Current Appointments & Affiliations
Professor in Surgery
·
2024 - Present
Surgery, Surgical Sciences,
Surgery
Associate Professor of Biochemistry
·
2021 - Present
Biochemistry,
Basic Science Departments
Member of the Duke Human Vaccine Institute
·
2018 - Present
Duke Human Vaccine Institute,
Institutes and Centers
Recent Publications
Breast milk delivery of an engineered dimeric IgA protects neonates against rotavirus.
Journal Article Mucosal Immunol · April 2025 Dimeric IgA (dIgA) is the dominant antibody in many mucosal tissues. It is actively transported onto mucosal surfaces as secretory IgA (sIgA) which plays an integral role in protection against enteric pathogens, particularly in young children. Therapeutic ... Full text Link to item CiteAn engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations.
Journal Article Sci Transl Med · January 8, 2025 Elicitation of HIV broadly neutralizing antibodies (bnAbs) by vaccination first requires the activation of diverse precursors, followed by successive boosts that guide these responses to enhanced breadth through the acquisition of somatic mutations. Becaus ... Full text Link to item CiteEngineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies.
Journal Article Nat Commun · November 3, 2024 Vaccine development targeting rapidly evolving pathogens such as HIV-1 requires induction of broadly neutralizing antibodies (bnAbs) with conserved paratopes and mutations, and in some cases, the same Ig-heavy chains. The current trial-and-error search for ... Full text Link to item CiteRecent Grants
Duke Center for HIV Structural Biology
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2027Structural and biophysical studies on natural SARS-CoV-2 variants
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2027Structural characterization of Fab-dimerized glycan-reactive antibodies that neutralize HIV-1
ResearchPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2021 - 2026View All Grants
Education, Training & Certifications
Centre for Cellular and Molecular Biology (India) ·
2003
Ph.D.
Jadavpur University (India) ·
1996
M.S.
Jadavpur University (India) ·
1994
B.S.