Robert Anthony Mook Jr. | Scholars@Duke

Robert Anthony Mook Jr.
Assistant Professor in Medicine

Current Appointments & Affiliations

Assistant Professor in Medicine, Medicine, Gastroenterology, Medicine 2011

Contact Information

905 Lasalle Street , Mailbox 3256, Genetic Science Research Bldg 1, Rm1063, Durham, NC 27710
Genetic Science Research Bldg. 1 Duke Box 3256, 595 Lasalle Street, Room 1063, Durham, NC 27710
robert.mook@duke.edu (919) 889-2273

Background
Education, Training, & Certifications
- Ph.D., Columbia University College of Physicians and Surgeons 1985
Duke Appointment History
- Instructor Temporary in the Department of Medicine, Medicine, Gastroenterology, Medicine 2010 - 2011
Research
Selected Grants
- Duke Training Grant in Digestive Diseases and Nutrition awarded by National Institutes of Health 1988 - 2021
- Inhibition of Wnt/B-Catenin Signaling in Colorectal Cancer Therapy awarded by National Institutes of Health 2013 - 2019
- Inhibitors of TrkB Signaling awarded by National Institutes of Health 2016 - 2019
- Targeting the WNT/beta-catenin pathway in triple negative breast cancer awarded by Department of Defense 2013 - 2017
- Bone-targeted calcium channel agonists for osteoporosis awarded by UH Harrington Discovery Institute 2015 - 2017
- Clinical Oncology Research Career Development Program awarded by National Institutes of Health 2009 - 2015
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Mook, RA, Wang, J, Ren, X-R, Piao, H, Lyerly, HK, and Chen, W. "Identification of novel triazole inhibitors of Wnt/β-catenin signaling based on the Niclosamide chemotype." Bioorganic & Medicinal Chemistry Letters 29, no. 2 (January 2019): 317-321. Full Text
  - Wang, J, Mook, RA, Ren, X-R, Zhang, Q, Jing, G, Lu, M, Spasojevic, I, Lyerly, HK, Hsu, D, and Chen, W. "Identification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth." Bioorganic & Medicinal Chemistry 26, no. 20 (November 2018): 5435-5442. Full Text
  - Chen, W, Mook, RA, Premont, RT, and Wang, J. "Niclosamide: Beyond an antihelminthic drug." Cellular signalling 41 (January 2018): 89-96. (Review) Full Text
  - Bhattacharyya, J, Ren, X-R, Mook, RA, Wang, J, Spasojevic, I, Premont, RT, Li, X, Chilkoti, A, and Chen, W. "Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth." Nanoscale 9, no. 34 (August 2017): 12709-12717. Full Text
  - Mook, RA, Ren, X-R, Wang, J, Piao, H, Barak, LS, Kim Lyerly, H, and Chen, W. "Benzimidazole inhibitors from the Niclosamide chemotype inhibit Wnt/β-catenin signaling with selectivity over effects on ATP homeostasis." Bioorganic & medicinal chemistry 25, no. 6 (March 2017): 1804-1816. Full Text
  - Geer Wallace, MA, Kwon, D-Y, Weitzel, DH, Lee, C-T, Stephenson, TN, Chi, J-T, Mook, RA, Dewhirst, MW, Hong, J, and Fitzgerald, MC. "Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements." Journal of Proteome Research 15, no. 8 (August 2016): 2688-2696. Full Text
  - Kanju, P, Chen, Y, Lee, W, Yeo, M, Lee, SH, Romac, J, Shahid, R, Fan, P, Gooden, DM, Simon, SA, Spasojevic, I, Mook, RA, Liddle, RA, Guilak, F, and Liedtke, WB. "Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain." Scientific Reports 6 (June 2016): 26894-null. Full Text Open Access Copy
  - Ren, XR, Wang, J, Osada, T, Mook, RA, Morse, MA, Barak, LS, Lyerly, HK, and Chen, W. "Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth." Breast cancer research : BCR 17, no. 1 (December 2015): 528-.
  - Kwon, D-Y, Lee, HE, Weitzel, DH, Park, K, Lee, SH, Lee, C-T, Stephenson, TN, Park, H, Fitzgerald, MC, Chi, J-T, Mook, RA, Dewhirst, MW, Lee, YM, and Hong, J. "Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition." Journal of medicinal chemistry 58, no. 19 (October 2015): 7659-7671. Full Text
  - Mook, RA, Wang, J, Ren, X-R, Chen, M, Spasojevic, I, Barak, LS, Lyerly, HK, and Chen, W. "Structure-activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: Identification of derivatives with improved drug exposure." Bioorganic & Medicinal Chemistry 23, no. 17 (September 2015): 5829-5838. Full Text
  - Mook, RA, Chen, M, Lu, J, Barak, LS, Lyerly, HK, and Chen, W. "Small molecule modulators of Wnt/β-catenin signaling." Bioorg Med Chem Lett 23, no. 7 (April 1, 2013): 2187-2191. Full Text Link to Item
  - Rheault, TR, Stellwagen, JC, Adjabeng, GM, Hornberger, KR, Petrov, KG, Waterson, AG, Dickerson, SH, Mook, RA, Laquerre, SG, King, AJ, Rossanese, OW, Arnone, MR, Smitheman, KN, Kane-Carson, LS, Han, C, Moorthy, GS, Moss, KG, and Uehling, DE. "Discovery of dabrafenib: A selective inhibitor of Raf Kinases with antitumor activity against B-Raf-driven tumors." Acs Medicinal Chemistry Letters 4, no. 3 (March 14, 2013): 358-362. Full Text
  - Wang, J, Mook, RA, Lu, J, Gooden, DM, Ribeiro, A, Guo, A, Barak, LS, Lyerly, HK, and Chen, W. "Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling." Bioorg Med Chem 20, no. 22 (November 15, 2012): 6751-6757. Full Text Link to Item
  - Wang, J, Lu, J, Mook, RA, Zhang, M, Zhao, S, Barak, LS, Freedman, JH, Lyerly, HK, and Chen, W. "The insecticide synergist piperonyl butoxide inhibits hedgehog signaling: assessing chemical risks." Toxicological Sciences : an Official Journal of the Society of Toxicology 128, no. 2 (August 2012): 517-523. Full Text
  - Stellwagen, JC, Adjabeng, GM, Arnone, MR, Dickerson, SH, Han, C, Hornberger, KR, King, AJ, Jr, RAM, Petrov, KG, Rheault, TR, Rominger, CM, Rossanese, OW, Smitheman, KN, Waterson, AG, and Uehling, DE. "Development of potent B-Raf ^V600E inhibitors containing an arylsulfonamide headgroup." Bioorganic and Medicinal Chemistry Letters 21, no. 15 (2011): 4436-4440. Full Text
  - Wang, J, Barak, LS, Mook, RA, and Chen, W. "Glucocorticoid hedgehog agonists in neurogenesis." Vitam Horm 87 (2011): 207-215. (Review) Full Text Link to Item
  - Emmitte, KA, Adjabeng, GM, Webb Andrews, C, Badiang Alberti, JG, Bambal, R, Chamberlain, SD, Davis-Ward, RG, Dickson, HD, Hassler, DF, Hornberger, KR, Jackson, JR, Kuntz, KW, Lansing, TJ, Mook, RA, Nailor, KE, Pobanz, MA, Smith, SC, Sung, CM, and Cheung, M. "Corrigendum to "Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding" [Bioorg. Med. Chem. Lett. 19 (2009) 1694] (DOI:10.1016/j.bmcl.2009.01.094)." Bioorganic and Medicinal Chemistry Letters 19, no. 9 (May 1, 2009): 2604-null. Full Text
  - Emmitte, KA, Adjabeng, GM, Andrews, CW, Alberti, JGB, Bambal, R, Chamberlain, SD, Davis-Ward, RG, Dickson, HD, Hassler, DF, Hornberger, KR, Jackson, JR, Kuntz, KW, Lansing, TJ, Mook, RA, Nailor, KE, Pobanz, MA, Smith, SC, Sung, C-M, and Cheung, M. "Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding." Bioorganic & Medicinal Chemistry Letters 19, no. 6 (March 2009): 1694-1697. Full Text
  - Emmitte, KA, Andrews, CW, Badiang, JG, Davis-Ward, RG, Dickson, HD, Drewry, DH, Emerson, HK, Epperly, AH, Hassler, DF, Knick, VB, Kuntz, KW, Lansing, TJ, Linn, JA, Mook, RA, Nailor, KE, Salovich, JM, Spehar, GM, and Cheung, M. "Discovery of thiophene inhibitors of polo-like kinase." Bioorganic & Medicinal Chemistry Letters 19, no. 3 (February 2009): 1018-1021. Full Text
  - Chamberlain, SD, Redman, AM, Wilson, JW, Deanda, F, Shotwell, JB, Gerding, R, Lei, H, Yang, B, Stevens, KL, Hassell, AM, Shewchuk, LM, Leesnitzer, MA, Smith, JL, Sabbatini, P, Atkins, C, Groy, A, Rowand, JL, Kumar, R, Jr, RAM, Moorthy, G, and Patnaik, S. "Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity." Bioorganic and Medicinal Chemistry Letters 19, no. 2 (2009): 360-364. Full Text
  - Chamberlain, SD, Wilson, JW, Deanda, F, Patnaik, S, Redman, AM, Yang, B, Shewchuk, L, Sabbatini, P, Leesnitzer, MA, Groy, A, Atkins, C, Gerding, R, Hassell, AM, Lei, H, Jr, RAM, Moorthy, G, Rowand, JL, Stevens, KL, Kumar, R, and Shotwell, JB. "Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines: Potent inhibitors of the IGF-1R receptor tyrosine kinase." Bioorganic and Medicinal Chemistry Letters 19, no. 2 (2009): 469-473. Full Text
  - Emmitte, KA, Wilson, BJ, Baum, EW, Emerson, HK, Kuntz, KW, Nailor, KE, Salovich, JM, Smith, SC, Cheung, M, Gerding, RM, Stevens, KL, Uehling, DE, Jr, RAM, Moorthy, GS, Dickerson, SH, Hassell, AM, Leesnitzer, MA, Shewchuk, LM, Groy, A, Rowand, JL, Anderson, K, Atkins, CL, Yang, J, Sabbatini, P, and Kumar, R. "Discovery and optimization of imidazo[1,2-a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R)." Bioorganic and Medicinal Chemistry Letters 19, no. 3 (2009): 1004-1008. Full Text
  - Wood, ER, Shewchuk, L, Hassel, A, Nichols, J, Truesdale, AT, Smith, D, Carter, HL, Weaver, K, Barrett, G, Leesnitzer, T, Alvarez, E, Bardera, AI, Alamillo, A, Cantizani, J, Martin, J, Smith, GK, Jensen, DE, Xie, H, Mook, R, Kumar, R, and Kuntz, K. "Discovery of an inhibitor of insulin-like growth factor 1 receptor activation: Implications for cellular potency and selectivity over insulin receptor." Biochemical Pharmacology 78, no. 12 (2009): 1438-1447. Full Text
  - Harris, PA, Boloor, A, Cheung, M, Kumar, R, Crosby, RM, Davis-Ward, RG, Epperly, AH, Hinkle, KW, Hunter, RN, Johnson, JH, Knick, VB, Laudeman, CP, Luttrell, DK, Mook, RA, Nolte, RT, Rudolph, SK, Szewczyk, JR, Truesdale, AT, Veal, JM, Wang, L, and Stafford, JA. "Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor." Journal of Medicinal Chemistry 51, no. 15 (August 2008): 4632-4640. Full Text
  - Cheung, M, Kuntz, KW, Pobanz, M, Salovich, JM, Wilson, BJ, III, CWA, Shewchuk, LM, Epperly, AH, Hassler, DF, Leesnitzer, MA, Smith, JL, Smith, GK, Lansing, TJ, and Jr, RAM. "Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1." Bioorganic and Medicinal Chemistry Letters 18, no. 23 (2008): 6214-6217. Full Text
  - Lansing, TJ, McConnell, RT, Duckett, DR, Spehar, GM, Knick, VB, Hassler, DF, Noro, N, Furuta, M, Emmitte, KA, Gilmer, TM, Jr, RAM, and Cheung, M. "In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1." Molecular Cancer Therapeutics 6, no. 2 (2007): 450-459. Full Text
  - Petrov, KG, Zhang, Y-M, Carter, M, Cockerill, GS, Dickerson, S, Gauthier, CA, Guo, Y, Mook, RA, Rusnak, DW, Walker, AL, Wood, ER, and Lackey, KE. "Optimization and SAR for dual ErbB-1/ErbB-2 tyrosine kinase inhibition in the 6-furanylquinazoline series." Bioorganic & Medicinal Chemistry Letters 16, no. 17 (September 2006): 4686-4691. Full Text
  - Savarese, JJ, Belmont, MR, Hashim, MA, Mook, RA, Boros, EE, Samano, V, Patel, SS, Feldman, PL, Schultz, J-AI, McNulty, M, Spitzer, T, Cohn, DL, Morgan, P, and Wastila, WB. "Preclinical pharmacology of GW280430A (AV430A) in the rhesus monkey and in the cat: a comparison with mivacurium." Anesthesiology 100, no. 4 (April 2004): 835-845. Full Text
  - Heerdt, PM, Kang, R, The', A, Hashim, M, Jr, RJM, and Savarese, JJ. "Cardiopulmonary Effects of the Novel Neuromuscular Blocking Drug GW280430A (AV430A) in Dogs." Anesthesiology 100, no. 4 (2004): 846-851. Full Text
  - Boros, EE, Samano, V, Ray, JA, Thompson, JB, Jung, DK, Kaldor, I, Koble, CS, Martin, MT, Styles, VL, Mook, RA, Feldman, PL, Savarese, JJ, Belmont, MR, Bigham, EC, Boswell, GE, Hashim, MA, Patel, SS, Wisowaty, JC, Bowers, GD, Moseley, CL, Walsh, JS, Reese, MJ, Rutkowske, RD, Sefler, AM, and Spitzer, TD. "Neuromuscular blocking activity and therapeutic potential of mixed-tetrahydroisoquinolinium halofumarates and halosuccinates in rhesus monkeys." Journal of Medicinal Chemistry 46, no. 12 (June 2003): 2502-2515. Full Text
  - Kaldor, I, Feldman, PL, Jr, RAM, Ray, JA, Samano, V, Sefier, AM, Thompson, JB, Travis, BR, and Boros, EE. "Stereocontrolled synthesis of cis-dibenzoquinolizine chlorofumarates: Curare-like agents of ultrashort duration." Journal of Organic Chemistry 66, no. 10 (2001): 3495-3501. Full Text
  - Brown, KK, Henke, BR, Blanchard, SG, Cobb, JE, Mook, R, Kaldor, I, Kliewer, SA, Lehmann, JM, Lenhard, JM, Harrington, WW, Novak, PJ, Faison, W, Binz, JG, Hashim, MA, Oliver, WO, Brown, HR, Parks, DJ, Plunket, KD, Tong, WQ, Menius, JA, Adkison, K, Noble, SA, and Willson, TM. "A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat." Diabetes 48, no. 7 (July 1999): 1415-1424. Full Text
  - Boros, EE, Bigham, EC, Boswell, GE, Mook, J, Patel, SS, Savarese, JJ, Ray, JA, Thompson, JB, Hashim, MA, Wisowaty, JC, Feldman, PL, and Samano, V. "Erratum: Bis- and mixed-tetrahydroisoquinolinium chlorofumarates: New ultra-short-acting nondepolarizing neuromuscular blockers (Journal of Medicinal Chemistry (1999) 42 (207))." Journal of Medicinal Chemistry 42, no. 6 (March 25, 1999): 1114-null. Full Text
  - Boros, EE, Bigham, EC, Boswell, GE, Jr, MRA, Patel, SS, Savarese, JJ, Ray, JA, Thompson, JB, Hashim, MA, Wisowaty, JC, Feldman, PL, and Samano, V. "Bis- and mixed-tetrahydroisoquinolinium chlorofumarates: New ultra- short-acting nondepolarizing neuromuscular blockers [2]." Journal of Medicinal Chemistry 42, no. 2 (1999): 206-209. Full Text
  - Henke, BR, Adkison, KK, Blanchard, SG, Leesnitzer, LM, Jr, RAM, Plunket, KD, Ray, JA, Roberson, C, Unwalla, R, and Willson, TM. "Synthesis and biological activity of a novel series of indole-derived PPARγ agonists." Bioorganic and Medicinal Chemistry Letters 9, no. 23 (1999): 3329-3334.
  - Samano, V, Ray, JA, Thompson, JB, Jr, RAM, Jung, DK, Koble, CS, Martin, MT, Bigham, EC, Regitz, CS, Feldman, PL, and Boros, EE. "Synthesis of Ultra-Short-Acting Neuromuscular Blocker GW 0430: A Remarkably Stereo- and Regioselective Synthesis of Mixed Tetrahydroisoquinolinium Chlorofumarates." Organic Letters 1, no. 12 (1999): 1993-1996.
  - Henke, BR, Blanchard, SG, Brackeen, MF, Brown, KK, Cobb, JE, Collins, JL, Harrington, WW, Hashim, MA, Hull-Ryde, EA, Kaldor, I, Kliewer, SA, Lake, DH, Leesnitzer, LM, Lehmann, JM, Lenhard, JM, Orband-Miller, LA, Miller, JF, Mook, RA, Noble, SA, Oliver, W, Parks, DJ, Plunket, KD, Szewczyk, JR, and Willson, TM. "N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents." Journal of Medicinal Chemistry 41, no. 25 (December 1998): 5020-5036. Full Text
  - Lewis, JG, Lin, K-Y, Kothavale, A, Flanagan, WM, Matteucci, MD, DePrince, RB, Jr, RAM, Hendren, RW, and Wagner, RW. "A serum-resistant cytofectin for cellular delivery of antisense oligodeoxynucleotides and plasmid DNA." Proceedings of the National Academy of Sciences of the United States of America 93, no. 8 (1996): 3176-3181. Full Text
  - Tian, G, Mook, RA, Moss, ML, and Frye, SV. "Mechanism of time-dependent inhibition of 5 alpha-reductases by delta 1-4-azasteroids: toward perfection of rates of time-dependent inhibition by using ligand-binding energies." Biochemistry 34, no. 41 (October 1995): 13453-13459. Full Text
  - Jr, RAM, Lackey, K, and Bennett, C. "Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase." Tetrahedron Letters 36, no. 23 (1995): 3969-3972.
  - Frye, SV, Haffner, CD, Maloney, PR, Jr, RAM, Jr, GFD, Hiner, RN, Cribbs, CM, Wheeler, TN, Ray, JA, Andrews, RC, Batchelor, KW, Bramson, HN, Stuart, JD, Schweiker, SL, Arnold, JV, Croom, S, Bickett, DM, Moss, ML, Tian, G, Unwalla, RJ, Lee, FW, Tippin, TK, James, MK, Grizzle, MK, Long, JE, and Schuster, SV. "6-Azasteroids: Structure-activity relationships for inhibition of type 1 and 2 human 5α-reductase and human adrenal 3β-hydroxy-Δ⁵-steroid dehydrogenase/3-keto-Δ⁵-steroid isomerase." Journal of Medicinal Chemistry 37, no. 15 (1994): 2352-2360.
  - Frye, SV, Haffner, CD, Maloney, PR, Jr, RAM, Jr, GFD, Hiner, RN, Batchelor, KW, Bramson, HN, Stuart, JD, Schweiker, SL, Arnold, JV, Bickett, DM, Moss, ML, Tian, G, Unwalla, RJ, Lee, FW, Tippin, TK, James, MK, Grizzle, MK, Long, JE, and Schuster, SV. "6-azasteroids: Potent dual inhibitors of human type 1 and 2 steroid 5α-reductase." Journal of Medicinal Chemistry® 36, no. 26 (1993): 4313-4315.
  - Mook, RA. "Purification of trifluoroacetic anhydride [1]." Chemical and Engineering News 65, no. 13 (December 1, 1987): 2-null. (Letter)
  - Stork, G, and Mook, R. "Vinyl Radical Cyclizations Mediated by the Addition of Stannyl Radicals to Triple Bonds." Journal of the American Chemical Society 109, no. 9 (April 1, 1987): 2829-2831. Full Text
  - Stork, G, and Mook, R. "Five vs six membered ring formation in the vinyl radical cyclization." Tetrahedron Letters 27, no. 38 (January 1, 1986): 4529-4532. Full Text
  - Stork, G, and Mook, R. "Vinyl radical cyclization. 2. Dicyclization via selective formation of unsaturated vinyl radicals by intramolecular addition to triple bonds. Applications to the synthesis of butenolides and furans." Journal of the American Chemical Society 105, no. 11 (June 1983): 3720-3722. Full Text
  - Stork, G, Mook, R, Biller, SA, and Rychnovsky, SD. "Free-Radical Cyclization of Bromoacetals. Use in the Construction of Bicyclic Acetals and Lactones." Journal of the American Chemical Society 105, no. 11 (January 1, 1983): 3741-3742. (Letter) Full Text

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles