Current Appointments & Affiliations
Assistant Professor of Biomedical Engineering
·
2022 - Present
Biomedical Engineering,
Pratt School of Engineering
Assistant Professor of Computer Science
·
2023 - Present
Computer Science,
Trinity College of Arts & Sciences
Assistant Professor in Biostatistics & Bioinformatics
·
2023 - Present
Biostatistics & Bioinformatics, Division of Integrative Genomics,
Biostatistics & Bioinformatics
Member of the Duke Cancer Institute
·
2024 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
DPAC: Prediction and Design of Protein-DNA Interactions via Sequence-Based Contrastive Learning
Preprint · May 19, 2025 Full text CitePTM-Mamba: a PTM-aware protein language model with bidirectional gated Mamba blocks.
Journal Article Nature methods · May 2025 Current protein language models (LMs) accurately encode protein properties but have yet to represent post-translational modifications (PTMs), which are crucial for proteomic diversity and influence protein structure, function and interactions. To address t ... Full text CiteProgrammable protein stabilization with language model-derived peptide guides.
Journal Article Nature communications · April 2025 Dysregulated protein degradation via the ubiquitin-proteasomal pathway can induce numerous disease phenotypes, including cancer, neurodegeneration, and diabetes. While small molecule-based targeted protein degradation (TPD) and targeted protein stabilizati ... Full text CiteRecent Grants
Generative Design of Programmable Therapeutics
ResearchPrincipal Investigator · Awarded by National Institute of General Medical Sciences · 2024 - 2029Medical Scientist Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027University Training Program in Biomolecular and Tissue Engineering
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1994 - 2027View All Grants
Education, Training & Certifications
Massachusetts Institute of Technology ·
2020
Ph.D.