Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Cardiovascular Disease Fellowship, Medicine, Duke University School of Medicine 2012 - 2016
  • Research Fellow, Cardiovascular Research Center, Massachusetts General Hospital 2011 - 2012
  • Internal Medicine Residency, Massachusetts General Hospital 2008 - 2011
  • M.D., University of North Carolina at Chapel Hill School of Medicine 2008
• Research
• 

  Selected Grants

  • The Branched Chain Ketoacid Dehydrogenase Kinase-Phosphatase System as a New Regulatory Node in Myocardial Fuel Section awarded by National Institutes of Health 2018 - 2023
  • Eli Lilly Collaboration awarded by Eli Lilly and Company 2017 - 2018
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Yu, B, Flexeder, C, McGarrah, RW, Wyss, A, Morrison, AC, North, KE, Boerwinkle, E, Kastenmüller, G, Gieger, C, Suhre, K, Karrasch, S, Peters, A, Wagner, GR, Michelotti, GA, Mohney, RP, Schulz, H, and London, SJ. "Metabolomics Identifies Novel Blood Biomarkers of Pulmonary Function and COPD in the General Population." Metabolites 9, no. 4 (April 2019).  Full Text
    • Hunter, WG, McGarrah, RW, Kelly, JP, Khouri, MG, Craig, DM, Haynes, C, Felker, GM, Hernandez, AF, Velazquez, EJ, Kraus, WE, and Shah, SH. "High-Density Lipoprotein Particle Subfractions in Heart Failure With Preserved or Reduced Ejection Fraction." Journal of the American College of Cardiology 73, no. 2 (January 2019): 177-186.  Full Text
    • McGuinn, LA, Schneider, A, McGarrah, RW, Ward-Caviness, C, Neas, LM, Di, Q, Schwartz, J, Hauser, ER, Kraus, WE, Cascio, WE, Diaz-Sanchez, D, and Devlin, RB. "Association of long-term PM2.5 exposure with traditional and novel lipid measures related to cardiovascular disease risk." Environment International 122 (January 2019): 193-200.  Full Text
    • Wang, Y, Christopher, BA, Wilson, KA, Muoio, D, McGarrah, RW, Brunengraber, H, and Zhang, G-F. "Propionate-induced changes in cardiac metabolism, notably CoA trapping, are not altered by l-carnitine." American Journal of Physiology. Endocrinology and Metabolism 315, no. 4 (October 2018): E622-E633.  Full Text
    • White, PJ, McGarrah, RW, Grimsrud, PA, Tso, S-C, Yang, W-H, Haldeman, JM, Grenier-Larouche, T, An, J, Lapworth, AL, Astapova, I, Hannou, SA, George, T, Arlotto, M, Olson, LB, Lai, M, Zhang, G-F, Ilkayeva, O, Herman, MA, Wynn, RM, Chuang, DT, and Newgard, CB. "The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase." Cell Metabolism 27, no. 6 (June 2018): 1281-1293.e7.  Full Text
    • Duscha, BD, Piner, LW, Patel, MP, Craig, KP, Brady, M, McGarrah, RW, Chen, C, and Kraus, WE. "Effects of a 12-week mHealth program on peak VO2 and physical activity patterns after completing cardiac rehabilitation: A randomized controlled trial." American Heart Journal 199 (May 2018): 105-114.  Full Text
    • McGarrah, RW, Crown, SB, Zhang, G-F, Shah, SH, and Newgard, CB. "Cardiovascular Metabolomics." Circulation Research 122, no. 9 (April 2018): 1238-1258. (Review)  Full Text
    • Sarzynski, MA, Ruiz-Ramie, JJ, Barber, JL, Slentz, CA, Apolzan, JW, McGarrah, RW, Harris, MN, Church, TS, Borja, MS, He, Y, Oda, MN, Martin, CK, Kraus, WE, and Rohatgi, A. "Effects of Increasing Exercise Intensity and Dose on Multiple Measures of HDL (High-Density Lipoprotein) Function." Arteriosclerosis, Thrombosis, and Vascular Biology 38, no. 4 (April 2018): 943-952.  Full Text
    • McGarrah, RW, and Shah, SH. "Integrative Omics: Harnessing the Proteome to Maximize the Potential of the Genome." Circulation 137, no. 11 (March 2018): 1173-1175.  Full Text
    • McGarrah, RW. "Metabolic Anthropology: Selection Pressure Shapes Fatty Acid Metabolism in Greenlandic Inuit Populations." Circulation. Cardiovascular genetics 10, no. 3 (June 2017).  Full Text
    • McGarrah, RW, Kelly, JP, Craig, DM, Haynes, C, Jessee, RC, Huffman, KM, Kraus, WE, and Shah, SH. "A Novel Protein Glycan-Derived Inflammation Biomarker Independently Predicts Cardiovascular Disease and Modifies the Association of HDL Subclasses with Mortality." Clinical Chemistry 63, no. 1 (January 2017): 288-296.  Full Text
    • McGarrah, RW, Slentz, CA, and Kraus, WE. "The Effect of Vigorous- Versus Moderate-Intensity Aerobic Exercise on Insulin Action." Current Cardiology Reports 18, no. 12 (December 2016): 117-null. (Review)  Full Text
    • McGarrah, RW, and Shah, SH. "Exomes, Proteins, and Cardiovascular Disease: Making Sense of the Signals." Circulation. Cardiovascular Genetics 9, no. 4 (August 2016): 318-319.  Full Text
    • McGarrah, RW. "Refocusing the AIM on HDL in the metabolic syndrome." Atherosclerosis 251 (August 2016): 531-533.  Full Text
    • Hunter, WG, Kelly, JP, McGarrah, RW, Khouri, MG, Craig, D, Haynes, C, Ilkayeva, O, Stevens, RD, Bain, JR, Muehlbauer, MJ, Newgard, CB, Felker, GM, Hernandez, AF, Velazquez, EJ, Kraus, WE, and Shah, SH. "Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure." Journal of the American Heart Association 5, no. 8 (July 29, 2016).  Full Text  Open Access Copy
    • Samad, Z, Vora, AN, Dunning, A, Schulte, PJ, Shaw, LK, Al-Enezi, F, Ersboll, M, McGarrah, RW, Vavalle, JP, Shah, SH, Kisslo, J, Glower, D, Harrison, JK, and Velazquez, EJ. "Aortic valve surgery and survival in patients with moderate or severe aortic stenosis and left ventricular dysfunction." European Heart Journal 37, no. 28 (July 2016): 2276-2286.  Full Text
    • White, PJ, Lapworth, AL, An, J, Wang, L, McGarrah, RW, Stevens, RD, Ilkayeva, O, George, T, Muehlbauer, MJ, Bain, JR, Trimmer, JK, Brosnan, MJ, Rolph, TP, and Newgard, CB. "Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export." Molecular Metabolism 5, no. 7 (July 2016): 538-551.  Full Text
    • Hunter, WG, Kelly, JP, McGarrah, RW, Kraus, WE, and Shah, SH. "Metabolic Dysfunction in Heart Failure: Diagnostic, Prognostic, and Pathophysiologic Insights From Metabolomic Profiling." Current Heart Failure Reports 13, no. 3 (June 2016): 119-131. (Review)  Full Text
    • McGarrah, RW, Craig, DM, Haynes, C, Dowdy, ZE, Shah, SH, and Kraus, WE. "High-density lipoprotein subclass measurements improve mortality risk prediction, discrimination and reclassification in a cardiac catheterization cohort." Atherosclerosis 246 (March 2016): 229-235.  Full Text
    • Ahmad, T, Kelly, JP, McGarrah, RW, Hellkamp, AS, Fiuzat, M, Testani, JM, Wang, TS, Verma, A, Samsky, MD, Donahue, MP, Ilkayeva, OR, Bowles, DE, Patel, CB, Milano, CA, Rogers, JG, Felker, GM, O'Connor, CM, Shah, SH, and Kraus, WE. "Prognostic Implications of Long-Chain Acylcarnitines in Heart Failure and Reversibility With Mechanical Circulatory Support." Journal of the American College of Cardiology 67, no. 3 (January 2016): 291-299.  Full Text
    • Cooper, LB, Doll, JA, Kelly, JP, McGarrah, RW, Randolph, TC, Sivak, JA, Vora, AN, and Zeitler, EP. "A Company of Equals: Success Through Friendship in Fellowship." Journal of the American College of Cardiology 66, no. 5 (August 2015): 589-591.  Full Text
    • McGarrah, RW, Ahmad, T, Koeberl, DD, and Patel, CB. "The heart is just a muscle." Circulation 131, no. 10 (March 2015): 914-922.  Full Text
    • McGarrah, R, Craig, DM, Haynes, C, Hauser, E, Newgard, CB, Gregory, SG, Kraus, W, and Shah, S. "OMICS PROFILING HIGHLIGHTS ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION AND UBIQUITIN PROTEASOME PATHWAYS IN INSULIN RESISTANCE AND GLYCEMIC CONTROL." Journal of the American College of Cardiology 63, no. 12 (April 2014): A1600-A1600.  Full Text
    • Rottiers, V, Obad, S, Petri, A, McGarrah, R, Lindholm, MW, Black, JC, Sinha, S, Goody, RJ, Lawrence, MS, deLemos, AS, Hansen, HF, Whittaker, S, Henry, S, Brookes, R, Najafi-Shoushtari, SH, Chung, RT, Whetstine, JR, Gerszten, RE, Kauppinen, S, and Näär, AM. "Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR." Science Translational Medicine 5, no. 212 (November 2013): 212ra162-null.  Full Text
    • Kakoki, M, McGarrah, RW, Kim, H-S, and Smithies, O. "Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury." Proceedings of the National Academy of Sciences 104, no. 18 (May 1, 2007): 7576-7581.  Full Text

  • Conference Papers

    • McGarrah, RW, Navar, AM, Giamberardino, S, Coles, A, Kwee, LC, Hoffmann, U, Ginsburg, GS, Kraus, WE, Douglas, PS, and Shah, SH. "NMR Lipoprotein Profiling Identifies HDL Subclasses Associated With Obstructive CAD: Insights From the PROMISE Clinical Trial." Scientific Sessions of the American-Heart-Association / Resuscitation Science Symposium. Anaheim, CA. November 11, 2017 - November 15, 2017.: LIPPINCOTT WILLIAMS & WILKINS, November 14, 2017.  Link to Item
    • Hunter, WG, Kelly, JP, McGarrah, RW, Khouri, MG, Craig, DM, Haynes, C, Ilkayeva, O, Stevens, RD, Muehlbauer, MJ, Newgard, CB, Felker, GM, Hernandez, AF, Velazquez, EJ, Kraus, WE, and Shah, SH. "Plasma amino acid concentrations are independently associated with adverse outcomes in heart failure and preserved ejection fraction: prognostic utility of amino acid profiles in HFpEF." August 1, 2016.  Link to Item
    • Hunter, W, McGarrah, RW, Kelly, JP, Haynes, C, Velazquez, EJ, Kraus, WE, and Shah, SH. "Circulating High-Density Lipoprotein Particle Profiles Are Independently Associated With Heart Failure With Preserved Ejection Fraction and Predict Adverse Clinical Outcomes." The Japanese Circulation Society, 2016.
    • Kwee, LC, Hunter, W, McGarrah, RW, Kelly, JP, Craig, DM, Shipkova, P, Reily, M, Chen, J, Chasalow, S, Hnatyshyn, S, Thompson, J, Gargalovic, P, Hernandez, AF, Felker, GM, Velazquez, EJ, Kraus, WE, and Shah, SH. "Global Metabolomic Profiling in Heart Failure With Preserved Ejection Fraction Identifies Markers of Myocardial Dysfunction." The Japanese Circulation Society, 2016.
    • Kelly, JP, Hunter, WG, McGarrah, RW, Craig, D, Haynes, C, Velazquez, EJ, Felker, GM, Hernandez, AF, Newgard, CB, Shah, SH, and Kraus, WE. "Novel Protein Glycan Inflammatory Biomarkers Predict Adverse Events in Heart Failure with Preserved Ejection Fraction." August 2015.  Full Text
    • Hunter, W, Kelly, J, Craig, D, Haynes, C, McGarrah, R, Velazquez, E, Felker, GM, Hernandez, A, Ilkayeva, O, Stevens, RD, Bain, J, Muehlbauer, M, Newgard, C, Kraus, W, and Shah, S. "METABOLOMIC PROFILING IN HEART FAILURE IDENTIFIES BIOMARKERS OF MITOCHONDRIAL FUNCTION IN PRESERVED VERSUS REDUCED EJECTION FRACTION." March 2015.  Full Text
    • Kelly, JP, Hunter, W, Craig, D, Haynes, C, McGarrah, R, Velazquez, E, Felker, M, Hernandez, A, Ilkayeva, O, Stevens, RD, Bain, J, Muehlbauer, M, Newgard, C, Kraus, W, and Shah, S. "METABOLOMIC PROFILING IDENTIFIES BIOMARKERS PREDICTING ADVERSE OUTCOMES IN PATIENTS WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION." March 2015.  Full Text
    • McGarrah, R, Craig, D, Haynes, C, Dowdy, ZE, Shah, S, and Kraus, W. "GLYCA, A NOVEL BIOMARKER OF SYSTEMIC INFLAMMATION, IMPROVES CARDIOVASCULAR RISK PREDICTION IN A HIGH-RISK CORONARY CATHETERIZATION COHORT." March 2015.  Full Text
    • McGarrah, RW, Craig, DM, Haynes, C, Dowdy, ZE, Shah, SH, and Kraus, WE. "High-density Lipoprotein Particle Concentration Has a Stronger Inverse Association With Cardiovascular Events Than High-density Lipoprotein Cholesterol in a Coronary Catheterization Population." November 26, 2013.  Link to Item
    • McGarrah, R, Shah, S, Hauser, E, Haynes, C, Winegar, D, Pourfarzib, R, and Kraus, W. "NMR-BASED LIPOPROTEIN PARTICLE PROFILING IDENTIFIES NOVEL SIGNATURES FOR CARDIOVASCULAR DISEASE." : Elsevier BV, March 2013.  Full Text
    • Hunter, W, Kelly, JP, and McGarrah, RW. "Plasma amino acid concentrations are independently associated with adverse outcomes in heart failure and preserved ejection fraction: prognostic utility of amino acid profiles in HFpEF." European Society of Cardiology Congress 2016. August 28, 2016 - August 28, 2016.
    • Kwee, LC, Hunter, W, McGarrah, RW, Kelly, JP, Craig, DM, Shipkova, P, Reily, M, Chen, J, Chasalow, S, Hnatyshyn, S, Thompson, J, Gargalovic, P, Hernandez, AF, Felker, GM, Velazquez, EJ, Kraus, WE, and Shah, SH. "Global Metabolomic Profiling in Heart Failure With Preserved Ejection Fraction Identifies Markers of Myocardial Dysfunction." American Heart Association Scientific Sessions 2016. November 14, 2016 - November 14, 2016.

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