Qiuwen Wu | Scholars@Duke

Qiuwen Wu
Professor of Radiation Oncology

My research interests include intensity-modulated radiation therapy (IMRT), volumetric modulated arc therapy (VMAT), electron arc therapy (EAT) and image-guided radiation therapy (IGRT). For IMRT, my work include the development of the research platform, fast and accurate dose calculations, optimization based on physical and biological objectives such as generalized equivalent uniform dose (gEUD), and delivery with dynamic multi-leaf collimator (DMLC). For VMAT, I am interested in the optimization, quality assurance and novel applications. For EAT, I'm interested in the treatment planning and delivery verifications. For IGRT, my work include development of the infrastructure of the online and offline image guidance, characterization of patient anatomic changes and treatment uncertainties, margin calculations, and adaptive treatment planning.

My clinical interests include prostate cancer, head and neck cancer, breast cancer and lung cancer.

Current Appointments & Affiliations

Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2009

Contact Information

00568 Duke South White Zone, Durham, NC 27710
Box 3295 Med Ctr, Durham, NC 27710
qiuwen.wu@duke.edu (919) 613-6727

Background
Education, Training, & Certifications
- Ph.D., Columbia University 1994
Duke Appointment History
- Instructor, Temporary in the Department of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2009
Research
Selected Grants
- Knowledge-based Tutoring for Knowledge-based Radiation Therapy 2020 - 2021
- Cross-disciplinary Training in Medical Physics awarded by National Institutes of Health 2007 - 2013
- Image-Guide Radiation Therapy of Prostate Cancer awarded by National Institutes of Health 2006 - 2011
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Li, Ruiqi, Wenchih Tseng, and Qiuwen Wu. “Validation of the dosimetry of total skin irradiation techniques by Monte Carlo simulation.” J Appl Clin Med Phys, June 19, 2020. https://doi.org/10.1002/acm2.12921.
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  - Wei, Ran, Bo Liu, Fugen Zhou, Xiangzhi Bai, Dongshan Fu, Bin Liang, and Qiuwen Wu. “A patient-independent CT intensity matching method using conditional generative adversarial networks (cGAN) for single x-ray projection based tumor localization.” Phys Med Biol, April 22, 2020. https://doi.org/10.1088/1361-6560/ab8bf2.
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  - Zhang, Jiahan, Yaorong Ge, Yang Sheng, Chunhao Wang, Jiang Zhang, Yuan Wu, Qiuwen Wu, Fang-Fang Yin, and Q Jackie Wu. “Knowledge-Based Tradeoff Hyperplanes for Head and Neck Treatment Planning.” Int J Radiat Oncol Biol Phys 106, no. 5 (April 1, 2020): 1095–1103. https://doi.org/10.1016/j.ijrobp.2019.12.034.
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  - Wei, Ran, Fugen Zhou, Bo Liu, Xiangzhi Bai, Dongshan Fu, Bin Liang, and Qiuwen Wu. “Real-time tumor localization with single x-ray projection at arbitrary gantry angles using a convolutional neural network (CNN).” Phys Med Biol 65, no. 6 (March 19, 2020): 065012. https://doi.org/10.1088/1361-6560/ab66e4.
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  - Wang, Xiaorong, Daren Sawkey, and Qiuwen Wu. “Technical Note: A dose calculation framework for dynamic electron arc radiotherapy (DEAR) using VirtuaLinac Monte Carlo simulation tool.” Med Phys 47, no. 1 (January 2020): 164–70. https://doi.org/10.1002/mp.13882.
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  - Song, Haijun, Joseph K. Salama, William Robert Lee, and Qiuwen Wu. “Nonuniform Planning Target Volume Margins for Prostate Bed on the Basis of Surgical Clips on Daily Cone Beam Computed Tomography.” Adv Radiat Oncol 4, no. 1 (January 2019): 186–90. https://doi.org/10.1016/j.adro.2018.09.014.
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  - Wei, R., F. Zhou, B. Liu, X. Bai, D. Fu, Y. Li, B. Liang, and Q. Wu. “Convolutional Neural Network (CNN) Based Three Dimensional Tumor Localization Using Single X-Ray Projection.” Ieee Access 7 (January 1, 2019): 37026–38. https://doi.org/10.1109/ACCESS.2019.2899385.
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  - Van den Heuvel, Frank, Qiuwen Wu, and Jing Cai. “In modern linacs monitor units should be defined in water at 10 cm depth rather than at dmax.” Med Phys 45, no. 11 (November 2018): 4789–92. https://doi.org/10.1002/mp.13015.
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  - Liang, Bin, Yongbao Li, Ran Wei, Bin Guo, Xuang Xu, Bo Liu, Jiafeng Li, Qiuwen Wu, and Fugen Zhou. “A singular value decomposition linear programming (SVDLP) optimization technique for circular cone based robotic radiotherapy.” Phys Med Biol 63, no. 1 (January 5, 2018): 015034. https://doi.org/10.1088/1361-6560/aa9b47.
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  - Zhou, Sumin, Qiuwen Wu, Xiaobo Li, Rongtao Ma, Dandan Zheng, Shuo Wang, Mutian Zhang, et al. “Using weighted power mean for equivalent square estimation.” J Appl Clin Med Phys 18, no. 6 (November 2017): 194–99. https://doi.org/10.1002/acm2.12201.
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  - Zhao, Yu-Ting, Zhi-Kai Liu, Qiu-Wen Wu, Jian-Rong Dai, Tao Zhang, Angela Y. Jia, Jing Jin, Shu-Lian Wang, Ye-Xiong Li, and Wei-Hu Wang. “Observation of different tumor motion magnitude within liver and estimate of internal motion margins in postoperative patients with hepatocellular carcinoma.” Cancer Manag Res 9 (2017): 839–48. https://doi.org/10.2147/CMAR.S147185.
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  - Liang, Bin, Bo Liu, Fugen Zhou, Fang-Fang Yin, and Qiuwen Wu. “Comparisons of volumetric modulated arc therapy (VMAT) quality assurance (QA) systems: sensitivity analysis to machine errors.” Radiat Oncol 11, no. 1 (November 7, 2016): 146. https://doi.org/10.1186/s13014-016-0725-4.
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  - Liang, Bin, Yongbao Li, Bo Liu, Fugen Zhou, Shouping Xu, and Qiuwen Wu. “A pencil beam dose calculation model for CyberKnife system.” Med Phys 43, no. 10 (October 2016): 5380. https://doi.org/10.1118/1.4962029.
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  - Faught, A., Q. Wu, and J. Adamson. “SU-F-T-283: A Novel Device to Enable Portal Dosimetry for Flattening Filter Free Beams.” Med Phys 43, no. 6 (June 2016): 3527–28. https://doi.org/10.1118/1.4956423.
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  - Liang, B., B. Liu, Y. Li, B. Guo, X. Xu, R. Wei, F. Zhou, and Q. Wu. “SU-F-T-347: An Absolute Dose-Volume Constraint Based Deterministic Optimization Framework for Multi-Co60 Source Focused Radiotherapy.” Med Phys 43, no. 6 (June 2016): 3543. https://doi.org/10.1118/1.4956532.
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  - Liang, B., Y. Li, B. Liu, B. Guo, X. Xu, R. Wei, F. Zhou, S. Xu, and Q. Wu. “SU-G-TeP1-08: LINAC Head Geometry Modeling for Cyber Knife System.” Med Phys 43, no. 6 (June 2016): 3653. https://doi.org/10.1118/1.4956998.
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  - Liu, B., B. Liang, X. Xu, B. Guo, R. Wei, S. Xu, F. Zhou, and Q. Wu. “TU-H-CAMPUS-IeP2-02: Four-Dimensional Coronary Artery Visualization Based On Image Propagation.” Med Phys 43, no. 6 (June 2016): 3780–81. https://doi.org/10.1118/1.4957680.
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  - Wu, Q. “TH-AB-BRB-02: ET-Reloaded.” Med Phys 43, no. 6 (June 2016): 3853. https://doi.org/10.1118/1.4958048.
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  - Wu, Q., J. Adamson, B. Liang, B. Liu, and F. Zhou. “SU-G-TeP4-01: A High Resolution Pre-Treatment VMAT QA Technique Based On EPID for Single Isocenter Multiple Mets Stereotactic Radiosurgery.” Med Phys 43, no. 6 (June 2016): 3685. https://doi.org/10.1118/1.4957126.
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  - Zhou, S., Q. Wu, Q. Fan, Y. Lei, S. Li, X. Li, R. Ma, et al. “SU-G-BRC-17: Using Generalized Mean for Equivalent Square Estimation.” Med Phys 43, no. 6 (June 2016): 3630–31. https://doi.org/10.1118/1.4956907.
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  - Zhou, S., Q. Wu, Q. Fan, Y. Lei, S. Li, X. Li, R. Ma, et al. “SU-G-TeP2-14: Universal Function Form for Photon Open Field In-Water Output Ratio.” Med Phys 43, no. 6 (June 2016): 3666. https://doi.org/10.1118/1.4957049.
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  - Faught, A., and Q. Wu. “SU-E-T-317: Dosimetric Evaluation of Acuros XB Advanced Dose Calculation Algorithm in Head and Neck Patients.” Med Phys 42, no. 6 (June 2015): 3406. https://doi.org/10.1118/1.4924678.
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  - Liang, B., B. Liu, F. Yin, F. Zhou, and Q. Wu. “SU-E-T-690: Sensitivity Analysis to Machine Error: Comparisons of VMAT QA Systems.” Med Phys 42, no. 6 (June 2015): 3495. https://doi.org/10.1118/1.4925053.
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  - Liang, B., B. Liu, F. Zhou, S. Xu, and Q. Wu. “SU-E-T-252: Developing a Pencil Beam Dose Calculation Algorithm for CyberKnife System.” Med Phys 42, no. 6 (June 2015): 3390. https://doi.org/10.1118/1.4924614.
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  - Rodrigues, A., B. Liang, F. Yin, and Q. Wu. “TU-CD-304-07: Intensity Modulated Electron Beam Therapy Employing Small Fields in Virtual Scanning Mode.” Med Phys 42, no. 6 (June 2015): 3600. https://doi.org/10.1118/1.4925576.
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  - Rodrigues, A., F. Yin, and Q. Wu. “SU-E-T-344: Dynamic Electron Beam Therapy Using Multiple Apertures in a Single Cut-Out.” Med Phys 42, no. 6 (June 2015): 3412. https://doi.org/10.1118/1.4924705.
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  - Wu, Q. “WE-A-207-02: Electron Beam Therapy - Current Status and Future Directions.” Med Phys 42, no. 6 (June 2015): 3662. https://doi.org/10.1118/1.4925891.
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  - Rodrigues, Anna, Daren Sawkey, Fang-Fang Yin, and Qiuwen Wu. “A Monte Carlo simulation framework for electron beam dose calculations using Varian phase space files for TrueBeam Linacs.” Med Phys 42, no. 5 (May 2015): 2389–2403. https://doi.org/10.1118/1.4916896.
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  - Li, Taoran, Qiuwen Wu, Yun Yang, Anna Rodrigues, Fang-Fang Yin, and Q. Jackie Wu. “Quality assurance for online adapted treatment plans: benchmarking and delivery monitoring simulation.” Med Phys 42, no. 1 (January 2015): 381–90. https://doi.org/10.1118/1.4904021.
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  - Li, X Allen, Qiuwen Wu, and Colin G. Orton. “Point/Counterpoint. Online adaptive planning for prostate cancer radiotherapy is necessary and ready now.” Med Phys 41, no. 8 (August 2014): 080601. https://doi.org/10.1118/1.4883875.
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  - Yuan, Lulin, Q Jackie Wu, Fang-Fang Yin, Yuliang Jiang, David Yoo, and Yaorong Ge. “Incorporating single-side sparing in models for predicting parotid dose sparing in head and neck IMRT.” Med Phys 41, no. 2 (February 2014): 021728. https://doi.org/10.1118/1.4862075.
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  - Rodrigues, Anna, Fang-Fang Yin, and Qiuwen Wu. “Dynamic electron arc radiotherapy (DEAR): a feasibility study.” Phys Med Biol 59, no. 2 (January 20, 2014): 327–45. https://doi.org/10.1088/0031-9155/59/2/327.
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  - Li, Taoran, Qiuwen Wu, You Zhang, Irina Vergalasova, W Robert Lee, Fang-Fang Yin, and Q Jackie Wu. “Strategies for automatic online treatment plan reoptimization using clinical treatment planning system: a planning parameters study.” Med Phys 40, no. 11 (November 2013): 111711. https://doi.org/10.1118/1.4823473.
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  - Liu, Bo, Justus Adamson, Anna Rodrigues, Fugen Zhou, Fang-fang Yin, and Qiuwen Wu. “A novel technique for VMAT QA with EPID in cine mode on a Varian TrueBeam linac.” Phys Med Biol 58, no. 19 (October 7, 2013): 6683–6700. https://doi.org/10.1088/0031-9155/58/19/6683.
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  - Chang, Z., Q. Wu, H. Yan, Y. Yang, W. Giles, C. Busselberg, R. Lipscomb, and F. Yin. “SU-E-T-143: Dosimetric Characteristics of TrueBeam STx System with High Definition Multi-Leaf Collimator: Commissioning of Stereotactic Radiosurgery.” Med Phys 40, no. 6Part12 (June 2013): 236–37. https://doi.org/10.1118/1.4814578.
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  - Liu, B., J. Adamson, A. Rodrigues, F. Zhou, F. Yin, and Q. Wu. “WE-G-108-08: A Novel Technique for VMAT QA with EPID in Cine Mode On Varian TrueBeam.” Med Phys 40, no. 6Part30 (June 2013): 502. https://doi.org/10.1118/1.4815632.
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  - Rodrigues, A., F. Yin, and Q. Wu. “SU-E-T-602: Dynamic Electron Arc Radiotherapy (DEAR): A Planning Study.” Med Phys 40, no. 6Part20 (June 2013): 344. https://doi.org/10.1118/1.4815030.
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  - Sawkey, D., M. Constantin, S. Mansfield, J. Star-Lack, A. Rodrigues, Q. Wu, and M. Svatos. “SU-E-T-553: Measurement of Incident Electron Spots On TrueBeam.” Med Phys 40, no. 6Part19 (June 2013): 332. https://doi.org/10.1118/1.4814982.
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  - Wu, Q., and H. Liu. “Adaptive dose-compensation technique for image-guided radiotherapy of prostate cancer.” Ifmbe Proceedings 39 IFMBE (April 16, 2013): 1864–67. https://doi.org/10.1007/978-3-642-29305-4_491.
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  - Chang, Zheng, Qiuwen Wu, Justus Adamson, Lei Ren, James Bowsher, Hui Yan, Andrew Thomas, and Fang-Fang Yin. “Commissioning and dosimetric characteristics of TrueBeam system: composite data of three TrueBeam machines.” Med Phys 39, no. 11 (November 2012): 6981–7018. https://doi.org/10.1118/1.4762682.
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  - Adamson, Justus, and Qiuwen Wu. “Independent verification of gantry angle for pre-treatment VMAT QA using EPID.” Phys Med Biol 57, no. 20 (October 21, 2012): 6587–6600. https://doi.org/10.1088/0031-9155/57/20/6587.
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  - Gopan, Olga, and Qiuwen Wu. “Evaluation of the accuracy of a 3D surface imaging system for patient setup in head and neck cancer radiotherapy.” Int J Radiat Oncol Biol Phys 84, no. 2 (October 1, 2012): 547–52. https://doi.org/10.1016/j.ijrobp.2011.12.004.
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  - Chang, Z., Q. Wu, J. Adamson, L. Ren, J. Bowsher, H. Yan, A. Thomas, and F. Yin. “SU-E-T-104: Commissioning and Dosimetric Characteristics of TrueBeam System: Composite Data of Three TrueBeam Machines.” Med Phys 39, no. 6Part11 (June 2012): 3726. https://doi.org/10.1118/1.4735162.
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  - Li, T., L. Yuan, Q. Wu, F. Yin, and Q. J. Wu. “MO-D-BRB-09: Treatment Delivery QA for Online Adaptive Radiation Therapy Based on Dynamic Machine Information (DMI): A Feasibility Study.” Med Phys 39, no. 6Part21 (June 2012): 3867–68. https://doi.org/10.1118/1.4735790.
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  - Song, H., J. Salama, D. Yoo, J. Oleson, and Q. Wu. “SU-E-J-23: Prostate Bed Motion Study Using Surgical Clips Based on Daily CBCT.” Med Phys 39, no. 6Part6 (June 2012): 3657. https://doi.org/10.1118/1.4734856.
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  - Wu, Q., S. Yoo, S. Das, and F. Yin. “SU-E-T-559: Evaluation of Flatening Filter Free (FFF) Beams in Radiotherapy of Head and Neck Cancer.” Med Phys 39, no. 6Part19 (June 2012): 3834. https://doi.org/10.1118/1.4735648.
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  - Xu, Z., T. Li, W. Lee, R. Hood, D. Godfrey, and Q. Wu. “SU-E-J-16: Prostate Bed Motion during Post-Prostatectomy Radiotherapy.” Med Phys 39, no. 6Part6 (June 2012): 3655. https://doi.org/10.1118/1.4734849.
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  - Yoo, Sua, Qiuwen Wu, Jennifer O’Daniel, Janet Horton, and Fang-Fang Yin. “Comparison of 3D conformal breast radiation treatment plans using the anisotropic analytical algorithm and pencil beam convolution algorithm.” Radiother Oncol 103, no. 2 (May 2012): 172–77. https://doi.org/10.1016/j.radonc.2012.01.010.
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  - Liu, Han, and Qiuwen Wu. “A "rolling average" multiple adaptive planning method to compensate for target volume changes in image-guided radiotherapy of prostate cancer.” J Appl Clin Med Phys 13, no. 1 (January 5, 2012): 3697. https://doi.org/10.1120/jacmp.v13i1.3697.
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  - Liu, Han, and Qiuwen Wu. “Evaluations of an adaptive planning technique incorporating dose feedback in image-guided radiotherapy of prostate cancer.” Med Phys 38, no. 12 (December 2011): 6362–70. https://doi.org/10.1118/1.3658567.
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  - Wu, Q., and H. Liu. “The Role of Offline Adaptive Planning in Online Image Guided Radiation Therapy of Prostate Cancer.” International Journal of Radiation Oncology*Biology*Physics 81, no. 2 (October 2011): S836–S836. https://doi.org/10.1016/j.ijrobp.2011.06.1479.
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  - Liu, Han, and Qiuwen Wu. “Dosimetric and geometric evaluation of a hybrid strategy of offline adaptive planning and online image guidance for prostate cancer radiotherapy.” Phys Med Biol 56, no. 15 (August 7, 2011): 5045–62. https://doi.org/10.1088/0031-9155/56/15/024.
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  - Adamson, Justus, Qiuwen Wu, and Di Yan. “Dosimetric effect of intrafraction motion and residual setup error for hypofractionated prostate intensity-modulated radiotherapy with online cone beam computed tomography image guidance.” Int J Radiat Oncol Biol Phys 80, no. 2 (June 1, 2011): 453–61. https://doi.org/10.1016/j.ijrobp.2010.02.033.
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  - Wu, Qingrong Jackie, Taoran Li, Qiuwen Wu, and Fang-Fang Yin. “Adaptive radiation therapy: technical components and clinical applications.” Cancer J 17, no. 3 (May 2011): 182–89. https://doi.org/10.1097/PPO.0b013e31821da9d8.
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  - Adamson, Justus, and Qiuwen Wu. “Prostate intrafraction motion assessed by simultaneous kilovoltage fluoroscopy at megavoltage delivery I: clinical observations and pattern analysis.” Int J Radiat Oncol Biol Phys 78, no. 5 (December 1, 2010): 1563–70. https://doi.org/10.1016/j.ijrobp.2009.09.027.
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  - Adamson, Justus, and Qiuwen Wu. “Prostate intrafraction motion assessed by simultaneous kV fluoroscopy at MV delivery II: adaptive strategies.” Int J Radiat Oncol Biol Phys 78, no. 5 (December 1, 2010): 1323–30. https://doi.org/10.1016/j.ijrobp.2009.09.079.
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  - Zhuang, Tingliang, and Qiuwen Wu. “Generating arbitrary one-dimensional dose profiles using rotational therapy.” Phys Med Biol 55, no. 20 (October 21, 2010): 6263–77. https://doi.org/10.1088/0031-9155/55/20/014.
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  - Worthy, Danielle, and Qiuwen Wu. “Dosimetric assessment of rigid setup error by CBCT for HN-IMRT.” J Appl Clin Med Phys 11, no. 3 (May 28, 2010): 3187. https://doi.org/10.1120/jacmp.v11i3.3187.
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  - Lei, Yu, and Qiuwen Wu. “A hybrid strategy of offline adaptive planning and online image guidance for prostate cancer radiotherapy.” Phys Med Biol 55, no. 8 (April 21, 2010): 2221–34. https://doi.org/10.1088/0031-9155/55/8/007.
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  - Li, Taoran, Xiaofeng Zhu, Danthai Thongphiew, W Robert Lee, Zeljko Vujaskovic, Qiuwen Wu, Fang-Fang Yin, and Q Jackie Wu. “On-line adaptive radiation therapy: feasibility and clinical study.” J Oncol 2010 (2010): 407236. https://doi.org/10.1155/2010/407236.
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  - Wang, Weihu, Qiuwen Wu, and Di Yan. “Quantitative evaluation of cone-beam computed tomography in target volume definition for offline image-guided radiation therapy of prostate cancer.” Radiother Oncol 94, no. 1 (January 2010): 71–75. https://doi.org/10.1016/j.radonc.2009.10.005.
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  - Worthy, D., and Q. Wu. “Dosimetric assessment of rigid setup error by CBCT for HN-IMRT.” Journal of Applied Clinical Medical Physics 11, no. 3 (January 1, 2010): 38–53. https://doi.org/10.1120/jacmp.v11i3.3187.
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  - Yin, Fang-Fang, Mark Oldham, Jing Cai, and Qiuwen Wu. “Dosimetry challenges for implementing emerging technologies.” J Phys Conf Ser 250, no. 1 (2010): 8–11. https://doi.org/10.1088/1742-6596/250/1/012002.
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  - Wu, Qiuwen, Yuwei Chi, Peter Y. Chen, Daniel J. Krauss, Di Yan, and Alvaro Martinez. “Adaptive replanning strategies accounting for shrinkage in head and neck IMRT.” Int J Radiat Oncol Biol Phys 75, no. 3 (November 1, 2009): 924–32. https://doi.org/10.1016/j.ijrobp.2009.04.047.
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  - Adamson, Justus, and Qiuwen Wu. “Inferences about prostate intrafraction motion from pre- and posttreatment volumetric imaging.” Int J Radiat Oncol Biol Phys 75, no. 1 (September 1, 2009): 260–67. https://doi.org/10.1016/j.ijrobp.2009.03.007.
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  - Worthy, Danielle, and Qiuwen Wu. “Parameter optimization in HN-IMRT for Elekta linacs.” J Appl Clin Med Phys 10, no. 2 (April 28, 2009): 2951. https://doi.org/10.1120/jacmp.v10i2.2951.
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  - Song, Haijun, Zhe Chen, Ning Yue, Qingrong Wu, and Fang-Fang Yin. “Ice as a water-equivalent solid medium for brachytherapy dosimetric measurements.” Radiat Environ Biophys 48, no. 2 (April 2009): 145–51. https://doi.org/10.1007/s00411-008-0205-9.
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  - Liang, Jian, Qiuwen Wu, and Di Yan. “The role of seminal vesicle motion in target margin assessment for online image-guided radiotherapy for prostate cancer.” Int J Radiat Oncol Biol Phys 73, no. 3 (March 1, 2009): 935–43. https://doi.org/10.1016/j.ijrobp.2008.10.019.
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  - Adamson, Justus, and Qiuwen Wu. “Optimizing monoscopic kV fluoro acquisition for prostate intrafraction motion evaluation.” Phys Med Biol 54, no. 1 (January 7, 2009): 117–33. https://doi.org/10.1088/0031-9155/54/1/008.
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  - Worthy, D., and Q. Wu. “Parameter optimization in HN-IMRT for Elekta linacs.” Journal of Applied Clinical Medical Physics 10, no. 2 (January 1, 2009): 43–61. https://doi.org/10.1120/jacmp.v10i2.2951.
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  - Adamson, Justus, and Qiuwen Wu. “Prostate intrafraction motion evaluation using kV fluoroscopy during treatment delivery: a feasibility and accuracy study.” Med Phys 35, no. 5 (May 2008): 1793–1806. https://doi.org/10.1118/1.2899998.
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  - Godfrey, Devon J., Lei Ren, Hui Yan, Q. Wu, Sua Yoo, M. Oldham, and Fang Fang Yin. “Evaluation of three types of reference image data for external beam radiotherapy target localization using digital tomosynthesis (DTS).” Med Phys 34, no. 8 (August 2007): 3374–84. https://doi.org/10.1118/1.2756941.
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  - Wu, Qiuwen, David Lockman, John Wong, and Di Yan. “Effect of the first day correction on systematic setup error reduction.” Med Phys 34, no. 5 (May 2007): 1789–96. https://doi.org/10.1118/1.2727299.
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  - Adamson, J., and Q. wu. “WE‐E‐M100F‐07: Prostate Intrafraction Motion Measurement Using KV Fluoroscopy During Treatment Delivery.” Medical Physics 34, no. 6 (January 1, 2007): 2608–9. https://doi.org/10.1118/1.2761589.
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  - Liang, J., Q. wu, and D. Yan. “SU‐FF‐J‐64: The Role of Seminal Vesicle Motion in Target Margin Assessment for Online Image Guided Prostate Cancer Radiotherapy.” Medical Physics 34, no. 6 (January 1, 2007): 2382–83. https://doi.org/10.1118/1.2760569.
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  - wu, Q., Y. Chi, J. Wloch, and D. Yan. “SU‐FF‐J‐73: Non‐Rigid Setup Errors in HN‐IMRT Patients and Their Dosimetric Effect.” Medical Physics 34, no. 6 (January 1, 2007): 2385. https://doi.org/10.1118/1.2760578.
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  - Djajaputra, David, and Qiuwen Wu. “On relating the generalized equivalent uniform dose formalism to the linear-quadratic model.” Med Phys 33, no. 12 (December 2006): 4481–89. https://doi.org/10.1118/1.2369469.
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  - Wu, Qiuwen, Giovanni Ivaldi, Jian Liang, David Lockman, Di Yan, and Alvaro Martinez. “Geometric and dosimetric evaluations of an online image-guidance strategy for 3D-CRT of prostate cancer.” Int J Radiat Oncol Biol Phys 64, no. 5 (April 1, 2006): 1596–1609. https://doi.org/10.1016/j.ijrobp.2005.12.029.
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  - Wu, Qiuwen, Jian Liang, and Di Yan. “Application of dose compensation in image-guided radiotherapy of prostate cancer.” Phys Med Biol 51, no. 6 (March 21, 2006): 1405–19. https://doi.org/10.1088/0031-9155/51/6/003.
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  - Sakthi, Nirmal, Paul Keall, Ivaylo Mihaylov, Qiuwen Wu, Yan Wu, Jeffrey F. Williamson, Rupert Schmidt-Ullrich, and Jeffrey V. Siebers. “Monte Carlo-based dosimetry of head-and-neck patients treated with SIB-IMRT.” Int J Radiat Oncol Biol Phys 64, no. 3 (March 1, 2006): 968–77. https://doi.org/10.1016/j.ijrobp.2005.09.049.
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  - Siebers, Jeffrey V., Paul J. Keall, Qiuwen Wu, Jeffrey F. Williamson, and Rupert K. Schmidt-Ullrich. “Effect of patient setup errors on simultaneously integrated boost head and neck IMRT treatment plans.” Int J Radiat Oncol Biol Phys 63, no. 2 (October 1, 2005): 422–33. https://doi.org/10.1016/j.ijrobp.2005.02.029.
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  - Wu, Qiuwen, David Djajaputra, Helen H. Liu, Lei Dong, Radhe Mohan, and Yan Wu. “Dose sculpting with generalized equivalent uniform dose.” Med Phys 32, no. 5 (May 2005): 1387–96. https://doi.org/10.1118/1.1897464.
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  - wu, Q., J. Liang, and D. Yan. “SU‐EE‐A3‐02: Feasibility Study of Dose Compensation in Image‐Guided Radiotherapy (IGRT) of Prostate Cancer.” Medical Physics 32, no. 6 (January 1, 2005): 1899. https://doi.org/10.1118/1.1997460.
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  - Wang, Xiaochun, Xiaodong Zhang, Lei Dong, Helen Liu, Qiuwen Wu, and Radhe Mohan. “Development of methods for beam angle optimization for IMRT using an accelerated exhaustive search strategy.” Int J Radiat Oncol Biol Phys 60, no. 4 (November 15, 2004): 1325–37. https://doi.org/10.1016/j.ijrobp.2004.06.007.
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  - Wu, Qiuwen. “A dose calculation method including scatter for IMRT optimization.” Phys Med Biol 49, no. 19 (October 7, 2004): 4611–21. https://doi.org/10.1088/0031-9155/49/19/011.
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  - Lauve, Andrew, Monica Morris, Rupert Schmidt-Ullrich, Qiuwen Wu, Radhe Mohan, Olubumni Abayomi, David Buck, et al. “Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head-and-neck squamous cell carcinomas: II--clinical results.” Int J Radiat Oncol Biol Phys 60, no. 2 (October 1, 2004): 374–87. https://doi.org/10.1016/j.ijrobp.2004.03.010.
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  - Zhang, Xiaodong, Helen Liu, Xiaochun Wang, Lei Dong, Qiuwen Wu, and Radhe Mohan. “Speed and convergence properties of gradient algorithms for optimization of IMRT.” Med Phys 31, no. 5 (May 2004): 1141–52. https://doi.org/10.1118/1.1688214.
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  - Liu, H Helen, Xiaochun Wang, Lei Dong, Qiuwen Wu, Zhongxing Liao, Craig W. Stevens, Thomas M. Guerrero, Ritsuko Komaki, James D. Cox, and Radhe Mohan. “Feasibility of sparing lung and other thoracic structures with intensity-modulated radiotherapy for non-small-cell lung cancer.” Int J Radiat Oncol Biol Phys 58, no. 4 (March 15, 2004): 1268–79. https://doi.org/10.1016/j.ijrobp.2003.09.085.
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  - Zhou, Jining, Dingyu Fei, and Qiuwen Wu. “Potential of intensity-modulated radiotherapy to escalate doses to head-and-neck cancers: what is the maximal dose?” Int J Radiat Oncol Biol Phys 57, no. 3 (November 1, 2003): 673–82. https://doi.org/10.1016/s0360-3016(03)00626-6.
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  - Djajaputra, David, Qiuwen Wu, Yan Wu, and Radhe Mohan. “Algorithm and performance of a clinical IMRT beam-angle optimization system.” Phys Med Biol 48, no. 19 (October 7, 2003): 3191–3212. https://doi.org/10.1088/0031-9155/48/19/007.
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  - Wu, Qiuwen, David Djajaputra, Marc Lauterbach, Yan Wu, and Radhe Mohan. “A fast dose calculation method based on table lookup for IMRT optimization.” Phys Med Biol 48, no. 12 (June 21, 2003): N159–66. https://doi.org/10.1088/0031-9155/48/12/401.
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  - Wu, Qiuwen, Radhe Mohan, Monica Morris, Andrew Lauve, and Rupert Schmidt-Ullrich. “Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head-and-neck squamous cell carcinomas. I: dosimetric results.” Int J Radiat Oncol Biol Phys 56, no. 2 (June 1, 2003): 573–85. https://doi.org/10.1016/s0360-3016(02)04617-5.
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  - George, R., P. J. Keall, V. R. Kini, S. S. Vedam, J. V. Siebers, Q. Wu, M. H. Lauterbach, D. W. Arthur, and R. Mohan. “Quantifying the effect of intrafraction motion during breast IMRT planning and dose delivery.” Med Phys 30, no. 4 (April 2003): 552–62. https://doi.org/10.1118/1.1543151.
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  - Kavanagh, B. D., R. D. Timmerman, S. H. Benedict, Q. Wu, T. E. Schefter, K. Stuhr, S. McCourt, F. Newman, R. M. Cardinale, and L. F. Gaspar. “How should we describe the radioblologic effect of extracranial stereotactic radlosurgery: equivalent uniform dose or tumor control probability?” Med Phys 30, no. 3 (March 2003): 321–24. https://doi.org/10.1118/1.1543571.
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  - Wu, Qiuwen, David Djajaputra, Yan Wu, Jining Zhou, Helen H. Liu, and Radhe Mohan. “Intensity-modulated radiotherapy optimization with gEUD-guided dose-volume objectives.” Phys Med Biol 48, no. 3 (February 7, 2003): 279–91. https://doi.org/10.1088/0031-9155/48/3/301.
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  - Kavanagh, Brian D., Tracey E. Schefter, Qiuwen Wu, Shidong Tong, Francis Newman, Mark Arnfield, Stanley H. Benedict, Steve McCourt, and Radhe Mohan. “Clinical application of intensity-modulated radiotherapy for locally advanced cervical cancer.” Semin Radiat Oncol 12, no. 3 (July 2002): 260–71. https://doi.org/10.1053/srao.2002.32471.
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  - Wu, Qiuwen, and Radhe Mohan. “Multiple local minima in IMRT optimization based on dose-volume criteria.” Med Phys 29, no. 7 (July 2002): 1514–27. https://doi.org/10.1118/1.1485059.
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  - Siebers, Jeffrey V., Marc Lauterbach, Shidong Tong, Qiuwen Wu, and Radhe Mohan. “Reducing dose calculation time for accurate iterative IMRT planning.” Med Phys 29, no. 2 (February 2002): 231–37. https://doi.org/10.1118/1.1446112.
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  - Schefter, Tracey E., Brian D. Kavanagh, Qiuwen Wu, Shidong Tong, Francis Newman, Steve Mccourt, Mark Arnfield, Stanley Benedict, and Radhe Mohan. “Technical considerations in the application of intensity-modulated radiotherapy as a concomitant integrated boost for locally-advanced cervix cancer.” Med Dosim 27, no. 2 (2002): 177–84. https://doi.org/10.1016/s0958-3947(02)00101-2.
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  - Wu, Qiuwen, Radhe Mohan, Andrzej Niemierko, and Rupert Schmidt-Ullrich. “Optimization of intensity-modulated radiotherapy plans based on the equivalent uniform dose.” Int J Radiat Oncol Biol Phys 52, no. 1 (January 1, 2002): 224–35. https://doi.org/10.1016/s0360-3016(01)02585-8.
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  - Manning, M. A., Q. Wu, R. M. Cardinale, R. Mohan, A. D. Lauve, B. D. Kavanagh, M. M. Morris, and R. K. Schmidt-Ullrich. “The effect of setup uncertainty on normal tissue sparing with IMRT for head-and-neck cancer.” Int J Radiat Oncol Biol Phys 51, no. 5 (December 1, 2001): 1400–1409. https://doi.org/10.1016/s0360-3016(01)01740-0.
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  - Benedict, S. H., R. M. Cardinale, Q. Wu, R. D. Zwicker, W. C. Broaddus, and R. Mohan. “Intensity-modulated stereotactic radiosurgery using dynamic micro-multileaf collimation.” Int J Radiat Oncol Biol Phys 50, no. 3 (July 1, 2001): 751–58. https://doi.org/10.1016/s0360-3016(01)01487-0.
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  - Siebers, J. V., S. Tong, M. Lauterbach, Q. Wu, and R. Mohan. “Acceleration of dose calculations for intensity-modulated radiotherapy.” Med Phys 28, no. 6 (June 2001): 903–10. https://doi.org/10.1118/1.1373404.
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  - Arnfield, M. R., Q. Wu, S. Tong, and R. Mohan. “Dosimetric validation for multileaf collimator-based intensity-modulated radiotherapy: a review.” Med Dosim 26, no. 2 (2001): 179–88. https://doi.org/10.1016/s0958-3947(01)00058-9.
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  - Mohan, R., R. M. Cardinale, Q. Wu, and S. Benedict. “Intensity-modulated stereotactic radiosurgery.” Frontiers of Radiation Therapy and Oncology 34 (December 1, 2000): 40–48.
  - Arnfield, M. R., J. V. Siebers, J. O. Kim, Q. Wu, P. J. Keall, and R. Mohan. “A method for determining multileaf collimator transmission and scatter for dynamic intensity modulated radiotherapy.” Med Phys 27, no. 10 (October 2000): 2231–41. https://doi.org/10.1118/1.1312190.
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  - Wu, Q., M. Arnfield, S. Tong, Y. Wu, and R. Mohan. “Dynamic splitting of large intensity-modulated fields.” Phys Med Biol 45, no. 7 (July 2000): 1731–40. https://doi.org/10.1088/0031-9155/45/7/302.
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  - Mohan, R., M. Arnfield, S. Tong, Q. Wu, and J. Siebers. “The impact of fluctuations in intensity patterns on the number of monitor units and the quality and accuracy of intensity modulated radiotherapy.” Med Phys 27, no. 6 (June 2000): 1226–37. https://doi.org/10.1118/1.599000.
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  - Wu, Q., and R. Mohan. “Algorithms and functionality of an intensity modulated radiotherapy optimization system.” Med Phys 27, no. 4 (April 2000): 701–11. https://doi.org/10.1118/1.598932.
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  - Mohan, R., Q. Wu, M. Manning, and R. Schmidt-Ullrich. “Radiobiological considerations in the design of fractionation strategies for intensity-modulated radiation therapy of head and neck cancers.” Int J Radiat Oncol Biol Phys 46, no. 3 (February 1, 2000): 619–30. https://doi.org/10.1016/s0360-3016(99)00438-1.
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  - Wu, Q., M. Manning, R. Schmidt-Ullrich, and R. Mohan. “The potential for sparing of parotids and escalation of biologically effective dose with intensity-modulated radiation treatments of head and neck cancers: a treatment design study.” Int J Radiat Oncol Biol Phys 46, no. 1 (January 1, 2000): 195–205. https://doi.org/10.1016/s0360-3016(99)00304-1.
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  - Wu, Q., R. Mohan, and A. Niemierko. “IMRT optimization based on the generalized equivalent uniform dose (EUD).” Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings 1 (January 1, 2000): 710–13. https://doi.org/10.1109/IEMBS.2000.900845.
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  - Cardinale, R. M., Q. Wu, S. H. Benedict, B. D. Kavanagh, E. Bump, and R. Mohan. “Determining the optimal block margin on the planning target volume for extracranial stereotactic radiotherapy.” Int J Radiat Oncol Biol Phys 45, no. 2 (September 1, 1999): 515–20. https://doi.org/10.1016/s0360-3016(99)00203-5.
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  - Cardinale, R. M., S. H. Benedict, Q. Wu, R. D. Zwicker, H. E. Gaballa, and R. Mohan. “A comparison of three stereotactic radiotherapy techniques; ARCS vs. noncoplanar fixed fields vs. intensity modulation.” Int J Radiat Oncol Biol Phys 42, no. 2 (September 1, 1998): 431–36. https://doi.org/10.1016/s0360-3016(98)00206-5.
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  - Mohan, R., G. Mageras, and Q. Wu. “Computer-controlled delivery of 3D conformal radiation treatments.” Cancer Treat Res 93 (1998): 49–67. https://doi.org/10.1007/978-1-4615-5769-2_3.
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  - Burman, C., C. S. Chui, G. Kutcher, S. Leibel, M. Zelefsky, T. LoSasso, S. Spirou, et al. “Planning, delivery, and quality assurance of intensity-modulated radiotherapy using dynamic multileaf collimator: a strategy for large-scale implementation for the treatment of carcinoma of the prostate.” Int J Radiat Oncol Biol Phys 39, no. 4 (November 1, 1997): 863–73. https://doi.org/10.1016/s0360-3016(97)00458-6.
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  - Stein, J., R. Mohan, X. H. Wang, T. Bortfeld, Q. Wu, K. Preiser, C. C. Ling, and W. Schlegel. “Number and orientations of beams in intensity-modulated radiation treatments.” Med Phys 24, no. 2 (February 1997): 149–60. https://doi.org/10.1118/1.597923.
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  - Mohan, R., Q. Wu, X. Wang, and J. Stein. “Intensity modulation optimization, lateral transport of radiation, and margins.” Med Phys 23, no. 12 (December 1996): 2011–21. https://doi.org/10.1118/1.597848.
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  - Ling, C. C., C. Burman, C. S. Chui, G. J. Kutcher, S. A. Leibel, T. LoSasso, R. Mohan, et al. “Conformal radiation treatment of prostate cancer using inversely-planned intensity-modulated photon beams produced with dynamic multileaf collimation.” Int J Radiat Oncol Biol Phys 35, no. 4 (July 1, 1996): 721–30. https://doi.org/10.1016/0360-3016(96)00174-5.
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- Conference Papers
  - Desmal, A. A., Y. Sheng, H. Stephens, Y. Ge, Q. Wu, and J. Wu. “Two Photon Dose Engines for Accurate and Fast Volumetric Modulated Arc Therapy.” In 2019 Advances in Science and Engineering Technology International Conferences, Aset 2019, 2019. https://doi.org/10.1109/ICASET.2019.8714322.
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  - Wu, Q., A. Rodrigues, and F. Yin. “Dynamic Electron Arc Radiation Therapy (DEAR): A New Conformal Technique in Delivering Electron Beam Therapy.” In International Journal of Radiation Oncology*Biology*Physics, 87:S121–S121. Elsevier BV, 2013. https://doi.org/10.1016/j.ijrobp.2013.06.311.
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  - Wu, Q., Z. Chang, J. Adamson, L. Ren, and F. Yin. “SU-E-T-560: A Method to Determine Optimal Dynamic MLC Parameters for Varian Truebeam with Millennium MLC and HDMLC.” In Med Phys, 40:334, 2013. https://doi.org/10.1118/1.4814989.
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  - Rodrigues, A., F. Yin, and Q. wu. “TU‐E‐108‐02: Dynamic Electron Arc Radiotherapy (DEAR): A Feasibility Study.” In Medical Physics, 40:443, 2013. https://doi.org/10.1118/1.4815417.
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  - Chen, Q., J. Cai, Q. Wu, and F. Yin. “Dosimetric Evaluation of Flattening Filter-free (FFF) Photon Beams for Lung SBRT.” In International Journal of Radiation Oncology*Biology*Physics, 84:S609–S609. Elsevier BV, 2012. https://doi.org/10.1016/j.ijrobp.2012.07.1623.
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  - Song, H., J. Salama, D. Yoo, J. Oleson, and Q. Wu. “Study of Prostate Bed Motion Using Daily CBCT and Surgical Clips.” In International Journal of Radiation Oncology*Biology*Physics, 84:S741–42. Elsevier BV, 2012. https://doi.org/10.1016/j.ijrobp.2012.07.1983.
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  - Wu, Q., S. Yoo, S. Das, and F. Yin. “Evaluation of IMRT and VMAT for Head-and-Neck Cancer With Flattening Filter-free (FFF) Beams.” In International Journal of Radiation Oncology*Biology*Physics, 84:S863–S863. Elsevier BV, 2012. https://doi.org/10.1016/j.ijrobp.2012.07.2308.
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  - Yoo, S., J. O’Daniel, R. Blitzblau, Q. Wu, F. Yin, and J. Horton. “Partial Breast Extracranial Radiosurgery: A Dosimetric Evaluation of Treatment Delivery Accuracy.” In International Journal of Radiation Oncology*Biology*Physics, 84:S243–S243. Elsevier BV, 2012. https://doi.org/10.1016/j.ijrobp.2012.07.631.
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  - Ashmeg, S., J. O’Daniel, Q. Wu, and F. Yin. “Benchmarking Flattening-Filter Free Photons for IMRT/VMAT.” In Medical Physics, 39:4011–4011, 2012. https://doi.org/10.1118/1.4736361.
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  - Chang, Z., Q. Wu, J. Adamson, L. Ren, J. Bowsher, H. Yan, A. Thomas, and F. Yin. “Assessing Effects of Ion Collection Efficiency in Flattening Filter-Free (FFF) Beams On Three TrueBeam Machines.” In Medical Physics, 39:3719–3719, 2012. https://doi.org/10.1118/1.4735130.
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  - Adamson, J., and Q. wu. “WE‐E‐BRB‐07: EPID Based Verification of Delivered Fluence for VMAT with High Angular Resolution.” In Medical Physics, 38:3817, 2011. https://doi.org/10.1118/1.3613374.
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  - Galvin, J., F. Yin, Q. wu, and Y. Xiao. “WE‐E‐301‐01: Practical Tips for VMAT Implementation.” In Medical Physics, 38:3823, 2011. https://doi.org/10.1118/1.3613395.
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  - wu, Q., and H. Liu. “SU‐E‐T‐782: A Novel Geometric Index to Evaluate Image Guidance Strategies for Prostate Cancer Adaptive Radiotherapy.” In Medical Physics, 38:3671, 2011. https://doi.org/10.1118/1.3612746.
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  - Adamson, J. D., S. Yoo, Q. Wu, and F. Yin. “Variation of Clinically Relevant Dose Indices for 3DCRT of Lung with Respect to Dose Calculation Algorithm.” In International Journal of Radiation Oncology*Biology*Physics, 78:S712–13. Elsevier BV, 2010. https://doi.org/10.1016/j.ijrobp.2010.07.1652.
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  - Yoo, S., Q. Wu, J. O’Daniel, J. Horton, and F. Yin. “Breast Cancer Radiation Treatment Planning: A Comparison of Anisotropic Analytical Algorithm (AAA) and Pencil Beam Convolution (PBC) Algorithm.” In International Journal of Radiation Oncology*Biology*Physics, 78:S240–S240. Elsevier BV, 2010. https://doi.org/10.1016/j.ijrobp.2010.07.574.
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  - Adamson, J. D., Q. Wu, and D. Yan. “Adaptive Management of Intrafraction Motion in Online Image Guided Prostate Cancer Radiotherapy.” In International Journal of Radiation Oncology*Biology*Physics, 75:S628–29. Elsevier BV, 2009. https://doi.org/10.1016/j.ijrobp.2009.07.1436.
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  - Adamson, J., Q. wu, and D. Yan. “TU‐C‐303A‐08: A Hybrid Strategy Using Discriminant Analysis for Prostate Intrafraction Motion Management.” In Medical Physics, 36:2726, 2009. https://doi.org/10.1118/1.3182345.
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  - Thongphiew, D., X. Zhu, Q. wu, and F. Yin. “SU‐FF‐T‐80: Hybrid Image Guided Radiation Therapy for Hypofractionated Prostate IMRT: Feasibility Study.” In Medical Physics, 36:2537–38, 2009. https://doi.org/10.1118/1.3181553.
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  - Wu, Q., and J. Adamson. “SU‐FF‐T‐620: Assessment of Dose Reconstruction Methods for Prostate Image Guided Radiotherapy Protocols.” In Medical Physics, 36:2667, 2009. https://doi.org/10.1118/1.3182118.
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  - Adamson, J., and Q. Wu. “TU‐FF‐A3‐05: Optimizing KV Fluoro Acquisition for Prostate Intrafraction Motion Evaluation.” In Medical Physics, 35:2922, 2008. https://doi.org/10.1118/1.2962654.
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  - Adamson, J., and Q. wu. “TU‐C‐351‐03: Can Pre‐ and Post‐Imaging Determine Prostate Intrafraction Motion?” In Medical Physics, 35:2891, 2008. https://doi.org/10.1118/1.2962462.
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  - wu, Q., E. Meldolesi, P. Chen, and D. Yan. “SU‐FF‐J‐51: Dosimetric Evaluations of Organs at Risk for Head and Neck Cancer Patients During Entire IMRT Treatment Course.” In Medical Physics, 33:2032, 2006. https://doi.org/10.1118/1.2240829.
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  - wu, Q., J. Wloch, J. Fayad, and D. Yan. “TU‐C‐ValB‐09: Setup Error Analysis of HN‐IMRT Patients Using Electronic Portal Images and Cone‐Beam CTs.” In Medical Physics, 33:2189, 2006. https://doi.org/10.1118/1.2241521.
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