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Priyamvada Acharya

Priyamvada Acharya

Professor in Surgery
Surgery, Surgical Sciences
priyamvada.acharya@duke.edu
DUMC Box 103020, Durham, NC 27710
10 Circuit Drive, Room 101, Research Park II, Durham, NC 27710

Current Appointments & Affiliations

Professor in Surgery · 2024 - Present Surgery, Surgical Sciences, Surgery
Professor of Biochemistry · 2026 - Present Biochemistry, Basic Science Departments
Member of the Duke Human Vaccine Institute · 2018 - Present Duke Human Vaccine Institute, Institutes and Centers
Member of the Duke Cancer Institute · 2025 - Present Duke Cancer Institute, Institutes and Centers

In the News

Published September 12, 2024
Omicron Insights May Shape Future of Vaccine Design
Published June 28, 2022
Duke Awarded Federal Grant to Build Structural Models of HIV
Published June 29, 2021
Duke Researchers Point to Protein Spike as the Key to SARS Viral Variations & Increased Transmission

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Recent Publications

Distinct allosteric remodeling of HIV-1 Env dynamics on virions by gp41-directed antibodies reveals two modes of neutralization.

Journal Article bioRxiv · January 28, 2026 HIV-1 envelope glycoprotein (Env), a gp120-gp41 trimer, undergoes coordinated conformational changes that drive membrane fusion and allow immune evasion by transiently concealing neutralization-sensitive epitopes. Most broadly neutralizing antibodies (bNAb ... Full text Link to item Cite

An integrated workflow for structural virology with a 100 keV electron microscope.

Journal Article bioRxiv · December 10, 2025 Cryo-EM has revolutionized structural biology, especially for flexible and heterogeneous samples, although access to high end microscopes that enable these studies remains a bottleneck. While 300 keV microscopes have been the go-to for high-resolution stru ... Full text Link to item Cite
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Recent Grants

Discovery and Optimization of Broadly Protective Merbecovirus Neutralizing Antibodies

ResearchCollaborator · Awarded by National Institutes of Health · 2026 - 2031

Interdisciplinary Research Training Program in AIDS

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2010 - 2030

Structural definition of CD4-induced HIV-1 Env conformational changes required for infection

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2030

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Education

Centre for Cellular and Molecular Biology (India) · 2003 Ph.D.
Jadavpur University (India) · 1996 M.S.
Jadavpur University (India) · 1994 B.S.