Scholars@Duke
Richard Andrew Krasuski

Richard Andrew Krasuski

Professor of Medicine
Medicine, Cardiology

Selected Publications

Trends in Tetralogy of Fallot-Related Mortality in the United States Between 1999 and 2020.

Journal Article Pediatr Cardiol · March 31, 2025 We sought to identify mortality trends related to Tetralogy of Fallot (ToF) in the U.S. population, with specific emphasis on age-related, racial, and geographic differences. Death certificate data was retrieved from the CDC WONDER database, where crude mo ... Full text Link to item Cite

Permanent Cardiac Pacing in the Fontan Population: A Contemporary Review of Indications, Approaches, and Outcomes.

Journal Article JACC Adv · March 20, 2025 Following the Fontan operation, electrophysiologic abnormalities requiring pacemaker implantation are common, consisting of sinus node dysfunction, complete atrioventricular block, and electromechanical dyssynchrony. Pacemaker implantation in this populati ... Full text Link to item Cite

Characteristics and Survival Outcomes of Hepatocellular Carcinoma After the Fontan Operation.

Journal Article JACC Adv · March 12, 2025 BACKGROUND: The Fontan operation is a surgical procedure to palliate single ventricle congenital heart disease. Hepatocellular carcinoma (HCC) is a rare complication of Fontan-associated liver disease (FALD). OBJECTIVES: The authors aim to examine characte ... Full text Link to item Cite

Outcomes in Patients Receiving Treatment for Pulmonary Arterial Hypertension Associated With Repaired Congenital Heart Disease.

Journal Article JACC Adv · March 2025 BACKGROUND: Pulmonary arterial hypertension (PAH) is a common complication among patients with congenital heart disease (CHD). Despite advances in PAH treatment, evidence for the benefits of PAH therapies in CHD-PAH is limited. OBJECTIVES: This analysis ai ... Full text Link to item Cite

Association of Fontan Pathophysiology With Plasma Bile Acids.

Journal Article JACC Adv · February 2025 BACKGROUND: Patients with Fontan circulation are frail and experience multisystem dysfunction including impaired exercise capacity, low resting and exercise-augmented cardiac output, and progressive liver fibrosis. However, common underlying biochemical ab ... Full text Link to item Cite

The pathophysiology of patent foramen ovale and its related complications.

Journal Article Am Heart J · November 2024 The foramen ovale plays a vital role in sustaining life in-utero; however, a patent foramen ovale (PFO) after birth has been associated with pathologic sequelae in the systemic circulation including stroke/transient ischemic attack (TIA), migraine, high al ... Full text Link to item Cite

Patient-Reported Outcomes Among Adults With Congenital Heart Disease in the Congenital Heart Initiative Registry.

Journal Article JAMA Netw Open · October 1, 2024 IMPORTANCE: In the US, there are more than 1.5 million adults living with congenital heart disease (CHD). The Congenital Heart Initiative (CHI) is a digital, online, patient-empowered registry that was created to advance multicenter research and improve cl ... Full text Link to item Cite

Characteristics and Outcomes of Adults With Congenital Heart Disease in the Cardiac Intensive Care Unit.

Journal Article JACC Adv · August 2024 BACKGROUND: Little is known regarding the characteristics, treatment patterns, and outcomes in patients with adult congenital heart disease (ACHD) admitted to cardiac intensive care units (CICUs). OBJECTIVES: The authors sought to better define the contemp ... Full text Link to item Cite

Prevalence and Predictors of Readmissions in Patients With Hypertrophic Cardiomyopathy and Atrial Fibrillation/Flutter.

Journal Article Am J Cardiol · July 1, 2024 Atrial fibrillation/flutter (AF) is the most common dysrhythmia in patients with hypertrophic cardiomyopathy (HCM). Unexplained left ventricular hypertrophy and left ventricular outflow tract obstruction are integral components of HCM pathology which can c ... Full text Link to item Cite

Multimodality imaging of right ventricular outflow tract disease in adults with congenital heart disease

Chapter · June 20, 2024 As care has advanced for adults with congenital heart disease Congenital heart disease , interest in assessing right ventricular function, particularly for pathologies affecting right sided structures, has grown. Even for patients with no prior interventio ... Full text Cite

Pulmonary Hypertension in Adult Congenital Heart Disease-Related Heart Failure.

Journal Article Heart Fail Clin · April 2024 Already a challenging condition to define, adult congenital heart disease (ACHD) -associated heart failure (HF) often incorporates specific anatomies, including intracardiac and extracardiac shunts, which require rigorous diagnostic characterization and he ... Full text Link to item Cite

Complex Congenital Heart Disease in the Adult.

Journal Article Annual review of medicine · January 2024 Congenital heart disease (CHD), a heterogeneous group of structural abnormalities of the cardiovascular system, is the most frequent cause of severe birth defects. Related to improved pediatric outcomes, there are now more adults living with CHD, including ... Full text Cite

Chronic Thromboembolic Pulmonary Hypertension

Journal Article Current Respiratory Medicine Reviews · January 1, 2024 While the majority of patients have complete resolution of their acute pulmonary embolism (PE) after an adequate course of anticoagulation, some patients remain symptomatic with evidence of chronic PE. Chronic Thromboembolic Pulmonary Hypertension (CTEPH) ... Full text Cite

COVID-19-Related Thrombotic and Bleeding Events in Adults With Congenital Heart Disease.

Journal Article JACC Adv · December 2023 BACKGROUND: Altered coagulation is a striking feature of COVID-19. Adult patients with congenital heart disease (ACHD) are prone to thromboembolic (TE) and bleeding complications. OBJECTIVES: The purpose of this study was to investigate the prevalence and ... Full text Link to item Cite

The Evolution of Pulmonary Artery Denervation for Treatment of Pulmonary Arterial Hypertension.

Journal Article Interv Cardiol Clin · July 2023 Pulmonary arterial hypertension (PAH) is a progressive, life-limiting disease. Despite significant medical progress over the last three decades, the prognosis of PAH remains poor. PAH is associated with sympathetic nervous system over-stimulation and baror ... Full text Link to item Cite

Morbidity and Mortality in Adult Fontan Patients After Heart or Combined Heart-Liver Transplantation.

Journal Article J Am Coll Cardiol · June 6, 2023 BACKGROUND: An increasing number of adult Fontan patients require heart transplantation (HT) or combined heart-liver transplant (CHLT); however, data regarding outcomes and optimal referral time remain limited. OBJECTIVES: The purpose of this study was to ... Full text Link to item Cite

Clinical Outcomes of Adult Fontan-Associated Liver Disease and Combined Heart-Liver Transplantation.

Journal Article J Am Coll Cardiol · June 6, 2023 BACKGROUND: The impact of Fontan-associated liver disease (FALD) on post-transplant mortality and indications for combined heart-liver transplant (CHLT) in adult Fontan patients remains unknown. OBJECTIVES: The purpose of this study was to assess the impac ... Full text Link to item Cite

Comparison of sodium-glucose cotransporter-2 inhibitors and thiazolidinediones for management of non-alcoholic fatty liver disease: A systematic review and meta-analysis.

Journal Article Clin Res Hepatol Gastroenterol · May 2023 BACKGROUND: The pharmacologic treatment of non-alcoholic fatty liver disease (NAFLD) remains unclear. METHODS: Two reviewers searched PubMed, SCOPUS, Cochrane Central and clinicaltrials.gov for randomized controlled trials (RCTs) of patients with NAFLD wit ... Full text Link to item Cite

Periprocedural Complications With Balloon Pulmonary Angioplasty: Analysis of Global Studies.

Journal Article JACC Cardiovasc Interv · April 24, 2023 BACKGROUND: Balloon pulmonary angioplasty (BPA) was introduced as a treatment modality for patients with inoperable, medically refractory chronic thromboembolic pulmonary hypertension decades ago; however, reports of high rates of pulmonary vascular injury ... Full text Link to item Cite

Correlation of Impedance Cardiography-Derived and Cardiac Magnetic Resonance-Derived Stroke Volumes.

Journal Article Current problems in cardiology · February 2023 Cardiac output (CO) and other hemodynamic parameter measurements play an important role in the management of cardiovascular conditions; however, due to limitations of current day technologies, such measurements are either not routinely performed or incorpo ... Full text Cite

FONTAN PATHOPHYSIOLOGY AND PLASMA BILE ACIDS

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · 2023 Cite

CLINICAL CHARACTERISTICS AND OUTCOMES OF HEPATOCELLULAR CARCINOMA FOLLOWING FONTAN PALLIATION

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · 2023 Cite

Where Adults with Congenital Heart Disease Die: Insights from the CDC-WONDER Database.

Journal Article Curr Probl Cardiol · November 2022 The population of adults with congenital heart disease (ACHD) is rapidly increasing. There is limited understanding of location of death and associated disparities in these patients. From 2005-2018, a trend-level analysis was performed using death certific ... Full text Link to item Cite

Disparities in Loss to Follow-Up Among Adults With Congenital Heart Disease in North Carolina.

Journal Article World J Pediatr Congenit Heart Surg · November 2022 BACKGROUND: The AHA/ACC Adult Congenital Heart Disease guidelines recommend that most adults with congenital heart disease (CHD) follow-up with CHD cardiologists every 1 to 2 years because longer gaps in care are associated with adverse outcomes. This stud ... Full text Link to item Cite

Utility of Cardiac Magnetic Resonance Imaging in Predicting Atrial Arrhythmias in Repaired Tetralogy of Fallot.

Journal Article Am J Cardiol · July 1, 2022 Arrhythmias are the leading cause of morbidity and mortality in repaired tetralogy of Fallot (TOF), and over 20% of these patients will develop a sustained atrial arrhythmia during their lifetimes. Cardiac magnetic resonance imaging (cMRI) is frequently pe ... Full text Link to item Cite

Novel oral anticoagulants versus vitamin K antagonists in patients with atrial fibrillation after transcatheter aortic valve replacement: A systematic review and meta-analysis.

Journal Article Catheter Cardiovasc Interv · June 2022 BACKGROUND: The efficacy and safety of novel oral anticoagulants (NOACs) compared to the current guideline-recommended vitamin K antagonists (VKAs) in atrial fibrillation (AF) patients undergoing transcatheter aortic valve replacement (TAVR) has not been w ... Full text Open Access Link to item Cite

Risk Factors and Outcomes Associated With Hypertensive Disorders of Pregnancy in Maternal Congenital Heart Disease.

Journal Article JACC. Advances · June 2022 BackgroundAmong women with congenital heart disease (CHD), risk factors for hypertensive disorders of pregnancy (HDP) and the association of HDP with adverse outcomes are unknown.ObjectivesThe purpose of this study was to identify risk fa ... Full text Cite

Invasive Hemodynamic Evaluation of the Fontan Circulation: Current Day Practice and Limitations.

Journal Article Curr Cardiol Rep · May 2022 PURPOSE OF REVIEW: Establishing the Fontan circulation has led to improved survival in patients born with complex congenital heart diseases. Despite early success, the long-term course of Fontan patients is complicated by multi-organ dysfunction, mainly du ... Full text Link to item Cite

Burden and Impact of Arrhythmias in Repaired Tetralogy of Fallot.

Journal Article Curr Cardiol Rep · March 2022 PURPOSE OF REVIEW: Arrhythmias are a leading cause of morbidity and mortality following repair of tetralogy of Fallot (TOF). This review will highlight current understanding of arrhythmia pathogenesis in this patient population and review novel therapeutic ... Full text Link to item Cite

Pulmonary Hypertension in Adults with Congenital Heart Disease.

Journal Article Cardiol Clin · February 2022 Pulmonary arterial hypertension related to congenital heart disease (PAH-CHD) affects 5% to 10% of adults with CHD and is associated with significant morbidity and mortality. PAH-CHD develops as a consequence of intracardiac or extracardiac systemic-to-pul ... Full text Link to item Cite

Pulmonary Hypertension.

Journal Article Cardiol Clin · February 2022 Full text Link to item Cite

Interventional Management of Chronic Thromboembolic Pulmonary Hypertension.

Journal Article Cardiol Clin · February 2022 Chronic thromboembolic pulmonary hypertension is a distinct form of pulmonary hypertension characterized by the nonresolution of thrombotic material in the pulmonary tree; whenever feasible and safe, first-line treatment should be pulmonary thromboendarter ... Full text Link to item Cite

A multiscale model of vascular function in chronic thromboembolic pulmonary hypertension.

Journal Article Am J Physiol Heart Circ Physiol · August 1, 2021 Chronic thromboembolic pulmonary hypertension (CTEPH) is caused by recurrent or unresolved pulmonary thromboemboli, leading to perfusion defects and increased arterial wave reflections. CTEPH treatment aims to reduce pulmonary arterial pressure and reestab ... Full text Link to item Cite

The Evolving Surgical Burden of Fontan Failure: An Analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database

Conference Annals of Thoracic Surgery · July 1, 2021 Background: Fontan failure often requires surgical therapy in the form of Fontan revision or heart transplantation. We sought to characterize national trends in the surgical burden of Fontan failure and identify risk factors for adverse outcomes. Methods: ... Full text Cite

The Evolving Surgical Burden of Fontan Failure: An Analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database.

Journal Article Ann Thorac Surg · July 2021 BACKGROUND: Fontan failure often requires surgical therapy in the form of Fontan revision or heart transplantation. We sought to characterize national trends in the surgical burden of Fontan failure and identify risk factors for adverse outcomes. METHODS: ... Full text Link to item Cite

IMPACT OF CARDIOVASCULAR COMORBIDITY ON CONGENITAL HEART DISEASE DEATHS

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · 2021 Cite

Algorithmic Approach to Treatment of Aortic Coarctation in Adults

Conference JOURNAL OF VASCULAR SURGERY · 2021 Cite

Aspirin for primary prevention of cardiovascular outcomes in diabetes mellitus: An updated systematic review and meta-analysis.

Journal Article Eur J Prev Cardiol · December 2020 BACKGROUND: The safety and efficacy of aspirin for the primary prevention of cardiovascular disease in patients with diabetes mellitus remains controversial. DESIGN: A meta-analysis to investigate the effects of aspirin for the prevention of cardiovascular ... Full text Link to item Cite

Rate, Causes, and Predictors of 30-Day Readmission Following Hospitalization for Acute Pericarditis.

Journal Article Am J Med · December 2020 BACKGROUND: Acute pericarditis is a frequent cause of hospitalization in the United States. Although recurrence of this condition is common, few studies have investigated hospital readmissions in this patient population. METHODS: We queried the National Re ... Full text Link to item Cite

Contribution of individual components to composite end points in contemporary cardiovascular randomized controlled trials.

Journal Article Am Heart J · December 2020 UNLABELLED: Cardiovascular randomized controlled trials (RCTs) typically set composite end points as the primary outcome to enhance statistical power. However, influence of individual component end points on overall composite outcomes remains understudied. ... Full text Link to item Cite

Approaching End-of-Life Decisions in Adults with Congenital Heart Disease.

Journal Article Curr Cardiol Rep · October 10, 2020 PURPOSE: Despite tremendous advances in medical and surgical care, some adults with congenital heart disease (ACHD) develop terminal conditions where therapy is limited. This paper reviews the important role of palliative care, advance care planning (ACP), ... Full text Link to item Cite

Mustard Baffle Revision With Systemic Ventricular Assist Device Placement.

Journal Article Ann Thorac Surg · October 2020 Systemic right ventricle failure often develops in patients with dextro-transposition of the great arteries who have undergone atrial-level switch procedures. An adult with dextro-transposition of the great arteries with Mustard repair in childhood present ... Full text Link to item Cite

Intensive Care Unit Management of the Adult with Congenital Heart Disease.

Journal Article Curr Cardiol Rep · September 10, 2020 PURPOSE: Adults with congenital heart disease (ACHD) are a rapidly growing population with ever-increasing complexity, and intensive care unit (ICU) management is often necessary. This review summarizes common cardiovascular and non-cardiovascular complica ... Full text Link to item Cite

Deaths in pulmonary hypertension: US location trends.

Journal Article BMJ Support Palliat Care · July 24, 2020 Full text Link to item Cite

Causes of Death and Cardiovascular Comorbidities in Adults With Congenital Heart Disease.

Journal Article J Am Heart Assoc · July 21, 2020 Background Little is known about the contemporary mortality experience among adults with congenital heart disease (CHD). The objectives of this study were to assess the age at death, presence of cardiovascular comorbidities, and most common causes of death ... Full text Link to item Cite

Deaths from heart failure and cancer: location trends.

Journal Article BMJ Support Palliat Care · June 22, 2020 BACKGROUND: Increasing utilisation of hospice services has been a major focus in oncology, while only recently have cardiologists realised the similar needs of dying patients with heart failure (HF). We examined recent trends in locations of deaths in thes ... Full text Link to item Cite

Assessing the quality of reporting of harms in randomized controlled trials published in high impact cardiovascular journals.

Journal Article European heart journal. Quality of care & clinical outcomes · April 2020 Full text Cite

Results of an Expert Consensus Survey on the Treatment of Pulmonary Arterial Hypertension With Oral Prostacyclin Pathway Agents.

Journal Article Chest · April 2020 BACKGROUND: Treatment of pulmonary arterial hypertension (PAH) has evolved substantially over the past two decades and varies according to etiology, functional class (FC), hemodynamic parameters, and other clinical factors. Current guidelines do not provid ... Full text Link to item Cite

Emergency department evaluation of chest pain among adult congenital heart disease patients.

Journal Article Am Heart J · April 2020 BACKGROUND: Data regarding emergency department (ED) assessment of acute chest pain (CP) and incidence of myocardial infarction (MI) among adult congenital heart disease (ACHD) patients, relative to the non-congenital population, is lacking. OBJECTIVES: To ... Full text Link to item Cite

COMPARISON OF YEARLY TRENDS IN LOCATION OF DEATH DUE TO HEART FAILURE VERSUS CANCER

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 24, 2020 Link to item Cite

Pulmonary Valve Endocarditis: The Potential Utility of Multimodal Imaging Prior to Surgery.

Journal Article World journal for pediatric & congenital heart surgery · March 2020 BackgroundThe presence of echocardiographic (echo) evidence is a major criterion for the diagnosis of infective endocarditis (IE) by modified Duke criteria. Pulmonary valve (PV) IE, however, can be challenging to identify by echo. We sought to eva ... Full text Cite

Hybrid transcatheter pulmonary valve replacement with a SAPIEN S3 valve after pulmonary artery banding via left lateral thoracotomy.

Journal Article Catheter Cardiovasc Interv · February 15, 2020 For many patients with repaired congenital heart disease, the need for reintervention on dysfunctional right ventricular outflow tracts is pervasive. Many such patients are poor candidates for both transcatheter pulmonary valve replacement and cardiopulmon ... Full text Link to item Cite

Fragility Index in Cardiovascular Randomized Controlled Trials.

Journal Article Circ Cardiovasc Qual Outcomes · December 2019 BACKGROUND: Efficacy of an intervention is commonly evaluated using P values, in addition to effect size measures such as absolute risk reduction, relative risk reduction, and numbers needed to treat. However, these measures are not always intuitive to cli ... Full text Link to item Cite

Impact of Pulmonary Hypertension on Survival Following Device Closure of Atrial Septal Defects.

Journal Article Am J Cardiol · November 1, 2019 Pulmonary hypertension (PH), defined as mean pulmonary arterial pressure ≥25 mm Hg, may be a complication of a secundum atrial septal defect (ASD). This study sought to evaluate the impact of PH at time of ASD device closure on patient survival. A prospect ... Full text Link to item Cite

Prasugrel vs. Ticagrelor for Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis.

Journal Article Am J Cardiovasc Drugs · October 2019 BACKGROUND: The newer P2Y12 inhibitors have better efficacy than clopidogrel. However, whether ticagrelor or prasugrel have a better comparative safety and efficacy profile, especially in the long-term, remains inconclusive. OBJECTIVE: We compared prasugre ... Full text Link to item Cite

Meta-analysis of use of balloon pulmonary angioplasty in patients with inoperable chronic thromboembolic pulmonary hypertension.

Journal Article Int J Cardiol · September 15, 2019 BACKGROUND: Current guidelines give balloon pulmonary angioplasty (BPA) a Class IIb recommendation for use in inoperable chronic thromboembolic pulmonary hypertension (CTEPH), as its safety and efficacy remain poorly defined. We conducted a systematic revi ... Full text Link to item Cite

Use of Balloon Atrial Septostomy in Patients With Advanced Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis.

Journal Article Chest · July 2019 BACKGROUND: Despite the use and purported benefits of balloon atrial septostomy (BAS), its safety, efficacy, and therapeutic role in the setting of advanced pulmonary arterial hypertension (PAH) are not well defined. OBJECTIVE: The goal of this study was t ... Full text Link to item Cite

Level and Prevalence of Spin in Published Cardiovascular Randomized Clinical Trial Reports With Statistically Nonsignificant Primary Outcomes: A Systematic Review.

Journal Article JAMA Netw Open · May 3, 2019 IMPORTANCE: Clinical researchers are obligated to present results objectively and accurately to ensure readers are not misled. In studies in which primary end points are not statistically significant, placing a spin, defined as the manipulation of language ... Full text Link to item Cite

Assessing the Quality of Abstracts in Randomized Controlled Trials Published in High Impact Cardiovascular Journals.

Journal Article Circ Cardiovasc Qual Outcomes · May 2019 BACKGROUND: In the busy world of cardiovascular medicine, abstracts may be the only part of a publication that clinicians read. Therefore, it is critical for abstracts to accurately reflect article content. The extended CONSORT (Consolidated Standards of R ... Full text Link to item Cite

Outcomes of lung disease-associated pulmonary hypertension and impact of elevated pulmonary vascular resistance.

Journal Article Respir Med · April 2019 BACKGROUND: The clinical characteristics, hemodynamic changes and outcomes of lung disease-associated pulmonary hypertension (LD-PH) are poorly defined. METHODS: A prospective cohort of PH patients undergoing initial hemodynamic assessment was collected, f ... Full text Link to item Cite

ADULTS AND ADOLESCENTS WITH CONGENITAL HEART DISEASE: WHO ARE WE LOSING TO FOLLOW UP?

Conference Journal of the American College of Cardiology · March 2019 Full text Cite

Association Between Obesity and Cardiovascular Outcomes: A Systematic Review and Meta-analysis of Mendelian Randomization Studies.

Journal Article JAMA network open · November 2018 ImportanceAlthough dyslipidemia has been consistently shown to be associated with atherogenesis, an association between obesity and cardiovascular disease outcomes remains controversial. Mendelian randomization can minimize confounding if variable ... Full text Open Access Cite

Is Anticoagulation Beneficial in Pulmonary Arterial Hypertension?

Journal Article Circ Cardiovasc Qual Outcomes · September 2018 Background Data about anticoagulation in pulmonary arterial hypertension (PAH) patients are inconsistent. The objective of this study was to examine the impact of adjunctive oral anticoagulants in patients with PAH through meta-analysis, and to further ass ... Full text Open Access Link to item Cite

Heart Transplantation and Mechanical Circulatory Support in Adults with Congenital Heart Disease.

Journal Article Curr Cardiol Rep · August 9, 2018 PURPOSE OF REVIEW: To assess current management strategies for advanced heart failure in adults with congenital heart disease, including heart transplantation and mechanical circulatory support. RECENT FINDINGS: Current data demonstrate that adults with CH ... Full text Open Access Link to item Cite

Effect of Patent Foramen Ovale in Patients With Pulmonary Hypertension.

Journal Article Am J Cardiol · August 1, 2018 Septostomy reduces right ventricular (RV) workload at the expense of hypoxemia in patients with advanced pulmonary hypertension (PH). A patent foramen ovale (PFO) may serve as a "natural" septostomy, but the incidence and impact of a PFO in PH remains unce ... Full text Open Access Link to item Cite

Transcatheter closure of patent foramen ovale following cryptogenic stroke: An updated meta-analysis of randomized controlled trials.

Journal Article Am Heart J · May 2018 BACKGROUND: Transcatheter closure of patent foramen ovale (PFO) after cryptogenic stroke has long been a contentious issue. Herein, we pool aggregate data examining safety and efficacy of transcatheter closure of PFO compared with medical therapy following ... Full text Open Access Link to item Cite

A Bayesian network meta-analysis of PCSK9 inhibitors, statins and ezetimibe with or without statins for cardiovascular outcomes.

Journal Article Eur J Prev Cardiol · May 2018 Background The comparative effects of statins, ezetimibe with or without statins and proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors remain unassessed. Design Bayesian network meta-analysis was conducted to compare treatment groups. Method ... Full text Open Access Link to item Cite

Branch Pulmonary Artery Valve Implantation Reduces Pulmonary Regurgitation and Improves Right Ventricular Size/Function in Patients With Large Right Ventricular Outflow Tracts.

Journal Article JACC Cardiovasc Interv · March 26, 2018 OBJECTIVES: The authors sought to assess the intermediate-term effects of percutaneous placed valves in the branch pulmonary artery (PA) position. BACKGROUND: Most patients with large right ventricular outflow tracts (RVOTs) are excluded from available per ... Full text Open Access Link to item Cite

OUTCOME OF LUNG DISEASE-RELATED PULMONARY HYPERTENSION AND IMPACT OF VASOREACTIVITY

Conference Journal of the American College of Cardiology · March 2018 Full text Cite

Coronary Disease and Modifying Cardiovascular Risk in Adult Congenital Heart Disease Patients: Should General Guidelines Apply?

Journal Article Prog Cardiovasc Dis · 2018 There are >1.4 million adult congenital heart disease (CHD; ACHD) patients living in the United States. Coronary artery disease (CAD) is at least as prevalent in ACHD patients as in the general population and has become a leading cause of their mortality. ... Full text Open Access Link to item Cite

A Multifaceted Approach to Pulmonary Hypertension in Adults With Congenital Heart Disease.

Journal Article Prog Cardiovasc Dis · 2018 Advances in the management of congenital heart disease (CHD) in children have resulted in growing numbers of adults with CHD. Pulmonary arterial hypertension related to CHD (PAH-CHD) is a common complication, affecting up to 10% of patients; and can arise ... Full text Open Access Link to item Cite

Transcatheter Valve Replacement for Right-sided Valve Disease in Congenital Heart Patients.

Journal Article Prog Cardiovasc Dis · 2018 Pulmonary and/or tricuspid valve dysfunction is common among individuals with congenital heart disease, and surgical intervention often carries prohibitive risks. Transcatheter valve replacement (TVR) of the right-sided cardiac valves has become a viable t ... Full text Open Access Link to item Cite

Long Term Consequences of the Fontan Procedure and How to Manage Them.

Journal Article Prog Cardiovasc Dis · 2018 In 1971, Fontan and Baudet described a surgical technique for successful palliation of patients with tricuspid atresia. Subsequently, this technique has been applied to treat most forms of functional single ventricles and has become the current standard of ... Full text Open Access Link to item Cite

Evaluation of Industrial Compensation to Cardiologists in 2015.

Journal Article Am J Cardiol · December 15, 2017 The categorization and characterization of pharmaceutical and device manufacturers or group purchasing organization payments to clinicians is an important step toward assessing conflicts of interest and the potential impact of these payments on practice pa ... Full text Open Access Link to item Cite

Pulmonic Valve Disease: Review of Pathology and Current Treatment Options.

Journal Article Curr Cardiol Rep · September 16, 2017 PURPOSE OF REVIEW: Our review is intended to provide readers with an overview of disease processes involving the pulmonic valve, highlighting recent outcome studies and guideline-based recommendations; with focus on the two most common interventions for tr ... Full text Open Access Link to item Cite

Meta-analysis of Placebo-Controlled Randomized Controlled Trials on the Prevalence of Statin Intolerance.

Journal Article Am J Cardiol · September 1, 2017 The prevalence of intolerance varies widely. Stopping statin therapy is associated with worse outcomes in patients with cardiovascular disease. Despite extensive studies, the benefits and risks of statins continue to be debated by clinicians and the lay pu ... Full text Open Access Link to item Cite

Health insurance and racial disparities in pulmonary hypertension outcomes.

Journal Article Am J Manag Care · August 2017 OBJECTIVES: Pulmonary hypertension portends a poorer prognosis for blacks versus white populations, but the underlying reasons are poorly understood. We investigated associations of disease characteristics, insurance status, and race with clinical outcomes ... Open Access Link to item Cite

Deep thoughts on lipids and cognition.

Journal Article Curr Opin Lipidol · June 2017 Full text Open Access Link to item Cite

Pacemaker and Defibrillator Implantation in Patients with Transposition of the Great Arteries.

Journal Article J Innov Card Rhythm Manag · April 2017 Transposition of the great arteries (TGA) is represented in 5% to 7% of patients with congenital heart disease. These patients face a significant burden of arrhythmia and sudden cardiac death throughout their lives, and many eventually undergo pacemaker or ... Full text Link to item Cite

Characteristics of pediatric pulmonary hypertension trials registered on ClinicalTrials.gov.

Journal Article Pulm Circ · 2017 The investigation of pediatric pulmonary hypertension (PH) drugs has been identified as a high priority by the United States National Institutes of Health (NIH). Studying pediatric PH is challenging due to the rare and heterogeneous nature of the disease. ... Full text Open Access Link to item Cite

Extra-cardiac manifestations of adult congenital heart disease.

Journal Article Trends Cardiovasc Med · October 2016 Advancement in correction or palliation of congenital cardiac lesions has greatly improved the lifespan of congenital heart disease patients, resulting in a rapidly growing adult congenital heart disease (ACHD) population. As this group has increased in nu ... Full text Open Access Link to item Cite

Contributors to and impact of residual shunting after device closure of atrial septal defects.

Journal Article Am Heart J · July 2016 BACKGROUND: The prevalence of residual shunt in patients after device closure of atrial septal defect and its impact on long-term outcome has not been previously defined. METHODS: From a prospective, single-institution registry of 408 patients, we selected ... Full text Open Access Link to item Cite

Should Physicians be Encouraged to use Generic Names and to Prescribe Generic Drugs?

Journal Article Am J Cardiol · June 1, 2016 While using the brand names seems like a trivial issue at the outset, using these names is inherently problematic. Cardiovascular drugs remain the most commonly prescribed drugs by the physicians. The junior doctors are likely to introject practices of the ... Full text Open Access Link to item Cite

Safety and Use of Anticoagulation After Aortic Valve Replacement With Bioprostheses: A Meta-Analysis.

Journal Article Circ Cardiovasc Qual Outcomes · May 2016 BACKGROUND: The American College of Cardiology guidelines recommend 3 months of anticoagulation after replacement of the aortic valve with a bioprosthesis. However, there remains great variability in the current clinical practice and conflicting results fr ... Full text Open Access Link to item Cite

IMPACT OF DEVICE TYPE ON RESIDUAL SHUNT FOLLOWING PERCUTANEOUS ATRIAL SEPTAL DEFECT CLOSURE

Conference Journal of the American College of Cardiology · April 2016 Full text Cite

Conflicts of Interest and Outcomes of Cardiovascular Trials.

Journal Article Am J Cardiol · March 1, 2016 Conflicts of interests have long been recognized as potential sources of influence in the conduct and reporting of clinical trials. This controversy was again rekindled after the publication of the latest statin guidelines and a series of studies regarding ... Full text Open Access Link to item Cite

Two Cases of Late Shone Syndrome With Pulmonary Hypertension: Heart-Lung Transplant or Valve Surgery?

Journal Article World J Pediatr Congenit Heart Surg · January 2016 Two cases of Shone syndrome with severe mitral and aortic valve problems and pulmonary hypertension were referred for heart-lung transplantation. Severely elevated pulmonary vascular resistance (PVR) was confirmed as was severe periprosthetic mitral and ao ... Full text Open Access Link to item Cite

Impact of Funding Source on Clinical Trial Results Including Cardiovascular Outcome Trials.

Journal Article Am J Cardiol · December 15, 2015 Previous authors have suggested a higher likelihood for industry-sponsored (IS) studies to have positive outcomes than non-IS studies, though the influence of publication bias was believed to be a likely confounder. We attempted to control for the latter u ... Full text Open Access Link to item Cite

Isolated Noncompaction of the Left Ventricle in Adults.

Journal Article J Am Coll Cardiol · August 4, 2015 Isolated left ventricular noncompaction (ILVNC) is a cardiomyopathy that was first described in 1926 as a "spongy myocardium." The disorder results from intrauterine arrest of compaction of the loose interwoven meshwork of the fetal myocardial primordium a ... Full text Open Access Link to item Cite

Incremenal Value of Cardiac Magnetic Resonance for Assessing Pulmonic Valve Regurgitation.

Journal Article J Heart Valve Dis · July 2015 BACKGROUND AND AIM OF THE STUDY: Cardiac magnetic resonance (CMR) is the 'gold standard' for quantifying pulmonic regurgitation (PR) in adults with congenital heart disease, but remains costly and is less readily available than echocardiography. Qualitativ ... Open Access Link to item Cite

Incremenal Value of Cardiac Magnetic Resonance for Assessing Pulmonic Valve Regurgitation

Journal Article The Journal of heart valve disease · July 1, 2015 BACKGROUND AND AIM OF THE STUDY: Cardiac magnetic resonance (CMR) is the 'gold standard' for quantifying pulmonic regurgitation (PR) in adults with congenital heart disease, but remains costly and is less readily available than echocardiography. Qualitativ ... Open Access Cite

Impact of diabetes in patients with pulmonary hypertension.

Journal Article Pulm Circ · March 2015 Diabetes complicates management in a number of disease states and adversely impacts survival; how diabetes affects patients with pulmonary hypertension (PH) has not been well characterized. With insulin resistance having recently been demonstrated in PH, w ... Full text Open Access Link to item Cite

IMPACT OF PERSISTENT RIGHT TO LEFT SHUNT IN DEVICE-OCCLUDED ATRIAL SEPTAL DEFECTS

Conference Journal of the American College of Cardiology · March 2015 Full text Cite

Therapy and clinical trials.

Journal Article Curr Opin Lipidol · February 2015 Full text Open Access Link to item Cite

Therapy and clinical trials.

Journal Article Curr Opin Lipidol · October 2014 Full text Open Access Link to item Cite

Impact of insurance status on survival in pulmonary hypertension

Conference EUROPEAN HEART JOURNAL · September 1, 2014 Link to item Cite

Comparison of long-term postoperative sequelae in patients with tetralogy of Fallot versus isolated pulmonic stenosis.

Journal Article Am J Cardiol · July 15, 2014 Patients with tetralogy of Fallot (TOF) after complete repair and pulmonic stenosis (PS) after surgical valvotomy often develop significant pulmonic regurgitation (PR) that eventually requires valve replacement. Although criteria exist for the timing of pu ... Full text Open Access Link to item Cite

Pharmacologic management of perioperative pulmonary hypertension.

Journal Article J Cardiovasc Pharmacol · April 2014 Perioperative pulmonary hypertension can originate from an established disease or acutely develop within the surgical setting. Patients with increased pulmonary vascular resistance are consequently at greater risk for complications. Despite the various spe ... Full text Open Access Link to item Cite

A CASE OF REVERSIBLE “EISENMENGER SYNDROME”

Conference Journal of the American College of Cardiology · April 2014 Full text Cite

Adult congenital heart disease

Chapter · February 20, 2014 Cite

Inhaled treprostinil sodium for pulmonary hypertension

Journal Article Expert Opinion on Orphan Drugs · January 1, 2014 Introduction: Pulmonary arterial hypertension is an increasingly recognized heterogeneous disease with significant morbidity and mortality, requiring a multimodal approach to treatment. Inhalation administration of treprostinil sodium (Tyvaso®) permits hig ... Full text Open Access Cite

Endovascular treatment of congenital pulmonary artery lesions

Chapter · January 1, 2014 Pulmonary artery anomalies such as peripheral pulmonic stenosis or arteriovenous malformations are congenital heart lesions that can result in considerable symptoms and right heart failure. Pulmonary artery interventions can be highly demanding and benefit ... Full text Cite

Tricuspid regurgitation and right ventricular function after mitral valve surgery with or without concomitant tricuspid valve procedure.

Journal Article J Thorac Cardiovasc Surg · November 2013 OBJECTIVES: To study the effect of mitral valve repair with or without concomitant tricuspid valve repair on functional tricuspid regurgitation and right ventricular function. METHODS: From 2001 to 2007, 1833 patients with degenerative mitral valve disease ... Full text Open Access Link to item Cite

PINOT NOIR: pulmonic insufficiency improvement with nitric oxide inhalational response.

Journal Article J Cardiovasc Magn Reson · September 4, 2013 BACKGROUND: Tetralogy of Fallot (TOF) repair and pulmonary valvotomy for pulmonary stenosis (PS) lead to progressive pulmonary insufficiency (PI), right ventricular enlargement and dysfunction. This study assessed whether pulmonary regurgitant fraction mea ... Full text Open Access Link to item Cite

Closing the gaps in treatment and management strategies in PAH

Journal Article Journal of Managed Care Medicine · July 26, 2013 Pulmonary arterial hypertension (PAH ) is not typically diagnosed in a timely manner. It is now known that this condition affects all ages and genders and thus should be considered in patients with dyspnea, angina, fatigue, and syncope, particularly if the ... Cite

Migraine headaches following mitral valvuloplasty: Koch's postulates finally satisfied?

Journal Article J Invasive Cardiol · June 2013 The relationship between patent foramen ovale and migraine headache is a topic surrounded by much controversy. We present the case of a 45-year-old woman who underwent successful percutaneous mitral balloon valvuloplasty for rheumatic mitral valve stenosis ... Open Access Link to item Cite

Therapy and clinical trials.

Journal Article Curr Opin Lipidol · June 2013 Full text Open Access Link to item Cite

OUTCOME OF LUNG DISEASE-RELATED PULMONARY HYPERTENSION AND IMPACT OF PULMONARY VASOREACTIVITY

Conference Journal of the American College of Cardiology · March 2013 Full text Cite

CARDIAC STRUCTURE AND FUNCTION DIFFER BY ETIOLOGY IN LONGSTANDING PULMONIC REGURGITATION

Conference Journal of the American College of Cardiology · March 2013 Full text Cite

Embolization of patent foramen ovale closure devices: incidence, role of imaging in identification, potential causes, and management.

Journal Article Tex Heart Inst J · 2013 Transcatheter patent foramen ovale (PFO) closure is an alternative to antiplatelet or anticoagulative therapy in patients with cryptogenic stroke, and it is associated with a small incidence of periprocedural sequelae. Because embolization of PFO closure d ... Open Access Link to item Cite

Off-label closure during CLOSURE study.

Journal Article J Invasive Cardiol · November 2012 BACKGROUND: The role of percutaneous closure of patent foramen ovale (PFO) in patients with cryptogenic stroke or transient ischemic attack remains controversial. Registry data have suggested considerable benefit of closure over medical therapy, but the pr ... Open Access Link to item Cite

Percutaneous pulmonary valve technology

Chapter · October 1, 2012 Pulmonic valve disease is ubiquitous across age, gender and ethnicity. The pulmonary valve is unique in that the incidence of congenital cases far outnumbers the incidence of acquired cases. The most prevalent pulmonary valve disease is pulmonary stenosis ... Cite

Effect of obesity on B-type natriuretic peptide levels in patients with pulmonary arterial hypertension.

Journal Article Am J Cardiol · September 15, 2012 Brain natriuretic peptide (BNP) levels are lower in obese patients with left ventricular failure than in their comparably ill, leaner counterparts. The effect of obesity on BNP in patients with pulmonary arterial hypertension (PAH) is unknown. We reviewed ... Full text Open Access Link to item Cite

Percutaneous pulmonary valve implantation in left pulmonary artery branch in a patient with a functional single lung.

Journal Article J Invasive Cardiol · September 2012 Percutaneous pulmonary valve technology has had a great impact on patients with congenital and acquired heart disease. In some patients, implantation of a percutaneous pulmonary valve may not be possible due to the morphology of the existing right ventricu ... Link to item Cite

Partial anomalous pulmonary venous connection and pulmonary arterial hypertension.

Journal Article Respirology · August 2012 BACKGROUND AND OBJECTIVE: Isolated partial anomalous pulmonary venous connection (PAPVC) has been implicated as a cause of pulmonary arterial hypertension (PAH); however this condition is often overlooked in the diagnostic work up of patients with PH. We s ... Full text Open Access Link to item Cite

Congenital heart disease and pulmonary hypertension.

Journal Article Heart Fail Clin · July 2012 Many patients with congenital heart disease and systemic-to-pulmonary shunts develop pulmonary arterial hypertension (PAH), particularly if the cardiac defect is left unrepaired. A persistent increase in pulmonary blood flow may lead to obstructive arterio ... Full text Open Access Link to item Cite

Provoked exercise desaturation in patent foramen ovale and impact of percutaneous closure.

Journal Article JACC Cardiovasc Interv · April 2012 OBJECTIVES: This study was designed to assess the prevalence of provoked exercise desaturation (PED) in patients with patent foramen ovale (PFO) referred for cardiovascular evaluation and to evaluate the impact of PFO closure. BACKGROUND: Platypnea orthode ... Full text Open Access Link to item Cite

DOES PATIENT SELECTION MAKE THE CLOSURE STUDY LESS APPLICABLE?

Conference Journal of the American College of Cardiology · March 2012 Full text Cite

PREDICTORS OF PULMONARY ARTERIAL HYPERTENSION IN ATRIAL SEPTAL DEFECT PATIENTS

Journal Article Journal of the American College of Cardiology · March 2012 Full text Cite

Pulmonary vein isolation for the treatment of drug-refractory atrial fibrillation in adults with congenital heart disease.

Journal Article Congenit Heart Dis · 2012 BACKGROUND: Atrial fibrillation (AF) is a common arrhythmia in adults with congenital heart disease (CHD). Long-term antiarrhythmic therapy (AAT) in these patients has significant shortcomings. The safety and efficacy of pulmonary vein antrum isolation (PV ... Full text Open Access Link to item Cite

PINOT NOIR: Pulmonic INsufficiency imprOvemenT with Nitric Oxide Inhalational Response.

Journal Article Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · January 2012 Full text Open Access Cite

Therapy and clinical trials.

Journal Article Curr Opin Lipidol · December 2011 Full text Open Access Link to item Cite

Downstream coronary effects of drug-eluting stents.

Journal Article Am Heart J · October 2011 BACKGROUND: Antiproliferative agents used in drug-eluting stents (DES) attenuate atherosclerosis, yet DES implantation has been linked to endothelial dysfunction. The downstream effects of DES on new lesion formation have not been previously directly exami ... Full text Open Access Link to item Cite

Modified INOvent for delivery of inhaled nitric oxide during cardiac MRI.

Journal Article Magn Reson Imaging · October 2011 BACKGROUND: The aim of this study was to assess the feasibility of delivering NO through a modified system to allow clearance of the magnetic field and thus compatibility with cardiac magnetic resonance (CMR). Nitric oxide (NO) is an inhalational, selectiv ... Full text Open Access Link to item Cite

Association of anemia and long-term survival in patients with pulmonary hypertension.

Journal Article Int J Cardiol · August 4, 2011 BACKGROUND: Anemia is a marker of worsened clinical outcome in patients with heart failure from left ventricular dysfunction. Pulmonary hypertension often results in right ventricular dysfunction. Accordingly we sought to examine the association of hemoglo ... Full text Open Access Link to item Cite

The effect of gemfibrozil, niacin and cholestyramine combination therapy on metabolic syndrome in the Armed Forces Regression Study.

Journal Article Am J Med Sci · May 2011 INTRODUCTION: Metabolic syndrome is a powerful predictor of cardiovascular events independent of overt diabetes. Dietary restriction and weight loss modify metabolic syndrome components. This study addresses whether combination pharmacologic therapy focuse ... Full text Open Access Link to item Cite

Response to inhaled nitric oxide predicts survival in patients with pulmonary hypertension.

Journal Article J Card Fail · April 2011 OBJECTIVE: To examine the ability of vasodilator response to predict survival in a diverse cohort of patients with pulmonary hypertension (PH). PATIENTS & METHODS: A total of 214 consecutive treatment-naive patients referred for invasive PH evaluation were ... Full text Open Access Link to item Cite

Long-term outcome and impact of surgery on adults with coronary arteries originating from the opposite coronary cusp.

Journal Article Circulation · January 18, 2011 BACKGROUND: An anomalous coronary artery from the opposite sinus of Valsalva may increase sudden death risk in children and young adults, and surgical intervention is often recommended. The impact of this lesion when recognized in the adult and its managem ... Full text Open Access Link to item Cite

Impact of increases in high-density lipoprotein cholesterol on cardiovascular outcomes during the armed forces regression study.

Journal Article J Cardiovasc Pharmacol Ther · December 2010 INTRODUCTION: high-density lipoprotein (HDL) cholesterol is a well-established inverse risk factor for cardiovascular disease. The extent to which cardiovascular risk can be modified through changes in HDL, however, is less clear. We further examined the r ... Full text Open Access Link to item Cite

When 'blue babies' grow up: What you need to know about tetralogy of Fallot.

Journal Article Cleve Clin J Med · November 2010 Most babies born with tetralogy of Fallot undergo corrective surgery and survive to adulthood. However, as they get older they are prone to a number of long-term problems, and they often do not receive expert-level follow-up care. This review of the adult ... Full text Open Access Link to item Cite

Pulmonary hypertension and elevated transpulmonary gradient in patients with mitral stenosis.

Journal Article J Heart Valve Dis · November 2010 BACKGROUND AND AIM OF THE STUDY: Pulmonary hypertension frequently complicates mitral stenosis, with a subset of these patients exhibiting pressures well in excess of their mitral valve hemodynamics. The prevalence of this condition and its impact on clini ... Open Access Link to item Cite

Therapy and clinical trials.

Journal Article Curr Opin Lipidol · October 2010 Full text Open Access Link to item Cite

Reply

Journal Article American Journal of Cardiology · August 15, 2010 Full text Open Access Cite

Impact of fibrinogen levels on angiographic progression and 12-year survival in the armed forces regression study.

Journal Article Angiology · May 2010 We assessed the role of fibrinogen levels on angiographic progression and long-term survival among 111 patients with coronary disease enrolled in the Armed Forces Regression Study (AFREGS). Baseline fibrinogen levels and quantitative coronary angiography w ... Full text Open Access Link to item Cite

Effect of motorized scooters on quality of life and cardiovascular risk.

Journal Article Am J Cardiol · March 1, 2010 Physical inactivity increases cardiovascular risk. The possible adverse effects of regular motorized scooter use, recently popularized for patients with physical limitations, has not been previously examined. We performed a single-center, retrospective coh ... Full text Link to item Cite

VASODILATOR RESPONSE PREDICTS LONG-TERM SURVIVAL IN PULMONARY HYPERTENSION REGARDLESS OF ETIOLOGY

Journal Article Journal of the American College of Cardiology · March 2010 Full text Cite

DOWNSTREAM CORONARY EFFECTS OF DRUG ELUTING STENTS: UNINTENDED THERAPEUTIC TARGET?

Journal Article Journal of the American College of Cardiology · March 2010 Full text Cite

Effects of combination lipid therapy on coronary stenosis progression and clinical cardiovascular events in coronary disease patients with metabolic syndrome: a combined analysis of the Familial Atherosclerosis Treatment Study (FATS), the HDL-Atherosclerosis Treatment Study (HATS), and the Armed Forces Regression Study (AFREGS).

Journal Article Am J Cardiol · December 1, 2009 We examined the impact of metabolic syndrome (MS) on coronary stenosis progression and major cardiovascular (CV) events and investigated the mitigating effects of low-density lipoprotein (LDL) cholesterol lowering and LDL cholesterol lowering plus high-den ... Full text Link to item Cite

Aneurysmal ascending to descending aorta bypass graft compressing the pulmonary artery.

Journal Article Interact Cardiovasc Thorac Surg · October 2009 We describe the first case of aneurysmal degeneration of ascending to descending aortic bypass graft with compression of main pulmonary artery in a young patient who had prior history of interrupted aortic arch. We also outline the value of multimodality i ... Full text Link to item Cite

Persistent tricuspid regurgitation and its predictor in adults after percutaneous and isolated surgical closure of secundum atrial septal defect.

Journal Article Am J Cardiol · September 15, 2009 The fate of functional tricuspid regurgitation (TR) after closure of a secundum atrial septal defect (ASD) without any corrective tricuspid valve (TV) surgery remains unclear. We investigated this and the predictors of persistent TR after ASD closure. Thir ... Full text Link to item Cite

Impact of anemia in patients with pulmonary hypertension

Journal Article EUROPEAN HEART JOURNAL · September 1, 2009 Open Access Link to item Cite

Racial disparities in survival in patients with pulmonary hypertension

Journal Article EUROPEAN HEART JOURNAL · September 1, 2009 Link to item Cite

Prevalence and repair of intraoperatively diagnosed patent foramen ovale and association with perioperative outcomes and long-term survival.

Journal Article JAMA · July 15, 2009 CONTEXT: A recent survey suggested that cardiothoracic surgeons may alter planned procedures to repair incidentally discovered patent foramen ovale (PFO). How frequently this occurs and the impact on outcomes remain unknown. OBJECTIVE: To measure the frequ ... Full text Open Access Link to item Cite

Therapy and clinical trials.

Journal Article Curr Opin Lipidol · June 2009 Full text Link to item Cite

APPARATUS AND METHOD FOR TREATING CARDIOVASCULAR DISEASES

Journal Article · January 22, 2009 A method is provided for treating a cardiovascular disease, such as pulmonary arterial hypertension, an arrhythmia, or heart failure. One step of the method includes providing an apparatus. The apparatus includes an expandable support member having opposit ... Cite

Morphology of the patent foramen ovale in asymptomatic versus symptomatic (stroke or transient ischemic attack) patients.

Journal Article Am J Cardiol · January 1, 2009 The clinical implications of patent foramen ovale (PFO) morphology are still debated. Quantitative analysis by transesophageal echocardiography (TEE) is helpful in characterizing PFO morphology. The aim of this study was to determine whether there were dif ... Full text Link to item Cite

Therapy and clinical trials.

Journal Article Curr Opin Lipidol · October 2008 Full text Link to item Cite

Perioperative bridging therapy with unfractionated heparin or low-molecular-weight heparin in patients with mechanical prosthetic heart valves on long-term oral anticoagulants (from the REGIMEN Registry).

Journal Article Am J Cardiol · October 1, 2008 Patients with mechanical prosthetic heart valves require long-term oral anticoagulant therapy (OAT). During the temporary interruption of OAT, bridging anticoagulant therapy with unfractionated heparin (UFH) or low-molecular-weight heparin (LMWH) is recomm ... Full text Link to item Cite

An elderly woman with shortness of breath.

Journal Article Cleve Clin J Med · May 2008 Full text Link to item Cite

Therapy and clinical trials.

Journal Article Curr Opin Lipidol · April 2008 Full text Link to item Cite

Tissue harmonic imaging in echocardiography: better valve imaging, but at what cost?

Journal Article Echocardiography · February 2008 BACKGROUND: Tissue harmonic imaging (THI) improves echocardiographic image quality and is widely utilized. Unfortunately it also makes structures appear artificially thickened. We sought to examine its impact on the imaging of left-sided heart valves. METH ... Full text Link to item Cite

Short-term clinical effects of tolvaptan, an oral vasopressin antagonist, in patients hospitalized for heart failure: the EVEREST Clinical Status Trials.

Journal Article JAMA · March 28, 2007 CONTEXT: Heart failure causes more than 1 million US hospitalizations yearly, mostly related to congestion. Tolvaptan, an oral, nonpeptide, selective vasopressin V2-receptor antagonist, shows promise in this condition. OBJECTIVE: To evaluate short-term eff ... Full text Link to item Cite

When and how to fix a 'hole in the heart': approach to ASD and PFO.

Journal Article Cleve Clin J Med · February 2007 Abnormalities in the atrial septum range in severity from patent foramen ovale (PFO), a residual cardiac structure found in approximately 25% of the general population, to uncommon, complex lesions associated with significant shunt flow and heart enlargeme ... Full text Link to item Cite

Coarctation of the Aorta

Chapter · January 1, 2007 Full text Cite

Patent ductus arteriosus closure

Journal Article Journal of Interventional Cardiology · October 1, 2006 Patent ductus arteriosus is a common clinical lesion which increases the risk of endocarditis and may lead to heart failure and pulmonary hypertension. Devices and techniques have advanced to the point that in most patients percutaneous closure should be t ... Full text Cite

Educational attainment has a limited impact on disease management outcomes in heart failure.

Journal Article Dis Manag · June 2006 The objective of this study was to assess whether educational attainment moderates outcomes in the intervention group in a trial of disease management in heart failure (HF). Data were collected from a sample of 654 patients enrolled in the disease manageme ... Full text Link to item Cite

Clinical outcomes with unfractionated heparin or low-molecular-weight heparin as bridging therapy in patients on long-term oral anticoagulants: the REGIMEN registry.

Journal Article J Thromb Haemost · June 2006 BACKGROUND: Patients who receive long-term oral anticoagulant (OAC) therapy often require interruption of OAC for an elective surgical or an invasive procedure. Heparin bridging therapy has been used in these situations, although the optimal method has not ... Full text Link to item Cite

Peripheral blood levels of matrix metalloproteinases in patients referred for percutaneous balloon mitral valve commissurotomy.

Journal Article J Heart Valve Dis · May 2006 BACKGROUND AND AIM OF THE STUDY: Inflammation may play a central role in the progression of stenotic valvular heart disease. Serum levels of matrix metalloproteinases (MMPs), markers of extracellular matrix (ECM) turnover and potential markers of active in ... Link to item Cite

The cardiovascular patient's perceptions of complementary and alternative medicine.

Journal Article Clin Cardiol · April 2006 BACKGROUND: Complementary and alternative medicine (CAM) use is common among patients with cardiovascular disorders and is generally underrecognized by physicians. The attitudes of these patients regarding these therapies and their perceptions of safety an ... Full text Link to item Cite

Late "adult form" scimitar syndrome presenting with "infant form" complications.

Journal Article J Invasive Cardiol · February 2006 This case report describes an 85-year-old woman with complications resulting from scimitar syndrome, anomalous drainage of the right pulmonary veins into the inferior vena cava. In addition to being the oldest reported case of this congenital anomaly, this ... Link to item Cite

Vasodilators in aortic regurgitation.

Journal Article N Engl J Med · January 19, 2006 Link to item Cite

Vasodilators in aortic regurgitation

Journal Article NEW ENGLAND JOURNAL OF MEDICINE · January 19, 2006 Link to item Cite

Impedance cardiography as a predictor of clinical outcome in heart failure patients

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · 2006 Cite

HDL-raising strategies in the treatment of coronary artery disease: perspectives from the Armed Forces Regression Study.

Journal Article Curr Opin Lipidol · December 2005 PURPOSE OF REVIEW: Even with the aggressive reduction of LDL-cholesterol, the risk of cardiovascular events in patients with coronary artery disease remains substantial. The Armed Forces Regression Study was a randomized, double-blind, placebo-controlled t ... Full text Link to item Cite

Disease management produces limited quality-of-life improvements in patients with congestive heart failure: evidence from a randomized trial in community-dwelling patients.

Journal Article Am J Manag Care · November 2005 BACKGROUND: Disease management programs are reported to improve clinical and quality-of-life outcomes while simultaneously lowering healthcare costs. OBJECTIVE: To examine the effectiveness of disease management in improving health-related quality of life ... Link to item Cite

The response to inhaled nitric oxide in patients with pulmonary artery hypertension is not masked by baseline vasodilator use.

Journal Article Am Heart J · October 2005 BACKGROUND: Assessment of pulmonary vasodilator responsiveness is important in determining the prognosis and management of patients with pulmonary hypertension. Many patients, however, are already on vasodilators at the time of testing. It is unclear if th ... Full text Link to item Cite

Conversion to atorvastatin in patients intolerant or refractory to simvastatin therapy: the CAPISH study.

Journal Article Mayo Clin Proc · September 2005 OBJECTIVE: To examine the safety and efficacy of switching from simvastatin to atorvastatin in patients who had either an inadequate lipid-lowering response with, or an adverse reaction to, simvastatin. PATIENTS AND METHODS: The Conversion to Atorvastatin ... Full text Link to item Cite

Aggressive Treatment of High-Density Lipoprotein Cholesterol

Journal Article Annals of Internal Medicine · June 21, 2005 Full text Cite

Rationale and design of the multicenter, randomized, double-blind, placebo-controlled study to evaluate the Efficacy of Vasopressin antagonism in Heart Failure: Outcome Study with Tolvaptan (EVEREST).

Journal Article J Card Fail · May 2005 BACKGROUND: Hospitalizations for worsening heart failure due to fluid overload (congestion) are common. Agents that treat congestion without causing electrolyte abnormalities or worsening renal function are needed. Tolvaptan is an oral vasopressin (V 2 ) a ... Full text Link to item Cite

Effects of pre-analytical variables on the anti-activated factor X chromogenic assay when monitoring unfractionated heparin and low molecular weight heparin anticoagulation.

Journal Article Blood Coagul Fibrinolysis · April 2005 The purpose of this study was to determine whether the anti-activated factor X (anti-FXa) assay is less affected by pre-analytical variables in monitoring patients on unfractionated heparin (UFH) and low molecular weight heparin (LMWH) than the activated p ... Full text Link to item Cite

A randomized trial of a strategy for increasing high-density lipoprotein cholesterol levels: effects on progression of coronary heart disease and clinical events.

Journal Article Ann Intern Med · January 18, 2005 BACKGROUND: The high-density lipoprotein (HDL) cholesterol level is a strong predictor of cardiovascular events in epidemiologic studies. Until recently, it has been less extensively studied as a therapeutic target. OBJECTIVE: To assess the angiographic an ... Full text Link to item Cite

Regimen to increase HDL cholesterol levels may improve cholesterol profiles

Journal Article Evidence-based Cardiovascular Medicine · January 1, 2005 Full text Cite

The emerging role of percutaneous intervention in adults with congenital heart disease.

Journal Article Rev Cardiovasc Med · 2005 Adults with congenital heart disease (CHD) constitute a patient population that has grown rapidly, due to advances in diagnosis and treatment of children with CHD. Though ideally served by cardiologists with advanced training in congenital conditions, adul ... Link to item Cite

Long-term healthcare and cost outcomes of disease management in a large, randomized, community-based population with heart failure.

Journal Article Circulation · December 7, 2004 BACKGROUND: Because of the prevalence and expense of congestive heart failure (CHF), significant efforts have been made to develop disease management (DM) programs that will improve clinical and financial outcomes. The effectiveness of such programs in a l ... Full text Link to item Cite

Effects of Pre-Analytical Variables on the Anti-FXa Chromogenic Assay when Monitoring Unfractionated Heparin and Low Molecular Weight Heparin Anticoagulation.

Conference Blood · November 16, 2004 AbstractIntroduction: The purpose of this study was to determine if the anti-FXa (FXa)assay is less affected by pre-analytical variables in monitoring patients on unfractionated heparin (UFH) and low molecul ... Full text Cite

Cardiopulmonary and mental health diagnoses surrounding the September 11 terrorist acts in a military population.

Journal Article Mil Med · September 2004 BACKGROUND: In addition to psychological disorders, emotional stress can trigger a chain of neurohumoral imbalances that can manifest as cardiopulmonary complaints. No studies were identified that used objective clinical data on complaints after the terror ... Full text Link to item Cite

Adverse Impact of Diastolic Heart Failure on Exercise Tolerance

Conference Journal of Cardiac Failure · August 2004 Full text Cite

Usefulness of percutaneous balloon mitral commissurotomy in preventing the development of atrial fibrillation in patients with mitral stenosis.

Journal Article Am J Cardiol · April 1, 2004 A prospective cohort of patients with mitral stenosis and no history of atrial arrhythmias showed no decrease in the incidence of atrial fibrillation (AF) after successful versus unsuccessful Inoue balloon percutaneous balloon mitral valve commissurotomy. ... Full text Link to item Cite

"It's hard to make predictions, especially about the future".

Journal Article Catheter Cardiovasc Interv · March 2004 Full text Link to item Cite

Matrix metalloproteinases in patients with myocardial infarction and percutaneous revascularization.

Journal Article J Interv Cardiol · February 2004 BACKGROUND: Extracellular matrix remodeling is a component of coronary artery disease (CAD). Matrix metalloproteinases (MMPs) are enzymes involved in extracellular matrix degradation. The extrapolation of the role MMPs play in the clinical setting of acute ... Full text Link to item Cite

Optimal timing of hydration to erase contrast-associated nephropathy: the OTHER CAN study.

Journal Article J Invasive Cardiol · December 2003 Intravascular contrast agents remain a common cause of acute renal dysfunction, and prolonged intravenous saline administration prior to contrast exposure has been recommended in patients with elevated creatinine levels. For patient convenience and to mini ... Link to item Cite

Addition of right-sided and posterior precordial leads during stress testing.

Journal Article Am Heart J · December 2003 BACKGROUND: Exercise treadmill testing has limited sensitivity for the detection of coronary artery disease, frequently requiring the addition of imaging modalities to enhance the predictive value of the test. Recently, there has been interest in using non ... Full text Link to item Cite

C-reactive protein elevation independently influences the procedural success of percutaneous balloon mitral valve commissurotomy.

Journal Article Am Heart J · December 2003 BACKGROUND: Markers of systemic inflammation including C-reactive protein (CRP) appear to predict morbidity and mortality in various clinical conditions. The presence of systemic inflammation and its impact on the procedural success of percutaneous balloon ... Full text Link to item Cite

Trained and supervised physician assistants can safely perform diagnostic cardiac catheterization with coronary angiography.

Journal Article Catheter Cardiovasc Interv · June 2003 Using a prospectively collected database of patients undergoing cardiac catheterization, we sought to compare the outcomes of procedures performed by supervised physician assistants (PAs) with those performed by supervised cardiology fellows-in-training. O ... Full text Link to item Cite

Utility of magnetic resonance imaging in cardiac venous anatomic variants.

Journal Article Cardiovasc Intervent Radiol · 2003 The incidence of persistent left superior vena cava (PLSVC) is approximately 0.5% in the general population; however, the coexistent absence of the right SVC has a reported incidence in tertiary centers of 0.1%. The vast majority of reports are limited to ... Full text Link to item Cite

Critical pathways for patients with acute chest pain at low risk.

Journal Article J Thromb Thrombolysis · April 2002 Critical pathways are predefined protocols that define the crucial steps in evaluating and treating a clinical problem to improve quality of patient care, reduce variability and enhance efficiency. Critical pathways have proliferated for a variety of diagn ... Full text Link to item Cite

Serial echocardiographic evaluation of restenosis after successful percutaneous mitral commissurotomy.

Journal Article J Am Coll Cardiol · January 16, 2002 OBJECTIVES: This study was designed to determine predictors of restenosis after successful percutaneous mitral commissurotomy (PMC) and its relationship to late clinical outcome. BACKGROUND: The restenosis rate after PMC and its relationship to late clinic ... Full text Link to item Cite

Comparison of results of percutaneous balloon mitral commissurotomy in patients aged > or = 65 years with those in patients aged < 65 years.

Journal Article Am J Cardiol · November 1, 2001 Percutaneous balloon mitral commissurotomy (PBMC) is now first-line therapy in patients with symptomatic mitral stenosis (MS) and favorable valve morphology. Unfortunately, the outcome of Medicare-aged patients undergoing this procedure has not previously ... Full text Link to item Cite

Reply

Journal Article Journal of the American College of Cardiology · October 2001 Full text Cite

Inhaled nitric oxide selectively dilates pulmonary vasculature in adult patients with pulmonary hypertension, irrespective of etiology.

Journal Article J Am Coll Cardiol · December 2000 OBJECTIVES: We sought to compare the responses of patients with pulmonary hypertension from primary and secondary causes (PPH and SPH, respectively) to inhaled nitric oxide (iNO) in the cardiac catheterization laboratory. BACKGROUND: Pulmonary hypertension ... Full text Link to item Cite

Congenital agenesis of the right pulmonary artery.

Journal Article Catheter Cardiovasc Interv · December 2000 A 44-year-old woman with recurrent pulmonary infections developed severe hemoptysis. Chest radiography revealed a hypoplastic right lung. Absence of the right pulmonary artery, a very rare congenital anomaly, was demonstrated by computed tomography and car ... Full text Link to item Cite

Cardiac rhabdomyoma in an adult patient presenting with ventricular arrhythmia.

Journal Article Chest · October 2000 Cardiac rhabdomyomas are extremely uncommon in the adult patient. We describe a previously healthy man who presented with ventricular arrhythmias resulting from a right ventricular, cardiac rhabdomyoma. Echocardiography, CT scanning, and MRI are recognized ... Full text Link to item Cite

Contrast Agents for Cardiac Angiography: Osmolality and Contrast Complications.

Journal Article Curr Interv Cardiol Rep · August 2000 Radiographic contrast agents have undergone a tremendous evolution over the past several decades. The creation of contrast agents with greater iodine carrying capacity and lower osmolality has improved imaging quality and reduced complications, including n ... Link to item Cite

Weekend and holiday exercise testing in patients with chest pain.

Journal Article J Gen Intern Med · January 1999 OBJECTIVE: To determine the outcome, safety, and possible cost savings of patients undergoing weekend or holiday exercise treadmill testing. DESIGN: Medical records of all 195 patients scheduled for weekend and holiday exercise testing were reviewed, and 7 ... Full text Link to item Cite