Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of North Carolina at Chapel Hill 1983
  • M.S., University of North Carolina at Chapel Hill 1981
• 

  Duke Appointment History

  • Assistant Research Professor in Surgery, Neurosurgery, Neurosurgery 1998 - 2006
• Expertise
• 

  Global Scholarship

  • Research

    • Afghanistan (Country) 
• Research
• 

  Selected Grants

  • Xenon As A Therapeutic in Experimental Intracerebral Hemorrhage  awarded by National Institutes of Health 2015 - 2018
  • Radiation Medicine Central Nervous System Studies Phase II  awarded by Loma Linda University 2016
  • Radiation Medicine Central Nervous System Studies Phase II  awarded by Loma Linda University 2015 - 2016
  • Technology Support for Combat Related Medical Infrared Imaging in Afghanistan  awarded by Air Force Office of Scientific Research 2010 - 2012
  • Technology Support for Combat Related Medical Infrared Imaging in Iraq  awarded by Air Force Office of Scientific Research 2007 - 2008
  • Biomedical and Biological Research Applications of a Storage-Ring Free-Electron Laser  awarded by Air Force Office of Scientific Research 2000 - 2008
  • Anesthetics, GABA and the Injured Brain  awarded by National Institutes of Health 2003 - 2008
  • Extracellular Oxygen Radicals and Ischemic Brain Injury  awarded by National Institutes of Health 2000 - 2003
• Publications & Artistic Works
• 

  Selected Publications

  • Journal Articles

    • Chaparro, RE, Izutsu, M, Sasaki, T, Sheng, H, Zheng, Y, Sadeghian, H, Qin, T, von Bornstadt, D, Herisson, F, Duan, B, Li, J-S, Jiang, K, Pearlstein, M, Pearlstein, RD, Smith, DE, Goldberg, ID, Ayata, C, and Warner, DS. "Sustained functional improvement by hepatocyte growth factor-like small molecule BB3 after focal cerebral ischemia in rats and mice." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 35, no. 6 (June 2015): 1044-1053.  Full Text
    • Sheng, H, Chaparro, RE, Sasaki, T, Izutsu, M, Pearlstein, RD, Tovmasyan, A, and Warner, DS. "Metalloporphyrins as therapeutic catalytic oxidoreductants in central nervous system disorders." Antioxid Redox Signal 20, no. 15 (May 20, 2014): 2437-2464. (Review)  Full Text  Link to Item
    • Archambeau, JO, Tovmasyan, A, Pearlstein, RD, Crapo, JD, and Batinic-Haberle, I. "Superoxide dismutase mimic, MnTE-2-PyP(5+) ameliorates acute and chronic proctitis following focal proton irradiation of the rat rectum. (Published online)" Redox Biol 1 (2013): 599-607.  Full Text  Link to Item
    • Yang, W, Wang, L, Roehn, G, Pearlstein, RD, Ali-Osman, F, Pan, H, Goldbrunner, R, Krantz, M, Harms, C, and Paschen, W. "Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival." Cancer Sci 104, no. 1 (January 2013): 70-77.  Full Text  Link to Item
    • Yang, W, Wang, L, Roehn, G, Pearlstein, RD, Ali-Osman, F, Pan, H, Goldbrunner, R, Krantz, M, Harms, C, and Paschen, W. "Small ubiquitin-like modifier 1-3 is activated in human astrocytic brain tumors and is required for glioblastoma cell survival." Cancer Science 104, no. 1 (2013): 70-77.  Full Text
    • Sheng, SP, Lei, B, James, ML, Lascola, CD, Venkatraman, TN, Jung, JY, Maze, M, Franks, NP, Pearlstein, RD, Sheng, H, and Warner, DS. "Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage." Anesthesiology 117, no. 6 (December 2012): 1262-1275.  Full Text  Link to Item
    • Makinde, AY, Rizvi, A, Crapo, JD, Pearlstein, RD, Slater, JM, and Gridley, DS. "A metalloporphyrin antioxidant alters cytokine responses after irradiation in a prostate tumor model." Radiat Res 173, no. 4 (April 2010): 441-452.  Full Text  Link to Item
    • Pearlstein, RD, Higuchi, Y, Moldovan, M, Johnson, K, Fukuda, S, Gridley, DS, Crapo, JD, Warner, DS, and Slater, JM. "Metalloporphyrin antioxidants ameliorate normal tissue radiation damage in rat brain." Int J Radiat Biol 86, no. 2 (February 2010): 145-163.  Full Text  Link to Item
    • Finch, AS, Moldovan, M, Frank, J, Bagnell, R, Katz, LM, and Pearlstein, RD. "Transient mild hypothermia differentially alters mitotic activity in normal and post-ischemic hippocampal slices from neonatal rats." Journal of Thermal Biology 35, no. 4 (2010): 189-196.  Full Text
    • Sheng, H, Yang, W, Fukuda, S, Tse, HM, Paschen, W, Johnson, K, Batinic-Haberle, I, Crapo, JD, Pearlstein, RD, Piganelli, J, and Warner, DS. "Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat." Free Radic Biol Med 47, no. 7 (October 1, 2009): 917-923.  Full Text  Link to Item
    • Makinde, AY, Luo-Owen, X, Rizvi, A, Crapo, JD, Pearlstein, RD, Slater, JM, and Gridley, DS. "Effect of a metalloporphyrin antioxidant (MnTE-2-PyP) on the response of a mouse prostate cancer model to radiation." Anticancer Res 29, no. 1 (January 2009): 107-118.  Link to Item
    • Wagner, W, Sokolow, A, Pearlstein, R, and Edwards, G. "Thermal vapor bubble and pressure dynamics during infrared laser ablation of tissue." Applied Physics Letters 94, no. 1 (2009).  Full Text
    • Kittle, D, Holshouser, B, Slater, JM, Guenther, BD, Pitsianis, NP, and Pearlstein, RD. "Technical note: rapid prototyping of 3D grid arrays for image guided therapy quality assurance." Med Phys 35, no. 12 (December 2008): 5708-5712.  Full Text  Link to Item
    • Katz, LM, Nauriyal, V, Nagaraj, S, Finch, A, Pearlstein, K, Szymanowski, A, Sproule, C, Rich, PB, Guenther, BD, and Pearlstein, RD. "Infrared imaging of trauma patients for detection of acute compartment syndrome of the leg." Crit Care Med 36, no. 6 (June 2008): 1756-1761.  Full Text  Link to Item
    • Edwards, G, Wagner, W, Sokolow, A, and Pearlstein, R. "Pressure (mechanical) effects in infrared tissue ablation." Progress in Biomedical Optics and Imaging - Proceedings of SPIE 6854 (2008).  Full Text
    • Edwards, GS, Pearlstein, RD, Copeland, ML, Hutson, MS, Latone, K, Spiro, A, and Pasmanik, G. "6450 nm wavelength tissue ablation using a nanosecond laser based on difference frequency mixing and stimulated Raman scattering." Opt Lett 32, no. 11 (June 1, 2007): 1426-1428.  Link to Item
    • Gridley, DS, Makinde, AY, Luo, X, Rizvi, A, Crapo, JD, Dewhirst, MW, Moeller, BJ, Pearlstein, RD, and Slater, JM. "Radiation and a metalloporphyrin radioprotectant in a mouse prostate tumor model." Anticancer Research 27, no. 5 A (2007): 3101-3109.
    • Sakai, H, Sheng, H, Yates, RB, Ishida, K, Pearlstein, RD, and Warner, DS. "Isoflurane provides long-term protection against focal cerebral ischemia in the rat." Anesthesiology 106, no. 1 (January 2007): 92-99.  Link to Item
    • Wise-Faberowski, L, Pearlstein, RD, and Warner, DS. "NMDA-induced apoptosis in mixed neuronal/glial cortical cell cultures: the effects of isoflurane and dizocilpine." J Neurosurg Anesthesiol 18, no. 4 (October 2006): 240-246.  Link to Item
    • Elsersy, H, Mixco, J, Sheng, H, Pearlstein, RD, and Warner, DS. "Selective gamma-aminobutyric acid type A receptor antagonism reverses isoflurane ischemic neuroprotection." Anesthesiology 105, no. 1 (July 2006): 81-90.  Link to Item
    • Pearlstein, RD, Whitten, C, and Haerich, P. "Assessing neurocognitive dysfunction in cranial radiotherapy: can cognitive event-related potentials help?." Technol Cancer Res Treat 5, no. 2 (April 2006): 109-125. (Review)  Full Text  Link to Item
    • Leinenweber, SB, Sheng, H, Lynch, JR, Wang, H, Batinić-Haberle, I, Laskowitz, DT, Crapo, JD, Pearlstein, RD, and Warner, DS. "Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model." Eur J Pharmacol 531, no. 1-3 (February 15, 2006): 126-132.  Full Text  Link to Item
    • Sakai, H, Yates, R, Sheng, H, Pearlstein, R, and Warner, DS. "Isoflurane provides sustained neuroprotection in rats subjected to focal ischemia." Journal of Neurosurgical Anesthesiology 18, no. 4 (January 1, 2006): 281-.
    • Wise-Faberowski, L, Zhang, H, Ing, R, Pearlstein, RD, and Warner, DS. "Isoflurane-induced neuronal degeneration: an evaluation in organotypic hippocampal slice cultures." Anesth Analg 101, no. 3 (September 2005): 651-657.  Full Text  Link to Item
    • McAdoo, JD, Warner, DS, Goldberg, RN, Vitek, MP, Pearlstein, R, and Laskowitz, DT. "Intrathecal administration of a novel apoE-derived therapeutic peptide improves outcome following perinatal hypoxic-ischemic injury." Neurosci Lett 381, no. 3 (June 24, 2005): 305-308.  Full Text  Link to Item
    • Wise-Faberowski, L, Aono, M, Pearlstein, RD, and Warner, DS. "Apoptosis is not enhanced in primary mixed neuronal/glial cultures protected by isoflurane against N-methyl-D-aspartate excitotoxicity." Anesth Analg 99, no. 6 (December 2004): 1708-1714.  Full Text  Link to Item
    • Homi, HM, Yang, H, Pearlstein, RD, and Grocott, HP. "Hemodilution during cardiopulmonary bypass increases cerebral infarct volume after middle cerebral artery occlusion in rats." Anesth Analg 99, no. 4 (October 2004): 974-981.  Full Text  Link to Item
    • Yokoo, N, Sheng, H, Mixco, J, Homi, HM, Pearlstein, RD, and Warner, DS. "Intraischemic nitrous oxide alters neither neurologic nor histologic outcome: a comparison with dizocilpine." Anesth Analg 99, no. 3 (September 2004): 896-903.  Full Text  Link to Item
    • Elsersy, H, Sheng, H, Lynch, JR, Moldovan, M, Pearlstein, RD, and Warner, DS. "Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat." Anesthesiology 100, no. 5 (May 2004): 1160-1166.  Link to Item
    • Sheng, H, Wang, H, Homi, HM, Spasojevic, I, Batinic-Haberle, I, Pearlstein, RD, and Warner, DS. "A no-laminectomy spinal cord compression injury model in mice." J Neurotrauma 21, no. 5 (May 2004): 595-603.  Full Text  Link to Item
    • Lee, Y, Aono, M, Laskowitz, D, Warner, DS, and Pearlstein, RD. "Apolipoprotein E protects against oxidative stress in mixed neuronal-glial cell cultures by reducing glutamate toxicity." Neurochem Int 44, no. 2 (January 2004): 107-118.  Link to Item
    • Rich, PB, Dulabon, GR, Douillet, CD, Listwa, TM, Robinson, WP, Zarzaur, BL, Pearlstein, R, and Katz, LM. "Infrared thermography: A rapid, portable, and accurate technique to detect experimental pneumothorax." Journal of Surgical Research 120, no. 2 (2004): 163-170.  Full Text
    • Homi, HM, Mixco, JM, Sheng, H, Grocott, HP, Pearlstein, RD, and Warner, DS. "Severe hypotension is not essential for isoflurane neuroprotection against forebrain ischemia in mice." Anesthesiology 99, no. 5 (November 2003): 1145-1151.  Link to Item
    • Aono, M, Bennett, ER, Kim, KS, Lynch, JR, Myers, J, Pearlstein, RD, Warner, DS, and Laskowitz, DT. "Protective effect of apolipoprotein E-mimetic peptides on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cell cultures." Neuroscience 116, no. 2 (2003): 437-445.  Link to Item
    • Ovelmen-Levitt, J, Straub, KD, Hauger, S, Szarmes, E, Madey, J, Pearlstein, RD, and Nashold, BS. "Brain ablation in the rat cerebral cortex using a tunable-free electron laser." Lasers Surg Med 33, no. 2 (2003): 81-92.  Full Text  Link to Item
    • Higuchi, Y, Nelson, GA, Vazquez, M, Laskowitz, DT, Slater, JM, and Pearlstein, RD. "Apolipoprotein E expression and behavioral toxicity of high charge, high energy (HZE) particle radiation." J Radiat Res 43 Suppl (December 2002): S219-S224.  Link to Item
    • McGirt, MJ, Lynch, JR, Parra, A, Sheng, H, Pearlstein, RD, Laskowitz, DT, Pelligrino, DA, and Warner, DS. "Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage." Stroke 33, no. 12 (December 2002): 2950-2956.  Link to Item
    • Bowler, RP, Sheng, H, Enghild, JJ, Pearlstein, RD, Warner, DS, and Crapo, JD. "A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke." Free Radic Biol Med 33, no. 8 (October 15, 2002): 1141-1152.  Link to Item
    • Aono, M, Lee, Y, Grant, ER, Zivin, RA, Pearlstein, RD, Warner, DS, Bennett, ER, and Laskowitz, DT. "Apolipoprotein E protects against NMDA excitotoxicity." Neurobiol Dis 11, no. 1 (October 2002): 214-220.  Link to Item
    • Sheng, H, Enghild, JJ, Bowler, R, Patel, M, Batinić-Haberle, I, Calvi, CL, Day, BJ, Pearlstein, RD, Crapo, JD, and Warner, DS. "Effects of metalloporphyrin catalytic antioxidants in experimental brain ischemia." Free Radic Biol Med 33, no. 7 (October 1, 2002): 947-961.  Link to Item
    • McGirt, MJ, Parra, A, Sheng, H, Higuchi, Y, Oury, TD, Laskowitz, DT, Pearlstein, RD, and Warner, DS. "Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpressing extracellular superoxide dismutase." Stroke 33, no. 9 (September 2002): 2317-2323.  Link to Item
    • Lockhart, EM, Warner, DS, Pearlstein, RD, Penning, DH, Mehrabani, S, and Boustany, R-M. "Allopregnanolone attenuates N-methyl-D-aspartate-induced excitotoxicity and apoptosis in the human NT2 cell line in culture." Neurosci Lett 328, no. 1 (August 2, 2002): 33-36.  Link to Item
    • Parra, A, McGirt, MJ, Sheng, H, Laskowitz, DT, Pearlstein, RD, and Warner, DS. "Mouse model of subarachnoid hemorrhage associated cerebral vasospasm: methodological analysis." Neurol Res 24, no. 5 (July 2002): 510-516.  Full Text  Link to Item
    • Wainwright, MS, Sheng, H, Sato, Y, Mackensen, GB, Steffen, RP, Pearlstein, RD, and Warner, DS. "Pharmacological correction of hypothermic P(50) shift does not alter outcome from focal cerebral ischemia in rats." Am J Physiol Heart Circ Physiol 282, no. 5 (May 2002): H1863-H1870.  Full Text  Link to Item
    • Higuchi, Y, Nashold, BS, Sluijter, M, Cosman, E, and Pearlstein, RD. "Exposure of the dorsal root ganglion in rats to pulsed radiofrequency currents activates dorsal horn lamina I and II neurons." Neurosurgery 50, no. 4 (April 2002): 850-855.  Link to Item
    • Wainwright, MS, Sheng, H, Sato, Y, Mackensen, GB, Steffen, RP, Pearlstein, RD, and Warner, DS. "Pharmacological correction of hypothermic P₅₀ shift does not alter outcome from focal cerebral ischemia in rats." American Journal of Physiology - Heart and Circulatory Physiology 282, no. 5 51-5 (2002): H1863-H1870.
    • Kudo, M, Aono, M, Lee, Y, Massey, G, Pearlstein, RD, and Warner, DS. "Effects of volatile anesthetics on N-methyl-D-aspartate excitotoxicity in primary rat neuronal-glial cultures." Anesthesiology 95, no. 3 (September 2001): 756-765.  Link to Item
    • Mackensen, GB, Patel, M, Sheng, H, Calvi, CL, Batinic-Haberle, I, Day, BJ, Liang, LP, Fridovich, I, Crapo, JD, Pearlstein, RD, and Warner, DS. "Neuroprotection from delayed postischemic administration of a metalloporphyrin catalytic antioxidant." J Neurosci 21, no. 13 (July 1, 2001): 4582-4592.  Link to Item
    • Pineda, JA, Aono, M, Sheng, H, Lynch, J, Wellons, JC, Laskowitz, DT, Pearlstein, RD, Bowler, R, Crapo, J, and Warner, DS. "Extracellular superoxide dismutase overexpression improves behavioral outcome from closed head injury in the mouse." J Neurotrauma 18, no. 6 (June 2001): 625-634.  Full Text  Link to Item
    • Kudo, M, Aono, M, Lee, Y, Massey, G, Pearlstein, RD, and Warner, DS. "Absence of direct antioxidant effects from volatile anesthetics in primary mixed neuronal-glial cultures." Anesthesiology 94, no. 2 (February 2001): 303-212.  Link to Item
    • Mackensen, GB, Nellgârd, B, Kudo, M, Sheng, H, Pearlstein, RD, and Warner, DS. "Periischemic cerebral blood flow (CBF) does not explain beneficial effects of isoflurane on outcome from near-complete forebrain ischemia in rats." Anesthesiology 93, no. 4 (October 2000): 1102-1106.  Link to Item
    • Nellgård, B, Mackensen, GB, Pineda, J, Wellons, JC, Pearlstein, RD, and Warner, DS. "Anesthetic effects on cerebral metabolic rate predict histologic outcome from near-complete forebrain ischemia in the rat." Anesthesiology 93, no. 2 (August 2000): 431-436.  Link to Item
    • Nellgård, B, Mackensen, GB, Massey, G, Pearlstein, RD, and Warner, DS. "The effects of anesthetics on stress responses to forebrain ischemia and reperfusion in the rat." Anesth Analg 91, no. 1 (July 2000): 145-151.  Link to Item
    • Wellons, JC, Sheng, H, Laskowitz, DT, Mackensen, GB, Pearlstein, RD, and Warner, DS. "A comparison of strain-related susceptibility in two murine recovery models of global cerebral ischemia." Brain Res 868, no. 1 (June 16, 2000): 14-21.  Link to Item
    • Sheng, H, Kudo, M, Mackensen, GB, Pearlstein, RD, Crapo, JD, and Warner, DS. "Mice overexpressing extracellular superoxide dismutase have increased resistance to global cerebral ischemia." Exp Neurol 163, no. 2 (June 2000): 392-398.  Full Text  Link to Item
    • Nellgård, BM, Miura, Y, Mackensen, GB, Pearlstein, RD, and Warner, DS. "Effect of intracerebral norepinephrine depletion on outcome from severe forebrain ischemia in the rat." Brain Res 847, no. 2 (November 20, 1999): 262-269.  Link to Item
    • Nellgård, B, Mackensen, GB, Sarraf-Yazdi, S, Miura, Y, Pearlstein, R, and Warner, DS. "Pre-ischemic depletion of brain norepinephrine decreases infarct size in normothermic rats exposed to transient focal cerebral ischemia." Neurosci Lett 275, no. 3 (November 19, 1999): 167-170.  Link to Item
    • Sheng, H, Brady, TC, Pearlstein, RD, Crapo, JD, and Warner, DS. "Extracellular superoxide dismutase deficiency worsens outcome from focal cerebral ischemia in the mouse." Neurosci Lett 267, no. 1 (May 21, 1999): 13-16.  Link to Item
    • Carlson, JD, Pearlstein, RD, Buchholz, J, Iacono, RP, and Maeda, G. "Regional metabolic changes in the pedunculopontine nucleus of unilateral 6-hydroxydopamine Parkinson's model rats." Brain Res 828, no. 1-2 (May 15, 1999): 12-19.  Link to Item
    • Sarraf-Yazdi, S, Sheng, H, Grocott, HP, Bart, RD, Pearlstein, RD, Steffen, RP, and Warner, DS. "Effects of RSR13, a synthetic allosteric modifier of hemoglobin, alone and in combination with dizocilpine, on outcome from transient focal cerebral ischemia in the rat." Brain Res 826, no. 2 (May 1, 1999): 172-180.  Link to Item
    • Sheng, H, Laskowitz, DT, Mackensen, GB, Kudo, M, Pearlstein, RD, and Warner, DS. "Apolipoprotein E deficiency worsens outcome from global cerebral ischemia in the mouse." Stroke 30, no. 5 (May 1999): 1118-1124.  Link to Item
    • Miura, Y, Mackensen, GB, Nellgård, B, Pearlstein, RD, Bart, RD, Dexter, F, and Warner, DS. "Effects of isoflurane, ketamine, and fentanyl/N2O on concentrations of brain and plasma catecholamines during near-complete cerebral ischemia in the rat." Anesth Analg 88, no. 4 (April 1999): 787-792.  Link to Item
    • Sheng, H, Laskowitz, DT, Pearlstein, RD, and Warner, DS. "Characterization of a recovery global cerebral ischemia model in the mouse." J Neurosci Methods 88, no. 1 (April 1, 1999): 103-109.  Link to Item
    • Mackensen, GB, Nellgård, B, Miura, Y, Chu, CT, Dexter, F, Pearlstein, RD, and Warner, DS. "Sympathetic ganglionic blockade masks beneficial effect of isoflurane on histologic outcome from near-complete forebrain ischemia in the rat." Anesthesiology 90, no. 3 (March 1999): 873-881.  Link to Item
    • Grocott, HP, Sheng, H, Miura, Y, Sarraf-Yazdi, S, Mackensen, GB, Pearlstein, RD, and Warner, DS. "The effects of aprotinin on outcome from cerebral ischemia in the rat." Anesth Analg 88, no. 1 (January 1999): 1-7.  Link to Item
    • Pineda, JA, Cheifetz, IM, Katz, LM, Grenn, M, and Pearlstein, RD. "Critical care applications of infrared imaging." Critical Care Medicine 27, no. 12 SUPPL. (1999): A89-.
    • Sarraf-Yazdi, S, Sheng, H, Brinkhous, AD, Pearlstein, RD, and Warner, DS. "Effects of postischemic halothane administration on outcome from transient focal cerebral ischemia in the rat." J Neurosurg Anesthesiol 11, no. 1 (January 1999): 31-36.  Link to Item
    • Sheng, H, Bart, RD, Oury, TD, Pearlstein, RD, Crapo, JD, and Warner, DS. "Mice overexpressing extracellular superoxide dismutase have increased resistance to focal cerebral ischemia." Neuroscience 88, no. 1 (January 1999): 185-191.  Link to Item
    • Bart, RD, Sheng, H, Laskowitz, DT, Pearlstein, RD, and Warner, DS. "Regional CBF in apolipoprotein E-deficient and wild type mice during focal cerebral ischemia." Neuroreport 9, no. 11 (August 3, 1998): 2615-2620.  Link to Item
    • Grocott, HP, Bart, RD, Sheng, H, Miura, Y, Steffen, R, Pearlstein, RD, and Warner, DS. "Effects of a synthetic allosteric modifier of hemoglobin oxygen affinity on outcome from global cerebral ischemia in the rat." Stroke 29, no. 8 (August 1998): 1650-1655.  Link to Item
    • Miura, Y, Grocott, HP, Bart, RD, Pearlstein, RD, Dexter, F, and Warner, DS. "Differential effects of anesthetic agents on outcome from near-complete but not incomplete global ischemia in the rat." Anesthesiology 89, no. 2 (August 1998): 391-400.  Link to Item
    • Sarraf-Yazdi, S, Sheng, H, Miura, Y, McFarlane, C, Dexter, F, Pearlstein, R, and Warner, DS. "Relative neuroprotective effects of dizocilpine and isoflurane during focal cerebral ischemia in the rat." Anesth Analg 87, no. 1 (July 1998): 72-78.  Link to Item
    • Bart, RD, Takaoka, S, Pearlstein, RD, Dexter, F, and Warner, DS. "Interactions between hypothermia and the latency to ischemic depolarization: implications for neuroprotection." Anesthesiology 88, no. 5 (May 1998): 1266-1273.  Link to Item
    • Pearlstein, RD, Beirne, JP, Massey, GW, and Warner, DS. "Neuroprotective effects of NMDA receptor glycine recognition site antagonism: dependence on glycine concentration." J Neurochem 70, no. 5 (May 1998): 2012-2019.  Link to Item
    • Sheng, H, Laskowitz, DT, Bennett, E, Schmechel, DE, Bart, RD, Saunders, AM, Pearlstein, RD, Roses, AD, and Warner, DS. "Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice." J Cereb Blood Flow Metab 18, no. 4 (April 1998): 361-366.  Full Text  Link to Item
    • Bart, R, Sheng, H, Oury, T, Crapo, J, Pearlstein, R, and Warner, D. "Modulation of cerebral blood flow is not the mechanism of neuroprotection in transgenic mice over expressing human extracellular superoxide dismutase (EC-SOD)." Critical Care Medicine 26, no. 1 SUPPL. (1998): A36-.
    • Beirne, JP, Pearlstein, RD, Massey, GW, and Warner, DS. "Effect of halothane in cortical cell cultures exposed to N-methyl-D-aspartate." Neurochem Res 23, no. 1 (January 1998): 17-23.  Link to Item
    • Morimoto, Y, Wu, B, Bart, RD, Morimoto, Y, Pearlstein, RD, and Warner, DS. "Effects of NMDA receptor glycine recognition site antagonism on cerebral metabolic rate for glucose and cerebral blood flow in the conscious rat." Brain Res 779, no. 1-2 (January 1, 1998): 170-176.  Link to Item
    • Pittman, JE, Sheng, H, Pearlstein, R, Brinkhous, A, Dexter, F, and Warner, DS. "Comparison of the effects of propofol and pentobarbital on neurologic outcome and cerebral infarct size after temporary focal ischemia in the rat." Anesthesiology 87, no. 5 (November 1997): 1139-1144.  Link to Item
    • Morimoto, Y, Morimoto, Y, Bart, RD, Pearlstein, RD, Dexter, F, and Warner, DS. "High-dose fentanyl does not adversely affect outcome from forebrain ischemia in the rat." J Neurosurg Anesthesiol 9, no. 4 (October 1997): 316-323.  Link to Item
    • Takaoka, S, Bart, RD, Pearlstein, RD, and Warner, DS. "Glycine antagonism does not block ischemic spontaneous depolarization in the rat." Neuroreport 8, no. 5 (March 24, 1997): 1139-1142.  Link to Item
    • Takaoka, S, Bart, RD, Pearlstein, R, Brinkhous, A, and Warner, DS. "Neuroprotective effect of NMDA receptor glycine recognition site antagonism persists when brain temperature is controlled." J Cereb Blood Flow Metab 17, no. 2 (February 1997): 161-167.  Full Text  Link to Item
    • Iacono, RP, Kuniyoshi, SM, Ahlman, JR, Zimmerman, GJ, Maeda, G, and Pearlstein, RD. "Concentrations of indoleamine metabolic intermediates in the ventricular cerebrospinal fluid of advanced Parkinson's patients with severe postural instability and gait disorders." J Neural Transm (Vienna) 104, no. 4-5 (1997): 451-459.  Full Text  Link to Item
    • Takaoka, S, Pearlstein, RD, and Warner, DS. "Hypothermia reduces the propensity of cortical tissue to propagate direct current depolarizations in the rat." Neurosci Lett 218, no. 1 (October 25, 1996): 25-28.  Link to Item
    • Morimoto, Y, Morimoto, Y, Warner, DS, and Pearlstein, RD. "Acute changes in intracranial pressure and pressure-volume index after forebrain ischemia in normoglycemic and hyperglycemic rats." Stroke 27, no. 8 (August 1996): 1405-1409.  Link to Item
    • Warner, DS, Takaoka, S, Wu, B, Ludwig, PS, Pearlstein, RD, Brinkhous, AD, and Dexter, F. "Electroencephalographic burst suppression is not required to elicit maximal neuroprotection from pentobarbital in a rat model of focal cerebral ischemia." Anesthesiology 84, no. 6 (June 1996): 1475-1484.  Link to Item
    • Warner, DS, Ludwig, PS, Pearlstein, R, and Brinkhous, AD. "Halothane reduces focal ischemic injury in the rat when brain temperature is controlled." Anesthesiology 82, no. 5 (May 1995): 1237-1245.  Link to Item
    • Warner, DS, Ludwig, PS, Pearlstein, R, Brinkhous, AD, and Todd, MM. "Halothane reduces focal ischemic injury in the rat when brain temperature is controlled." Anesthesiology 82, no. 5 (1995): 27A-30A.
    • Kramer, RS, and Pearlstein, RD. "Reversible uncoupling of oxidative phosphorylation at low oxygen tension." Proc Natl Acad Sci U S A 80, no. 19 (October 1983): 5807-5811.  Link to Item
    • Iacono, RP, Pearlstein, RD, and Jr, BSN. "Neurogenic control of cerebral blood flow in the pathoetiology of cerebral vasospasm." Surgical Forum VOL. 34 (1983): 510-512.
    • Kramer, RS, and Pearlstein, RD. "Reversible uncoupling of oxidative phosphorylation at low oxygen tension." Proceedings of the National Academy of Sciences of the United States of America 80, no. 19 I (1983): 5807-5811.
    • Higgins, AC, Pearlstein, RD, Mullen, JB, and Nashold, BS. "Effects of hyperbaric oxygen therapy on long-tract neuronal conduction in the acute phase of spinal cord injury." J Neurosurg 55, no. 4 (October 1981): 501-510.  Full Text  Link to Item
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