Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Cardiothoracic Anesthesiology Fellowship, Anesthesiology, Duke University School of Medicine 2014 - 2015
  • Residency, Anesthesiology, Duke University School of Medicine 2011 - 2014
  • Internship, Anesthesiology, Duke University School of Medicine 2010 - 2011
  • M.D., Duke University School of Medicine 2010
  • M.S., Duke University 2008
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Anesthesiology, Anesthesiology, Cardiothoracic, Anesthesiology 2015 - 2021
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Mamoun, Negmeldeen, Mary Cooter Wright, Brandi Bottiger, Ryan Plichta, Rebecca Klinger, Michael Manning, Karthik Raghunathan, and Padma Gulur. “Pain Trajectories After Valve Surgeries Performed via Midline Sternotomy Versus Mini-Thoracotomy.” J Cardiothorac Vasc Anesth, May 10, 2022. https://doi.org/10.1053/j.jvca.2022.05.007.
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    • Belani, Kiran, Christina E. Saikus, Jacob N. Schroder, and Rebecca Y. Klinger. “Transapical ProtekDuo Rapid Deployment Cannula as Temporary Left Ventricular Assist Device in a Jehovah's Witness Patient.” J Cardiothorac Vasc Anesth 35, no. 12 (December 2021): 3735–42. https://doi.org/10.1053/j.jvca.2020.12.009.
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    • Boisen, Michael L., Travis Schisler, Lavinia Kolarczyk, Vladyslav Melnyk, Noah Rolleri, Brandi Bottiger, Rebecca Klinger, Emily Teeter, Vidya K. Rao, and Theresa A. Gelzinis. “Corrigendum to 'The Year in Thoracic Anesthesia: Selected Highlights from 2019' [Journal of Cardiothoracic and Vascular Anesthesia 34 (2020) 1733-1744].” J Cardiothorac Vasc Anesth 35, no. 1 (January 2021): 343. https://doi.org/10.1053/j.jvca.2020.06.085.
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    • Boisen, Michael L., Travis Schisler, Lavinia Kolarczyk, Vladyslav Melnyk, Noah Rolleri, Brandi Bottiger, Rebecca Klinger, Emily Teeter, Vidya K. Rao, and Theresa A. Gelzinis. “The Year in Thoracic Anesthesia: Selected Highlights from 2019.” J Cardiothorac Vasc Anesth 34, no. 7 (July 2020): 1733–44. https://doi.org/10.1053/j.jvca.2020.03.016.
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    • Klinger, Rebecca Y., Claire Cunniff, Negmeldeen Mamoun, Mary Cooter, Nazish Hashmi, Thomas Hopkins, Patrick Smith, Matthew Hartwig, and Brandi Bottiger. “Patient-Reported Chronic Pain Outcomes After Lung Transplantation.” Semin Cardiothorac Vasc Anesth 24, no. 1 (March 2020): 96–103. https://doi.org/10.1177/1089253219882432.
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    • Klinger, Rebecca Y., and Joseph P. Mathew. “Intravenous Lidocaine and Postoperative Cognition: Reply.” Anesthesiology 132, no. 2 (February 2020): 398–99. https://doi.org/10.1097/ALN.0000000000003040.
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    • VanDusen, Keith W., Sarada Eleswarpu, Eugene W. Moretti, Michael J. Devinney, Donna M. Crabtree, Daniel T. Laskowitz, Marty G. Woldorff, et al. “The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction.” J Alzheimers Dis 75, no. 4 (2020): 1319–28. https://doi.org/10.3233/JAD-191185.
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    • Klinger, Rebecca Y., and Joseph P. Mathew. “Cerebral Amyloid and Cognition after Surgery: Reply.” Anesthesiology 131, no. 1 (July 2019): 214–15. https://doi.org/10.1097/ALN.0000000000002784.
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    • Klinger, Rebecca Y., Mary Cooter, Tiffany Bisanar, Niccolò Terrando, Miles Berger, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, Joseph P. Mathew, and Joseph P. Neurologic Outcomes Research Group of the Duke Heart Center. “Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.” Anesthesiology 130, no. 6 (June 2019): 958–70. https://doi.org/10.1097/ALN.0000000000002668.
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    • Suarez-Roca, Heberto, Rebecca Y. Klinger, Mihai V. Podgoreanu, Ru-Rong Ji, Martin I. Sigurdsson, Nathan Waldron, Joseph P. Mathew, and William Maixner. “Contribution of Baroreceptor Function to Pain Perception and Perioperative Outcomes.” Anesthesiology 130, no. 4 (April 2019): 634–50. https://doi.org/10.1097/ALN.0000000000002510.
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    • Waldron, Nathan H., Mary Cooter, Jonathan P. Piccini, Kevin J. Anstrom, Rebecca Y. Klinger, Miklos D. Kertai, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, and Joseph P. Mathew. “Predictive ability of perioperative atrial fibrillation risk indices in cardiac surgery patients: a retrospective cohort study.” Can J Anaesth 65, no. 7 (July 2018): 786–96. https://doi.org/10.1007/s12630-018-1119-x.
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    • Allen, T. K., B. M. Mishriky, R. Y. Klinger, and A. S. Habib. “The impact of neuraxial clonidine on postoperative analgesia and perioperative adverse effects in women having elective Caesarean section-a systematic review and meta-analysis.” Br J Anaesth 120, no. 2 (February 2018): 228–40. https://doi.org/10.1016/j.bja.2017.11.085.
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    • Klinger, Rebecca Y., and Ashraf S. Habib. “Acetaminophen and ondansetron: The central serotonergic connection.” J Clin Anesth 40 (August 2017): 101–2. https://doi.org/10.1016/j.jclinane.2017.05.001.
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    • Waldron, Nathan H., Rebecca Y. Klinger, Matthew G. Hartwig, Laurie D. Snyder, James P. Daubert, and Joseph P. Mathew. “Adverse outcomes associated with postoperative atrial arrhythmias after lung transplantation: A meta-analysis and systematic review of the literature.” Clinical Transplantation 31, no. 4 (April 2017). https://doi.org/10.1111/ctr.12926.
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    • Klinger, Rebecca Y., Mary Cooter, Miles Berger, Mihai V. Podgoreanu, Mark Stafford-Smith, Thomas L. Ortel, Ian J. Welsby, et al. “Effect of intravenous lidocaine on the transcerebral inflammatory response during cardiac surgery: a randomized-controlled trial.” Can J Anaesth 63, no. 11 (November 2016): 1223–32. https://doi.org/10.1007/s12630-016-0704-0.
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    • Subramanian, Balachundhar, Charles Nyman, Maria Fritock, Rebecca Y. Klinger, Roman Sniecinski, Philip Roman, Julie Huffmyer, Michelle Parish, Gayane Yenokyan, and Charles W. Hogue. “A Multicenter Pilot Study Assessing Regional Cerebral Oxygen Desaturation Frequency During Cardiopulmonary Bypass and Responsiveness to an Intervention Algorithm.” Anesth Analg 122, no. 6 (June 2016): 1786–93. https://doi.org/10.1213/ANE.0000000000001275.
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    • Klinger, Rebecca Y., Christopher A. Thunberg, William D. White, Manuel Fontes, Nathan H. Waldron, Jonathan P. Piccini, G Chad Hughes, et al. “Intraoperative Magnesium Administration Does Not Reduce Postoperative Atrial Fibrillation After Cardiac Surgery.” Anesth Analg 121, no. 4 (October 2015): 861–67. https://doi.org/10.1213/ANE.0000000000000873.
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    • Klinger, Rebecca Y., Olga G. James, Terence Z. Wong, Mark F. Newman, P Murali Doraiswamy, and Joseph P. Mathew. “Cortical β-amyloid levels and neurocognitive performance after cardiac surgery.” Bmj Open 3, no. 9 (September 20, 2013): e003669. https://doi.org/10.1136/bmjopen-2013-003669.
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    • Klinger, Rebecca Y., William D. White, Betsy Hale, Ashraf S. Habib, and Elliott Bennett-Guerrero. “Hemodynamic impact of dexmedetomidine administration in 15,656 noncardiac surgical cases.” J Clin Anesth 24, no. 3 (May 2012): 212–20. https://doi.org/10.1016/j.jclinane.2011.07.016.
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    • Badie, Nima, James A. Scull, Rebecca Y. Klinger, Ava Krol, and Nenad Bursac. “Conduction block in micropatterned cardiomyocyte cultures replicating the structure of ventricular cross-sections.” Cardiovasc Res 93, no. 2 (February 1, 2012): 263–71. https://doi.org/10.1093/cvr/cvr304.
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    • Pedrotty, Dawn M., Rebecca Y. Klinger, Robert D. Kirkton, and Nenad Bursac. “Cardiac fibroblast paracrine factors alter impulse conduction and ion channel expression of neonatal rat cardiomyocytes.” Cardiovasc Res 83, no. 4 (September 1, 2009): 688–97. https://doi.org/10.1093/cvr/cvp164.
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    • Klinger, Rebecca, and Nenad Bursac. “In Vitro Cellular Implantation Assay To Quantitatively Compare The Ability Of Different Donor Cells To Electrically Conduct Within Cardiac Tissue.” Circulation 118, no. 18 (October 28, 2008): S395–S395.
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    • Pedrotty, Dawn M., Rebecca Y. Klinger, Nima Badie, Sara Hinds, Ara Kardashian, and Nenad Bursac. “Structural coupling of cardiomyocytes and noncardiomyocytes: quantitative comparisons using a novel micropatterned cell pair assay.” Am J Physiol Heart Circ Physiol 295, no. 1 (July 2008): H390–400. https://doi.org/10.1152/ajpheart.91531.2007.
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    • Klinger, Rebecca, and Nenad Bursac. “Cardiac cell therapy in vitro: reproducible assays for comparing the efficacy of different donor cells.” Ieee Eng Med Biol Mag 27, no. 1 (January 2008): 72–80. https://doi.org/10.1109/MEMB.2007.913849.
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    • Pedrotty, Dawn, Rebecca Klinger, and Nenad Bursac. “Paracrine factors from cardiac fibroblasts slow conduction velocity and prolong the action potential duration of cardiomyocytes.” Circulation 116, no. 16 (October 16, 2007): 87–87.
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    • Klinger, R. Y., and L. E. Niklason. “Tissue-Engineered Blood Vessels,” March 31, 2006, 293–322. https://doi.org/10.1002/0471741817.ch12.
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    • Klinger, Rebecca Y., Juliana L. Blum, Bevin Hearn, Benjamin Lebow, and Laura E. Niklason. “Relevance and safety of telomerase for human tissue engineering.” Proc Natl Acad Sci U S A 103, no. 8 (February 21, 2006): 2500–2505. https://doi.org/10.1073/pnas.0508184103.
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    • Poh, Melissa, Matthew Boyer, Amy Solan, Shannon L. M. Dahl, Dawn Pedrotty, Soma S. R. Banik, J Andrew McKee, Rebecca Y. Klinger, Christopher M. Counter, and Laura E. Niklason. “Blood vessels engineered from human cells.” Lancet 365, no. 9477 (June 18, 2005): 2122–24. https://doi.org/10.1016/S0140-6736(05)66735-9.
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    • Yalamuri, Suraj, Rebecca Y. Klinger, W Michael Bullock, Donald D. Glower, Brandi A. Bottiger, and Jeffrey C. Gadsden. “Pectoral Fascial (PECS) I and II Blocks as Rescue Analgesia in a Patient Undergoing Minimally Invasive Cardiac Surgery.” Reg Anesth Pain Med 42, no. 6 (n.d.): 764–66. https://doi.org/10.1097/AAP.0000000000000661.
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  • Conference Papers

    • Klinger, R. Y., M. M. Poh, and L. E. Niklason. “Telomerase gene therapy allows for tissue engineering of blood vessels using autologous cells from elderly patients.” In Circulation, 112:U195–U195. LIPPINCOTT WILLIAMS & WILKINS, 2005.
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