Current Appointments & Affiliations
Assistant Professor of Biomedical Engineering
·
2022 - Present
Biomedical Engineering,
Pratt School of Engineering
Assistant Professor of Computer Science
·
2023 - Present
Computer Science,
Trinity College of Arts & Sciences
Assistant Professor in Biostatistics & Bioinformatics
·
2023 - Present
Biostatistics & Bioinformatics,
Basic Science Departments
Member of the Duke Cancer Institute
·
2024 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
FusOn-pLM: a fusion oncoprotein-specific language model via adjusted rate masking.
Journal Article Nature communications · February 2025 Fusion oncoproteins, a class of chimeric proteins arising from chromosomal translocations, are major drivers of various pediatric cancers. These proteins are intrinsically disordered and lack druggable pockets, making them highly challenging therapeutic ta ... Full text CiteGenerative latent diffusion language modeling yields anti-infective synthetic peptides.
Preprint · February 1, 2025 Full text Link to item CiteDe novo design of peptide binders to conformationally diverse targets with contrastive language modeling.
Journal Article Sci Adv · January 24, 2025 Designing binders to target undruggable proteins presents a formidable challenge in drug discovery. In this work, we provide an algorithmic framework to design short, target-binding linear peptides, requiring only the amino acid sequence of the target prot ... Full text Link to item CiteRecent Grants
Generative Design of Programmable Therapeutics
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2029Medical Scientist Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027University Training Program in Biomolecular and Tissue Engineering
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1994 - 2027View All Grants
Education, Training & Certifications
Massachusetts Institute of Technology ·
2020
Ph.D.