Scholars@Duke

• Background
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  Education, Training, & Certifications

  • Ph.D., Massachusetts Institute of Technology 2020
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  Previous Appointments & Affiliations

  • Visiting Assistant Professor in the Department of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2022
• Research
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  External Relationships

  • Buck Institute for Research on Aging
  • Gameto, Inc.
  • UbiquiTx, Inc.
  • Yokogawa
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Kobayashi, Mutsumi, Misato Kobayashi, Junko Odajima, Keiko Shioda, Young Sun Hwang, Kotaro Sasaki, Pranam Chatterjee, et al. “Expanding homogeneous culture of human primordial germ cell-like cells maintaining germline features without serum or feeder layers.” Stem Cell Reports 17, no. 3 (March 2022): 507–21. https://doi.org/10.1016/j.stemcr.2022.01.012.
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    • Kramme, Christian, Alexandru M. Plesa, Helen H. Wang, Bennett Wolf, Merrick Pierson Smela, Xiaoge Guo, Richie E. Kohman, Pranam Chatterjee, and George M. Church. “MegaGate: A toxin-less gateway molecular cloning tool.” Star Protocols 2, no. 4 (December 2021): 100907. https://doi.org/10.1016/j.xpro.2021.100907.
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    • Kramme, Christian, Alexandru M. Plesa, Helen H. Wang, Bennett Wolf, Merrick Pierson Smela, Xiaoge Guo, Richie E. Kohman, Pranam Chatterjee, and George M. Church. “An integrated pipeline for mammalian genetic screening.” Cell Reports Methods 1, no. 6 (October 2021): 100082. https://doi.org/10.1016/j.crmeth.2021.100082.
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    • Qing, Rui, Fei Tao, Pranam Chatterjee, Gaojie Yang, Qiuyi Han, Haeyoon Chung, Jun Ni, et al. “Non-full-length Water-Soluble CXCR4QTY and CCR5QTY Chemokine Receptors: Implication for Overlooked Truncated but Functional Membrane Receptors.” Iscience 23, no. 12 (December 2020): 101670–101670. https://doi.org/10.1016/j.isci.2020.101670.
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    • Chatterjee, Pranam, Manvitha Ponnapati, Christian Kramme, Alexandru M. Plesa, George M. Church, and Joseph M. Jacobson. “Targeted intracellular degradation of SARS-CoV-2 via computationally optimized peptide fusions.” Communications Biology 3, no. 1 (November 2020): 715. https://doi.org/10.1038/s42003-020-01470-7.
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    • Chatterjee, Pranam, Noah Jakimo, Jooyoung Lee, Nadia Amrani, Tomás Rodríguez, Sabrina R. T. Koseki, Emma Tysinger, et al. “An engineered ScCas9 with broad PAM range and high specificity and activity.” Nature Biotechnology 38, no. 10 (October 2020): 1154–58. https://doi.org/10.1038/s41587-020-0517-0.
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    • Chatterjee, Pranam, Noah Jakimo, Jooyoung Lee, Nadia Amrani, Tomás Rodríguez, Sabrina R. T. Koseki, Emma Tysinger, et al. “Publisher Correction: An engineered ScCas9 with broad PAM range and high specificity and activity.” Nature Biotechnology 38, no. 10 (October 2020): 1212. https://doi.org/10.1038/s41587-020-0604-2.
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    • Chatterjee, Pranam, Jooyoung Lee, Lisa Nip, Sabrina R. T. Koseki, Emma Tysinger, Erik J. Sontheimer, Joseph M. Jacobson, and Noah Jakimo. “A Cas9 with PAM recognition for adenine dinucleotides.” Nature Communications 11, no. 1 (May 18, 2020). https://doi.org/10.1038/s41467-020-16117-8.
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    • Chatterjee, Pranam, Noah Jakimo, and Joseph M. Jacobson. “Minimal PAM specificity of a highly similar SpCas9 ortholog.” Science Advances 4, no. 10 (October 2018): eaau0766. https://doi.org/10.1126/sciadv.aau0766.
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    • Patsoukis, Nikolaos, Kankana Bardhan, Pranam Chatterjee, Duygu Sari, Bianling Liu, Lauren N. Bell, Edward D. Karoly, et al. “PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation.” Nature Communications 6 (March 2015): 6692. https://doi.org/10.1038/ncomms7692.
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    • Boussiotis, Vassiliki A., Pranam Chatterjee, and Lequn Li. “Biochemical Signaling of PD-1 on T Cells and Its Functional Implications.” The Cancer Journal 20, no. 4 (July 2014): 265–71. https://doi.org/10.1097/ppo.0000000000000059.
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  • Preprints

    • Palepu, Kalyan, Manvitha Ponnapati, Suhaas Bhat, Emma Tysinger, Teodora Stan, Garyk Brixi, Sabrina R. T. Koseki, and Pranam Chatterjee. “Design of Peptide-Based Protein Degraders via Contrastive Deep Learning.” BioRxiv, 2022. https://doi.org/10.1101/2022.05.23.493169.
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    • Costa, Allan, Manvitha Ponnapati, Joseph Jacobson, and Pranam Chatterjee. “Distillation of MSA Embeddings to Folded Protein Structures with Graph Transformers.” BioRxiv, 2021. https://doi.org/10.1101/2021.06.02.446809.
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    • Tripathy, Soumya, Manvitha Ponnapati, Joseph Jacobson, and Pranam Chatterjee. “Sub-Picomolar Detection of SARS-CoV-2 RBD via Computationally-Optimized Peptide Beacons.” BioRxiv, 2021. https://doi.org/10.1101/2021.06.04.447114.
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    • Chatterjee, Pranam, Manvitha Ponnapati, Christian Kramme, Alex Plesa, Joseph Jacobson, and George Church. “Targeted Intracellular Degradation of SARS-CoV-2 via Computationally-Optimized Peptide Fusions.” Research Square, 2020. https://doi.org/10.21203/rs.3.rs-63127/v1.
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    • Chatterjee, Pranam, Manvitha Ponnapati, and Joseph Jacobson. “Targeted Intracellular Degradation of SARS-CoV-2 RBD via Computationally-Optimized Peptide Fusions.” BioRxiv, 2020. https://doi.org/10.1101/2020.06.01.127829.
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    • Chatterjee, Pranam, Noah Jakimo, and Joseph Jacobson. “Robust Genome Editing of Single-Base PAM Targets with Engineered ScCas9 Variants.” BioRxiv, 2019. https://doi.org/10.1101/620351.
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    • Jakimo, Noah, Pranam Chatterjee, Lisa Nip, and Joseph Jacobson. “A Cas9 with Complete PAM Recognition for Adenine Dinucleotides.” BioRxiv, 2018. https://doi.org/10.1101/429654.
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• Teaching & Mentoring
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  Recent Courses

  • BME 494: Projects in Biomedical Engineering (GE) 2023
  • BME 590: Special Topics in Biomedical Engineering 2023
  • BME 791: Graduate Independent Study 2023
  • EGR 393: Research Projects in Engineering 2023
  • BME 390L: Special Topics with a Lab 2022
  • BME 493: Projects in Biomedical Engineering (GE) 2022
  • BME 791: Graduate Independent Study 2022
  • EGR 393: Research Projects in Engineering 2022

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