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Ram Sharma Puranam

Adjunct Assistant Professor in the Department of Neurology
Neurology, Epilepsy and Sleep
Duke Box 3676, Durham, NC 27710
401 Bryan Res Bldg, Durham, NC 27710

Current Appointments & Affiliations


Adjunct Assistant Professor in the Department of Neurology · 2023 - Present Neurology, Epilepsy and Sleep, Neurology

Recent Publications


Long-Term Potentiation of Mossy Fiber Feedforward Inhibition of CA3 Pyramidal Cells Maintains E/I Balance in Epilepsy Model.

Journal Article eNeuro · 2022 Insight into the cellular and circuit mechanisms underlying development of temporal lobe epilepsy (TLE) will provide a foundation for improved therapies. We studied a model in which an episode of prolonged seizures is followed by recovery lasting two weeks ... Full text Link to item Cite

Adeno-Associated Virus-Mediated Gene Therapy in the Mashlool, Atp1a3Mashl/+, Mouse Model of Alternating Hemiplegia of Childhood.

Journal Article Hum Gene Ther · April 2021 Alternating Hemiplegia of Childhood (AHC) is a devastating autosomal dominant disorder caused by ATP1A3 mutations, resulting in severe hemiplegia and dystonia spells, ataxia, debilitating disabilities, and premature death. Here, we determine the effects of ... Full text Link to item Cite

Is FGF13 a major contributor to genetic epilepsy with febrile seizures plus?

Journal Article Epilepsy Res · December 2016 Mutation of fibroblast growth factor 13 (FGF13) has recently been implicated in genetic epilepsy with febrile seizures plus (GEFS+) in a single family segregating a balanced translocation with a breakpoint in this X chromosome gene, predicting a partial kn ... Full text Link to item Cite
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Recent Grants


Cellular and Circuit Mechanisms of Temporal Lobe Epilepsy

ResearchAssistant Research Professor · Awarded by National Institutes of Health · 2017 - 2023

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Education, Training & Certifications


Indian Institute of Science (India) · 1986 Ph.D.