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Priyamvada Acharya

Professor in Surgery
Surgery, Surgical Sciences
DUMC Box 103020, Durham, NC 27710
10 Circuit Drive, Room 101, Research Park II, Durham, NC 27710

Current Appointments & Affiliations


Professor in Surgery · 2024 - Present Surgery, Surgical Sciences, Surgery
Associate Professor of Biochemistry · 2021 - Present Biochemistry, Basic Science Departments
Member of the Duke Human Vaccine Institute · 2018 - Present Duke Human Vaccine Institute, Institutes and Centers

In the News


Published September 12, 2024
Omicron Insights May Shape Future of Vaccine Design
Published June 28, 2022
Duke Awarded Federal Grant to Build Structural Models of HIV
Published June 29, 2021
Duke Researchers Point to Protein Spike as the Key to SARS Viral Variations & Increased Transmission

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Recent Publications


Breast milk delivery of an engineered dimeric IgA protects neonates against rotavirus.

Journal Article Mucosal Immunol · April 2025 Dimeric IgA (dIgA) is the dominant antibody in many mucosal tissues. It is actively transported onto mucosal surfaces as secretory IgA (sIgA) which plays an integral role in protection against enteric pathogens, particularly in young children. Therapeutic ... Full text Link to item Cite

An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations.

Journal Article Sci Transl Med · January 8, 2025 Elicitation of HIV broadly neutralizing antibodies (bnAbs) by vaccination first requires the activation of diverse precursors, followed by successive boosts that guide these responses to enhanced breadth through the acquisition of somatic mutations. Becaus ... Full text Link to item Cite

Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies.

Journal Article Nat Commun · November 3, 2024 Vaccine development targeting rapidly evolving pathogens such as HIV-1 requires induction of broadly neutralizing antibodies (bnAbs) with conserved paratopes and mutations, and in some cases, the same Ig-heavy chains. The current trial-and-error search for ... Full text Link to item Cite
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Recent Grants


Duke Center for HIV Structural Biology

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2027

Structural and biophysical studies on natural SARS-CoV-2 variants

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2027

Structural characterization of Fab-dimerized glycan-reactive antibodies that neutralize HIV-1

ResearchPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2021 - 2026

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Education, Training & Certifications


Centre for Cellular and Molecular Biology (India) · 2003 Ph.D.
Jadavpur University (India) · 1996 M.S.
Jadavpur University (India) · 1994 B.S.