Current Appointments & Affiliations
Associate Professor of Biomedical Engineering
·
2025 - Present
Biomedical Engineering,
Pratt School of Engineering
Recent Publications
Biophysics-based protein language models for protein engineering.
Journal Article Nature methods · September 2025 Protein language models trained on evolutionary data have emerged as powerful tools for predictive problems involving protein sequence, structure and function. However, these models overlook decades of research into biophysical factors governing protein fu ... Full text CiteDroplet microfluidic screening to engineer angiotensin-converting enzyme 2 (ACE2) catalytic activity.
Journal Article Journal of biological engineering · February 2025 BackgroundAngiotensin-Converting Enzyme 2 (ACE2) is a crucial peptidase in human peptide hormone signaling, catalyzing the conversion of Angiotensin-II to Angiotensin-(1-7), which activates the Mas receptor and elicits vasodilation, increased bloo ... Full text CiteRecent Grants
Application of Machine Learning to Design of Catalysts with Improved Properties and Development of AI Model to Generate Protein Sequences with Tailored Properties
ResearchPrincipal Investigator · Awarded by Boehringer Ingelheim Pharmaceuticals, Inc. · 2024 - 2028Structure-Guided Protein Recombination to Develop Single Species Elimination Bacteriophage Endolysins for Microbiome Modulation
ResearchPrincipal Investigator · Awarded by Army Research Office · 2024 - 2027Self-driving laboratories for autonomous exploration of protein sequence space
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2027View All Grants
Education, Training & Certifications
California Institute of Technology ·
2012
Ph.D.