Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Indian Institute of Science (India) 1986
• 

  Previous Appointments & Affiliations

  • Assistant Professor in Neurology, Neurology, Epilepsy and Sleep, Neurology 2021 - 2022
  • Assistant Professor of Neurology, Neurology, Epilepsy and Sleep, Neurology 2013 - 2020
  • Assistant Professor in Medicine, Neurology, Clinical Science Departments 2006 - 2013
  • Assistant Research Professor in Medicine, Neurology, Clinical Science Departments 1994 - 2006
• Research
• 

  Selected Grants

  • Cellular and Circuit Mechanisms of Temporal Lobe Epilepsy awarded by National Institutes of Health 2017 - 2023
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Pan, Enhui, Ram S. Puranam, and James O. McNamara. “Long-Term Potentiation of Mossy Fiber Feedforward Inhibition of CA3 Pyramidal Cells Maintains E/I Balance in Epilepsy Model.” Eneuro 9, no. 1 (2022). https://doi.org/10.1523/ENEURO.0375-21.2021.
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    • Hunanyan, Arsen S., Boris Kantor, Ram S. Puranam, Courtney Elliott, Angela McCall, Justin Dhindsa, Promila Pagadala, et al. “Adeno-Associated Virus-Mediated Gene Therapy in the Mashlool, Atp1a3Mashl/+, Mouse Model of Alternating Hemiplegia of Childhood.” Hum Gene Ther 32, no. 7–8 (April 2021): 405–19. https://doi.org/10.1089/hum.2020.191.
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    • Rigbye, Kristin A., Peter M. van Hasselt, Rosemary Burgess, John A. Damiano, Saul A. Mullen, Slavé Petrovski, Ram S. Puranam, et al. “Is FGF13 a major contributor to genetic epilepsy with febrile seizures plus?” Epilepsy Res 128 (December 2016): 48–51. https://doi.org/10.1016/j.eplepsyres.2016.10.008.
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    • Puranam, Ram S., Xiao Ping He, Lijun Yao, Tri Le, Wonjo Jang, Catherine W. Rehder, Darrell V. Lewis, and James O. McNamara. “Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus.” J Neurosci 35, no. 23 (June 10, 2015): 8866–81. https://doi.org/10.1523/JNEUROSCI.3470-14.2015.
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    • Soren Leonard, A., Ram S. Puranam, Jeffrey Helgager, Gumei Liu, and James O. McNamara. “Conditional deletion of TrkC does not modify limbic epileptogenesis.” Epilepsy Res 102, no. 1–2 (November 2012): 126–30. https://doi.org/10.1016/j.eplepsyres.2012.07.019.
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    • Heinzen, Erin L., Chantal Depondt, Gianpiero L. Cavalleri, Elizabeth K. Ruzzo, Nicole M. Walley, Anna C. Need, Dongliang Ge, et al. “Exome sequencing followed by large-scale genotyping fails to identify single rare variants of large effect in idiopathic generalized epilepsy.” Am J Hum Genet 91, no. 2 (August 10, 2012): 293–302. https://doi.org/10.1016/j.ajhg.2012.06.016.
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    • Wang, Chuan, Jessica A. Hennessey, Robert D. Kirkton, Chaojian Wang, Victoria Graham, Ram S. Puranam, Paul B. Rosenberg, Nenad Bursac, and Geoffrey S. Pitt. “Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts.” Circ Res 109, no. 7 (September 16, 2011): 775–82. https://doi.org/10.1161/CIRCRESAHA.111.247957.
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    • Puranam, Ram S., Satish Jain, Amber M. Kleindienst, Shilpa Saxena, Myeong-Kyu Kim, Barbara Kelly Changizi, M. V. Padma, et al. “A locus for generalized tonic-clonic seizure susceptibility maps to chromosome 10q25-q26.” Ann Neurol 58, no. 3 (September 2005): 449–58. https://doi.org/10.1002/ana.20598.
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    • Panda, S., M. Tripathi, S. Jain, and P. Sharma. “X-linked lissencephaly in an Indian family.” Neurol India 51, no. 3 (September 2003): 392–93.
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    • Barnes, Gregory, Ram S. Puranam, Yuling Luo, and James O. McNamara. “Temporal specific patterns of semaphorin gene expression in rat brain after kainic acid-induced status epilepticus.” Hippocampus 13, no. 1 (2003): 1–20. https://doi.org/10.1002/hipo.10041.
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    • Rossmanith, W., and T. Potuschak. “Difference between mitochondrial RNase P and nuclear RNase P.” Mol Cell Biol 21, no. 23 (December 2001): 8236–37. https://doi.org/10.1128/MCB.21.23.8236-8237.2001.
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    • Puranam, R. S., and J. O. McNamara. “Epilepsy and all that jazz.” Nat Med 7, no. 10 (October 2001): 1103–5. https://doi.org/10.1038/nm1001-1103.
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    • Puranam, R. S., and G. Attardi. “The RNase P associated with HeLa cell mitochondria contains an essential RNA component identical in sequence to that of the nuclear RNase P.” Mol Cell Biol 21, no. 2 (January 2001): 548–61. https://doi.org/10.1128/MCB.21.2.548-561.2001.
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    • Yang, R., R. S. Puranam, L. S. Butler, W. H. Qian, X. P. He, M. B. Moyer, K. Blackburn, P. I. Andrews, and J. O. McNamara. “Erratum: Autoimmunity to Munc-18 in Rasmussen's Encephalitis (Neuron (November 2000) 28 (375-383)).” Neuron 29, no. 2 (January 1, 2001): 547. https://doi.org/10.1016/S0896-6273(01)00226-4.
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    • Yang, R., R. S. Puranam, L. S. Butler, W. H. Qian, X. P. He, M. B. Moyer, K. Blackburn, P. I. Andrews, and J. O. McNamara. “Autoimmunity to munc-18 in Rasmussen's encephalitis.” Neuron 28, no. 2 (November 2000): 375–83. https://doi.org/10.1016/s0896-6273(00)00118-5.
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    • Puranam, R. S., and J. O. McNamara. “Seizure disorders in mutant mice: relevance to human epilepsies.” Curr Opin Neurobiol 9, no. 3 (June 1999): 281–87. https://doi.org/10.1016/s0959-4388(99)80041-5.
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    • Wilson, M. H., R. S. Puranam, R. Ottman, C. Gilliam, L. E. Limbird, A. L. George, and J. O. McNamara. “Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy.” Neurology 51, no. 6 (December 1998): 1730–31. https://doi.org/10.1212/wnl.51.6.1730.
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    • Guan, M. X., J. A. Enriquez, N. Fischel-Ghodsian, R. S. Puranam, C. P. Lin, M. A. Maw, and G. Attardi. “The deafness-associated mitochondrial DNA mutation at position 7445, which affects tRNASer(UCN) precursor processing, has long-range effects on NADH dehydrogenase subunit ND6 gene expression.” Mol Cell Biol 18, no. 10 (October 1998): 5868–79. https://doi.org/10.1128/MCB.18.10.5868.
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    • Puranam, R. S., and J. O. McNamara. “Stargazing nets new calcium channel subunit.” Nat Genet 19, no. 4 (August 1998): 313–14. https://doi.org/10.1038/1194.
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    • McNamara, J. O., and R. S. Puranam. “Epilepsy genetics: an abundance of riches for biologists.” Curr Biol 8, no. 5 (February 26, 1998): R168–70. https://doi.org/10.1016/s0960-9822(98)70102-2.
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    • McNamara, J. O., and R. S. Puranam. “Epilepsy. Protease inhibitor implicated.” Nature 381, no. 6577 (May 2, 1996): 26–27. https://doi.org/10.1038/381026a0.
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    • Shafqat, S., B. K. Tamarappoo, M. S. Kilberg, R. S. Puranam, J. O. McNamara, A. Guadano-Ferraz, and R. T. Fremeau. “Erratum: Cloning and expression of a novel Na⁺-dependent neutral amino acid transporter structurally related to mammalian Na⁺/glutamate cotransporters (Journal of Biological Chemistry (1993) 268 (15351-15355)).” Journal of Biological Chemistry 269, no. 31 (January 1, 1994): 20208.
    • Altman, S., D. Wesolowski, and R. S. Puranam. “Nucleotide sequences of the RNA subunit of RNase P from several mammals.” Genomics 18, no. 2 (November 1993): 418–22. https://doi.org/10.1006/geno.1993.1488.
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    • Puranam, R. S., J. H. Eubanks, S. F. Heinemann, and J. O. McNamara. “Chromosomal localization of gene for human glutamate receptor subunit-7.” Somat Cell Mol Genet 19, no. 6 (November 1993): 581–88. https://doi.org/10.1007/BF01233385.
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    • Shafqat, S., B. K. Tamarappoo, M. S. Kilberg, R. S. Puranam, J. O. McNamara, A. Guadaño-Ferraz, and R. T. Fremeau. “Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters.” J Biol Chem 268, no. 21 (July 25, 1993): 15351–55.
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    • Eubanks, J. H., R. S. Puranam, N. W. Kleckner, B. Bettler, S. F. Heinemann, and J. O. McNamara. “The gene encoding the glutamate receptor subunit GluR5 is located on human chromosome 21q21.1-22.1 in the vicinity of the gene for familial amyotrophic lateral sclerosis.” Proc Natl Acad Sci U S A 90, no. 1 (January 1, 1993): 178–82. https://doi.org/10.1073/pnas.90.1.178.
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    • Ramasarma, T., B. K. Rasheed, S. Vijaya, R. S. Puranam, V. Shivaswamy, A. S. Gaikwad, and C. K. Kurup. “Functions of cytochrome c in regulation of electron transfer and protein folding.” Indian J Biochem Biophys 29, no. 2 (April 1992): 173–78.
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    • Raj, R. K., R. S. Puranam, C. K. Kurup, and T. Ramasarma. “Oxidative activities in mitochondria-like particles from Setaria digitata, a filarial parasite.” Biochem J 256, no. 2 (December 1, 1988): 559–64. https://doi.org/10.1042/bj2560559.
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    • Puranam, R. S., S. D. Gupta, V. Shivaswamy, T. Ramasarma, and C. K. Kurup. “Regulation of electron transport in hepatic mitochondria on acclimation of animals to heat stress.” Indian J Biochem Biophys 24, no. 6 (December 1987): 314–20.
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    • Puranam, R. S., V. Shivaswamy, C. K. Kurup, and T. Ramasarma. “Oxidations in kidney mitochondria of heat-exposed rats: regulation by cytochrome c.” J Bioenerg Biomembr 16, no. 5–6 (December 1984): 421–31. https://doi.org/10.1007/BF00743236.
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    • Swaroop, A., M. S. Patole, R. S. Puranam, and T. Ramasarma. “Noradrenaline treatment of rats stimulates H2O2 generation in liver mitochondria.” Biochem J 214, no. 3 (September 15, 1983): 745–50. https://doi.org/10.1042/bj2140745.
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