Current Appointments & Affiliations
Assistant Professor of Biomedical Engineering
·
2024 - Present
Biomedical Engineering,
Pratt School of Engineering
Recent Publications
Droplet microfluidic screening to engineer angiotensin-converting enzyme 2 (ACE2) catalytic activity.
Journal Article Journal of biological engineering · February 2025 BackgroundAngiotensin-Converting Enzyme 2 (ACE2) is a crucial peptidase in human peptide hormone signaling, catalyzing the conversion of Angiotensin-II to Angiotensin-(1-7), which activates the Mas receptor and elicits vasodilation, increased bloo ... Full text CiteDroplet microfluidic screening to engineer angiotensin-converting enzyme 2 (ACE2) catalytic activity
Preprint · October 5, 2024 Full text CiteNeural network extrapolation to distant regions of the protein fitness landscape.
Journal Article Nature communications · July 2024 Machine learning (ML) has transformed protein engineering by constructing models of the underlying sequence-function landscape to accelerate the discovery of new biomolecules. ML-guided protein design requires models, trained on local sequence-function inf ... Full text CiteRecent Grants
Application of Machine Learning to Design of Catalysts with Improved Properties and Development of AI Model to Generate Protein Sequences with Tailored Properties
ResearchPrincipal Investigator · Awarded by Boehringer Ingelheim Pharmaceuticals, Inc. · 2024 - 2028Structure-Guided Protein Recombination to Develop Single Species Elimination Bacteriophage Endolysins for Microbiome Modulation
ResearchPrincipal Investigator · Awarded by Army Research Office · 2024 - 2027Generative AI-Based Design of Novel Silicase Enzymes for Carbon-Sequestering Agriculture
ResearchPrincipal Investigator · Awarded by Homeworld Collective · 2024 - 2025View All Grants
Education, Training & Certifications
California Institute of Technology ·
2012
Ph.D.