Overview
My research interests include intensity-modulated radiation therapy (IMRT), volumetric-modulated arc therapy (VMAT), Dynamic Electron Arc Radiotherapy (DEAR), and image-guided radiation therapy (IGRT). For IMRT, my work includes the development of the research platform, fast and accurate dose calculations, optimization based on physical and biological objectives such as generalized equivalent uniform dose (gEUD), and delivery with a dynamic multi-leaf collimator (DMLC). For VMAT, I am interested in optimization, quality assurance, and novel applications. For DEAR, I'm interested in the treatment planning and delivery verifications. For IGRT, my work includes the development of the infrastructure of the online and offline image guidance, characterization of patient anatomic changes and treatment uncertainties, margin calculations, and adaptive treatment planning. My recent research interests also include the use of AI in treatment planning, Brachytherapy dose calculation and plan optimization.
My clinical interests include prostate cancer, head and neck cancer, total body irradiation (TBI), and total skin irradiation (TSI)
My clinical interests include prostate cancer, head and neck cancer, total body irradiation (TBI), and total skin irradiation (TSI)
Current Duke Appointments & Affiliations
Professor of Radiation Oncology
·
2021 - Present
Radiation Oncology,
Clinical Science Departments
Recent Scholarly Works
Reference-Free large language model agents for physician-guided radiotherapy treatment planning.
Journal article Med Phys · August 2026 BACKGROUND: Large language models (LLMs) have recently demonstrated exceptional capabilities, offering the potential to streamline workflows and enhance efficiency across diverse tasks. However, their application in domain-specific areas, such as radiother ... Full text Link to item CiteIntegrated optimization of needle paths and dwell time for individualized template-guided interstitial brachytherapy.
Journal article Med Phys · April 2026 BACKGROUND: 3D-printed individualized template (3D-PIT) guided interstitial brachytherapy (ISBT) is an effective treatment modality for cervical cancer. However, the current practice of pre-operative planning requires manual needle paths design, which is h ... Full text Link to item CiteFeasibility study of a machine learning inspired approach for VMAT optimization.
Journal article Med Phys · April 2026 BACKGROUND: Despite the widespread clinical adoption of volumetric modulated arc therapy (VMAT), advances in its fundamental optimization methodology have remained relatively limited, particularly with respect to open and researcher-accessible optimization ... Full text Link to item CiteRecent Grants
Knowledge-based Tutoring for Knowledge-based Radiation Therapy
ResearchCo Investigator · Awarded by Varian Medical Systems, Inc. · 2020 - 2022Cross-disciplinary Training in Medical Physics
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2007 - 2013Image-Guide Radiation Therapy of Prostate Cancer
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2006 - 2011View All Grants
Education
Columbia University ·
1994
Ph.D.