Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow in Cardiology, Medicine, Duke University 1998 - 2004
  • Medical Resident, Medicine, Duke University 1995 - 1998
  • M.D., Harvard University 1995
• 

  Duke Appointment History

  • Assistant Professor of Medicine, Medicine, Cardiology, Medicine 2004 - 2014
  • Instructor, Temporary in the Department of Medicine, Medicine, Cardiology, Medicine 2004
• Research
• 

  Selected Grants

  • ALLSTAR awarded by Capricor Therapeutics, Inc. 2014 - 2021
  • DREAM-HF awarded by Mesoblast International Sarl 2014 - 2020
  • ATHENA awarded by Cytori Therapeutics, Inc. 2013 - 2020
  • A Randomized, Double-Blind, Placebo-Controlled, Safety and Tolerability Study of Escalating Single Doses of ITI-214 in Patients with Systolic Heart Failure awarded by Intra-Cellular Therapies, Inc. 2017 - 2020
  • A Biomarker Study of the APEX-AMI and SOLSTICE Trial Populations awarded by GlaxoSmithKline 2016 - 2018
  • Aptamer-based affinity capture of circulating CAD EPCs awarded by National Institutes of Health 2013 - 2016
  • ATHENA II awarded by Cytori Therapeutics, Inc. 2014 - 2016
  • EPC Adhesion to Teflon-AF and ePTFE Vascular Grafts awarded by National Institutes of Health 1990 - 2013
  • REVEAL (Reduction of Infarct Expansion and Ventricular remodeling with Epo Administration after Large MI) awarded by National Institutes of Health 2005 - 2011
  • Assessing Circulating Progenitor Cells in Heart Disease awarded by National Institutes of Health 2006 - 2008
  • Blood pressure, endothelial cell dysfunction and outcomes in kidney disease awarded by National Institutes of Health 2008
• Publications & Artistic Works
• 

  Selected Publications

  • Book Sections

    • Povsic, TJ. "Mesenchymal Stem Cells for Treatment of Peripheral Vascular Disease." In Regenerative Medicine for Peripheral Artery Disease, 43-70. June 13, 2016.  Full Text

  • Journal Articles

    • Henry, TD, Losordo, DW, Traverse, JH, Schatz, RA, Jolicoeur, EM, Schaer, GL, Clare, R, Chiswell, K, White, CJ, Fortuin, FD, Kereiakes, DJ, Zeiher, AM, Sherman, W, Hunt, AS, and Povsic, TJ. "Autologous CD34+ cell therapy improves exercise capacity, angina frequency and reduces mortality in no-option refractory angina: a patient-level pooled analysis of randomized double-blinded trials." European Heart Journal 39, no. 23 (June 2018): 2208-2216.  Full Text
    • Brilakis, ES, Edson, R, Bhatt, DL, Goldman, S, Holmes, DR, Rao, SV, Shunk, K, Rangan, BV, Mavromatis, K, Ramanathan, K, Bavry, AA, Garcia, S, Latif, F, Armstrong, E, Jneid, H, Conner, TA, Wagner, T, Karacsonyi, J, Uyeda, L, Ventura, B, Alsleben, A, Lu, Y, Shih, M-C, Banerjee, S, and DIVA Trial Investigators, . "Drug-eluting stents versus bare-metal stents in saphenous vein grafts: a double-blind, randomised trial." Lancet (London, England) 391, no. 10134 (May 11, 2018): 1997-2007.  Full Text
    • Povsic, TJ. "Approaching Regulatory Approval of Cardiovascular Regenerative Therapy." Circulation research 122, no. 4 (February 2018): 552-554.  Full Text
    • Henry, TD, Povsic, TJ, and Losordo, DW. "The (Translational) Road Less Traveled." Circulation Research 122, no. 2 (January 2018): 207-209.  Full Text
    • Povsic, TJ. "Emerging Therapies for Congestive Heart Failure." Clinical pharmacology and therapeutics 103, no. 1 (January 2018): 77-87. (Review)  Full Text
    • Chung, MJ, Hansen, JD, Schulteis, RD, Boggan, JC, Jones, WS, Povsic, TJ, Roberts, S, Krucoff, MW, and Rao, SV. "Understanding operator stent choice in the catheterization laboratory using a pre-procedure survey: Opportunities for quality improvement." Cardiovascular Revascularization Medicine : Including Molecular Interventions 18, no. 8 (December 2017): 588-591.  Full Text  Open Access Copy
    • Teerlink, JR, Metra, M, Filippatos, GS, Davison, BA, Bartunek, J, Terzic, A, Gersh, BJ, Povsic, TJ, Henry, TD, Alexandre, B, Homsy, C, Edwards, C, Seron, A, Wijns, W, Cotter, G, and CHART Investigators, . "Benefit of cardiopoietic mesenchymal stem cell therapy on left ventricular remodelling: results from the Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) study." European Journal of Heart Failure 19, no. 11 (November 2017): 1520-1529.  Full Text
    • Fernández-Avilés, F, Sanz-Ruiz, R, Climent, AM, Badimon, L, Bolli, R, Charron, D, Fuster, V, Janssens, S, Kastrup, J, Kim, H-S, Lüscher, TF, Martin, JF, Menasché, P, Simari, RD, Stone, GW, Terzic, A, Willerson, JT, Wu, JC, Broughton, K, DiFede, DL, Dimmeler, S, Madonna, R, Penn, MS, Sussman, MA, Sluijter, JPG, Wollert, KC, Balkan, W, Chamuleau, S, Fernández-Santos, ME, Goliasch, G, Gyöngyösi, M, Hare, JM, Tompkins, BA, Winkler, J, Bayés-Genís, A, Henry, TD, Taylor, DA, Lerman, A, Pelacho, B, Prosper, F, Perin, EC, Pompilio, G, Gersh, B, Bartunek, J, Duckers, E, Ferdinandy, P, Losordo, DW, Sánchez, PL, Sherman, W, Wojakowski, W, Zeiher, A, Roncalli, J, Mathur, A, Crea, F, D´Amario, D, Povsic, TJ, Traverse, J, and Ylä-Herttuala, S. "Global position paper on cardiovascular regenerative medicine." European Heart Journal 38, no. 33 (September 1, 2017): 2532-2546.  Full Text
    • Povsic, TJ, Scott, R, Mahaffey, KW, Blaustein, R, Edelberg, JM, Lefkowitz, MP, Solomon, SD, Fox, JC, Healy, KE, Khakoo, AY, Losordo, DW, Malik, FI, Monia, BP, Montgomery, RL, Riesmeyer, J, Schwartz, GG, Zelenkofske, SL, Wu, JC, Wasserman, SM, and Roe, MT. "Navigating the Future of Cardiovascular Drug Development-Leveraging Novel Approaches to Drive Innovation and Drug Discovery: Summary of Findings from the Novel Cardiovascular Therapeutics Conference." Cardiovascular Drugs and Therapy 31, no. 4 (August 2017): 445-458. (Review)  Full Text
    • Ohman, EM, Roe, MT, Steg, PG, James, SK, Povsic, TJ, White, J, Rockhold, F, Plotnikov, A, Mundl, H, Strony, J, Sun, X, Husted, S, Tendera, M, Montalescot, G, Bahit, MC, Ardissino, D, Bueno, H, Claeys, MJ, Nicolau, JC, Cornel, JH, Goto, S, Kiss, RG, Güray, Ü, Park, D-W, Bode, C, Welsh, RC, and Gibson, CM. "Clinically significant bleeding with low-dose rivaroxaban versus aspirin, in addition to P2Y12 inhibition, in acute coronary syndromes (GEMINI-ACS-1): a double-blind, multicentre, randomised trial." Lancet (London, England) 389, no. 10081 (May 2017): 1799-1808.  Full Text  Open Access Copy
    • Bartunek, J, Terzic, A, Davison, BA, Filippatos, GS, Radovanovic, S, Beleslin, B, Merkely, B, Musialek, P, Wojakowski, W, Andreka, P, Horvath, IG, Katz, A, Dolatabadi, D, El Nakadi, B, Arandjelovic, A, Edes, I, Seferovic, PM, Obradovic, S, Vanderheyden, M, Jagic, N, Petrov, I, Atar, S, Halabi, M, Gelev, VL, Shochat, MK, Kasprzak, JD, Sanz-Ruiz, R, Heyndrickx, GR, Nyolczas, N, Legrand, V, Guédès, A, Heyse, A, Moccetti, T, Fernandez-Aviles, F, Jimenez-Quevedo, P, Bayes-Genis, A, Hernandez-Garcia, JM, Ribichini, F, Gruchala, M, Waldman, SA, Teerlink, JR, Gersh, BJ, Povsic, TJ, Henry, TD, Metra, M, Hajjar, RJ, Tendera, M, Behfar, A, Alexandre, B, Seron, A, Stough, WG, Sherman, W, Cotter, G, Wijns, W, and CHART Program, . "Cardiopoietic cell therapy for advanced ischaemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial." European Heart Journal 38, no. 9 (March 2017): 648-660.  Full Text
    • Chakravarty, T, Makkar, RR, Ascheim, DD, Traverse, JH, Schatz, R, DeMaria, A, Francis, GS, Povsic, TJ, Smith, RR, Lima, JA, Pogoda, JM, Marbán, L, and Henry, TD. "ALLogeneic Heart STem Cells to Achieve Myocardial Regeneration (ALLSTAR) Trial: Rationale and Design." Cell Transplantation 26, no. 2 (February 2017): 205-214.  Full Text
    • Henry, TD, Pepine, CJ, Lambert, CR, Traverse, JH, Schatz, R, Costa, M, Povsic, TJ, David Anderson, R, Willerson, JT, Kesten, S, and Perin, EC. "The Athena trials: Autologous adipose-derived regenerative cells for refractory chronic myocardial ischemia with left ventricular dysfunction." Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions 89, no. 2 (February 2017): 169-177.  Full Text
    • Welsh, RC, Roe, MT, Steg, PG, James, S, Povsic, TJ, Bode, C, Gibson, CM, and Ohman, EM. "Corrigendum to "A critical reappraisal of aspirin for secondary prevention in patients with ischemic heart disease" [Am Heart J 181 (2016) 92-100]." American Heart Journal 184 (February 2017): 156-null.  Full Text
    • Povsic, TJ, Lawrence, MG, Lincoff, AM, Mehran, R, Rusconi, CP, Zelenkofske, SL, Huang, Z, Sailstad, J, Armstrong, PW, Steg, PG, Bode, C, Becker, RC, Alexander, JH, Adkinson, NF, Levinson, AI, and REGULATE-PCI Investigators, . "Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer." The Journal of Allergy and Clinical Immunology 138, no. 6 (December 2016): 1712-1715. (Letter)  Full Text
    • Welsh, RC, Roe, MT, Steg, PG, James, S, Povsic, TJ, Bode, C, Gibson, CM, and Ohman, EM. "A critical reappraisal of aspirin for secondary prevention in patients with ischemic heart disease." American Heart Journal 181 (November 2016): 92-100. (Review)  Full Text
    • Povsic, TJ, Henry, TD, Traverse, JH, Fortuin, FD, Schaer, GL, Kereiakes, DJ, Schatz, RA, Zeiher, AM, White, CJ, Stewart, DJ, Jolicoeur, EM, Bass, T, Henderson, DA, Dignacco, P, Gu, Z, Al-Khalidi, HR, Junge, C, Nada, A, Hunt, AS, Losordo, DW, and RENEW Investigators, . "The RENEW Trial: Efficacy and Safety of Intramyocardial Autologous CD34(+) Cell Administration in Patients With Refractory Angina." Jacc. Cardiovascular Interventions 9, no. 15 (August 2016): 1576-1585.  Full Text
    • Nimjee, SM, Povsic, TJ, Sullenger, BA, and Becker, RC. "Translation and Clinical Development of Antithrombotic Aptamers." Nucleic acid therapeutics 26, no. 3 (June 2016): 147-155. (Review)  Full Text
    • Povsic, TJ, and Losordo, DW. "Getting Back to Normal: Can Enhanced Regeneration Maintain Health?." Circulation research 118, no. 12 (June 2016): 1863-1865.  Full Text
    • Povsic, TJ, and Zeiher, AM. "IxCELL-DCM: rejuvenation for cardiac regenerative therapy?." Lancet (London, England) 387, no. 10036 (June 2016): 2362-2363.  Full Text
    • Ganson, NJ, Povsic, TJ, Sullenger, BA, Alexander, JH, Zelenkofske, SL, Sailstad, JM, Rusconi, CP, and Hershfield, MS. "Pre-existing anti-polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer." The Journal of Allergy and Clinical Immunology 137, no. 5 (May 2016): 1610-1613.e7. (Letter)  Full Text
    • Povsic, TJ, Roe, MT, Ohman, EM, Steg, PG, James, S, Plotnikov, A, Mundl, H, Welsh, R, Bode, C, and Gibson, CM. "A randomized trial to compare the safety of rivaroxaban vs aspirin in addition to either clopidogrel or ticagrelor in acute coronary syndrome: The design of the GEMINI-ACS-1 phase II study." American Heart Journal 174 (April 2016): 120-128.  Full Text
    • "Department of Error." The Lancet 387, no. 10024 (March 2016): 1162-1162.  Full Text
    • Povsic, TJ, Sloane, R, Pieper, CF, Pearson, MP, Peterson, ED, Cohen, HJ, and Morey, MC. "Endothelial Progenitor Cell Levels Predict Future Physical Function: An Exploratory Analysis From the VA Enhanced Fitness Study." The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 71, no. 3 (March 2016): 362-369.  Full Text
    • Fernandez, CE, Yen, RW, Perez, SM, Bedell, HW, Povsic, TJ, Reichert, WM, and Truskey, GA. "Human Vascular Microphysiological System for in vitro Drug Screening." Scientific Reports 6 (February 18, 2016): 21579-null.  Full Text  Open Access Copy
    • Bartunek, J, Davison, B, Sherman, W, Povsic, T, Henry, TD, Gersh, B, Metra, M, Filippatos, G, Hajjar, R, Behfar, A, Homsy, C, Cotter, G, Wijns, W, Tendera, M, and Terzic, A. "Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial design." European Journal of Heart Failure 18, no. 2 (February 2016): 160-168.  Full Text
    • Povsic, TJ. "Current State of Stem Cell Therapy for Ischemic Heart Disease." Current Cardiology Reports 18, no. 2 (February 2016): 17-null. (Review)  Full Text
    • Henry, TD, Schaer, GL, Traverse, JH, Povsic, TJ, Davidson, C, Lee, JS, Costa, MA, Bass, T, Mendelsohn, F, Fortuin, FD, Pepine, CJ, Patel, AN, Riedel, N, Junge, C, Hunt, A, Kereiakes, DJ, White, C, Harrington, RA, Schatz, RA, Losordo, DW, and ACT, . "Autologous CD34+ Cell Therapy for Refractory Angina: 2-Year Outcomes From the ACT34-CMI Study." Cell Transplantation 25, no. 9 (January 2016): 1701-1711.  Full Text
    • Lincoff, AM, Mehran, R, Povsic, TJ, Zelenkofske, SL, Huang, Z, Armstrong, PW, Steg, PG, Bode, C, Cohen, MG, Buller, C, Laanmets, P, Valgimigli, M, Marandi, T, Fridrich, V, Cantor, WJ, Merkely, B, Lopez-Sendon, J, Cornel, JH, Kasprzak, JD, Aschermann, M, Guetta, V, Morais, J, Sinnaeve, PR, Huber, K, Stables, R, Sellers, MA, Borgman, M, Glenn, L, Levinson, AI, Lopes, RD, Hasselblad, V, Becker, RC, Alexander, JH, and REGULATE-PCI Investigators, . "Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial." Lancet (London, England) 387, no. 10016 (January 2016): 349-356.  Full Text
    • Henry, TD, and Povsic, TJ. "Repeat Cell Therapy for Refractory Angina: Déjà vu All Over Again?." Circulation. Cardiovascular interventions 8, no. 8 (August 2015).  Full Text
    • Patel, MR, Conte, MS, Cutlip, DE, Dib, N, Geraghty, P, Gray, W, Hiatt, WR, Ho, M, Ikeda, K, Ikeno, F, Jaff, MR, Jones, WS, Kawahara, M, Lookstein, RA, Mehran, R, Misra, S, Norgren, L, Olin, JW, Povsic, TJ, Rosenfield, K, Rundback, J, Shamoun, F, Tcheng, J, Tsai, TT, Suzuki, Y, Vranckx, P, Wiechmann, BN, White, CJ, Yokoi, H, and Krucoff, MW. "Evaluation and treatment of patients with lower extremity peripheral artery disease: consensus definitions from Peripheral Academic Research Consortium (PARC)." Journal of the American College of Cardiology 65, no. 9 (March 2015): 931-941.  Full Text
    • Povsic, TJ, Broderick, S, Anstrom, KJ, Shaw, LK, Ohman, EM, Eisenstein, EL, Smith, PK, and Alexander, JH. "Predictors of long-term clinical endpoints in patients with refractory angina." Journal of the American Heart Association 4, no. 2 (February 2015).  Full Text
    • Patel, MR, Conte, MS, Cutlip, DE, Dib, N, Geraghty, P, Gray, W, Hiatt, WR, Ho, M, Ikeda, K, Ikeno, F, Jaff, MR, Jones, WS, Kawahara, M, Lookstein, RA, Mehran, R, Misra, S, Norgren, L, Olin, JW, Povsic, TJ, Rosenfield, K, Rundback, J, Shamoun, F, Tcheng, J, Tsai, TT, Suzuki, Y, Vranckx, P, Wiechmann, BN, White, CJ, Yokoi, H, and Krucoff, MW. "Erratum: Evaluation and treatment of patients with lower extremity peripheral artery disease: Consensus definitions from Peripheral Academic Research Consortium (PARC) (Journal of the American College of Cardiology (2015) 65:(931-41))." Journal of the American College of Cardiology 65, no. 23 (January 1, 2015): 2578-2579.  Full Text
    • Granger, CB, and Povsic, TJ. "Another biomarker for risk assessment in acute myocardial infarction?." Journal of the American College of Cardiology 64, no. 16 (October 2014): 1708-1710.  Full Text
    • Vavalle, JP, Rusconi, CP, Zelenkofske, S, Wargin, WA, Ortel, TL, Alexander, JH, Povsic, TJ, and Becker, RC. "The effect of the REG2 Anticoagulation System on thrombin generation kinetics: a pharmacodynamic and pharmacokinetic first-in-human study." Journal of thrombosis and thrombolysis 38, no. 3 (October 2014): 275-284.  Full Text
    • Povsic, TJ, Vavalle, JP, Alexander, JH, Aberle, LH, Zelenkofske, SL, Becker, RC, Buller, CE, Cohen, MG, Cornel, JH, Kasprzak, JD, Montalescot, G, Fail, PS, Sarembock, IJ, Mehran, R, and RADAR Investigators, . "Use of the REG1 anticoagulation system in patients with acute coronary syndromes undergoing percutaneous coronary intervention: results from the phase II RADAR-PCI study." EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 10, no. 4 (August 2014): 431-438.  Full Text
    • Povsic, TJ, Vavalle, JP, Alexander, JH, Aberle, LH, Zelenkofske, SL, Becker, RC, Buller, CE, Cohen, MG, Cornel, JH, Kasprzak, JD, Montalescot, G, Fail, PS, Sarembock, IJ, and Mehran, R. "Use of the REG1 anticoagulation system in patients with acute coronary syndromes undergoing percutaneous coronary intervention: Results from the phase II RADAR-PCI study." Eurointervention 10, no. 4 (August 1, 2014): 431-438.  Full Text
    • Al-Khatib, SM, Allen LaPointe, NM, Chatterjee, R, Crowley, MJ, Dupre, ME, Kong, DF, Lopes, RD, Povsic, TJ, Raju, SS, Shah, B, Kosinski, AS, McBroom, AJ, and Sanders, GD. "Rate- and rhythm-control therapies in patients with atrial fibrillation: a systematic review." Annals of Internal Medicine 160, no. 11 (June 2014): 760-773. (Review)  Full Text
    • Vavalle, JP, Rusconi, CP, Zelenkofske, S, Wargin, WA, Ortel, TL, Alexander, JH, Povsic, TJ, and Becker, RC. "The effect of the REG2 Anticoagulation System on thrombin generation kinetics: A pharmacodynamic and pharmacokinetic first-in-human study." Journal of Thrombosis and Thrombolysis 38, no. 3 (January 1, 2014): 275-284.  Full Text
    • Becker, RC, Chan, MY, Vavalle, JP, and Povsic, TJ. "Anticoagulation and monitoring of a novel and reversible factor IXa inhibitor." Drug Development Research 74, no. 8 (December 1, 2013): 510-516. (Review)  Full Text
    • Povsic, TJ, Sloane, R, Zhou, J, Pieper, CF, Pearson, MP, Peterson, ED, Green, JB, Cohen, HJ, and Morey, MC. "Lower levels of circulating progenitor cells are associated with low physical function and performance in elderly men with impaired glucose tolerance: a pilot substudy from the VA Enhanced Fitness trial." J Gerontol A Biol Sci Med Sci 68, no. 12 (December 2013): 1559-1566.  Full Text  Link to Item
    • Povsic, TJ, Najjar, SS, Prather, K, Zhou, J, Adams, SD, Zavodni, KL, Kelly, F, Melton, LG, Hasselblad, V, Heitner, JF, Raman, SV, Barsness, GW, Patel, MR, Kim, RJ, Lakatta, EG, Harrington, RA, and Rao, SV. "EPC mobilization after erythropoietin treatment in acute ST-elevation myocardial infarction: The REVEAL EPC substudy." Journal of Thrombosis and Thrombolysis 36, no. 4 (November 1, 2013): 375-383.  Full Text
    • Povsic, TJ, Najjar, SS, Prather, K, Zhou, J, Adams, SD, Zavodni, KL, Kelly, F, Melton, LG, Hasselblad, V, Heitner, JF, Raman, SV, Barsness, GW, Patel, MR, Kim, RJ, Lakatta, EG, Harrington, RA, and Rao, SV. "EPC mobilization after erythropoietin treatment in acute ST-elevation myocardial infarction: the REVEAL EPC substudy." J Thromb Thrombolysis 36, no. 4 (November 2013): 375-383.  Full Text  Link to Item
    • Povsic, TJ, Sloane, R, Green, JB, Zhou, J, Pieper, CF, Pearson, MP, Peterson, ED, Cohen, HJ, and Morey, MC. "Depletion of circulating progenitor cells precedes overt diabetes: A substudy from the VA enhanced fitness trial." Journal of Diabetes and its Complications 27, no. 6 (November 1, 2013): 633-636.  Full Text
    • Vavalle, JP, Povsic, TJ, Aberle, LH, Zelenkofske, SL, Mehran, R, Kasprzak, JD, Bode, C, Buller, CE, Montalescot, G, Cornel, JH, Becker, RC, Alexander, JH, and Cohen, MG. "Safety of very early sheath removal in patients treated with REG1 for acute coronary syndromes: insights from the RADAR trial." J Invasive Cardiol 25, no. 11 (November 2013): 593-599.  Link to Item
    • Jones, LW, Fels, DR, West, M, Allen, JD, Broadwater, G, Barry, WT, Wilke, LG, Masko, E, Douglas, PS, Dash, RC, Povsic, TJ, Peppercorn, J, Marcom, PK, Blackwell, KL, Kimmick, G, Turkington, TG, and Dewhirst, MW. "Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy." Cancer Prevention Research (Philadelphia, Pa.) 6, no. 9 (September 2013): 925-937.  Full Text
    • Povsic, TJ, Vavalle, JP, Aberle, LH, Kasprzak, JD, Cohen, MG, Mehran, R, Bode, C, Buller, CE, Montalescot, G, Cornel, JH, Rynkiewicz, A, Ring, ME, Zeymer, U, Natarajan, M, Delarche, N, Zelenkofske, SL, Becker, RC, Alexander, JH, and RADAR Investigators, . "A Phase 2, randomized, partially blinded, active-controlled study assessing the efficacy and safety of variable anticoagulation reversal using the REG1 system in patients with acute coronary syndromes: results of the RADAR trial." Eur Heart J 34, no. 31 (August 2013): 2481-2489.  Full Text  Link to Item
    • Povsic, TJ, Junge, C, Nada, A, Schatz, RA, Harrington, RA, Davidson, CJ, Fortuin, FD, Kereiakes, DJ, Mendelsohn, FO, Sherman, W, Schaer, GL, White, CJ, Stewart, D, Story, K, Losordo, DW, and Henry, TD. "A phase 3, randomized, double-blinded, active-controlled, unblinded standard of care study assessing the efficacy and safety of intramyocardial autologous CD34+ cell administration in patients with refractory angina: design of the RENEW study." American Heart Journal 165, no. 6 (June 2013): 854-861.e2.  Full Text
    • Becker, RC, Chan, MY, Vavalle, JP, and Povsic, TJ. "Anticoagulation and Monitoring of a Novel and Reversible Factor IXa Inhibitor." Drug Development Research (2013).
    • Povsic, TJ, Junge, C, Nada, A, Schatz, RA, Harrington, RA, Davidson, CJ, Fortuin, FD, Kereiakes, DJ, Mendelsohn, FO, Sherman, W, Schaer, GL, White, CJ, Stewart, D, Story, K, Losordo, DW, and Henry, TD. "A phase 3, randomized, double-blinded, active-controlled, unblinded standard of care study assessing the efficacy and safety of intramyocardial autologous cd34+ cell administration in patients with refractory angina: Design of the renew study." American Heart Journal 165, no. 6 (2013): 854-861.e2.  Full Text
    • Say, EAT, Melamud, A, Esserman, DA, Povsic, TJ, and Chavala, SH. "Comparative analysis of circulating endothelial progenitor cells in age-related macular degeneration patients using automated rare cell analysis (ARCA) and fluorescence activated cell sorting (FACS)." PLoS One 8, no. 1 (2013): e55079-.  Full Text  Link to Item
    • Povsic, TJ, Losordo, DW, Story, K, Junge, CE, Schatz, RA, Harrington, RA, and Henry, TD. "Incidence and clinical significance of cardiac biomarker elevation during stem cell mobilization, apheresis, and intramyocardial delivery: an analysis from ACT34-CMI." Am Heart J 164, no. 5 (November 2012): 689-697.e3.  Full Text  Link to Item
    • Inrig, JK, Van Buren, P, Kim, C, Vongpatanasin, W, Povsic, TJ, and Toto, R. "Probing the mechanisms of intradialytic hypertension: a pilot study targeting endothelial cell dysfunction." Clin J Am Soc Nephrol 7, no. 8 (August 2012): 1300-1309.  Full Text  Link to Item
    • Povsic, TJ, O'Connor, CM, Henry, T, Taussig, A, Kereiakes, DJ, Fortuin, FD, Niederman, A, Schatz, R, Spencer, R, Owens, D, Banks, M, Joseph, D, Roberts, R, Alexander, JH, and Sherman, W. "A double-blind, randomized, controlled, multicenter study to assess the safety and cardiovascular effects of skeletal myoblast implantation by catheter delivery in patients with chronic heart failure after myocardial infarction." American Heart Journal 162, no. 4 (October 2011): 654-662.e1.  Full Text
    • Povsic, TJ, Wargin, WA, Alexander, JH, Krasnow, J, Krolick, M, Cohen, MG, Mehran, R, Buller, CE, Bode, C, Zelenkofske, SL, Rusconi, CP, Becker, RC, and RADAR Investigators, . "Pegnivacogin results in near complete FIX inhibition in acute coronary syndrome patients: RADAR pharmacokinetic and pharmacodynamic substudy." Eur Heart J 32, no. 19 (October 2011): 2412-2419.  Full Text  Link to Item
    • Inrig, JK, Van Buren, P, Kim, C, Vongpatanasin, W, Povsic, TJ, and Toto, RD. "Intradialytic hypertension and its association with endothelial cell dysfunction." Clinical Journal of the American Society of Nephrology : Cjasn 6, no. 8 (August 2011): 2016-2024.  Full Text
    • Losordo, DW, Henry, TD, Davidson, C, Sup Lee, J, Costa, MA, Bass, T, Mendelsohn, F, Fortuin, FD, Pepine, CJ, Traverse, JH, Amrani, D, Ewenstein, BM, Riedel, N, Story, K, Barker, K, Povsic, TJ, Harrington, RA, Schatz, RA, and ACT34-CMI Investigators, . "Intramyocardial, autologous CD34+ cell therapy for refractory angina." Circulation Research 109, no. 4 (August 2011): 428-436.  Full Text
    • Povsic, TJ, Cohen, MG, Chan, MY, Zelenkofske, SL, Wargin, WA, Harrington, RA, Alexander, JH, Rusconi, CP, and Becker, RC. "Dose selection for a direct and selective factor IXa inhibitor and its complementary reversal agent: translating pharmacokinetic and pharmacodynamic properties of the REG1 system to clinical trial design." J Thromb Thrombolysis 32, no. 1 (July 2011): 21-31.  Full Text  Link to Item
    • Najjar, SS, Rao, SV, Melloni, C, Raman, SV, Povsic, TJ, Melton, L, Barsness, GW, Prather, K, Heitner, JF, Kilaru, R, Gruberg, L, Hasselblad, V, Greenbaum, AB, Patel, M, Kim, RJ, Talan, M, Ferrucci, L, Longo, DL, Lakatta, EG, Harrington, RA, and REVEAL Investigators, . "Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial." JAMA 305, no. 18 (May 11, 2011): 1863-1872.  Full Text  Link to Item
    • Povsic, TJ, Cohen, MG, Mehran, R, Buller, CE, Bode, C, Cornel, JH, Kasprzak, JD, Montalescot, G, Joseph, D, Wargin, WA, Rusconi, CP, Zelenkofske, SL, Becker, RC, and Alexander, JH. "A randomized, partially blinded, multicenter, active-controlled, dose-ranging study assessing the safety, efficacy, and pharmacodynamics of the REG1 anticoagulation system in patients with acute coronary syndromes: design and rationale of the RADAR Phase IIb trial." Am Heart J 161, no. 2 (February 2011): 261-268.e1-2-.  Full Text  Link to Item
    • Povsic, TJ, Cohen, MG, Chan, MY, Zelenkofske, SL, Wargin, WA, Harrington, RA, Alexander, JH, Rusconi, CP, and Becker, RC. "Dose Selection for a Direct and Selective Factor IXa Inhibitor and its Complementary Reversal Agent: Translating Pharmacokinetic and Pharmacodynamic Properties of the REG1 System to Clinical Trial Design." Journal of Thrombosis and Thrombolysis (2011): 1-11.  Full Text
    • Povsic, TJ, Sullenger, BA, Zelenkofske, SL, Rusconi, CP, and Becker, RC. "Translating nucleic acid aptamers to antithrombotic drugs in cardiovascular medicine." J Cardiovasc Transl Res 3, no. 6 (December 2010): 704-716. (Review)  Full Text  Link to Item
    • Melloni, C, Rao, SV, Povsic, TJ, Melton, L, Kim, RJ, Kilaru, R, Patel, MR, Talan, M, Ferrucci, L, Longo, DL, Lakatta, EG, Najjar, SS, and Harrington, RA. "Design and rationale of the Reduction of Infarct Expansion and Ventricular Remodeling with Erythropoietin after Large Myocardial Infarction (REVEAL) trial." Am Heart J 160, no. 5 (November 2010): 795-803.e2.  Full Text  Link to Item
    • Povsic, TJ, Zhou, J, Adams, SD, Bolognesi, MP, Attarian, DE, and Peterson, ED. "Aging is not associated with bone marrow-resident progenitor cell depletion." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 65, no. 10 (October 2010): 1042-1050.  Full Text
    • Lou, J, Povsic, TJ, Allen, JD, Adams, SD, Myles, S, Starr, AZ, Ortel, TL, and Becker, RC. "The effect of aspirin on endothelial progenitor cell biology: preliminary investigation of novel properties." Thromb Res 126, no. 3 (September 2010): e175-e179.  Full Text  Link to Item
    • Povsic, TJ, and O'Connor, CM. "Cell therapy for heart failure: the need for a new therapeutic strategy." Expert Rev Cardiovasc Ther 8, no. 8 (August 2010): 1107-1126. (Review)  Full Text  Link to Item
    • Becker, RC, Povsic, T, Cohen, MG, Rusconi, CP, and Sullenger, B. "Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics." Thromb Haemost 103, no. 3 (March 2010): 586-595. (Review)  Full Text  Link to Item
    • Povsic, TJ, Sullenger, BA, Zelenkofske, SL, Rusconi, CP, and Becker, RC. "Translating Nucleic Acid Aptamers to Antithrombotic Drugs in Cardiovascular Medicine." Journal of Cardiovascular Translational Research (2010): 1-13.  Full Text
    • Stroncek, JD, Grant, BS, Brown, MA, Povsic, TJ, Truskey, GA, and Reichert, WM. "Comparison of endothelial cell phenotypic markers of late-outgrowth endothelial progenitor cells isolated from patients with coronary artery disease and healthy volunteers." Tissue Eng Part A 15, no. 11 (November 2009): 3473-3486.  Full Text  Link to Item
    • Mills, JS, N'diaye, CS, Yow, E, Urtz, M, Povsic, TJ, Greenfield, JC, and Phillips, HR. "Preliminary observations using optical coherence tomography to assess neointimal coverage of a metal stent in a porcine model." Cardiovasc Revasc Med 10, no. 4 (October 2009): 229-235.  Full Text  Link to Item
    • Povsic, TJ, Adams, SD, Zavodni, KL, Kelly, F, Melton, LG, Rao, SV, Najjar, SS, Harrington, RA, and Peterson, ED. "Aldehyde dehydrogenase activity allows reliable EPC enumeration in stored peripheral blood samples." J Thromb Thrombolysis 28, no. 3 (October 2009): 259-265.  Full Text  Link to Item
    • Povsic, TJ, Zavodni, KL, Vainorius, E, Kherani, JF, Goldschmidt-Clermont, PJ, and Peterson, ED. "Common endothelial progenitor cell assays identify discrete endothelial progenitor cell populations." Am Heart J 157, no. 2 (February 2009): 335-344.  Full Text  Link to Item
    • Zhu, S, Evans, S, Yan, B, Povsic, TJ, Tapson, V, Goldschmidt-Clermont, PJ, and Dong, C. "Transcriptional regulation of Bim by FOXO3a and Akt mediates scleroderma serum-induced apoptosis in endothelial progenitor cells." Circulation 118, no. 21 (November 3, 2008): 2156-2165.  Full Text
    • Povsic, TJ, and Goldschmidt-Clermont, PJ. "Endothelial progenitor cells: markers of vascular reparative capacity." Ther Adv Cardiovasc Dis 2, no. 3 (June 2008): 199-213. (Review)  Full Text  Link to Item
    • Povsic, TJ, Zavodni, KL, Kelly, FL, Zhu, S, Goldschmidt-Clermont, PJ, Dong, C, and Peterson, ED. "Circulating progenitor cells can be reliably identified on the basis of aldehyde dehydrogenase activity." J Am Coll Cardiol 50, no. 23 (December 4, 2007): 2243-2248.  Full Text  Link to Item
    • Povsic, TJ, and Peterson, ED. "Stem cells for the ischaemic heart." Expert Opin Biol Ther 6, no. 5 (May 2006): 427-442. (Review)  Full Text  Link to Item
    • Povsic, TJ, and Peterson, ED. "Progenitor cell therapy of ischemic heart disease: the new frontier." Future Cardiol 1, no. 1 (January 2005): 87-98.  Full Text  Link to Item
    • Povsic, TJ, Kohout, TA, and Lefkowitz, RJ. "Beta-arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of phosphatidylinositol 3-kinase (PI3K) and anti-apoptosis." The Journal of Biological Chemistry 278, no. 51 (December 2003): 51334-51339.  Full Text
    • Gallo, RL, Ono, M, Povsic, T, Page, C, Eriksson, E, Klagsbrun, M, and Bernfield, M. "Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds." Proceedings of the National Academy of Sciences of the United States of America 91, no. 23 (November 1994): 11035-11039.  Full Text
    • Povsic, TJ, Strobel, SA, and Dervan, PB. "Sequence-specific double-strand alkylation and cleavage of dna mediated by triple-helix formation." Journal of the American Chemical Society 114, no. 15 (1992): 5934-5941.
    • Povsic, TJ, and Dervan, PB. "Sequence-specific alkylation of double-helical DNA by oligonucleotide-directed triple-helix formation." Journal of the American Chemical Society 112, no. 25 (1990): 9428-9430.
    • Povsic, TJ, and Dervan, PB. "Triple helix formation by oligonucleotides on DNA extended to the physiological pH range." Journal of the American Chemical Society 111, no. 8 (1989): 3059-3061.

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