Current Appointments & Affiliations
Assistant Professor in Medicine
·
2021 - Present
Medicine, Gastroenterology,
Medicine
Recent Publications
Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy.
Journal Article Biochem J · February 8, 2019 The Wnt signaling pathway, known for regulating genes critical to normal embryonic development and tissue homeostasis, is dysregulated in many types of cancer. Previously, we identified that the anthelmintic drug niclosamide inhibited Wnt signaling by prom ... Full text Link to item CiteIdentification of novel triazole inhibitors of Wnt/β-catenin signaling based on the Niclosamide chemotype.
Journal Article Bioorg Med Chem Lett · January 15, 2019 Dysregulation of the Wnt signaling pathway is an underlying mechanism in multiple diseases, particularly in cancer. Until recently, identifying agents that target this pathway has been difficult and as a result, no approved drugs exist that specifically ta ... Full text Link to item CiteIdentification of DK419, a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth.
Journal Article Bioorg Med Chem · November 1, 2018 The Wnt signaling pathway is critical for normal tissue development and is an underlying mechanism of disease when dysregulated. Previously, we reported that the drug Niclosamide inhibits Wnt/β-catenin signaling by decreasing the cytosolic levels of Dishev ... Full text Link to item CiteRecent Grants
Small molecule inhibitors of TrkB Signaling
ResearchAssistant Research Professor · Awarded by National Institute of Neurological Disorders and Stroke · 2023 - 2025Treatment of radiation proctitis in prostate cancer patients with a novel inducer of autophagy
ResearchCo Investigator · Awarded by Department of Defense · 2020 - 2023Inhibition of Wnt/B-Catenin Signaling in Colorectal Cancer Therapy
ResearchCo Investigator · Awarded by National Institutes of Health · 2013 - 2019View All Grants
Education, Training & Certifications
Columbia University, College of Physicians and Surgeons ·
1985
Ph.D.