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Robert D. Pearlstein

Assistant Professor Emeritus in Neurosurgery
Neurosurgery
Box 3388 Med Ctr, Durham, NC 27710
136 Sands Bldg, Durham, NC 27710

Current Appointments & Affiliations


Assistant Professor Emeritus in Neurosurgery · 2018 - Present Neurosurgery, Neurosurgery

Recent Publications


Sustained functional improvement by hepatocyte growth factor-like small molecule BB3 after focal cerebral ischemia in rats and mice.

Journal Article J Cereb Blood Flow Metab · June 2015 Hepatocyte growth factor (HGF), efficacious in preclinical models of acute central nervous system injury, is burdened by administration of full-length proteins. A multiinstitutional consortium investigated the efficacy of BB3, a small molecule with HGF-lik ... Full text Open Access Link to item Cite

Metalloporphyrins as therapeutic catalytic oxidoreductants in central nervous system disorders.

Journal Article Antioxid Redox Signal · May 20, 2014 SIGNIFICANCE: Metalloporphyrins, characterized by a redox-active transitional metal (Mn or Fe) coordinated to a cyclic porphyrin core ligand, mitigate oxidative/nitrosative stress in biological systems. Side-chain substitutions tune redox properties of met ... Full text Open Access Link to item Cite

Superoxide dismutase mimic, MnTE-2-PyP(5+) ameliorates acute and chronic proctitis following focal proton irradiation of the rat rectum.

Journal Article Redox Biol · 2013 Radiation proctitis, an inflammation and damage to the lower part of colon, is a common adverse event of the radiotherapy of tumors in the abdominal and pelvic region (colon, prostate, cervical). Several Mn(III) porphyrin-based superoxide dismutase mimics ... Full text Link to item Cite
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Recent Grants


Xenon As A Therapeutic in Experimental Intracerebral Hemorrhage

ResearchSignificant Contributor · Awarded by National Institutes of Health · 2015 - 2018

Radiation Medicine Central Nervous System Studies Phase II

ResearchPrincipal Investigator · Awarded by Loma Linda University · 2016 - 2016

Radiation Medicine Central Nervous System Studies Phase II

ResearchPrincipal Investigator · Awarded by Loma Linda University · 2015 - 2016

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Education, Training & Certifications


University of North Carolina, Chapel Hill · 1983 Ph.D.
University of North Carolina, Chapel Hill · 1981 M.S.