Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of North Carolina at Chapel Hill 1983
  • M.S., University of North Carolina at Chapel Hill 1981
• 

  Duke Appointment History

  • Assistant Professor in Neurosurgery, Neurosurgery, Neurosurgery 2006 - 2018
  • Assistant Research Professor in Surgery, Neurosurgery, Neurosurgery 1998 - 2006
• Expertise
• 

  Global Scholarship

  • Research

    • Afghanistan (Country) 
• Research
• 

  Selected Grants

  • Xenon As A Therapeutic in Experimental Intracerebral Hemorrhage awarded by National Institutes of Health 2015 - 2018
  • Radiation Medicine Central Nervous System Studies Phase II awarded by Loma Linda University 2016
  • Radiation Medicine Central Nervous System Studies Phase II awarded by Loma Linda University 2015 - 2016
  • Technology Support for Combat Related Medical Infrared Imaging in Afghanistan awarded by Air Force Office of Scientific Research 2010 - 2012
  • Technology Support for Combat Related Medical Infrared Imaging in Iraq awarded by Air Force Office of Scientific Research 2007 - 2008
  • Biomedical and Biological Research Applications of a Storage-Ring Free-Electron Laser awarded by Air Force Office of Scientific Research 2000 - 2008
  • Anesthetics, GABA and the Injured Brain awarded by National Institutes of Health 2003 - 2008
  • Extracellular Oxygen Radicals and Ischemic Brain Injury awarded by National Institutes of Health 2000 - 2003
  • Center for FEL Research in the Medical, Biological, and Materials Sciences awarded by Air Force Office of Scientific Research 2000 - 2001
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Chaparro, Rafael E., Miwa Izutsu, Toshihiro Sasaki, Huaxin Sheng, Yi Zheng, Homa Sadeghian, Tao Qin, et al. “Sustained functional improvement by hepatocyte growth factor-like small molecule BB3 after focal cerebral ischemia in rats and mice.” J Cereb Blood Flow Metab 35, no. 6 (June 2015): 1044–53. https://doi.org/10.1038/jcbfm.2015.23.
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    • Sheng, Huaxin, Raphael E. Chaparro, Toshihiro Sasaki, Miwa Izutsu, Robert D. Pearlstein, Artak Tovmasyan, and David S. Warner. “Metalloporphyrins as therapeutic catalytic oxidoreductants in central nervous system disorders.” Antioxid Redox Signal 20, no. 15 (May 20, 2014): 2437–64. https://doi.org/10.1089/ars.2013.5413.
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    • Archambeau, John O., Artak Tovmasyan, Robert D. Pearlstein, James D. Crapo, and Ines Batinic-Haberle. “Superoxide dismutase mimic, MnTE-2-PyP(5+) ameliorates acute and chronic proctitis following focal proton irradiation of the rat rectum.” Redox Biology 1 (January 2013): 599–607. https://doi.org/10.1016/j.redox.2013.10.002.
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    • Yang, Wei, Liangli Wang, Gabriele Roehn, Robert D. Pearlstein, Francis Ali-Osman, Hongjie Pan, Roland Goldbrunner, Matthew Krantz, Christoph Harms, and Wulf Paschen. “Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival.” Cancer Sci 104, no. 1 (January 2013): 70–77. https://doi.org/10.1111/cas.12047.
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    • Sheng, Siyuan P., Beilei Lei, Michael L. James, Christopher D. Lascola, Talaignair N. Venkatraman, Jin Yong Jung, Mervyn Maze, et al. “Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage.” Anesthesiology 117, no. 6 (December 2012): 1262–75. https://doi.org/10.1097/ALN.0b013e3182746b81.
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    • Finch, A. S., M. Moldovan, J. Frank, R. Bagnell, L. M. Katz, and R. D. Pearlstein. “Transient mild hypothermia differentially alters mitotic activity in normal and post-ischemic hippocampal slices from neonatal rats.” Journal of Thermal Biology 35, no. 4 (May 1, 2010): 189–96. https://doi.org/10.1016/j.jtherbio.2010.03.003.
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    • Makinde, Adeola Y., Asma Rizvi, James D. Crapo, Robert D. Pearlstein, James M. Slater, and Daila S. Gridley. “A metalloporphyrin antioxidant alters cytokine responses after irradiation in a prostate tumor model.” Radiat Res 173, no. 4 (April 2010): 441–52. https://doi.org/10.1667/RR1765.1.
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    • Pearlstein, Robert D., Yoshinori Higuchi, Maria Moldovan, Kwame Johnson, Shiro Fukuda, Daila S. Gridley, James D. Crapo, David S. Warner, and James M. Slater. “Metalloporphyrin antioxidants ameliorate normal tissue radiation damage in rat brain.” Int J Radiat Biol 86, no. 2 (February 2010): 145–63. https://doi.org/10.3109/09553000903419965.
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    • Sheng, Huaxin, Wei Yang, Shiro Fukuda, Hubert M. Tse, Wulf Paschen, Kwame Johnson, Ines Batinic-Haberle, et al. “Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat.” Free Radic Biol Med 47, no. 7 (October 1, 2009): 917–23. https://doi.org/10.1016/j.freeradbiomed.2009.05.039.
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    • Wagner, W., A. Sokolow, R. Pearlstein, and G. Edwards. “Thermal vapor bubble and pressure dynamics during infrared laser ablation of tissue.” Applied Physics Letters 94, no. 1 (January 19, 2009). https://doi.org/10.1063/1.3063127.
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    • Makinde, Adeola Y., Xian Luo-Owen, Asma Rizvi, James D. Crapo, Robert D. Pearlstein, James M. Slater, and Daila S. Gridley. “Effect of a metalloporphyrin antioxidant (MnTE-2-PyP) on the response of a mouse prostate cancer model to radiation.” Anticancer Res 29, no. 1 (January 2009): 107–18.
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    • Kittle, David, Barbara Holshouser, James M. Slater, Bob D. Guenther, Nikos P. Pitsianis, and Robert D. Pearlstein. “Technical note: rapid prototyping of 3D grid arrays for image guided therapy quality assurance.” Med Phys 35, no. 12 (December 2008): 5708–12. https://doi.org/10.1118/1.3006198.
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    • Katz, Laurence M., Varidhi Nauriyal, Shruti Nagaraj, Alex Finch, Kevin Pearlstein, Adam Szymanowski, Charles Sproule, Preston B. Rich, B. D. Guenther, and Robert D. Pearlstein. “Infrared imaging of trauma patients for detection of acute compartment syndrome of the leg.” Crit Care Med 36, no. 6 (June 2008): 1756–61. https://doi.org/10.1097/CCM.0b013e318174d800.
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    • Edwards, G., W. Wagner, A. Sokolow, and R. Pearlstein. “Pressure (mechanical) effects in infrared tissue ablation.” Progress in Biomedical Optics and Imaging  Proceedings of Spie 6854 (April 21, 2008). https://doi.org/10.1117/12.776999.
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    • Gridley, D. S., A. Y. Makinde, X. Luo, A. Rizvi, J. D. Crapo, M. W. Dewhirst, B. J. Moeller, R. D. Pearlstein, and J. M. Slater. “Radiation and a metalloporphyrin radioprotectant in a mouse prostate tumor model.” Anticancer Research 27, no. 5 A (September 1, 2007): 3101–9.
    • Edwards, G. S., R. D. Pearlstein, M. L. Copeland, M. S. Hutson, K. Latone, A. Spiro, and G. Pasmanik. “6450 nm wavelength tissue ablation using a nanosecond laser based on difference frequency mixing and stimulated Raman scattering.” Opt Lett 32, no. 11 (June 1, 2007): 1426–28. https://doi.org/10.1364/ol.32.001426.
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    • Sakai, Hiroaki, Huaxin Sheng, Robert B. Yates, Kazuyoshi Ishida, Robert D. Pearlstein, and David S. Warner. “Isoflurane provides long-term protection against focal cerebral ischemia in the rat.” Anesthesiology 106, no. 1 (January 2007): 92–99. https://doi.org/10.1097/00000542-200701000-00017.
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    • Wise-Faberowski, Lisa, Robert D. Pearlstein, and David S. Warner. “NMDA-induced apoptosis in mixed neuronal/glial cortical cell cultures: the effects of isoflurane and dizocilpine.” J Neurosurg Anesthesiol 18, no. 4 (October 2006): 240–46. https://doi.org/10.1097/00008506-200610000-00004.
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    • Elsersy, Hazem, Javier Mixco, Huaxin Sheng, Robert D. Pearlstein, and David S. Warner. “Selective gamma-aminobutyric acid type A receptor antagonism reverses isoflurane ischemic neuroprotection.” Anesthesiology 105, no. 1 (July 2006): 81–90. https://doi.org/10.1097/00000542-200607000-00016.
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    • Pearlstein, Robert D., Crystal Whitten, and Paul Haerich. “Assessing neurocognitive dysfunction in cranial radiotherapy: can cognitive event-related potentials help?” Technol Cancer Res Treat 5, no. 2 (April 2006): 109–25. https://doi.org/10.1177/153303460600500205.
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    • Leinenweber, Stephen B., Huaxin Sheng, John R. Lynch, Haichen Wang, Ines Batinić-Haberle, Daniel T. Laskowitz, James D. Crapo, Robert D. Pearlstein, and David S. Warner. “Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model.” Eur J Pharmacol 531, no. 1–3 (February 15, 2006): 126–32. https://doi.org/10.1016/j.ejphar.2005.12.031.
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    • Sakai, H., R. Yates, H. Sheng, R. Pearlstein, and D. S. Warner. “Isoflurane provides sustained neuroprotection in rats subjected to focal ischemia.” Journal of Neurosurgical Anesthesiology 18, no. 4 (January 1, 2006): 281. https://doi.org/10.1097/00008506-200610000-00030.
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    • Wise-Faberowski, Lisa, Haito Zhang, Richard Ing, Robert D. Pearlstein, and David S. Warner. “Isoflurane-induced neuronal degeneration: an evaluation in organotypic hippocampal slice cultures.” Anesth Analg 101, no. 3 (September 2005): 651–57. https://doi.org/10.1213/01.ane.0000167382.79889.7c.
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    • McAdoo, Jessica D., David S. Warner, Ron N. Goldberg, Michael P. Vitek, Robert Pearlstein, and Daniel T. Laskowitz. “Intrathecal administration of a novel apoE-derived therapeutic peptide improves outcome following perinatal hypoxic-ischemic injury.” Neurosci Lett 381, no. 3 (June 24, 2005): 305–8. https://doi.org/10.1016/j.neulet.2005.02.036.
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    • Wise-Faberowski, Lisa, Mitsuo Aono, Robert D. Pearlstein, and David S. Warner. “Apoptosis is not enhanced in primary mixed neuronal/glial cultures protected by isoflurane against N-methyl-D-aspartate excitotoxicity.” Anesth Analg 99, no. 6 (December 2004): 1708–14. https://doi.org/10.1213/01.ANE.0000136474.35627.FF.
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    • Homi, H Mayumi, Hong Yang, Robert D. Pearlstein, and Hilary P. Grocott. “Hemodilution during cardiopulmonary bypass increases cerebral infarct volume after middle cerebral artery occlusion in rats.” Anesth Analg 99, no. 4 (October 2004): 974–81. https://doi.org/10.1213/01.ANE.0000131504.90754.D0.
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    • Yokoo, Noriko, Huaxin Sheng, Javier Mixco, H Mayumi Homi, Robert D. Pearlstein, and David S. Warner. “Intraischemic nitrous oxide alters neither neurologic nor histologic outcome: a comparison with dizocilpine.” Anesth Analg 99, no. 3 (September 2004): 896–903. https://doi.org/10.1213/01.ANE.0000132973.32387.8B.
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    • Rich, Preston B., George R. Dulabon, Christelle D. Douillet, Todd M. Listwa, William P. Robinson, Ben L. Zarzaur, Robert Pearlstein, and Laurence M. Katz. “Infrared thermography: a rapid, portable, and accurate technique to detect experimental pneumothorax.” J Surg Res 120, no. 2 (August 2004): 163–70. https://doi.org/10.1016/j.jss.2004.02.026.
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    • Elsersy, Hazem, Huaxin Sheng, John R. Lynch, Maria Moldovan, Robert D. Pearlstein, and David S. Warner. “Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat.” Anesthesiology 100, no. 5 (May 2004): 1160–66. https://doi.org/10.1097/00000542-200405000-00018.
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    • Sheng, Huaxin, Haichen Wang, Hercilia M. Homi, Ivan Spasojevic, Ines Batinic-Haberle, Robert D. Pearlstein, and David S. Warner. “A no-laminectomy spinal cord compression injury model in mice.” J Neurotrauma 21, no. 5 (May 2004): 595–603. https://doi.org/10.1089/089771504774129928.
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    • Lee, Yoonki, Mitsuo Aono, Daniel Laskowitz, David S. Warner, and Robert D. Pearlstein. “Apolipoprotein E protects against oxidative stress in mixed neuronal-glial cell cultures by reducing glutamate toxicity.” Neurochemistry International 44, no. 2 (January 2004): 107–18. https://doi.org/10.1016/s0197-0186(03)00112-8.
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    • Homi, H Mayumi, Javier M. Mixco, Huaxin Sheng, Hilary P. Grocott, Robert D. Pearlstein, and David S. Warner. “Severe hypotension is not essential for isoflurane neuroprotection against forebrain ischemia in mice.” Anesthesiology 99, no. 5 (November 2003): 1145–51. https://doi.org/10.1097/00000542-200311000-00022.
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    • Aono, M., E. R. Bennett, K. S. Kim, J. R. Lynch, J. Myers, R. D. Pearlstein, D. S. Warner, and D. T. Laskowitz. “Protective effect of apolipoprotein E-mimetic peptides on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cell cultures.” Neuroscience 116, no. 2 (2003): 437–45. https://doi.org/10.1016/s0306-4522(02)00709-1.
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    • Ovelmen-Levitt, Janice, Karl D. Straub, Suzanne Hauger, Eric Szarmes, John Madey, Robert D. Pearlstein, and Blaine S. Nashold. “Brain ablation in the rat cerebral cortex using a tunable-free electron laser.” Lasers Surg Med 33, no. 2 (2003): 81–92. https://doi.org/10.1002/lsm.10197.
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    • Higuchi, Yoshinori, Gregory A. Nelson, Marcelo Vazquez, Daniel T. Laskowitz, James M. Slater, and Robert D. Pearlstein. “Apolipoprotein E expression and behavioral toxicity of high charge, high energy (HZE) particle radiation.” J Radiat Res 43 Suppl (December 2002): S219–24. https://doi.org/10.1269/jrr.43.s219.
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    • McGirt, Matthew J., John R. Lynch, Augusto Parra, Huaxin Sheng, Robert D. Pearlstein, Daniel T. Laskowitz, Dale A. Pelligrino, and David S. Warner. “Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage.” Stroke 33, no. 12 (December 2002): 2950–56. https://doi.org/10.1161/01.str.0000038986.68044.39.
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    • Bowler, Russell P., Huaxin Sheng, Jan J. Enghild, Robert D. Pearlstein, David S. Warner, and James D. Crapo. “A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke.” Free Radic Biol Med 33, no. 8 (October 15, 2002): 1141–52. https://doi.org/10.1016/s0891-5849(02)01008-0.
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    • Aono, Mitsuo, Yoonki Lee, Elfrida R. Grant, Robert A. Zivin, Robert D. Pearlstein, David S. Warner, Ellen R. Bennett, and Daniel T. Laskowitz. “Apolipoprotein E protects against NMDA excitotoxicity.” Neurobiol Dis 11, no. 1 (October 2002): 214–20. https://doi.org/10.1006/nbdi.2002.0541.
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    • Sheng, Huaxin, Jan J. Enghild, Russell Bowler, Manisha Patel, Ines Batinić-Haberle, Carla L. Calvi, Brian J. Day, Robert D. Pearlstein, James D. Crapo, and David S. Warner. “Effects of metalloporphyrin catalytic antioxidants in experimental brain ischemia.” Free Radical Biology & Medicine 33, no. 7 (October 2002): 947–61. https://doi.org/10.1016/s0891-5849(02)00979-6.
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    • McGirt, Matthew J., Augusto Parra, Huaxin Sheng, Yoshinori Higuchi, Tim D. Oury, Daniel T. Laskowitz, Robert D. Pearlstein, and David S. Warner. “Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpressing extracellular superoxide dismutase.” Stroke 33, no. 9 (September 2002): 2317–23. https://doi.org/10.1161/01.str.0000027207.67639.1e.
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    • Lockhart, Ellen M., David S. Warner, Robert D. Pearlstein, Donald H. Penning, Saeed Mehrabani, and Rose-Mary Boustany. “Allopregnanolone attenuates N-methyl-D-aspartate-induced excitotoxicity and apoptosis in the human NT2 cell line in culture.” Neuroscience Letters 328, no. 1 (August 2002): 33–36. https://doi.org/10.1016/s0304-3940(02)00448-2.
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    • Parra, Augusto, Matthew J. McGirt, Huaxin Sheng, Daniel T. Laskowitz, Robert D. Pearlstein, and David S. Warner. “Mouse model of subarachnoid hemorrhage associated cerebral vasospasm: methodological analysis.” Neurol Res 24, no. 5 (July 2002): 510–16. https://doi.org/10.1179/016164102101200276.
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    • Wainwright, M. S., H. Sheng, Y. Sato, G. Burkhard Mackensen, R. P. Steffen, R. D. Pearlstein, and D. S. Warner. “Pharmacological correction of hypothermic P50 shift does not alter outcome from focal cerebral ischemia in rats.” American Journal of Physiology  Heart and Circulatory Physiology 282, no. 5 51-5 (June 29, 2002).
    • Wainwright, Mark S., Huaxin Sheng, Yukie Sato, G Burkhard Mackensen, Robert P. Steffen, Robert D. Pearlstein, and David S. Warner. “Pharmacological correction of hypothermic P(50) shift does not alter outcome from focal cerebral ischemia in rats.” Am J Physiol Heart Circ Physiol 282, no. 5 (May 2002): H1863–70. https://doi.org/10.1152/ajpheart.00863.2001.
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    • Higuchi, Yoshinori, Blaine S. Nashold, Menno Sluijter, Eric Cosman, and Robert D. Pearlstein. “Exposure of the dorsal root ganglion in rats to pulsed radiofrequency currents activates dorsal horn lamina I and II neurons.” Neurosurgery 50, no. 4 (April 2002): 850–55. https://doi.org/10.1097/00006123-200204000-00030.
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    • Kudo, M., M. Aono, Y. Lee, G. Massey, R. D. Pearlstein, and D. S. Warner. “Effects of volatile anesthetics on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cultures.” Anesthesiology 95, no. 3 (September 2001): 756–65. https://doi.org/10.1097/00000542-200109000-00031.
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    • Mackensen, G. B., M. Patel, H. Sheng, C. L. Calvi, I. Batinic-Haberle, B. J. Day, L. P. Liang, et al. “Neuroprotection from delayed postischemic administration of a metalloporphyrin catalytic antioxidant.” J Neurosci 21, no. 13 (July 1, 2001): 4582–92.
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    • Pineda, J. A., M. Aono, H. Sheng, J. Lynch, J. C. Wellons, D. T. Laskowitz, R. D. Pearlstein, R. Bowler, J. Crapo, and D. S. Warner. “Extracellular superoxide dismutase overexpression improves behavioral outcome from closed head injury in the mouse.” J Neurotrauma 18, no. 6 (June 2001): 625–34. https://doi.org/10.1089/089771501750291864.
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    • Kudo, M., M. Aono, Y. Lee, G. Massey, R. D. Pearlstein, and D. S. Warner. “Absence of direct antioxidant effects from volatile anesthetics in primary mixed neuronal-glial cultures.” Anesthesiology 94, no. 2 (February 2001): 303–212. https://doi.org/10.1097/00000542-200102000-00021.
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    • Mackensen, G. B., B. Nellgârd, M. Kudo, H. Sheng, R. D. Pearlstein, and D. S. Warner. “Periischemic cerebral blood flow (CBF) does not explain beneficial effects of isoflurane on outcome from near-complete forebrain ischemia in rats.” Anesthesiology 93, no. 4 (October 2000): 1102–6. https://doi.org/10.1097/00000542-200010000-00035.
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    • Nellgård, B., G. B. Mackensen, J. Pineda, J. C. Wellons, R. D. Pearlstein, and D. S. Warner. “Anesthetic effects on cerebral metabolic rate predict histologic outcome from near-complete forebrain ischemia in the rat.” Anesthesiology 93, no. 2 (August 2000): 431–36. https://doi.org/10.1097/00000542-200008000-00022.
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    • Nellgård, B., G. B. Mackensen, G. Massey, R. D. Pearlstein, and D. S. Warner. “The effects of anesthetics on stress responses to forebrain ischemia and reperfusion in the rat.” Anesth Analg 91, no. 1 (July 2000): 145–51. https://doi.org/10.1097/00000539-200007000-00027.
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    • Sheng, H., M. Kudo, G. B. Mackensen, R. D. Pearlstein, J. D. Crapo, and D. S. Warner. “Mice overexpressing extracellular superoxide dismutase have increased resistance to global cerebral ischemia.” Exp Neurol 163, no. 2 (June 2000): 392–98. https://doi.org/10.1006/exnr.2000.7363.
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    • Wellons, J. C., H. Sheng, D. T. Laskowitz, G. B. Mackensen, R. D. Pearlstein, and D. S. Warner. “A comparison of strain-related susceptibility in two murine recovery models of global cerebral ischemia.” Brain Research 868, no. 1 (June 2000): 14–21. https://doi.org/10.1016/s0006-8993(00)02216-2.
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    • Pineda, J. A., I. M. Cheifetz, L. M. Katz, M. Grenn, and R. D. Pearlstein. “Critical care applications of infrared imaging.” Critical Care Medicine 27, no. 12 SUPPL. (December 1, 1999).
    • Nellgård, B. M., Y. Miura, G. B. Mackensen, R. D. Pearlstein, and D. S. Warner. “Effect of intracerebral norepinephrine depletion on outcome from severe forebrain ischemia in the rat.” Brain Res 847, no. 2 (November 20, 1999): 262–69. https://doi.org/10.1016/s0006-8993(99)02059-4.
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    • Nellgård, B., G. B. Mackensen, S. Sarraf-Yazdi, Y. Miura, R. Pearlstein, and D. S. Warner. “Pre-ischemic depletion of brain norepinephrine decreases infarct size in normothermic rats exposed to transient focal cerebral ischemia.” Neurosci Lett 275, no. 3 (November 19, 1999): 167–70. https://doi.org/10.1016/s0304-3940(99)00743-0.
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    • Carlson, J. D., R. D. Pearlstein, J. Buchholz, R. P. Iacono, and G. Maeda. “Regional metabolic changes in the pedunculopontine nucleus of unilateral 6-hydroxydopamine Parkinson's model rats.” Brain Research 828, no. 1–2 (May 1999): 12–19. https://doi.org/10.1016/s0006-8993(99)01268-8.
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    • Sarraf-Yazdi, S., H. Sheng, H. P. Grocott, R. D. Bart, R. D. Pearlstein, R. P. Steffen, and D. S. Warner. “Effects of RSR13, a synthetic allosteric modifier of hemoglobin, alone and in combination with dizocilpine, on outcome from transient focal cerebral ischemia in the rat.” Brain Research 826, no. 2 (May 1999): 172–80. https://doi.org/10.1016/s0006-8993(99)01233-0.
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    • Sheng, H., D. T. Laskowitz, G. B. Mackensen, M. Kudo, R. D. Pearlstein, and D. S. Warner. “Apolipoprotein E deficiency worsens outcome from global cerebral ischemia in the mouse.” Stroke 30, no. 5 (May 1999): 1118–24. https://doi.org/10.1161/01.str.30.5.1118.
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    • Sheng, H., T. C. Brady, R. D. Pearlstein, J. D. Crapo, and D. S. Warner. “Extracellular superoxide dismutase deficiency worsens outcome from focal cerebral ischemia in the mouse.” Neuroscience Letters 267, no. 1 (May 1999): 13–16. https://doi.org/10.1016/s0304-3940(99)00316-x.
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    • Miura, Y., G. B. Mackensen, B. Nellgård, R. D. Pearlstein, R. D. Bart, F. Dexter, and D. S. Warner. “Effects of isoflurane, ketamine, and fentanyl/N2O on concentrations of brain and plasma catecholamines during near-complete cerebral ischemia in the rat.” Anesth Analg 88, no. 4 (April 1999): 787–92. https://doi.org/10.1097/00000539-199904000-00020.
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    • Sheng, H., D. T. Laskowitz, R. D. Pearlstein, and D. S. Warner. “Characterization of a recovery global cerebral ischemia model in the mouse.” Journal of Neuroscience Methods 88, no. 1 (April 1999): 103–9. https://doi.org/10.1016/s0165-0270(99)00018-7.
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    • Mackensen, G. B., B. Nellgård, Y. Miura, C. T. Chu, F. Dexter, R. D. Pearlstein, and D. S. Warner. “Sympathetic ganglionic blockade masks beneficial effect of isoflurane on histologic outcome from near-complete forebrain ischemia in the rat.” Anesthesiology 90, no. 3 (March 1999): 873–81. https://doi.org/10.1097/00000542-199903000-00031.
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    • Grocott, H. P., H. Sheng, Y. Miura, S. Sarraf-Yazdi, G. B. Mackensen, R. D. Pearlstein, and D. S. Warner. “The effects of aprotinin on outcome from cerebral ischemia in the rat.” Anesth Analg 88, no. 1 (January 1999): 1–7. https://doi.org/10.1097/00000539-199901000-00001.
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    • Sarraf-Yazdi, S., H. Sheng, A. D. Brinkhous, R. D. Pearlstein, and D. S. Warner. “Effects of postischemic halothane administration on outcome from transient focal cerebral ischemia in the rat.” J Neurosurg Anesthesiol 11, no. 1 (January 1999): 31–36. https://doi.org/10.1097/00008506-199901000-00006.
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    • Sheng, H., R. D. Bart, T. D. Oury, R. D. Pearlstein, J. D. Crapo, and D. S. Warner. “Mice overexpressing extracellular superoxide dismutase have increased resistance to focal cerebral ischemia.” Neuroscience 88, no. 1 (January 1999): 185–91. https://doi.org/10.1016/s0306-4522(98)00208-5.
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    • Bart, R., H. Sheng, T. Oury, J. Crapo, R. Pearlstein, and D. Warner. “Modulation of cerebral blood flow is not the mechanism of neuroprotection in transgenic mice over expressing human extracellular superoxide dismutase (EC-SOD).” Critical Care Medicine 26, no. 1 SUPPL. (December 1, 1998).
    • Bart, R. D., H. Sheng, D. T. Laskowitz, R. D. Pearlstein, and D. S. Warner. “Regional CBF in apolipoprotein E-deficient and wild type mice during focal cerebral ischemia.” Neuroreport 9, no. 11 (August 3, 1998): 2615–20. https://doi.org/10.1097/00001756-199808030-00035.
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    • Grocott, H. P., R. D. Bart, H. Sheng, Y. Miura, R. Steffen, R. D. Pearlstein, and D. S. Warner. “Effects of a synthetic allosteric modifier of hemoglobin oxygen affinity on outcome from global cerebral ischemia in the rat.” Stroke 29, no. 8 (August 1998): 1650–55. https://doi.org/10.1161/01.str.29.8.1650.
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    • Miura, Y., H. P. Grocott, R. D. Bart, R. D. Pearlstein, F. Dexter, and D. S. Warner. “Differential effects of anesthetic agents on outcome from near-complete but not incomplete global ischemia in the rat.” Anesthesiology 89, no. 2 (August 1998): 391–400. https://doi.org/10.1097/00000542-199808000-00016.
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    • Sarraf-Yazdi, S., H. Sheng, Y. Miura, C. McFarlane, F. Dexter, R. Pearlstein, and D. S. Warner. “Relative neuroprotective effects of dizocilpine and isoflurane during focal cerebral ischemia in the rat.” Anesth Analg 87, no. 1 (July 1998): 72–78. https://doi.org/10.1097/00000539-199807000-00016.
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    • Bart, R. D., S. Takaoka, R. D. Pearlstein, F. Dexter, and D. S. Warner. “Interactions between hypothermia and the latency to ischemic depolarization: implications for neuroprotection.” Anesthesiology 88, no. 5 (May 1998): 1266–73. https://doi.org/10.1097/00000542-199805000-00018.
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    • Pearlstein, R. D., J. P. Beirne, G. W. Massey, and D. S. Warner. “Neuroprotective effects of NMDA receptor glycine recognition site antagonism: dependence on glycine concentration.” Journal of Neurochemistry 70, no. 5 (May 1998): 2012–19. https://doi.org/10.1046/j.1471-4159.1998.70052012.x.
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    • Sheng, H., D. T. Laskowitz, E. Bennett, D. E. Schmechel, R. D. Bart, A. M. Saunders, R. D. Pearlstein, A. D. Roses, and D. S. Warner. “Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice.” J Cereb Blood Flow Metab 18, no. 4 (April 1998): 361–66. https://doi.org/10.1097/00004647-199804000-00003.
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    • Beirne, J. P., R. D. Pearlstein, G. W. Massey, and D. S. Warner. “Effect of halothane in cortical cell cultures exposed to N-methyl-D-aspartate.” Neurochem Res 23, no. 1 (January 1998): 17–23. https://doi.org/10.1023/a:1022489017731.
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    • Morimoto, Y., B. Wu, R. D. Bart, R. D. Pearlstein, and D. S. Warner. “Effects of NMDA receptor glycine recognition site antagonism on cerebral metabolic rate for glucose and cerebral blood flow in the conscious rat.” Brain Res 779, no. 1–2 (January 1, 1998): 170–76. https://doi.org/10.1016/s0006-8993(97)01113-x.
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    • Pittman, J. E., H. Sheng, R. Pearlstein, A. Brinkhous, F. Dexter, and D. S. Warner. “Comparison of the effects of propofol and pentobarbital on neurologic outcome and cerebral infarct size after temporary focal ischemia in the rat.” Anesthesiology 87, no. 5 (November 1997): 1139–44. https://doi.org/10.1097/00000542-199711000-00018.
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    • Morimoto, Y., R. D. Bart, R. D. Pearlstein, F. Dexter, and D. S. Warner. “High-dose fentanyl does not adversely affect outcome from forebrain ischemia in the rat.” J Neurosurg Anesthesiol 9, no. 4 (October 1997): 316–23. https://doi.org/10.1097/00008506-199710000-00005.
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    • Takaoka, S., R. D. Bart, R. D. Pearlstein, and D. S. Warner. “Glycine antagonism does not block ischemic spontaneous depolarization in the rat.” Neuroreport 8, no. 5 (March 24, 1997): 1139–42. https://doi.org/10.1097/00001756-199703240-00016.
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    • Takaoka, S., R. D. Bart, R. Pearlstein, A. Brinkhous, and D. S. Warner. “Neuroprotective effect of NMDA receptor glycine recognition site antagonism persists when brain temperature is controlled.” J Cereb Blood Flow Metab 17, no. 2 (February 1997): 161–67. https://doi.org/10.1097/00004647-199702000-00005.
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    • Iacono, R. P., S. M. Kuniyoshi, J. R. Ahlman, G. J. Zimmerman, G. Maeda, and R. D. Pearlstein. “Concentrations of indoleamine metabolic intermediates in the ventricular cerebrospinal fluid of advanced Parkinson's patients with severe postural instability and gait disorders.” J Neural Transm (Vienna) 104, no. 4–5 (1997): 451–59. https://doi.org/10.1007/BF01277663.
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    • Takaoka, S., R. D. Pearlstein, and D. S. Warner. “Hypothermia reduces the propensity of cortical tissue to propagate direct current depolarizations in the rat.” Neurosci Lett 218, no. 1 (October 25, 1996): 25–28. https://doi.org/10.1016/0304-3940(96)13112-8.
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    • Morimoto, Y., D. S. Warner, and R. D. Pearlstein. “Acute changes in intracranial pressure and pressure-volume index after forebrain ischemia in normoglycemic and hyperglycemic rats.” Stroke 27, no. 8 (August 1996): 1405–9. https://doi.org/10.1161/01.str.27.8.1405.
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    • Warner, D. S., S. Takaoka, B. Wu, P. S. Ludwig, R. D. Pearlstein, A. D. Brinkhous, and F. Dexter. “Electroencephalographic burst suppression is not required to elicit maximal neuroprotection from pentobarbital in a rat model of focal cerebral ischemia.” Anesthesiology 84, no. 6 (June 1996): 1475–84. https://doi.org/10.1097/00000542-199606000-00024.
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    • Warner, D. S., P. S. Ludwig, R. Pearlstein, and A. D. Brinkhous. “Halothane reduces focal ischemic injury in the rat when brain temperature is controlled.” Anesthesiology 82, no. 5 (May 1995): 1237–45. https://doi.org/10.1097/00000542-199505000-00019.
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    • Warner, D. S., P. S. Ludwig, R. Pearlstein, A. D. Brinkhous, and M. M. Todd. “Halothane reduces focal ischemic injury in the rat when brain temperature is controlled.” Anesthesiology 82, no. 5 (January 1, 1995).
    • Kramer, R. S., and R. D. Pearlstein. “Reversible uncoupling of oxidative phosphorylation at low oxygen tension.” Proc Natl Acad Sci U S A 80, no. 19 (October 1983): 5807–11. https://doi.org/10.1073/pnas.80.19.5807.
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    • Iacono, R. P., R. D. Pearlstein, and B. S. Nashold. “Neurogenic control of cerebral blood flow in the pathoetiology of cerebral vasospasm.” Surgical Forum VOL. 34 (January 1, 1983): 510–12.
    • Higgins, A. C., R. D. Pearlstein, J. B. Mullen, and B. S. Nashold. “Effects of hyperbaric oxygen therapy on long-tract neuronal conduction in the acute phase of spinal cord injury.” J Neurosurg 55, no. 4 (October 1981): 501–10. https://doi.org/10.3171/jns.1981.55.4.0501.
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    • Kramer, R. S., and R. D. Pearlstein. “Cerebral cortical microfluorometry at isosbestic wavelengths for correction of vascular artifact.” Science 205, no. 4407 (August 17, 1979): 693–96. https://doi.org/10.1126/science.223243.
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