Trey Highland

Journal Article Journal of the Optical Society of America. A, Optics, image science, and vision · September 2025 Spectroscopic optical coherence tomography enables an accurate estimation of scatterer size by computing the correlation distance (CD) function. For calibration and accuracy verification, polystyrene spheres are commonly used as size standards. However, an ... Full text Cite

Enhanced penetration depth in optical coherence tomography and photoacoustic microscopy in vivo enabled by absorbing dye molecules

Journal Article Optica · January 20, 2025 The scattering and absorption of light within biological tissue severely limits the penetration depth of optical imaging techniques. Recently, it has been found that water-soluble, strongly absorbing dye molecules, such as tartrazine, can achieve in vivo t ... Full text Cite

Multimodal segmentation of dynamic subcellular features using quantitative phase imaging and FRET-based sensors [Invited].

Journal Article Journal of the Optical Society of America. A, Optics, image science, and vision · November 2024 Understanding cellular responses to mechanical environmental stimuli is important for cellular mechanotransduction studies. While fluorescence microscopy has been used for aiding mechanotransduction research due to its molecular sensitivity, the ability of ... Full text Cite

Utilizing quantitative phase microscopy to localize fluorescence in three dimensions via the transport of intensity equation.

Journal Article Optics letters · August 2024 We demonstrate the use of a novel, to the best of our knowledge, localization algorithm for digitally refocusing fluorescence images from a three-dimensional cell culture. Simultaneous phase and fluorescence intensity images are collected through a multimo ... Full text Cite