in pain and quality of life. OBJECTIVE: To describe a novel application of robotic navigation to assist with minimally invasive SI joint fusion. METHO ... Full text Link to item Cite

Coupling Hematoma Evacuation with Immune Profiling for Analysis of Neuroinflammation After Primary Intracerebral Hemorrhage: A Pilot Study.

Journal Article World Neurosurg · May 2022 OBJECTIVE: We sought to explore the use and feasibility of an integrated hematoma evacuation/tissue preservation system coupled with immune profiling to assess human ex vivo immune cell populations from brain hematoma samples after intracerebral hemorrhage ... Full text Link to item Cite

Two-Level Minimally Invasive Lumbar Laminectomy and Foraminotomy: 2-Dimensional Operative Video.

Journal Article Oper Neurosurg (Hagerstown) · August 16, 2021 Minimally invasive lumbar laminectomies utilize tubular retractors to minimize tissue disturbance, blood loss, and hospital length of stay compared to open operations. Here, we highlight the operative treatment of a 68-yr-old male entailing a 2-level minim ... Full text Link to item Cite

Glioblastoma in the elderly: the effect of aggressive and modern therapies on survival.

Journal Article J Neurosurg · April 2016 OBJECTIVE: The prognosis of elderly patients with glioblastoma (GBM) is universally poor. Currently, few studies have examined postoperative outcomes and the effects of various modern therapies such as bevacizumab on survival in this patient population. In ... Full text Link to item Cite

Initial experience with extreme angle cervical screw for treatment of trauma and cervical spondylosis.

Journal Article Surg Technol Int · March 2014 In this study, we have described our initial experience and surgical technique of extreme angle screw placement in the cervical and upper thoracic spine of a cohort of patients undergoing posterior fusion. This extreme angle screw facilitates rod placement ... Link to item Cite

Insurance disparities in the outcomes of spinal cord stimulation surgery.

Journal Article Neuromodulation · 2013 OBJECTIVES: The Affordable Care Act aims to expand health insurance and to help narrow existing health care disparities. Medicaid patients have previously been noted to be at an increased risk for impaired access to health care, delayed medical treatment, ... Full text Link to item Cite

Comparison of superior-level facet joint violations during open and percutaneous pedicle screw placement.

Journal Article Neurosurgery · November 2012 BACKGROUND: Superior-level facet joint violation by pedicle screws may result in increased stress to the level above the instrumentation and may contribute to adjacent segment disease. Previous studies have evaluated facet joint violations in open or percu ... Full text Link to item Cite

The history of the combined supra- and infratentorial approach to the petroclival region.

Journal Article Neurosurg Focus · August 2012 Lesions of the ventrolateral brainstem, clivus, and cerebellopontine angle pose significant challenges for surgeons, and the rate of morbidity and mortality from classic neurosurgical approaches has proven to be unacceptably high. Early attempts to expose ... Full text Link to item Cite

Microsurgical management of hypoglossal schwannomas over 3 decades: a modified grading scale to guide surgical approach.

Journal Article Neurosurgery · December 2011 BACKGROUND: Schwannomas originating from the hypoglossal nerve are extremely rare. Microsurgical resection with the goal for cure has traditionally been associated with a high risk of postoperative deficits. OBJECTIVE: To summarize our clinical experience ... Full text Link to item Cite

Minimally invasive lumbar interbody fusion in patients older than 70 years of age: analysis of peri- and postoperative complications.

Journal Article Neurosurgery · April 2011 BACKGROUND: The number of spine operations performed in the elderly population is rising. OBJECTIVE: To identify and describe perioperative and postoperative complications in patients 70 years and older who have undergone minimally invasive lumbar interbod ... Full text Link to item Cite

Response

Journal Article Journal of Neurosurgery · December 1, 2010 Full text Cite

Unilateral hypoglossal nerve palsy caused by an intraneural ganglion cyst.

Journal Article J Neurosurg · August 2010 The authors describe a rare case of unilateral hypoglossal nerve palsy caused by an intraneural ganglion cyst. Three similar cases have been reported with pathological classification still under consideration. One case was classified as an intraneural gang ... Full text Link to item Cite

Response of malignant scalp dermatofibrosarcoma to presurgical targeted growth factor inhibition.

Journal Article J Neurosurg · May 2010 Dermatofibrosarcoma protuberans (DFSP) is an uncommon, locally aggressive, malignant cutaneous tumor that sparingly presents on the scalp. Dermatofibrosarcomas often result from the formation of a fusion oncogene on translocated or supernumerary ring chrom ... Full text Link to item Cite

Cholesterol granuloma of the lateral ventricle. Case report.

Journal Article J Neurosurg · February 2008 Cholesterol granulomas (CGs) are benign lesions resulting from an inflammatory reaction to cholesterol and hemosiderin. These masses most often arise within the temporal bone or nasal sinuses; intracerebral CGs are extremely rare. In this report the author ... Full text Link to item Cite

Systemic CTLA-4 blockade ameliorates glioma-induced changes to the CD4+ T cell compartment without affecting regulatory T-cell function.

Journal Article Clin Cancer Res · April 1, 2007 PURPOSE: Patients with malignant glioma suffer global compromise of their cellular immunity, characterized by dramatic reductions in CD4(+) T cell numbers and function. We have previously shown that increased regulatory T cell (T(reg)) fractions in these p ... Full text Link to item Cite

Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity.

Journal Article J Neuroimmunol · January 2007 For the study of malignant glioma, we have previously characterized a highly tumorigenic murine astrocytoma, SMA-560, which arose spontaneously in an inbred, immunocompetent VM/Dk mouse. Using this cell line as a model of murine glioma, we performed DNA mi ... Full text Link to item Cite

Ventriculoperitoneal shunt failure causing myelopathy in a patient with bilateral jugular vein occlusion. Case report.

Journal Article J Neurosurg Spine · January 2007 The authors describe the case of a 36-year-old woman with bilateral internal jugular vein occlusion, hydrocephalus, and Dandy-Walker variant who presented with myelopathy that was ultimately attributed to ventriculoperitoneal (VP) shunt failure. Computed t ... Full text Link to item Cite

Systemic anti-CD25 monoclonal antibody administration safely enhances immunity in murine glioma without eliminating regulatory T cells.

Journal Article Clin Cancer Res · July 15, 2006 PURPOSE: Elevated proportions of regulatory T cells (T(reg)) are present in patients with a variety of cancers, including malignant glioma, yet recapitulative murine models are wanting. We therefore examined T(regs) in mice bearing malignant glioma and eva ... Full text Link to item Cite

Systemic hemostasis with recombinant-activated factor VII followed by local thrombolysis with recombinant tissue plasminogen activator in intraventricular hemorrhage.

Journal Article Neurocrit Care · 2005 INTRODUCTION: A 51-year-old woman on warfarin thromboprophylaxis for transient ischemic attacks developed sudden onset nausea, vomiting, and decreased mental status, rapidly becoming comatose. Head computed tomography (CT) showed intracerebral hemorrhage, ... Full text Link to item Cite

Microvascular decompression for glossopharyngeal neuralgia: long-term effectiveness and complication avoidance.

Journal Article Neurosurgery · April 2004 OBJECTIVE: To establish the long-term safety, efficacy, and durability of microvascular decompression (MVD) for the treatment of glossopharyngeal neuralgia, this study presents the immediate (<6 mo) postoperative and long-term results of a large series of ... Full text Link to item Cite

Immunotherapy of surgical malignancies.

Journal Article Curr Probl Surg · January 2004 Full text Link to item Cite

Efficacy of intracerebral microinfusion of trastuzumab in an athymic rat model of intracerebral metastatic breast cancer.

Journal Article Clin Cancer Res · November 15, 2003 PURPOSE: The monoclonal antibody (MAb) trastuzumab (Herceptin) effectively treats HER2-overexpressing extracerebral breast neoplasms. Delivery of such macromolecule therapeutic agents to intracerebral metastases, however, is limited by the tight junctions ... Link to item Cite

Extradural thoracic arteriovenous malformation in a patient with Klippel-Trenaunay-Weber syndrome: case report.

Journal Article Neurosurgery · November 2002 OBJECTIVE AND IMPORTANCE: Spinal cord involvement in Klippel-Trenaunay-Weber (KTW) syndrome is rare. Cases of intradural spinal cord arteriovenous malformations (AVMs) have been associated with this syndrome. Likewise, cases of epidural hemangioma and angi ... Full text Link to item Cite