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Qiuwen Wu

Professor of Radiation Oncology
Radiation Oncology
Box 3295 Med Ctr, Durham, NC 27710
00568 Duke South White Zone, Durham, NC 27710

Overview


My research interests include intensity-modulated radiation therapy (IMRT), volumetric-modulated arc therapy (VMAT), Dynamic Electron Arc Radiotherapy (DEAR), and image-guided radiation therapy (IGRT). For IMRT, my work includes the development of the research platform, fast and accurate dose calculations, optimization based on physical and biological objectives such as generalized equivalent uniform dose (gEUD), and delivery with a dynamic multi-leaf collimator (DMLC). For VMAT, I am interested in optimization, quality assurance, and novel applications. For DEAR, I'm interested in the treatment planning and delivery verifications. For IGRT, my work includes the development of the infrastructure of the online and offline image guidance, characterization of patient anatomic changes and treatment uncertainties, margin calculations, and adaptive treatment planning. My recent research interests also include the use of AI in treatment planning, Brachytherapy dose calculation and plan optimization.

My clinical interests include prostate cancer, head and neck cancer, total body irradiation (TBI), and total skin irradiation (TSI)

Current Duke Appointments & Affiliations


Professor of Radiation Oncology · 2021 - Present Radiation Oncology, Clinical Science Departments

Recent Scholarly Works


Reference-Free large language model agents for physician-guided radiotherapy treatment planning.

Journal article Med Phys · August 2026 BACKGROUND: Large language models (LLMs) have recently demonstrated exceptional capabilities, offering the potential to streamline workflows and enhance efficiency across diverse tasks. However, their application in domain-specific areas, such as radiother ... Full text Link to item Cite

Integrated optimization of needle paths and dwell time for individualized template-guided interstitial brachytherapy.

Journal article Med Phys · April 2026 BACKGROUND: 3D-printed individualized template (3D-PIT) guided interstitial brachytherapy (ISBT) is an effective treatment modality for cervical cancer. However, the current practice of pre-operative planning requires manual needle paths design, which is h ... Full text Link to item Cite

Feasibility study of a machine learning inspired approach for VMAT optimization.

Journal article Med Phys · April 2026 BACKGROUND: Despite the widespread clinical adoption of volumetric modulated arc therapy (VMAT), advances in its fundamental optimization methodology have remained relatively limited, particularly with respect to open and researcher-accessible optimization ... Full text Link to item Cite
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Recent Grants


Knowledge-based Tutoring for Knowledge-based Radiation Therapy

ResearchCo Investigator · Awarded by Varian Medical Systems, Inc. · 2020 - 2022

Cross-disciplinary Training in Medical Physics

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2007 - 2013

Image-Guide Radiation Therapy of Prostate Cancer

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2006 - 2011

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Education


Columbia University · 1994 Ph.D.